|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
1-356 |
1.17e-92 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 282.21 E-value: 1.17e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 1 MRRRERMNKVKILKVIGAIIALFSFLTIIWSIAFYVASSILDALEINVSPFVTFLISDMVGFVFIVLIWVLIGVLMRPKR 80
Cdd:COG5002 33 LLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 81 EAMIWTIIEPIQKIAKGDFSVKIRNEEKYDGEIGVLVKSINDMTdELNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQ 160
Cdd:COG5002 113 LLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDIT-ELERLEQMRREFVANVSHELRTPLTSIRGYLELLL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 161 DDNL-SEEKRKHYLTIIETETTRLSKLSQNLLKLTLLESEEYTPEKVNYRLDQQLKQIVLNSEPLWDEKEIELDLDL--E 237
Cdd:COG5002 192 DGAAdDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLpeD 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 238 KVHITADQESMSQVWINLIYNSIKFTPSGGTITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFYKADSSRNRAYGGS 317
Cdd:COG5002 272 PLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGT 351
|
330 340 350
....*....|....*....|....*....|....*....
gi 657628659 318 GLGLAIVKKVLDLHRGEIKVESEEGNGTEFTVCIPKYKE 356
Cdd:COG5002 352 GLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
120-356 |
6.00e-80 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 244.43 E-value: 6.00e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 120 INDMTDELNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQDD-NLSEEKRKHYLTIIETETTRLSKLSQNLLKLTLLES 198
Cdd:COG2205 2 LEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEeDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLES 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 199 EEYTPEKVNYRLDQQLKQIVLNSEPLWDEKEIELDLDL--EKVHITADQESMSQVWINLIYNSIKFTPSGGTITIQLNEY 276
Cdd:COG2205 82 GKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLppELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARRE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 277 EKAVEVCIRDSGIGISEEQKQHIFERFYKADSSRNraYGGSGLGLAIVKKVLDLHRGEIKVESEEGNGTEFTVCIPKYKE 356
Cdd:COG2205 162 GDGVRISVSDNGPGIPEEELERIFERFYRGDNSRG--EGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAES 239
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
25-353 |
9.60e-73 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 229.02 E-value: 9.60e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 25 FLTIIWSIAFYVASSILDALEINVSPFVTFLISDMVGFVFIVLIWVLIGVLMRPKREAMIWTIIEPIQKIAKGDFSVKIR 104
Cdd:COG0642 1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 105 NEEKYDGEIGVLVKSINDMTDELNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQDDnlSEEKRKHYLTIIETETTRLS 184
Cdd:COG0642 81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEE--LDEEQREYLETILRSADRLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 185 KLSQNLLKLTLLESEEYTPEKVNYRLDQQLKQIVLNSEPLWDEKEIELDLDLEK--VHITADQESMSQVWINLIYNSIKF 262
Cdd:COG0642 159 RLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDdlPTVRGDPDRLRQVLLNLLSNAIKY 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 263 TPSGGTITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFYKADSSRNraYGGSGLGLAIVKKVLDLHRGEIKVESEEG 342
Cdd:COG0642 239 TPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRR--GGGTGLGLAIVKRIVELHGGTIEVESEPG 316
|
330
....*....|.
gi 657628659 343 NGTEFTVCIPK 353
Cdd:COG0642 317 KGTTFTVTLPL 327
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
110-357 |
1.75e-48 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 166.95 E-value: 1.75e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 110 DGEIGVLVkSINDMTD------ELNAMEKMR--QEFVSNVSHEIQSPLTSIKGFARALQDDnLSEEKRKHYLTIIETETT 181
Cdd:COG3852 104 EGEGGVLL-VLRDITErkrlerELRRAEKLAavGELAAGLAHEIRNPLTGIRGAAQLLERE-LPDDELREYTQLIIEEAD 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 182 RLSKLSQNLLKLTLLESEEYTPEKVNYRLDQqLKQIVLNSEPlwDEKEIELDLDLEKVHITADQESMSQVWINLIYNSIK 261
Cdd:COG3852 182 RLNNLVDRLLSFSRPRPPEREPVNLHEVLER-VLELLRAEAP--KNIRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAE 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 262 FTPSGGTITIQL----------NEYEKAVEVCIRDSGIGISEEQKQHIFERFYkadSSRNrayGGSGLGLAIVKKVLDLH 331
Cdd:COG3852 259 AMPEGGTITIRTrverqvtlggLRPRLYVRIEVIDNGPGIPEEILDRIFEPFF---TTKE---KGTGLGLAIVQKIVEQH 332
|
250 260
....*....|....*....|....*.
gi 657628659 332 RGEIKVESEEGNGTEFTVCIPKYKEK 357
Cdd:COG3852 333 GGTIEVESEPGKGTTFRIYLPLEQAE 358
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
65-352 |
3.25e-48 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 169.04 E-value: 3.25e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 65 IVLIWVLIGVLMRP-KReamiwtIIEPIQKIAKGDFSVKIRNEEKydGEIGVLVKSINDMTDELNAMEKMRQEFVSNVSH 143
Cdd:PRK10549 178 ALATFLLARGLLAPvKR------LVEGTHKLAAGDFTTRVTPTSR--DELGRLAQDFNQLASTLEKNEQMRRDFMADISH 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 144 EIQSPLTSIKGFARALQDDnlseeKRK---HYLTIIETETTRLSKLSQNLLKLTLleSEE----YTPEKVNyrLDQQLKQ 216
Cdd:PRK10549 250 ELRTPLAVLRGELEAIQDG-----VRKftpESVASLQAEVGTLTKLVDDLHQLSL--SDEgalaYRKTPVD--LVPLLEV 320
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 217 IVLNSEPLWDEKEIELDLDL-EKVHITADQESMSQVWINLIYNSIKFTPSGGTITIQLNEYEKAVEVCIRDSGIGISEEQ 295
Cdd:PRK10549 321 AGGAFRERFASRGLTLQLSLpDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQ 400
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 657628659 296 KQHIFERFYKADSSRNRAYGGSGLGLAIVKKVLDLHRGEIKVESEEGNGTEFTVCIP 352
Cdd:PRK10549 401 LQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELP 457
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
1-356 |
1.34e-47 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 168.04 E-value: 1.34e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 1 MRRRERMNKVKILKVIGAIIALFSFLTIIWSIAFYVASSILDALEINVSPFVTFLISDMVGFVFIVLIWVLIGVLMRPKR 80
Cdd:COG4251 149 LLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLL 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 81 EAMIWTIIEPIQKIAKGDFSVKIRNEEKYDGEIGVLVKSINDMTDELNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQ 160
Cdd:COG4251 229 LLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERSNEELEQFAYVASHDLREPLRKISGFSQLLE 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 161 DD---NLSEEKRkHYLTIIETETTRLSKLSQNLLKLTLLESEEYTPEKVNyrLDQQLKQIVLNSEPLWDEKEIELDLDlE 237
Cdd:COG4251 309 EDygdKLDEEGR-EYLERIRDAAERMQALIDDLLAYSRVGRQELEFEPVD--LNELLEEVLEDLEPRIEERGAEIEVG-P 384
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 238 KVHITADQESMSQVWINLIYNSIKFTPSG--GTITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFYKADSSRNraYG 315
Cdd:COG4251 385 LPTVRGDPTLLRQVFQNLISNAIKYSRPGepPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDE--YE 462
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 657628659 316 GSGLGLAIVKKVLDLHRGEIKVESEEGNGTEFTVCIPKYKE 356
Cdd:COG4251 463 GTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKAPA 503
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
112-353 |
4.47e-47 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 164.75 E-value: 4.47e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 112 EIGVLVkSINDMTDELNAmEKMR--QEFVSNVSHEIQSPLTSIKGFARALQD---DNLSE--EKRKHYLTIIETETTRLS 184
Cdd:COG5000 179 DDGYVI-VFDDITELLRA-ERLAawGELARRIAHEIKNPLTPIQLSAERLRRklaDKLEEdrEDLERALDTIIRQVDRLK 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 185 KLSQNLLKLTLLEseeyTPEKVNYRLDQQLKQIVLNSEPLWDEKEIELDLDLEK--VHITADQESMSQVWINLIYNSIKF 262
Cdd:COG5000 257 RIVDEFLDFARLP----EPQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPdlPEVLADRDQLEQVLINLLKNAIEA 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 263 TPSGGTITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFYkadSSRNRaygGSGLGLAIVKKVLDLHRGEIKVESEEG 342
Cdd:COG5000 333 IEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF---TTKPK---GTGLGLAIVKKIVEEHGGTIELESRPG 406
|
250
....*....|.
gi 657628659 343 NGTEFTVCIPK 353
Cdd:COG5000 407 GGTTFTIRLPL 417
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
35-353 |
1.01e-44 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 159.62 E-value: 1.01e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 35 YVASSILDALEI-----------NVSPFV-----TFLisdMVGFVFIVLIwVLIGVLMrpkreamIWTIIEPIQKIAkgD 98
Cdd:PRK11100 149 YVAAPIRDGGRIigvlsvgkpnsSMAPFIkrserRIL---WAGALLLGIA-LLIGAGV-------VWWLNRSIRRLT--R 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 99 FSVKIRNEEKYD------GEIGVLVKsindmtdelnAMEKMRQE---------FVSNVSHEIQSPLTSIKGFARALQDDn 163
Cdd:PRK11100 216 YADAVTEGKPVPlpklgsSELRELAQ----------ALESMRVKlegkayveqYVQTLTHELKSPLAAIRGAAELLQED- 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 164 LSEEKRKHYLTIIETETTRLSKLSQNLLKLTLLES--EEYTPEKVNyrLDQQLKQIVLNSEPLWDEKEIELDLDLEKVHI 241
Cdd:PRK11100 285 PPPEDRARFTGNILTQSARLQQLIDRLLELARLEQrqELEVLEPVA--LAALLEELVEAREAQAAAKGITLRLRPDDARV 362
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 242 TADQESMSQVWINLIYNSIKFTPSGGTITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFY---KADSSRNraygGSG 318
Cdd:PRK11100 363 LGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYslpRPANGRK----STG 438
|
330 340 350
....*....|....*....|....*....|....*
gi 657628659 319 LGLAIVKKVLDLHRGEIKVESEEGNGTEFTVCIPK 353
Cdd:PRK11100 439 LGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPR 473
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
2-352 |
1.77e-41 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 148.79 E-value: 1.77e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 2 RRRERMNKVKILKVIGAIIALFSFLTIIWSIAFYVASSILDALEINVSPFVTFLISDMVGFVFIVLIWVLIGVLMRPKRE 81
Cdd:COG4191 1 ALRLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 82 AMIWTIIEPIQKIAKGDFSVKIRNEEKYDGEIGVLVKSINDMTDELNAME-KMRQ--------EFVSNVSHEIQSPLTSI 152
Cdd:COG4191 81 LLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQeQLVQseklaalgELAAGIAHEINNPLAAI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 153 KGFARALQ---DDNLSEEKRKHYLTIIETETTRLSKLSQNLLklTLLESEEYTPEKVNyrLDQQLKQIVLNSEPLWDEKE 229
Cdd:COG4191 161 LGNAELLRrrlEDEPDPEELREALERILEGAERAAEIVRSLR--AFSRRDEEEREPVD--LNELIDEALELLRPRLKARG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 230 IELDLDLEK--VHITADQESMSQVWINLIYNSIKFTPSG--GTITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFY- 304
Cdd:COG4191 237 IEVELDLPPdlPPVLGDPGQLEQVLLNLLINAIDAMEEGegGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFt 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 657628659 305 -KADSsrnrayGGSGLGLAIVKKVLDLHRGEIKVESEEGNGTEFTVCIP 352
Cdd:COG4191 317 tKPVG------KGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
108-357 |
2.11e-41 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 151.28 E-value: 2.11e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 108 KYDGEIGVLVKSINDMTDELNAMEKMRQ--------EFVSNVSHEIQSPLTSIKGFARALQDDNLSEEKRkhYLTIIETE 179
Cdd:COG5809 236 KKNGEVDGIVIIFRDITERKKLEELLRKseklsvvgELAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQKT--YLDIMLSE 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 180 TTRLSKLSQNLLKLTLLESEEYtpEKVNyrLDQQLKQIV--LNSEPLWDEKEIELDLDLEKVHITADQESMSQVWINLIY 257
Cdd:COG5809 314 LDRIESIISEFLVLAKPQAIKY--EPKD--LNTLIEEVIplLQPQALLKNVQIELELEDDIPDILGDENQLKQVFINLLK 389
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 258 NSIKFTPSGGTITIQLN-EYEKAVEVCIRDSGIGISEEQKQHIFERFYkadssrNRAYGGSGLGLAIVKKVLDLHRGEIK 336
Cdd:COG5809 390 NAIEAMPEGGNITIETKaEDDDKVVISVTDEGCGIPEERLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKIT 463
|
250 260
....*....|....*....|.
gi 657628659 337 VESEEGNGTEFTVCIPKYKEK 357
Cdd:COG5809 464 VESEVGKGTTFSITLPIKLSE 484
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
248-352 |
8.07e-41 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 139.17 E-value: 8.07e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 248 MSQVWINLIYNSIKFTPSGG-TITIQLNEYEK---AVEVCIRDSGIGISEEQKQHIFERFYKADSSRNRAYGGSGLGLAI 323
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEvTLRVSLEEEEEdgvQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 657628659 324 VKKVLDLHRGEIKVESEEGNGTEFTVCIP 352
Cdd:cd16922 81 SKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
97-354 |
2.86e-40 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 145.31 E-value: 2.86e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 97 GDFSVKIRNEEKYDGEIGVLVKSINDMTDELNAMEKMRQ--------EFVSNVSHEIQSPLTSIKGFARALQDDNlSEEK 168
Cdd:COG5807 102 GEFDEIIYPIYYKDGVILGLITVYRDITKRKEAEDKLLRseklsvagELAAGIAHEIRNPLTSIKGFLQLLQESR-EDSE 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 169 RKHYLTIIETETTRLSKLSQNLLKLTLLESEEYTPEKVNyrldQQLKQIVLNSEPLWDEKEIELDLDL--EKVHITADQE 246
Cdd:COG5807 181 REEYFNIIISEIDRINTIITELLVLSKPKKFNFKKLNLN----DVLEDVIALLSTEAILKNISIKYDLadDEPVINGDKN 256
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 247 SMSQVWINLIYNSIKFTPSGGTITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFYKADSSrnraygGSGLGLAIVKK 326
Cdd:COG5807 257 QLKQVFINLIKNAIEAMETGGNITIKTYVEGDFVVISVKDEGIGIPEEVLEKIGEPFFTTKEE------GTGLGLSICKK 330
|
250 260
....*....|....*....|....*...
gi 657628659 327 VLDLHRGEIKVESEEGNGTEFTVCIPKY 354
Cdd:COG5807 331 IIEEHNGTIEVESKPGKGTTFTIYLPLY 358
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
131-356 |
1.07e-39 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 146.05 E-value: 1.07e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 131 EKMRQEFVSNVSHEIQSPLTSIKGFARALQDDNLSEEKRKhYLTIIETETTRLSKLSQNLLKLTLLESEEYTPEKVNYRL 210
Cdd:COG5808 238 LELIGTFAASTAHEIRNPLTSIKGFIQLLQEKYPELEDQK-YFDIIQEEIQRINQIVSEFLVLGKPTAKKLELDDLNELI 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 211 DQQLKqiVLNSEPLWDEKEIELDLDLEKVHITADQESMSQVWINLIYNSIKFTPSGGTITIQLNEYEKAVEVCIRDSGIG 290
Cdd:COG5808 317 EEILS--IIDSEANLKNIRVEKQSLDEPLHIKCDKDRIKQVLLNLIKNAIEAMKEGGKLTISIENDDEKAVIEVIDNGEG 394
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 657628659 291 ISEEQKQHIFERFYKADSsrnrayGGSGLGLAIVKKVLDLHRGEIKVESEEGNGTEFTVCIPKYKE 356
Cdd:COG5808 395 IPEDIIDEIFEPFVTTKE------GGTGLGLSVCKRIVEMHGGEIDIESEEGKGTTFTIRLPLKKE 454
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
243-353 |
3.73e-39 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 134.70 E-value: 3.73e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 243 ADQESMSQVWINLIYNSIKFTPSGGTITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFYKADsSRNRAYGGSGLGLA 322
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTD-KRSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|.
gi 657628659 323 IVKKVLDLHRGEIKVESEEGNGTEFTVCIPK 353
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITLPL 110
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
63-352 |
8.04e-39 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 143.68 E-value: 8.04e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 63 VFIVLIWVLIGVL-----MRPKREamiwtIIEPIQKIAKGDFSVKIrNEEKYDGEIGVLVKSINDMTDELNAMEKMRQEF 137
Cdd:TIGR01386 171 VLLVLLTALLGWWitrlgLEPLRR-----LSAVAARISPESLDQRL-DPSRAPAELRELAQSFNAMLGRLEDAFQRLSQF 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 138 VSNVSHEIQSPLTSIKGFARALqddnLSEEKR-KHYLTIIET---ETTRLSKLSQNLLKLTLLESEEYTPEKVNYRLDQQ 213
Cdd:TIGR01386 245 SADLAHELRTPLTNLLGQTQVA----LSQPRTgEEYREVLESnleELERLSRMVSDMLFLARADNGQLALERVRLDLAAE 320
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 214 LKQIVLNSEPLWDEKEIELDLDLEKVhITADQESMSQVWINLIYNSIKFTPSGGTITIQLNEYEKAVEVCIRDSGIGISE 293
Cdd:TIGR01386 321 LAKVAEYFEPLAEERGVRIRVEGEGL-VRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIPP 399
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 657628659 294 EQKQHIFERFYKADSSRNRAYGGSGLGLAIVKKVLDLHRGEIKVESEEGNgTEFTVCIP 352
Cdd:TIGR01386 400 EHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGK-TRFILRFP 457
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
122-353 |
8.19e-39 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 142.84 E-value: 8.19e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 122 DMTdELNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQDDNLSEEKRKHYLTIIETETTRLSKLSQNLLKLTLLESeey 201
Cdd:PRK11006 193 DVT-QMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPLEGALREKALHTMREQTQRMEGLVKQLLTLSKIEA--- 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 202 TPE-KVNYRLDQQLKQIVLNSEP--LWDEK-EIELDLDlEKVHITADQESMSQVWINLIYNSIKFTPSGGTITIQLNEYE 277
Cdd:PRK11006 269 APTiDLNEKVDVPMMLRVLEREAqtLSQGKhTITFEVD-NSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVP 347
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 657628659 278 KAVEVCIRDSGIGISEEQKQHIFERFYKADSSRNRAYGGSGLGLAIVKKVLDLHRGEIKVESEEGNGTEFTVCIPK 353
Cdd:PRK11006 348 QGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLPE 423
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
113-357 |
2.14e-37 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 141.64 E-value: 2.14e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 113 IGVLVkSINDMTDELNAMEKMRQ--------EFVSNVSHEIQSPLTSIKGFARALQDDNLSEEKRkHYLTIIETETTRLS 184
Cdd:PRK11360 362 IGALV-IFSDLTERKRLQRRVARqerlaalgELVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPSQ-EYLSVVLREVDRLN 439
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 185 KLSQNLLKLTLLESEEYTPEKVNyRLDQQLKQIVLNSEpLWDEKEIELDLDLEKVHITADQESMSQVWINLIYNSIKFTP 264
Cdd:PRK11360 440 KVIDQLLEFSRPRESQWQPVSLN-ALVEEVLQLFQTAG-VQARVDFETELDNELPPIWADPELLKQVLLNILINAVQAIS 517
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 265 SGGTITIQL-NEYEKAVEVCIRDSGIGISEEQKQHIFERFYKADSSrnraygGSGLGLAIVKKVLDLHRGEIKVESEEGN 343
Cdd:PRK11360 518 ARGKIRIRTwQYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTTKAK------GTGLGLALSQRIINAHGGDIEVESEPGV 591
|
250
....*....|....
gi 657628659 344 GTEFTVCIPKYKEK 357
Cdd:PRK11360 592 GTTFTLYLPINPQG 605
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
99-353 |
4.77e-36 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 136.79 E-value: 4.77e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 99 FSVKIRNEEKYDGEIGVLVKSINDMTDELNAMEKMRQ--------EFVSNVSHEIQSPLTSIKGFARALQddnLSEEKRK 170
Cdd:COG5805 244 FEAVIVPLIDTDGSVKGILVILRDITEKKEAEELMARseklsiagQLAAGIAHEIRNPLTSIKGFLQLLQ---PGIEDKE 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 171 HYLTIIETETTRLSKLSQNLLKLTLLESEEYTPEKVNyrldQQLKQIV--LNSEPLWDEKEIELDLDLEKVHITADQESM 248
Cdd:COG5805 321 EYFDIMLSELDRIESIISEFLALAKPQAVNKEKENIN----ELIQDVVtlLETEAILHNIQIRLELLDEDPFIYCDENQI 396
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 249 SQVWINLIYNSIKFTPSGGTITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFYKADSSrnraygGSGLGLAIVKKVL 328
Cdd:COG5805 397 KQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKEK------GTGLGLMVSYKII 470
|
250 260
....*....|....*....|....*
gi 657628659 329 DLHRGEIKVESEEGNGTEFTVCIPK 353
Cdd:COG5805 471 ENHNGTIDIDSKVGKGTTFTITLPL 495
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
248-349 |
7.39e-36 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 125.79 E-value: 7.39e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 248 MSQVWINLIYNSIKFTPSGGTITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFYKADSSRNRayGGSGLGLAIVKKV 327
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREG--GGTGLGLAIVRRI 78
|
90 100
....*....|....*....|..
gi 657628659 328 LDLHRGEIKVESEEGNGTEFTV 349
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTV 100
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
26-353 |
2.25e-35 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 134.51 E-value: 2.25e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 26 LTIIWSIAFYVasSILDALE---INVSPFVTFLIsdmvgfVFIVLIWVLIGvlMRPKREamiwtIIEPIQKIAKGDFSVK 102
Cdd:PRK09835 167 LLIALSIDFHL--HYINDLKnklIMTASVISLLI------VFIVLLAVHKG--HAPIRS-----VSRQIQNITSKDLDVR 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 103 IrNEEKYDGEIGVLVKSINDMTDELNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQDDNLSEEKRKHYLTIIETETTR 182
Cdd:PRK09835 232 L-DPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLYSNLEELTR 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 183 LSKLSQNLLKLTLLESEEYTPEKVNYRLDQQLKQIVLNSEPLWDEKEIELDLDLEKVHITADQESMSQVWINLIYNSIKF 262
Cdd:PRK09835 311 MAKMVSDMLFLAQADNNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVELRFVGDPCQVAGDPLMLRRAISNLLSNALRY 390
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 263 TPSGGTITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFYKADSSRNRAYGGSGLGLAIVKKVLDLHRGEIKVESeEG 342
Cdd:PRK09835 391 TPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTS-DA 469
|
330
....*....|.
gi 657628659 343 NGTEFTVCIPK 353
Cdd:PRK09835 470 RGTRFVISLPR 480
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
117-354 |
4.59e-34 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 129.60 E-value: 4.59e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 117 VKSINDMTDELNAMEKMR--QEFVSNVSHEIQSPLTSIKGFARALQDDNLSEEKRKHYLTIIETETTRLSKLSQNLLKLT 194
Cdd:COG5806 182 LIENILLRKELQRAEKLEvvSELAASIAHEVRNPLTVVRGFIQLLQEPELSDEKRKQYIRIALEELDRAEAIITDYLTFA 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 195 LLESEEYtpEKVNyrLDQQLKQIVLNSEPLWDEKEIELDLDLE-KVHITADQESMSQVWINLIYNSIKFTPSGGTITIQL 273
Cdd:COG5806 262 KPQPEKL--EKID--VSEELEHVIDVLSPYANMNNVEIQTELEpGLYIEGDRQKLQQCLINIIKNGIEAMPNGGTLTIDV 337
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 274 NEYEKAVEVCIRDSGIGISEEQKQHIFERFY--KADssrnraygGSGLGLAIVKKVLDLHRGEIKVESEEGNGTEFTVCI 351
Cdd:COG5806 338 SIDKNKVIISIKDTGVGMTKEQLERLGEPYFstKEK--------GTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITL 409
|
...
gi 657628659 352 PKY 354
Cdd:COG5806 410 PLA 412
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
118-352 |
6.77e-33 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 127.21 E-value: 6.77e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 118 KSINDMTDELNAMEKMRQ--EFVSNVSHEIQSPLTSIKGFARALQDDNLSEEKRKHYLTIIETETTRLSKLSQNLLKLTL 195
Cdd:PRK10364 219 RSRQLLQDEMKRKEKLVAlgHLAAGVAHEIRNPLSSIKGLAKYFAERAPAGGEAHQLAQVMAKEADRLNRVVSELLELVK 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 196 LESEEYTPEKVNYRLDQQLKQIVLNSEplwdEKEIELDL----DLEKvhITADQESMSQVWINLIYNSIKFTPSGGTITI 271
Cdd:PRK10364 299 PTHLALQAVDLNDLINHSLQLVSQDAN----SREIQLRFtandTLPE--IQADPDRLTQVLLNLYLNAIQAIGQHGVISV 372
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 272 QLNEYEKAVEVCIRDSGIGISEEQKQHIFERFY--KADssrnraygGSGLGLAIVKKVLDLHRGEIKVESEEGNGTEFTV 349
Cdd:PRK10364 373 TASESGAGVKISVTDSGKGIAADQLEAIFTPYFttKAE--------GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTL 444
|
...
gi 657628659 350 CIP 352
Cdd:PRK10364 445 WLP 447
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
243-352 |
1.77e-31 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 114.77 E-value: 1.77e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 243 ADQESMSQVWINLIYNSIKFTPSGGTITIQLNEyEKAVEVCIRDSGIGISEEQKQHIFERFYKADSsrnRAYGGSGLGLA 322
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSE-GGELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLS 76
|
90 100 110
....*....|....*....|....*....|
gi 657628659 323 IVKKVLDLHRGEIKVESEEGNGTEFTVCIP 352
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPGGGTTVTLTLP 106
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
112-354 |
1.06e-30 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 120.06 E-value: 1.06e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 112 EIGVLVKSINDMTDELNAMEKMrqefVSNVSHEIQSPLT--SIkgfarALQ---------DDNLSEEKRKHYLTIIETET 180
Cdd:PRK09303 133 ELFVLRQENETLLEQLKFKDRV----LAMLAHDLRTPLTaaSL-----ALEtlelgqideDTELKPALIEQLQDQARRQL 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 181 TRLSKLSQNLLKL--TLLESEEYTPEKVNyrLDQQLKQIVLNSEPLWDEKEIELDLD----LEKVHitADQESMSQVWIN 254
Cdd:PRK09303 204 EEIERLITDLLEVgrTRWEALRFNPQKLD--LGSLCQEVILELEKRWLAKSLEIQTDipsdLPSVY--ADQERIRQVLLN 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 255 LIYNSIKFTPSGGTITIQ-LNEYEKAVEVCIRDSGIGISEEQKQHIFERFYKAdsSRNRAYGGSGLGLAIVKKVLDLHRG 333
Cdd:PRK09303 280 LLDNAIKYTPEGGTITLSmLHRTTQKVQVSICDTGPGIPEEEQERIFEDRVRL--PRDEGTEGYGIGLSVCRRIVRVHYG 357
|
250 260
....*....|....*....|.
gi 657628659 334 EIKVESEEGNGTEFTVCIPKY 354
Cdd:PRK09303 358 QIWVDSEPGQGSCFHFTLPVY 378
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
64-352 |
1.26e-30 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 120.86 E-value: 1.26e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 64 FIVLIWvligvlMRPKREAMIwTIIEPIQKIAKGDFSVKIRNEEKydGEIGVLVKSINDMTDELNAMEKMRQEFVSNVSH 143
Cdd:PRK10604 151 FPVFLW------MRPHWQDML-KLEAAAQRLGDGHLAERIHFDEG--SSLERLGVAFNQMADNINALIASKKQLIDGIAH 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 144 EIQSPLTSIKgfARALQDDNLSEEKRKhyltIIETETTRLSKLSQNLLKLTLLESEEYTPEKVNYRLDQQLKQIVLNSEP 223
Cdd:PRK10604 222 ELRTPLVRLR--YRLEMSDNLSAAESQ----ALNRDIGQLEALIEELLTYARLDRPQNELHLSEPDLPAWLSTHLADIQA 295
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 224 LWDEKEIELDLDLEKVHITADQESMSQVWINLIYNSIKFTPSGGTITIQLNEYEKAVEVciRDSGIGISEEQKQHIFERF 303
Cdd:PRK10604 296 VTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYAHSRVRVSLLLDGNQACLIV--EDDGPGIPPEERERVFEPF 373
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 657628659 304 YKADSSRNRAYGGSGLGLAIVKKVLDLHRGEIKVESEEGNGTEFTVCIP 352
Cdd:PRK10604 374 VRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWP 422
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
85-357 |
2.12e-30 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 120.42 E-value: 2.12e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 85 WTIIEPIQK-------IAKGDFsvKIRNE-EKYDGEIGVLVKSINDMTDELNAMEKMRQEFVSNVSHEIQSPLTSIKgFA 156
Cdd:PRK09470 188 WSLAKPARKlknaadeVAQGNL--RQHPElETGPQEFRQAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQ-LA 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 157 RALQddnlseeKRKH----YLTIIETETTRLSKLSQNLLKLTLLEseeytpekvnyrLDQQLKQIVLNSEPLWDE----- 227
Cdd:PRK09470 265 TALL-------RRRQgeskELERIETEAQRLDSMINDLLVLSRNQ------------QKNHLERETFKANSLWSEvleda 325
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 228 --------KEIELDLDLEKVHITADQESMSQVWINLIYNSIKFTPSggTITIQLNEYEKAVEVCIRDSGIGISEEQKQHI 299
Cdd:PRK09470 326 kfeaeqmgKSLTVSAPPGPWPINGNPNALASALENIVRNALRYSHT--KIEVAFSVDKDGLTITVDDDGPGVPEEEREQI 403
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 657628659 300 FERFYKADSSRNRAYGGSGLGLAIVKKVLDLHRGEIKVESEEGNGTEFTVCIPKYKEK 357
Cdd:PRK09470 404 FRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLPLYKRS 461
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
244-352 |
3.96e-30 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 111.02 E-value: 3.96e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 244 DQESMSQVWINLIYNSIKFTPSGGTITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFYKADSSRNRAYGGSGLGLAI 323
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 657628659 324 VKKVLDLHRGEIKVESEEGNGTEFTVCIP 352
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
254-352 |
2.61e-29 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 108.83 E-value: 2.61e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 254 NLIYNSIKFTPSGGTITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFYKADSSRNRAYGGSGLGLAIVKKVLDLHRG 333
Cdd:cd16952 7 NLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRHDA 86
|
90
....*....|....*....
gi 657628659 334 EIKVESEEGNGTEFTVCIP 352
Cdd:cd16952 87 RLLIASELGKGSRFTCLFP 105
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
43-350 |
3.58e-29 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 117.06 E-value: 3.58e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 43 ALEINVSPFVTFLISdmVGFVFIVLIWVLigvlmrpKREamiwtiIEPIQKIAKG------DFSVKIrNEEKYDGEIGVL 116
Cdd:PRK10337 156 ALAIVAGQLIPWLVA--LPIMLIILMVLL-------GRE------LAPLKKLALAlrmrdpDSETPL-NATGVPSEVRPL 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 117 VKSINDMTDELNAMEKMRQEFVSNVSHEIQSPLTSIK---GFARALQDDnlsEEKRKHYLTIIETETTRLSKLSQNLLKL 193
Cdd:PRK10337 220 VEALNQLFARTHAMMVRERRFTSDAAHELRSPLAALKvqtEVAQLSDDD---PQARKKALLQLHAGIDRATRLVDQLLTL 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 194 TLLESEEYTPEKVNYRLDQQLKQIVLNSEPLWDEKEIELDLDLEKVHITADQESM--SQVWINLIYNSIKFTPSGGTITI 271
Cdd:PRK10337 297 SRLDSLDNLQDVAEIPLEDLLQSAVMDIYHTAQQAGIDVRLTLNAHPVIRTGQPLllSLLVRNLLDNAIRYSPQGSVVDV 376
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 272 QLNEYEKAVevciRDSGIGISEEQKQHIFERFYkadssrnRAYG----GSGLGLAIVKKVLDLHRGEIKVESEEGNGTEF 347
Cdd:PRK10337 377 TLNARNFTV----RDNGPGVTPEALARIGERFY-------RPPGqeatGSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEA 445
|
...
gi 657628659 348 TVC 350
Cdd:PRK10337 446 KVS 448
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
63-352 |
6.25e-29 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 118.03 E-value: 6.25e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 63 VFIVLIWVLIGVLMrpkreAMIWT------IIEPIQ-------KIAKGDFSVKIrnEEKYDGEIGVLVKSINDMTDELNA 129
Cdd:PRK11107 177 IFIAFLMLLLGIGL-----ALLFAfrlmrdVTGPIRnmvntvdRIRRGQLDSRV--EGNMLGELDMLKNGINAMAMSLSA 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 130 M-EKMRQ--------------------------------------EFVSNVSHEIQSPLTSIKGFARALQDDNLSEEKRK 170
Cdd:PRK11107 250 YhEEMQQnidqatsdlretleqmeiqnveldlakkraqeaariksEFLANMSHELRTPLNGVIGFTRQTLKTPLTPTQRD 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 171 hYLTIIETETTRLSKLSQNLLKLTLLESEEYTPEKVNYRLDQQLKQIVLNSEPLWDEKEIELDLDLE-KV--HITADQES 247
Cdd:PRK11107 330 -YLQTIERSANNLLAIINDILDFSKLEAGKLVLENIPFSLRETLDEVVTLLAHSAHEKGLELTLNIDpDVpdNVIGDPLR 408
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 248 MSQVWINLIYNSIKFTPSGG---TITIQLNEYEKA-VEVCIRDSGIGISEEQKQHIFERFYKADSSRNRAYGGSGLGLAI 323
Cdd:PRK11107 409 LQQIITNLVGNAIKFTESGNidiLVELRALSNTKVqLEVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVI 488
|
330 340
....*....|....*....|....*....
gi 657628659 324 VKKVLDLHRGEIKVESEEGNGTEFTVCIP 352
Cdd:PRK11107 489 TQKLVNEMGGDISFHSQPNRGSTFWFHLP 517
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
128-352 |
9.55e-28 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 114.27 E-value: 9.55e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 128 NAMEKMRQE---FVSNVSHEIQSPLTSIKGFARALQDDNLSEEKRKHYLTI---------IETETTRLSKLSQNLLKLTL 195
Cdd:PRK11091 274 DALEKASRDkttFISTISHELRTPLNGIVGLSRILLDTELTAEQRKYLKTIhvsaitlgnIFNDIIDMDKMERRKLQLDN 353
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 196 --LESEEYTPEKVNY-RLDQQLKQIVLNSEPLwdekeieldLDLEKvHITADQESMSQVWINLIYNSIKFTPSGG-TITI 271
Cdd:PRK11091 354 qpIDFTDFLADLENLsGLQAEQKGLRFDLEPL---------LPLPH-KVITDGTRLRQILWNLISNAVKFTQQGGvTVRV 423
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 272 QlneYEKAVEVC--IRDSGIGISEEQKQHIFERFYKA-DSSRNRAYGGSGLGLAIVKKVLDLHRGEIKVESEEGNGTEFT 348
Cdd:PRK11091 424 R---YEEGDMLTfeVEDSGIGIPEDELDKIFAMYYQVkDSHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFT 500
|
....
gi 657628659 349 VCIP 352
Cdd:PRK11091 501 LTIH 504
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
244-352 |
3.32e-27 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 103.34 E-value: 3.32e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 244 DQESMSQVWINLIYNSIKFTPSGGTITIQLNEYE-KAVEVCIRDSGIGISEEQKQHIFERFYKADSSRNRAYGGSGLGLA 322
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRlNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|
gi 657628659 323 IVKKVLDLHRGEIKVESEEGNGTEFTVCIP 352
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
131-352 |
5.78e-27 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 112.05 E-value: 5.78e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 131 EKMRQEFVSNVSHEIQSPLTSIKGFARALQDDnLSEEKRKHYLTI--IETETTRLSKLSQNLLKLTLLESEeytpeKVNY 208
Cdd:PRK10490 661 EQLRNALLAALSHDLRTPLTVLFGQAEILTLD-LASEGSPHARQAseIRQQVLNTTRLVNNLLDMARIQSG-----GFNL 734
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 209 RLD-QQLKQIV---LNS-EPLWDEKEIELDLDLEKVHITADQESMSQVWINLIYNSIKFTPSGGTITIQLNEYEKAVEVC 283
Cdd:PRK10490 735 RKEwLTLEEVVgsaLQMlEPGLSGHPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGERLQLD 814
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 657628659 284 IRDSGIGISEEQKQHIFERFYKADssRNRAYGGSGLGLAIVKKVLDLHRGEIKVESEEGNGTEFTVCIP 352
Cdd:PRK10490 815 VWDNGPGIPPGQEQLIFDKFARGN--KESAIPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLP 881
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
104-357 |
5.62e-25 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 106.21 E-value: 5.62e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 104 RNEekyDGEIGVLV---------KSINDMTdelNAMEKMRQE---FVSNVSHEIQSPLTSIKGFARALQDDNLSEEKRKh 171
Cdd:PRK10841 411 RNE---NVAICVLVdvsarvkmeESLQEMA---QAAEQASQSksmFLATVSHELRTPLYGIIGNLDLLQTKELPKGVDR- 483
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 172 YLTIIETETTRLSKLSQNLLKLTLLESE-------EYTPEKVnyrldqqLKQIVLNSEPLWDEKEIELDLDLEK---VHI 241
Cdd:PRK10841 484 LVTAMNNSSSLLLKIISDILDFSKIESEqlkieprEFSPREV-------INHITANYLPLVVKKRLGLYCFIEPdvpVAL 556
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 242 TADQESMSQVWINLIYNSIKFTPSGGtITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFYKADSSRNRAYGGSGLGL 321
Cdd:PRK10841 557 NGDPMRLQQVISNLLSNAIKFTDTGC-IVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGL 635
|
250 260 270
....*....|....*....|....*....|....*.
gi 657628659 322 AIVKKVLDLHRGEIKVESEEGNGTEFTVCIPKYKEK 357
Cdd:PRK10841 636 AICEKLINMMDGDISVDSEPGMGSQFTIRIPLYGAQ 671
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
236-349 |
6.90e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 97.48 E-value: 6.90e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 236 LEKVHITADQESMSQVWINLIYNSIKFTPSGGTITIQLNEYEKAVeVCIRDSGIGISEEQKQHIFERFYKADSsrnRAYG 315
Cdd:cd16940 2 AADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAV-IRVEDNGPGIDEEELEALFERFYRSDG---QNYG 77
|
90 100 110
....*....|....*....|....*....|....
gi 657628659 316 GSGLGLAIVKKVLDLHRGEIKVESEEGNGTEFTV 349
Cdd:cd16940 78 GSGLGLSIVKRIVELHGGQIFLGNAQGGGLEAWV 111
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
118-352 |
1.97e-24 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 104.82 E-value: 1.97e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 118 KSINDMTDELNAMEKMRQ----------EFVSNVSHEIQSPLTSIKGFARALQDDNLSEEKRKHYLTIIETETTRLSKLS 187
Cdd:PRK09959 686 QDITETRDLIHALEVERNkainatvaksQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLI 765
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 188 QNLLKLTLLESEEYTPEKVNYRLDQQLKQIVLNSEPLWDEKEIELDLDL---EKVHITADQESMSQVWINLIYNSIKFTP 264
Cdd:PRK09959 766 GEILDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCSStfpDHYLVKIDPQAFKQVLSNLLSNALKFTT 845
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 265 SGG----TITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFYKADSSRNRAygGSGLGLAIVKKVLDLHRGEIKVESE 340
Cdd:PRK09959 846 EGAvkitTSLGHIDDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNMQGDLSLESH 923
|
250
....*....|..
gi 657628659 341 EGNGTEFTVCIP 352
Cdd:PRK09959 924 PGIGTTFTITIP 935
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
229-349 |
6.51e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 95.27 E-value: 6.51e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 229 EIELDLDLEKVHITADQESMSQVWINLIYNSIKFTPSGGTITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFYKADS 308
Cdd:cd16947 2 QVEINIPDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLED 81
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 657628659 309 SRNRAYGGSGLGLAIVKKVLDLHRGEIKVESEEGNGTEFTV 349
Cdd:cd16947 82 SRNSAKQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTV 122
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
35-352 |
2.00e-23 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 101.64 E-value: 2.00e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 35 YVASSILDALEINVsPFVTFLISDMVGfvfiVLIWVLIGVLMRPkreamIWTIIEPIQKIAKGDFSVKIRnEEKYDgEIG 114
Cdd:PRK15347 286 NLANEALKPALQQL-PFALLILVLLTS----VLFLLLRRYLAKP-----LWRFVDIINKTGPAALEPRLP-ENRLD-ELG 353
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 115 VLVKSINDMTDELN---------------AMEKMRQ----------EFVSNVSHEIQSPLTSIKGFARALQDDNLSEEKR 169
Cdd:PRK15347 354 SIAKAYNQLLDTLNeqydtlenkvaertqALAEAKQraeqankrksEHLTTISHEIRTPLNGVLGALELLQNTPLTAEQM 433
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 170 K----------HYLTIIetettrlsklsQNLLKLTLLESEEYTpekVNYR-------LDQQLKQIVLN--SEPLWDE--- 227
Cdd:PRK15347 434 DladtarqctlSLLAII-----------NNLLDFSRIESGQMT---LSLEetallplLDQAMLTIQGPaqSKSLTLRtfv 499
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 228 -KEIELDLDLekvhitaDQESMSQVWINLIYNSIKFTPSGGtitIQLNEYEKAVEVCIR--DSGIGISEEQKQHIFERFY 304
Cdd:PRK15347 500 gAHVPLYLHL-------DSLRLRQILVNLLGNAVKFTETGG---IRLRVKRHEQQLCFTveDTGCGIDIQQQQQIFTPFY 569
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 657628659 305 KADSSRnrayGGSGLGLAIVKKVLDLHRGEIKVESEEGNGTEFTVCIP 352
Cdd:PRK15347 570 QADTHS----QGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLP 613
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
248-352 |
3.73e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 92.39 E-value: 3.73e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 248 MSQVWINLIYNSIKFTPSGGT--ITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFYKADSsrNRAYGGSGLGLAIVK 325
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPprIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHS--REEYEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 657628659 326 KVLDLHRGEIKVESEEGNGTEFTVCIP 352
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
254-353 |
2.31e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 90.08 E-value: 2.31e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 254 NLIYNSIKFTPSggTITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFYKADSSRNRAYGGSGLGLAIVKKVLDLHRG 333
Cdd:cd16949 7 NVLRNALRYSPS--KILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIEQHGG 84
|
90 100
....*....|....*....|
gi 657628659 334 EIKVESEEGNGTEFTVCIPK 353
Cdd:cd16949 85 KIKASNRKPGGLRVRIWLPA 104
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
246-352 |
6.94e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 86.32 E-value: 6.94e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 246 ESMSQVWINLIYNSIKFTPSGGTITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFYKadssrNRAYG-GSGLGLAIV 324
Cdd:cd16943 2 SQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFT-----TKPVGeGTGLGLSLS 76
|
90 100
....*....|....*....|....*...
gi 657628659 325 KKVLDLHRGEIKVESEEGNGTEFTVCIP 352
Cdd:cd16943 77 YRIIQKHGGTIRVASVPGGGTRFTIILP 104
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
45-352 |
8.14e-21 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 93.05 E-value: 8.14e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 45 EINVSPFVTFLISdmVGFVFIVLIWVLIGVLMRPKREamiwtiiepIQKIA----KGDFSVKIRneEKYDGEIGVLVKSI 120
Cdd:PRK09467 149 QGDFSPLFRYTLA--IGLLSVAGGWLFIRIQNRPLVA---------LEHAAlqvgKGEIPPPLR--EYGASEVRSVTRAF 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 121 NDMTDELNAMEKMRQEFVSNVSHEIQSPLTSIKgfaraLQDDNLSEEKRkhYLT------------IIEtettrlsklsQ 188
Cdd:PRK09467 216 NQMAAGIKQLEDDRTLLMAGVSHDLRTPLTRIR-----LATEMMSEEDG--YLAesinkdieecnaIIE----------Q 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 189 NLLKLTLLESEEYTPEKVNyrldqQLKQIVLNSEPLWdEKEIELDLDLEKVHITADQESMSQVWINLIYNSIKFtpSGGT 268
Cdd:PRK09467 279 FIDYLRTGQEMPMEMADLN-----ALLGEVIAAESGY-EREIETALQPGPIEVPMNPIAIKRALANLVVNAARY--GNGW 350
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 269 ITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFYKADSSRNRAygGSGLGLAIVKKVLDLHRGEIKV-ESEEGnGTEF 347
Cdd:PRK09467 351 IKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARGSS--GTGLGLAIVKRIVDQHNGKVELgNSEEG-GLSA 427
|
....*
gi 657628659 348 TVCIP 352
Cdd:PRK09467 428 RAWLP 432
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
123-352 |
6.57e-20 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 89.37 E-value: 6.57e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 123 MTDELN--AMEKMRQEFVSNVSHEIQSPLTSIKG----FARALQDDNLSEekrkhYLTIIETETTRLSKLSQNLLKltll 196
Cdd:PRK11073 117 LSQEQLqhAQQVAARDLVRGLAHEIKNPLGGLRGaaqlLSKALPDPALTE-----YTKVIIEQADRLRNLVDRLLG---- 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 197 eseeytPEKVNYRLDQQLKQIV-----LNSEPLWDEKEIELDLDLEKVHITADQESMSQVWINLIYNSIK-FTPSGGTIT 270
Cdd:PRK11073 188 ------PQRPGTHVTESIHKVAervvqLVSLELPDNVRLIRDYDPSLPELAHDPDQIEQVLLNIVRNALQaLGPEGGTIT 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 271 I------QLN----EYEKAVEVCIRDSGIGISEEQKQHIFerfYKADSSRNrayGGSGLGLAIVKKVLDLHRGEIKVESE 340
Cdd:PRK11073 262 LrtrtafQLTlhgeRYRLAARIDIEDNGPGIPPHLQDTLF---YPMVSGRE---GGTGLGLSIARNLIDQHSGKIEFTSW 335
|
250
....*....|..
gi 657628659 341 EGNgTEFTVCIP 352
Cdd:PRK11073 336 PGH-TEFSVYLP 346
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
3-356 |
3.10e-19 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 87.98 E-value: 3.10e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 3 RRERMNKVKILKVIGAIIALFSFLTIIWSIAFYVASSILDALEINVSPFVTFLISDMVGFVFIVLIWVLIGV-------L 75
Cdd:COG3290 2 LLLLLLLLLLLILLILILILLLLLLIILLLILLLVLLLLLFLLFVIILLLLLLILLLILLLLLLLLLAALLLklleeiaR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 76 MRPKREAMIWTIIEPIQKIAKGDFSVKIRNEEKYDGEIGVLVKSINDMTDELNAMEKMRQEFVSNVSHEI--QSPLTS-- 151
Cdd:COG3290 82 LVEEREAVLESIREGVIAVDRDGRITLINDAARRLLGLDAIGRPIDEVLAEVLETGERDEEILLNGRVLVvnRVPIRDdg 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 152 -IKGFARALQDDNlSEEKRKHYLTIIETETTRLSKLS---QNLLK--LTLLESEEYtpEKVNYRLDQQLKQIVLNSEPLW 225
Cdd:COG3290 162 rVVGAVATFRDRT-ELERLEEELEGVKELAEALRAQRhdfRNHLHtiSGLLQLGEY--DEALEYIDEISEELQELIDSLL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 226 D-------------------EKEIELDLDLEKV--HITADQESMSQVWINLIYNSI----KFTPSGGTITIQLNEYEKAV 280
Cdd:COG3290 239 SrignpvlaalllgkaararERGIDLTIDIDSDlpDLPLSDTDLVTILGNLLDNAIeaveKLPEEERRVELSIRDDGDEL 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 657628659 281 EVCIRDSGIGISEEQKQHIFERFYkadSSRNRayGGSGLGLAIVKKVLDLHRGEIKVESEEGNGTEFTVCIPKYKE 356
Cdd:COG3290 319 VIEVEDSGPGIPEELLEKIFERGF---STKLG--EGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
244-347 |
7.86e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 80.58 E-value: 7.86e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 244 DQESMSQVWINLIYNSIKFTPSGGTITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFYkadsSRNRAYGG---SGLG 320
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFY----SLPRPHSGqksTGLG 76
|
90 100
....*....|....*....|....*..
gi 657628659 321 LAIVKKVLDLHRGEIKVESEEGNGTEF 347
Cdd:cd16945 77 LAFVQEVAQLHGGRITLRNRPDGVLAF 103
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
248-352 |
4.40e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 78.58 E-value: 4.40e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 248 MSQVWINLIYNSIKFTPSGGTITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFYKADSSRNRayGGSGLGLAIVKKV 327
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNT--EGAGLGLSIAKAI 78
|
90 100
....*....|....*....|....*
gi 657628659 328 LDLHRGEIKVESeEGNGTEFTVCIP 352
Cdd:cd16923 79 IELHGGSASAEY-DDNHDLFKVRLP 102
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
250-352 |
4.76e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 78.59 E-value: 4.76e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 250 QVWINLIYNSIK----FTPSGGTITIQLNEYEK-AVEVCIRDSGIGISEEQKQHIFERFYKADSSrnraygGSGLGLAIV 324
Cdd:cd16920 3 QVLINLVRNGIEamseGGCERRELTIRTSPADDrAVTISVKDTGPGIAEEVAGQLFDPFYTTKSE------GLGMGLSIC 76
|
90 100
....*....|....*....|....*...
gi 657628659 325 KKVLDLHRGEIKVESEEGNGTEFTVCIP 352
Cdd:cd16920 77 RSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
1-353 |
5.71e-18 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 83.86 E-value: 5.71e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 1 MRRRermnkvkILKVIGAIIALFSFLTIIW-------SIAFYVASSiLDA--------LEIN---VSPFVTFLIsdMVGF 62
Cdd:PRK10755 4 LRRR-------LLLTIGLILLVFQLISVFWlwhesteQIQLLVQAT-LSArnndehvmKEIReavASLLVPSLV--MVSL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 63 VFIVLIWvligvlmrpkreAMIWtIIEPIQKIAKgdfSVKIRNEEKYD--------GEIGVLVKSINDMTDELNamEKMR 134
Cdd:PRK10755 74 TLLICFQ------------AVRW-ITRPLAELQK---ELEARTADNLTpiaihsstLEIEAVTSALNQLVSRLT--STLD 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 135 QE--FVSNVSHEIQSPLTSIKgfaralqddnLSEE--KRKHyltIIETET--TRLSKLSQNLLKLTLLEseeytpekvny 208
Cdd:PRK10755 136 QErlFTADVAHELRTPLAGIR----------LHLEllEKQH---HIDVAPliARLDQMMHTVEQLLQLA----------- 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 209 RLDQQL-----KQIVLNSE---PLWDEkeieLDLDLEKVHITAD-QESMSQVWI------------NLIYNSIKFTPSGG 267
Cdd:PRK10755 192 RAGQSFssghyQTVKLLEDvilPSQDE----LSEMLEQRQQTLLlPESAADITVqgdatllrlllrNLVENAHRYSPEGS 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 268 TITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFYKADSSrnraYGGSGLGLAIVKKVLDLHRGEIKVES-EEGNGTE 346
Cdd:PRK10755 268 TITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMDSR----YGGIGLGLSIVSRITQLHHGQFFLQNrQERSGTR 343
|
....*..
gi 657628659 347 FTVCIPK 353
Cdd:PRK10755 344 AWVWLPK 350
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
248-352 |
6.23e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 78.24 E-value: 6.23e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 248 MSQVWINLIYNSIKFTPSggTITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFYKADSSRNRAYGGSGLGLAIVKKV 327
Cdd:cd16939 1 MARALDNLLRNALRYAHR--TVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRV 78
|
90 100
....*....|....*....|....*
gi 657628659 328 LDLHRGEIKVESEEGNGTEFTVCIP 352
Cdd:cd16939 79 ALWHGGHVECDDSELGGACFRLTWP 103
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
244-352 |
8.28e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 78.10 E-value: 8.28e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 244 DQESMSQVWINLIYNSIKFTPSGGTITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFYKADSSRNrAYGGSGLGLAI 323
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRN-FQESTGMGLYL 80
|
90 100
....*....|....*....|....*....
gi 657628659 324 VKKVLDLHRGEIKVESEEGNGTEFTVCIP 352
Cdd:cd16948 81 VKKLCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
244-351 |
2.60e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 76.73 E-value: 2.60e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 244 DQESMSQVWINLIYNSIKFTPSGGTITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFYKADSSRNRAyGGSGLGLAI 323
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSG-GHYGMGLYI 79
|
90 100
....*....|....*....|....*...
gi 657628659 324 VKKVLDLHRGEIKVESEEGNGTEFTVCI 351
Cdd:cd16975 80 AKNLVEKHGGSLIIENSQKGGAEVTVKI 107
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
229-352 |
6.18e-17 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 82.03 E-value: 6.18e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 229 EIELDLDLEKVHITADQESMSQVWINLIYNSIKFTPSGGTITIQLN------------------EYekaVEVCIRDSGIG 290
Cdd:PRK13837 542 ELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSraklrapkvlshgvlppgRY---VLLRVSDTGAG 618
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 657628659 291 ISEEQKQHIFERFYkadSSRNrayGGSGLGLAIVKKVLDLHRGEIKVESEEGNGTEFTVCIP 352
Cdd:PRK13837 619 IDEAVLPHIFEPFF---TTRA---GGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLP 674
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
248-352 |
7.05e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 72.48 E-value: 7.05e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 248 MSQVWINLIYNSIKFtpSGGTITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFYKADSSRNraYGGSGLGLAIVKKV 327
Cdd:cd16950 1 LKRVLSNLVDNALRY--GGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRI 76
|
90 100
....*....|....*....|....*
gi 657628659 328 LDLHRGEIKVESEEGNGTEFTVCIP 352
Cdd:cd16950 77 SDAHGGSLTLANRAGGGLCARIELP 101
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
248-352 |
2.01e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 71.45 E-value: 2.01e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 248 MSQVWINLIYNSIKFTP-SGGTITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFYkADSSRNRAYG-GSGLGLAIVK 325
Cdd:cd16953 1 LGQVLRNLIGNAISFSPpDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFGqHSGLGLSISR 79
|
90 100 110
....*....|....*....|....*....|.
gi 657628659 326 KVLDLHRGEIKVESEEGN----GTEFTVCIP 352
Cdd:cd16953 80 QIIEAHGGISVAENHNQPgqviGARFTVQLP 110
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
254-352 |
5.63e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 70.01 E-value: 5.63e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 254 NLIYNSIKFT----PSGGTITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFYKADSSRNRayggsGLGLAIVKKVLD 329
Cdd:cd16915 7 NLIDNALDALaatgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGER-----GIGLALVRQSVE 81
|
90 100
....*....|....*....|...
gi 657628659 330 LHRGEIKVESEEGNGTEFTVCIP 352
Cdd:cd16915 82 RLGGSITVESEPGGGTTFSIRIP 104
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
137-352 |
5.64e-15 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 76.10 E-value: 5.64e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 137 FVSNVSHEIQSPLTSIKGFARALQDDNLSEEKRKHYLTIIETETTRLSKLSqNLLKLTLLES---------EEYTPEKVn 207
Cdd:PRK11466 447 FLAAMSHEIRTPLYGILGTAQLLADNPALNAQRDDLRAITDSGESLLTILN-DILDYSAIEAggknvsvsdEPFEPRPL- 524
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 208 yrLDQQLKQIvlnsEPLWDEKEIELDLDLEKVHITA---DQESMSQVWINLIYNSIKFTPSgGTITIQLNEYEKAVEVCI 284
Cdd:PRK11466 525 --LESTLQLM----SGRVKGRPIRLATDIADDLPTAlmgDPRRIRQVITNLLSNALRFTDE-GSIVLRSRTDGEQWLVEV 597
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 657628659 285 RDSGIGISEEQKQHIFERFYKADSSRnrayGGSGLGLAIVKKVLDLHRGEIKVESEEGNGTEFTVCIP 352
Cdd:PRK11466 598 EDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLP 661
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
12-356 |
1.71e-14 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 74.28 E-value: 1.71e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 12 ILKVIGAIIALFSFLTIIWSIAFYVASSILDAlEINVSPFVTFLISDMVGFVFIVLIWVLIGVLMRPkreamIWTIIEPI 91
Cdd:COG2972 119 LLILGLLLIILLLLSLLGWTLVSLIPKSELFR-GLFSLRRLILLIILLLLLLALLLSYLLSRSITRP-----IKRLKKAM 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 92 QKIAKGDFsvkIRNEEKYDGEIGVLVKSINDMTDELNAMEKMRQEFVSNVSH-EIQS------P------LTSIKGFARA 158
Cdd:COG2972 193 KKVEKGDL---VRLEVSGNDEIGILARSFNEMVERIKELIEEVYELELEKKEaELKAlqaqinPhflfntLNSIRWLAEL 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 159 LQDDNLSEekrkhyltIIEtettRLSKLsqnlLKLTLLESEEYTPekvnyrLDQQLKqivlnseplwdekEIELDLDLEK 238
Cdd:COG2972 270 EDPEEAEE--------MLE----ALSKL----LRYSLSKGDELVT------LEEELE-------------LIKSYLEIQK 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 239 --------VHITADQESMSQVWINL---------IYNSIKFTPSGGTITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFE 301
Cdd:COG2972 315 lrfgdrleVEIEIDEELLDLLIPKLilqplvenaIEHGIEPKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLE 394
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 657628659 302 RFYKADSsrnraygGSGLGLAIVKKVLDLHRGE---IKVESEEGNGTEFTVCIPKYKE 356
Cdd:COG2972 395 ELSSKGE-------GRGIGLRNVRERLKLYYGEeygLEIESEPGEGTTVTIRIPLEEE 445
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
131-194 |
2.39e-14 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 66.85 E-value: 2.39e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 657628659 131 EKMRQEFVSNVSHEIQSPLTSIKGFARALQDDNLSEEKRKHYLTIIETETTRLSKLSQNLLKLT 194
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLS 64
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
133-199 |
1.23e-13 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 64.93 E-value: 1.23e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 657628659 133 MRQEFVSNVSHEIQSPLTSIKGFARALQDDNLSEEKRKhYLTIIETETTRLSKLSQNLLKLTLLESE 199
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQRE-YLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
248-352 |
1.87e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 65.88 E-value: 1.87e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 248 MSQVWINLIYNSIK-FTPSGGTI----------TIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFYkadSSRNrayGG 316
Cdd:cd16918 1 LIQVFLNLVRNAAQaLAGSGGEIilrtrtqrqvTLGHPRHRLALRVSVIDNGPGIPPDLQDTIFYPMV---SGRE---NG 74
|
90 100 110
....*....|....*....|....*....|....*.
gi 657628659 317 SGLGLAIVKKVLDLHRGEIKVESEEGNgTEFTVCIP 352
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
133-199 |
2.38e-13 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 64.12 E-value: 2.38e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 657628659 133 MRQEFVSNVSHEIQSPLTSIKGFARALQDDNLSEEKRKhYLTIIETETTRLSKLSQNLLKLTLLESE 199
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQRE-YLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
227-349 |
2.46e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 60.72 E-value: 2.46e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 227 EKEIELDLDLEKVH-ITADQESMSQVWINLIYNSIKFTPSGGTITIQLNEyeKAVEVCIRDSGIGISEEQKQHIFERFYK 305
Cdd:cd16954 16 RKGVSISLDISPELrFPGERNDLMELLGNLLDNACKWCLEFVEVTARQTD--GGLHLIVDDDGPGVPESQRSKIFQRGQR 93
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 657628659 306 ADSSRNraygGSGLGLAIVKKVLDLHRGEIKVESEEGNGTEFTV 349
Cdd:cd16954 94 LDEQRP----GQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEV 133
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
227-352 |
7.91e-11 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 63.01 E-value: 7.91e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 227 EKEIELDLDLEKVHITADQESMSQVWI----NLIYNSIKFTPS--GGTITIQLNEYEKAVEVCIRDSGIGISEEQKQHIF 300
Cdd:PRK11086 409 ELGITLIISEDSQLPDSGDEDQVHELItilgNLIENALEAVGGeeGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIF 488
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 657628659 301 ERFYKADSSrNRayggsGLGLAIVKKVLDLHRGEIKVESEEGNGTEFTVCIP 352
Cdd:PRK11086 489 DKGYSTKGS-NR-----GVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIP 534
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
250-352 |
1.36e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 58.16 E-value: 1.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 250 QVWINLIYNSIKFTPSGGTITIQL------NEYEKA---------VEVCIRDSGIGISEEQKQHIFERFYKadssrNRAY 314
Cdd:cd16919 3 LAILNLAVNARDAMPEGGRLTIETsnqrvdADYALNyrdlipgnyVCLEVSDTGSGMPAEVLRRAFEPFFT-----TKEV 77
|
90 100 110
....*....|....*....|....*....|....*....
gi 657628659 315 G-GSGLGLAIVKKVLDLHRGEIKVESEEGNGTEFTVCIP 352
Cdd:cd16919 78 GkGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
250-349 |
4.61e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 56.31 E-value: 4.61e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 250 QVWINLIYNSIKFTPS--GGTITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFYKAdssrnRAYG-GSGLGLAIVKK 326
Cdd:cd16976 3 QVLMNLLQNALDAMGKveNPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTT-----KPVGkGTGLGLSISYG 77
|
90 100
....*....|....*....|...
gi 657628659 327 VLDLHRGEIKVESEEGNGTEFTV 349
Cdd:cd16976 78 IVEEHGGRLSVANEEGAGARFTF 100
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
133-352 |
1.27e-09 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 59.56 E-value: 1.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 133 MRQEFVSNVSHEIQSPLTSIKGFARALQDDNLSEEKRKHYLTIIEtETTRLSKLSQNLLKLTLLESEEYTPEKVNYRLDQ 212
Cdd:PRK10618 449 ARKAFLQNIGDELKQPLQSLAQLAAQLRQTSDEEQQQPELDQLAE-QSDVLVRLVDNIQLLNMLETQDWKPEQELFSLQD 527
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 213 QLKQIVLNSEPLWDEKEIEL----DLDLEKVHItADQESMSQVWINLIYNSIKFTpSGGTITIQLN---EYEKAVEVCIR 285
Cdd:PRK10618 528 LIDEVLPEVLPAIKRKGLQLlihnHLKAEQLRI-GDRDALRKILLLLLNYAITTT-AYGKITLEVDqdeSSPDRLTIRIL 605
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 657628659 286 DSGIGISEEQKQHIfeRF-YKADSSRNRAYGGSGLGLAIVKKVLDLHRGEIKVESEEGNGTEFTVCIP 352
Cdd:PRK10618 606 DTGAGVSIKELDNL--HFpFLNQTQGDRYGKASGLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIHLK 671
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
244-352 |
4.57e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 53.70 E-value: 4.57e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 244 DQESMSQVWINLIYN---SIKFTPSG---GTITIQLNEYEKAVeVCIRDSGIGISEEQKQHIFERfYKADSSRnraygGS 317
Cdd:cd16944 1 DTTQISQVLTNILKNaaeAIEGRPSDvgeVRIRVEADQDGRIV-LIVCDNGKGFPREMRHRATEP-YVTTRPK-----GT 73
|
90 100 110
....*....|....*....|....*....|....*
gi 657628659 318 GLGLAIVKKVLDLHRGEIKVESEEGNGTEFTVCIP 352
Cdd:cd16944 74 GLGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
210-352 |
4.38e-07 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 51.44 E-value: 4.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 210 LDQQLKQIVLNSEPLWDEKEIELDLDLEKVHITADQ-ESMSQVwIN-LIYNSIKF---TPSGGTITIQLNEYEKAVEVCI 284
Cdd:COG3920 361 LRDYLRELLEPLRDSYGGRGIRIELDGPDVELPADAaVPLGLI-LNeLVTNALKHaflSGEGGRIRVSWRREDGRLRLTV 439
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 657628659 285 RDSGIGISEEqkqhiferfykADSSRnraygGSGLGLAIVKKVLDLHRGEIKVESEEgnGTEFTVCIP 352
Cdd:COG3920 440 SDNGVGLPED-----------VDPPA-----RKGLGLRLIRALVRQLGGTLELDRPE--GTRVRITFP 489
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
84-127 |
1.76e-06 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 44.36 E-value: 1.76e-06
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 657628659 84 IWTIIEPIQKIAKGDFSVKIrnEEKYDGEIGVLVKSINDMTDEL 127
Cdd:cd06225 4 LRRLTEAARRIAEGDLDVRV--PVRSKDEIGELARAFNQMAERL 45
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
88-339 |
1.83e-06 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 49.68 E-value: 1.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 88 IEPIQKIAKGDFSVKIrneeKYDG--EIGVLVKS-------INDMTDELNAMEKMRQ----------------------- 135
Cdd:COG4192 359 SDAMAAIAAGDLDVPI----PVDGndEIGRIARLlrvfrdqAIEKTQELETEIEERKrieknlrqtqdeliqaakmavvg 434
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 136 EFVSNVSHEIQSPLTSIKGF----ARALQDDNLseEKRKHYLTIIETETTRLSKLSQNLLKLTLLESEEYTPEKVNYRLD 211
Cdd:COG4192 435 QTMTSLAHELNQPLNAMSMYlfsaKKALEQENY--AQLPTSLDKIEGLIERMDKIIKSLRQFSRKSDTPLQPVDLRQVIE 512
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 212 QQLKQIVLNSEPLWDEKEIELDLDlekvhITADQESMSQVWINLIYNSIKFTPSGGTITIQLNEYEKAVEVCIRDSGIGI 291
Cdd:COG4192 513 QAWELVESRAKPQQITLHIPDDLM-----VQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGW 587
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 657628659 292 SEEQKqhIFERFYKADSSrnraygGSGLGLAIVKKVLDLHRGEIKVES 339
Cdd:COG4192 588 PLVDK--LFTPFTTTKEV------GLGLGLSICRSIMQQFGGDLYLAS 627
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
229-352 |
3.41e-06 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 47.69 E-value: 3.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 229 EIELDLDLEKVHITAD---------QESMSqvwinliyNSIKFtpSGGT-ITIQLNEYEKAVEVCIRDSGIGISEEQKqh 298
Cdd:COG4585 143 RVELDVDGDPDRLPPEvelalyrivQEALT--------NALKH--AGATrVTVTLEVDDGELTLTVRDDGVGFDPEAA-- 210
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 657628659 299 iferfykadssrnrayGGSGLGLAIVKKVLDLHRGEIKVESEEGNGTEFTVCIP 352
Cdd:COG4585 211 ----------------PGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLP 248
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
63-147 |
1.07e-05 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 47.32 E-value: 1.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 63 VFIVLIWVLIGVLMRPKREamiwtIIEPIQKIAKGDFSVKIrnEEKYDGEIGVLVKSINDMTDELNAMEKMRQEFVSNV- 141
Cdd:COG0840 194 LAIILALLLSRSITRPLRE-----LLEVLERIAEGDLTVRI--DVDSKDEIGQLADAFNRMIENLRELVGQVRESAEQVa 266
|
....*...
gi 657628659 142 --SHEIQS 147
Cdd:COG0840 267 saSEELAA 274
|
|
| HAMP |
pfam00672 |
HAMP domain; |
70-129 |
3.84e-05 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 40.69 E-value: 3.84e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 70 VLIGVLMRPkreamIWTIIEPIQKIAKGDFSVKIrnEEKYDGEIGVLVKSINDMTDELNA 129
Cdd:pfam00672 1 LLARRILRP-----LRRLAEAARRIASGDLDVRL--PVSGRDEIGELARAFNQMAERLRE 53
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
265-352 |
4.40e-05 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 42.59 E-value: 4.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 265 SGGTITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFykadssrnrayGGSGLGLAIVKKVLDlhrgEIKVESEEGnG 344
Cdd:COG2172 55 PDGPVEVELELDPDGLEIEVRDEGPGFDPEDLPDPYSTL-----------AEGGRGLFLIRRLMD----EVEYESDPG-G 118
|
....*...
gi 657628659 345 TEFTVCIP 352
Cdd:COG2172 119 TTVRLVKR 126
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
75-131 |
4.98e-05 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 40.31 E-value: 4.98e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 657628659 75 LMRPkreamIWTIIEPIQKIAKGDFSVKIrnEEKYDGEIGVLVKSINDMTDELNAME 131
Cdd:smart00304 3 LLRP-----LRRLAEAAQRIADGDLTVRL--PVDGRDEIGELARAFNEMADRLEETI 52
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
254-355 |
1.03e-04 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 44.05 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 254 NLIYN----SIKFTPSGGTITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERfykADSSRNRAYGGSGLGLAIVKKVLD 329
Cdd:PRK15053 439 NLLDNafeaSLRSDEGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQ---GVSTRADEPGEHGIGLYLIASYVT 515
|
90 100
....*....|....*....|....*.
gi 657628659 330 LHRGEIKVESEEGNGTEFTVCIPKYK 355
Cdd:PRK15053 516 RCGGVITLEDNDPCGTLFSIFIPKVK 541
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
277-339 |
1.52e-04 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 43.47 E-value: 1.52e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 657628659 277 EKAVEVCIRDSGIGISEEQKQHIFERFYKADSSRNraygGSGLGLAIVKKVLDLHRGEIKVES 339
Cdd:PRK10815 406 DEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYEGKISAGD 464
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
277-352 |
1.88e-04 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 41.80 E-value: 1.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 277 EKAVE--VCIRDSGIGISEEQ-KQHIFER-FYKADSSRNRAygGSGLGLAIVKKVLDLHRGEIKVESEEGNGTEFTVCIP 352
Cdd:cd16916 101 EKAIErgLITADEAATLSDDEvLNLIFAPgFSTAEQVTDVS--GRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
16-346 |
5.37e-04 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 42.02 E-value: 5.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 16 IGAIIALFSFLTIIWSIAFYVASSILDALEINVSPFVTFLIsdmvgfVFIVLIWVLIGVLMRPkreamIWTIIEPIQKIA 95
Cdd:COG2770 183 IAALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALLALL------LALLLALLLARRITRP-----LRRLAEAARRIA 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 96 KGDFSVKIrnEEKYDGEIGVLVKSINDMTDELNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQDDNLSEEKRKHYLTI 175
Cdd:COG2770 252 AGDLDVRI--PVSRKDEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALL 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 176 IETETTRLSKLSQNLLKLTLLESEEYTPEKVNYRLDQQLKQIVLNSEPLWDEKEIELDLDLEKVHITADQESMSQVWINL 255
Cdd:COG2770 330 LELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELAL 409
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 256 IYNSIKFTPSGGTITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFYKADSSRNRAYGGSGLGLAIVKKVLDLHRGEI 335
Cdd:COG2770 410 EELVLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALEL 489
|
330
....*....|.
gi 657628659 336 KVESEEGNGTE 346
Cdd:COG2770 490 LLLEEEEEAGA 500
|
|
| HATPase_Phy-like |
cd16932 |
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana ... |
244-343 |
5.78e-04 |
|
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana Phytochrome A, B, C, D and E; This family includes the histidine kinase-like ATPase (HATPase) domains of plant red/far-red photoreceptors, the phytochromes, and includes the Arabidopsis thaliana phytochrome family phyA-phyE. Following red light absorption, biologically inactive forms of phytochromes convert to active forms, which rapidly convert back to inactive forms upon far-red light irradiation. Phytochromes can be considered as having an N-terminal photosensory region to which a bilin chromophore is bound, and a C-terminal output region, which includes the HATPase domain represented here, and is involved in dimerization and presumably contributes to relaying the light signal to downstream signaling events.
Pssm-ID: 340409 [Multi-domain] Cd Length: 113 Bit Score: 39.18 E-value: 5.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 244 DQESMSQVWINLIYNSIKFTPS-GGTITIQLNEYEKAV---------EVCIRDSGIGISEEQKQHIFErfykadssRNRA 313
Cdd:cd16932 3 DQIRLQQVLADFLLNAVRFTPSpGGWVEIKVSPTKKQIgdgvhvihlEFRITHPGQGLPEELVQEMFE--------ENQW 74
|
90 100 110
....*....|....*....|....*....|
gi 657628659 314 YGGSGLGLAIVKKVLDLHRGEIKVESEEGN 343
Cdd:cd16932 75 TTQEGLGLSISRKLVKLMNGDVRYLREAGR 104
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
15-348 |
6.71e-04 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 41.41 E-value: 6.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 15 VIGAIIALFSFLTIIWSIAFYVASSILDALEINVSpfVTFLISDMVGFVFIVLIWVLIGVLMRPKREamiwtIIEPIQKI 94
Cdd:COG3850 84 LLLAALLSLLLLLLLLLLLLLLLLLLLLAAAINRK--LALLRLLLALLLALLLAYLLRRRIVRPLRR-----LTQAAERI 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 95 AKGDFSVKIrnEEKYDGEIGVLVKSINDMTDELNA----MEKMRQEFVSNVSHEIQSPLTSIKGFARALQDDNLSEEKR- 169
Cdd:COG3850 157 ARGDFDARV--PVSGRDELGTLARAFNRMADELQElyaeLEEEEELEAELELLALLDELLLLAALLLLLALLLALLLAAl 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 170 ------KHYLTIIETETTRLSKLSQNLLKLTLLESEEYTPEKVNYRLDQQLKQIVLNSEPLWDEKEIELDLDLEKVHITA 243
Cdd:COG3850 235 laalllLLLLQDALAESELLALNILAGLLELLLALLLLLLASALLLLELELLALLLELVELLALAAAEEALLLLVELAAL 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 244 DQESMSQVWINLIYNSIKFTPSGGTITIQLNEYEKAVEVCIRDSGIGISEEQKQHIFERFYKADSSRNRAYGGSGLGLAI 323
Cdd:COG3850 315 LLLLLLQAIANASLLLIALASVVAALLELASILALQAALEAAAAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASE 394
|
330 340
....*....|....*....|....*
gi 657628659 324 VKKVLDLHRGEIKVESEEGNGTEFT 348
Cdd:COG3850 395 GAAGQGAGLVDVEGGVAGEGGLVVL 419
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
224-345 |
1.98e-03 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 40.04 E-value: 1.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 224 LWDEKEIELDL--DLEKVHItaDQESMSQVWINLIYNSIKFTPSGGTITIQLNEYEKA---------------VEVCIRD 286
Cdd:PRK13557 254 LGDAVTIETDLapDLWNCRI--DPTQAEVALLNVLINARDAMPEGGRVTIRTRNVEIEdedlamyhglppgryVSIAVTD 331
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 657628659 287 SGIGISEEQKQHIFERFY--KADSSrnraygGSGLGLAIVKKVLDLHRGEIKVESEEGNGT 345
Cdd:PRK13557 332 TGSGMPPEILARVMDPFFttKEEGK------GTGLGLSMVYGFAKQSGGAVRIYSEVGEGT 386
|
|
| HATPase_ETR2_ERS2-EIN4-like |
cd16938 |
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related ... |
241-351 |
2.09e-03 |
|
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related domains; This family includes the histidine kinase-like ATPase domains (HATPase) of three out of the five receptors that recognize the plant hormone ethylene in Arabidopsis thaliana. These three proteins have been classified as belonging to subfamily 2: ETR2, ERS2, and EIN4. They lack most of the motifs characteristic of histidine kinases, and EIN4 is the only one in this group containing the conserved histidine that is phosphorylated in two-component and phosphorelay systems. This family also includes the HATPase domains of Escherichia coli RcsD phosphotransferase which is a component of the Rcs-signaling system, a complex multistep phosphorelay involving five proteins, and is involved in many transcriptional networks such as cell division, biofilm formation, and virulence, among others. Also included is Schizosaccharomyces pombe Mak3 (Phk1) which participates in a multi-step two-component related system which regulates H2O2-induced activation of the Sty1 stress-activated protein kinase pathway. Most proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a GAF sensor domain; most are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340415 [Multi-domain] Cd Length: 133 Bit Score: 37.82 E-value: 2.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 241 ITADQESMSQVWINLIYNSIKFTPSGGTITIQ-------LNEYEKAV----------EVCIRdSGIGISEEQKQHIFERF 303
Cdd:cd16938 5 VVGDERRVFQVLLHMLGNLLKMRNGGGNITFRvfleggsEDRSDRDWgpwrpsmsdeSVEIR-FEVEINDSGSPSIESAS 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 657628659 304 YKADSSR--NRAYGGSGLGLAIVKKVLDLHRGEIKVESEEGNGTEFTVCI 351
Cdd:cd16938 84 MRNSLNRryNLSELGEHLSFSICKQLVQLMGGNIWIVPGSGLGTTMSLLL 133
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
316-352 |
2.79e-03 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 39.39 E-value: 2.79e-03
10 20 30
....*....|....*....|....*....|....*..
gi 657628659 316 GSGLGLAIVKKVLDLHRGEIKVESEEGNGTEFTVCIP 352
Cdd:COG0643 381 GRGVGMDVVKTNIEALGGTIEIESEPGKGTTFTLRLP 417
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
245-352 |
7.83e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 35.22 E-value: 7.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628659 245 QESMSqvwinliyNSIKFTPsGGTITIQLNEYEKAVEVCIRDSGIGISEEQKQhiferfykadssrnrayGGSGLGLAIV 324
Cdd:cd16917 6 QEALT--------NALKHAG-ASRVRVTLSYTADELTLTVVDDGVGFDGPAPP-----------------GGGGFGLLGM 59
|
90 100
....*....|....*....|....*...
gi 657628659 325 KKVLDLHRGEIKVESEEGNGTEFTVCIP 352
Cdd:cd16917 60 RERAELLGGTLTIGSRPGGGTRVTARLP 87
|
|
| |
