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Conserved domains on  [gi|657628668|ref|WP_029439376|]
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MULTISPECIES: homoserine kinase [Bacillus]

Protein Classification

homoserine kinase( domain architecture ID 11479451)

homoserine kinase catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate

CATH:  3.30.230.10|3.30.70.890
EC:  2.7.1.39
Gene Ontology:  GO:0016310|GO:0009088|GO:0004413|GO:0005737|GO:0005524
PubMed:  11188689|11535056
SCOP:  4001303|4000959

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK01212 PRK01212
homoserine kinase; Provisional
 1-289 4.67e-124

homoserine kinase; Provisional


:

Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 356.38  E-value: 4.67e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668   1 MIPLSIRVPASTANVGPGFDSVGIALSLYLHVVVKEKSN-----KWQVIHSFDESIPTD-DKNLIVSTACKVSPSLS--- 71
Cdd:PRK01212   1 MMMVKVRVPATSANLGPGFDSLGLALSLYDEVLVGDVVSveaefSIEVIGEGADKLPLDpEKNLVYQAALKFLEKLGkpp 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668  72 PHIIEVTSNIPLTRGLGSSASAIVAGIELANQLGKLNLTTDQKVQIATNFEGHPDNVAASILGGTVIGALDGKNVSVVRI 151
Cdd:PRK01212  81 GLRIELEKNIPLGRGLGSSAASIVAGLVAANELAGLPLSKEELLQLATEGEGHPDNVAPALLGGLVLALEENGVISVKIP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668 152 ESKELGVISLIPNEELNTDESRSVLPEVFPFHEAVKASAISNVLVAALCQKKWEVVGEMMErDHFHEPYRLELVPLLPSI 231
Cdd:PRK01212 161 VFDDLKWVVAIPNIELSTAEARAVLPKQYSLKDAVFNSSRAALLVAALYTGDYELAGRAMK-DVLHEPYRAKLIPGFAEV 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 657628668 232 RKCAKEFGAYGTALSGAGPSIFILTPYEKRQEIAEQLARVFT---SMKVCELEIDHRGITV 289
Cdd:PRK01212 240 RQAALEAGALGAGISGAGPTVFALCDKEDAEKVADALQKAFLqgiEGFVHVLRLDTAGARV 300
 
Name Accession Description Interval E-value
PRK01212 PRK01212
homoserine kinase; Provisional
 1-289 4.67e-124

homoserine kinase; Provisional


Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 356.38  E-value: 4.67e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668   1 MIPLSIRVPASTANVGPGFDSVGIALSLYLHVVVKEKSN-----KWQVIHSFDESIPTD-DKNLIVSTACKVSPSLS--- 71
Cdd:PRK01212   1 MMMVKVRVPATSANLGPGFDSLGLALSLYDEVLVGDVVSveaefSIEVIGEGADKLPLDpEKNLVYQAALKFLEKLGkpp 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668  72 PHIIEVTSNIPLTRGLGSSASAIVAGIELANQLGKLNLTTDQKVQIATNFEGHPDNVAASILGGTVIGALDGKNVSVVRI 151
Cdd:PRK01212  81 GLRIELEKNIPLGRGLGSSAASIVAGLVAANELAGLPLSKEELLQLATEGEGHPDNVAPALLGGLVLALEENGVISVKIP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668 152 ESKELGVISLIPNEELNTDESRSVLPEVFPFHEAVKASAISNVLVAALCQKKWEVVGEMMErDHFHEPYRLELVPLLPSI 231
Cdd:PRK01212 161 VFDDLKWVVAIPNIELSTAEARAVLPKQYSLKDAVFNSSRAALLVAALYTGDYELAGRAMK-DVLHEPYRAKLIPGFAEV 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 657628668 232 RKCAKEFGAYGTALSGAGPSIFILTPYEKRQEIAEQLARVFT---SMKVCELEIDHRGITV 289
Cdd:PRK01212 240 RQAALEAGALGAGISGAGPTVFALCDKEDAEKVADALQKAFLqgiEGFVHVLRLDTAGARV 300
ThrB COG0083
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ...
 4-292 5.95e-117

Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 439853 [Multi-domain]  Cd Length: 302  Bit Score: 338.23  E-value: 5.95e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668   4 LSIRVPASTANVGPGFDSVGIALSLYLHVVVKE-KSNKWQVIHS--FDESIPTDDKNLIVSTACKV----SPSLSPHIIE 76
Cdd:COG0083    3 VKVRVPATSANLGPGFDSLGLALSLYDEVEVERsDEPGLEIEIEgeGADELPTDEDNLVYQAALALleklGKEPPGLRIE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668  77 VTSNIPLTRGLGSSASAIVAGIELANQLGKLNLTTDQKVQIATNFEGHPDNVAASILGGTVIGALDGKNVSVVRIE-SKE 155
Cdd:COG0083   83 IEKGIPLGRGLGSSAAAIVAGLVAANALLGLPLSKEELLELATEGEGHPDNVAPALLGGLVLSRSDGEPVRVVRLPvPPD 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668 156 LGVISLIPNEELNTDESRSVLPEVFPFHEAVKASAISNVLVAALCQKKWEVVGEMMErDHFHEPYRLELVPLLPSIRKCA 235
Cdd:COG0083  163 LKAVVVIPDFELSTKEARAVLPKQVPLKDAVFNSSRAALLVAALATGDYELLGRAME-DRLHEPYRAKLIPGFDEVKEAA 241

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 657628668 236 KEFGAYGTALSGAGPSIFILTPYEKRQEIAEQLARVFTSM----KVCELEIDHRGITVNKE 292
Cdd:COG0083  242 LEAGALGAGISGAGPTVLALADDEEAEAVAEAMKAAFAEAgidaRVYVLKIDNEGARVLES 302
thrB TIGR00191
homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine ...
 4-289 6.08e-80

homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine kinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.P.aeruginosa homoserine kinase seems not to be homologous (see PROSITE:PDOC0054) [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 129295 [Multi-domain]  Cd Length: 302  Bit Score: 244.23  E-value: 6.08e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668    4 LSIRVPASTANVGPGFDSVGIALSLYLHVVVKE---KSNKWQVIHS---FDESIPTD-DKNLIVSTACKVSPSL----SP 72
Cdd:TIGR00191   1 FRVKVPASSANLGPGFDVLGAALSLYLGLTVTDvvaQESDDTEIEAegeGVEKIPTEpTDNLIYQVAKRFLDQLgirmPP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668   73 HIIEVTSNIPLTRGLGSSASAIVAGIELANQLGKLNLTTDQKVQIATNFEGHPDNVAASILGGTVIGALDGKNVSVVRIE 152
Cdd:TIGR00191  81 VKVTLEKNIPLGRGLGSSAAAIVAALAAANELCGLPLSKERLLDYASELEGHPDNVAPALLGGFQLAFVEDDKLEVLKIP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668  153 SK-ELGVISLIPNEELNTDESRSVLPEVFPFHEAVKASAISNVLVAALCQKKWEVVGEMMeRDHFHEPYRLELVPLLPSI 231
Cdd:TIGR00191 161 IFsKLDWVLAIPNIEVSTAEARAVLPKAYPRQDLVFNLSHLAGLVHAIYQKKPDLGAIMM-KDRIHQPYRESLIPNLFKI 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 657628668  232 RKCAKEFGAYGTALSGAGPSIFILTP----YEKRQEIAEQLARVFTSMKVCELEIDHRGITV 289
Cdd:TIGR00191 240 KQAALEKGAYGITISGSGPTILAMADeefaEQKEQDLLEVLHKQGIEGTVHVLDFDNDGARV 301
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 75-135 1.20e-11

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 59.10  E-value: 1.20e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 657628668   75 IEVTSNIPLTRGLGSSASAIVAGIELANQLG-----KLNLTTDQKVQIAtnfEGHPDNVAASILGG 135
Cdd:pfam00288   2 IEIESNIPLGAGLGSSAALAVALLLALNELFglplaKLALEAEELAGGG---RGGGMDVAASLYGG 64
 
Name Accession Description Interval E-value
PRK01212 PRK01212
homoserine kinase; Provisional
 1-289 4.67e-124

homoserine kinase; Provisional


Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 356.38  E-value: 4.67e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668   1 MIPLSIRVPASTANVGPGFDSVGIALSLYLHVVVKEKSN-----KWQVIHSFDESIPTD-DKNLIVSTACKVSPSLS--- 71
Cdd:PRK01212   1 MMMVKVRVPATSANLGPGFDSLGLALSLYDEVLVGDVVSveaefSIEVIGEGADKLPLDpEKNLVYQAALKFLEKLGkpp 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668  72 PHIIEVTSNIPLTRGLGSSASAIVAGIELANQLGKLNLTTDQKVQIATNFEGHPDNVAASILGGTVIGALDGKNVSVVRI 151
Cdd:PRK01212  81 GLRIELEKNIPLGRGLGSSAASIVAGLVAANELAGLPLSKEELLQLATEGEGHPDNVAPALLGGLVLALEENGVISVKIP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668 152 ESKELGVISLIPNEELNTDESRSVLPEVFPFHEAVKASAISNVLVAALCQKKWEVVGEMMErDHFHEPYRLELVPLLPSI 231
Cdd:PRK01212 161 VFDDLKWVVAIPNIELSTAEARAVLPKQYSLKDAVFNSSRAALLVAALYTGDYELAGRAMK-DVLHEPYRAKLIPGFAEV 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 657628668 232 RKCAKEFGAYGTALSGAGPSIFILTPYEKRQEIAEQLARVFT---SMKVCELEIDHRGITV 289
Cdd:PRK01212 240 RQAALEAGALGAGISGAGPTVFALCDKEDAEKVADALQKAFLqgiEGFVHVLRLDTAGARV 300
ThrB COG0083
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ...
 4-292 5.95e-117

Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 439853 [Multi-domain]  Cd Length: 302  Bit Score: 338.23  E-value: 5.95e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668   4 LSIRVPASTANVGPGFDSVGIALSLYLHVVVKE-KSNKWQVIHS--FDESIPTDDKNLIVSTACKV----SPSLSPHIIE 76
Cdd:COG0083    3 VKVRVPATSANLGPGFDSLGLALSLYDEVEVERsDEPGLEIEIEgeGADELPTDEDNLVYQAALALleklGKEPPGLRIE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668  77 VTSNIPLTRGLGSSASAIVAGIELANQLGKLNLTTDQKVQIATNFEGHPDNVAASILGGTVIGALDGKNVSVVRIE-SKE 155
Cdd:COG0083   83 IEKGIPLGRGLGSSAAAIVAGLVAANALLGLPLSKEELLELATEGEGHPDNVAPALLGGLVLSRSDGEPVRVVRLPvPPD 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668 156 LGVISLIPNEELNTDESRSVLPEVFPFHEAVKASAISNVLVAALCQKKWEVVGEMMErDHFHEPYRLELVPLLPSIRKCA 235
Cdd:COG0083  163 LKAVVVIPDFELSTKEARAVLPKQVPLKDAVFNSSRAALLVAALATGDYELLGRAME-DRLHEPYRAKLIPGFDEVKEAA 241

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 657628668 236 KEFGAYGTALSGAGPSIFILTPYEKRQEIAEQLARVFTSM----KVCELEIDHRGITVNKE 292
Cdd:COG0083  242 LEAGALGAGISGAGPTVLALADDEEAEAVAEAMKAAFAEAgidaRVYVLKIDNEGARVLES 302
thrB TIGR00191
homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine ...
 4-289 6.08e-80

homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine kinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.P.aeruginosa homoserine kinase seems not to be homologous (see PROSITE:PDOC0054) [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 129295 [Multi-domain]  Cd Length: 302  Bit Score: 244.23  E-value: 6.08e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668    4 LSIRVPASTANVGPGFDSVGIALSLYLHVVVKE---KSNKWQVIHS---FDESIPTD-DKNLIVSTACKVSPSL----SP 72
Cdd:TIGR00191   1 FRVKVPASSANLGPGFDVLGAALSLYLGLTVTDvvaQESDDTEIEAegeGVEKIPTEpTDNLIYQVAKRFLDQLgirmPP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668   73 HIIEVTSNIPLTRGLGSSASAIVAGIELANQLGKLNLTTDQKVQIATNFEGHPDNVAASILGGTVIGALDGKNVSVVRIE 152
Cdd:TIGR00191  81 VKVTLEKNIPLGRGLGSSAAAIVAALAAANELCGLPLSKERLLDYASELEGHPDNVAPALLGGFQLAFVEDDKLEVLKIP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668  153 SK-ELGVISLIPNEELNTDESRSVLPEVFPFHEAVKASAISNVLVAALCQKKWEVVGEMMeRDHFHEPYRLELVPLLPSI 231
Cdd:TIGR00191 161 IFsKLDWVLAIPNIEVSTAEARAVLPKAYPRQDLVFNLSHLAGLVHAIYQKKPDLGAIMM-KDRIHQPYRESLIPNLFKI 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 657628668  232 RKCAKEFGAYGTALSGAGPSIFILTP----YEKRQEIAEQLARVFTSMKVCELEIDHRGITV 289
Cdd:TIGR00191 240 KQAALEKGAYGITISGSGPTILAMADeefaEQKEQDLLEVLHKQGIEGTVHVLDFDNDGARV 301
PTZ00299 PTZ00299
homoserine kinase; Provisional
 4-257 9.04e-33

homoserine kinase; Provisional


Pssm-ID: 140320  Cd Length: 336  Bit Score: 123.08  E-value: 9.04e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668   4 LSIRVPASTANVGPGFDSVGIALSLYLHVVVkEKSNKWQVIHSFD--ESIPTDDKNLIVSTACKV-----SPSLSPHIIE 76
Cdd:PTZ00299   8 VVLRVPATTANIGPAYDTLGMALSIFMELTV-EHADAFSMTVEGEgsEHISTDEDNMVVQACRLAfeeyaHKSMPPLKFI 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668  77 VTSNIPLTRGLGSSASAIVAGIELANQLGKLNLTTDQK---VQIATNFEGHPDNVAASILGGTVIG-ALDGKNVSVVRIE 152
Cdd:PTZ00299  87 MHSNIPYGCGCGSSSAAAVAGFVAGMKLCGLTMETENEealLQAIAKFEGHPDNAAPAIYGGIQLVyKKDNGRFLTYRVP 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668 153 SK-ELGVISLIPNE--ELNTDESRSVLPEVFPFHEAVKASAISNVLVAALCQKKWEVVGEMmeRDHFHEPYRLElvPLLP 229
Cdd:PTZ00299 167 TPpNLSVVLFVPHNkmKANTHVTRNLIPTSVSLEDAVFNISRTSILVLALSTGDLRMLKSC--SDKLHEQQRSD--ALFP 242

                        250       260       270
                 ....*....|....*....|....*....|.
gi 657628668 230 SIRKC---AKEFGAYGTALSGAGPSIFILTP 257
Cdd:PTZ00299 243 HFRPCvkaAREAGAHYAFLSGAGPSVCALVG 273
PLN02451 PLN02451
homoserine kinase
 9-272 7.08e-26

homoserine kinase


Pssm-ID: 215248  Cd Length: 370  Bit Score: 105.26  E-value: 7.08e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668   9 PASTANVGPGFDSVGIAL-SLYLHVVVKeksnkwqvihsFDESIPTDDKNL--IVSTACKVSpsLSPH------------ 73
Cdd:PLN02451  59 PATVANLGPGFDFLGCAVdGLGDFVTAR-----------VDPGVRPGEVSIseITGDTGRLS--KDPLrncagiaaiatm 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668  74 ----------IIEVTSNIPLTRGLGSSASAIVAGIELANQLGKLNLTTDQKVQIATNFEG-----HPDNVAASILGGTV- 137
Cdd:PLN02451 126 kllgirsvglSLSLHKGLPLGSGLGSSAASAAAAAVAVNELFGSPLGKDDLVLAGLESEAkvsgyHADNIAPALMGGFVl 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668 138 IGALDGKNVSVVRIES-KELGVISLIPNEELNTDESRSVLPEVFPFHEAVKASAISNVLVAALCQKKWEVVGEMMERDHF 216
Cdd:PLN02451 206 IRSYEPLHLIPLRFPSaKDLFFVLVSPDFEAPTKKMRAALPKEIPMKHHVWNCSQAAALVAAILQGDAVLLGEALSSDKI 285

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 657628668 217 HEPYRLELVPLLPSIRKCAKEFGAYGTALSGAGPS-IFILTPYEKRQEIAEQLARVF 272
Cdd:PLN02451 286 VEPTRAPLIPGMEAVKKAALEAGAYGCTISGAGPTaVAVIDDEEKGEEVGERMVEAF 342
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 75-135 1.20e-11

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 59.10  E-value: 1.20e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 657628668   75 IEVTSNIPLTRGLGSSASAIVAGIELANQLG-----KLNLTTDQKVQIAtnfEGHPDNVAASILGG 135
Cdd:pfam00288   2 IEIESNIPLGAGLGSSAALAVALLLALNELFglplaKLALEAEELAGGG---RGGGMDVAASLYGG 64
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 21-249 3.57e-09

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 56.39  E-value: 3.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668  21 SVGIALSLYLHVVVKEKSNKWQVIHSFDESIPTDD-----------KNLIVSTACKVSPSLSPHIIEVTSNIPLTRGLGS 89
Cdd:COG1577   19 AIAVAVDRRATVTVEPSDDDKLRIESPDLGGTLDLdpladaalryiKAAIEAALEYLGLPLKGFDIEIDSEIPRKRGLGS 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668  90 SASAIVAGIELANQLGKLNLTTDQKVQIA--TNFEGHP-----DNvAASILGGtvigaldgknvsVVRIESKElGVISLI 162
Cdd:COG1577   99 SAAVAVAVIRALAAFYGVELSKEELFKLAleAEKIVHGnpsglDT-AASTYGG------------PIYYQRGD-RAEPLE 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668 163 PNEEL-----NTDESRS---VLPEV--------FPFHEAVKASA-ISNVLVAALCQKKWEVVGEMMERDHFHepyRLEL- 224
Cdd:COG1577  165 LPKNLplvvgDTGVPAStkeLVAKVrklkernpELYEAFLEEIGdLVEEAIEALEEGDLEALGELMNENHGL---LRALg 241

                        250       260
                 ....*....|....*....|....*..
gi 657628668 225 --VPLLPSIRKCAKEFGAYGTALSGAG 249
Cdd:COG1577  242 vsTPELDRLVEAARKAGALGAKLTGAG 268
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 18-249 1.44e-08

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 54.60  E-value: 1.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668   18 GFDSVGIALSLYLHVVVKEkSNKWQVIHS--FDESI---PTDDKNLIVSTACKVS----PSLSPHIIEVTSNIPLTRGLG 88
Cdd:TIGR00549  16 GEPAIAAPIPLRTTVTVIE-SSDGSFIESdlGRGSLddaPDELDGLKYVLAEFLSrfseLNPPPLEITIESEIPPGRGLG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668   89 SSASAIVAGIELANQLGKLNLTTDQKVQIATNFE----GHP---DNvAASILGGTVigaLDGKNVSVVRIESKELGVISL 161
Cdd:TIGR00549  95 SSAAVAVALIRALADYFGSELSKEELAELANEAEkiahGKPsgiDT-ATSTSGGPV---YFEKGEGEFTKLISLDGYFVI 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668  162 IpneelNTDESRS---------VLPEVFPfhEAVKAS-----AISNVLVAALCQKKWEVVGEMMERDHfhepyrlEL--- 224
Cdd:TIGR00549 171 A-----DTGVSGStkeavarvrQLLERFP--ELIDSImdaigELTLEAKAALQDGDVESLGELMNINQ-------GLlka 236

                         250       260
                  ....*....|....*....|....*....
gi 657628668  225 ----VPLLPSIRKCAKEFGAYGTALSGAG 249
Cdd:TIGR00549 237 lgvsHPKLDQLVEIARKAGALGAKLTGAG 265
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 195-272 4.93e-07

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 46.69  E-value: 4.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668  195 LVAALCQKKWEVVGEMMERDHF-HEP--YRLELVPLLPSIRKCAKEFGaYGTALSGA--GPSIFILTPYEKR-QEIAEQL 268
Cdd:pfam08544   1 LLEALLRGDLEELGKLLTESAEsLEPllVVGILPPELDELLEALLELG-LGAKLSGSggGPTVFALFKDEDDaEEVARAL 79


                  ....
gi 657628668  269 ARVF 272
Cdd:pfam08544  80 REAG 83
PRK03926 PRK03926
mevalonate kinase; Provisional
 53-266 5.11e-07

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 50.05  E-value: 5.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668  53 TDDKNLIVSTACKVSPSLSPH---IIEVTSNIPLTRGLGSSASAIVAGIELANQLGKLNLTTDQ------KVQIATNFEG 123
Cdd:PRK03926  53 TGEKHPYVSAAIEKMREEADKdgvTVSITSQIPVGSGLGSSAAVTVATIGALNRLLGLGLSLEEiaklghKVELLVQGAA 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668 124 HPDNVAASILGGTVIgALDGKNVSVVrieskELGVI-----SLIPNEEL--NTDESRSVLPEVF-PFHEAV-KASAISNV 194
Cdd:PRK03926 133 SPTDTYVSTMGGFVT-IPDRKKLPFP-----ECGIVvgytgSSGSTKELvaNVRKLKEEYPELIePILSSIgKISEKGEE 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668 195 LVaalCQKKWEVVGEMMERDHfhepyRL---------ELVPLLPSIRKCakefGAYGTALSGAGPS--IFILTPYEKRQE 263
Cdd:PRK03926 207 LI---LSGDYVSLGELMNINQ-----GLldalgvstkELSELIYAARTA----GALGAKITGAGGGgcMVALAAPEKQSE 274


                 ...
gi 657628668 264 IAE 266
Cdd:PRK03926 275 VAT 277
PduX COG4542
PduX protein involved in propanediol utilization and related proteins [Secondary metabolites ...
 75-274 7.76e-04

PduX protein involved in propanediol utilization and related proteins [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443608 [Multi-domain]  Cd Length: 286  Bit Score: 40.22  E-value: 7.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668  75 IEVTSNIPLTRGLGSSASAIVAGIELANQLGKLNLTTDQKVQIATNFEG-----HPDNVAASILGGTVIGALDgknvsvv 149
Cdd:COG4542   73 IELRSDIPVGKGMASSTADIAATARAVARALGKELSPEELARLAVAIEPtdstmFPGLVLFDHREGRVLEPLG------- 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668 150 riESKELGVISLIPNEELNTDE-SRSVLPEVFPFHEAVKASAIsNVLVAALCQKKWEVVGEMMERDHF----HEPYrlel 224
Cdd:COG4542  146 --PLPPLDILGLDSGGTVDTLAfNRRDLAELNRAEEPEIERAL-ALLREALRTGDLALLGEAATLSARanqrILPK---- 218

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668 225 vPLLPSIRKCAKEFGAYG--TALSG--AGpsifIL-----TPYEKR-QEIAEQLARVFTS 274
Cdd:COG4542  219 -PELEELLALAEELGALGvnVAHSGtvLG----LLfdpgdHDVEKLaEALRRRLLRLGYP 273
PRK14613 PRK14613
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
157-275 2.55e-03

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 173077 [Multi-domain]  Cd Length: 297  Bit Score: 38.73  E-value: 2.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657628668 157 GVISLIPnEELNTDESRSVLPEvfPFHEAVKA---SAISNVLVAALCQKKWEVVGEMMERDHfhEPYRLELVPLLPSIRK 233
Cdd:PRK14613 173 GILALTP-QVMNTGEMYALLKK--PLQESASQkngNTLSEDLISSLKVGDWVSLQGRLENDF--EPVAFQLHPELGVLKD 247

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 657628668 234 CAKEFGAYGTALSGAGPSIFILTP-YEKRQEIAEQLARVFTSM 275
Cdd:PRK14613 248 KFLEFGSSYCSLTGSGSSMYGLVQgLEIQEELLPRLRQEFSNL 290
PRK03817 PRK03817
galactokinase; Provisional
 75-118 2.85e-03

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 38.82  E-value: 2.85e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 657628668  75 IEVTSNIPLTRGLGSSASAIVAGIELANQLGKLNLTTDQKVQIA 118
Cdd:PRK03817  89 GKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLA 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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