|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10489 |
PRK10489 |
enterobactin transporter EntS; |
6-409 |
5.27e-149 |
|
enterobactin transporter EntS;
Pssm-ID: 236700 [Multi-domain] Cd Length: 417 Bit Score: 429.01 E-value: 5.27e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 6 KLVLDVDPLRTSREFRYIFTARVVSLFGLGFLVVAVPLQVYRLTGSTAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRV 85
Cdd:PRK10489 5 SWLLDLSLLKTHPAFRAVFIARFISIFGLGLLGVAVPVQIQMMTGSTLQVGLSVTLTGGAMFIGLMVGGVLADRYDRKKL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 86 IAVARGTAGVAFAVLALNAFLPDPKMWVVYVAAVIDGACGGISATALMAVTPSLLPREKMAAAGALMALTGDLGAMVGPA 165
Cdd:PRK10489 85 ILLARGTCGLGFIGLALNAFLPEPSLLAIYLLGLWDGFFGSLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 166 LGGVVIAAGGVGVAYALAAFTTAVTTFCITRLPSLPPTHVADESPLRSVLSGFRYASGNRVIGGVLVCGFVTMLLAGWSV 245
Cdd:PRK10489 165 LGGLLIAAGGVAWNYGLAAAGTFITLLPLLRLPALPPPPQPREHPLRSLLAGFRFLLASPVVGGIALLGGLLTMASAVRV 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 246 LVPEYATEVLGAGPSVVGLLYTAPAVGAVIGSLTSGWTGHLRRSGQVVFLLMAVSAAGLVGAGLTATVAVALLGLAAHGF 325
Cdd:PRK10489 245 LYPALADEVWQMGAAQIGLLYAAVPLGAALGALTSGWLAHSARPGLLMLLSTLGSFLAVGLFGLMPMWILAVLCLALFGY 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 326 GDALTDIVRYATVQKHTPDEYRGRIAAVWAAQVTAGASVGAVVAGAVAALVPISAALPAYGAVGLVITALLWATLRTLRR 405
Cdd:PRK10489 325 LSAISSLLQYTLLQTQTPDEMLGRINGLWTAQNVTGDAIGAALLGGLGAMMTPVASASASGFGLLIIGVLLLLVLGELRR 404
|
....
gi 657824794 406 LDEG 409
Cdd:PRK10489 405 FRQT 408
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
20-397 |
1.14e-52 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 180.50 E-value: 1.14e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 20 FRYIFTARVVSLFGLGFLVVAVPLQVYRLTGSTAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVARGTAGVAFAV 99
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 100 LALNAFLPDPKMWVVYVAAVIDGACGGISATALMAVTPSLLPREKMAAAGALMALTGDLGAMVGPALGGVVIAAGGVGVA 179
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 180 YALAAFTTAVTTFCITRLPSLPPTHVADESPL--RSVLSGFRYASGNRVIGGVLVCGFVTMLLAG-WSVLVPEYATEVLG 256
Cdd:cd06173 161 FAINALSFLLSALLLLFIRRPPPAAPGESSSLllRDLREGLRYLRRSPLLRLLLLALALFALLGGaLTVLLPLLAKEVLG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 257 AGPSVVGLLYTAPAVGAVIGSLTSGWTGHLRRSGQVVFLLMAVSAAGLVGAGLTATVAVALLGLAAHGFGDALTDIVRYA 336
Cdd:cd06173 241 GGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNT 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 657824794 337 TVQKHTPDEYRGRIAAVWAAQVTAGASVGAVVAGAVAALVPISAALPAYGAVGLVITALLW 397
Cdd:cd06173 321 LLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLL 381
|
|
| 2A0121 |
TIGR00900 |
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds] |
20-353 |
1.06e-28 |
|
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 162098 [Multi-domain] Cd Length: 365 Bit Score: 115.50 E-value: 1.06e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 20 FRYIFTARVVSLFGLGFLVVAVPLQVYRLTGSTAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVARGTAGVAFAV 99
Cdd:TIGR00900 1 FRLLFAAQLISLIGTAITQVALPLYVLAGTGSASVLSLAALAGMLPYVVLSPIAGALADRYDRKKVMIGADLIRAVLVAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 100 LALNAFLPDPKMWVVYVAAVIDGACGGISATALMAVTPSLLPREKMAAAGALMALTGDLGAMVGPALGGVVIAAGGVGVA 179
Cdd:TIGR00900 81 LPFVALLGGLNIWQVYVLAGILAIAQAFFTPAYQAMLPDLVPEEQLTQANSLSQAVRSLFYIVGPGIGGLMYATLGIKWA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 180 YALAA--FTTAVTTFCITRLPSLPPT--HVADESPLRSVLSGFRYASGNRVIGGVLVCGFVTMLL--AGWSVLVPEYATE 253
Cdd:TIGR00900 161 IWVDAvgFAISALLIVSVRIPELAASeiQALSNAVLRDTREGIKFVLKNPLLRTLLLLALLFNLVfaPAIVALFPYVQSK 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 254 VLGAGPSVVGLLYTAPAVGAVIGSLTSGWTGhlRRSGQVVFLLMAVSAAGLVGAGLTATVAVALLGLAAH---GFGDALT 330
Cdd:TIGR00900 241 YLGRGSTHYGWVLAAFGLGALLGALLLGLLG--RYFKRMALMTGAIFVIGLAILVVGLTPPNFPLFLVLWfaiGVGYGPI 318
|
330 340
....*....|....*....|...
gi 657824794 331 DIVRYATVQKHTPDEYRGRIAAV 353
Cdd:TIGR00900 319 NVPQGTLLQRRVPAELLGRVFGA 341
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
23-356 |
4.14e-24 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 102.36 E-value: 4.14e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 23 IFTARVVSLFGLGFLVVAVPLQVYRLTGSTAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVARGTAGVAFAVLAL 102
Cdd:COG2814 15 LALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 103 NaflpdPKMWVVYVAAVIDGACGGISATALMAVTPSLLPREKMAAAGALMALTGDLGAMVGPALGGVVIAAGGVGVAYAL 182
Cdd:COG2814 95 A-----PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 183 AAFTTAVTTFCITRLpsLPPTHVADESPLRSVLsgFRYASGNRVIGGVLVCGFVTMLLAGWSVLVPEYATEVLGAGPSVV 262
Cdd:COG2814 170 NAVLALLALLLLLRL--LPESRPAARARLRGSL--RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 263 GLLYTAPAVGAVIGSLTSGWTGHLRRSGQVVFLLMAVSAAGLVGAGLTATVAVALLGLAAHGFGDALTDIVRYATVQKHT 342
Cdd:COG2814 246 GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELA 325
|
330
....*....|....
gi 657824794 343 PDEYRGRIAAVWAA 356
Cdd:COG2814 326 PPEARGRASGLYNS 339
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
20-354 |
5.77e-22 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 97.90 E-value: 5.77e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 20 FRYIFTARVVSLFGLGFLVVAVPLQVYRLTGSTAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVARGTAGVAFAV 99
Cdd:pfam05977 12 FRVIWIASLASNLGTLMQDVAASWLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLLALVSTL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 100 LALNAFLPDPKMWVVYVAAVIDGACGGISATALMAVTPSLLPREKMAAAGALMALTGDLGAMVGPALGGVVIAAGGVGVA 179
Cdd:pfam05977 92 LTLLAGLGLLSPWLLLGLTFLGGIGTALMDPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVLLAAFGPAFT 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 180 YALAAFTTAVTTFCITRL-PSLPPTHVADESPLRSVLSGFRYASGNRVIGGVLVCGFVTML--LAGWSvLVPEYATEVLG 256
Cdd:pfam05977 172 FALNALSYFAVIAALWRWkRAAPASPLPRERIFGAVRAGLRFTAMSRELRSVLVRAFAFGLsaSAVWA-LLPLVARDLLD 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 257 AGPSVVGLLYTAPAVGAVIGSLTSGWTGHLRRSGQVVFLLMAVSAAGLVGAGLTATVAVALLGLAAHGFGDALTDIVRYA 336
Cdd:pfam05977 251 GDAIFYGILLGAVGVGAILGALSLPRLRERLGSDRLVLLASVVTALVLLSLALAPNLWLAIPVLLLGGAAWITALTTLNV 330
|
330
....*....|....*...
gi 657824794 337 TVQKHTPDEYRGRIAAVW 354
Cdd:pfam05977 331 AVQLSVPRWVRGRALAVY 348
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
23-354 |
2.33e-20 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 91.87 E-value: 2.33e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 23 IFTARVVSLFGLGFLVVAVPLQVYRLTGSTAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVarGTAGVAFAVLAL 102
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLL--GLLLLAVSTLLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 103 nAFLPDPkmWVVYVAAVIDGACGGISATALMAVTPSLLPREKMAAAGALMALTGDLGAMVGPALGGVVIAAGGV-GVAYA 181
Cdd:cd17325 79 -AFATSY--WQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYrAPFLV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 182 LAAFTTAVTTFCITRLPSLPPTHVADESPLRSVLSGFRYASGNRVIGGVLVCGFVTML-LAGWSVLVPEYATEVLGAGPS 260
Cdd:cd17325 156 CAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFaFGALEPFLPLYAAELGGLSPA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 261 VVGLLYTAPAVGAVIGSLTSGWTGHLRRSGQVVFLLMAVSAAGLVGAGLTATVAVALLGLAAHGFGDALTDIVRYATVQK 340
Cdd:cd17325 236 QIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLAD 315
|
330
....*....|....
gi 657824794 341 HTPDEYRGRIAAVW 354
Cdd:cd17325 316 IVPPEGRGTAMGLF 329
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
23-356 |
6.31e-18 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 84.39 E-value: 6.31e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 23 IFTARVVSLFGLGFLVVAVPLQVYR-LTGSTAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVARGTAGVAFAVLA 101
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEdLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 102 LNAflpdpKMWVVYVAAVIDGACGGISATALMAVTPSLLPREKMAAAGALMALTGDLGAMVGPALGGVVIAAGGVGVAYA 181
Cdd:pfam07690 81 FAS-----SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 182 LAAFTTAVTTFC--ITRLPSLPPTHVADESPLRSVLSGFRYASGNRVIGGVLVCGFVTMLLAGWSVLVPEYAtEVLGAGP 259
Cdd:pfam07690 156 ILAILSLLAAVLllLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQ-EVLGLSA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 260 SVVGLLYTAPAVGAVIGSLTSGWTGH---LRRSGQVVFLLMAVSAAGLVGAGLTATVAVALLGLAAHGFGDALTDIVRYA 336
Cdd:pfam07690 235 LLAGLLLGLGGLLGAIGRLLLGRLSDrlgRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNA 314
|
330 340
....*....|....*....|
gi 657824794 337 TVQKHTPDEYRGRIAAVWAA 356
Cdd:pfam07690 315 LVSDLAPKEERGTASGLYNT 334
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
51-349 |
1.89e-14 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 74.19 E-value: 1.89e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 51 STAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVARGTAGVAFAVLalnAFLPDPkmWVVYVAAVIDGACGGISAT 130
Cdd:cd17329 33 SASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALL---GFAHSP--WLFAIALVLTGFGGGLFEP 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 131 ALMAVTPSLLPREKMAAAGALMALTGDLGAMVGPALGGVVIAAGGVGVAYALAAFTTAVTTFCITRLPSLPPTHVADESP 210
Cdd:cd17329 108 ASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKT 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 211 lrSVLSGFRYASGNRVIGGVLVCGFVTMLL-AGWSVLVPEYATEVLGAGPSVVGLLYTAPAVGAVIGS-LTSGWTGHLRR 288
Cdd:cd17329 188 --EILRGYKIVLRDRAFLLFLLASFLISLIyFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQfPVARLVERFRL 265
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 657824794 289 SGQVVFlLMAVSAAGLVGAGLTATVAVALLGLAAHGFGDALTDIVRYATVQKHTPDEYRGR 349
Cdd:cd17329 266 RKILMI-GILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGS 325
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
23-326 |
1.23e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 71.86 E-value: 1.23e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 23 IFTARVVSLFGLGFLVVAVPLQVYRLTGSTAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVargtaGVAFAVLAL 102
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLI-----GLLIFALAT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 103 NAFLPDPKMWVVYVAAVIDGACGGISATALMAVTPSLLPREKMAAAGALMALTGDLGAMVGPALGGVVIAAGGVGVAYAL 182
Cdd:cd17489 76 LLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 183 AAFTTAVTTFCITRLPSLPPTHVADESPLRSVLSGFRYasgNRVIGGVLVCGFVTMLLAGWSVLVPEYATEVlgaGPSVV 262
Cdd:cd17489 156 AAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVE---KKVLPPALILFLASIAYGAISTFLPLYAAER---GISNA 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 657824794 263 GLLYTAPAVGAVIGSLTSGWTGHLRRSGQVVFLLMAVSAAGLVGAGLTATVAVALLGLAAHGFG 326
Cdd:cd17489 230 GLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLG 293
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
51-326 |
1.78e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 71.42 E-value: 1.78e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 51 STAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVARGTAGVAFAVLALNaflpdPKMWVVYVAAVIDGACGGISAT 130
Cdd:COG0738 41 SDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALA-----PSYPLLLLALFLLGLGLGLLDV 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 131 ALMAVTPSLLPREKMAAAGALMALTGdLGAMVGPALGGVVIAAG---GVGVAYALAAFTTAVTT--FCITRLPSLPPTHV 205
Cdd:COG0738 116 AANPYVAALGPETAASRLNLLHAFFS-LGALLGPLLGGLLILLGlslSWHLPYLILAVLLLLLAllFLRSKLPEIEEEEE 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 206 ADESPLRSVLSGFRYAsgnRVIGGVLVCGFVTMLLAGWSVLVPEYATEVLGAGPSVVGLLYTAPAVGAVIGSLTSGWTGH 285
Cdd:COG0738 195 EAAGSAASLKSLLKNP---RLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLK 271
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 657824794 286 LRRSGQVVFLLMAVSAAGLVGAGLTATVAVALLGLAAHGFG 326
Cdd:COG0738 272 RFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLG 312
|
|
| PRK06814 |
PRK06814 |
acyl-[ACP]--phospholipid O-acyltransferase; |
13-353 |
7.80e-13 |
|
acyl-[ACP]--phospholipid O-acyltransferase;
Pssm-ID: 235865 [Multi-domain] Cd Length: 1140 Bit Score: 70.38 E-value: 7.80e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 13 PLRTSREFRYIFTARVVSLFGLGFLVVA-VPLQVYRLTGSTAQVAAVSAVLGVTTFAATF-----VGGVLADRYDRRRVI 86
Cdd:PRK06814 6 YLMKSRRFAPLFWTQFFGAFNDNFLKNAlVILILYGLSGALGAYNNALVTLAGAVFILPFfifsaLAGQLADKYDKAKLA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 87 AVARgTAGVAFAVLALNAFLPDpKMWVVYVAAVIDGACGGISATALMAVTPSLLPREKMAAAGALMALTGDLGAMVGPAL 166
Cdd:PRK06814 86 KILK-FAEIGIAALAIYGFHLN-SVPLLFAALFLMGIHSALFGPIKYSILPDHLNKDELLGANALVEAGTFIAILLGTII 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 167 GGVVIAaGGVGVAYALAAFTTAV----TTFCITRLPSLPPTHVADESPLRSVLSGFRYASGNRVI--GGVLVCGFVTMLL 240
Cdd:PRK06814 164 GGLATI-SGNFVILVALLMGIAVlgwlASLFIPKTGNAAPDLKIDRNIIRSTITLLKYAKADKRIwlAILGISWFWLVGA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 241 AGWSVLvPEYATEVLGAGPSVVGLLYTAPAVGAVIGSLTSGWTGHlrrsGQVVFLLMAVSAAGLVGAGLTATVAVA---- 316
Cdd:PRK06814 243 VVLSQL-PLLAKETLGGDENVATLFLAVFSVGVAVGSFLASKLSE----GRITLLYVPIGALLMGLFGLDLAFASSsvpa 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 657824794 317 --------------------LLGLAAHGFGDALTDIVRYATVQKHTPDEYRGRIAAV 353
Cdd:PRK06814 318 epaqlksilvflskrhgwriLIDLFGLAAAGGLYIVPLFAALQAWANPAHRARVIAA 374
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
28-356 |
1.65e-12 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 68.22 E-value: 1.65e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 28 VVSLFGLGFLVVAVPLQVYRLTGSTAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVArgtAGVAFAVLALNAFLP 107
Cdd:cd06174 6 FLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLG---LLLFALGALLFAFAP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 108 DPkmWVVYVAAVIDGACGGISATALMAVTPSLLPREKMAAAGALMALTGDLGAMVGPALGGVVIAAGGVG-----VAYAL 182
Cdd:cd06174 83 SF--WLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGwravfLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 183 AAFTTAVTTFCITRLPSLPPTHVADESPLRSVLSGFRYASGNR-VIGGVLVCGFVTMLLAGWSVLVPEYATEVLGAGPSV 261
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPgLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 262 VGLLYTAPAVGAVIGSLTSGWTGHLRRSGQVVFLL-MAVSAAGLVGAGLTATVAVALLGLAAHGFGDALTDIVRYATVQK 340
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIgLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330
....*....|....*.
gi 657824794 341 HTPDEYRGRIAAVWAA 356
Cdd:cd06174 321 LFPPEIRGTAFGLLNT 336
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
23-354 |
2.40e-11 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 64.90 E-value: 2.40e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 23 IFTARVVSLFGLGFLVVAVPLQVYRLTGSTAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVARGTAGVAfavlAL 102
Cdd:cd17474 4 VFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIG----GL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 103 NAFLPDPKMWVVYVAAVIDGACGGISATALMAVTPSLLPREKMAAAGALMALTGdLGAMVGPALGGVViaaGGVGVAYAL 182
Cdd:cd17474 80 LCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALG-LGIAVGPLLGGLL---AAISWRYPF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 183 AAFTTAVTTFCITRLPSLPPTHVADESPLRSVLSGFRYASGNRVIGGVLVCGFVTM-LLAGWSVLVPEYATEVLGAGPSV 261
Cdd:cd17474 156 FLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFfLYFAFLTYLPFLLELLYGISPII 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 262 VGLLYTAPAVGAVIGSLTSGWTGHLR-RSGQVVFLLMAVSAAGLVGAGLTATVAVALLGLAAHGFGDALTDIVRYATVQK 340
Cdd:cd17474 236 IGLLFAGWSVLLALGSLFVGRLLKKRfGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTE 315
|
330
....*....|....
gi 657824794 341 HTPDEYRGRIAAVW 354
Cdd:cd17474 316 LAPEEERGTASSLY 329
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
51-326 |
5.39e-11 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 63.75 E-value: 5.39e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 51 STAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVARGTAGVAFAVLALNaflpdPKMWVVYVAAVIDGACGGISAT 130
Cdd:COG2223 38 SAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALA-----VSYWLLLLLGLLLGIGGGGSFA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 131 ALMAVTPSLLPREKMAAAGALMALTGDLGAMVGPALGGVVIAAGGVGVAYALAAFTTAVTTFCITRLPSLPPTHVADES- 209
Cdd:COG2223 113 VGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAk 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 210 -PLRSVLSGFRYAsgnRVIGGVLVCGFVTMLLAGWSVLVPEYATEVLGAGPSVVGLLYTAPAVGAVIGSLTSGWTG---H 285
Cdd:COG2223 193 aSLRDQLEALRDP---RFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSdriG 269
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 657824794 286 LRRSGQVVFLLMAVSAAGLVGAGLTATVAVALLGLAAHGFG 326
Cdd:COG2223 270 GRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALG 310
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
14-192 |
2.07e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 61.82 E-value: 2.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 14 LRTSREFRYIFTARVVSLFGLGFLVVAVPLQVYRLTG-STAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVARGT 92
Cdd:cd17325 195 LLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGlSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 93 AGVAFAVLALNAFLpdpkmWVVYVAAVIDGACGGISATALMAVTPSLLPREKMAAAGALMALTGDLGAMVGPALGGVVIA 172
Cdd:cd17325 275 SAVALLLLPLATSF-----WLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD 349
|
170 180
....*....|....*....|
gi 657824794 173 AGGVGVAYALAAFTTAVTTF 192
Cdd:cd17325 350 AFGFATPFLAAAALLLLAAV 369
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
51-408 |
4.66e-10 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 60.65 E-value: 4.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 51 STAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVARGTAGVAFAVLALNaflpdPKMWVVYVAAVIDGACGGISAT 130
Cdd:COG2271 43 SAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFA-----TSFWQLLLLRFLLGLGEAGFFP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 131 ALMAVTPSLLPREKMAAAGALMALTGDLGAMVGPALGGVVIAAGGVGVAYALAAFTTAVTTFCitrlpslppthvadesp 210
Cdd:COG2271 118 AALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL----------------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 211 lrsvlsgfryasgnRVIGGVLVCGFVTMLLAGWSVLVPEYATEVLGAGPSVVGLLYTAPAVGAVIGSLTSGWTG--HLRR 288
Cdd:COG2271 181 --------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSdrLGRR 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 289 SGQVVFLLMAVSAAGLVGAGLTATVAVALLGLAAHGFGDALTDIVRYATVQKHTPDEYRGRIAAVwaaQVTAGASVGAVV 368
Cdd:COG2271 247 RKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGL---VNTFGFLGGALG 323
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 657824794 369 AGAVAALVPISAALPAYGAVGLVITALLWATLRTLRRLDE 408
Cdd:COG2271 324 PLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
51-326 |
1.60e-08 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 56.18 E-value: 1.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 51 STAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVARGTAGVAFAVlalnaFLPDPKMWVVYVAAVIDGACGGISAT 130
Cdd:cd17333 29 NVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALAL-----IFATPSIYLFVVLMFLAGLGAGILDT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 131 ALMAVTPSLLPrEKMAAAGALMALTGDLGAMVGPALGGVVIAAG-GVGVAYALAAFTTAVTTFCI--TRLPSLPPTHVAD 207
Cdd:cd17333 104 GANTFVGALFE-ESSATRLNVLHGFFGLGALIGPLIATSLLTSElSWSWAYLIIGLIYLLLAILIllTLFPELPSARNPQ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 208 ESPLRSVLSGFRYASGNRVIGGVLVCGFVTMLLAGWSVLVPEYATEVLGAGPSVVGLLYTAPAVGAVIGSLTSGWTGHLR 287
Cdd:cd17333 183 QSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRI 262
|
250 260 270
....*....|....*....|....*....|....*....
gi 657824794 288 RSGQVVFLLMAVSAAGLVGAGLTATVAVALLGLAAHGFG 326
Cdd:cd17333 263 KPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLF 301
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
23-353 |
5.07e-07 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 51.42 E-value: 5.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 23 IFTARVVSLFGLGFLVVAVPLQVYRLTGSTA---QVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVARGTAGVAFAV 99
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGAsgyYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 100 LALNAFLpdpkmWVVYVAAVIDGACGGISATALMAVTPSLLPREKMAAAGALMALTGdLGAMVGPALGGVVIAAGGVGV- 178
Cdd:cd17330 81 LGLSRNL-----WLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFG-LGFILGPALGGFLSTPYGYALp 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 179 AYALAAFTTAVTTFCITRLPSLPPTHvadesplrsvlsgfryasgnrviggvLVCGFVTMLLAGWSVLVPEYATEVLGAG 258
Cdd:cd17330 155 FLVAAALALLNLVLVLFFLPPLRRLL--------------------------LVYFLIALAFAGLESVFSLFLKDRFGFS 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 259 PSVVGLLYTAPAVGAVIGSLtsGWTGHLRRSG---QVVFLLMAVSAAGLVGAGLTATVAVALLGLAAHGFGDALTDIVRY 335
Cdd:cd17330 209 PSQIGLLLALVGIAGILAQL--LLIPRLAKRLgerKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALS 286
|
330
....*....|....*...
gi 657824794 336 ATVQKHTPDEYRGRIAAV 353
Cdd:cd17330 287 ALLSKSVPSKEQGKAQGI 304
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
51-198 |
9.22e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 50.28 E-value: 9.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 51 STAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVARGTAGVAFAVLALNAFLPdpkmWVVYVAAVIDGACGGISAT 130
Cdd:cd17365 204 SLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASL----VLLYVLVFLAGACVNGAQV 279
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 657824794 131 ALMAVTPSLLPREKMAAAGALMALTGDLGAMVGPALGGVVIAAG----GVGVAYALAAFTTAVTTFCITRLP 198
Cdd:cd17365 280 GLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGlgpeSVFLALAIPAALGALAVLLLRLRR 351
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
56-338 |
1.13e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 50.29 E-value: 1.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 56 AAVSAVLGVTTFAATFV---GGVLADRYD-----RRRVIAVARGTAGVAFAVLALN-AFLPDPKMWVVYVAAVIDGACGG 126
Cdd:COG2211 46 ALVGLILLVARLWDAITdplIGALSDRTRtrwgrRRPWILIGAIPLALSFVLLFTApDLSPTGKLIYALVTYLLLGLAYT 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 127 ISATALMAVTPSLLPREKMAAAGALMALTGD-LGAMVGPALGGVVIAAGG---------VGVAYALAAFTTAVTTFCITR 196
Cdd:COG2211 126 LVNIPYSALGAELTPDYEERTRLSSWRFAFAgLGGLLASVLPPPLVAAFGgdaalgyrlTALIFAVLGLLAFLLTFFGTK 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 197 lpslppTHVADESPLRSVLSGFRYASGNRVIGGVLVCGFVTML-LAGWSVLVPEYATEVLGAGPSVVGLLYTAPAVGAVI 275
Cdd:COG2211 206 ------ERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLaLALVAALLLYYFKYVLGLSAALVGLLLALYFLAALL 279
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 657824794 276 GSLTSGWTGHLRRSGQVVFLLMAVSAAGLVGAGL--TATVAVALLGLAAHGFGDALTDIVRYATV 338
Cdd:COG2211 280 GAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFlgPGNLWLLLVLAALAGIGLGAILVLPWAML 344
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
33-352 |
1.26e-06 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 50.69 E-value: 1.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 33 GLGFLVVAVPLQVYRLTGSTAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVARgTAGVAFAVLALNAFLPDPkMW 112
Cdd:PRK08633 27 GHKILIQNTLIKAYDGSEQVILTAIVNALFLLPFLLLSSPAGFLADKFSKNRVIRIVK-LFEVGLTLLIVLAYYLGW-FW 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 113 VVYVAAVIDGACGGISATALMAVTPSLLPREKMAAAGALMALTGDLGAMVGPALGGVVIAAGGVG-----------VAYA 181
Cdd:PRK08633 105 LAFAVTFLLGAQSAIYSPAKYGIIPELVGKENLSRANGLLEAFTIVAILAGTALFSFLFESVNGNtpseilgriapAGLV 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 182 LAAFtTAVTTFCITRLPSLPPTHVADES-----PLRSVLSGFRYASGNRVIG----GVLVCGFVTMLLagwSVLVPEYAT 252
Cdd:PRK08633 185 LLAV-AVLGLIFAYRLPKVPAAAPEVFDkkkylFPKLLWRNLKLLRSDRVLWlaiiGLSYFWFISQLA---QANFPAYAK 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 253 EVLGAGPS-VVGLLYTAPAVGAVIGSLTSGwtghlRRSGQVV-FLLMAVSAAGLVGAGLTA----TVAVALLGLAAHGFG 326
Cdd:PRK08633 261 EVLGLDNTfQVQYLLAASAIGIGIGSLLAG-----RLSGRHIeLGLVPLGALGLALSLFLLptapSLASVLVLFFLFGFS 335
|
330 340
....*....|....*....|....*.
gi 657824794 327 DALTDIVRYATVQKHTPDEYRGRIAA 352
Cdd:PRK08633 336 AGLFIVPLNALIQFRAPEKELGKVLA 361
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
14-175 |
1.80e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 49.90 E-value: 1.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 14 LRTSREFRYIFTARVVSLFGLG-FLVVAVPLQVYRLTGSTAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVARGT 92
Cdd:COG2211 224 LLKNRPFLLLLLAYLLFFLALAlVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLL 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 93 AGVAFAVLalnAFLPDPKMWVVYVAAVIDGACGGISATALMAVTPSLLPREKMAAAGALM-------ALTGDLGAMVGPA 165
Cdd:COG2211 304 AALGLLLL---FFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRREglyfgifTFAIKLGQALAGA 380
|
170
....*....|
gi 657824794 166 LGGVVIAAGG 175
Cdd:COG2211 381 LAGLLLALFG 390
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
72-355 |
2.45e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 49.11 E-value: 2.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 72 VGGVLADRYDRRRVIAVARgtagVAFAVLALNAFLPDPKMWVVYVAAVIDGACGGI--SATALMAVTPSLLPREKMAAAG 149
Cdd:cd17473 54 LAGWLADRFGRKRLLIAGL----LLYGIGGVAGLFLDSLYALLASRALLGIGVAGImtLATALIGDYFEGEERAKMLGLQ 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 150 ALMALtgdLGAMVGPALGGVVIAAG--GVGVAYALAAFTTAVTTFCITRLPSLPPTHVADESPLRSVLSgfryasgNRVI 227
Cdd:cd17473 130 SAAMS---LGGVVFLLLGGALAEIGwrAPFLVYLLALPVLILVLLFLPEPARKSKSAASPGAATAAALP-------WKRV 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 228 GGVLVCGFVTMLLAgWSVLV--PEYATEVLGAGPSVVGLLYTAPAVGAVIGSLTSGWTGHLRRSGQVVFLLMAVSAAGLV 305
Cdd:cd17473 200 LPIYFLAFLAMLLF-YVIPIqlPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFL 278
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 657824794 306 GAGLTATVAVALLGLAAHGFGDALTDIVRYATVQKHTPDEYRGRIAAVWA 355
Cdd:cd17473 279 LLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVT 328
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
51-322 |
5.12e-06 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 48.34 E-value: 5.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 51 STAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVARGTAGVAFAVLALNaflpdPKMWVVYVAAVIDGACGGISAT 130
Cdd:cd17320 32 SASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALA-----SSIEQLLIARFLQGLGAAAGSV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 131 ALMAVTPSLLPREKMAAAGALMALTGDLGAMVGPALGGVVIAAGG-VGVAYALAAFTTAVTTFCITRLPSLPPTHVAdES 209
Cdd:cd17320 107 VARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGwRAIFVFLALLGLLLLLLVLLFLPETLPEEKR-KP 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 210 PLRSVLSGFRYASGNR-VIGGVLVCGFVTMLLAGWSVLVPEYATEVLGAGPSVVGLLYTAPAVGAVIGSLTSGWTghLRR 288
Cdd:cd17320 186 LLSSLLRAYKRVLKNRrFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRL--VRR 263
|
250 260 270
....*....|....*....|....*....|....
gi 657824794 289 SGQVVFLLMAVSAAGLVGAGLTATVAVALLGLAA 322
Cdd:cd17320 264 FGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWP 297
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
33-326 |
8.45e-06 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 47.63 E-value: 8.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 33 GLGFLVVAVPLQVYRLTGSTAQVAAVSAVL----GVTTFAATFVGGVLADRYDRRRVIAVARGTAGVAFAVLALNaflpd 108
Cdd:cd17388 14 GIGLIMPVLPTLLREFVGDSADAATHYGVLlalyALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFA----- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 109 PKMWVVYVAAVIDGACGGISATAlMAVTPSLLPREKMAAAGALMALTGDLGAMVGPALGGVviaAGGVGV-----AYALA 183
Cdd:cd17388 89 PTLWWLYLGRIIAGITGATGAVA-AAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGL---LGEISPrapflVAAGL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 184 AFTTAVTTFCITRlPSLPPTHVADESPLR-SVLSGFRYASGNRVIGGVLVCGFVTMLLAG-----WSVLVPE---YATEV 254
Cdd:cd17388 165 NGLNFLLGLFVLP-ESLPPERRRAFRWRRaNPFGSLRWLTGFPGLLGLLAVFFLIQLIGQvpattWVLFTEDrfdWSPTM 243
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 657824794 255 LGAGPSVVGLLYtAPAVGAVIGSLTSGWtGHLRrsgqVVFLLMAVSAAGLVGAGLTATVAVALLGLAAHGFG 326
Cdd:cd17388 244 VGLSLAVFGLLH-ALFQAFVTGPIAKRL-GEKR----AILLGLAADALGFLLLAFATQGWMVFPILILLALG 309
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
35-322 |
1.59e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 46.78 E-value: 1.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 35 GFLVVAVPLQVYRLTGSTAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVARGTAGVAFAVLALNAFLpdpkmWVV 114
Cdd:cd17478 13 GFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNY-----WLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 115 YVAAVIdgacGGISATA---LMAVTPSLLPREKMAAAGALMALTGDLGAMVGPALGGVVIAAGGVGVAYALAAFTTAVTT 191
Cdd:cd17478 88 LLLVAL----AGIGSAAfhpEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 192 FCITRLPSLPPTHVADESPLRSVLSGFRYASGNrVIGGVLVCGFVTMLLAGWSVLVPEYATEVlGAGPSVVGLLYTAPAV 271
Cdd:cd17478 164 LLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRA-LLLLLIIVFLRSWVLSSLTTFLPFYLVQR-GYSLVFAGLLLSLFLF 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 657824794 272 GAVIGSLTSGWTGHLRRSGQVVFLLMAVSAAGLVGAGLTATVAVALLGLAA 322
Cdd:cd17478 242 AGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLA 292
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
74-326 |
1.81e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 46.39 E-value: 1.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 74 GVLADRYDRRRVIAVARGTAGVAFAVLALNaflpdPKMWVVYVAAVIDGACGGISATALMAVTPSLLPREKMAAAGALMA 153
Cdd:cd17324 55 GPLSDRIERRRLLLVLLLLFILGNLLAALA-----PSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVF 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 154 LTGDLGAMVGPALGGVVIAAGGVGVAYALAAFTTAVTTFCITR-LPSLPPTHVADESPLRSVLSGFRyasgNRVIGGVLV 232
Cdd:cd17324 130 SGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRlLPSLPPKKPGSLGLLSSLLLLLR----NPRLRLAYL 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 233 CGFVTM--LLAGWSVLVPeYATEVLGAGPSVVGLLYTAPAVGAVIGSLTSGWTGHLRRSGQVVFLLMAVSAAGLVGAGLT 310
Cdd:cd17324 206 ITFLLFggFFALYTYLAP-FLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLG 284
|
250
....*....|....*.
gi 657824794 311 ATVAVALLGLAAHGFG 326
Cdd:cd17324 285 PSPLLLLVGLVLWGLG 300
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
32-326 |
2.17e-05 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 46.10 E-value: 2.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 32 FGLGFLVVAVPLQVYRLTGSTAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVARGTAGVAFAVLALNaflpdPKM 111
Cdd:cd17393 13 ILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLA-----PSV 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 112 WVVYVAAVIDGACGGISATAlMAVTPSLLPREKMAAAGALMALTGDLGAMVGPALGGVVIAAGGVGVAYALAAFTTAVTT 191
Cdd:cd17393 88 PALALALFLFGAANGALDVA-MNAQGVAVERAYGRPIMSSLHAMWSLGGLAGALLGAAAIGAGVSPGVHLLAAAVLLLLA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 192 FCITRLPSLPPTHVADESPLRSVLSGFRYASGNRVIGGVLVCgFVTMLLAG----WSVLvpeYATEVLGAGPSVVGLLYT 267
Cdd:cd17393 167 ALVAIRALLPGTGEAAEDRPDGAGKPGFLLPNRLLLLLGLLA-LAAALAEGaaadWSAL---YLRDVLGASAALAALGYA 242
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 657824794 268 APAVGAVIGSLTSGWTGHLRRSGQVVFLLMAVSAAGLVGAGLTATVAVALLGLAAHGFG 326
Cdd:cd17393 243 VFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLG 301
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
26-304 |
2.72e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 45.57 E-value: 2.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 26 ARVVSLFGLGFLVVAVPLQVYRLTGSTAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVARGTAGVAFAVLALNaf 105
Cdd:COG0477 22 GTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLA-- 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 106 lpdPKMWVVYVAAVIDGACGGISATALMAVTPSLLPREKMAAAGALMALTGDLGAMVGPALGGVVIAAGGVGVAYALAAF 185
Cdd:COG0477 100 ---PSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 186 TTAVTTFCITRLPSLPPTHVADESPLRSVLSGFRYASGNRVIGGVLVCGFVTMLLAGWSVLVPEYATEVLGAGPSVVGLL 265
Cdd:COG0477 177 LGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLAL 256
|
250 260 270
....*....|....*....|....*....|....*....
gi 657824794 266 YTAPAVGAVIGSLTSGWTGHLRRSGQVVFLLMAVSAAGL 304
Cdd:COG0477 257 LLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
23-192 |
3.90e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 45.24 E-value: 3.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 23 IFTARVVSLFGLGFLVVAVPLQVYRLTGSTAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVARGTAGVAFAVLAL 102
Cdd:cd17477 193 ALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPL 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 103 NAFLPdpkmWVVYVAAVIDGACGGISATALMAVTPSLLPREKMAAAGALMALTGDLGAMVGPALGGVVIAA-GGVGVAYA 181
Cdd:cd17477 273 VPGLP----LALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAfGPHGLFLF 348
|
170
....*....|.
gi 657824794 182 LAAFTTAVTTF 192
Cdd:cd17477 349 LAAVALLFLLF 359
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
51-353 |
4.02e-05 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 45.25 E-value: 4.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 51 STAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVARGTAGVAfavLALNAFLPDPKMWvvYVAAVIDGACGGISAT 130
Cdd:cd17319 36 SPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF---TALTGFATSLTSL--YVLRFLLGVAEAGFFP 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 131 ALMAVTPSLLPREKMAAAGALMALTGDLGAMVGPALGGVVIAAGGVGVAyalaafttavttFCITRLPSLppthvadesp 210
Cdd:cd17319 111 GAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWA------------FIIEGLLGL---------- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 211 lrsVLSGFRYASGNRVIGGVLVCGFVTMLLAGWSVLVPEYATEVLGAGPSVVGLLYTAPAVGAVIGSLTSGW---TGHLR 287
Cdd:cd17319 169 ---LLAVLWWFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRlsdRLLRG 245
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 657824794 288 RSGQVVFLLMAVSAAGLVGAGLTATVAVALLGLAAHGFGDALTDIVRYATVQKHTPDEYRGRIAAV 353
Cdd:cd17319 246 ARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGL 311
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
51-322 |
7.13e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 44.57 E-value: 7.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 51 STAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVARGTAGVAFAVLalnAFLPDPKMWVVYVAAVIDGACGGISAT 130
Cdd:cd17355 36 SRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLL---ALATSLWQLYLLWGLLGGGGAGTLAAV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 131 ALMAVTPSLLPREKMAAAGALMALTGdLGAMVGPALGGVVIAAGG-----VGVAYALAAFTTAVTTFCITRLPSLPPTHV 205
Cdd:cd17355 113 AFATVAAWWFERRRGLALGILTAGGG-LGSLVFLPLGAALIEAFGwrtalLVLALLALLVLVPVLLLLRRRPADLALRAY 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 206 AD---ESPLRSVLSGFRYASGNRVIGGVLVCGFVTMllaGWSVLVPEYATEvLGAGPSVVGLLYTAPAVGAVIGSLTSGW 282
Cdd:cd17355 192 DDaspASPGSTLKEALRSASFWLLALAFFLCGFAVV---GLIVHLVPYLAD-RGISPAAAAVALALIGLFNIVGRLLSGW 267
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 657824794 283 TGHLRRSGQVVFLLMAVSAAGLVGAGLTATVAVALLGLAA 322
Cdd:cd17355 268 LGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAA 307
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
35-195 |
8.18e-05 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 44.41 E-value: 8.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 35 GFLVVAVPLQVYRLTGSTAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVArGTAGVAFAVLALnAFLP---DPKM 111
Cdd:cd17337 226 GFPVFMPLYFTDTGGFSTSQWLQIWGIIFLVNIFFNLIFGILGDKIGWRRTVRWF-GGVGCAISTLLF-YYVPqlfGHNY 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 112 WVVYVAAVIDGAcgGISA-TALMAVTPSLLPREKMAAAGALMALTGdLGAMVGPALGGVVI-AAGGVGVAYALAA--FTT 187
Cdd:cd17337 304 WAALIAAILFGI--GLAGfVPLSALMPSLAPEHKGAAMSILNLGAG-LSNFVGPAIVTLFLgSFGAGGVVWIFAGlyLLS 380
|
....*...
gi 657824794 188 AVTTFCIT 195
Cdd:cd17337 381 AVLTLFLK 388
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
230-416 |
1.03e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.19 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 230 VLVCGFVTMLLAGWSVLVPEYATEvLGAGPSVVGLLYTAPAVGAVIGSLTSGWTGHLRRSGQVVFLLMAVSAAGLVGAGL 309
Cdd:COG2814 16 ALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 310 TATVAVALLGLAAHGFGDALTDIVRYATVQKHTPDEYRGRIAAVWAAQVTAGASVGAVVAGAVAALVPISAALPAYGAVG 389
Cdd:COG2814 95 APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLA 174
|
170 180
....*....|....*....|....*..
gi 657824794 390 LVITALLWATLRTLRRLDEGTSLERVA 416
Cdd:COG2814 175 LLALLLLLRLLPESRPAARARLRGSLR 201
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
48-282 |
2.16e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 42.98 E-value: 2.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 48 LTGSTAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVArgtaGVAFAVLA--LNAFLPDPkmWVVYVAAVIDGACG 125
Cdd:cd17490 26 LGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIII----GLLFTVLAslIMILFPSP--WGLLIARFLSGIAA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 126 G--ISATALMAvtpSLLPREKMAAAGALMALTGDLGAMVGPALGGVVIAAGGVGVAYALAAFTTAVTTFCITRLPSLPPT 203
Cdd:cd17490 100 AtwVSFTVLYA---SYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERRE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 204 HVADESPLRSVLSGFRYAsgnRVIGGVLVCGFVTMLL-AGWSVLVPEYATEvLGAGPSVVGLLYTAPAVGAVIGSLTSGW 282
Cdd:cd17490 177 KKPVLTELKELLSVLKDK---KLLFFSLLAILQQMITfSTTFGFTPLIAKQ-LGASSFQLGLLSIIYLLPNALASLLSGT 252
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-164 |
3.45e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.41 E-value: 3.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 17 SREFRYIFTARVVSLFGLGFLVVAVPLQVYRLTGSTAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVARGTAGVA 96
Cdd:pfam07690 199 RDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILA 278
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 657824794 97 FAVLALnaFLPDPKMWVVYVAAVIDGACGGISATALMAVTPSLLPREKMAAAGALMALTGDLGAMVGP 164
Cdd:pfam07690 279 ALGLLL--LSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
28-189 |
3.60e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 42.53 E-value: 3.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 28 VVSLFGLGFLVVAVP-LQVYRLTGSTAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVargtaGVAFAVLALNAFL 106
Cdd:cd17370 208 AVALFALGNFSFAFLiLRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLIL-----GYLSLALAYLGFA 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 107 PDPKMWVVYVAAVIDGACGGISATALMAVTPSLLPREKMAAAGALMALTGDLGAMVGPALGGVVIAAGGVGVAYALAAFT 186
Cdd:cd17370 283 LGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVL 362
|
...
gi 657824794 187 TAV 189
Cdd:cd17370 363 ALI 365
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
51-322 |
4.16e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 42.17 E-value: 4.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 51 STAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVARGTAGVAFAVLALnaflpDPKMWVVYVAAVIDGACGGISAT 130
Cdd:COG2807 51 SATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSL-----APSVALLLAGTALIGAGIAVGNV 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 131 ALMAVTPSLLPReKMAAAGALMALTGDLGAMVGPALGGVVIAAGGVGVAYALAAFTTAVTTFCITRLPSLPPTHVADESP 210
Cdd:COG2807 126 LLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPA 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 211 LRSVLSGFRYASGNRVIGGVLVCGFVTMLLAGWsvlVPEYATEvLGAGPSVVGLLYTAPAVGAVIGSLTSGW-TGHLRRS 289
Cdd:COG2807 205 AASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAW---LPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLlADRLGDR 280
|
250 260 270
....*....|....*....|....*....|....*..
gi 657824794 290 GQVVFLLMAVSAAGLVGAGLT----ATVAVALLGLAA 322
Cdd:COG2807 281 RPLLLLLGLLGLAGLLGLLLApgslPWLWAVLLGLGQ 317
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
51-185 |
4.53e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 42.17 E-value: 4.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 51 STAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVARGTAGVAFAVLALNAFLPDPkmWVVYVAAVIDGACGGISAT 130
Cdd:cd17319 213 SLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSP--VVAVILLSLAGFGIGAASP 290
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 657824794 131 ALMAVTPSLLPREKMAAAGALMALTGDLGAMVGPALGGVVIAAGG--------VGVAYALAAF 185
Cdd:cd17319 291 VFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGsytaaflfLAAVALLAAL 353
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
17-174 |
5.10e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 41.77 E-value: 5.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 17 SREFRYIFTARVVSLFGLGFLVVAVPLQVYRLTGSTAQVAAVS-AVLGVTTFAATFVGGVLADRYDRRRVIAVarGTAGV 95
Cdd:cd17321 167 ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLAlLPLALAMLVAAPLAGRLADRFGPRLVLVA--GLLLT 244
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 657824794 96 AFAVLALNAFLPDPKMWVVYVAAVIDGACGGISATALMAVTPSLLPREKMAAAGALMALTGDLGAMVGPALGGVVIAAG 174
Cdd:cd17321 245 AVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAG 323
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
23-322 |
5.76e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.78 E-value: 5.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 23 IFTARVVSLFGLGFLVVAVPLQVYRLTGSTAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVArgtAGVAFAVLAL 102
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAG---AAITAVSVLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 103 NAFLPDPKMWVVYVAAvidgacGGISATALMAVTPSLL----PREKMAAAGALMALTGDLGAMVGPALGGVVIAAGGVGV 178
Cdd:cd17477 78 LALTDSPWVWFLLRFV------MGIGLAGLFVVSESWLnalaTNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPF 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 179 AYALAAFTTAVTTFCITRLPSlPPTHVADESPLRSVLSgfryasgnRVIGGVLVCGFVTMLLAGWSVLVPEYATEvLGAG 258
Cdd:cd17477 152 LIAAVLLLLALVPLLLTRRAA-PEIEEAESISLRRLLR--------IAPLALLGAFVAGFLEGAFYSLLPLYGLR-LGLS 221
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 657824794 259 PSVVGLLYTAPAVGAVIGSLTSGWTGHLRRSGQVVFLLMAVSAAGLVGAGLTATVAVALLGLAA 322
Cdd:cd17477 222 VAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLF 285
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
14-143 |
7.04e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 41.50 E-value: 7.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 14 LRTSREFRYIFTARVVSLFGLGFLVVAVPLQVYRLTG-STAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVARGT 92
Cdd:COG2814 203 LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGlSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLL 282
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 657824794 93 AGVAFAVLALNAFLpdpkmWVVYVAAVIDGACGGISATALMAVTPSLLPRE 143
Cdd:COG2814 283 LALGLLLLALAGSL-----WLLLLALFLLGFGFGLLFPLLQALVAELAPPE 328
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
51-192 |
8.12e-04 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 41.44 E-value: 8.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 51 STAQVAAVSAVLG-VTTFAATFVGGVLADRYDRRRVIAVARGTAGVAFAVLALNAF-LPDPKMWVVYVAAVIDGACGGIS 128
Cdd:cd17485 240 SLSQIGLLSGVGGsLVSIAGSLLGGYLLKRRGRRRLLLLGGLLRLLLLGLYTLLALgGSGLNWVLLLASLALLHLVGGMI 319
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 657824794 129 ATALMAVTPSLLPREKMAAAGALMALTGDLGAMVGPALGGVVIAAGGVGVAYALAAFTTAVTTF 192
Cdd:cd17485 320 TTALFTLMMDCSQQAQAGTDYTLLATVEVLGKLLFGSLAGFLADHLGYAAAFLLFAILSALSVL 383
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
244-397 |
9.54e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.86 E-value: 9.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 244 SVLVPEYATEVLGAGPSVVGLLYTAPAVGAVIGSLTSGWTGHLRRSGQVVFLLMAVSAAGLVGAGLTATVAVALLGLAAH 323
Cdd:pfam07690 16 GPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQ 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 657824794 324 GFGDALTDIVRYATVQKHTPDEYRGRIAAVWAAQVTAGASVGAVVAGAVAALVPISAALPAYGAVGLVITALLW 397
Cdd:pfam07690 96 GLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLL 169
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
32-396 |
1.14e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 40.66 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 32 FGLGFLVVAVPLQVYRLTGSTAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVARGTAGVAfavLALNAFLPDPkm 111
Cdd:cd17316 15 FFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLA---TLLIGLLPTP-- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 112 WVVYVAAVIDGACGGISATALMAVTPSLLPREKMAAAGALMALTGDLGAMVGPALGGVVIAAGGVGVAYALAAFTTAVTT 191
Cdd:cd17316 90 ILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALPA 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 192 FCITrlpslppthvadesPLRsvlsgfryasgNRVIGGVLVCGFVTMLLAGWSVLVPEYATEVLGAGPSVVGLLYTAPAV 271
Cdd:cd17316 170 LLAL--------------LLR-----------RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 272 GAVIGSLTSGWTGHL--RRSGQVVFLLMAVSAAGLVGAGLTATVAVALLGLAAHGFGDALTDIVRYATVQKHTPDEYRGR 349
Cdd:cd17316 225 GALVGALIAGLLSDRigRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRAT 304
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 657824794 350 iAAVWAAQVTAGASVGAVVAGAVAALVPISAALPAYGAVGLVITALL 396
Cdd:cd17316 305 -GVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALI 350
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
231-353 |
1.55e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 40.24 E-value: 1.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 231 LVCGFVTMLLAGWSVLVPEYATEVLGAGPSVVGLLYTAPAVGAVIGSLTSGW----TGHLRRSGQVVFLLMAVSAAGLVG 306
Cdd:cd17502 174 IFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGAliskTGRYKPLIVIGTILMSVGAGLLTT 253
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 657824794 307 AGLTATVAVALLGLAAHGFGDALTDIVRYATVQKHTPDEYRGRIAAV 353
Cdd:cd17502 254 LTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATAT 300
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
33-350 |
1.67e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 40.33 E-value: 1.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 33 GLGFLVVA--VPLQVYRLTGSTAQVAAVSA--VLGVTTFAATFV---GGVLADRYDRRrvIAVARGTAGVAFAVLALnAF 105
Cdd:cd17391 9 GIGFSLIApfLPLYIEQLGVTSGGLVELWSglAFSSTFLVSAIFspiWGRLADRYGRK--PMLLRASLGMAIVIGLM-AF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 106 LPDpkMWVVYVAAVIDGACGGIS--ATALMAvtpSLLPREKMAAAGALMALTGDLGAMVGPALGGVVIAAGGVGVAYALA 183
Cdd:cd17391 86 VTN--VWQLLILRLLQGVFSGYVpnATALIA---SQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFIT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 184 AF----TTAVTTFCITRlpSLPPTHVADESPLRSVLSGFRYASgnrVIGGVLVCGFVTmLLAGWSV--LVPEYATEVLGA 257
Cdd:cd17391 161 GGllflAFLLTLFFVKE--DFKPVEKKKMVSTKEVWNSVPNPS---LLISLFVTTFII-QLANQSIepILTLYIRQLMGD 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 258 GPSVV---GLLYTAPAVGAVIgslTSGWTGHL--RRSGQVVFLLMAVSAAGLVGAGLTATVAVALLGL-AAHGFGDALTD 331
Cdd:cd17391 235 ASNLAfisGLVFSATGVSSLL---SAPRLGKLgdRIGHHRILLGALLASALLYIPQAFVQTPWQLGILrFLLGLATGGLL 311
|
330
....*....|....*....
gi 657824794 332 IVRYATVQKHTPDEYRGRI 350
Cdd:cd17391 312 PAINSLLAKITPKEVAGRI 330
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
23-330 |
2.10e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.85 E-value: 2.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 23 IFTARVVSLFGLGFLVVAVPLQVYRLTGSTAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVARGTAGVAFAVLAL 102
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 103 NaflpdPKMWVVYVAAVIDGACGGISATALMAVTPSLLPREKMAAAGALMALTGDLGAMVGPALGGVVIAAGGVGVAYAL 182
Cdd:cd17321 81 A-----PSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 183 AAFTTAVTTFCitrlpslppthvadesplrsvlsgfryasGNRVIGGVLVCGFVTMLLAGWSVLVPEYATEVLGAGPSVV 262
Cdd:cd17321 156 NVPIGLVALLL-----------------------------ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQA 206
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 657824794 263 GLLYTAPAVGAVIGSLTSGWTGHLRRSGQVV---FLLMAVSAAGLVGAGLTATVAVALLGLAAHGFGDALT 330
Cdd:cd17321 207 GLALLPLALAMLVAAPLAGRLADRFGPRLVLvagLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLF 277
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
158-402 |
2.17e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 39.89 E-value: 2.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 158 LGAMVGPALGGVVIAAGGVGVAYALAAF----TTAVTTFCITRLPSLPPTHVADESPLRSVLSGFRYASGNRVIGGV--- 230
Cdd:cd17331 133 IGMVVGSFLGGLLTKKFGEQAAALVAAVgsllSIVLVILLIPSNTKSKREKEAKESASPPSVFNLKEILRLLRLPGVafl 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 231 -LVCGFVTMLLAGWSVLVPEYATEVLGAGPSVVGLLYTAPAV-GAVIGSLTSGWTGHLRRSGQVVFLLMAVSAAGLVGAG 308
Cdd:cd17331 213 lLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVlGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLA 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 309 LTATVAVALLGLAAHGFGDALTDIVRYATVQKHTPDEYRGRIAAVWAAqvtaGASVGAVVAGAVAALVPISAALPAYGAV 388
Cdd:cd17331 293 FVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHA----LFSLVRTVSPTIGGALLQAYGFPSFGLL 368
|
250
....*....|....
gi 657824794 389 GLVITALLWATLRT 402
Cdd:cd17331 369 GAAINGLLTVYLLL 382
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
224-348 |
3.17e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 39.53 E-value: 3.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 224 NRVIGGVLVCGFVT-MLLAGWSVLVPEYATEVLGAGPSVVGLLYTAPAVGAVIGSLTSGW----TGHLRRSGQVVFLLMA 298
Cdd:cd06179 261 GRNFALILIVAFVEgMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILAGLlltkIKHIKWQLVAGFVLFT 340
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 657824794 299 VSAAGLVGAGLTAT-VAVALLGLAAHGFGDALTdiVRYATVQKHTPDEYRG 348
Cdd:cd06179 341 AFLALLALITPDNKaLAIAFSVLAGIGIGGPLV--LAIVIVQLSVPPEDIG 389
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
50-195 |
6.18e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 38.68 E-value: 6.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 50 GSTAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVARGTAGVAFAVLALNaflpdPKMWVVYVAAVIDGACGGISA 129
Cdd:cd17324 231 FSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLG-----PSPLLLLVGLVLWGLGFFAAH 305
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 657824794 130 TALMAVTPSLLPREKmAAAGALMALTGDLGAMVGPALGGVVIAAGGVGVAYALAAFTTAVTTFCIT 195
Cdd:cd17324 306 SALQTRVLRLAPEAR-GLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
28-171 |
6.36e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 38.49 E-value: 6.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 28 VVSLFGLGFLVVAVPLQVYRLTGSTAQVAAVSAVLGVTTFAATFVGGVLADRYdRRRVIAVARGTAGVAFAVLALNAFLP 107
Cdd:TIGR00895 260 FMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRL-GPRVTALLLLLGAVFAVLVGSTLFSP 338
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 657824794 108 DpkmwVVYVAAVIDGACGGISATALMAVTPSLLPREKMAAAGALMALTGDLGAMVGPALGGVVI 171
Cdd:TIGR00895 339 T----LLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYLL 398
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
226-356 |
9.24e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 37.93 E-value: 9.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 226 VIGGVLVCGFVTMLLAGWSVLVPEYATEvLGAGPSVVGLLYTAPAVGAVIGSLTSGWTGHLRRSGQVVFLLMAVSAAGLV 305
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAAPPLQAD-LGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL 90
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 657824794 306 GAGLTATVAVALLGLAAHGFGDALTDIVRYATVQKHTPDEYRGRIAAVWAA 356
Cdd:COG2271 91 LFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNA 141
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
38-309 |
9.57e-03 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 37.96 E-value: 9.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 38 VVAVPLQVYRLTGSTAQVAAVSAVLGVTTFAATFVGGVLADRYDRRRVIAVARGTAGVAfAVLALNAflpdPKMWVVYVA 117
Cdd:PRK11652 28 VPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILG-TLVALFA----HSLTVLIAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 118 AVIDGAcgGISATALMAVTpslLPREkmAAAGALMALTGDLGAM-------VGPALGGVVIAAGGVGVAYA-LAAFTTAV 189
Cdd:PRK11652 103 SAIQGL--GTGVGGVMART---LPRD--LYEGTQLRHANSLLNMgilvsplLAPLIGGLLTTLFGWRACYLfLLLLGAGV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657824794 190 TTFCITRLPSLPPThvadESPLRSVLSGFRYASGNRVIGGVLVCgfvtmLLAGWS-VLVPEYAT-----EVLGAGPSVVG 263
Cdd:PRK11652 176 TFSMARWMPETRPA----DARRTRVLASYRTLLSNRRFNCYLLM-----LIGTLAgIAVFEACSgvlmgAVLGLSSMTVS 246
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 657824794 264 LLYTAPAVGAVIGSLTSGwtghlrRSGQVVFLLMAVSAAGLVGAGL 309
Cdd:PRK11652 247 ILFILPIPAAFFGAWFAG------RPNKRFSTLMWQSVICCLLAGL 286
|
|
| |
