|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10906 |
PRK10906 |
DeoR/GlpR family transcriptional regulator; |
1-252 |
1.53e-132 |
|
DeoR/GlpR family transcriptional regulator;
Pssm-ID: 182827 [Multi-domain] Cd Length: 252 Bit Score: 374.58 E-value: 1.53e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 1 MKQIPRHQQIVDLVKTQGYVSTEELVEKFDVSPQTIRRDLNELADNNKIRRYHGGATIPLSSENTSYSTRKALNFNEKDV 80
Cdd:PRK10906 1 MKQTQRHDAIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNDLAEQNKILRHHGGAALPSSSVNTPWHDRKATQTEEKER 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 81 IADQLVKHIPDGATLFVDIGTTPESVARALnKNHKQLRVVTNNINVASILLSNPEIKVILAGGEVRNRDGGIVGEATLDF 160
Cdd:PRK10906 81 IARKVASQIPNGATLFIDIGTTPEAVAHAL-LNHSNLRIVTNNLNVANTLMAKEDFRIILAGGELRSRDGGIIGEATLDF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 161 VKQFRLDFGILGISGIDFDGSLLDFDYHEVRVKQAIIDNSRSILLAVDHSKFGRNAMVKLGNISQAHMVFTNKQPPEEIT 240
Cdd:PRK10906 160 ISQFRLDFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDQLPPASVM 239
|
250
....*....|..
gi 657925904 241 NILKDFSIPLEV 252
Cdd:PRK10906 240 QVIEDHHVQLEL 251
|
|
| GlpR |
COG1349 |
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ... |
1-252 |
2.25e-103 |
|
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];
Pssm-ID: 440960 [Multi-domain] Cd Length: 254 Bit Score: 300.51 E-value: 2.25e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 1 MKQIPRHQQIVDLVKTQGYVSTEELVEKFDVSPQTIRRDLNELADNNKIRRYHGGAT-IPLSSENTSYSTRKALNFNEKD 79
Cdd:COG1349 1 MLAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVlVSSAAAEPPFAERETLNAEEKR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 80 VIADQLVKHIPDGATLFVDIGTTPESVARALnKNHKQLRVVTNNINVASILLSNPEIKVILAGGEVRNRDGGIVGEATLD 159
Cdd:COG1349 81 AIARAAASLIEDGDTIFLDAGTTTLALARAL-PDRRNLTVVTNSLNIANELAERPNIEVILLGGELRPSSGSLVGPLAEE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 160 FVKQFRLDFGILGISGIDFDGSLLDFDYHEVRVKQAIIDNSRSILLAVDHSKFGRNAMVKLGNISQAHMVFTNKQPPEEI 239
Cdd:COG1349 160 ALRRFRADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPEL 239
|
250
....*....|...
gi 657925904 240 TNILKDFSIPLEV 252
Cdd:COG1349 240 LEALEEAGVEVIV 252
|
|
| DeoRC |
pfam00455 |
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ... |
73-233 |
2.86e-63 |
|
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395365 Cd Length: 160 Bit Score: 195.42 E-value: 2.86e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 73 LNFNEKDVIADQLVKHIPDGATLFVDIGTTPESVARALNkNHKQLRVVTNNINVASILLSNPEIKVILAGGEVRNRDGGI 152
Cdd:pfam00455 1 ENAEEKRRIAKAAASLIEDGDTIFLDAGTTTLELARALP-DRRNLTVITNSLNIANELSEKPDIEVILLGGEVRPKTGAF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 153 VGEATLDFVKQFRLDFGILGISGIDFDGSLLDFDYHEVRVKQAIIDNSRSILLAVDHSKFGRNAMVKLGNISQAHMVFTN 232
Cdd:pfam00455 80 VGPLAEEFLRQFNVDKAFIGANGIDLEGGLTTSDEEEAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITD 159
|
.
gi 657925904 233 K 233
Cdd:pfam00455 160 K 160
|
|
| TranRegGlpR_Halo |
NF041397 |
HTH-type transcriptional regulator GlpR; |
6-239 |
3.38e-50 |
|
HTH-type transcriptional regulator GlpR;
Pssm-ID: 469288 [Multi-domain] Cd Length: 253 Bit Score: 165.08 E-value: 3.38e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 6 RHQQIVDLVKTQGYVSTEELVEKFDVSPQTIRRDLNELADNNKIRRYHGGAtIPLSSENT--SYSTRKALNFNEKDVIAD 83
Cdd:NF041397 6 RKRKIVELVTERDGCSVEELADELDVSKATIRRDLRDLEDRGLIERSHGGA-VPVTSVGRerSYGQREVQNLEAKRAIAE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 84 QLVKHIPDGATLFVDIGTTPESVARALNKNHKQLrVVTNNINVASILLSNpEIKVILAGGEVRNRDGGIVGEATLDFVKQ 163
Cdd:NF041397 85 RAVEEIHDGQVVFFDAGTTTMEVAKRVPTDGSFL-AVTNSPLLALELAER-DGEVKLTGGTLRPRTRALVGPTAESFMER 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 657925904 164 FRLDFGILGISGIDFDGSLLDFDYHEVRVKQAIIDNSRSILLAVDHSKFGRNAMVKLGNISQAHMVFTNKQPPEEI 239
Cdd:NF041397 163 TNFDLLFLGTNGIDPDGGLTTPNEDEARMKELMVENAKRVVLVADGSKFGERSFVRFADLDDVDLFVTDGALPEEL 238
|
|
| AgaR |
NF040755 |
transcriptional repressor AgaR; |
6-253 |
4.36e-35 |
|
transcriptional repressor AgaR;
Pssm-ID: 468715 [Multi-domain] Cd Length: 256 Bit Score: 126.23 E-value: 4.36e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 6 RHQQIVDLVKTQGYVSTEELVEKFDVSPQTIRRDLNELADNNKIRRYHGGATI---PLSSENTSYSTRKALNFNEKDVIA 82
Cdd:NF040755 7 RREQIIQRLRQQGSVQVEDLSALFGVSTVTIRNDLAFLEKQGIAVRAYGGALIndgFIPGAEPSVEDKSRLNTAVKRLIA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 83 DQLVKHIPDGATLFVDIGTTPESVARALnKNHKQLRVVTNNINVASILLSNPEIKVILAGGEVRNRDGGIVGEATLDFVK 162
Cdd:NF040755 87 AAAAELIKPGDRVILDSGTTTYEIARHL-KQHQDVVVMTNGLNVANELLEAEGVEVLMTGGHLRRQSLSFYGDQAEQSLQ 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 163 QFRLDFGILGISGIDFDGSLLDFDYHEVRVKQAIIDNSRSILLAVDHSKFGRNAMVKLGNISQAHMVFTNKQPPEEITNI 242
Cdd:NF040755 166 NYHFDKLFLGVDGFDLERGITTHNEDEARLNRRMCEVAERIIAVTDSSKFGRSSLHKIRDTGRIDTLITDSGIPEEYLQG 245
|
250
....*....|.
gi 657925904 243 LKDFSIplEVI 253
Cdd:NF040755 246 LRKLGV--EVI 254
|
|
| HTH_DEOR |
smart00420 |
helix_turn_helix, Deoxyribose operon repressor; |
6-56 |
8.55e-19 |
|
helix_turn_helix, Deoxyribose operon repressor;
Pssm-ID: 197714 [Multi-domain] Cd Length: 53 Bit Score: 77.65 E-value: 8.55e-19
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 657925904 6 RHQQIVDLVKTQGYVSTEELVEKFDVSPQTIRRDLNELADNNKIRRYHGGA 56
Cdd:smart00420 1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGA 51
|
|
| WHTH_GntR |
cd07377 |
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ... |
5-58 |
4.21e-03 |
|
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.
Pssm-ID: 153418 [Multi-domain] Cd Length: 66 Bit Score: 35.12 E-value: 4.21e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 657925904 5 PRHQQIVDLVKTQ--------GY--VSTEELVEKFDVSPQTIRRDLNELADNNKIRRYHGGATI 58
Cdd:cd07377 1 PLYEQIADQLREAilsgelkpGDrlPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTF 64
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10906 |
PRK10906 |
DeoR/GlpR family transcriptional regulator; |
1-252 |
1.53e-132 |
|
DeoR/GlpR family transcriptional regulator;
Pssm-ID: 182827 [Multi-domain] Cd Length: 252 Bit Score: 374.58 E-value: 1.53e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 1 MKQIPRHQQIVDLVKTQGYVSTEELVEKFDVSPQTIRRDLNELADNNKIRRYHGGATIPLSSENTSYSTRKALNFNEKDV 80
Cdd:PRK10906 1 MKQTQRHDAIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNDLAEQNKILRHHGGAALPSSSVNTPWHDRKATQTEEKER 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 81 IADQLVKHIPDGATLFVDIGTTPESVARALnKNHKQLRVVTNNINVASILLSNPEIKVILAGGEVRNRDGGIVGEATLDF 160
Cdd:PRK10906 81 IARKVASQIPNGATLFIDIGTTPEAVAHAL-LNHSNLRIVTNNLNVANTLMAKEDFRIILAGGELRSRDGGIIGEATLDF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 161 VKQFRLDFGILGISGIDFDGSLLDFDYHEVRVKQAIIDNSRSILLAVDHSKFGRNAMVKLGNISQAHMVFTNKQPPEEIT 240
Cdd:PRK10906 160 ISQFRLDFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDQLPPASVM 239
|
250
....*....|..
gi 657925904 241 NILKDFSIPLEV 252
Cdd:PRK10906 240 QVIEDHHVQLEL 251
|
|
| GlpR |
COG1349 |
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ... |
1-252 |
2.25e-103 |
|
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];
Pssm-ID: 440960 [Multi-domain] Cd Length: 254 Bit Score: 300.51 E-value: 2.25e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 1 MKQIPRHQQIVDLVKTQGYVSTEELVEKFDVSPQTIRRDLNELADNNKIRRYHGGAT-IPLSSENTSYSTRKALNFNEKD 79
Cdd:COG1349 1 MLAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVlVSSAAAEPPFAERETLNAEEKR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 80 VIADQLVKHIPDGATLFVDIGTTPESVARALnKNHKQLRVVTNNINVASILLSNPEIKVILAGGEVRNRDGGIVGEATLD 159
Cdd:COG1349 81 AIARAAASLIEDGDTIFLDAGTTTLALARAL-PDRRNLTVVTNSLNIANELAERPNIEVILLGGELRPSSGSLVGPLAEE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 160 FVKQFRLDFGILGISGIDFDGSLLDFDYHEVRVKQAIIDNSRSILLAVDHSKFGRNAMVKLGNISQAHMVFTNKQPPEEI 239
Cdd:COG1349 160 ALRRFRADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPEL 239
|
250
....*....|...
gi 657925904 240 TNILKDFSIPLEV 252
Cdd:COG1349 240 LEALEEAGVEVIV 252
|
|
| DeoRC |
pfam00455 |
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ... |
73-233 |
2.86e-63 |
|
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395365 Cd Length: 160 Bit Score: 195.42 E-value: 2.86e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 73 LNFNEKDVIADQLVKHIPDGATLFVDIGTTPESVARALNkNHKQLRVVTNNINVASILLSNPEIKVILAGGEVRNRDGGI 152
Cdd:pfam00455 1 ENAEEKRRIAKAAASLIEDGDTIFLDAGTTTLELARALP-DRRNLTVITNSLNIANELSEKPDIEVILLGGEVRPKTGAF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 153 VGEATLDFVKQFRLDFGILGISGIDFDGSLLDFDYHEVRVKQAIIDNSRSILLAVDHSKFGRNAMVKLGNISQAHMVFTN 232
Cdd:pfam00455 80 VGPLAEEFLRQFNVDKAFIGANGIDLEGGLTTSDEEEAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITD 159
|
.
gi 657925904 233 K 233
Cdd:pfam00455 160 K 160
|
|
| TranRegGlpR_Halo |
NF041397 |
HTH-type transcriptional regulator GlpR; |
6-239 |
3.38e-50 |
|
HTH-type transcriptional regulator GlpR;
Pssm-ID: 469288 [Multi-domain] Cd Length: 253 Bit Score: 165.08 E-value: 3.38e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 6 RHQQIVDLVKTQGYVSTEELVEKFDVSPQTIRRDLNELADNNKIRRYHGGAtIPLSSENT--SYSTRKALNFNEKDVIAD 83
Cdd:NF041397 6 RKRKIVELVTERDGCSVEELADELDVSKATIRRDLRDLEDRGLIERSHGGA-VPVTSVGRerSYGQREVQNLEAKRAIAE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 84 QLVKHIPDGATLFVDIGTTPESVARALNKNHKQLrVVTNNINVASILLSNpEIKVILAGGEVRNRDGGIVGEATLDFVKQ 163
Cdd:NF041397 85 RAVEEIHDGQVVFFDAGTTTMEVAKRVPTDGSFL-AVTNSPLLALELAER-DGEVKLTGGTLRPRTRALVGPTAESFMER 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 657925904 164 FRLDFGILGISGIDFDGSLLDFDYHEVRVKQAIIDNSRSILLAVDHSKFGRNAMVKLGNISQAHMVFTNKQPPEEI 239
Cdd:NF041397 163 TNFDLLFLGTNGIDPDGGLTTPNEDEARMKELMVENAKRVVLVADGSKFGERSFVRFADLDDVDLFVTDGALPEEL 238
|
|
| AgaR |
NF040755 |
transcriptional repressor AgaR; |
6-253 |
4.36e-35 |
|
transcriptional repressor AgaR;
Pssm-ID: 468715 [Multi-domain] Cd Length: 256 Bit Score: 126.23 E-value: 4.36e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 6 RHQQIVDLVKTQGYVSTEELVEKFDVSPQTIRRDLNELADNNKIRRYHGGATI---PLSSENTSYSTRKALNFNEKDVIA 82
Cdd:NF040755 7 RREQIIQRLRQQGSVQVEDLSALFGVSTVTIRNDLAFLEKQGIAVRAYGGALIndgFIPGAEPSVEDKSRLNTAVKRLIA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 83 DQLVKHIPDGATLFVDIGTTPESVARALnKNHKQLRVVTNNINVASILLSNPEIKVILAGGEVRNRDGGIVGEATLDFVK 162
Cdd:NF040755 87 AAAAELIKPGDRVILDSGTTTYEIARHL-KQHQDVVVMTNGLNVANELLEAEGVEVLMTGGHLRRQSLSFYGDQAEQSLQ 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 163 QFRLDFGILGISGIDFDGSLLDFDYHEVRVKQAIIDNSRSILLAVDHSKFGRNAMVKLGNISQAHMVFTNKQPPEEITNI 242
Cdd:NF040755 166 NYHFDKLFLGVDGFDLERGITTHNEDEARLNRRMCEVAERIIAVTDSSKFGRSSLHKIRDTGRIDTLITDSGIPEEYLQG 245
|
250
....*....|.
gi 657925904 243 LKDFSIplEVI 253
Cdd:NF040755 246 LRKLGV--EVI 254
|
|
| PRK09802 |
PRK09802 |
DeoR family transcriptional regulator; |
6-253 |
1.98e-30 |
|
DeoR family transcriptional regulator;
Pssm-ID: 182086 [Multi-domain] Cd Length: 269 Bit Score: 114.57 E-value: 1.98e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 6 RHQQIVDLVKTQGYVSTEELVEKFDVSPQTIRRDLNELADNNKIRRYHGGATIPLS---SENTSYSTRKALNFNEKDVIA 82
Cdd:PRK09802 18 RREQIIQRLRQQGSVQVNDLSALYGVSTVTIRNDLAFLEKQGIAVRAYGGALICDSttpSVEPSVEDKSALNTAMKRSVA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 83 DQLVKHIPDGATLFVDIGTTPESVARALnKNHKQLRVVTNNINVASILLSNPEIKVILAGGEVRNRDGGIVGEATLDFVK 162
Cdd:PRK09802 98 KAAVELIQPGHRVILDSGTTTFEIARLM-RKHTDVIAMTNGMNVANALLEAEGVELLMTGGHLRRQSQSFYGDQAEQSLQ 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 163 QFRLDFGILGISGIDFDGSLLDFDYHEVRVKQAIIDNSRSILLAVDHSKFGRNAMVKLGNISQAHMVFTNKQPPEEITNI 242
Cdd:PRK09802 177 NYHFDMLFLGVDAIDLERGVSTHNEDEARLNRRMCEVAERIIVVTDSSKFNRSSLHKIIDTQRIDMIIVDEGIPADSLEG 256
|
250
....*....|.
gi 657925904 243 LKDFSIplEVI 253
Cdd:PRK09802 257 LRKAGV--EVI 265
|
|
| PRK10411 |
PRK10411 |
L-fucose operon activator; |
6-236 |
1.48e-26 |
|
L-fucose operon activator;
Pssm-ID: 236684 [Multi-domain] Cd Length: 240 Bit Score: 103.35 E-value: 1.48e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 6 RHQQIVDLVKTQGYVSTEELVEKFDVSPQTIRRDLNELADNNKIRRYHGGATIpLSSENTS----YSTRKALNFNEKDVI 81
Cdd:PRK10411 5 RQQAIVDLLLNHTSLTTEALAEQLNVSKETIRRDLNELQTQGKILRNHGRAKY-IHRQNQDsgdpFHIRLKSHYAHKADI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 82 ADQLVKHIPDGATLFVDIGTTPESVARALNKnhKQLRVVTNNINVASILLSNPEIKVILAGGEVRNRDGGIVGEATLDFV 161
Cdd:PRK10411 84 AREALAWIEEGMVIALDASSTCWYLARQLPD--INIQVFTNSHPICQELGKRERIQLISSGGTLERKYGCYVNPSLISQL 161
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 657925904 162 KQFRLDFGILGISGIDFDGSLLDFDYHEVRVKQAIIDNSRSILLAVDHSKFGRNAMVKLGNISQAHMVFTNKQPP 236
Cdd:PRK10411 162 KSLEIDLFIFSCEGIDSSGALWDSNAINADYKSMLLKRAAQSLLLIDKSKFNRSGEARIGHLDEVTHIISDERQV 236
|
|
| srlR |
PRK10434 |
DNA-binding transcriptional repressor; |
1-253 |
1.43e-22 |
|
DNA-binding transcriptional repressor;
Pssm-ID: 182457 [Multi-domain] Cd Length: 256 Bit Score: 93.21 E-value: 1.43e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 1 MKQIPRHQQIVDLVKTQGYVSTEELVEKFDVSPQTIRRDLNELADNNKIRRYHGGATIPLSSENTSYSTRKALNFNEKDV 80
Cdd:PRK10434 1 MKPRQRQAAILEYLQKQGKTSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVLNKEESDPPIDHKTLINTHKKEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 81 IADQLVKHIPDGATLFVDIGTTPESVARALNKnHKQLRVVTNNINVASILLS-NPEIKVILAGGEVRNRDG---GIVGEA 156
Cdd:PRK10434 81 IAEAAVSLIHDGDSIILDAGSTVLQMVPLLSR-FNNITVMTNSLHIVNALSElDNEQTILMPGGTFRKKSAsfhGQLAEN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 157 TldfVKQFRLDFGILGISGIDFDGSLLDFDyhEV-RVKQAIIDNSRSILLAVDHSKFGR---NAMVKLGNIsqaHMVFTN 232
Cdd:PRK10434 160 A---FEHFTFDKLFIGTDGIDLNAGVTTFN--EVyTVSKAMCNAAREIILMADSSKFGRkspNVVCSLEKV---DKLITD 231
|
250 260
....*....|....*....|.
gi 657925904 233 KQPPEEITNILKDFSIplEVI 253
Cdd:PRK10434 232 AGIDPAFRQALEEKGI--EVI 250
|
|
| HTH_DeoR |
pfam08220 |
DeoR-like helix-turn-helix domain; |
6-59 |
1.69e-19 |
|
DeoR-like helix-turn-helix domain;
Pssm-ID: 285436 [Multi-domain] Cd Length: 57 Bit Score: 79.61 E-value: 1.69e-19
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 657925904 6 RHQQIVDLVKTQGYVSTEELVEKFDVSPQTIRRDLNELADNNKIRRYHGGATIP 59
Cdd:pfam08220 1 RIQQILELLKQQGTLSVEELAELLGVSEMTIRRDLNELEEQGLLTRTHGGAVSN 54
|
|
| HTH_DEOR |
smart00420 |
helix_turn_helix, Deoxyribose operon repressor; |
6-56 |
8.55e-19 |
|
helix_turn_helix, Deoxyribose operon repressor;
Pssm-ID: 197714 [Multi-domain] Cd Length: 53 Bit Score: 77.65 E-value: 8.55e-19
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 657925904 6 RHQQIVDLVKTQGYVSTEELVEKFDVSPQTIRRDLNELADNNKIRRYHGGA 56
Cdd:smart00420 1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGA 51
|
|
| PRK13509 |
PRK13509 |
HTH-type transcriptional regulator UlaR; |
1-245 |
9.61e-19 |
|
HTH-type transcriptional regulator UlaR;
Pssm-ID: 184100 [Multi-domain] Cd Length: 251 Bit Score: 82.75 E-value: 9.61e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 1 MKQIPRHQQIVDLVKTQGYVSTEELVEKFDVSPQTIRRDLNELADNNKIRRYHGGA-----TIPLSSENTSYSTRkalNF 75
Cdd:PRK13509 1 MTEAQRHQILLELLAQLGFVTVEKVIERLGISPATARRDINKLDESGKLKKVRNGAeaitqQRPRWTPMNIHQAQ---NH 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 76 NEKDVIADQLVKHIPDGATLFVDIGTTPESVARALnkNHKQLRVVTNNINVASILLSNPEIKVILAGGEVrNRDGGIV-- 153
Cdd:PRK13509 78 DEKVRIAKAASQLCNPGESVVINCGSTAFLLGREL--CGKPVQIITNYLPLANYLIDQEHDSVIIMGGQY-NKSQSITls 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 154 --GEATLDFVKQFRLDFGilgiSGIDFDGsLLDFDYHEVRVKQAIIDNSRSILLAVDHSKFGRNAMVKLGNISQAHMVFT 231
Cdd:PRK13509 155 pqGSENSLYAGHWMFTSG----KGLTADG-LYKTDMLTAMAEQKMLSVVGKLVVLVDSSKIGERAGMLFSRADQIDMLIT 229
|
250
....*....|....
gi 657925904 232 NKQPPEEITNILKD 245
Cdd:PRK13509 230 GKNADPEVLQQLEA 243
|
|
| PRK10681 |
PRK10681 |
DNA-binding transcriptional repressor DeoR; Provisional |
31-250 |
1.59e-12 |
|
DNA-binding transcriptional repressor DeoR; Provisional
Pssm-ID: 182644 [Multi-domain] Cd Length: 252 Bit Score: 65.49 E-value: 1.59e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 31 VSPQTIRRDLNelADNNKIRRYhGGATI--PLSSENTSYSTRKALNFNEKDVIADQLVKHIPDGATLFVDIGTTPESVAR 108
Cdd:PRK10681 33 VSEMTIRRDLN--AHSAPVVLL-GGYIVlePRSASHYLLSDQKSRLVEEKRRAAQLAATLVEPNQTLFFDCGTTTPWIIE 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 109 ALNkNHKQLRVVTNNINVASILLSNPEIKVILAGGEVRNrDGGIVG----EATLDfvkQFRLDFGILGISGIDFDGSLLD 184
Cdd:PRK10681 110 AID-NELPFTAVCYSLNTFLALQEKPHCRAILCGGEFHA-SNAIFKpldfQQTLD---NICPDIAFYSAAGVHVSKGATC 184
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 657925904 185 FDYHEVRVKQAIIDNSRSILLAVDHSKFGRNAMVKLGNISQAHMVFTNKQPPEEITNILKDFSIPL 250
Cdd:PRK10681 185 FNLEELPVKHWAMAMAQKHVLVVDHSKFGKVRPARMGDLTRFDTVVSDRCPDDEFVKYAQAQRIKL 250
|
|
| YobV |
COG2378 |
Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains ... |
1-112 |
3.79e-07 |
|
Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains [Transcription];
Pssm-ID: 441945 [Multi-domain] Cd Length: 314 Bit Score: 50.08 E-value: 3.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 1 MKQIPRHQQIVDLVKTQGYVSTEELVEKFDVSPQTIRRDLNEL--------ADNNKIRRYH--GGATIPLssentsystr 70
Cdd:COG2378 1 MSRLERLLALLQLLQSRRGVTAAELAERLEVSERTIYRDIDALrelgvpieAERGRGGGYRlrDGYRLPP---------- 70
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 657925904 71 kaLNFNEKD----VIADQLVKHIPDGATLfvdigttpESVARALNK 112
Cdd:COG2378 71 --LMLTEEEalalLLALRLLAALGGAPLA--------EAAASALAK 106
|
|
| MngR |
COG2188 |
DNA-binding transcriptional regulator, GntR family [Transcription]; |
4-111 |
7.39e-05 |
|
DNA-binding transcriptional regulator, GntR family [Transcription];
Pssm-ID: 441791 [Multi-domain] Cd Length: 238 Bit Score: 42.93 E-value: 7.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657925904 4 IPRHQQIVDLVKTQ--------GYV--STEELVEKFDVSPQTIRRDLNELADNNKIRRYHGGATIpLSSENTSYSTRKAL 73
Cdd:COG2188 4 VPLYLQIADALRERiesgelppGDRlpSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTF-VAEPKIEYPLSRLT 82
|
90 100 110
....*....|....*....|....*....|....*...
gi 657925904 74 NFneKDVIADQlvKHIPDGATLFVDIGTTPESVARALN 111
Cdd:COG2188 83 SF--TEELRAR--GREPSTRVLSAERVPADEEVAEALG 116
|
|
| HTH_11 |
pfam08279 |
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins. |
13-43 |
3.23e-04 |
|
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
Pssm-ID: 429896 [Multi-domain] Cd Length: 52 Bit Score: 37.80 E-value: 3.23e-04
10 20 30
....*....|....*....|....*....|.
gi 657925904 13 LVKTQGYVSTEELVEKFDVSPQTIRRDLNEL 43
Cdd:pfam08279 7 LLEARGPISGQELAEKLGVSRRTIRRDIKIL 37
|
|
| GntR |
pfam00392 |
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ... |
23-57 |
9.86e-04 |
|
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.
Pssm-ID: 306822 [Multi-domain] Cd Length: 64 Bit Score: 36.82 E-value: 9.86e-04
10 20 30
....*....|....*....|....*....|....*
gi 657925904 23 EELVEKFDVSPQTIRRDLNELADNNKIRRYHGGAT 57
Cdd:pfam00392 28 RELAAEFGVSRTTVREALRRLEAEGLVERRQGRGT 62
|
|
| HTH_GNTR |
smart00345 |
helix_turn_helix gluconate operon transcriptional repressor; |
21-57 |
1.05e-03 |
|
helix_turn_helix gluconate operon transcriptional repressor;
Pssm-ID: 197669 [Multi-domain] Cd Length: 60 Bit Score: 36.40 E-value: 1.05e-03
10 20 30
....*....|....*....|....*....|....*..
gi 657925904 21 STEELVEKFDVSPQTIRRDLNELADNNKIRRYHGGAT 57
Cdd:smart00345 22 SERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGT 58
|
|
| ArgR |
COG1438 |
Arginine repressor [Transcription]; |
1-43 |
2.58e-03 |
|
Arginine repressor [Transcription];
Pssm-ID: 441047 Cd Length: 152 Bit Score: 37.42 E-value: 2.58e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 657925904 1 MKQIPRHQQIVDLVKTQGYVSTEELVEK-----FDVSPQTIRRDLNEL 43
Cdd:COG1438 1 MKKAARQAKIKEIISEEEIETQEELVELlkeegFNVTQATVSRDLKEL 48
|
|
| PRK04424 |
PRK04424 |
transcription factor FapR; |
6-44 |
2.64e-03 |
|
transcription factor FapR;
Pssm-ID: 179847 [Multi-domain] Cd Length: 185 Bit Score: 37.88 E-value: 2.64e-03
10 20 30
....*....|....*....|....*....|....*....
gi 657925904 6 RHQQIVDLVKTQGYVSTEELVEKFDVSPQTIRRDLNELA 44
Cdd:PRK04424 8 RQKALQELIEENPFITDEELAEKFGVSIQTIRLDRMELG 46
|
|
| CoA_trans |
smart00882 |
Coenzyme A transferase; Coenzyme A (CoA) transferases belong to an evolutionary conserved ... |
81-144 |
3.31e-03 |
|
Coenzyme A transferase; Coenzyme A (CoA) transferases belong to an evolutionary conserved family of enzymes catalyzing the reversible transfer of CoA from one carboxylic acid to another. They have been identified in many prokaryotes and in mammalian tissues. The bacterial enzymes are heterodimer of two subunits (A and B) of about 25 Kd each while eukaryotic SCOT consist of a single chain which is colinear with the two bacterial subunits.
Pssm-ID: 214882 [Multi-domain] Cd Length: 212 Bit Score: 37.57 E-value: 3.31e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 657925904 81 IADQLVKHIPDGATL----FVDIGTTPESVARALNKNHKQLRVVTNN-INVASILLSNPEIKVILAGGE 144
Cdd:smart00882 1 SAAEAAREIKDGDTValggFGGLPTPAALILALIRQGPKDLTLISENgGLGLGLLAGEGDVKKIIAGHV 69
|
|
| WHTH_GntR |
cd07377 |
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ... |
5-58 |
4.21e-03 |
|
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.
Pssm-ID: 153418 [Multi-domain] Cd Length: 66 Bit Score: 35.12 E-value: 4.21e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 657925904 5 PRHQQIVDLVKTQ--------GY--VSTEELVEKFDVSPQTIRRDLNELADNNKIRRYHGGATI 58
Cdd:cd07377 1 PLYEQIADQLREAilsgelkpGDrlPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTF 64
|
|
| |
