|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
14-380 |
2.76e-62 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 204.32 E-value: 2.76e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 14 ILIMAITAGVSVASLYYVQPILDEVSKSLHKSENEVGLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVLVLALFG 93
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 94 MALIHNLYGIYLMSLIIG-AMGAAAQVVMPMAATLATENK-GKIVGMVFTGLLSGILLARVVSGYSARLWGWQSIYMISA 171
Cdd:cd17324 81 AALAPSFALLLLARALAGlAHGGFWAIAAAYAADLVPPEKrGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 172 FVIMIMMVLVYFTLPNVGTQFSGTYGelLKSTIAQYKRFPKLRRLSIIGALVFGVFCSFWTTITFHLTGEPFFLKSDKIG 251
Cdd:cd17324 161 VLALLAALLLWRLLPSLPPKKPGSLG--LLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 252 LLGIVALGGALVAPVVGRMADKGsPARGILYSILVVVASVILMMVFPSNIWMIVFSVFIMDVGVQAMQITNIATIYTLDE 331
Cdd:cd17324 239 LLLLFGVAGVVGSPLAGRLADRG-GRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 658545624 332 SANSRINTVYMTCYFIGGALGTVLGVNCWHYGGWNFVLIQFMVLLVAAV 380
Cdd:cd17324 318 EARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLAL 366
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
11-351 |
1.17e-33 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 128.17 E-value: 1.17e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 11 RLQILIMAITAGVSVASLYYVQPILDEVSKSLHKSENEVGLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVLVLA 90
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 91 LFGMALIHNLYGIYLMSLIIG-AMGAAAQVVMPMAATLAT-ENKGKIVGMVFTGLLSGILLARVVSGYSARLWGWQSIYM 168
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGlGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 169 ISAFVIMIMMVLVYFTLPNVGTQFSGTygelLKSTIAQYKRFPKLRRLSIIGALVFGVFCSFWTTITFHLTGEPFFLKSD 248
Cdd:COG2814 169 VNAVLALLALLLLLRLLPESRPAARAR----LRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 249 KIGLLGIVALGGALVAPVVGRMADKGSPARGILYSILVVVASvILMMVFPSNIWMIVFSVFIMDVGVQAMQITNIATIYT 328
Cdd:COG2814 245 AGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG-LLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAE 323
|
330 340
....*....|....*....|....
gi 658545624 329 L-DESANSRINTVYMTCYFIGGAL 351
Cdd:COG2814 324 LaPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-353 |
1.37e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 91.71 E-value: 1.37e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 17 MAITAGVSVASLYYVQPILDE-VSKSLHKSENEVGLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVLVLALFGMA 95
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 96 LIHNLYGIYLMSLIIGAMGAAAQVVMP--MAATLATENKGKIVGMVFTGLLSGILLARVVSGYSARLWGWQSIYMISAFV 173
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALalIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 174 IMIMMVLVYFTLPNVGTQFSGTYGELLKSTIAQYKRFPKLRRLSIIGALVFGVFCSFWTTITFHLTGEPF-FLKSDKIGL 252
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLgLSALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 253 LGIVALGGALVAPVVGRMADKGSPARGIL--YSILVVVASVILMMVFPSNIWMIVFSVFIMDVGVQAMQITNIATIYTL- 329
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLlaLLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLa 320
|
330 340
....*....|....*....|....
gi 658545624 330 DESANSRINTVYMTCYFIGGALGT 353
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
19-385 |
2.83e-20 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 91.48 E-value: 2.83e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 19 ITAGVSVASLYY--VQPILDEVSKSLHKSENEVGLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVLVLALFGMAL 96
Cdd:cd17325 1 LSLALFLDMLGYgiIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 97 IHNLYGIYLMSLIIGAMGAAAQVV-MPMAATLAT-ENKGKIVGMVFTGLLSGILLARVVSGYSARLWGWQSIYMISAFVI 174
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAaMALIADIAPpEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 175 MIMMVLVYFTLP--NVGTQFSGTYGELLKSTIAQYKRFPKLRRLSIIGALVFGVFCSFWTTITFHLTGEpFFLKSDKIGL 252
Cdd:cd17325 161 LLALVLALLLLPepRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAEL-GGLSPAQIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 253 L-GIVALGGALVAPVVGRMADKGSPARGILYSILVVVASVILmMVFPSNIWMIVFSVFIMDVGVQAMQITNIATI-YTLD 330
Cdd:cd17325 240 LfGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLL-LPLATSFWLLLLLLALLGLGLGLVFPATLALLaDIVP 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 658545624 331 ESANSRINTVYMTCYFIGGALGTVLGVNCWHYGGWNFVLIQFMVLLVAAVCIAVV 385
Cdd:cd17325 319 PEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
11-385 |
7.07e-20 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 90.33 E-value: 7.07e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 11 RLQILIMAITAGVSVASLYYVQPILDEVSKSLHKSENEVGLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVLVLA 90
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 91 LFGMALIHNLYGIYLMSLIIG-AMGAAAQVVMPMAATL-ATENKGKIVGMVFTGLLSGILLARVVSGYSARLWGWQSIYM 168
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGiGGGGSFAVGIALVSKWfPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 169 ISAFVIMIMMVLVYFTLPNVGTQFSGTYGELLKSTIAQYKRfPKLRRLSIIGALVFGVFCSFWTTITFHLTGEPFFLKSD 248
Cdd:COG2223 164 ILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRD-PRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAAT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 249 KIGLLGIVALGGALVAPVVGRMADKGSPARGILYSILVVVASVILMMVFPSNIWMIVFSVFIMDVGVQAMQITNIATIYT 328
Cdd:COG2223 243 AGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPD 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 658545624 329 LDESANSRINT--VYMTCYFIGGALGTVLGVNCWHYGGWNFVLIQFMVLLVAAVCIAVV 385
Cdd:COG2223 323 IFPTKNAGAVYglVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLL 381
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
51-385 |
5.89e-17 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 81.49 E-value: 5.89e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 51 LLPALAQAGYGLG-LFFITPYG---DKMNRKKLILLMLFVLVLALFGMALIHNLYGIYLMSLIIGAmGAAAQVVMPMAAT 126
Cdd:cd17472 32 TLIGLALGIYGLTqAIFQIPFGllsDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS-GAISSVVMALLAD 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 127 LaTENKGKIVGMVFTGLLSGI--LLARVVSGYSARLWGWQSIYMISAFVIMIMMVLVYFTLPNVgtQFSGTYGELLKSTI 204
Cdd:cd17472 111 L-TREENRTKAMALIGASIGIafAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDP--PKIVQISEKEKKKL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 205 AQYKRFPKLRRLSIIGALVFGVFCSFWTTITFHLTGEPFFLKSDKIGLLGIVALGGALVAPVVGRMADKGSPARGILYSI 284
Cdd:cd17472 188 KKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAEKKGKMKQVFVSSI 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 285 LVVVASVILMMVFPSNIWMIVFSVFIMDVGVQAMQITNIATIyTLDESANSR--INTVYMTCYFIGGALGTVLGVNCWHY 362
Cdd:cd17472 268 LLIAVGFLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLV-SKIAPKEYRgtAMGIYNTSQFLGSFLGGALGGLLWGL 346
|
330 340
....*....|....*....|...
gi 658545624 363 GGWNFVLIQFMVLLVAAVCIAVV 385
Cdd:cd17472 347 LGYSSVFLTILILALLWLLVSFL 369
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
14-384 |
4.23e-15 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 76.07 E-value: 4.23e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 14 ILIMAITAGVSVASlyyVQPILDEVSKSLHKSENEVGLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVLVLALFG 93
Cdd:COG2807 23 IVLVALNLRPAITS---VGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 94 MALIHNLYGIYLMSLIIGAMGAAAQVVMP-MAATLATENKGKIVGMVFTGLLSGILLARVVSGYSARLWGWQSIYMISAF 172
Cdd:COG2807 100 RSLAPSVALLLAGTALIGAGIAVGNVLLPgLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWAL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 173 VIMIMMVLVYFTLPNVGTQFSGTYGELLKSTIAQYKRFPKLrrlsiigALVFGVFCSFWTTITFHLtgePFFLKSDKIG- 251
Cdd:COG2807 180 LALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLL-------TLFFGLQSLLYYAVVAWL---PPILRDAGLSa 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 252 -----LLGIVALGGALVAPVVGRMADKGSPARGILYSILVV-VASVILMMVFPSniWMIVFSVFIMDVGVQAMQITNIAT 325
Cdd:COG2807 250 ataglLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLgLAGLLGLLLAPG--SLPWLWAVLLGLGQGGLFPLALTL 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 658545624 326 I--YTLDESANSRINTVYMTCYFIGGALGTVL-GVNCWHYGGWNFVLIQFMVLLVAAVCIAV 384
Cdd:COG2807 328 IglRARTPAEAAALSGMAQSVGYLLAALGPLLvGALHDATGSWTAALLLLAALAVLMLVAGL 389
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
11-385 |
1.04e-14 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 74.91 E-value: 1.04e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 11 RLQILIMAITAGVSVASLYYVQPIL-DEVSKSLHKSENEVGLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVLVL 89
Cdd:COG2271 8 RWRILALLFLAYFLNYLDRSNLSVAaPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 90 ALFGMALIHNLYGIYLMSLIIGAMGAAAQVVMP--MAATLATENKGKIVGMVFTGLLSGILLARVVSGYSARLWGWQSIY 167
Cdd:COG2271 88 ATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALklIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 168 MISAFVIMIMMVLvyftlpnvgtqfsgtygellkstiaqykrfpKLRRLSIIGALVFGVFCSFWTTITFHLTGEPFFLKS 247
Cdd:COG2271 168 LILGLPGLLLALL-------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 248 DKIGLLGIVALGGALVAPVVGRMADK-GSPARGILYSILVVVASVILMMVFPSNIWMIVFSVFIMDVGVQAMQ-ITNIAT 325
Cdd:COG2271 217 QAGLLLSLPFLAGIVGSLLGGWLSDRlGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFgLLWALA 296
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 326 IYTLDESANSRINTVYMTCYFIGGALGTVLGVNCWHYGGWNFVLIQFMVLLVAAVCIAVV 385
Cdd:COG2271 297 AELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALL 356
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
31-385 |
5.26e-14 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 72.60 E-value: 5.26e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 31 VQPILDEVSKSLHKSENEVGLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVLVLALFGMALIHNLYGIyLMSLII 110
Cdd:cd17474 18 VDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALL-LAGRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 111 GAMGAAA--QVVMPMAATLATENK-GKIVGMVFTGLLSGILLARVVSGYSArLWGWQSIYMISAFVIMIMMVLVYFTLPN 187
Cdd:cd17474 97 QGIGAAGlgPLALTLIGDLFEGGErAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAALIPVAFLAILFLLPE 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 188 VGTQFSGTYGELLKSTIAQYKRfPKLRRLSIIGALVFGVFCSFWTTITFHLtGEPFFLKSDKIGLL-GIVALGGALVAPV 266
Cdd:cd17474 176 PKEKAKSSSATKLRDLKKALRG-RGLLTFLVSAFLYFFLYFAFLTYLPFLL-ELLYGISPIIIGLLfAGWSVLLALGSLF 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 267 VGRMADKGSPARGILYSILVVVASVILMMVFPSNIWMIVFSVFIMDVGvQAMQITNIATIYTldESANSRINTVYMTCY- 345
Cdd:cd17474 254 VGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLG-LGLNLPLLTTLVT--ELAPEEERGTASSLYn 330
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 658545624 346 ---FIGGALGTVLGVNCWHYGGWNFVliqFMVLLVAAVCIAVV 385
Cdd:cd17474 331 fvrFLGQAVGPLLFGLLLEIFGLSAP---FLVGAAIALAAAVL 370
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
14-382 |
3.57e-13 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 70.30 E-value: 3.57e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 14 ILIMAITAGVSVASLYYVQPILDEVSKSLHKSENEVGLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVLVLALFG 93
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 94 MALIHNLYGIYLMSLIIGaMGAAAQVVMPMAA---TLATENKGKIVGMVFTGLLSGILLARVVSGYSARLWGWQSIYMIS 170
Cdd:cd17320 81 CALASSIEQLLIARFLQG-LGAAAGSVVARAIvrdLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 171 AFVIMIMMVLVYFTLPnvGTQFSGTYGELLKSTIAQYKRF---PKLRRLSIIGALVFGVFCSFWTTITFHLTGEPFFLKS 247
Cdd:cd17320 160 ALLGLLLLLLVLLFLP--ETLPEEKRKPLLSSLLRAYKRVlknRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 248 DKIGLLGIVALGGALVAPVVGRMADKGSPARGILYSILVVVASVILMMVF----PSNIWMIVFSVFIMDVGVQAMQITNI 323
Cdd:cd17320 238 QFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAallgGLSLWPLVAPLFLIFFGFGLIFPNAT 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 658545624 324 ATIYTLDESANSRINTVYMTCYFIGGALGTVLGVNCWHYGGWNFVLIQFMVLLVAAVCI 382
Cdd:cd17320 318 SLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLL 376
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
31-384 |
9.75e-13 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 68.99 E-value: 9.75e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 31 VQPILDEVSKSLHKSENEVGLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVLVLALFGMALIHNLYGIYLMSLII 110
Cdd:cd06174 15 ISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 111 GAMGAAAQVVMPMAAT--LATENKGKIVGMVFTGLLSGILLARVVSGY--SARLWGWQSIYMISAFVIMIMMVLVYFTLP 186
Cdd:cd06174 95 GLGSGLIDPAVLALIAdlFPERERGRALGLLQAFGSVGGILGPLLGGIlaSSLGFGWRAVFLIAAALALLAAILLLLVVP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 187 NVGTQFSGTYGELLKSTIAQ----YKRFPKLRRLSIIGALVFGVFCSFWTTITFHLTGEPFFLKSDKIGLLGIVALGGAL 262
Cdd:cd06174 175 DPPESARAKNEEASSKSVLKllkrVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGAL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 263 VAPVVGRMADKGSPARGILYSILVVVASVILMMVFPSNIWMIVFSVFIMDVGVQAMQITNIATIYTLDESAN-SRINTVY 341
Cdd:cd06174 255 GSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIrGTAFGLL 334
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 658545624 342 MTCYFIGGALGTVL-GVNCWHYGGWNFVLIQFMVLLVAAVCIAV 384
Cdd:cd06174 335 NTFGFLGGAIGPLLaGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
33-355 |
5.84e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 66.42 E-value: 5.84e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 33 PILDEVSKSLHKSENEVGLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVLVLALFGMALIHNLYGIYLMSLIIGA 112
Cdd:COG0738 29 PLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 113 MGAAAQVVM-PMAATLATENKGKI---------VGMVFTGLLSGILLARVVSgysarlWGWQSIYMISAFVIMIMMVLVY 182
Cdd:COG0738 109 GLGLLDVAAnPYVAALGPETAASRlnllhaffsLGALLGPLLGGLLILLGLS------LSWHLPYLILAVLLLLLALLFL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 183 FT-LPNVGTQFSGTYGEllKSTIAQYKRFPKLRRLSIIGALVFGVFCSFWTTITFHLTGEPFFLKSDKIGLLGIVALGGA 261
Cdd:COG0738 183 RSkLPEIEEEEEEAAGS--AASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMT 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 262 LVAPVVGRMADKGSPARGILYSILVVVASvILMMVFPSNIWMIVFSVFIMDVGVQAMQITNI-ATIYTLDESANSRINTV 340
Cdd:COG0738 261 IGRFLGGFLLKRFGPVRLLRLSALLAAVG-LLLALLAPGPWLALIGLALVGLGLSLMFPTIFsLALDGLGKRTAAAVSAV 339
|
330
....*....|....*
gi 658545624 341 yMTCYFIGGALGTVL 355
Cdd:COG0738 340 -LIMGIVGGAIGPPL 353
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
14-188 |
1.54e-10 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 62.21 E-value: 1.54e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 14 ILIMAITAGVSVASLYYVqPILDEVSKSLHKSENEVGLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVLVLALFG 93
Cdd:cd17323 2 FIISFLTFVVTFGSSIYS-PALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 94 MALIHNLYGIYLMSLIIGAMGAAAQVVMpmAATLA----TENKGKIVGMVFTGLLSGILLARVVSGYSARLWGWQSIYMI 169
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIG--AGTIAdlftPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWF 158
|
170
....*....|....*....
gi 658545624 170 SAFVIMIMMVLVYFTLPNV 188
Cdd:cd17323 159 LAIISGFCLILIFLFLPIV 177
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
71-380 |
6.36e-09 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 57.27 E-value: 6.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 71 GDKMNRKKLILLMLFVLVLALFGMALIHNLYGIYLMSLIIGAMGAAAQVVMPMAATLATENK-GKIVGMVFTGLLSGILL 149
Cdd:cd17391 60 ADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYVPNATALIASQTPKEKsGWALGTLSTGVVAGTLI 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 150 ARVVSGYSARLWGWQSIYMISAFVIMIMMVLVYFTLPNVGTQFSGTYGELLKSTIAQYKRFPKLRRLSIIGALVFGVFCS 229
Cdd:cd17391 140 GPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKEDFKPVEKKKMVSTKEVWNSVPNPSLLISLFVTTFIIQLANQS 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 230 FWTTITF---HLTGEPFFLKSDKIGLLGIVALGGALVAPVVGRMADKGSPARGILYSILVVVASVILMMvFPSNIWMIVF 306
Cdd:cd17391 220 IEPILTLyirQLMGDASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQA-FVQTPWQLGI 298
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 658545624 307 SVFIMDVGVQAM--QITNIATIYTLDESAnSRINTVYMTCYFIGGALGTVLGVN-CWHYG-GWNFVLIQFMVLLVAAV 380
Cdd:cd17391 299 LRFLLGLATGGLlpAINSLLAKITPKEVA-GRIFGYNQSFQYLGNVAGPLLGSAiAAHFGyRAVFVVTALLVLLNAIW 375
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
48-320 |
1.06e-08 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 56.44 E-value: 1.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 48 EVGLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVLVLALFGMALIHNLYGIYLMSLIIG-AMGAAaqvvMPMAAT 126
Cdd:cd17365 35 QLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGlGLGAA----MPNAIT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 127 LATE-----NKGKIVGMVFTGLLSGILLARVVSGYSARLWGWQSIYMISAFVIMIMMVLVYFTLPNVGTQFSGtygellk 201
Cdd:cd17365 111 LVSEyaparRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLRGTLLLWVTFFMG------- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 202 stiaqykrfpklrrlsiigaLVFGVFCSFWTTITFHLTGEPFflkSDKIGLLGIVALGGALVAPVVGRMADKGSPARGIL 281
Cdd:cd17365 184 --------------------LLLVYLLNSWLPKLMVEAGYSL---SQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLA 240
|
250 260 270
....*....|....*....|....*....|....*....
gi 658545624 282 YSILVVVASVILMMVFPSNIWMIVFSVFIMDVGVQAMQI 320
Cdd:cd17365 241 LFFALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQV 279
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
45-384 |
1.27e-08 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 56.13 E-value: 1.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 45 SENEVGLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVLVLALFGMALIHNLYGIYLMSLIIGA---MGAAAQVVM 121
Cdd:cd17312 36 SKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLfqsMGWPPCVKL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 122 pMAATLATENKGKIVGMVFTGLLSGILLARVVSGYSARLWGWQSIYMISAFVIMIMMVLVYFTLPNvgtqfsgtygellk 201
Cdd:cd17312 116 -LGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRD-------------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 202 stiaqykRFPKLRRLSIIGALVFGVFCSFWTTITFHLTGEPFFLKSDKIGLLGIVALGGALVAPVVGRMADKGSPAR--- 278
Cdd:cd17312 181 -------SPPYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRrap 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 279 GILYSILVVVASVILMMVFPSNIWMIVFSVFIMD--VGVQAMQITNIATIYTLDESANSRINTVYMTCYFIGGAL-GTVL 355
Cdd:cd17312 254 IAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGffVGGPINLIGGAAAQDIGRKEAAGTATGFVGLFGYLGASLaGLPL 333
|
330 340
....*....|....*....|....*....
gi 658545624 356 GVNCWHYGGWNFvliqFMVLLVAAVCIAV 384
Cdd:cd17312 334 GYIIDHYGWSTV----FYFLISAALLSVL 358
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
10-291 |
1.45e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 55.59 E-value: 1.45e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 10 SRLQILIMAITAGVSVASLYYVQPILDEVSKSLHKSENEVGLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVLVL 89
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 90 ALFGMALIHNLYGIYLMSLIIGAMGAAAQ-VVMPMAATLATENK-GKIVGMVFTGLLSGILLARVVSGYSARLWGWQSIY 167
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMpGALALIAELFPARErGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 168 MISAFVIMIMMVLVYFTLPNVGTQFSGTYGELLKSTIAQYKRFPKLRRLSIIGALVFGVFCSFWTTITFHLTGEPFFLKS 247
Cdd:COG0477 172 LINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALL 251
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 658545624 248 DKIGLLGIVALGGALVAPVVGRMADKGSPARGILYSILVVVASV 291
Cdd:COG0477 252 LLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
40-356 |
1.55e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 56.06 E-value: 1.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 40 KSLHKSENEVGLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVLVLALFGMALIHNLYGIYLMSLIIGA-MGAAAQ 118
Cdd:cd17489 24 HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIgWGAFTT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 119 VVMPMAATLA-TENKGKIVGMVFTGLLSGILLARVVSGYSARLWGWQSIYMISAFVIMIMMVLVYFTLPNVGTQFSGTYG 197
Cdd:cd17489 104 AAATLVADIIpPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 198 ELLKSTIAqykRFPKLRRLSIIGALVFGVFCSFWTTITFHLTGEPFflksDKIGL-LGIVALGGALVAPVVGRMADKGSP 276
Cdd:cd17489 184 GTRAFRRL---VEKKVLPPALILFLASIAYGAISTFLPLYAAERGI----SNAGLfFTVYAIALLLSRPFSGKLSDRKGP 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 277 ARgILYSILVVVASVILMMVFPSNIWMIVFSVFIMDVGVQAMQitNIATIYTLDESANSRINTVyMTCYFIGGALGTVLG 356
Cdd:cd17489 257 KT-VIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLF--PALQALAVDLVPPHRRGAA-NGTFFIFFDLGIGLG 332
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
49-383 |
1.58e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 56.08 E-value: 1.58e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 49 VGLLPALAQAGYGLGLFFITPYGDKMNRKKL-----ILLMLFVLVLALFGMALIHNLYGIYLMSLIIGAMGAAAQVVMP- 122
Cdd:cd06173 36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQa 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 123 -MAATLATENKGKIVGMVFTGLLSGILLARVVSGYSARLWGWQSIYMISAFVIMIMMVLVYF---TLPNVGTQFSGTYGE 198
Cdd:cd06173 116 lLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFirrPPPAAPGESSSLLLR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 199 LLKSTIAQYKRFPKLRRLSIIGALVFGVFCSFWTTI------TFHLTGEPFFLksdkigLLGIVALGGALVAPVVGRMAD 272
Cdd:cd06173 196 DLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLpllakeVLGGGAAGYGL------LLAAFGVGALLGALLLGRLSK 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 273 KGSPARGILYSILVVVASVILmMVFPSNIWMIVFSVFIMDVGVQAMQITNIATIYTL-DESANSRINTVYMTCYFIGGAL 351
Cdd:cd06173 270 RRRRGRLLLIGALLLGLALLV-LGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRvPDELRGRVFSVYNALNSGAMPL 348
|
330 340 350
....*....|....*....|....*....|..
gi 658545624 352 GTVLGVNCWHYGGWNFVLIQFMVLLVAAVCIA 383
Cdd:cd06173 349 GALLAGLLADALGLSAVFLLAGALLLLAALLL 380
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
45-356 |
3.87e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 54.49 E-value: 3.87e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 45 SENEVGLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVLVLALFGMALIHNLYGIYLMSLIIGAMGAAAQVVMP-- 122
Cdd:cd17477 29 STALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSEsw 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 123 MAATLATENKGKIVG---MVFT-GLLSGILLARVVSGYSARLwgwqsiYMISAFVIMIMMVLVYFTLPNVGTQFSGTYGE 198
Cdd:cd17477 109 LNALATNENRGRVLGlysTVLGlGFALGPLLLALVGTAGALP------FLIAAVLLLLALVPLLLTRRAAPEIEEAESIS 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 199 LLkstiaqykRFPKLRRLSIIGALVFGVF-CSFWTTITFHLTGEPFFLkSDKIGLLGIVALGGALVAPVVGRMADKGSPA 277
Cdd:cd17477 183 LR--------RLLRIAPLALLGAFVAGFLeGAFYSLLPLYGLRLGLSV-AQAALLLAAFVLGGLLLQWPLGWLADRFDRR 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 278 RGILYSILVVVASVILMMVFPSNIWMIVFSVFIMDVGVQAMQITNIATIY-TLDESANSRINTVYMTCYFIGGALGTVLG 356
Cdd:cd17477 254 RVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGdRLPGDELVAANAALLLLYGLGSVIGPLLA 333
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
18-385 |
4.97e-08 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 54.58 E-value: 4.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 18 AITAGVSVASLYYVQPILDEVSKSLHKSENEVGLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVLVLALFGMALI 97
Cdd:cd17355 9 FLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 98 HNLYGIYLMSLIIGAMGAAAqVVMPMAATLAT----ENKGKIVGMVFTGLLSGILLARVVSGYSARLWGWQSIYMISAFV 173
Cdd:cd17355 89 TSLWQLYLLWGLLGGGGAGT-LAAVAFATVAAwwfeRRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 174 IMIMMVLVYFTL-----PNVGTQFSGTYGELLKSTIAQYKRFPKLRRLSIIGALVfGVFCSFWTTITFHLTGEPFFLKSD 248
Cdd:cd17355 168 ALLVLVPVLLLLrrrpaDLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLC-GFAVVGLIVHLVPYLADRGISPAA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 249 KIGLLGIVALGGALVAPVVGRMADKGSPAR-GILYSILVVVASVILMMVFPSNIWMIVFSVFI--MDVGVQAMQITNIAT 325
Cdd:cd17355 247 AAVALALIGLFNIVGRLLSGWLGDRYSPRRlLAASYALRALGLALLLLLPFPPLALLLFAALFglGWGATVPLTAALAAR 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 658545624 326 IYTLDESAnSRINTVYMTcYFIGGALG-TVLGVNCWHYGGWNFVLIQFMVLLVAAVCIAVV 385
Cdd:cd17355 327 YFGARSYG-TLFGLVFAP-HQLGSALGpWLGGLLYDRTGSYTAAWALAVALGLIAALLVLP 385
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
48-384 |
1.39e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 52.99 E-value: 1.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 48 EVGLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVLVLALFGMALIHNLYGIYLMSLIIG-AMGAAAQVVMPMAAT 126
Cdd:cd17316 37 QTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGiGIGGEYPGASTYVAE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 127 LA-TENKGKIVGMVFT----GLLSGILLARVVSGYSARLWGWQSIYMISAFVIMIMMVLVYFTLPNVGtqfsgtygellk 201
Cdd:cd17316 117 FApSKRRGFALGLLQSgwalGALLAALVASLLIPLLSGDWGWRILFLIGALPALLALLLRRRTLLLIL------------ 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 202 stiaqykrfpklrrLSIIGALVFGVFCSFWTTITFHLTGepfFLKSDKIGLLGIVALGGALVAPVVGRMADK-GSPARGI 280
Cdd:cd17316 185 --------------LWFFISFGYYGLTTFLPTYLQTVLG---LSPATSSLYLLLISLGALVGALIAGLLSDRiGRKKTLV 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 281 LYSILVVVASVILMMVFPSNIWMIVFSVFIMDVGVQAMQITNIATIYTL--DESANSRINTVYMTCYFIGGALGTVLGVN 358
Cdd:cd17316 248 IGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELfpTEVRATGVGLSYNLGRLGGGGAPPLIALL 327
|
330 340
....*....|....*....|....*.
gi 658545624 359 CWHYGGWNFVLIQFMVLLVAAVCIAV 384
Cdd:cd17316 328 LASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
73-306 |
3.86e-07 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 51.78 E-value: 3.86e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 73 KMNRKKLILLMLFVLVLALFGMALIHNLYGIYLMSLIIGAMGAAAqvvMP----MAATLATENKGKIVGMVFTGLLSGIL 148
Cdd:cd17471 59 GGDRKPLILLALLAGALGYLLFAFLRNYWVLLLVGVVLLSLGAAA---FPqlfaLAREYADRSSGRDATLFNSVLRAAFS 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 149 LARVV----SGYSARLWGWQSIYMISAFVIMIMMVLVYFTLPNVGTQfsgtygeLLKSTIAQYKRFPKLRRLSIigaLVF 224
Cdd:cd17471 136 LAWVIgpplAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPP-------AQKATPASSLVKAPVNRRLL---LLF 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 225 GVFCSFWTTITFHLTGEPFFLKSDKIG-------LLGIVALGGALVAPVVGRMADKGSPARGILYSILVVVASVILMMVF 297
Cdd:cd17471 206 AAFTLLFAANSMYIIAMPLYVTNELGGseswvglLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALA 285
|
....*....
gi 658545624 298 PSnIWMIVF 306
Cdd:cd17471 286 TS-LWQLIA 293
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
12-183 |
3.93e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 51.46 E-value: 3.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 12 LQILIMAITAGVSVASLYYVQpildevsKSLHKSENEVGLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVLVLAL 91
Cdd:cd06173 216 ALALFALLGGALTVLLPLLAK-------EVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLAL 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 92 FGMALIHNLYGIYLMSLIIGAMGAAAQVVMP--MAATLATENKGKIVGMVFTGLLSGILLARVVSGYSARLWGWQSIYMI 169
Cdd:cd06173 289 LVLGLSPSLWLLLAALFLLGLAGGLFNVPLNtlLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLL 368
|
170
....*....|....
gi 658545624 170 SAFVIMIMMVLVYF 183
Cdd:cd06173 369 AGALLLLAALLLLL 382
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
34-385 |
5.71e-07 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 51.03 E-value: 5.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 34 ILDEVSKSLHKSENEVGLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVLVLALFGMALIHNLYGIYLMSLIIGAM 113
Cdd:cd17319 25 AAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 114 GAAAqvvMPMAATLATEN-----KGKIVGMVFTGLLSGILLARVVSGYSARLWGWQSIYMISAFVIMIMMVLVYFTLPNV 188
Cdd:cd17319 105 EAGF---FPGAIKALAEWfpareRGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQV 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 189 gtqfsgtygellkstiaqykrfpklrrlsiiGALVFGVFCSFWTTITFhLTGEPFFLKS------DKIGLLGIV-ALGGA 261
Cdd:cd17319 182 -------------------------------WGLALGYFGINYALYGL-LTWLPTYLKQargfslKQVGLLAAIpFLAGA 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 262 LVAPVVGRMADKGSP--ARGILYSILVVVASVILMMVFPSNIWMIVFSVFIMDVGVQAMQITNIATIYT-LDESANSRIN 338
Cdd:cd17319 230 IGMILGGRLSDRLLRgaRRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADlLPGEAAATAG 309
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 658545624 339 TVYMTCYFIGGALG-TVLGVNCWHYGGWNFVLIQFMVLLVAAVCIAVV 385
Cdd:cd17319 310 GLINSGGNLGGFVApLLIGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
71-356 |
6.50e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 51.04 E-value: 6.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 71 GDKMNRKKLILLMLFVLVLALFGMALIHNLYGIYLMSLIIGAMGAaaqvVMPMAATLATENKGKIVGMVFTGLLSGIL-- 148
Cdd:cd17504 55 GDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGA----VFPLAFALVREEFPPERVPVAQGILSATFgi 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 149 ---LARVVSGYSARLWGWQSIYMISAFVIMIMMVLV------YFTLPNVGTqfsgtygellkstiaqykrfpklrrLSII 219
Cdd:cd17504 131 gagIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVplidlrLLRRRNVLL-------------------------ANIT 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 220 GALV-FGVFCSFWTTITFHLTGEP--FFLKSDKIGLLGI-VALGGALVAPVVGRMADKGSPARGILYSILVVVASVILMM 295
Cdd:cd17504 186 ALLAgFGMFMVFQLLPQLLQLPTPtgFGLGITEAGLLLLpGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLA 265
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 658545624 296 VFPSNIWMIVFSVFIMDVGVQAMQITNIATI-YTLDESANSRINTVYMTCYFIGGALGTVLG 356
Cdd:cd17504 266 LLHSSLWALVVALLLIGIGLGLAFASLPNIVvESVPPDRTGIATGMNTVLRTIGSAIGPAIA 327
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
75-306 |
1.11e-06 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 50.30 E-value: 1.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 75 NRKKLILLMLFVLVLALFGMALIHNLYGIYLMSLIIGAMGAAAQVVMPM-AATLATENKGKIVGMVFTGLLSGILLARVV 153
Cdd:cd17490 60 KRKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWVSFTVLyASYFPPDEAAKAMGLINLVNNLGQLIAFLI 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 154 SGYSARLWGWQSIYMISAFVIMIMMVLVYF----TLPNVGTQFSgtygelLKSTIAQYKRfPKLRRLSIIGALVFGVfcS 229
Cdd:cd17490 140 GGLIAEHFGMRAPFLLAALAGVLGFILSLFikeeRREKKPVLTE------LKELLSVLKD-KKLLFFSLLAILQQMI--T 210
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 658545624 230 FWTTITF-HLTGEPFFLKSDKIGLLGIVALG-GALVAPVVGRMADKGSPARGILYSILVVVASVILMMVFPSNIWMIVF 306
Cdd:cd17490 211 FSTTFGFtPLIAKQLGASSFQLGLLSIIYLLpNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYL 289
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
1-186 |
2.08e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 49.28 E-value: 2.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 1 MENSMQKGLSRLQILIMAITA------GVSVASLYYVQPILdevSKSLHKSENEVGLLPALAQAGYGLGLFFITPYGDKM 74
Cdd:TIGR00895 3 QNNIRKQPLSRYQWRAIILSFlimlmdGYDLAAMGFAAPAI---SAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 75 NRKKLILLMLFVLVLALFGMALIHNL--YGIY--LMSLIIGAMGAAAQVVMPMAAtlATENKGKIVGMVFTGLLSGILLA 150
Cdd:TIGR00895 80 GRRRVLLWSILLFSVFTLLCALATNVtqLLILrfLAGLGLGGLMPNLNALVSEYA--PKRFRGTAVGLMFCGYPIGAAVG 157
|
170 180 190
....*....|....*....|....*....|....*.
gi 658545624 151 RVVSGYSARLWGWQSIYMISAFVIMIMMVLVYFTLP 186
Cdd:TIGR00895 158 GFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLP 193
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
55-309 |
3.11e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 48.71 E-value: 3.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 55 LAQAGYGLGLFFITP---------YGDKMNRKKLILLMLFVLVLALFGMALIHNLYGIyLMSLIIGAMGAAA--QVVMPM 123
Cdd:cd17478 30 YAQAGLLVSVFSITSsllqplfgyLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLL-LLLVALAGIGSAAfhPEGARL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 124 AATLATENKGKIVGMVFTGLLSGILLARVVSGYSARLWGWQSIYMISAFVImIMMVLVYFTLPNVGTQFSGTYGELLKST 203
Cdd:cd17478 109 ASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPG-LAVALLLLRLRPLKKPEAKKAAAKSSAR 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 204 IAQYKRFPKLRRLSIIGALVFGVFCSFWTTITFHLTGEpFFLKSDKIGLLGIVALGGALVAPVVGRMADKGSPARGILYS 283
Cdd:cd17478 188 STLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQR-GYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIAS 266
|
250 260
....*....|....*....|....*.
gi 658545624 284 ILVVVASVILMMVFPSNIWMIVFSVF 309
Cdd:cd17478 267 LLLAAPFLLLFLLTPGIWSYILLVLA 292
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
38-380 |
3.93e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 48.38 E-value: 3.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 38 VSKSLHKSENEVGLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVLVLALFGMALIHNLYGIYLMSLIIGAMGAAA 117
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 118 QVVM-PMAATLAT-ENKGKIVGMVFTGLLSGILLARVVSGYSARLwGWQSIYMISAFVIMIMMVLVYFTLPNVGTQFSGT 195
Cdd:cd17329 106 EPASeAMIADVTTpENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 196 YGELLKSTIAQYKRFPKLRRLSIIGALVFGVFCSFWTTITFHLTGEPFFLKSDKIGLLGIVALGGALVAPVVGRMADKGS 275
Cdd:cd17329 185 EKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFR 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 276 PARGILYSILVVVASvILMMVFPSNIWMIVFSVFIMDVG------VQAMQITNIAtiytlDESANSRINTVYMTCYFIGG 349
Cdd:cd17329 265 LRKILMIGILLFAIG-FAVLAFANTLAVLILAMIVLTLGemlvfpAVQTLVAALA-----PPDKRGSYMGFYALAWGLGR 338
|
330 340 350
....*....|....*....|....*....|...
gi 658545624 350 ALGTVLGVNC--WHYGGWNFVLIQFMVLLVAAV 380
Cdd:cd17329 339 AIGPLVGGLLldLLGPGLPWLILAALGLIAAAL 371
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
58-186 |
4.32e-06 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 48.37 E-value: 4.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 58 AGYGLGLFFITPYGDKMNRKKLILLMLFVLVLALFGMALIHNLYGIYLMSLIIGAMGAAAQVVMP--MAATLATENKGKI 135
Cdd:PRK11102 37 LGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAASVVINalMRDMFPKEEFSRM 116
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 658545624 136 vgMVFTGLLSGI--LLARVVSGYSARLWGWQSIYMISAFVIMIMMVLVYFTLP 186
Cdd:PRK11102 117 --MSFVTLVMTIapLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIP 167
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
33-385 |
8.63e-06 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 47.30 E-value: 8.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 33 PILDEVSKSLHKSENEVGLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVLVLALFGMALIHNLYGIYLMSLIIGA 112
Cdd:cd06180 20 PLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 113 MGAAAQVVMP--MAATLATENKGKIVGMVFTGLLSGILLARV-VSGYSARLWGWQSIYMISAFVIMIMMVLVYFTLPNVg 189
Cdd:cd06180 100 ASAFVFVFGSnlVLHHATAAGRGHLIGLLFAGVGLGIALSGLlVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRG- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 190 tqfSGTYGELLKSTIAQYKRFPKLRRLSIIGALVFGvfcsFWTTITFHltgePFFLKSDKIG------LLGIVALGGALV 263
Cdd:cd06180 179 ---PSAPTEASAAESAPGLNRPLWRLALAYGLFGFG----YIITATFL----PLIARETGAGsllaglLWSLFGLAAVPS 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 264 APVVGRMADKGSPARGILYSILVVVASVILMMVFPSNIWMIVFSVFimdVGVQAMQITNIATIYTLDESANSRINTV-YM 342
Cdd:cd06180 248 CFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSPGPAGLVLSAVL---FGGTFMAITALVMALARELAPPAAPRALaLM 324
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 658545624 343 TCYF-IGGALGTVL-GVNCWHYGGWNFVLIQFMVLLVAAVCIAVV 385
Cdd:cd06180 325 TASFgVGQILGPLLaGWLADATGGFAPALILAAAALVVAALLALL 369
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
76-326 |
1.01e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.20 E-value: 1.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 76 RKKLILLMLFVLVLALFGMALIHNL---------YGIYLMSLIIGAMGAAAQVVMPMAATLATENKGKIVGMVFTGLLSG 146
Cdd:COG2211 80 RRPWILIGAIPLALSFVLLFTAPDLsptgkliyaLVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLG 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 147 ILLARVVSGYSARLW------GWQSIYMISAFVIMIMMVLVYFTLP--NVGTQFSGTYGELLKSTiaqyKRFPKLRRLSI 218
Cdd:COG2211 160 GLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKerPVPEEEKVSLKESLKAL----LKNRPFLLLLL 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 219 IGALVFGVFCSFWTTITFHLTgepFFLKSDKI---GLLGIVALGGALVAPVVGRMADKGSPARGILYSILVVVASVILMM 295
Cdd:COG2211 236 AYLLFFLALALVAALLLYYFK---YVLGLSAAlvgLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLF 312
|
250 260 270
....*....|....*....|....*....|..
gi 658545624 296 VF-PSNIWMIVFSVFIMDVGVQAMQITNIATI 326
Cdd:COG2211 313 FLgPGNLWLLLVLAALAGIGLGAILVLPWAML 344
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
71-367 |
1.16e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 47.19 E-value: 1.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 71 GDKMNRKKLILLMLFVLVLALFGMALIHNLyGIYLMSLIIGAMGAAAQVVMPMAATLAT---ENKGKIVGMVFTGLLSGI 147
Cdd:cd17503 55 ADRFGTRRLFLTALALFTLGSLLCGLAPNL-ASLIIFRILQGFGGGVLIPLAQTILLRIyppEKRGAAMGLVGLVILLAP 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 148 LLARVVSGYSARLWGWQSIymisaFVIMIMMVLVYFTLpnvgtqfsgtyGELLKSTIAQYKRFpklrRLSIIGALVFGvF 227
Cdd:cd17503 134 AIGPTLGGWLTDNLSWRWI-----FYINLPIGILALLL-----------APLLDLRLFKDRNF----TLGLLLSFLLG-L 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 228 CSFWTTITFHL-TGEPFFLKSDKIGLLGI-VALGGALVAPVVGRMADKGSPARGILYSILVVVASVILMMVF--PSNIWM 303
Cdd:cd17503 193 GLFGAMFLLPLyLQNVLGYSAFESGLVLApGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLtpDTSLWL 272
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 658545624 304 IVFSVFIMDVGvQAMQITNIATIY--TLDESANSRINTVYMTCYFIGGALGTVLGVNCWHYGGWNF 367
Cdd:cd17503 273 IILPLFIRGLG-MGLVFMPLNTLAlnSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRTQFH 337
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
12-320 |
1.22e-05 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 46.81 E-value: 1.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 12 LQILIMAITAGVSVASLYYVQPILDEVSKSLHKSENEVGLLP---ALAQAGYGLGLFFITpygDKMNRKKLiLLMLFVLV 88
Cdd:PRK03545 9 LRVVTLALAAFIFNTTEFVPVGLLSDIAQSFHMQTAQVGLMLtiyAWVVALMSLPLMLLT---SNVERRKL-LIGLFVLF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 89 LALFGMALIHNLYGIYLMSLIIGAMGAAA--QVVMPMAATLATENKG-KIVGMVFTG----LLSGILLARVVSGYsarlW 161
Cdd:PRK03545 85 IASHVLSALAWNFTVLLISRIGIAFAHAIfwSITASLAIRVAPAGKKaQALSLLATGtalaMVLGLPLGRVIGQY----L 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 162 GWQSIYMISAFVIMIMMVLVYFTLPNVGTQFSGTygelLKSTIAQYKRfPKLRRLSIIGALVfgvfcsfwttITFHLTG- 240
Cdd:PRK03545 161 GWRTTFLAIGGGALITLLLLIKLLPLLPSEHSGS----LKSLPLLFRR-PALVSLYLLTVVV----------VTAHFTAy 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 241 ---EPFFLK----SDKIGLLGIVALGGA-LVAPVV-GRMADKGsPARGILYSILVVVASVILMMVFPSNIW-MIVFSVF- 309
Cdd:PRK03545 226 syiEPFVQQvaglSENFATLLLLLFGGAgIIGSVLfSRLGNRH-PSGFLLIAIALLLVCLLLLLPAANSEWhLSVLSIFw 304
|
330
....*....|....
gi 658545624 310 ---IMDVGVqAMQI 320
Cdd:PRK03545 305 giaIMCIGL-AMQV 317
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
71-355 |
1.32e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 46.78 E-value: 1.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 71 GDKMNRKKLILLMLFVLVLALFGMALIHNLygiylMSLIIG--AMGAAAQVVMP-----MAATLATENKGKIVGMVFTGL 143
Cdd:cd17321 55 GDRFGRKRVFLIGLALFGLASLLCALAPSL-----AFLIAAraLQGIGAAAIMPaslalIAATFPGERRGRALGLWGAVV 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 144 LSGILLARVVSGYSARLWGWQSIYMISAFVIMIMMVLvyftlpnvGTQFSGTygellkstiaqykrfpklrrlSIIGALV 223
Cdd:cd17321 130 GIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLL--------ARTFSGA---------------------VLAAFLL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 224 FGVFCSFWTTITFHLTGEpFFLKSDKIGLLGI-VALGGALVAPVVGRMADKGSPARGILYSILVVVASVILMMVFPSN-- 300
Cdd:cd17321 181 GAALGGLLFLLPLYLQGV-LGYSPLQAGLALLpLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADss 259
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 658545624 301 IWMIVFSVFIMDVGVQ-AMQITNIATIYTLDESANSRINTVYMTCYFIGGALGTVL 355
Cdd:cd17321 260 VWLLLPGLVLLGLGLGlFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVAL 315
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
8-186 |
2.15e-05 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 46.05 E-value: 2.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 8 GLSRLQILIMAITAGVSVASLYYVqPILDEVSKSLHKSENEVGLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVL 87
Cdd:PRK11652 5 RNVNLLFMLVLLVAVGQMAQTIYV-PAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 88 VLALFGMALIHNLYGIYLMSLIIGAMGAAAQVvmpMAATL-----ATENKGKIVGMVFTGLLSGILLARVVSGYSARLWG 162
Cdd:PRK11652 84 ILGTLVALFAHSLTVLIAASAIQGLGTGVGGV---MARTLprdlyEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFG 160
|
170 180
....*....|....*....|....*...
gi 658545624 163 WQSIY----MISAFVIMIMMVLVYFTLP 186
Cdd:PRK11652 161 WRACYlfllLLGAGVTFSMARWMPETRP 188
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
42-382 |
4.20e-05 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 45.31 E-value: 4.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 42 LHKSENEVGLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVLVLALFGMALIHNLYGIYLMSLIIGAMGAAAQvvm 121
Cdd:cd17475 26 LHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQ--- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 122 pMAATLAT------ENKGKIVGMVFTGLLSGILLARVVSGYSARLWGWQSIYMISAFVIMIMMVLVYFTLPN-VGTQFSG 194
Cdd:cd17475 103 -PGGGRAImrwfppRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREpPAASAAT 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 195 TYGELLKSTIAQYKRFPKLRRLSIIGALVfgvfCSFWTTITFHLTgePFFLKSDKIG------LLGIVALGGALVAPVVG 268
Cdd:cd17475 182 ESASTLLRSLKEVLRNRDVWLIAIAGALL----VAPQFALLTFLL--LFLHDHLGLSvvaagaLLAVAQLGGALGRIGLG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 269 RMADK--GSPARGILYSILVVVASVILMMVFPSNIWMIVFSVFIMDV-GVQAMQITNIATIYTLDESANSRINTVY---M 342
Cdd:cd17475 256 RVSDRvfGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILlGLFAIGWNGLYLTLVAESAGPEQAGTALglaN 335
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 658545624 343 TCYFIGGALGTVL-GVNCWHYGGWNFVLIQFMVLLVAAVCI 382
Cdd:cd17475 336 TINFIGIAIGPPLfGLLVDATHSYAPAWLALALLLVLAALL 376
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
12-183 |
5.34e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 44.87 E-value: 5.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 12 LQILIMAITAGVSVASLYYVQPILdeVSKSLHKSENEVGLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVLVLAL 91
Cdd:cd17325 202 LALFLAIFVLAFAFGALEPFLPLY--AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 92 FGMALIHNLYGIYLMSLIIGAMGAAAQV-VMPMAATLATENK-GKIVGMVFTGLLSGILLARVVSGYSARLWGWQSIYMI 169
Cdd:cd17325 280 LLLPLATSFWLLLLLLALLGLGLGLVFPaTLALLADIVPPEGrGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLA 359
|
170
....*....|....
gi 658545624 170 SAFVIMIMMVLVYF 183
Cdd:cd17325 360 AAALLLLAAVLFLL 373
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
14-385 |
7.09e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 44.49 E-value: 7.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 14 ILIMAITAGVSVAslyyvqPILDEVSKSLHK-SENEVGLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVLVLALF 92
Cdd:cd17473 7 ASTLTVMAGAAIA------PALPAIAQHFVPnSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 93 GMALIHNLYGIYLMSLIigaMGAAAQVVMPMAATLAT-----ENKGKIVG--MVFTGLLSGILLArvVSGYSARLwGWQS 165
Cdd:cd17473 81 AGLFLDSLYALLASRAL---LGIGVAGIMTLATALIGdyfegEERAKMLGlqSAAMSLGGVVFLL--LGGALAEI-GWRA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 166 IYMISAFVImIMMVLVYFTLPNVGTQFSGTygellKSTIAQYKRFPKLRRLSIIGALVFGVFCSFWTTITFHltgePFFL 245
Cdd:cd17473 155 PFLVYLLAL-PVLILVLLFLPEPARKSKSA-----ASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQL----PFLL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 246 KSDKIG-------LLGIVALGGALVAPVVGRMADKGSPARGILYSILVVVASVILMMVFPSNIWMIVFSVFIMDVGVQAM 318
Cdd:cd17473 225 QERGGGsaaliglALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLL 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 658545624 319 QITNIATIYTLDESANSRINTVYMTCYFIGGALGTVLgvncWHYGGWNFVLIQFMVLLVAAVCIAVV 385
Cdd:cd17473 305 PTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLV----LGPLVNLTGGLSGAFLILGVLALVLA 367
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
43-310 |
7.71e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 44.49 E-value: 7.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 43 HKSENEVGLLPALAQAGYGLGLFFITPY----GDKMNRKKLILLMLFVLVLALFGMALIHNLYGIYLMSLIIGAMGAAAQ 118
Cdd:cd17330 26 FNKLGASGYYVGLLQSSYSLGQFLASPLwgrlSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 119 VVMPMAATLATENKgKIVGMVFTGLLSGI--LLARVVSGYSARLWGWQSIYMISAFVIMIMMVLVYFTLPNvgtqfsgty 196
Cdd:cd17330 106 VAQAYIADITDEEE-RAKAFGIISAAFGLgfILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPP--------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 197 gellkstiaqykrfpkLRRLSIIGALVFGVFCSFWTTITFHLTGEPFFLKSDKIGLLGIVALGGALV-APVVGRMADKGS 275
Cdd:cd17330 176 ----------------LRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAqLLLIPRLAKRLG 239
|
250 260 270
....*....|....*....|....*....|....*
gi 658545624 276 PARGILYSILVVVASVILMMVFPSNIWMIVFSVFI 310
Cdd:cd17330 240 ERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAIL 274
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
40-305 |
8.17e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 44.23 E-value: 8.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 40 KSLHKSENEVGLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVLVLALFGMALIHNLYGIYLMSLIIG-AMGAAAQ 118
Cdd:cd17333 24 EAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGlGAGILDT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 119 VVMPMAATLATENKGKIVGMVFTGLLSGILLARVVSGYS-ARLWGWQSIYMISAFVIMIMMVLVYFTL--PNVGTQFSGT 195
Cdd:cd17333 104 GANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLlTSELSWSWAYLIIGLIYLLLAILILLTLfpELPSARNPQQ 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 196 YGELLKSTIAQYKRFPKLRRLSIIGALVFGVFCSFWTTITFHLTGEPFFLKSDKIGLLGIVALGGALVAPVVGRMADKGS 275
Cdd:cd17333 184 SVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIK 263
|
250 260 270
....*....|....*....|....*....|
gi 658545624 276 PARGILYSILVVVASVILMMVFPSNIWMIV 305
Cdd:cd17333 264 PHTLLVLSGSGALLGLLILLLAPTLVVGLV 293
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
40-186 |
4.63e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 41.78 E-value: 4.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 40 KSLHKSENEVGLLPALAQAGYGLGLFFITPYGDKMNR--KKLILLMLFVLVLALFGMALIHNLYGIYLMSLIIGAMGAAA 117
Cdd:COG2271 209 EVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGA 288
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 658545624 118 QVVMPMAAT--LATENKGKIVGMVFTGLLSGILLARVVSGYSARLWGWQSIYMISAFVIMIMMVLVYFTLP 186
Cdd:COG2271 289 FGLLWALAAelFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
40-181 |
1.21e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 40.60 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 40 KSLHKSENEVGLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVLVLALFGMALIHNLYGIYLMSLIIGAMGAAAQV 119
Cdd:cd17370 227 QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQES 306
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 658545624 120 VMP-MAATLATEN-KGKIVGMVFTGLLSGILLARVVSGYSARLWGWQSIYMISAFVIMIMMVLV 181
Cdd:cd17370 307 IERaAVADLVPAElRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
12-183 |
1.26e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 40.66 E-value: 1.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 12 LQILIMAITAGVSVASLYYVQpildevsKSLHKSENEVGLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVLVLAL 91
Cdd:COG2211 236 AYLLFFLALALVAALLLYYFK-------YVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGL 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 92 FGMALI--HNLYGIYLMSLIIGAMGAAAQVVMP-MAATLATENKGKI-----------------VGMVFTGLLSGILL-- 149
Cdd:COG2211 309 LLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWaMLADVVDYDEWKTgrrreglyfgiftfaikLGQALAGALAGLLLal 388
|
170 180 190
....*....|....*....|....*....|....*...
gi 658545624 150 ----ARVVSGYSARLWGWQSIYMISAFVIMIMMVLVYF 183
Cdd:COG2211 389 fgyvAGAAQSPSALTGIRLLFFLLPAVLLLLAALLLLF 426
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
65-180 |
2.10e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 39.92 E-value: 2.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 65 FFITPYGDKMNRKKLILLMLFVLVLALFGMALIHNLYGIYLMSLIIGAMGAAAQVV-MPMAATLATENKGKIvGMvFTGL 143
Cdd:cd17313 299 LPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININpYPLVSDYHSESGRGQ-GT-DTGL 376
|
90 100 110
....*....|....*....|....*....|....*...
gi 658545624 144 LSG-ILLARVVSGYSARLWGWQSIYMISAFVIMIMMVL 180
Cdd:cd17313 377 LNLaISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFL 414
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
38-184 |
2.14e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 39.86 E-value: 2.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 38 VSKSLHKSENEVGLLPALAQAGYGLGLFFITPY-GDKMNRKKLILLMLFVLVLALFGMALIHNLYgiyLMSLIIGAMGAA 116
Cdd:cd17474 225 LELLYGISPIIIGLLFAGWSVLLALGSLFVGRLlKKRFGARRILVIGLLLYALSLLLLGFVPSLA---LLLIAIVLFGLG 301
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 658545624 117 AQVVMPMAATLATENKGKIVGMVFTGLLS-----GILLARVVSGYSARLWGWQSIYMISAFVIMIMMVLVYFT 184
Cdd:cd17474 302 LGLNLPLLTTLVTELAPEEERGTASSLYNfvrflGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
208-387 |
3.88e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 39.08 E-value: 3.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 208 KRFPKLRRLSIIGALVFGVFCSFWTTITFHLTGEP----FFLKSDKIGLL-GIVALGGALVAPVVGRMADKGSPARGILY 282
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPlqadLGLSAAQLGLLaSAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 283 SILVVVASVILMMVFPSnIWMIVFSVFIMDVGVQAMQITNIATI-YTLDESANSRINTVYMTCYFIGGALGTVLGVNCWH 361
Cdd:COG2271 81 GLLLWGLATLLFGFATS-FWQLLLLRFLLGLGEAGFFPAALKLIaEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159
|
170 180
....*....|....*....|....*.
gi 658545624 362 YGGWNFVliqFMVLLVAAVCIAVVNI 387
Cdd:COG2271 160 AFGWRAA---FLILGLPGLLLALLRF 182
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
30-181 |
8.21e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 37.91 E-value: 8.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 30 YVQPILDEVSkslHKSENEVGLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVLVLALFGMALIHNLYGIYLMSLI 109
Cdd:cd17324 220 YLAPFLTDVP---GFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVL 296
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 658545624 110 IGAMGAAAQVVMPMAAT-LATENKGKIVGMVFTGLLSGILLARVVSGYSARLWGWQSIYMISAFVIMIMMVLV 181
Cdd:cd17324 297 WGLGFFAAHSALQTRVLrLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
50-180 |
9.23e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 38.02 E-value: 9.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658545624 50 GLLPALAQAGYGLGLFFITPYGDKMNRKKLILLMLFVLVLALFGMALIHNLYGIYLMSL--IIGAMGA-AAQVVMPM-AA 125
Cdd:pfam00083 49 GLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLIVgrVLVGIGVgGASVLAPMyIS 128
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 658545624 126 TLATENK-GKIVGMVFTGLLSGILLARVV---SGYSARLWGWQ----SIYMISAFVIMIMMVL 180
Cdd:pfam00083 129 EIAPKKLrGALGSLYQLAITFGILLAYIFglgLNKTSNSDGWRiplgLQLVPALLLIIGLLFL 191
|
|
| |
