|
Name |
Accession |
Description |
Interval |
E-value |
| murQ |
PRK05441 |
N-acetylmuramic acid-6-phosphate etherase; Reviewed |
1-297 |
2.64e-180 |
|
N-acetylmuramic acid-6-phosphate etherase; Reviewed
Pssm-ID: 235467 [Multi-domain] Cd Length: 299 Bit Score: 498.54 E-value: 2.64e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 1 MNLGSLVSETRNPQTMDLDALSTLELVNRFNQQDTLVAQAVKETLPEVAKAVDAAAEALKAGGRIIYMGAGTSGRLGVLD 80
Cdd:PRK05441 1 MMLENLTTEQRNPASMDLDQLSTLEILRLINEEDKKVALAVEKALPQIAAAVDAAAAALRQGGRLIYIGAGTSGRLGVLD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 81 ASECPPTFGVPHGLVVGLIAGGPGALLKAVEGAEDNAQLGEDDLKDLNLTAKDLVVGLAASGRTPYVIGGLEYANRTGCT 160
Cdd:PRK05441 81 ASECPPTFGVPPELVVGLIAGGEKALTKAVEGAEDDAELGAADLKAINLTAKDVVVGIAASGRTPYVIGALEYARERGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 161 TVAISCNPGSPIAQVAAIAISPVVGPEALTGSTRLKSGTAQKLVLNMISTGAMVKFGKVYQNLMVDMQATNVKLVDRACR 240
Cdd:PRK05441 161 TIGISCNPGSPLSKEADIAIEVVVGPEVLTGSTRMKAGTAQKLVLNMISTGVMIRLGKVYGNLMVDVKATNEKLVDRAVR 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 658548680 241 MVMEATGAGREEAEAVLKQTDHDVKPAILMILSGLDAAAARAKLAAHNGFLRAALEN 297
Cdd:PRK05441 241 IVMEATGVSREEAEAALEAADGSVKLAIVMILTGLDAAEAKALLARHGGFLRKALAE 297
|
|
| MurQ |
COG2103 |
N-acetylmuramic acid 6-phosphate (MurNAc-6-P) etherase [Cell wall/membrane/envelope biogenesis] ... |
1-297 |
2.88e-174 |
|
N-acetylmuramic acid 6-phosphate (MurNAc-6-P) etherase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441706 [Multi-domain] Cd Length: 301 Bit Score: 483.44 E-value: 2.88e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 1 MNLGSLVSETRNPQTMDLDALSTLELVNRFNQQDTLVAQAVKETLPEVAKAVDAAAEALKAGGRIIYMGAGTSGRLGVLD 80
Cdd:COG2103 2 MDLGKLTTEQRNPRSLDLDTLSTLEILRLINEEDAKVAAAVRAALPAIAAAVDAIAEALRAGGRLIYVGAGTSGRLGVLD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 81 ASECPPTFGVPHGLVVGLIAGGPGALLKAVEGAEDNAQLGEDDLKDLNLTAKDLVVGLAASGRTPYVIGGLEYANRTGCT 160
Cdd:COG2103 82 ASECPPTFGTPPERVVGLIAGGEEALFRAVEGAEDDEEAGAADLKALGLGPGDVVVGIAASGRTPYVIGALEYARARGAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 161 TVAISCNPGSPIAQVAAIAISPVVGPEALTGSTRLKSGTAQKLVLNMISTGAMVKFGKVYQNLMVDMQATNVKLVDRACR 240
Cdd:COG2103 162 TVAIACNPGSPLSAAADIAIELVTGPEVITGSTRLKAGTAQKLVLNMLSTAAMIRLGKVYGNLMVDVRATNAKLRDRAIR 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 658548680 241 MVMEATGAGREEAEAVLKQTDHDVKPAILMILSGLDAAAARAKLAAHNGFLRAALEN 297
Cdd:COG2103 242 IVMEATGCDEEEAEEALEAAGGHVKTAILMILTGLDAEEAEALLARAGGFLRKALAA 298
|
|
| SIS_Etherase |
cd05007 |
N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ... |
14-270 |
5.51e-140 |
|
N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid carries a unique D-lactyl ether substituent at the C3 position. The etherase catalyzes the cleavage of the lactyl ether bond of N-acetylmuramic acid 6-phosphate.
Pssm-ID: 240140 [Multi-domain] Cd Length: 257 Bit Score: 394.97 E-value: 5.51e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 14 QTMDLDALSTLELVNRFNQQDTLVAQAVKETLPEVAKAVDAAAEALKAGGRIIYMGAGTSGRLGVLDASECPPTFGVPHG 93
Cdd:cd05007 1 RSADLDRLSTLEILRLLNEEDKKVAAAVEAALPQIARAVDAAAERLRAGGRLIYVGAGTSGRLGVLDASELPPTFGTPPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 94 LVVGLIAGGPGALLKAVEGAEDNAQLGEDDLKDLNLTAKDLVVGLAASGRTPYVIGGLEYANRTGCTTVAISCNPGSPIA 173
Cdd:cd05007 81 RVVGLIAGGEPALTRAVEGAEDDEEAGAADLQAINLTERDVVIGIAASGRTPYVLGALRYARARGALTIGIACNPGSPLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 174 QVAAIAISPVVGPEALTGSTRLKSGTAQKLVLNMISTGAMVKFGKVYQNLMVDMQATNVKLVDRACRMVMEATGAGREEA 253
Cdd:cd05007 161 QLADIAIALITGPEVVAGSTRLKAGTAQKLALNMLSTAVMIRLGKVYGNLMVDVRATNEKLRERAIRIVMEATGVSRDEA 240
|
250
....*....|....*..
gi 658548680 254 EAVLKQTDHDVKPAILM 270
Cdd:cd05007 241 EAALEQAGGDVKTAILM 257
|
|
| TIGR00274 |
TIGR00274 |
N-acetylmuramic acid 6-phosphate etherase; This protein, MurQ, is involved in recycling ... |
6-296 |
3.63e-133 |
|
N-acetylmuramic acid 6-phosphate etherase; This protein, MurQ, is involved in recycling components of the bacterial murein sacculus turned over during cell growth. The cell wall metabolite anhydro-N-acetylmuramic acid (anhMurNAc) is converted by a kinase, AnmK, to MurNAc-phosphate, then converted to N-acetylglucosamine-phosphate by this etherase, called MurQ. This family of proteins is similar to the C-terminal half of a number of vertebrate glucokinase regulator proteins and contains a Prosite pattern which is shared by this group of proteins in a region of local similarity. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 272991 [Multi-domain] Cd Length: 291 Bit Score: 379.19 E-value: 3.63e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 6 LVSETRNPQTMDLDALSTLELVNRFNQQDTLVAQAVKETLPEVAKAVDAAAEALKAGGRIIYMGAGTSGRLGVLDASECP 85
Cdd:TIGR00274 1 LITEQRNPQSVEIDRQSTLEIVRLINEEDKLVPLAIESVLPDIAAAVEQIVQAFQQGGRLIYIGAGTSGRLGVLDASECP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 86 PTFGVPHGLVVGLIAGGPGALLKAVEGAEDNAQLGEDDLKDLNLTAKDLVVGLAASGRTPYVIGGLEYANRTGCTTVAIS 165
Cdd:TIGR00274 81 PTFGVSPELVKGIIAGGECAILHAVEGAEDSTEAGANDLQNIHLTKNDVVVGIAASGRTPYVIAGLQYARSLGALTISIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 166 CNPGSPIAQVAAIAISPVVGPEALTGSTRLKSGTAQKLVLNMISTGAMVKFGKVYQNLMVDMQATNVKLVDRACRMVMEA 245
Cdd:TIGR00274 161 CNPKSAMSEIADIAIETIVGPEILTGSSRLKAGTAQKMVLNMLSTASMIKLGKVYENLMVDVQASNEKLKARAVRIVMQA 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 658548680 246 TGAGREEAEAVLKQTDHDVKPAILMILSGLDAAAARAKLAAHNGFLRAALE 296
Cdd:TIGR00274 241 TDCNKELAEQTLLAADQNVKLAIVMILSTLSASEAKVLLDRHGGFLRQALD 291
|
|
| SIS |
pfam01380 |
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ... |
63-207 |
8.74e-09 |
|
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.
Pssm-ID: 426230 [Multi-domain] Cd Length: 131 Bit Score: 53.07 E-value: 8.74e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 63 GRIIYMGAGTSGRLGVldasecpptFGVPHglvVGLIAGgpgallKAVEGaEDNAQLGEDDLkdLNLTAKDLVVGLAASG 142
Cdd:pfam01380 6 KRIFVIGRGTSYAIAL---------ELALK---FEEIGY------KVVEV-ELASELRHGVL--ALVDEDDLVIAISYSG 64
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 658548680 143 RTPYVIGGLEYANRTGCTTVAISCNPGSPIAQVAAIAISPVVGPEALTGSTrlKSGTAQKLVLNM 207
Cdd:pfam01380 65 ETKDLLAAAELAKARGAKIIAITDSPGSPLAREADHVLYINAGPETGVAST--KSITAQLAALDA 127
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| murQ |
PRK05441 |
N-acetylmuramic acid-6-phosphate etherase; Reviewed |
1-297 |
2.64e-180 |
|
N-acetylmuramic acid-6-phosphate etherase; Reviewed
Pssm-ID: 235467 [Multi-domain] Cd Length: 299 Bit Score: 498.54 E-value: 2.64e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 1 MNLGSLVSETRNPQTMDLDALSTLELVNRFNQQDTLVAQAVKETLPEVAKAVDAAAEALKAGGRIIYMGAGTSGRLGVLD 80
Cdd:PRK05441 1 MMLENLTTEQRNPASMDLDQLSTLEILRLINEEDKKVALAVEKALPQIAAAVDAAAAALRQGGRLIYIGAGTSGRLGVLD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 81 ASECPPTFGVPHGLVVGLIAGGPGALLKAVEGAEDNAQLGEDDLKDLNLTAKDLVVGLAASGRTPYVIGGLEYANRTGCT 160
Cdd:PRK05441 81 ASECPPTFGVPPELVVGLIAGGEKALTKAVEGAEDDAELGAADLKAINLTAKDVVVGIAASGRTPYVIGALEYARERGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 161 TVAISCNPGSPIAQVAAIAISPVVGPEALTGSTRLKSGTAQKLVLNMISTGAMVKFGKVYQNLMVDMQATNVKLVDRACR 240
Cdd:PRK05441 161 TIGISCNPGSPLSKEADIAIEVVVGPEVLTGSTRMKAGTAQKLVLNMISTGVMIRLGKVYGNLMVDVKATNEKLVDRAVR 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 658548680 241 MVMEATGAGREEAEAVLKQTDHDVKPAILMILSGLDAAAARAKLAAHNGFLRAALEN 297
Cdd:PRK05441 241 IVMEATGVSREEAEAALEAADGSVKLAIVMILTGLDAAEAKALLARHGGFLRKALAE 297
|
|
| MurQ |
COG2103 |
N-acetylmuramic acid 6-phosphate (MurNAc-6-P) etherase [Cell wall/membrane/envelope biogenesis] ... |
1-297 |
2.88e-174 |
|
N-acetylmuramic acid 6-phosphate (MurNAc-6-P) etherase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441706 [Multi-domain] Cd Length: 301 Bit Score: 483.44 E-value: 2.88e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 1 MNLGSLVSETRNPQTMDLDALSTLELVNRFNQQDTLVAQAVKETLPEVAKAVDAAAEALKAGGRIIYMGAGTSGRLGVLD 80
Cdd:COG2103 2 MDLGKLTTEQRNPRSLDLDTLSTLEILRLINEEDAKVAAAVRAALPAIAAAVDAIAEALRAGGRLIYVGAGTSGRLGVLD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 81 ASECPPTFGVPHGLVVGLIAGGPGALLKAVEGAEDNAQLGEDDLKDLNLTAKDLVVGLAASGRTPYVIGGLEYANRTGCT 160
Cdd:COG2103 82 ASECPPTFGTPPERVVGLIAGGEEALFRAVEGAEDDEEAGAADLKALGLGPGDVVVGIAASGRTPYVIGALEYARARGAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 161 TVAISCNPGSPIAQVAAIAISPVVGPEALTGSTRLKSGTAQKLVLNMISTGAMVKFGKVYQNLMVDMQATNVKLVDRACR 240
Cdd:COG2103 162 TVAIACNPGSPLSAAADIAIELVTGPEVITGSTRLKAGTAQKLVLNMLSTAAMIRLGKVYGNLMVDVRATNAKLRDRAIR 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 658548680 241 MVMEATGAGREEAEAVLKQTDHDVKPAILMILSGLDAAAARAKLAAHNGFLRAALEN 297
Cdd:COG2103 242 IVMEATGCDEEEAEEALEAAGGHVKTAILMILTGLDAEEAEALLARAGGFLRKALAA 298
|
|
| PRK12570 |
PRK12570 |
N-acetylmuramic acid-6-phosphate etherase; Reviewed |
6-297 |
6.43e-162 |
|
N-acetylmuramic acid-6-phosphate etherase; Reviewed
Pssm-ID: 237142 [Multi-domain] Cd Length: 296 Bit Score: 452.22 E-value: 6.43e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 6 LVSETRNPQTMDLDALSTLELVNRFNQQDTLVAQAVKETLPEVAKAVDAAAEALKAGGRIIYMGAGTSGRLGVLDASECP 85
Cdd:PRK12570 2 LVSEGRNPATMDIDLLSSLDIVTLINQEDKKVPLAVEKVLPQIAQAVDKIVAAFKKGGRLIYMGAGTSGRLGVLDASECP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 86 PTFGVPHGLVVGLIAGGPGALLKAVEGAEDNAQLGEDDLKDLNLTAKDLVVGLAASGRTPYVIGGLEYANRTGCTTVAIS 165
Cdd:PRK12570 82 PTFSVSPEMVIGLIAGGPEAMFTAVEGAEDDPELGAQDLKAIGLTADDVVVGIAASGRTPYVIGALEYAKQIGATTIALS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 166 CNPGSPIAQVAAIAISPVVGPEALTGSTRLKSGTAQKLVLNMISTGAMVKFGKVYQNLMVDMQATNVKLVDRACRMVMEA 245
Cdd:PRK12570 162 CNPDSPIAKIADIAISPVVGPEVLTGSTRLKSGTAQKMVLNMLSTASMIRLGKSYQNLMVDVKATNEKLVARAVRIVMQA 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 658548680 246 TGAGREEAEAVLKQTDHDVKPAILMILSGLDAAAARAKLAAHNGFLRAALEN 297
Cdd:PRK12570 242 TGCSEDEAKELLKESDNDVKLAILMILTGMDVEQARAALSHADGFLRKAIEA 293
|
|
| SIS_Etherase |
cd05007 |
N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ... |
14-270 |
5.51e-140 |
|
N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid carries a unique D-lactyl ether substituent at the C3 position. The etherase catalyzes the cleavage of the lactyl ether bond of N-acetylmuramic acid 6-phosphate.
Pssm-ID: 240140 [Multi-domain] Cd Length: 257 Bit Score: 394.97 E-value: 5.51e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 14 QTMDLDALSTLELVNRFNQQDTLVAQAVKETLPEVAKAVDAAAEALKAGGRIIYMGAGTSGRLGVLDASECPPTFGVPHG 93
Cdd:cd05007 1 RSADLDRLSTLEILRLLNEEDKKVAAAVEAALPQIARAVDAAAERLRAGGRLIYVGAGTSGRLGVLDASELPPTFGTPPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 94 LVVGLIAGGPGALLKAVEGAEDNAQLGEDDLKDLNLTAKDLVVGLAASGRTPYVIGGLEYANRTGCTTVAISCNPGSPIA 173
Cdd:cd05007 81 RVVGLIAGGEPALTRAVEGAEDDEEAGAADLQAINLTERDVVIGIAASGRTPYVLGALRYARARGALTIGIACNPGSPLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 174 QVAAIAISPVVGPEALTGSTRLKSGTAQKLVLNMISTGAMVKFGKVYQNLMVDMQATNVKLVDRACRMVMEATGAGREEA 253
Cdd:cd05007 161 QLADIAIALITGPEVVAGSTRLKAGTAQKLALNMLSTAVMIRLGKVYGNLMVDVRATNEKLRERAIRIVMEATGVSRDEA 240
|
250
....*....|....*..
gi 658548680 254 EAVLKQTDHDVKPAILM 270
Cdd:cd05007 241 EAALEQAGGDVKTAILM 257
|
|
| TIGR00274 |
TIGR00274 |
N-acetylmuramic acid 6-phosphate etherase; This protein, MurQ, is involved in recycling ... |
6-296 |
3.63e-133 |
|
N-acetylmuramic acid 6-phosphate etherase; This protein, MurQ, is involved in recycling components of the bacterial murein sacculus turned over during cell growth. The cell wall metabolite anhydro-N-acetylmuramic acid (anhMurNAc) is converted by a kinase, AnmK, to MurNAc-phosphate, then converted to N-acetylglucosamine-phosphate by this etherase, called MurQ. This family of proteins is similar to the C-terminal half of a number of vertebrate glucokinase regulator proteins and contains a Prosite pattern which is shared by this group of proteins in a region of local similarity. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 272991 [Multi-domain] Cd Length: 291 Bit Score: 379.19 E-value: 3.63e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 6 LVSETRNPQTMDLDALSTLELVNRFNQQDTLVAQAVKETLPEVAKAVDAAAEALKAGGRIIYMGAGTSGRLGVLDASECP 85
Cdd:TIGR00274 1 LITEQRNPQSVEIDRQSTLEIVRLINEEDKLVPLAIESVLPDIAAAVEQIVQAFQQGGRLIYIGAGTSGRLGVLDASECP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 86 PTFGVPHGLVVGLIAGGPGALLKAVEGAEDNAQLGEDDLKDLNLTAKDLVVGLAASGRTPYVIGGLEYANRTGCTTVAIS 165
Cdd:TIGR00274 81 PTFGVSPELVKGIIAGGECAILHAVEGAEDSTEAGANDLQNIHLTKNDVVVGIAASGRTPYVIAGLQYARSLGALTISIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 166 CNPGSPIAQVAAIAISPVVGPEALTGSTRLKSGTAQKLVLNMISTGAMVKFGKVYQNLMVDMQATNVKLVDRACRMVMEA 245
Cdd:TIGR00274 161 CNPKSAMSEIADIAIETIVGPEILTGSSRLKAGTAQKMVLNMLSTASMIKLGKVYENLMVDVQASNEKLKARAVRIVMQA 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 658548680 246 TGAGREEAEAVLKQTDHDVKPAILMILSGLDAAAARAKLAAHNGFLRAALE 296
Cdd:TIGR00274 241 TDCNKELAEQTLLAADQNVKLAIVMILSTLSASEAKVLLDRHGGFLRQALD 291
|
|
| SIS_GlmS_GlmD_1 |
cd05008 |
SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and ... |
126-209 |
1.98e-11 |
|
SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal glutaminase domain and two C-terminal SIS domains and catalyzes the first step in hexosamine metabolism, converting fructose 6-phosphate into glucosamine 6-phosphate using glutamine as nitrogen source. The glutaminase domain hydrolyzes glutamine to glutamate and ammonia. Ammonia is transferred through a channel to the isomerase domain for glucosamine 6-phosphate synthesis. The end product of the pathway is N-acetylglucosamine, which plays multiple roles in eukaryotic cells including being a building block of bacterial and fungal cell walls. In the absence of glutamine, GlmS catalyzes the isomerization of fructose 6-phosphate into glucose 6- phosphate (PGI-like activity). Glucosamine-6-phosphate deaminase (GlmD) contains two SIS domains and catalyzes the deamination and isomerization of glucosamine-6-phosphate into fructose-6-phosphate with the release of ammonia; in presence of high ammonia concentration, GlmD can catalyze the reverse reaction.
Pssm-ID: 240141 [Multi-domain] Cd Length: 126 Bit Score: 60.20 E-value: 1.98e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 126 DLNLTAKDLVVGLAASGRTPYVIGGLEYANRTGCTTVAISCNPGSPIAQVAAIAISPVVGPEALTGSTrlKSGTAQKLVL 205
Cdd:cd05008 41 RPLLDEDTLVIAISQSGETADTLAALRLAKEKGAKTVAITNVVGSTLAREADYVLYLRAGPEISVAAT--KAFTSQLLAL 118
|
....
gi 658548680 206 NMIS 209
Cdd:cd05008 119 LLLA 122
|
|
| RpiR |
COG1737 |
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ... |
128-211 |
4.10e-09 |
|
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];
Pssm-ID: 441343 [Multi-domain] Cd Length: 286 Bit Score: 56.47 E-value: 4.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 128 NLTAKDLVVGLAASGRTPYVIGGLEYANRTGCTTVAISCNPGSPIAQVAAIAIsPVVGPEALTGSTRLKSGTAQKLVLNM 207
Cdd:COG1737 179 LLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVL-YVPSEEPTLRSSAFSSRVAQLALIDA 257
|
....
gi 658548680 208 ISTG 211
Cdd:COG1737 258 LAAA 261
|
|
| SIS |
pfam01380 |
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ... |
63-207 |
8.74e-09 |
|
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.
Pssm-ID: 426230 [Multi-domain] Cd Length: 131 Bit Score: 53.07 E-value: 8.74e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 63 GRIIYMGAGTSGRLGVldasecpptFGVPHglvVGLIAGgpgallKAVEGaEDNAQLGEDDLkdLNLTAKDLVVGLAASG 142
Cdd:pfam01380 6 KRIFVIGRGTSYAIAL---------ELALK---FEEIGY------KVVEV-ELASELRHGVL--ALVDEDDLVIAISYSG 64
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 658548680 143 RTPYVIGGLEYANRTGCTTVAISCNPGSPIAQVAAIAISPVVGPEALTGSTrlKSGTAQKLVLNM 207
Cdd:pfam01380 65 ETKDLLAAAELAKARGAKIIAITDSPGSPLAREADHVLYINAGPETGVAST--KSITAQLAALDA 127
|
|
| AgaS |
COG2222 |
Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain ... |
60-214 |
1.82e-08 |
|
Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441824 [Multi-domain] Cd Length: 336 Bit Score: 54.52 E-value: 1.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 60 KAGGRIIYMGAGTSGRLGVLdasecpptfgvphglVVGLIAGGPGALLKAVEGAEdnAQLGEDDLKDlnltAKDLVVGLA 139
Cdd:COG2222 32 KPPRRVVLVGAGSSDHAAQA---------------AAYLLERLLGIPVAALAPSE--LVVYPAYLKL----EGTLVVAIS 90
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 658548680 140 ASGRTPYVIGGLEYANRTGCTTVAISCNPGSPIAQVAAIAIspvvgpeaLTGSTRLKSGTAQKLVLNMISTGAMV 214
Cdd:COG2222 91 RSGNSPEVVAALELAKARGARTLAITNNPDSPLAEAADRVL--------PLPAGPEKSVAATKSFTTMLLALLAL 157
|
|
| SIS_Kpsf |
cd05014 |
KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ... |
129-188 |
3.27e-07 |
|
KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-phosphate to arabinose 5-phosphate. This is the second step in the CMP-Kdo biosynthesis pathway.
Pssm-ID: 240145 [Multi-domain] Cd Length: 128 Bit Score: 48.31 E-value: 3.27e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 129 LTAKDLVVGLAASGRTPYVIGGLEYANRTGCTTVAISCNPGSPIAQVAAIAISPVVGPEA 188
Cdd:cd05014 45 VTPGDVVIAISNSGETDELLNLLPHLKRRGAPIIAITGNPNSTLAKLSDVVLDLPVEEEA 104
|
|
| SIS_RpiR |
cd05013 |
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ... |
59-211 |
4.42e-07 |
|
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.
Pssm-ID: 240144 [Multi-domain] Cd Length: 139 Bit Score: 48.38 E-value: 4.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 59 LKAGGRIIYMGAGTSGRLGvLDASecppTFGVPHGLVVGLIAGGPGALLKAvegaednaqlgeddlkdLNLTAKDLVVGL 138
Cdd:cd05013 10 LAKARRIYIFGVGSSGLVA-EYLA----YKLLRLGKPVVLLSDPHLQLMSA-----------------ANLTPGDVVIAI 67
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 658548680 139 AASGRTPYVIGGLEYANRTGCTTVAISCNPGSPIAQVAAIAIsPVVGPEALTGSTRLKSGTAQKLVLNMISTG 211
Cdd:cd05013 68 SFSGETKETVEAAEIAKERGAKVIAITDSANSPLAKLADIVL-LVSSEEGDFRSSAFSSRIAQLALIDALFLA 139
|
|
| SIS |
cd04795 |
SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ... |
65-165 |
1.69e-06 |
|
SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.
Pssm-ID: 240112 [Multi-domain] Cd Length: 87 Bit Score: 45.44 E-value: 1.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 65 IIYMGAGTSGRLGVLDASECPPTFGVPhglVVGLIAGGpgallkavegaednaqlGEDDLKDLNLTAKDLVVGLAASGRT 144
Cdd:cd04795 1 IFVIGIGGSGAIAAYFALELLELTGIE---VVALIATE-----------------LEHASLLSLLRKGDVVIALSYSGRT 60
|
90 100
....*....|....*....|.
gi 658548680 145 PYVIGGLEYANRTGCTTVAIS 165
Cdd:cd04795 61 EELLAALEIAKELGIPVIAIT 81
|
|
| PRK11337 |
PRK11337 |
MurR/RpiR family transcriptional regulator; |
129-188 |
6.28e-05 |
|
MurR/RpiR family transcriptional regulator;
Pssm-ID: 183089 [Multi-domain] Cd Length: 292 Bit Score: 43.60 E-value: 6.28e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 658548680 129 LTAKDLVVGLAASGRTPYVIGGLEYANRTGCTTVAISCNPGSPIAQVAAIAI------SPVVGPEA 188
Cdd:PRK11337 185 LQEGDVVLVVSHSGRTSDVIEAVELAKKNGAKIICITNSYHSPIAKLADYVIcstaqgSPLLGENA 250
|
|
| SIS_PHI |
cd05005 |
Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) ... |
128-180 |
1.43e-04 |
|
Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with formadelhyde to become hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by PHI.
Pssm-ID: 240138 [Multi-domain] Cd Length: 179 Bit Score: 41.79 E-value: 1.43e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 658548680 128 NLTAKDLVVGLAASGRTPYVIGGLEYANRTGCTTVAISCNPGSPIAQVAAIAI 180
Cdd:cd05005 72 AIGPGDLLIAISGSGETSSVVNAAEKAKKAGAKVVLITSNPDSPLAKLADVVV 124
|
|
| SIS_1 |
cd05710 |
A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar ... |
129-176 |
1.88e-04 |
|
A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.
Pssm-ID: 240214 [Multi-domain] Cd Length: 120 Bit Score: 40.25 E-value: 1.88e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 658548680 129 LTAKDLVVGLAASGRTPYVIGGLEYANRTGCTTVAISCNPGSPIAQVA 176
Cdd:cd05710 45 LTEKSVVILASHSGNTKETVAAAKFAKEKGATVIGLTDDEDSPLAKLA 92
|
|
| GutQ |
COG0794 |
D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall ... |
129-188 |
5.02e-04 |
|
D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440557 [Multi-domain] Cd Length: 317 Bit Score: 41.12 E-value: 5.02e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 129 LTAKDLVVGLAASGRTPYVIGGLEYANRTGCTTVAISCNPGSPIAQVAAIAISPVVGPEA 188
Cdd:COG0794 89 ITPGDVVIAISNSGETEELLALLPLLKRLGVPLIAITGNPDSTLARAADVVLDLPVEREA 148
|
|
| SIS_GmhA |
cd05006 |
Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose ... |
129-180 |
6.53e-04 |
|
Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of gram-negative bacteria inner core lipopolysaccharide precursor, L-glycero-D-mannoheptose (Gmh).
Pssm-ID: 240139 [Multi-domain] Cd Length: 177 Bit Score: 39.80 E-value: 6.53e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 658548680 129 LTAKDLVVGLAASGRTPYVIGGLEYANRTGCTTVAISCNPGSPIAQVAAIAI 180
Cdd:cd05006 99 GQPGDVLIGISTSGNSPNVLKALEAAKERGMKTIALTGRDGGKLLELADIEI 150
|
|
| PRK13937 |
PRK13937 |
phosphoheptose isomerase; Provisional |
133-180 |
9.42e-04 |
|
phosphoheptose isomerase; Provisional
Pssm-ID: 184408 [Multi-domain] Cd Length: 188 Bit Score: 39.45 E-value: 9.42e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 658548680 133 DLVVGLAASGRTPYVIGGLEYANRTGCTTVAISCNPGSPIAQVAAIAI 180
Cdd:PRK13937 108 DVLIGISTSGNSPNVLAALEKARELGMKTIGLTGRDGGKMKELCDHLL 155
|
|
| SIS_2 |
pfam13580 |
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ... |
59-165 |
1.29e-03 |
|
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.
Pssm-ID: 433326 [Multi-domain] Cd Length: 138 Bit Score: 38.35 E-value: 1.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 59 LKAGGRIIYMGAGTSGrlgvLDASECPPTFG--VP-HGLVVGLIAGGPGALLKAVEGAEDNAQLGEDDLKDLNLTAKDLV 135
Cdd:pfam13580 32 LANGGKVYAFGTGHSA----APAEELFARAGglAGfEPILLPALALHTDASATISTALERDEGYARQILALYPGRPGDVL 107
|
90 100 110
....*....|....*....|....*....|
gi 658548680 136 VGLAASGRTPYVIGGLEYANRTGCTTVAIS 165
Cdd:pfam13580 108 IVISNSGINAVPVEAALEAKERGMKVIALT 137
|
|
| UBA_AeNAC |
cd14359 |
UBA-like domain found in archaeal nascent polypeptide-associated complex homolog from ... |
240-271 |
1.94e-03 |
|
UBA-like domain found in archaeal nascent polypeptide-associated complex homolog from Methanothermobacter marburgensis (AeNAC) and similar proteins; AeNAC is a functional archaeal homolog of eukaryotic nascent polypeptide-associated complex (NAC). Both AeNAC and eukaryotic NAC function as the cytosolic chaperone that can bind to ribosomal RNA, interact with the nascent polypeptide chains as they emerge from the ribosome, and assist in post-translational processes. They all contain a NAC domain and an ubiquitin-associated (UBA) domain in the C-terminus. However, unlike eukaryotic NAC, AeNAC forms a ribosome associated homodimer, but not heterodimer. The NAC domain of AeNAC is responsible for the homodimer formation.
Pssm-ID: 270542 [Multi-domain] Cd Length: 40 Bit Score: 35.28 E-value: 1.94e-03
10 20 30
....*....|....*....|....*....|..
gi 658548680 240 RMVMEATGAGREEAEAVLKQTDHDVKPAILMI 271
Cdd:cd14359 8 ELVMEQTGVSREEARKALEESGGDLAEAILKL 39
|
|
| EGD2 |
COG1308 |
Transcription factor homologous to NACalpha-BTF3 [Transcription]; |
240-274 |
4.63e-03 |
|
Transcription factor homologous to NACalpha-BTF3 [Transcription];
Pssm-ID: 440919 [Multi-domain] Cd Length: 116 Bit Score: 36.36 E-value: 4.63e-03
10 20 30
....*....|....*....|....*....|....*
gi 658548680 240 RMVMEATGAGREEAEAVLKQTDHDVKPAILMILSG 274
Cdd:COG1308 82 ELVAEQTGVSEEEAREALEEANGDLAEAILKLEEE 116
|
|
| GlmS |
COG0449 |
Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase ... |
126-209 |
5.43e-03 |
|
Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440218 [Multi-domain] Cd Length: 610 Bit Score: 38.07 E-value: 5.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548680 126 DLNLTAKDLVVGLAASGRTPYVIGGLEYANRTGCTTVAIsCN-PGSPIAQVAAIAISPVVGPE---AltgSTrlKSGTAQ 201
Cdd:COG0449 336 DPVVDPGTLVIAISQSGETADTLAALREAKEKGAKVLAI-CNvVGSTIARESDAVLYTHAGPEigvA---ST--KAFTTQ 409
|
....*...
gi 658548680 202 KLVLNMIS 209
Cdd:COG0449 410 LAALYLLA 417
|
|
| |
