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Conserved domains on  [gi|658548818|ref|WP_029741269|]
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acyl-homoserine-lactone synthase [Enterobacter asburiae]

Protein Classification

acyl-homoserine-lactone synthase( domain architecture ID 10008134)

acyl-homoserine-lactone (AHL) synthase is involved in regulating the expression of virulence genes in a process known as quorum-sensing; similar to Pseudomonas aeruginosa acyl-homoserinelactone synthase LasI and RhlI

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LasI COG3916
N-acyl-homoserine lactone synthase LasI (autoinducer biosynthesis) [Signal transduction ...
 5-183 6.95e-49

N-acyl-homoserine lactone synthase LasI (autoinducer biosynthesis) [Signal transduction mechanisms];


:

Pssm-ID: 443121 [Multi-domain]  Cd Length: 201  Bit Score: 158.17  E-value: 6.95e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548818   5 IEFFLHDYDDLPSALARELFRLRRKTFRDRLDWKVECVEDMEKDQFDNPNTTYLLGM-YEGELLCGARFINATHPTMISE 83
Cdd:COG3916    1 FEIISADNLHLHPELLDEMFRLRHRVFVEELGWEVPVPDGLEIDQYDDPSAHYLLAHdEDGRVVGCVRLLPTTGPYMLED 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548818  84 IFHNYFTETIIfPADVPCCEISRLFLDKERRDSSSLQGV--PASKALFLAMNIYCIKNKYHGMYAVVSRGMYAIFRHANW 161
Cdd:COG3916   81 VFPDLLDGGPA-PRRPDIWEISRFAVDKDFRRRLGERARrpRVALALFLAMVEYALENGITHLVAVMEPRLERLLRRLGW 159

                        170       180
                 ....*....|....*....|..
gi 658548818 162 KVEVIQRGVSEKGEVIYYIFMP 183
Cdd:COG3916  160 PFEPLGPPVEIGGERAPAYLID 181
 
Name Accession Description Interval E-value
LasI COG3916
N-acyl-homoserine lactone synthase LasI (autoinducer biosynthesis) [Signal transduction ...
 5-183 6.95e-49

N-acyl-homoserine lactone synthase LasI (autoinducer biosynthesis) [Signal transduction mechanisms];


Pssm-ID: 443121 [Multi-domain]  Cd Length: 201  Bit Score: 158.17  E-value: 6.95e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548818   5 IEFFLHDYDDLPSALARELFRLRRKTFRDRLDWKVECVEDMEKDQFDNPNTTYLLGM-YEGELLCGARFINATHPTMISE 83
Cdd:COG3916    1 FEIISADNLHLHPELLDEMFRLRHRVFVEELGWEVPVPDGLEIDQYDDPSAHYLLAHdEDGRVVGCVRLLPTTGPYMLED 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548818  84 IFHNYFTETIIfPADVPCCEISRLFLDKERRDSSSLQGV--PASKALFLAMNIYCIKNKYHGMYAVVSRGMYAIFRHANW 161
Cdd:COG3916   81 VFPDLLDGGPA-PRRPDIWEISRFAVDKDFRRRLGERARrpRVALALFLAMVEYALENGITHLVAVMEPRLERLLRRLGW 159

                        170       180
                 ....*....|....*....|..
gi 658548818 162 KVEVIQRGVSEKGEVIYYIFMP 183
Cdd:COG3916  160 PFEPLGPPVEIGGERAPAYLID 181
Autoind_synth pfam00765
Autoinducer synthase;
21-184 4.41e-40

Autoinducer synthase;


Pssm-ID: 366292  Cd Length: 182  Bit Score: 135.34  E-value: 4.41e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548818   21 RELFRLRRKTFRDRLDWKVECVEDMEKDQFDNPNTTYLLGMY-EGELLCGARFINATHPTMISEIFHNYFTETIIfPADV 99
Cdd:pfam00765  10 KEMFRLRKRVFKDRLGWDVQIIQGMERDQYDNLDPTYLLGVKdEGRVIGCVRLLETKGPNMLTGTFSSYLDGENI-PRSG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548818  100 PCCEISRLFLDKER---RDSSSLQgvPASKALFLAMNIYCIKNKYHGMYAVVSRGMYAIFRHANWKVEVIQRGVSEKGEV 176
Cdd:pfam00765  89 NYWESSRFCVDTDLvsgRAGNSIA--PATSTLFLGMIEYAMSAGYTGIVTIVDHPMLRILKRSGWPISYVGQPLSEGKEK 166


                  ....*...
gi 658548818  177 IYYIFMPA 184
Cdd:pfam00765 167 AYAALLPC 174
PRK13834 PRK13834
putative autoinducer synthesis protein; Provisional
 18-141 2.29e-14

putative autoinducer synthesis protein; Provisional


Pssm-ID: 172361  Cd Length: 207  Bit Score: 68.94  E-value: 2.29e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548818  18 ALARELFRLRRKTFRDRLDWKVECVEDMEKDQFDNPNTTYLLGMYEGELLCG-ARFINATHPTMISEIFHNYFtETIIFP 96
Cdd:PRK13834  16 SLLKQMHRLRARVFGGRLGWDVSITDGEERDQFDDLKPTYILAISDSGRVAGcARLLPAIGPTMLAQVFPQLL-PAGRLN 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 658548818  97 ADVPCCEISRLFLD---KERRDSSSLQgvPASKALFLAMNIYCIKNKY 141
Cdd:PRK13834  95 AHPAMIESSRFCVDtalAEGRGGGQLH--EATLTMFAGIIEWSMANGY 140
 
Name Accession Description Interval E-value
LasI COG3916
N-acyl-homoserine lactone synthase LasI (autoinducer biosynthesis) [Signal transduction ...
 5-183 6.95e-49

N-acyl-homoserine lactone synthase LasI (autoinducer biosynthesis) [Signal transduction mechanisms];


Pssm-ID: 443121 [Multi-domain]  Cd Length: 201  Bit Score: 158.17  E-value: 6.95e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548818   5 IEFFLHDYDDLPSALARELFRLRRKTFRDRLDWKVECVEDMEKDQFDNPNTTYLLGM-YEGELLCGARFINATHPTMISE 83
Cdd:COG3916    1 FEIISADNLHLHPELLDEMFRLRHRVFVEELGWEVPVPDGLEIDQYDDPSAHYLLAHdEDGRVVGCVRLLPTTGPYMLED 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548818  84 IFHNYFTETIIfPADVPCCEISRLFLDKERRDSSSLQGV--PASKALFLAMNIYCIKNKYHGMYAVVSRGMYAIFRHANW 161
Cdd:COG3916   81 VFPDLLDGGPA-PRRPDIWEISRFAVDKDFRRRLGERARrpRVALALFLAMVEYALENGITHLVAVMEPRLERLLRRLGW 159

                        170       180
                 ....*....|....*....|..
gi 658548818 162 KVEVIQRGVSEKGEVIYYIFMP 183
Cdd:COG3916  160 PFEPLGPPVEIGGERAPAYLID 181
Autoind_synth pfam00765
Autoinducer synthase;
21-184 4.41e-40

Autoinducer synthase;


Pssm-ID: 366292  Cd Length: 182  Bit Score: 135.34  E-value: 4.41e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548818   21 RELFRLRRKTFRDRLDWKVECVEDMEKDQFDNPNTTYLLGMY-EGELLCGARFINATHPTMISEIFHNYFTETIIfPADV 99
Cdd:pfam00765  10 KEMFRLRKRVFKDRLGWDVQIIQGMERDQYDNLDPTYLLGVKdEGRVIGCVRLLETKGPNMLTGTFSSYLDGENI-PRSG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548818  100 PCCEISRLFLDKER---RDSSSLQgvPASKALFLAMNIYCIKNKYHGMYAVVSRGMYAIFRHANWKVEVIQRGVSEKGEV 176
Cdd:pfam00765  89 NYWESSRFCVDTDLvsgRAGNSIA--PATSTLFLGMIEYAMSAGYTGIVTIVDHPMLRILKRSGWPISYVGQPLSEGKEK 166


                  ....*...
gi 658548818  177 IYYIFMPA 184
Cdd:pfam00765 167 AYAALLPC 174
PRK13834 PRK13834
putative autoinducer synthesis protein; Provisional
 18-141 2.29e-14

putative autoinducer synthesis protein; Provisional


Pssm-ID: 172361  Cd Length: 207  Bit Score: 68.94  E-value: 2.29e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548818  18 ALARELFRLRRKTFRDRLDWKVECVEDMEKDQFDNPNTTYLLGMYEGELLCG-ARFINATHPTMISEIFHNYFtETIIFP 96
Cdd:PRK13834  16 SLLKQMHRLRARVFGGRLGWDVSITDGEERDQFDDLKPTYILAISDSGRVAGcARLLPAIGPTMLAQVFPQLL-PAGRLN 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 658548818  97 ADVPCCEISRLFLD---KERRDSSSLQgvPASKALFLAMNIYCIKNKY 141
Cdd:PRK13834  95 AHPAMIESSRFCVDtalAEGRGGGQLH--EATLTMFAGIIEWSMANGY 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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