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Conserved domains on  [gi|658750611|ref|WP_029771749|]
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MULTISPECIES: histidine utilization repressor [unclassified Pseudoalteromonas]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
his_ut_repres super family cl33201
histidine utilization repressor, proteobacterial; This model represents a proteobacterial ...
 4-233 2.11e-108

histidine utilization repressor, proteobacterial; This model represents a proteobacterial histidine utilization repressor. It is usually found clustered with the enzymes HutUHIG so that it can regulate its own expression as well. A number of species have several paralogs and may fine-tune the regulation according to levels of degradation intermediates such as urocanate. This family belongs to the larger GntR family of transcriptional regulators. [Energy metabolism, Amino acids and amines, Regulatory functions, DNA interactions]


The actual alignment was detected with superfamily member TIGR02018:

Pssm-ID: 188194 [Multi-domain]  Cd Length: 230  Bit Score: 311.56  E-value: 2.11e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611    4 PKFAQIKQFIVDKIKNGAWQENQRVPSENELSSQFSVSRMTARRALSELTDAGILTRSQGLGTFVASFKSQSSLLEIKNI 83
Cdd:TIGR02018   1 PLYQRIKQDILERIRSGEWPPGHRIPSEHELVAQYGCSRMTVNRALRELTDAGLLERRQGVGTFVAEPKAQSALLEIRNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611   84 ADEVKERNGQYSCSVQVLESINAVAPIAIALGVEVDNVVYRSVLVHNENDKPLQVEERFVNPALAAGYLQQDFSALTPHE 163
Cdd:TIGR02018  81 ADEIVARGHRYRYELLELETRRATAEDAAALALPAGGKVFHSEIVHFENDVPFQLEDRLVNAAAVPDYLKQDFTQTTPGA 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611  164 YLSSVAPLTQARHTVEAVMPNSQMCQWLNLYNEEPCLQVIRRTWSTKGIVSFARLVSPGSKYRLGGHLTF 233
Cdd:TIGR02018 161 YLSQAAPLTEAEHRIEAISADPEEARLLAIDAGEPCLLIRRRTWSGAQVVTRARLLYPGSRYRLVGRFTP 230
 
Name Accession Description Interval E-value
his_ut_repres TIGR02018
histidine utilization repressor, proteobacterial; This model represents a proteobacterial ...
 4-233 2.11e-108

histidine utilization repressor, proteobacterial; This model represents a proteobacterial histidine utilization repressor. It is usually found clustered with the enzymes HutUHIG so that it can regulate its own expression as well. A number of species have several paralogs and may fine-tune the regulation according to levels of degradation intermediates such as urocanate. This family belongs to the larger GntR family of transcriptional regulators. [Energy metabolism, Amino acids and amines, Regulatory functions, DNA interactions]


Pssm-ID: 188194 [Multi-domain]  Cd Length: 230  Bit Score: 311.56  E-value: 2.11e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611    4 PKFAQIKQFIVDKIKNGAWQENQRVPSENELSSQFSVSRMTARRALSELTDAGILTRSQGLGTFVASFKSQSSLLEIKNI 83
Cdd:TIGR02018   1 PLYQRIKQDILERIRSGEWPPGHRIPSEHELVAQYGCSRMTVNRALRELTDAGLLERRQGVGTFVAEPKAQSALLEIRNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611   84 ADEVKERNGQYSCSVQVLESINAVAPIAIALGVEVDNVVYRSVLVHNENDKPLQVEERFVNPALAAGYLQQDFSALTPHE 163
Cdd:TIGR02018  81 ADEIVARGHRYRYELLELETRRATAEDAAALALPAGGKVFHSEIVHFENDVPFQLEDRLVNAAAVPDYLKQDFTQTTPGA 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611  164 YLSSVAPLTQARHTVEAVMPNSQMCQWLNLYNEEPCLQVIRRTWSTKGIVSFARLVSPGSKYRLGGHLTF 233
Cdd:TIGR02018 161 YLSQAAPLTEAEHRIEAISADPEEARLLAIDAGEPCLLIRRRTWSGAQVVTRARLLYPGSRYRLVGRFTP 230
PRK14999 PRK14999
histidine utilization repressor; Provisional
 4-232 5.18e-90

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 265.26  E-value: 5.18e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611   4 PKFAQIKQFIVDKIKNGAWQENQRVPSENELSSQFSVSRMTARRALSELTDAGILTRSQGLGTFVASFKSQSSLLEIKNI 83
Cdd:PRK14999  12 PFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPKGQSALFEVRSI 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611  84 ADEVKERNGQYSCSVQVLESINAVAPIAIALGVEVDNVVYRSVLVHNENDKPLQVEERFVNPALAAGYLQQDFSALTPHE 163
Cdd:PRK14999  92 AEEIAARRHQHRCEVLTLERVRANAIQASALNVNESDVIFHSIMVHYENDLPVQIEDRCVNADIAVDYLTQDYRQTTPHA 171

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 658750611 164 YLSSVAPLTQARHTVEAVMPNSQMCQWLNLYNEEPCLQVIRRTWSTKGIVSFARLVSPGSKYRLGGHLT 232
Cdd:PRK14999 172 YLSRIAPLTEGEHIVEAVRATAQECAWLTIKEHEPCLLIRRTTWSASRIVSHARLLFPGSRYRLQGRFI 240
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
3-232 1.07e-69

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 213.57  E-value: 1.07e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611   3 TPKFAQIKQFIVDKIKNGAWQENQRVPSENELSSQFSVSRMTARRALSELTDAGILTRSQGLGTFVASFKSQSSLLEIKN 82
Cdd:COG2188    4 VPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611  83 IADEVKERNGQYSCSVQVLESINAVAPIAIALGVEVDNVVYRSVLVHNENDKPLQVEERFVNPALAAGYLQQDFSALTPH 162
Cdd:COG2188   84 FTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLETGSLY 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 658750611 163 EYLSSVA--PLTQARHTVEAVMPNSQMCQWLNLYNEEPCLQVIRRTWSTKG-IVSFARLVSPGSKYRLGGHLT 232
Cdd:COG2188  164 ELLEERYglRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGrPVEYSRSYYRGDRYRFVVELR 236
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 89-226 6.11e-30

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 108.45  E-value: 6.11e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611   89 ERNGQYSCSVQVLESINAVAPIAIALGVEVDNVVYRSVLVHNENDKPLQVEERFVNPALAAGYLQQDFSALTPHEYLSSV 168
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLEEGSLYDYLEER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 658750611  169 --APLTQARHTVEAVMPNSQMCQWLNLYNEEPCLQVIRRTWSTKG-IVSFARLVSPGSKYR 226
Cdd:pfam07702  81 ygLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGrPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 89-226 5.82e-26

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 98.13  E-value: 5.82e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611    89 ERNGQYSCSVQVLESINAVAPIAIALGVEVDNVVYRSVLVHNENDKPLQVEERFVNPALAAGYLQQDFSA---LTPHEYL 165
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGslyEYLEERL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 658750611   166 SSVAP-LTQARHTVEAVMPNSQMCQWLNLYNEEPCLQVIRRTWSTKG-IVSFARLVSPGSKYR 226
Cdd:smart00866  81 GLKIVrSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGrPVEYSRSYYRGDRFR 143
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 4-69 3.95e-23

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 88.66  E-value: 3.95e-23
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 658750611   4 PKFAQIKQFIVDKIKNGAWQENQRVPSENELSSQFSVSRMTARRALSELTDAGILTRSQGLGTFVA 69
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
his_ut_repres TIGR02018
histidine utilization repressor, proteobacterial; This model represents a proteobacterial ...
 4-233 2.11e-108

histidine utilization repressor, proteobacterial; This model represents a proteobacterial histidine utilization repressor. It is usually found clustered with the enzymes HutUHIG so that it can regulate its own expression as well. A number of species have several paralogs and may fine-tune the regulation according to levels of degradation intermediates such as urocanate. This family belongs to the larger GntR family of transcriptional regulators. [Energy metabolism, Amino acids and amines, Regulatory functions, DNA interactions]


Pssm-ID: 188194 [Multi-domain]  Cd Length: 230  Bit Score: 311.56  E-value: 2.11e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611    4 PKFAQIKQFIVDKIKNGAWQENQRVPSENELSSQFSVSRMTARRALSELTDAGILTRSQGLGTFVASFKSQSSLLEIKNI 83
Cdd:TIGR02018   1 PLYQRIKQDILERIRSGEWPPGHRIPSEHELVAQYGCSRMTVNRALRELTDAGLLERRQGVGTFVAEPKAQSALLEIRNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611   84 ADEVKERNGQYSCSVQVLESINAVAPIAIALGVEVDNVVYRSVLVHNENDKPLQVEERFVNPALAAGYLQQDFSALTPHE 163
Cdd:TIGR02018  81 ADEIVARGHRYRYELLELETRRATAEDAAALALPAGGKVFHSEIVHFENDVPFQLEDRLVNAAAVPDYLKQDFTQTTPGA 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611  164 YLSSVAPLTQARHTVEAVMPNSQMCQWLNLYNEEPCLQVIRRTWSTKGIVSFARLVSPGSKYRLGGHLTF 233
Cdd:TIGR02018 161 YLSQAAPLTEAEHRIEAISADPEEARLLAIDAGEPCLLIRRRTWSGAQVVTRARLLYPGSRYRLVGRFTP 230
PRK14999 PRK14999
histidine utilization repressor; Provisional
 4-232 5.18e-90

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 265.26  E-value: 5.18e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611   4 PKFAQIKQFIVDKIKNGAWQENQRVPSENELSSQFSVSRMTARRALSELTDAGILTRSQGLGTFVASFKSQSSLLEIKNI 83
Cdd:PRK14999  12 PFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPKGQSALFEVRSI 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611  84 ADEVKERNGQYSCSVQVLESINAVAPIAIALGVEVDNVVYRSVLVHNENDKPLQVEERFVNPALAAGYLQQDFSALTPHE 163
Cdd:PRK14999  92 AEEIAARRHQHRCEVLTLERVRANAIQASALNVNESDVIFHSIMVHYENDLPVQIEDRCVNADIAVDYLTQDYRQTTPHA 171

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 658750611 164 YLSSVAPLTQARHTVEAVMPNSQMCQWLNLYNEEPCLQVIRRTWSTKGIVSFARLVSPGSKYRLGGHLT 232
Cdd:PRK14999 172 YLSRIAPLTEGEHIVEAVRATAQECAWLTIKEHEPCLLIRRTTWSASRIVSHARLLFPGSRYRLQGRFI 240
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
3-232 1.07e-69

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 213.57  E-value: 1.07e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611   3 TPKFAQIKQFIVDKIKNGAWQENQRVPSENELSSQFSVSRMTARRALSELTDAGILTRSQGLGTFVASFKSQSSLLEIKN 82
Cdd:COG2188    4 VPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611  83 IADEVKERNGQYSCSVQVLESINAVAPIAIALGVEVDNVVYRSVLVHNENDKPLQVEERFVNPALAAGYLQQDFSALTPH 162
Cdd:COG2188   84 FTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLETGSLY 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 658750611 163 EYLSSVA--PLTQARHTVEAVMPNSQMCQWLNLYNEEPCLQVIRRTWSTKG-IVSFARLVSPGSKYRLGGHLT 232
Cdd:COG2188  164 ELLEERYglRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGrPVEYSRSYYRGDRYRFVVELR 236
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 89-226 6.11e-30

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 108.45  E-value: 6.11e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611   89 ERNGQYSCSVQVLESINAVAPIAIALGVEVDNVVYRSVLVHNENDKPLQVEERFVNPALAAGYLQQDFSALTPHEYLSSV 168
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLEEGSLYDYLEER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 658750611  169 --APLTQARHTVEAVMPNSQMCQWLNLYNEEPCLQVIRRTWSTKG-IVSFARLVSPGSKYR 226
Cdd:pfam07702  81 ygLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGrPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 89-226 5.82e-26

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 98.13  E-value: 5.82e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611    89 ERNGQYSCSVQVLESINAVAPIAIALGVEVDNVVYRSVLVHNENDKPLQVEERFVNPALAAGYLQQDFSA---LTPHEYL 165
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGslyEYLEERL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 658750611   166 SSVAP-LTQARHTVEAVMPNSQMCQWLNLYNEEPCLQVIRRTWSTKG-IVSFARLVSPGSKYR 226
Cdd:smart00866  81 GLKIVrSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGrPVEYSRSYYRGDRFR 143
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 4-69 3.95e-23

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 88.66  E-value: 3.95e-23
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 658750611   4 PKFAQIKQFIVDKIKNGAWQENQRVPSENELSSQFSVSRMTARRALSELTDAGILTRSQGLGTFVA 69
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
PRK11402 PRK11402
transcriptional regulator PhoB;
3-139 2.86e-22

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 91.43  E-value: 2.86e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611   3 TPKFAQIKQFIVDKIKNGAWQENQRVPSENELSSQFSVSRMTARRALSELTDAGILTRSQGLGTFVASFKSQSSLLEIkN 82
Cdd:PRK11402   8 QLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLTV-S 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611  83 IADEVKERNGQYScSVQVLE-SINAVAPIAIALGVEVDNVVY--RSVLVHneNDKPLQVE 139
Cdd:PRK11402  87 GFTDFGVSQGKAT-KEKVIEqERVSAAPFCEKLNIPGNSEVFhlCRVMYL--DKEPLFID 143
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
3-70 6.49e-18

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 76.37  E-value: 6.49e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 658750611   3 TPKFAQIKQFIVDKIKNGAWQENQRVPSENELSSQFSVSRMTARRALSELTDAGILTRSQGLGTFVAS 70
Cdd:COG1725    9 VPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAE 76
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 8-68 4.86e-17

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 72.65  E-value: 4.86e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 658750611    8 QIKQFIVDKIKNGAWQENQRVPSENELSSQFSVSRMTARRALSELTDAGILTRSQGLGTFV 68
Cdd:pfam00392   4 QVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
9-68 1.77e-16

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 71.07  E-value: 1.77e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611     9 IKQFIVDKIKNGAWQENQRVPSENELSSQFSVSRMTARRALSELTDAGILTRSQGLGTFV 68
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 8-202 2.39e-16

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 75.21  E-value: 2.39e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611    8 QIKQFIVDKIKNGAWQENQRVPSENELSSQFSVSRMTARRALSELTDAGILTRSQGLGTFVAS------FKSQSSLLEik 81
Cdd:TIGR02325  12 QIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAArridypLSARTRFSQ-- 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611   82 NIADEVKERNGqyscsvQVLESIN--AVAPIAIALGVEVDNVVYRSVLVHNENDKPLQVEERFVNPALAAGYLQQDFSAL 159
Cdd:TIGR02325  90 NLADQGREPTG------ELLLSDLepASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFPGIGQAYAASG 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 658750611  160 TPHEYLS--SVAPLTQARHTVEAVMPNSQMCQWLNLYNEEPCLQV 202
Cdd:TIGR02325 164 SITDALReqGVADYRRSSTRISARHADAKDCARLELPPGRPLLVV 208
PRK09764 PRK09764
GntR family transcriptional regulator;
4-213 1.66e-15

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 72.94  E-value: 1.66e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611   4 PKFAQIKQFIVDKIKNGAWQENQRVPSENELSSQFSVSRMTARRALSELTDAGILTRSQGLGTFVASFKSQSSLLEIKNI 83
Cdd:PRK09764   5 PLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQLTSF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611  84 ADEVKERNGQYSCSVQVLESINAVAPIAIALGVEVDNVVYRSVLVHNENDKPLQVEERFVNPALAAGyLQQDFSALTPHE 163
Cdd:PRK09764  85 DEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPD-LTWQVMENSKYH 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 658750611 164 YLSSVAPLTQARHTVE--AVMPNSQMCQWLNLYNEEPCLQVIRRTWSTKGIV 213
Cdd:PRK09764 164 FIEEVKKMVIDRSEQEiiPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRV 215
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
13-77 2.02e-15

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 72.66  E-value: 2.02e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 658750611  13 IVDKIKNGAWQENQRVPSENELSSQFSVSRMTARRALSELTDAGILTRSQGLGTFVASFKSQSSL 77
Cdd:COG2186   16 LRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALL 80
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 1-115 6.23e-14

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 70.24  E-value: 6.23e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611   1 MTTPKFAQIKQFIVDKIKNGAWQENQRVPSENELSSQFSVSRMTARRALSELTDAGILTRSQGLGTFVASfksqssllei 80
Cdd:COG1167    9 SSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAA---------- 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 658750611  81 kNIADEVKERNGQYSCSVQVLESINAVAPIAIALG 115
Cdd:COG1167   79 -RLPAPAPAPRAAAAVAAPALRRLLEAAPGVIDLG 112
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
7-75 2.04e-09

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 56.18  E-value: 2.04e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 658750611   7 AQIKQFIVDkiknGAWQENQRVPSENELSSQFSVSRMTARRALSELTDAGILTRSQGLGTFVASFKSQS 75
Cdd:PRK09464  17 QQLEFLILE----GTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSSLWQS 81
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 28-210 1.81e-08

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 53.24  E-value: 1.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611  28 VPSENELSSQFSVSRMTARRALSELTDAGILTRSQGLGTFV----------ASFKSQSSLLEikniadevkerNGQYSCS 97
Cdd:PRK10079  35 LPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVlmrpydyplnAQARFSQNLLD-----------QGSHPTS 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611  98 VQVLESIN-AVAPIAIALGV-EVDNVVYRSVLvHNENDKPLQVEERFVnPALAAGYLQQDFSALTPHEYLSSV--APLTQ 173
Cdd:PRK10079 104 EKLLSVLRpASGHVADALGItEGENVIHLRTL-RRVNGVALCLIDHYF-ADLTWWPTLQRFDSGSLHDFLREQlgIALRR 181

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 658750611 174 ARHTVEAVMPNSQMCQWLNLYNEEPCLQVirRTWSTK 210
Cdd:PRK10079 182 SQTRISARRAQAKESQLLEIPNMSPLLCV--RTLNHR 216
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 10-90 9.46e-07

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 48.21  E-value: 9.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658750611  10 KQFIVDKIkngawQENQRVPSEnELSSQFSVSRMTARRALSELTDAGILTRSQGLGTFVASFKSQSSLLEIKNIADEVKE 89
Cdd:COG1349    7 RQKILELL-----RERGRVSVE-ELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEPPFAERETLNAEEKR 80


                 .
gi 658750611  90 R 90
Cdd:COG1349   81 A 81
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 23-68 4.43e-06

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 46.30  E-value: 4.43e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 658750611  23 QENQRVPSENELSSQFSVSRMTARRALSELTDAGILTRSQGLGTFV 68
Cdd:PRK10421  21 EAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFI 66
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
24-63 1.10e-05

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 41.82  E-value: 1.10e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 658750611    24 ENQRVPSENELSSQFSVSRMTARRALSELTDAGILTRSQG 63
Cdd:smart00420  10 AQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHG 49
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
8-80 1.27e-05

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 44.91  E-value: 1.27e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 658750611   8 QIKQFIVDKIKNGAWQENQRVpSENELSSQFSVSRMTARRALSELTDAGILTRSQGLGTFVASFkSQSSLLEI 80
Cdd:COG1802   15 QVYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPL-SPEEIREL 85
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 9-74 4.76e-05

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 43.22  E-value: 4.76e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 658750611   9 IKQFIVDkiknGAWQENQRVPSENELSSQFSVSRMTARRALSELTDAGILTRSQGLGTFVASFKSQ 74
Cdd:PRK09990  16 IERLIVD----GVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVARLNRV 77
HTH_DeoR pfam08220
DeoR-like helix-turn-helix domain;
30-63 8.49e-05

DeoR-like helix-turn-helix domain;


Pssm-ID: 285436 [Multi-domain]  Cd Length: 57  Bit Score: 39.17  E-value: 8.49e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 658750611   30 SENELSSQFSVSRMTARRALSELTDAGILTRSQG 63
Cdd:pfam08220  16 SVEELAELLGVSEMTIRRDLNELEEQGLLTRTHG 49
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
30-62 2.72e-03

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 36.87  E-value: 2.72e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 658750611  30 SENELSSQFSVSRMTARRALSELTDAGILTRSQ 62
Cdd:COG3355   44 TVEELAEALDRSRSTVYRSLQKLLEAGLVEREK 76
PRK10225 PRK10225
Uxu operon transcriptional regulator;
6-77 3.15e-03

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 37.69  E-value: 3.15e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 658750611   6 FAQIKQFIVDKIKNGAWQENQRVPSENELSSQFSVSRMTARRALSELTDAGILTRSQGLGTFVASFKSQSSL 77
Cdd:PRK10225  11 YQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSHNT 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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