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Conserved domains on  [gi|658757157|ref|WP_029774040|]
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MULTISPECIES: response regulator transcription factor [Pseudoalteromonas]

Protein Classification

response regulator transcription factor( domain architecture ID 11433066)

OmpR family response regulator transcription factor with a signal receiver (REC) domain and a helix-turn-helix (HTH) DNA-binding domain that may be part of a two-component regulatory system

CATH:  3.40.50.2300
Gene Ontology:  GO:0006355|GO:0003677|GO:0000160|GO:0000156
PubMed:  11226872|10966457|31100988
SCOP:  4003632

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-201 1.12e-51

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


:

Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 165.90  E-value: 1.12e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   1 MRILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILTA 80
Cdd:COG0745    2 PRILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIMLTA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157  81 RAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRRNQGlgkDIISYGNLdFDRKSCTVTIAKELIDLKQREFRLLEI 160
Cdd:COG0745   82 RDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRRAA---EVLRVGDL-LDLAAREVTRDGEPVELTPKEFRLLEL 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 658757157 161 FLTHQGKVLNKDELLDHLYSFDDsPSPNAIETYVARLRKKL 201
Cdd:COG0745  158 LMRNPGRVVSREQLLEEVWGYDY-GDDRTVDVHISRLRKKL 197
 
Name Accession Description Interval E-value
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-201 1.12e-51

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 165.90  E-value: 1.12e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   1 MRILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILTA 80
Cdd:COG0745    2 PRILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIMLTA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157  81 RAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRRNQGlgkDIISYGNLdFDRKSCTVTIAKELIDLKQREFRLLEI 160
Cdd:COG0745   82 RDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRRAA---EVLRVGDL-LDLAAREVTRDGEPVELTPKEFRLLEL 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 658757157 161 FLTHQGKVLNKDELLDHLYSFDDsPSPNAIETYVARLRKKL 201
Cdd:COG0745  158 LMRNPGRVVSREQLLEEVWGYDY-GDDRTVDVHISRLRKKL 197
PRK15479 PRK15479
transcriptional regulator TctD;
1-218 1.20e-50

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 163.74  E-value: 1.20e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   1 MRILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILTA 80
Cdd:PRK15479   1 MRLLLAEDNRELAHWLEKALVQNGFAVDCVFDGLAADHLLQSEMYALAVLDINMPGMDGLEVLQRLRKRGQTLPVLLLTA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157  81 RAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRRNQGLGKDIISYGNLDFDRKScTVTIAKELIDLKQREFRLLEI 160
Cdd:PRK15479  81 RSAVADRVKGLNVGADDYLPKPFELEELDARLRALLRRSAGQVQEVQQLGELIFHDEG-YFLLQGQPLALTPREQALLTV 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 658757157 161 FLTHQGKVLNKDELLDHLYSFDDSPSPNAIETYVARLRKKLVNSSVDIKTLRGLGYLL 218
Cdd:PRK15479 160 LMYRRTRPVSRQQLFEQVFSLNDEVSPESIELYIHRLRKKLQGSDVRITTLRGLGYVL 217
PhoB TIGR02154
phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response ...
 2-218 3.46e-37

phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response regulator protein acting with PhoR in a 2-component system responding to phosphate ion. PhoB acts as a positive regulator of gene expression for phosphate-related genes such as phoA, phoS, phoE and ugpAB as well as itself. It is often found proximal to genes for the high-affinity phosphate ABC transporter (pstSCAB; GenProp0190) and presumably regulates these as well. [Regulatory functions, DNA interactions, Signal transduction, Two-component systems]


Pssm-ID: 131209 [Multi-domain]  Cd Length: 226  Bit Score: 129.37  E-value: 3.46e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157    2 RILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSS--NTPVLILT 79
Cdd:TIGR02154   4 RILVVEDEPAIRELIAYNLEKAGYDVVEAGDGDEALTLINERGPDLILLDWMLPGTSGIELCRRLRRRPEtrAIPIIMLT 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   80 ARAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRR-NQGLGKDIISYGNLDFDRKSCTVTIAKELIDLKQREFRLL 158
Cdd:TIGR02154  84 ARGEEEDRVRGLETGADDYITKPFSPRELLARIKAVLRRiRPQLSDEVIEVGDLSLDPVAHRVFRGGQPLSLGPTEFRLL 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 658757157  159 EIFLTHQGKVLNKDELLDHLYSFDDSPSPNAIETYVARLRKKLVNSSVD--IKTLRGLGYLL 218
Cdd:TIGR02154 164 HFFMTHPERVYSREQLLDRVWGRDVYVEERTVDVHIRRLRKALNPFGLEdpVQTVRGAGYRF 225
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 3-117 1.33e-30

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 109.11  E-value: 1.33e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   3 ILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILTARA 82
Cdd:cd17624    1 ILLVEDDALLGDGLKTGLRKAGYAVDWVRTGAEAEAALASGPYDLVILDLGLPDGDGLDLLRRWRRQGQSLPVLILTARD 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 658757157  83 QVEHRIELLDLGADDYLTKPFDFGELEARCRALLR 117
Cdd:cd17624   81 GVDDRVAGLDAGADDYLVKPFALEELLARLRALLR 115
MtrAB_MtrA NF040689
MtrAB system response regulator MtrA;
59-216 3.80e-23

MtrAB system response regulator MtrA;


Pssm-ID: 468653 [Multi-domain]  Cd Length: 219  Bit Score: 92.62  E-value: 3.80e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157  59 GEQILKKLRArSSNTPVLILTARAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRRNQGLGKDIISYGNLDFDRKS 138
Cdd:NF040689  57 GIEVCRQIRA-ESGVPIIMLTAKSDTVDVVRGLEAGADDYVVKPFKPKELVARIRARLRRSEDEESEVLRIGDLTIDVAG 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157 139 CTVTIAKELIDLKQREFRLLEIFLTHQGKVLNKDELLDHLYSFDDSPSPNAIETYVARLRKKLV----NSSVdIKTLRGL 214
Cdd:NF040689 136 HEVTRGGEEIPLTPLEFDLLVALARKPGQVFSREELLEQVWGYRHAADTRLVNVHVQRLRAKIErdpeNPEI-VVTVRGV 214


                 ..
gi 658757157 215 GY 216
Cdd:NF040689 215 GY 216
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 146-218 2.54e-21

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 83.76  E-value: 2.54e-21
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 658757157   146 ELIDLKQREFRLLEIFLTHQGKVLNKDELLDHLYSFDDSPSPNAIETYVARLRKKL--VNSSVDIKTLRGLGYLL 218
Cdd:smart00862   2 EPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDEDVDDNTLDVHISRLRKKLedDGDPRLIETVRGVGYRL 76
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
146-218 9.74e-21

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 82.18  E-value: 9.74e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 658757157  146 ELIDLKQREFRLLEIFLTHQGKVLNKDELLDHLYSFDDSPSPNAIETYVARLRKKL---VNSSVDIKTLRGLGYLL 218
Cdd:pfam00486   2 EEVELTPKEFKLLELLAENPGRVVSREQLLEEVWGEDYDVDDNTVDVHISRLRKKLeddPRDPRLIKTVRGVGYRL 77
resp_reg_YycF NF040534
response regulator YycF;
59-221 5.86e-20

response regulator YycF;


Pssm-ID: 439744 [Multi-domain]  Cd Length: 231  Bit Score: 84.39  E-value: 5.86e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157  59 GEQILKKLRaRSSNTPVLILTARAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRRNQGLGKD-------IISYGN 131
Cdd:NF040534  59 GMEVCREVR-KKYDMPIIMLTAKDSEIDKVLGLELGADDYVTKPFSTRELIARVKANLRRHQQQNTEeeeeennEIVIGS 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157 132 LDFDRKSCTVTIAKELIDLKQREFRLLEIFLTHQGKVLNKDELLDHLYSFDDSPSPNAIETYVARLRKKLVNSSVD---I 208
Cdd:NF040534 138 LTIHPDAYTVKKRGETIELTHREFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHpewI 217

                        170
                 ....*....|...
gi 658757157 209 KTLRGLGYLLAEP 221
Cdd:NF040534 218 VTRRGVGYYLRNP 230
 
Name Accession Description Interval E-value
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-201 1.12e-51

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 165.90  E-value: 1.12e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   1 MRILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILTA 80
Cdd:COG0745    2 PRILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIMLTA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157  81 RAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRRNQGlgkDIISYGNLdFDRKSCTVTIAKELIDLKQREFRLLEI 160
Cdd:COG0745   82 RDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRRAA---EVLRVGDL-LDLAAREVTRDGEPVELTPKEFRLLEL 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 658757157 161 FLTHQGKVLNKDELLDHLYSFDDsPSPNAIETYVARLRKKL 201
Cdd:COG0745  158 LMRNPGRVVSREQLLEEVWGYDY-GDDRTVDVHISRLRKKL 197
PRK15479 PRK15479
transcriptional regulator TctD;
1-218 1.20e-50

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 163.74  E-value: 1.20e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   1 MRILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILTA 80
Cdd:PRK15479   1 MRLLLAEDNRELAHWLEKALVQNGFAVDCVFDGLAADHLLQSEMYALAVLDINMPGMDGLEVLQRLRKRGQTLPVLLLTA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157  81 RAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRRNQGLGKDIISYGNLDFDRKScTVTIAKELIDLKQREFRLLEI 160
Cdd:PRK15479  81 RSAVADRVKGLNVGADDYLPKPFELEELDARLRALLRRSAGQVQEVQQLGELIFHDEG-YFLLQGQPLALTPREQALLTV 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 658757157 161 FLTHQGKVLNKDELLDHLYSFDDSPSPNAIETYVARLRKKLVNSSVDIKTLRGLGYLL 218
Cdd:PRK15479 160 LMYRRTRPVSRQQLFEQVFSLNDEVSPESIELYIHRLRKKLQGSDVRITTLRGLGYVL 217
PRK10643 PRK10643
two-component system response regulator PmrA;
1-223 3.36e-49

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 160.20  E-value: 3.36e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   1 MRILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILTA 80
Cdd:PRK10643   1 MKILIVEDDTLLLQGLILALQTEGYACDCASTAREAEALLESGHYSLVVLDLGLPDEDGLHLLRRWRQKKYTLPVLILTA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157  81 RAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRRNQGLGKDIISYGNLDFDRKSCTVTIAKELIDLKQREFRLLEI 160
Cdd:PRK10643  81 RDTLEDRVAGLDVGADDYLVKPFALEELHARIRALIRRHQGQGENELQVGNLTLNLGRQQVWLDGQELILTPKEFALLSR 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 658757157 161 FLTHQGKVLNKDELLDHLYSFDDSPSPNAIETYVARLRKKLVNSSvdIKTLRGLGYLLAEPNE 223
Cdd:PRK10643 161 LMLKAGSPVHREILYQDIYNWDDEPSSNTLEVHIHNLRDKVGKDR--IRTVRGFGYMLVANEE 221
PRK10336 PRK10336
two-component system response regulator QseB;
1-221 1.83e-47

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 155.82  E-value: 1.83e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   1 MRILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILTA 80
Cdd:PRK10336   1 MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157  81 RAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRRNQGLGKDIISYGNLDFDRKSCTVTIAKELIDLKQREFRLLEI 160
Cdd:PRK10336  81 RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 658757157 161 FLTHQGKVLNKDELLDHLYSFDDSPSPNAIETYVARLRKKLvnSSVDIKTLRGLGYLLAEP 221
Cdd:PRK10336 161 LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKL--GSDFIRTVHGIGYTLGEK 219
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 1-223 2.51e-40

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 137.75  E-value: 2.51e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   1 MRILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILTA 80
Cdd:PRK09836   1 MKLLIVEDEKKTGEYLTKGLTEAGFVVDLADNGLNGYHLAMTGDYDLIILDIMLPDVNGWDIVRMLRSANKGMPILLLTA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157  81 RAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRR-NQGLGKDIISYGNLDFDRKSCTVTIAKELIDLKQREFRLLE 159
Cdd:PRK09836  81 LGTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRgAAVIIESQFQVADLMVDLVSRKVTRSGTRITLTSKEFTLLE 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 658757157 160 IFLTHQGKVLNKDELLDHLYSFDDSPSPNAIETYVARLRKKLVNSSVD--IKTLRGLGYLLAEPNE 223
Cdd:PRK09836 161 FFLRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKRLRGKIDNDFEPklIQTVRGVGYMLEVPDG 226
PhoB TIGR02154
phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response ...
 2-218 3.46e-37

phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response regulator protein acting with PhoR in a 2-component system responding to phosphate ion. PhoB acts as a positive regulator of gene expression for phosphate-related genes such as phoA, phoS, phoE and ugpAB as well as itself. It is often found proximal to genes for the high-affinity phosphate ABC transporter (pstSCAB; GenProp0190) and presumably regulates these as well. [Regulatory functions, DNA interactions, Signal transduction, Two-component systems]


Pssm-ID: 131209 [Multi-domain]  Cd Length: 226  Bit Score: 129.37  E-value: 3.46e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157    2 RILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSS--NTPVLILT 79
Cdd:TIGR02154   4 RILVVEDEPAIRELIAYNLEKAGYDVVEAGDGDEALTLINERGPDLILLDWMLPGTSGIELCRRLRRRPEtrAIPIIMLT 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   80 ARAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRR-NQGLGKDIISYGNLDFDRKSCTVTIAKELIDLKQREFRLL 158
Cdd:TIGR02154  84 ARGEEEDRVRGLETGADDYITKPFSPRELLARIKAVLRRiRPQLSDEVIEVGDLSLDPVAHRVFRGGQPLSLGPTEFRLL 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 658757157  159 EIFLTHQGKVLNKDELLDHLYSFDDSPSPNAIETYVARLRKKLVNSSVD--IKTLRGLGYLL 218
Cdd:TIGR02154 164 HFFMTHPERVYSREQLLDRVWGRDVYVEERTVDVHIRRLRKALNPFGLEdpVQTVRGAGYRF 225
cztR_silR_copR TIGR01387
heavy metal response regulator; Members of this family contain a response regulator receiver ...
 3-218 1.90e-36

heavy metal response regulator; Members of this family contain a response regulator receiver domain (pfam00072) and an associated transcriptional regulatory region (pfam00486). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc. Most members encoded by genes adjacent to genes for encoding a member of the heavy metal sensor histidine kinase family (TIGRFAMs:TIGR01386), its partner in the two-component response regulator system. [Regulatory functions, DNA interactions]


Pssm-ID: 130454 [Multi-domain]  Cd Length: 218  Bit Score: 127.22  E-value: 1.90e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157    3 ILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILTARA 82
Cdd:TIGR01387   1 ILVVEDEQKTAEYLQQGLSESGYVVDAASNGRDGLHLALKDDYDLIILDVMLPGMDGWQILQTLRRSGKQTPVLFLTARD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   83 QVEHRIELLDLGADDYLTKPFDFGELEARCRALLRRNQGLGKDIISYGNLDFDRKSCTVTIAKELIDLKQREFRLLEIFL 162
Cdd:TIGR01387  81 SVADKVKGLDLGADDYLVKPFSFSELLARVRTLLRRSHSLNSTVLEIADLRMDSVRHRVSRGNIRITLTRKEFQLLWLLM 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 658757157  163 THQGKVLNKDELLDHLYSFDDSPSPNAIETYVARLRKKLVNSSVD--IKTLRGLGYLL 218
Cdd:TIGR01387 161 RRTGEVLPRTVIASLVWGMNFDSDTNVVDVAIRRLRAKVDDPFEEklIHTIRGMGYVL 218
PRK10816 PRK10816
two-component system response regulator PhoP;
1-216 1.11e-34

two-component system response regulator PhoP;


Pssm-ID: 182755 [Multi-domain]  Cd Length: 223  Bit Score: 122.93  E-value: 1.11e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   1 MRILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILTA 80
Cdd:PRK10816   1 MRVLVVEDNALLRHHLKVQLQDAGHQVDAAEDAKEADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSNDVSLPILVLTA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157  81 RAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRRNQGLGKDIISYGNLDFDRKSCTVTIAKELIDLKQREFRLLEI 160
Cdd:PRK10816  81 RESWQDKVEVLSAGADDYVTKPFHIEEVMARMQALMRRNSGLASQVISLPPFQVDLSRRELSINDEVIKLTAFEYTIMET 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 658757157 161 FLTHQGKVLNKDELLDHLYSFDDSPSPNAIETYVARLRKKLVNSSVD--IKTLRGLGY 216
Cdd:PRK10816 161 LIRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAQYPQevITTVRGQGY 218
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 3-117 1.33e-30

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 109.11  E-value: 1.33e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   3 ILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILTARA 82
Cdd:cd17624    1 ILLVEDDALLGDGLKTGLRKAGYAVDWVRTGAEAEAALASGPYDLVILDLGLPDGDGLDLLRRWRRQGQSLPVLILTARD 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 658757157  83 QVEHRIELLDLGADDYLTKPFDFGELEARCRALLR 117
Cdd:cd17624   81 GVDDRVAGLDAGADDYLVKPFALEELLARLRALLR 115
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
2-216 7.65e-30

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 110.58  E-value: 7.65e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   2 RILAVEDDEVLGEAICqrFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGE--QILKKLR--ARSSNTPVLI 77
Cdd:PRK10161   4 RILVVEDEAPIREMVC--FVLEQNGFQPVEAEDYDSAVNQLNEPWPDLILLDWMLPGGSgiQFIKHLKreSMTRDIPVVM 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157  78 LTARAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRRNQGLG-KDIISYGNLDFDRKSCTVTIAKELIDLKQREFR 156
Cdd:PRK10161  82 LTARGEEEDRVRGLETGADDYITKPFSPKELVARIKAVMRRISPMAvEEVIEMQGLSLDPTSHRVMAGEEPLEMGPTEFK 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 658757157 157 LLEIFLTHQGKVLNKDELLDHLYSFDDSPSPNAIETYVARLRKKLVNSSVD--IKTLRGLGY 216
Cdd:PRK10161 162 LLHFFMTHPERVYSREQLLNHVWGTNVYVEDRTVDVHIRRLRKALEPGGHDrmVQTVRGTGY 223
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 4-118 1.65e-29

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 106.15  E-value: 1.65e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   4 LAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILTARAQ 83
Cdd:cd17625    1 LVVEDEKDLSEAITKHLKKEGYTVDVCFDGEEGLEYALSGIYDLIILDIMLPGMDGLEVLKSLREEGIETPVLLLTALDA 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 658757157  84 VEHRIELLDLGADDYLTKPFDFGELEARCRALLRR 118
Cdd:cd17625   81 VEDRVKGLDLGADDYLPKPFSLAELLARIRALLRR 115
PRK11517 PRK11517
DNA-binding response regulator HprR;
1-221 1.70e-29

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 109.60  E-value: 1.70e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   1 MRILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRArSSNTPVLILTA 80
Cdd:PRK11517   1 MKILLIEDNQRTQEWVTQGLSEAGYVIDAVSDGRDGLYLALKDDYALIILDIMLPGMDGWQILQTLRT-AKQTPVICLTA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157  81 RAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRRNQGLGKDIISYGnLDFDRKSCTVTIAKELIDLKQREFRLLEI 160
Cdd:PRK11517  80 RDSVDDRVRGLDSGANDYLVKPFSFSELLARVRAQLRQHHALNSTLEISG-LRMDSVSQSVSRDNISITLTRKEFQLLWL 158

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 658757157 161 FLTHQGKVLNKDELLDHLYSFDDSPSPNAIETYVARLRKKlVNSSVDIK---TLRGLGYLLAEP 221
Cdd:PRK11517 159 LASRAGEIIPRTVIASEIWGINFDSDTNTVDVAIRRLRAK-VDDPFPEKliaTIRGMGYSFVAV 221
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 64-219 1.12e-27

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 104.66  E-value: 1.12e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157  64 KKLRARSSNTPVLILTARAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRRNQG--LGKDIISYGNLDFDRKSCTV 141
Cdd:PRK11083  67 RQLLAFHPALPVIFLTARSDEVDRLVGLEIGADDYVAKPFSPREVAARVRTILRRVKKfaAPSPVIRIGHFELDEPAARI 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157 142 TIAKELIDLKQREFRLLEIFLTHQGKVLNKDELLDHLYSFDDSPSPNAIETYVARLRKKL--VNSSVD-IKTLRGLGYLL 218
Cdd:PRK11083 147 SYFGTPLTLTRYEFLLLKTLLLSPGRVFSRQQLMDIVWEDAQDSYDRTVDTHIKTLRAKLraINPDLSpINTHRGMGYSL 226


                 .
gi 658757157 219 A 219
Cdd:PRK11083 227 R 227
orf27 CHL00148
Ycf27; Reviewed
 1-217 1.31e-27

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 105.18  E-value: 1.31e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   1 MRILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRaRSSNTPVLILTA 80
Cdd:CHL00148   7 EKILVVDDEAYIRKILETRLSIIGYEVITASDGEEALKLFRKEQPDLVILDVMMPKLDGYGVCQEIR-KESDVPIIMLTA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157  81 RAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRRNQGLG-------KDIISYGNLDFDRKSCTVTIAKELIDLKQR 153
Cdd:CHL00148  86 LGDVSDRITGLELGADDYVVKPFSPKELEARIRSVLRRTNKKSfsskipnSSIIRIGFLKIDLNKKQVYKNNERIRLTGM 165

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 658757157 154 EFRLLEIFLTHQGKVLNKDELLDHL--YSFDDSPSPNAIETYVARLRKKLVNSSVD---IKTLRGLGYL 217
Cdd:CHL00148 166 EFSLLELLISKSGEIFSRATILKEVwgYTPERHIDTRVVDVHISRLRAKLEDDPSNpdlILTARGTGYL 234
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 3-119 3.12e-24

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 92.73  E-value: 3.12e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   3 ILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILTARA 82
Cdd:cd19934    1 LLLVEDDALLAAQLKEQLSDAGYVVDVAEDGEEALFQGEEEPYDLVVLDLGLPGMDGLSVLRRWRSEGRATPVLILTARD 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 658757157  83 QVEHRIELLDLGADDYLTKPFDFGELEARCRALLRRN 119
Cdd:cd19934   81 SWQDKVEGLDAGADDYLTKPFHIEELLARLRALIRRA 117
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 59-201 3.68e-24

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 95.64  E-value: 3.68e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157  59 GEQILKKLRARSSnTPVLILTARAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRRNQGLGKD--IISYGNLDFDR 136
Cdd:PRK10529  60 GIEFIRDLRQWSA-IPVIVLSARSEESDKIAALDAGADDYLSKPFGIGELQARLRVALRRHSATPAPdpLVKFSDVTVDL 138

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 658757157 137 KSCTVTIAKELIDLKQREFRLLEIFLTHQGKVLNKDELLDHLYsfddspSPNAIE------TYVARLRKKL 201
Cdd:PRK10529 139 AARVIHRGEEEVHLTPIEFRLLAVLLNNAGKVLTQRQLLNQVW------GPNAVEhshylrIYMGHLRQKL 203
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 132-218 4.91e-24

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 91.39  E-value: 4.91e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157 132 LDFDRKSCTVTIAKELIDLKQREFRLLEIFLTHQGKVLNKDELLDHLYSFDDSPSPNAIETYVARLRKKL--VNSSVDIK 209
Cdd:cd00383    1 LRLDPARREVTVDGEEVELTPKEFELLELLARNPGRVVSREELLEAVWGYDYEVDDRTVDVHISRLRKKLedDPEPRLIK 80


                 ....*....
gi 658757157 210 TLRGLGYLL 218
Cdd:cd00383   81 TVRGVGYRL 89
MtrAB_MtrA NF040689
MtrAB system response regulator MtrA;
59-216 3.80e-23

MtrAB system response regulator MtrA;


Pssm-ID: 468653 [Multi-domain]  Cd Length: 219  Bit Score: 92.62  E-value: 3.80e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157  59 GEQILKKLRArSSNTPVLILTARAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRRNQGLGKDIISYGNLDFDRKS 138
Cdd:NF040689  57 GIEVCRQIRA-ESGVPIIMLTAKSDTVDVVRGLEAGADDYVVKPFKPKELVARIRARLRRSEDEESEVLRIGDLTIDVAG 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157 139 CTVTIAKELIDLKQREFRLLEIFLTHQGKVLNKDELLDHLYSFDDSPSPNAIETYVARLRKKLV----NSSVdIKTLRGL 214
Cdd:NF040689 136 HEVTRGGEEIPLTPLEFDLLVALARKPGQVFSREELLEQVWGYRHAADTRLVNVHVQRLRAKIErdpeNPEI-VVTVRGV 214


                 ..
gi 658757157 215 GY 216
Cdd:NF040689 215 GY 216
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 3-102 6.21e-23

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 88.65  E-value: 6.21e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   3 ILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILTARA 82
Cdd:cd19935    1 ILVVEDEKKLAEYLKKGLTEEGYAVDVAYDGEDGLHLALTNEYDLIILDVMLPGLDGLEVLRRLRAAGKQTPVLMLTARD 80

                         90       100
                 ....*....|....*....|
gi 658757157  83 QVEHRIELLDLGADDYLTKP 102
Cdd:cd19935   81 SVEDRVKGLDLGADDYLVKP 100
ompR PRK09468
osmolarity response regulator; Provisional
 2-216 7.23e-23

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 92.34  E-value: 7.23e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   2 RILAVEDDEVLgEAICQRFTkMGQGIDLVTSGDVA--NSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILT 79
Cdd:PRK09468   7 KILVVDDDMRL-RALLERYL-TEQGFQVRSAANAEqmDRLLTRESFHLMVLDLMLPGEDGLSICRRLRSQNNPTPIIMLT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157  80 ARAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRR--NQGLG-----KDIISYGNLDFDRKSCTVTIAKELIDLKQ 152
Cdd:PRK09468  85 AKGEEVDRIVGLEIGADDYLPKPFNPRELLARIRAVLRRqaPELPGapsqeEEVIAFGKFKLNLGTRELFRGDEPMPLTT 164

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 658757157 153 REFRLLEIFLTHQGKVLNKDELLDHLYSFDDSPSPNAIETYVARLRKKL-VNSSVD--IKTLRGLGY 216
Cdd:PRK09468 165 GEFAVLKALVSHPREPLSRDKLMNLARGREYSAMERSIDVQISRLRRLIeEDPAHPryIQTVWGLGY 231
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
2-218 5.76e-22

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 89.86  E-value: 5.76e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   2 RILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKrHEYDLILLDLNLPNLNGEQILKKLRaRSSNTPVLILTAR 81
Cdd:PRK10955   3 KILLVDDDRELTSLLKELLEMEGFNVIVAHDGEQALDLLD-DSIDLLLLDVMMPKKNGIDTLKELR-QTHQTPVIMLTAR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157  82 AQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRR--------NQGLGKDIISYGNLDFDRKSCTVTIAKELIDLKQR 153
Cdd:PRK10955  81 GSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRshwseqqqNNDNGSPTLEVDALSLNPGRQEASFDGQTLELTGT 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 658757157 154 EFRLLEIFLTHQGKVLNKDELLDHLYSFDDSPSPNAIETYVARLRKKLVNSSVD---IKTLRGLGYLL 218
Cdd:PRK10955 161 EFTLLYLLAQHLGQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRRKLPDRKDGhpwFKTLRGRGYLM 228
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 146-218 2.54e-21

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 83.76  E-value: 2.54e-21
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 658757157   146 ELIDLKQREFRLLEIFLTHQGKVLNKDELLDHLYSFDDSPSPNAIETYVARLRKKL--VNSSVDIKTLRGLGYLL 218
Cdd:smart00862   2 EPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDEDVDDNTLDVHISRLRKKLedDGDPRLIETVRGVGYRL 76
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
146-218 9.74e-21

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 82.18  E-value: 9.74e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 658757157  146 ELIDLKQREFRLLEIFLTHQGKVLNKDELLDHLYSFDDSPSPNAIETYVARLRKKL---VNSSVDIKTLRGLGYLL 218
Cdd:pfam00486   2 EEVELTPKEFKLLELLAENPGRVVSREQLLEEVWGEDYDVDDNTVDVHISRLRKKLeddPRDPRLIKTVRGVGYRL 77
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 2-216 1.89e-20

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 85.89  E-value: 1.89e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   2 RILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRaRSSNTPVLILTAR 81
Cdd:PRK10710  12 RILIVEDEPKLGQLLIDYLQAASYATTLLSHGDEVLPYVRQTPPDLILLDLMLPGTDGLTLCREIR-RFSDIPIVMVTAK 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157  82 AQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRR--NQGLGKDIISYGNLDFDRKSCTVTIAKELIDLKQREFRLLE 159
Cdd:PRK10710  91 IEEIDRLLGLEIGADDYICKPYSPREVVARVKTILRRckPQRELQQQDAESPLIIDESRFQASWRGKMLDLTPAEFRLLK 170

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 658757157 160 IFLTHQGKVLNKDELLDHLYsfDDSP--SPNAIETYVARLRKKLVNSSVD---IKTLRGLGY 216
Cdd:PRK10710 171 TLSHEPGKVFSREQLLNHLY--DDYRvvTDRTIDSHIKNLRRKLESLDAEqsfIRAVYGVGY 230
resp_reg_YycF NF040534
response regulator YycF;
59-221 5.86e-20

response regulator YycF;


Pssm-ID: 439744 [Multi-domain]  Cd Length: 231  Bit Score: 84.39  E-value: 5.86e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157  59 GEQILKKLRaRSSNTPVLILTARAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRRNQGLGKD-------IISYGN 131
Cdd:NF040534  59 GMEVCREVR-KKYDMPIIMLTAKDSEIDKVLGLELGADDYVTKPFSTRELIARVKANLRRHQQQNTEeeeeennEIVIGS 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157 132 LDFDRKSCTVTIAKELIDLKQREFRLLEIFLTHQGKVLNKDELLDHLYSFDDSPSPNAIETYVARLRKKLVNSSVD---I 208
Cdd:NF040534 138 LTIHPDAYTVKKRGETIELTHREFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHpewI 217

                        170
                 ....*....|...
gi 658757157 209 KTLRGLGYLLAEP 221
Cdd:NF040534 218 VTRRGVGYYLRNP 230
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 1-120 1.74e-18

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 83.09  E-value: 1.74e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   1 MRILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILTA 80
Cdd:COG2204    3 ARILVVDDDPDIRRLLKELLERAGYEVETAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVILLTG 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 658757157  81 RAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRRNQ 120
Cdd:COG2204   83 YGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERALERRR 122
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 4-102 2.76e-18

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 76.68  E-value: 2.76e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   4 LAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILTARAQ 83
Cdd:cd17574    1 LVVEDDEEIAELLSDYLEKEGYEVDTAADGEEALELAREEQPDLIILDVMLPGMDGFEVCRRLREKGSDIPIIMLTAKDE 80

                         90
                 ....*....|....*....
gi 658757157  84 VEHRIELLDLGADDYLTKP 102
Cdd:cd17574   81 EEDKVLGLELGADDYITKP 99
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 3-111 3.12e-18

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 76.81  E-value: 3.12e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157    3 ILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILTARA 82
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTAHG 80

                          90       100
                  ....*....|....*....|....*....
gi 658757157   83 QVEHRIELLDLGADDYLTKPFDFGELEAR 111
Cdd:pfam00072  81 DEDDAVEALEAGADDFLSKPFDPDELLAA 109
PRK10766 PRK10766
two-component system response regulator TorR;
2-201 1.05e-17

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 78.16  E-value: 1.05e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   2 RILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSsNTPVLILTAR 81
Cdd:PRK10766   4 HILVVEDEPVTRARLQGYFEQEGYTVSEAASGAGMREIMQNQHVDLILLDINLPGEDGLMLTRELRSRS-TVGIILVTGR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157  82 AQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRR----NQGLGK-----DIISYGNLDFDRKSCTVTIAKELIDLKQ 152
Cdd:PRK10766  83 TDSIDRIVGLEMGADDYVTKPLELRELLVRVKNLLWRislaRQAQPHaqeedNCYRFAGYCLNVSRRTLERNGEPIKLTK 162

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 658757157 153 REFRLLEIFLTHQGKVLNKDELLDHLYSFDDSPSPNAIETYVARLRKKL 201
Cdd:PRK10766 163 AEYELLVAFVTNPGQVLSRERLLRMLSHRVENPNDRTIDVLIRRLRHKL 211
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 59-118 2.50e-17

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 74.73  E-value: 2.50e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157  59 GEQILKKLRARSSNTPVLILTARAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRR 118
Cdd:cd17627   57 GLEVCRRLRAAGNDLPILVLTARDSVSDRVAGLDAGADDYLVKPFALEELLARVRALLRR 116
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 3-118 3.52e-17

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 74.26  E-value: 3.52e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   3 ILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSsNTPVLILTARA 82
Cdd:cd17623    1 ILLIDDDRELTELLTEYLEMEGFNVRAAHDGEQGLAALLEGSPDLVVLDVMLPKMNGLDVLKELRKTS-QVPVLMLTARG 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 658757157  83 QVEHRIELLDLGADDYLTKPFDFGELEARCRALLRR 118
Cdd:cd17623   80 DDIDRILGLELGADDYLPKPFNPRELVARIRAILRR 115
PRK10701 PRK10701
DNA-binding transcriptional regulator RstA; Provisional
 2-219 9.52e-17

DNA-binding transcriptional regulator RstA; Provisional


Pssm-ID: 236738 [Multi-domain]  Cd Length: 240  Bit Score: 76.21  E-value: 9.52e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   2 RILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNtPVLILTAR 81
Cdd:PRK10701   3 KIVFVEDDAEVGSLIAAYLAKHDIDVTVEPRGDRAEATILREQPDLVLLDIMLPGKDGMTICRDLRPKWQG-PIVLLTSL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157  82 AQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRRN------------QGLGKDIISYGNLDFDRKSCTVTIAKELID 149
Cdd:PRK10701  82 DSDMNHILALEMGACDYILKTTPPAVLLARLRLHLRQNeqatqtkglqetSLTPYKALHFGTLTIDPVNRQVTLAGEEIS 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 658757157 150 LKQREFRLLEIFLTHQGKVLNKDELLDHLYSFDDSPSPNAIETYVARLRKKLVNSSVD---IKTLRGLGYLLA 219
Cdd:PRK10701 162 LSTADFDLLWELATHAGQIMDRDALLKNLRGVSYDGLDRSVDVAISRLRKKLLDNAAEpyrIKTVRNKGYLFA 234
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 2-116 1.35e-16

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 72.67  E-value: 1.35e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   2 RILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARS--SNTPVLILT 79
Cdd:cd17618    2 TILIVEDEPAIREMIAFNLERAGFDVVEAEDAESAVNLIVEPRPDLILLDWMLPGGSGIQFIRRLKRDEmtRDIPIIMLT 81

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 658757157  80 ARAQVEHRIELLDLGADDYLTKPFDFGELEARCRALL 116
Cdd:cd17618   82 ARGEEEDKVRGLEAGADDYITKPFSPRELVARIKAVL 118
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 59-118 2.52e-16

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 72.00  E-value: 2.52e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157  59 GEQILKKLRARSSNTPVLILTARAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRR 118
Cdd:cd17615   58 GLEVLRRLRADGPDVPVLFLTAKDSVEDRIAGLTAGGDDYVTKPFSLEEVVARLRALLRR 117
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 1-120 3.07e-16

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 74.43  E-value: 3.07e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   1 MRILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSS--NTPVLIL 78
Cdd:COG3437    7 PTVLIVDDDPENLELLRQLLRTLGYDVVTAESGEEALELLLEAPPDLILLDVRMPGMDGFELLRLLRADPStrDIPVIFL 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 658757157  79 TARAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRRNQ 120
Cdd:COG3437   87 TALADPEDRERALEAGADDYLTKPFDPEELLARVRNALELRR 128
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 1-111 4.54e-16

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 73.02  E-value: 4.54e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   1 MRILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRA--RSSNTPVLIL 78
Cdd:COG3706    2 ARILVVDDDPTNRKLLRRLLEAAGYEVVEAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLRAdpRTADIPIIFL 81

                         90       100       110
                 ....*....|....*....|....*....|...
gi 658757157  79 TARAQVEHRIELLDLGADDYLTKPFDFGELEAR 111
Cdd:COG3706   82 TALDDEEDRARALEAGADDYLTKPFDPEELLAR 114
CadC1 COG3710
DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];
130-221 1.42e-15

DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];


Pssm-ID: 442924 [Multi-domain]  Cd Length: 106  Bit Score: 69.55  E-value: 1.42e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157 130 GNLDFDRKSCTVTIAKELIDLKQREFRLLEIFLTHQGKVLNKDELLDHLYSfDDSPSPNAIETYVARLRKKLVNSSVD-- 207
Cdd:COG3710    6 GDFRLDPARRELLRDGEPVRLSPRAFDLLLLLLEHPGRVVSRDELLAAVWP-GRVVSDNSLTQAISRLRKALGDDGLEpr 84

                         90
                 ....*....|....*
gi 658757157 208 -IKTLRGLGYLLAEP 221
Cdd:COG3710   85 lIRTVPRRGYRLVAP 99
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 1-121 4.02e-15

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 69.11  E-value: 4.02e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   1 MRILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARS--SNTPVLIL 78
Cdd:COG0784    6 KRILVVDDNPDNRELLRRLLERLGYEVTTAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIRALPrlPDIPIIAL 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 658757157  79 TARAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRRNQG 121
Cdd:COG0784   86 TAYADEEDRERALEAGADDYLTKPVDPEELLEALRRLLARASA 128
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 3-116 7.35e-15

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 68.20  E-value: 7.35e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   3 ILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILTARA 82
Cdd:cd17616    1 VLLIEDDSATAQSIELMLKSEGFNVYTTDLGEEGLDLGKLYDYDIILLDLNLPDMSGYEVLRTLRLAKVKTPILILSGLA 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 658757157  83 QVEHRIELLDLGADDYLTKPFDFGELEARCRALL 116
Cdd:cd17616   81 DIEDKVKGLGFGADDYMTKPFHKDELVARIHAIV 114
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 4-117 2.31e-13

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 64.22  E-value: 2.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   4 LAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLR--ARSSNTPVLILTAR 81
Cdd:cd19937    1 LVVDDEEDIVELLKYNLEKEGYEVVTAYDGEEALKRAKDEKPDLIILDLMLPGIDGLEVCRILRsdPKTSSIPIIMLTAK 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 658757157  82 AQVEHRIELLDLGADDYLTKPFDFGELEARCRALLR 117
Cdd:cd19937   81 GEEFDKVLGLELGADDYITKPFSPRELLARVKAVLR 116
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 1-113 2.00e-12

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 61.69  E-value: 2.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   1 MRILAVeDDEVLGEAICQRFTKMGQGIDLVTSGD--VANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNT--PVL 76
Cdd:cd17551    1 MRILIV-DDNPTNLLLLEALLRSAGYLEVVSFTDprEALAWCRENPPDLILLDYMMPGMDGLEFIRRLRALPGLEdvPIV 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 658757157  77 ILTARAQVEHRIELLDLGADDYLTKPFDFGELEARCR 113
Cdd:cd17551   80 MITADTDREVRLRALEAGATDFLTKPFDPVELLARVR 116
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 2-118 2.24e-12

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 61.62  E-value: 2.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   2 RILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSnTPVLILTAR 81
Cdd:cd19939    1 RILIVEDELELARLTRDYLIKAGLEVSVFTDGQRAVRRIIDEQPSLVVLDIMLPGMDGLTVCREVREHSH-VPILMLTAR 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 658757157  82 AQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRR 118
Cdd:cd19939   80 TEEMDRVLGLEMGADDYLCKPFSPRELLARVRALLRR 116
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 2-117 2.69e-12

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 61.24  E-value: 2.69e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   2 RILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRaRSSNTPVLILTAR 81
Cdd:cd17622    2 RILLVEDDPKLARLIADFLESHGFNVVVEHRGDRALEVIAREKPDAVLLDIMLPGIDGLTLCRDLR-PKYQGPILLLTAL 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 658757157  82 AQVEHRIELLDLGADDYLTKPFDFGELEARCRALLR 117
Cdd:cd17622   81 DSDIDHILGLELGADDYVVKPVEPAVLLARLRALLR 116
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-125 3.39e-12

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 61.52  E-value: 3.39e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   1 MRILAVEDDEVLGEaICQRFTKMGQG---IDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLI 77
Cdd:COG4565    4 IRVLIVEDDPMVAE-LLRRYLERLPGfevVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRARGPDVDVIV 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 658757157  78 LTARAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRRNQGLGKD 125
Cdd:COG4565   83 ITAARDPETVREALRAGVVDYLIKPFTFERLREALERYLEYRRLLRED 130
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 4-102 4.61e-12

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 60.32  E-value: 4.61e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   4 LAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILTARAQ 83
Cdd:cd00156    1 LIVDDDPAIRELLKSLLEREGYEVDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVLTAKAD 80

                         90
                 ....*....|....*....
gi 658757157  84 VEHRIELLDLGADDYLTKP 102
Cdd:cd00156   81 EEDAVRALELGADDYLVKP 99
PRK11173 PRK11173
two-component response regulator; Provisional
 64-216 4.65e-12

two-component response regulator; Provisional


Pssm-ID: 183013 [Multi-domain]  Cd Length: 237  Bit Score: 63.11  E-value: 4.65e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157  64 KKLRARSsNTPVLILTARAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRRNQGLG------KDIISYG----NLD 133
Cdd:PRK11173  67 RELREQA-NVALMFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRTMNLGtvseerRSVESYKfngwELD 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157 134 FDRKScTVTIAKELIDLKQREFRLLEIFLTHQGKVLNKDELLDHLYSFDDSPSPNAIETYVARLRKKLvNSSVD----IK 209
Cdd:PRK11173 146 INSRS-LISPDGEQYKLPRSEFRAMLHFCENPGKIQSRAELLKKMTGRELKPHDRTVDVTIRRIRKHF-ESTPDtpeiIA 223


                 ....*..
gi 658757157 210 TLRGLGY 216
Cdd:PRK11173 224 TIHGEGY 230
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 59-102 8.08e-12

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 59.49  E-value: 8.08e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 658757157  59 GEQILKKLRaRSSNTPVLILTARAQVEHRIELLDLGADDYLTKP 102
Cdd:cd17620   57 GLEVIRRLR-EWSAVPVIVLSARDEESDKIAALDAGADDYLTKP 99
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 2-114 1.17e-11

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 61.09  E-value: 1.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   2 RILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILTAR 81
Cdd:COG4567    6 SLLLVDDDEAFARVLARALERRGFEVTTAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDPDARIVVLTGY 85

                         90       100       110
                 ....*....|....*....|....*....|...
gi 658757157  82 AQVEHRIELLDLGADDYLTKPFDFGELEARCRA 114
Cdd:COG4567   86 ASIATAVEAIKLGADDYLAKPADADDLLAALER 118
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
2-128 1.33e-11

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 62.94  E-value: 1.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   2 RILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILTAR 81
Cdd:PRK11361   6 RILIVDDEDNVRRMLSTAFALQGFETHCANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRTPVILMTAY 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 658757157  82 AQVEHRIELLDLGADDYLTKPFDFGELearcRALLRRN---QGLGKDIIS 128
Cdd:PRK11361  86 AEVETAVEALRCGAFDYVIKPFDLDEL----NLIVQRAlqlQSMKKEIRH 131
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 2-116 3.09e-11

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 58.54  E-value: 3.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   2 RILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRaRSSNTPVLILTAR 81
Cdd:cd19938    1 RILIVEDEPKLAQLLIDYLRAAGYAPTLLAHGDQVLPYVRHTPPDLILLDLMLPGTDGLTLCREIR-RFSDVPIIMVTAR 79

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 658757157  82 AQVEHRIELLDLGADDYLTKPFDFGELEARCRALL 116
Cdd:cd19938   80 VEEIDRLLGLELGADDYICKPYSPREVVARVKAIL 114
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 3-110 7.36e-11

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 57.48  E-value: 7.36e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   3 ILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRA---RSSNTPVLILT 79
Cdd:cd17546    1 VLVVDDNPVNRKVLKKLLEKLGYEVDVAENGQEALELLKEEPFDLVLMDLQMPVMDGLEATRRIRElegGGRRTPIIALT 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 658757157  80 ARAQVEHRIELLDLGADDYLTKPFDFGELEA 110
Cdd:cd17546   81 ANALEEDREKCLEAGMDDYLSKPVKLDQLKE 111
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 3-118 8.99e-11

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 57.05  E-value: 8.99e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   3 ILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSsNTPVLILTARA 82
Cdd:cd17614    1 ILVVDDEKPISDILKFNLTKEGYEVVTAYDGREALEKVEEEQPDLILLDLMLPEKDGLEVCREVRKTS-NVPIIMLTAKD 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 658757157  83 QVEHRIELLDLGADDYLTKPFDFGELEARCRALLRR 118
Cdd:cd17614   80 SEVDKVLGLELGADDYVTKPFSNRELLARVKANLRR 115
REC_HP-RR-like cd17573
phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; ...
 3-111 1.76e-10

phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; Helicobacter pylori response regulator hp1043 (HP-RR) is an orphan response regulator which is phosphorylation-independent and is essential for growth. HP-RR functions as a cell growth-associated regulator in the absence of post-translational modification. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381115 [Multi-domain]  Cd Length: 110  Bit Score: 56.28  E-value: 1.76e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   3 ILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILTARA 82
Cdd:cd17573    1 ILLIEDDSTLGKEISKGLNEKGYQADVAESLKDGEYYIDIRNYDLVLVSDKLPDGNGLSIVSRIKEKHPSIVVIVLSDNP 80

                         90       100
                 ....*....|....*....|....*....
gi 658757157  83 QVEHRIELLDLGADDYLTKPFDFGELEAR 111
Cdd:cd17573   81 KTEQEIEAFKEGADDYIAKPFDFKVLVAR 109
PRK13856 PRK13856
two-component response regulator VirG; Provisional
 59-218 3.23e-10

two-component response regulator VirG; Provisional


Pssm-ID: 172377 [Multi-domain]  Cd Length: 241  Bit Score: 57.90  E-value: 3.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157  59 GEQILKKLRARSSNTPVLILTARAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRR--NQGLGKDIISYG----NL 132
Cdd:PRK13856  60 GLEIVRSLATKSDVPIIIISGDRLEEADKVVALELGATDFIAKPFGTREFLARIRVALRVrpNVVRTKDRRSFCfadwTL 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157 133 DFDRKSCTVTIAKElIDLKQREFRLLEIFLTHQGKVLNKDELLDHLYSFDDSPSPNAIETYVARLRKKLVNSSVD---IK 209
Cdd:PRK13856 140 NLRQRRLISEAGGE-VKLTAGEFNLLVAFLEKPRDVLSREQLLIASRVREEEVYDRSIDVLILRLRRKLEQDPANpqlIK 218


                 ....*....
gi 658757157 210 TLRGLGYLL 218
Cdd:PRK13856 219 TARGAGYFF 227
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 3-114 8.19e-10

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 54.37  E-value: 8.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   3 ILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSsNTPVLILTARA 82
Cdd:cd17594    2 VLVVDDDAAMRHLLILYLRERGFDVTAAADGAEEARLMLHRRVDLVLLDLRLGQESGLDLLRTIRARS-DVPIIIISGDR 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 658757157  83 QVE-HRIELLDLGADDYLTKPFDFGELEARCRA 114
Cdd:cd17594   81 RDEiDRVVGLELGADDYLAKPFGLRELLARVRA 113
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 3-102 1.74e-09

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 53.54  E-value: 1.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   3 ILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLR--ARSSNTPVLILTA 80
Cdd:cd19927    1 ILLVDDDPGIRLAVKDYLEDQGFTVIAASNGLEALDLLNQYIPDLIISDIIMPGVDGYSLLGKLRknADFDTIPVIFLTA 80

                         90       100
                 ....*....|....*....|..
gi 658757157  81 RAQVEHRIELLDLGADDYLTKP 102
Cdd:cd19927   81 KGMTSDRIKGYNAGCDGYLSKP 102
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 2-116 2.04e-09

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 53.63  E-value: 2.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   2 RILAVEDDEVLGEAICqrFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPN--LNGEQILKKLRARSSnTPVLILT 79
Cdd:cd17626    2 RILVVDDDAALAEMIG--IVLRGEGFDPAFCGDGTQALAAFREVRPDLVLLDLMLpgIDGIEVCRQIRAESG-VPIVMLT 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 658757157  80 ARAQVEHRIELLDLGADDYLTKPFDFGELEARCRALL 116
Cdd:cd17626   79 AKSDTVDVVLGLESGADDYVAKPFKPKELVARIRARL 115
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
 3-102 2.25e-09

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 52.97  E-value: 2.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   3 ILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARsSNTPVLILTARA 82
Cdd:cd17621    1 VLVVEDEESFSDPLAYLLRKEGFEVTVATDGPAALAEFDRAGADIVLLDLMLPGLSGTEVCRQLRAR-SNVPVIMVTAKD 79

                         90       100
                 ....*....|....*....|
gi 658757157  83 QVEHRIELLDLGADDYLTKP 102
Cdd:cd17621   80 SEIDKVVGLELGADDYVTKP 99
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 2-113 3.85e-09

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 52.77  E-value: 3.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   2 RILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARsSNTPVLILTAR 81
Cdd:cd17619    2 HILIVEDEPVTRATLKSYFEQEGYDVSEAGDGEEMRQILARQDIDLVLLDINLPGKDGLSLTRELREQ-SEVGIILVTGR 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 658757157  82 AQVEHRIELLDLGADDYLTKPFDFGELEARCR 113
Cdd:cd17619   81 DDEVDRIVGLEIGADDYVTKPFNPRELLVRAK 112
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 1-110 1.13e-08

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 51.29  E-value: 1.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   1 MRILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILTA 80
Cdd:cd17563    1 KSLLLVDDDEVFAERLARALERRGFEVETAHSVEEALALAREEKPDYAVLDLRLGGDSGLDLIPPLRALQPDARIVVLTG 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 658757157  81 RAQVEHRIELLDLGADDYLTKPFDFGELEA 110
Cdd:cd17563   81 YASIATAVEAIKLGADDYLAKPADADEILA 110
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
3-126 2.92e-08

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 53.11  E-value: 2.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   3 ILAVEDDeVLGEAICQRFTK-MGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILTAR 81
Cdd:PRK10365   8 ILVVDDD-ISHCTILQALLRgWGYNVALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNPAIPVLIMTAY 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 658757157  82 AQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRRNQGLGKDI 126
Cdd:PRK10365  87 SSVETAVEALKTGALDYLIKPLDFDNLQATLEKALAHTHSIDAET 131
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 3-104 2.99e-08

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 50.27  E-value: 2.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   3 ILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILTARA 82
Cdd:cd17572    1 VLLVEDSPSLAALYQEYLSDEGYKVTHVETGKEALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSLPTSVIVITAHG 80

                         90       100
                 ....*....|....*....|..
gi 658757157  83 QVEHRIELLDLGADDYLTKPFD 104
Cdd:cd17572   81 SVDIAVEAMRLGAYDFLEKPFD 102
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 59-102 1.44e-07

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 48.23  E-value: 1.44e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 658757157  59 GEQILKKLRARSSNTPVLILTARAQVEHRIELLDLGADDYLTKP 102
Cdd:COG4753   60 GLELLEAIRELDPDTKIIILSGYSDFEYAQEAIKLGADDYLLKP 103
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 1-115 4.61e-07

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 46.83  E-value: 4.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   1 MRILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILTA 80
Cdd:cd17554    1 KKILVVDDEENIRELYKEELEDEGYEVVTAGNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIREKKPDLPVIICTA 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 658757157  81 RAqvEHRIELLDLGADDYLTKPFDFGELEARCRAL 115
Cdd:cd17554   81 YS--EYKSDFSSWAADAYVVKSSDLTELKETIKRL 113
pleD PRK09581
response regulator PleD; Reviewed
 64-117 4.29e-06

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 46.82  E-value: 4.29e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 658757157  64 KKLRA--RSSNTPVLILTARAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLR 117
Cdd:PRK09581  66 RRLKSdpATTHIPVVMVTALDDPEDRVRGLEAGADDFLTKPINDVALFARVKSLTR 121
fixJ PRK09390
response regulator FixJ; Provisional
 59-201 4.35e-06

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 45.76  E-value: 4.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157  59 GEQILKKLRARSSNTPVLILTARAQVEHRIELLDLGADDYLTKPFDFGEL-EARCRALLRRNQGLGKDIISygnldfdrk 137
Cdd:PRK09390  62 GIELLRRLKARGSPLPVIVMTGHGDVPLAVEAMKLGAVDFIEKPFEDERLiGAIERALAQAPEAAKSEAVA--------- 132

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 658757157 138 sctVTIAKELIDLKQREFRLLE-IFLTHQGKVLNKDelLDhlysfddsPSPNAIETYVARLRKKL 201
Cdd:PRK09390 133 ---ADIRARIASLSERERQVMDgLVAGLSNKVIARD--LD--------ISPRTVEVYRANVMTKM 184
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 1-103 6.16e-06

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 43.87  E-value: 6.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   1 MRILAVEDDEVLGEAICQRFTKMG-QGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRA--RSSNTPVLI 77
Cdd:cd19923    1 MKVLVVDDFSTMRRIIKNLLKELGfNNVEEAEDGVDALEKLKAGGFDFVITDWNMPNMDGLELLKTIRAdgALSHLPVLM 80

                         90       100
                 ....*....|....*....|....*.
gi 658757157  78 LTARAQVEHRIELLDLGADDYLTKPF 103
Cdd:cd19923   81 VTAEAKKENVIAAAQAGVNNYIVKPF 106
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 59-115 9.43e-06

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 43.42  E-value: 9.43e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 658757157  59 GEQILKKLRARSSNTPVLILTARAQVEHRIELLDLGADDYLTKPFDFGELEARC-RAL 115
Cdd:cd19919   59 GLALLAQIKQRHPDLPVIIMTAHSDLDSAVSAYQGGAFEYLPKPFDIDEAVALVeRAI 116
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
 59-104 1.06e-05

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 43.31  E-value: 1.06e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 658757157  59 GEQILKKLRARSS--NTPVLILTARAQVEHRIELLDLGADDYLTKPFD 104
Cdd:cd17552   61 GLATLKKLQANPEtqSIPVILLTAKAQPSDRQRFASLGVAGVIAKPFD 108
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
 3-116 1.16e-05

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 43.04  E-value: 1.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   3 ILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARsSNTPVLILTARA 82
Cdd:cd18159    1 ILIVEDDETIASLLKKHLEKWGYEVVLIEDFEDVLEEFLQFKPDLVLLDINLPYFDGFYWCREIRQI-SNVPIIFISSRD 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 658757157  83 QVEHRIELLDLGADDYLTKPFDFGELEARCRALL 116
Cdd:cd18159   80 DNMDQVMAINMGGDDYITKPFDLDVLLAKIKAIL 113
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 59-103 1.39e-05

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 42.48  E-value: 1.39e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 658757157  59 GEQILKKLRA--RSSNTPVLILTARAQVEHRIELLDLGADDYLTKPF 103
Cdd:cd17538   58 GFEVCRRLKEdpETRHIPVIMITALDDREDRIRGLEAGADDFLSKPI 104
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 2-111 1.69e-05

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 42.62  E-value: 1.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   2 RILAVEDDEVLGEAICQRFTKMG--QGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILT 79
Cdd:cd19925    2 NVLIVEDDPMVAEIHRAYVEQVPgfTVIGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVIVVT 81

                         90       100       110
                 ....*....|....*....|....*....|..
gi 658757157  80 ARAQVEHRIELLDLGADDYLTKPFDFGELEAR 111
Cdd:cd19925   82 AANDVETVREALRLGVVDYLIKPFTFERLRQR 113
psREC-like_D2_PleD cd17539
REC-like adaptor domain (D2) of response regulator PleD; PleD contains a REC domain (D1) with ...
 59-118 3.25e-05

REC-like adaptor domain (D2) of response regulator PleD; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a pseudo receiver (psREC)-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes the REC-like adaptor domain D2 of PleD, which is an inactive domain.


Pssm-ID: 381094 [Multi-domain]  Cd Length: 124  Bit Score: 41.92  E-value: 3.25e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 658757157  59 GEQILKKLRA--RSSNTPVLILTARAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRR 118
Cdd:cd17539   56 GLRLCSQLRSleRTRQLPILAVADPGDRGRLIRALEIGVNDYLVRPIDPNELLARVRTQIRR 117
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 69-103 3.40e-05

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 41.34  E-value: 3.40e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 658757157  69 RSSNTPVLILTARAQVEHRIELLDLGADDYLTKPF 103
Cdd:cd19920   69 ATRHIPVIFLTALTDTEDKVKGFELGAVDYITKPF 103
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 59-104 3.49e-05

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 41.81  E-value: 3.49e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 658757157  59 GEQILKKLRARSSNTPVLILTARAQVEHRIELLDLGADDYLTKPFD 104
Cdd:cd17537   59 GLELQDELLARGSNIPIIFITGHGDVPMAVEAMKAGAVDFLEKPFR 104
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 59-102 4.91e-05

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 41.42  E-value: 4.91e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 658757157  59 GEQILKKLRARSSNTPVLILTARAQVEHRIELLDLGADDYLTKP 102
Cdd:cd17555   59 GLEVLKQITKESPDTPVIVVSGAGVMSDAVEALRLGAWDYLTKP 102
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 3-108 6.88e-05

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 41.07  E-value: 6.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   3 ILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLL--KRHEYDLILLDLNLPNLNGEQILKKLRArSSNTPVLILTA 80
Cdd:cd17584    1 VLVVDDDPTCLAILKRMLLRCGYQVTTCTDAEEALSMLreNKDEFDLVITDVHMPDMDGFEFLELIRL-EMDLPVIMMSA 79

                         90       100
                 ....*....|....*....|....*...
gi 658757157  81 RAQVEHRIELLDLGADDYLTKPFDFGEL 108
Cdd:cd17584   80 DGSTSTVMKGLAHGACDYLLKPVSIEDL 107
PRK15347 PRK15347
two component system sensor kinase;
1-180 7.72e-05

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 43.09  E-value: 7.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   1 MRILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSN----TPVL 76
Cdd:PRK15347 691 LQILLVDDVETNRDIIGMMLVELGQQVTTAASGTEALELGRQHRFDLVLMDIRMPGLDGLETTQLWRDDPNNldpdCMIV 770

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157  77 ILTARAQVEHRIELLDLGADDYLTKPFDFGELeARCRALLRRNQgLGKDIisygNLDFDRKSCTVTIAKELIDLKQREFR 156
Cdd:PRK15347 771 ALTANAAPEEIHRCKKAGMNHYLTKPVTLAQL-ARALELAAEYQ-LLRGI----ELSPQDSSCSPLLDTDDMALNSKLYQ 844

                        170       180
                 ....*....|....*....|....*.
gi 658757157 157 LLEIFLtHQGK--VLNKDELLDHLYS 180
Cdd:PRK15347 845 SLLLLL-AQIEqaVENQEVLSQLLHT 869
spore_0_A TIGR02875
sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a ...
 59-126 1.48e-04

sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a transcription factor critical for the initiation of sporulation. It contains a response regulator receiver domain (pfam00072). In Bacillus subtilis, it works together with response regulator Spo0F and the phosphotransferase Spo0B, both of which are missing from at least some sporulating species and thus not part of the endospore forming bacteria minimal gene set. Spo0A, however, is universal among endospore-forming species. [Cellular processes, Sporulation and germination]


Pssm-ID: 131922 [Multi-domain]  Cd Length: 262  Bit Score: 41.70  E-value: 1.48e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   59 GEQILKKLR--ARSSNTPVLILTARAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLrrnQGLGKDI 126
Cdd:TIGR02875  63 GIGVLEKLNeiELSARPRVIMLSAFGQEKITQRAVALGADYYVLKPFDLEILAARIRQLA---WGTNADI 129
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 72-118 1.58e-04

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 42.14  E-value: 1.58e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 658757157  72 NTPVLILTARAQVEHRIELLDLGADDYLTKPFDfgelEARCRALLRR 118
Cdd:PRK11107 741 NTPIIAVTAHAMAGERERLLSAGMDDYLAKPID----EAMLKQVLLR 783
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 3-117 2.77e-04

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 39.42  E-value: 2.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   3 ILAVEDDEVLGEAIcQRFTKMGQGIDLV---TSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILT 79
Cdd:cd17535    1 VLIVDDHPLVREGL-RRLLESEPDIEVVgeaADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVLT 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 658757157  80 ARAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLR 117
Cdd:cd17535   80 AHDDPEYVLRALKAGAAGYLLKDSSPEELIEAIRAVAA 117
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 55-120 3.13e-04

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 40.08  E-value: 3.13e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 658757157  55 PNLNGEQILKKLRARSSNTPVLILTARAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRRNQ 120
Cdd:COG4566   54 PGMSGLELQEELAARGSPLPVIFLTGHGDVPMAVRAMKAGAVDFLEKPFDDQALLDAVRRALARDR 119
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
 65-116 6.39e-04

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 38.46  E-value: 6.39e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 658757157  65 KLRARSSNTPVLILTARAQVEHRIELLDLGADDYLTKPFDFGELEARCRALL 116
Cdd:cd17598   65 KSDPDLKDIPVILLTTLSDPRDVIRGLECGADNFITKPYDEKYLLSRIKYIL 116
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 2-110 6.59e-04

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 38.30  E-value: 6.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   2 RILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILTAR 81
Cdd:cd17553    2 KILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVTKERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAY 81

                         90       100
                 ....*....|....*....|....*....
gi 658757157  82 AQVEHRIELLDLGADDYLTKPFDFGELEA 110
Cdd:cd17553   82 GELDMIQESKELGALTHFAKPFDIDEIRD 110
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 2-108 8.30e-04

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 38.05  E-value: 8.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   2 RILAVEDDEVLGEAIcqRFTKMGQGIDLVTSGDVANSLLKRHE--YDLILLDLNLPNLNGEQILKKLRARSS--NTPVLI 77
Cdd:cd17562    2 KILAVDDSASIRQMV--SFTLRGAGYEVVEAADGRDALSKAQSkkFDLIITDQNMPNMDGIELIKELRKLPAykFTPILM 79

                         90       100       110
                 ....*....|....*....|....*....|.
gi 658757157  78 LTARAQVEHRIELLDLGADDYLTKPFDFGEL 108
Cdd:cd17562   80 LTTESSDEKKQEGKAAGATGWLVKPFDPEQL 110
pleD PRK09581
response regulator PleD; Reviewed
 68-120 8.44e-04

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 39.88  E-value: 8.44e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 658757157  68 ARSSNTPVLILTARAQVEHRIELLDLGADDYLTKPFDFGELEARCRALLRRNQ 120
Cdd:PRK09581 224 ERTRYVPILLLVDEDDDPRLVKALELGVNDYLMRPIDKNELLARVRTQIRRKR 276
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 59-104 8.96e-04

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 38.03  E-value: 8.96e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 658757157  59 GEQILKKLRARSSNTPVLILTARAQVEHRIELLDLGADDYLTKPFD 104
Cdd:cd17542   60 GIEALKEIKKIDPNAKVIMCSAMGQEEMVKEAIKAGAKDFIVKPFQ 105
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 59-107 9.15e-04

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 39.85  E-value: 9.15e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 658757157  59 GEQILKKLRARSSNTPVLILTARAQVEHRIELLDLGADDYLTKPFDFGE 107
Cdd:PRK10923  62 GLALLKQIKQRHPMLPVIIMTAHSDLDAAVSAYQQGAFDYLPKPFDIDE 110
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-120 1.09e-03

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 39.03  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   1 MRILAVEDDEVLGEAICQRFTKMGqGIDLV---TSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLI 77
Cdd:COG3279    2 MKILIVDDEPLARERLERLLEKYP-DLEVVgeaSNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIF 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 658757157  78 LTARAqvEHRIELLDLGADDYLTKPFDFGELEA---RCRALLRRNQ 120
Cdd:COG3279   81 TTAYD--EYALEAFEVNAVDYLLKPIDEERLAKaleKAKERLEAKA 124
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 3-110 1.30e-03

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 37.44  E-value: 1.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   3 ILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARS--SNTPVLILTA 80
Cdd:cd17580    1 ILVVDDNEDAAEMLALLLELEGAEVTTAHSGEEALEAAQRFRPDVILSDIGMPGMDGYELARRLRELPwlANTPAIALTG 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 658757157  81 RAQVEHRIELLDLGADDYLTKPFDFGELEA 110
Cdd:cd17580   81 YGQPEDRERALEAGFDAHLVKPVDPDELIE 110
PRK10610 PRK10610
chemotaxis protein CheY;
59-111 1.38e-03

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 37.65  E-value: 1.38e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 658757157  59 GEQILKKLRARS--SNTPVLILTARAQVEHRIELLDLGADDYLTKPFDFGELEAR 111
Cdd:PRK10610  65 GLELLKTIRADGamSALPVLMVTAEAKKENIIAAAQAGASGYVVKPFTAATLEEK 119
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 59-110 1.84e-03

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 36.75  E-value: 1.84e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 658757157  59 GEQILKKLRARSSNTPVLILTARAQVEHRIELLDLGADDYLTKPFDFGELEA 110
Cdd:cd17593   60 GYEVLEALPVEQLETKVIVVSGDVQPEAKERVLELGALAFLKKPFDPEKLAQ 111
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
 3-102 2.50e-03

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 36.36  E-value: 2.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   3 ILAVEDDEVLGEAIcqRFTKMGQGIDLVTSGDV--ANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILTA 80
Cdd:cd19926    1 VLVVDDEPDIRELL--EITLGRMGLDVRSARNVkeARELLASEPYDLCLTDMRLPDGSGLELVQHIQQRLPQTPVAVITA 78

                         90       100
                 ....*....|....*....|..
gi 658757157  81 RAQVEHRIELLDLGADDYLTKP 102
Cdd:cd19926   79 YGSLDTAIEALKAGAFDFLTKP 100
PRK15115 PRK15115
response regulator GlrR; Provisional
 2-108 2.82e-03

response regulator GlrR; Provisional


Pssm-ID: 185070 [Multi-domain]  Cd Length: 444  Bit Score: 38.28  E-value: 2.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   2 RILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILTAR 81
Cdd:PRK15115   7 HLLLVDDDPGLLKLLGMRLTSEGYSVVTAESGQEALRVLNREKVDLVISDLRMDEMDGMQLFAEIQKVQPGMPVIILTAH 86

                         90       100
                 ....*....|....*....|....*..
gi 658757157  82 AQVEHRIELLDLGADDYLTKPFDFGEL 108
Cdd:PRK15115  87 GSIPDAVAATQQGVFSFLTKPVDRDAL 113
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 3-118 3.98e-03

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 36.31  E-value: 3.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   3 ILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSNTPVLILTARA 82
Cdd:cd17549    1 VLLVDDDADVREALQQTLELAGFRVRAFADAEEALAALSPDFPGVVISDIRMPGMDGLELLAQIRELDPDLPVILITGHG 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 658757157  83 QVEHRIELLDLGADDYLTKPFDFGEL-EARCRALLRR 118
Cdd:cd17549   81 DVPMAVEAMRAGAYDFLEKPFDPERLlDVVRRALEKR 117
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 59-103 4.33e-03

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 35.94  E-value: 4.33e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 658757157  59 GEQILKKLRARSSNTPVLILTARAQVEHRIELLDLGADDYLTKPF 103
Cdd:cd17550   57 GLELLKEIKEKYPDLPVIMISGHGTIETAVKATKLGAYDFIEKPL 101
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 2-115 5.15e-03

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 35.85  E-value: 5.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   2 RILAVEDDEVLGEAICQRFTKMGQGIDL--VTSGDVANSLLKRH-EYDLILLD------LNLPNLNGEQILKKLRARSS- 71
Cdd:cd17557    1 TILLVEDNPGDAELIQEAFKEAGVPNELhvVRDGEEALDFLRGEgEYADAPRPdlilldLNMPRMDGFEVLREIKADPDl 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 658757157  72 -NTPVLILTARAQVEHRIELLDLGADDYLTKPFDFGELEARCRAL 115
Cdd:cd17557   81 rRIPVVVLTTSDAEEDIERAYELGANSYIVKPVDFEEFVEAIRSL 125
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-104 6.53e-03

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 36.47  E-value: 6.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   1 MRILAVEDDEVLGEAICQRFTKMG-QGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARSSnTPVLILT 79
Cdd:COG3707    4 LRVLVVDDEPLRRADLREGLREAGyEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERP-APVILLT 82

                         90       100
                 ....*....|....*....|....*
gi 658757157  80 ARAQVEHRIELLDLGADDYLTKPFD 104
Cdd:COG3707   83 AYSDPELIERALEAGVSAYLVKPLD 107
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
63-119 7.91e-03

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 36.67  E-value: 7.91e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157  63 LKKLRARSsNTPVLI---LTAR-AQVEhrIELLDLGADDYLTKPFD---------FGELEARCRALLRRN 119
Cdd:PRK00742  68 LEKIMRLR-PTPVVMvssLTERgAEIT--LRALELGAVDFVTKPFLgislgmdeyKEELAEKVRAAARAR 134
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
 3-102 8.31e-03

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 34.73  E-value: 8.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658757157   3 ILAVEDDEVLGEAICQRFTKMGQGIDLVTSGDVANSLLKRHEYDLILLDLNLPNLNGEQILKKLRARsSNTPVLILTARA 82
Cdd:cd19936    1 IALVDDDRNILTSVSMALEAEGFSVETYTDGASALDGLNARPPDLAILDIKMPRMDGMELLQRLRQK-STLPVIFLTSKD 79

                         90       100
                 ....*....|....*....|
gi 658757157  83 QVEHRIELLDLGADDYLTKP 102
Cdd:cd19936   80 DEIDEVFGLRMGADDYITKP 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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