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Conserved domains on  [gi|664004630|ref|WP_030558617|]
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DDE-type integrase/transposase/recombinase, partial [Kitasatospora aureofaciens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
transpos_IS3 super family cl41295
IS3 family transposase;
1-67 1.25e-20

IS3 family transposase;


The actual alignment was detected with superfamily member NF033516:

Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 82.61  E-value: 1.25e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 664004630   1 RDPAADLAPDLVQRDFTAVAPNRLWVADISLIPTGEGPWWLATIRDAFSRRIVGWHTSERADADLVL 67
Cdd:NF033516 195 SGHVHPVAPNLLNRQFTATRPNQVWVTDITYIRTAEGWLYLAVVLDLFSREIVGWSVSTSMSAELVL 261
 
Name Accession Description Interval E-value
transpos_IS3 NF033516
IS3 family transposase;
1-67 1.25e-20

IS3 family transposase;


Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 82.61  E-value: 1.25e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 664004630   1 RDPAADLAPDLVQRDFTAVAPNRLWVADISLIPTGEGPWWLATIRDAFSRRIVGWHTSERADADLVL 67
Cdd:NF033516 195 SGHVHPVAPNLLNRQFTATRPNQVWVTDITYIRTAEGWLYLAVVLDLFSREIVGWSVSTSMSAELVL 261
Tra5 COG2801
Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];
1-67 3.37e-18

Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442053 [Multi-domain]  Cd Length: 309  Bit Score: 75.19  E-value: 3.37e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 664004630   1 RDPAADLAPDLVqrdFTAVAPNRLWVADISLIPTGEGPWWLATIRDAFSRRIVGWHTSERADADLVL 67
Cdd:COG2801  131 SGHGGPIAPNLL---FTATAPNQVWVTDITYIPTAEGWLYLAAVIDLFSREIVGWSVSDSMDAELVV 194
PHA02517 PHA02517
putative transposase OrfB; Reviewed
 8-67 1.11e-16

putative transposase OrfB; Reviewed


Pssm-ID: 222853 [Multi-domain]  Cd Length: 277  Bit Score: 71.05  E-value: 1.11e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 664004630   8 APDLVQRDFTAVAPNRLWVADISLIPTGEGPWWLATIRDAFSRRIVGWHTSERADADLVL 67
Cdd:PHA02517  96 APDRVNRQFVATRPNQLWVADFTYVSTWQGWVYVAFIIDVFARRIVGWRVSSSMDTDFVL 155
rve pfam00665
Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into ...
 21-67 1.12e-08

Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.


Pssm-ID: 459897 [Multi-domain]  Cd Length: 98  Bit Score: 46.92  E-value: 1.12e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 664004630  21 PNRLWVADISLI--PTGEGPWWLATIRDAFSRRIVGWHTSERADADLVL 67
Cdd:pfam00665  1 PNQLWQGDFTYIriPGGGGKLYLLVIVDDFSREILAWALSSEMDAELVL 49
 
Name Accession Description Interval E-value
transpos_IS3 NF033516
IS3 family transposase;
1-67 1.25e-20

IS3 family transposase;


Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 82.61  E-value: 1.25e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 664004630   1 RDPAADLAPDLVQRDFTAVAPNRLWVADISLIPTGEGPWWLATIRDAFSRRIVGWHTSERADADLVL 67
Cdd:NF033516 195 SGHVHPVAPNLLNRQFTATRPNQVWVTDITYIRTAEGWLYLAVVLDLFSREIVGWSVSTSMSAELVL 261
Tra5 COG2801
Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];
1-67 3.37e-18

Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442053 [Multi-domain]  Cd Length: 309  Bit Score: 75.19  E-value: 3.37e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 664004630   1 RDPAADLAPDLVqrdFTAVAPNRLWVADISLIPTGEGPWWLATIRDAFSRRIVGWHTSERADADLVL 67
Cdd:COG2801  131 SGHGGPIAPNLL---FTATAPNQVWVTDITYIPTAEGWLYLAAVIDLFSREIVGWSVSDSMDAELVV 194
PHA02517 PHA02517
putative transposase OrfB; Reviewed
 8-67 1.11e-16

putative transposase OrfB; Reviewed


Pssm-ID: 222853 [Multi-domain]  Cd Length: 277  Bit Score: 71.05  E-value: 1.11e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 664004630   8 APDLVQRDFTAVAPNRLWVADISLIPTGEGPWWLATIRDAFSRRIVGWHTSERADADLVL 67
Cdd:PHA02517  96 APDRVNRQFVATRPNQLWVADFTYVSTWQGWVYVAFIIDVFARRIVGWRVSSSMDTDFVL 155
rve pfam00665
Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into ...
 21-67 1.12e-08

Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.


Pssm-ID: 459897 [Multi-domain]  Cd Length: 98  Bit Score: 46.92  E-value: 1.12e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 664004630  21 PNRLWVADISLI--PTGEGPWWLATIRDAFSRRIVGWHTSERADADLVL 67
Cdd:pfam00665  1 PNQLWQGDFTYIriPGGGGKLYLLVIVDDFSREILAWALSSEMDAELVL 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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