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Conserved domains on  [gi|664278526|ref|WP_030808695|]
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MULTISPECIES: FAD-dependent oxidoreductase [Streptomyces]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02852 super family cl30539
ferredoxin-NADP+ reductase
 108-548 1.70e-118

ferredoxin-NADP+ reductase


The actual alignment was detected with superfamily member PLN02852:

Pssm-ID: 357415  Cd Length: 491  Bit Score: 359.01  E-value: 1.70e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 108 SLPSDFGPLRVAVVGTGPAGMYAAQDLL-LHTAAEVTLIDRLPVAGGLVRYGVAPDHPATKKVGDTFSRFHSHPRVRMHL 186
Cdd:PLN02852  19 SSSSTSEPLHVCVVGSGPAGFYTADKLLkAHDGARVDIIERLPTPFGLVRSGVAPDHPETKNVTNQFSRVATDDRVSFFG 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 187 GIEVGRDVTAEELSAHHDAVIYAVGASTDRRLGVPGEETPGCLSATAFVAWYNAHPEAVAQGVDL-SAERVVVVGNGNVA 265
Cdd:PLN02852  99 NVTLGRDVSLSELRDLYHVVVLAYGAESDRRLGIPGEDLPGVLSAREFVWWYNGHPDCVHLPPDLkSSDTAVVLGQGNVA 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 266 LDVARILVADPEALAATDIAAHALDALRASRVREVVVLGRRGPGDAAYTRSELLALKHVPGVELVVDDHDPRTAAAIDAA 345
Cdd:PLN02852 179 LDCARILLRPTDELASTDIAEHALEALRGSSVRKVYLVGRRGPVQAACTAKELRELLGLKNVRVRIKEADLTLSPEDEEE 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 346 GAGDR--AGVLKGLARVRT-DAASPTGGERRIVLRFHSEVVEIRGEGDGVNSVR-------------VTDGGGDGDGGGT 409
Cdd:PLN02852 259 LKASRpkRRVYELLSKAAAaGKCAPSGGQRELHFVFFRNPTRFLDSGDGNGHVAgvklertvlegaaGSGKQVAVGTGEF 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 410 ADLKAGLLLRAIGYRGIPVPGLPFDELSGTVPHEGGRVAG-------VPGSYVVGWIKRGPSGGIGANRTCAAETVGTLL 482
Cdd:PLN02852 339 EDLPCGLVLKSIGYKSLPVDGLPFDHKRGVVPNVHGRVLSsasgadtEPGLYVVGWLKRGPTGIIGTNLTCAEETVASIA 418

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 483 ADAVAGELAAPTGDAKA----FRRLARQRNRRVVDARGLAAIDRAERDRGRRDGRPRVKLATVEELVATA 548
Cdd:PLN02852 419 EDLEQGRLRGVASPPKPgrdgLLELLESRGVRVVPFSGWEKIDSAEKEAGRARGKPREKITSIEEMLKAA 488
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 1-71 2.31e-17

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


:

Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 76.29  E-value: 2.31e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 664278526   1 MTYAITQTCCNDATCVAVCPVNCIHPTPEerafgSTEMLHIDPRACIDCGACADACPVDAIFPVDSLSAGQ 71
Cdd:COG1146    2 MPVIDTDKCIGCGACVEVCPVDVLELDEE-----GKKALVINPEECIGCGACELVCPVGAITVEDDEPEEQ 67
 
Name Accession Description Interval E-value
PLN02852 PLN02852
ferredoxin-NADP+ reductase
 108-548 1.70e-118

ferredoxin-NADP+ reductase


Pssm-ID: 215457  Cd Length: 491  Bit Score: 359.01  E-value: 1.70e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 108 SLPSDFGPLRVAVVGTGPAGMYAAQDLL-LHTAAEVTLIDRLPVAGGLVRYGVAPDHPATKKVGDTFSRFHSHPRVRMHL 186
Cdd:PLN02852  19 SSSSTSEPLHVCVVGSGPAGFYTADKLLkAHDGARVDIIERLPTPFGLVRSGVAPDHPETKNVTNQFSRVATDDRVSFFG 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 187 GIEVGRDVTAEELSAHHDAVIYAVGASTDRRLGVPGEETPGCLSATAFVAWYNAHPEAVAQGVDL-SAERVVVVGNGNVA 265
Cdd:PLN02852  99 NVTLGRDVSLSELRDLYHVVVLAYGAESDRRLGIPGEDLPGVLSAREFVWWYNGHPDCVHLPPDLkSSDTAVVLGQGNVA 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 266 LDVARILVADPEALAATDIAAHALDALRASRVREVVVLGRRGPGDAAYTRSELLALKHVPGVELVVDDHDPRTAAAIDAA 345
Cdd:PLN02852 179 LDCARILLRPTDELASTDIAEHALEALRGSSVRKVYLVGRRGPVQAACTAKELRELLGLKNVRVRIKEADLTLSPEDEEE 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 346 GAGDR--AGVLKGLARVRT-DAASPTGGERRIVLRFHSEVVEIRGEGDGVNSVR-------------VTDGGGDGDGGGT 409
Cdd:PLN02852 259 LKASRpkRRVYELLSKAAAaGKCAPSGGQRELHFVFFRNPTRFLDSGDGNGHVAgvklertvlegaaGSGKQVAVGTGEF 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 410 ADLKAGLLLRAIGYRGIPVPGLPFDELSGTVPHEGGRVAG-------VPGSYVVGWIKRGPSGGIGANRTCAAETVGTLL 482
Cdd:PLN02852 339 EDLPCGLVLKSIGYKSLPVDGLPFDHKRGVVPNVHGRVLSsasgadtEPGLYVVGWLKRGPTGIIGTNLTCAEETVASIA 418

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 483 ADAVAGELAAPTGDAKA----FRRLARQRNRRVVDARGLAAIDRAERDRGRRDGRPRVKLATVEELVATA 548
Cdd:PLN02852 419 EDLEQGRLRGVASPPKPgrdgLLELLESRGVRVVPFSGWEKIDSAEKEAGRARGKPREKITSIEEMLKAA 488
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
 117-476 2.42e-30

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 123.32  E-value: 2.42e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 117 RVAVVGTGPAGMYAAQDLLL--HtaaEVTLIDRLPVAGGLVRYGVaPDHPATKKVGDTFSRFHSHPRVRMHLGIEVGRDV 194
Cdd:COG0493  123 KVAVVGSGPAGLAAAYQLARagH---EVTVFEALDKPGGLLRYGI-PEFRLPKDVLDREIELIEALGVEFRTNVEVGKDI 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 195 TAEELSAHHDAVIYAVGASTDRRLGVPGEETPGCLSATAFVAWYNahpeavaqgvdlsaERVVVVGNGNVALDVARI--- 271
Cdd:COG0493  199 TLDELLEEFDAVFLATGAGKPRDLGIPGEDLKGVHSAMDFLTAVN--------------LGEAPDTILAVGKRVVVIggg 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 272 LVadpealaatdiaahALDALRASR---VREVVVLGRRGPGDAAYTRSEL-LALK--------HVPgVELVVDDHdprta 339
Cdd:COG0493  265 NT--------------AMDCARTALrlgAESVTIVYRRTREEMPASKEEVeEALEegveflflVAP-VEIIGDEN----- 324

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 340 aaidaagagdraGVLKGLARVRTDAASPTGGERRivlrfhsEVVEIRGEgdgvnsvrvtdgggdgdgggTADLKAGLLLR 419
Cdd:COG0493  325 ------------GRVTGLECVRMELGEPDESGRR-------RPVPIEGS--------------------EFTLPADLVIL 365

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 664278526 420 AIGYRGIP-----VPGLPFDELSGTVPHEGGRVAGVPGSYVVGWIKRGPS---GGIGANRTCAAE 476
Cdd:COG0493  366 AIGQTPDPsgleeELGLELDKRGTIVVDEETYQTSLPGVFAGGDAVRGPSlvvWAIAEGRKAARA 430
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 1-71 2.31e-17

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 76.29  E-value: 2.31e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 664278526   1 MTYAITQTCCNDATCVAVCPVNCIHPTPEerafgSTEMLHIDPRACIDCGACADACPVDAIFPVDSLSAGQ 71
Cdd:COG1146    2 MPVIDTDKCIGCGACVEVCPVDVLELDEE-----GKKALVINPEECIGCGACELVCPVGAITVEDDEPEEQ 67
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 3-62 3.00e-12

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 63.95  E-value: 3.00e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 664278526   3 YAITQTC--CNDATCVAVCPVNCIHPTPEerafGSTemlHIDPRACIDCGACADACPVDAIF 62
Cdd:cd04410   44 AFLPVSCmhCEDPPCVKACPTGAIYKDED----GIV---LIDEDKCIGCGSCVEACPYGAIV 98
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 10-60 3.08e-10

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 55.61  E-value: 3.08e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 664278526   10 CNDatCVAVCPVNCIHPTPEERAFGSTEMlHIDPRACIDCGACADACPVDA 60
Cdd:pfam12838   4 CGA--CVAACPVGAITLDEVGEKKGTKTV-VIDPERCVGCGACVAVCPTGA 51
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
15-61 6.19e-09

NADH-quinone oxidoreductase subunit NuoI;


Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 55.27  E-value: 6.19e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 664278526  15 CVAVCPVNCIHPTPEERAFGSTEMLH--IDPRACIDCGACADACPVDAI 61
Cdd:PRK05888  66 CAAICPADAITIEAAEREDGRRRTTRydINFGRCIFCGFCEEACPTDAI 114
napF TIGR00402
ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of ...
 8-67 2.83e-04

ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of the periplasmic nitrate reductase system, as in Escherichia coli. NapF interacts with the catalytic subunit, NapA, and may be an accessory protein for NapA maturation. [Energy metabolism, Electron transport]


Pssm-ID: 273060 [Multi-domain]  Cd Length: 101  Bit Score: 40.31  E-value: 2.83e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526    8 TCCNDatCVAVCPVNCIhptpeERAFGSTEMLHIDPRACIDCGACADACPVDAIFPVDSL 67
Cdd:TIGR00402  37 TRCGE--CASACENNIL-----QLGQQGQPTVEFDNAECDFCGKCAEACPTNAFHPRFPG 89
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 117-228 2.87e-03

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 39.99  E-value: 2.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526  117 RVAVVGTGPAGMYAAQDLLLHtAAEVTLIDrlpVAGGLVRYGVAPDH--PATKKVGDTFSRFHS------------HPRV 182
Cdd:pfam07992   2 DVVVIGGGPAGLAAALTLAQL-GGKVTLIE---DEGTCPYGGCVLSKalLGAAEAPEIASLWADlykrkeevvkklNNGI 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 664278526  183 RMHLGIEV------------GRDVTAEELSAHHDAVIYAVGASTdRRLGVPGEETPGC 228
Cdd:pfam07992  78 EVLLGTEVvsidpgakkvvlEELVDGDGETITYDRLVIATGARP-RLPPIPGVELNVG 134
 
Name Accession Description Interval E-value
PLN02852 PLN02852
ferredoxin-NADP+ reductase
 108-548 1.70e-118

ferredoxin-NADP+ reductase


Pssm-ID: 215457  Cd Length: 491  Bit Score: 359.01  E-value: 1.70e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 108 SLPSDFGPLRVAVVGTGPAGMYAAQDLL-LHTAAEVTLIDRLPVAGGLVRYGVAPDHPATKKVGDTFSRFHSHPRVRMHL 186
Cdd:PLN02852  19 SSSSTSEPLHVCVVGSGPAGFYTADKLLkAHDGARVDIIERLPTPFGLVRSGVAPDHPETKNVTNQFSRVATDDRVSFFG 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 187 GIEVGRDVTAEELSAHHDAVIYAVGASTDRRLGVPGEETPGCLSATAFVAWYNAHPEAVAQGVDL-SAERVVVVGNGNVA 265
Cdd:PLN02852  99 NVTLGRDVSLSELRDLYHVVVLAYGAESDRRLGIPGEDLPGVLSAREFVWWYNGHPDCVHLPPDLkSSDTAVVLGQGNVA 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 266 LDVARILVADPEALAATDIAAHALDALRASRVREVVVLGRRGPGDAAYTRSELLALKHVPGVELVVDDHDPRTAAAIDAA 345
Cdd:PLN02852 179 LDCARILLRPTDELASTDIAEHALEALRGSSVRKVYLVGRRGPVQAACTAKELRELLGLKNVRVRIKEADLTLSPEDEEE 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 346 GAGDR--AGVLKGLARVRT-DAASPTGGERRIVLRFHSEVVEIRGEGDGVNSVR-------------VTDGGGDGDGGGT 409
Cdd:PLN02852 259 LKASRpkRRVYELLSKAAAaGKCAPSGGQRELHFVFFRNPTRFLDSGDGNGHVAgvklertvlegaaGSGKQVAVGTGEF 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 410 ADLKAGLLLRAIGYRGIPVPGLPFDELSGTVPHEGGRVAG-------VPGSYVVGWIKRGPSGGIGANRTCAAETVGTLL 482
Cdd:PLN02852 339 EDLPCGLVLKSIGYKSLPVDGLPFDHKRGVVPNVHGRVLSsasgadtEPGLYVVGWLKRGPTGIIGTNLTCAEETVASIA 418

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 483 ADAVAGELAAPTGDAKA----FRRLARQRNRRVVDARGLAAIDRAERDRGRRDGRPRVKLATVEELVATA 548
Cdd:PLN02852 419 EDLEQGRLRGVASPPKPgrdgLLELLESRGVRVVPFSGWEKIDSAEKEAGRARGKPREKITSIEEMLKAA 488
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
 117-476 2.42e-30

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 123.32  E-value: 2.42e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 117 RVAVVGTGPAGMYAAQDLLL--HtaaEVTLIDRLPVAGGLVRYGVaPDHPATKKVGDTFSRFHSHPRVRMHLGIEVGRDV 194
Cdd:COG0493  123 KVAVVGSGPAGLAAAYQLARagH---EVTVFEALDKPGGLLRYGI-PEFRLPKDVLDREIELIEALGVEFRTNVEVGKDI 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 195 TAEELSAHHDAVIYAVGASTDRRLGVPGEETPGCLSATAFVAWYNahpeavaqgvdlsaERVVVVGNGNVALDVARI--- 271
Cdd:COG0493  199 TLDELLEEFDAVFLATGAGKPRDLGIPGEDLKGVHSAMDFLTAVN--------------LGEAPDTILAVGKRVVVIggg 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 272 LVadpealaatdiaahALDALRASR---VREVVVLGRRGPGDAAYTRSEL-LALK--------HVPgVELVVDDHdprta 339
Cdd:COG0493  265 NT--------------AMDCARTALrlgAESVTIVYRRTREEMPASKEEVeEALEegveflflVAP-VEIIGDEN----- 324

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 340 aaidaagagdraGVLKGLARVRTDAASPTGGERRivlrfhsEVVEIRGEgdgvnsvrvtdgggdgdgggTADLKAGLLLR 419
Cdd:COG0493  325 ------------GRVTGLECVRMELGEPDESGRR-------RPVPIEGS--------------------EFTLPADLVIL 365

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 664278526 420 AIGYRGIP-----VPGLPFDELSGTVPHEGGRVAGVPGSYVVGWIKRGPS---GGIGANRTCAAE 476
Cdd:COG0493  366 AIGQTPDPsgleeELGLELDKRGTIVVDEETYQTSLPGVFAGGDAVRGPSlvvWAIAEGRKAARA 430
PTZ00188 PTZ00188
adrenodoxin reductase; Provisional
 115-332 1.45e-27

adrenodoxin reductase; Provisional


Pssm-ID: 240308  Cd Length: 506  Bit Score: 116.14  E-value: 1.45e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 115 PLRVAVVGTGPAGMYAAQDLLLHTAAEVTLIDRLPVAGGLVRYGVAPDHPATKKVGDTFSRFHSHPRVRMHLGIEVGRDV 194
Cdd:PTZ00188  39 PFKVGIIGAGPSALYCCKHLLKHERVKVDIFEKLPNPYGLIRYGVAPDHIHVKNTYKTFDPVFLSPNYRFFGNVHVGVDL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 195 TAEELSAHHDAVIYAVGAS--------TDRRLGVPGEET-----PGCLSATAFVAWY-NAHPEAVAQGVDL---SAERVV 257
Cdd:PTZ00188 119 KMEELRNHYNCVIFCCGASevsipigqQDEDKAVSGGETnprkqNGIFHARDLIYFYnNMYNDVRCKAVDNylnSFENFT 198

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 664278526 258 VVG---NGNVALDVARILVADPEALAATDIAAHALDALRASRVREVVVLGRRGPGDAAYTRSELLALKHVPGVELVVD 332
Cdd:PTZ00188 199 TSIiigNGNVSLDIARILIKSPDDLSKTDISSDYLKVIKRHNIKHIYIVGRRGFWQSSFTNAELRELISLENTKVILS 276
gltD PRK12810
glutamate synthase subunit beta; Reviewed
 117-239 3.90e-23

glutamate synthase subunit beta; Reviewed


Pssm-ID: 237213 [Multi-domain]  Cd Length: 471  Bit Score: 102.55  E-value: 3.90e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 117 RVAVVGTGPAGMYAAQDLLL--HtaaEVTLIDRLPVAGGLVRYGVaPDHPATKKVGDTfsrfhshpRVRM--------HL 186
Cdd:PRK12810 145 KVAVVGSGPAGLAAADQLARagH---KVTVFERADRIGGLLRYGI-PDFKLEKEVIDR--------RIELmeaegiefRT 212

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 664278526 187 GIEVGRDVTAEELSAHHDAVIYAVGASTDRRLGVPGEETPGCLSATAFVAWYN 239
Cdd:PRK12810 213 NVEVGKDITAEELLAEYDAVFLGTGAYKPRDLGIPGRDLDGVHFAMDFLIQNT 265
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 117-234 2.54e-20

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 94.56  E-value: 2.54e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 117 RVAVVGTGPAGMYAAQDLLL--HtaaEVTLIDRLPVAGGLVRYGVaPDHPATKKVGDT-FSRFHSHPrVRMHLGIEVGRD 193
Cdd:PRK12771 139 RVAVIGGGPAGLSAAYHLRRmgH---AVTIFEAGPKLGGMMRYGI-PAYRLPREVLDAeIQRILDLG-VEVRLGVRVGED 213

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 664278526 194 VTAEELSAHHDAVIYAVGASTDRRLGVPGEETPGCLSATAF 234
Cdd:PRK12771 214 ITLEQLEGEFDAVFVAIGAQLGKRLPIPGEDAAGVLDAVDF 254
PRK11749 PRK11749
dihydropyrimidine dehydrogenase subunit A; Provisional
 101-236 4.85e-20

dihydropyrimidine dehydrogenase subunit A; Provisional


Pssm-ID: 236967 [Multi-domain]  Cd Length: 457  Bit Score: 92.93  E-value: 4.85e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 101 GEPVFERSLPSDfgpLRVAVVGTGPAGMYAAQDLLLHtAAEVTLIDRLPVAGGLVRYGVapdhPATKKVGDTFSRFHSHP 180
Cdd:PRK11749 129 GWVLFKRAPKTG---KKVAVIGAGPAGLTAAHRLARK-GYDVTIFEARDKAGGLLRYGI----PEFRLPKDIVDREVERL 200

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 664278526 181 R---VRMHLGIEVGRDVTAEELSAHHDAVIYAVGASTDRRLGVPGEETPGCLSATAFVA 236
Cdd:PRK11749 201 LklgVEIRTNTEVGRDITLDELRAGYDAVFIGTGAGLPRFLGIPGENLGGVYSAVDFLT 259
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 1-71 2.31e-17

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 76.29  E-value: 2.31e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 664278526   1 MTYAITQTCCNDATCVAVCPVNCIHPTPEerafgSTEMLHIDPRACIDCGACADACPVDAIFPVDSLSAGQ 71
Cdd:COG1146    2 MPVIDTDKCIGCGACVEVCPVDVLELDEE-----GKKALVINPEECIGCGACELVCPVGAITVEDDEPEEQ 67
PRK12814 PRK12814
putative NADPH-dependent glutamate synthase small subunit; Provisional
 49-236 2.41e-16

putative NADPH-dependent glutamate synthase small subunit; Provisional


Pssm-ID: 139246 [Multi-domain]  Cd Length: 652  Bit Score: 82.47  E-value: 2.41e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526  49 CGA-CADACP---VDAifPVdSLSAGQREYADINAAYYEGAEPPAAEVDGPnfhawgepvferslpsdfgplRVAVVGTG 124
Cdd:PRK12814 147 CPApCEEACRrhgVDE--PV-SICALKRYAADRDMESAERYIPERAPKSGK---------------------KVAIIGAG 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 125 PAGMYAAQDLLLhTAAEVTLIDRLPVAGGLVRYG--------------VAPdhpaTKKVGDTFsRFhshprvrmhlGIEV 190
Cdd:PRK12814 203 PAGLTAAYYLLR-KGHDVTIFDANEQAGGMMRYGiprfrlpesvidadIAP----LRAMGAEF-RF----------NTVF 266

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 664278526 191 GRDVTAEELSAHHDAVIYAVGASTDRRLGVPGEETPGCLSATAFVA 236
Cdd:PRK12814 267 GRDITLEELQKEFDAVLLAVGAQKASKMGIPGEELPGVISGIDFLR 312
PRK12809 PRK12809
putative oxidoreductase Fe-S binding subunit; Reviewed
 117-254 2.95e-16

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183762 [Multi-domain]  Cd Length: 639  Bit Score: 82.00  E-value: 2.95e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 117 RVAVVGTGPAGMYAAqDLLLHTAAEVTLIDRLPVAGGLVRYGVAP---DHPATKKVGDTFSRFHSHprvrMHLGIEVGRD 193
Cdd:PRK12809 312 KVAVIGAGPAGLGCA-DILARAGVQVDVFDRHPEIGGMLTFGIPPfklDKTVLSQRREIFTAMGID----FHLNCEIGRD 386

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 664278526 194 VTAEELSAHHDAVIYAVGASTDRRLGVPGEETPGCLSATAFVAwynAHPEAVaQGVDLSAE 254
Cdd:PRK12809 387 ITFSDLTSEYDAVFIGVGTYGMMRADLPHEDAPGVIQALPFLT---AHTRQL-MGLPESEE 443
PRK13984 PRK13984
putative oxidoreductase; Provisional
 28-231 6.92e-15

putative oxidoreductase; Provisional


Pssm-ID: 172486 [Multi-domain]  Cd Length: 604  Bit Score: 77.50  E-value: 6.92e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526  28 PEER---------AFGSTEMLHIDPRaCIDCGACADACP--------VDAIFPvDSLSAGQREYADIN------------ 78
Cdd:PRK13984 161 PEERvksfieivkGYSKEQAMQEAAR-CVECGICTDTCPahmdipqyIKAIYK-DDLEEGLRWLYKTNplsmvcgrvcth 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526  79 ------AAYYEGaEPPAAE------VDGPNFHAWGEPVFERSLPSDfgpLRVAVVGTGPAGMYAAQDLLLhTAAEVTLID 146
Cdd:PRK13984 239 kcetvcSIGHRG-EPIAIRwlkryiVDNVPVEKYSEILDDEPEKKN---KKVAIVGSGPAGLSAAYFLAT-MGYEVTVYE 313

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 147 RLPVAGGLVRYGVA----PDHPATKKVGdtfsrFHSHPRVRMHLGIEVGRDVTAEELSAHHDAVIYAVGASTDRRLGVPG 222
Cdd:PRK13984 314 SLSKPGGVMRYGIPsyrlPDEALDKDIA-----FIEALGVKIHLNTRVGKDIPLEELREKHDAVFLSTGFTLGRSTRIPG 388


                 ....*....
gi 664278526 223 EETPGCLSA 231
Cdd:PRK13984 389 TDHPDVIQA 397
PRK12770 PRK12770
putative glutamate synthase subunit beta; Provisional
 115-241 1.72e-14

putative glutamate synthase subunit beta; Provisional


Pssm-ID: 237197 [Multi-domain]  Cd Length: 352  Bit Score: 75.03  E-value: 1.72e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 115 PLRVAVVGTGPAGMYAAQDLLLHtAAEVTLIDRLPVAGGLVRYGVAPDH-P------ATKKVGDTFSRFHSHPRV----- 182
Cdd:PRK12770  18 GKKVAIIGAGPAGLAAAGYLACL-GYEVHVYDKLPEPGGLMLFGIPEFRiPiervreGVKELEEAGVVFHTRTKVccgep 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 664278526 183 -RMHLGIE-VGRDVTAEELSAHHDAVIYAVGASTDRRLGVPGEETPGCLSATAFVAWYNAH 241
Cdd:PRK12770  97 lHEEEGDEfVERIVSLEELVKKYDAVLIATGTWKSRKLGIPGEDLPGVYSALEYLFRIRAA 157
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 9-62 4.25e-14

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 67.08  E-value: 4.25e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 664278526   9 CCNDATCVAVCPVNCIHPTPEERAFgsteMLHIDPRACIDCGACADACPVDAIF 62
Cdd:COG1143    4 CIGCGLCVRVCPVDAITIEDGEPGK----VYVIDPDKCIGCGLCVEVCPTGAIS 53
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 1-69 6.32e-14

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 66.99  E-value: 6.32e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526   1 MTYAI-TQTCCNDATCVAVCPVNCIHPtpeerafgSTEMLHIDPRACIDCGACADACPVDAIFPVDSLSA 69
Cdd:COG4231   15 MRYVIdEDKCTGCGACVKVCPADAIEE--------GDGKAVIDPDLCIGCGSCVQVCPVDAIKLEKRVPE 76
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 3-62 3.00e-12

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 63.95  E-value: 3.00e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 664278526   3 YAITQTC--CNDATCVAVCPVNCIHPTPEerafGSTemlHIDPRACIDCGACADACPVDAIF 62
Cdd:cd04410   44 AFLPVSCmhCEDPPCVKACPTGAIYKDED----GIV---LIDEDKCIGCGSCVEACPYGAIV 98
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
1-61 7.14e-12

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 60.90  E-value: 7.14e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 664278526   1 MTYAITQTCCNDATCVAVCPVNCIHPTpeerafgsTEMLHIDPRACIDCGACADACPVDAI 61
Cdd:COG2768    5 KPYVDEEKCIGCGACVKVCPVGAISIE--------DGKAVIDPEKCIGCGACIEVCPVGAI 57
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 117-234 1.06e-11

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 67.46  E-value: 1.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 117 RVAVVGTGPAGMyAAQDLLLHTAAEVTLIDRLPVAGGLVRYGVapdhPATKKVGDTFSR---FHSHPRVRMHLGIEVGRD 193
Cdd:PRK12769 329 RVAIIGAGPAGL-ACADVLARNGVAVTVYDRHPEIGGLLTFGI----PAFKLDKSLLARrreIFSAMGIEFELNCEVGKD 403

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 664278526 194 VTAEELSAHHDAVIYAVGASTDRRLGVPGEETPGCLSATAF 234
Cdd:PRK12769 404 ISLESLLEDYDAVFVGVGTYRSMKAGLPNEDAPGVYDALPF 444
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 10-65 5.69e-11

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 58.91  E-value: 5.69e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 664278526  10 CNdaTCVAVCPVNCIHPTPEErafgsteMLHIDPRACIDCGACADACPVDAIFPVD 65
Cdd:COG1144   35 CG--LCWIVCPDGAIRVDDGK-------YYGIDYDYCKGCGICAEVCPVKAIEMVP 81
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 15-69 9.67e-11

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 59.33  E-value: 9.67e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 664278526  15 CVAVCPVNCIHPTPEERAFGSTEM-LHIDPRACIDCGACADACPVDAIFPVDSLSA 69
Cdd:cd10549   48 CVEVCPTGAIELTPEGKEYVPKEKeAEIDEEKCIGCGLCVKVCPVDAITLEDELEI 103
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 14-61 1.94e-10

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 58.56  E-value: 1.94e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 664278526  14 TCVAVCPVNCIHPTPEErafGSTEMLHIDPRACIDCGACADACPVDAI 61
Cdd:cd10549   13 ICVKACPTDAIELGPNG---AIARGPEIDEDKCVFCGACVEVCPTGAI 57
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 10-60 3.08e-10

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 55.61  E-value: 3.08e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 664278526   10 CNDatCVAVCPVNCIHPTPEERAFGSTEMlHIDPRACIDCGACADACPVDA 60
Cdd:pfam12838   4 CGA--CVAACPVGAITLDEVGEKKGTKTV-VIDPERCVGCGACVAVCPTGA 51
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 8-62 5.21e-10

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 57.41  E-value: 5.21e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 664278526   8 TCCNDATCVAVCPVNCIHPTPEERAfgstemlHIDPRACIDCGACADACPVDAIF 62
Cdd:cd10549   79 KCIGCGLCVKVCPVDAITLEDELEI-------VIDKEKCIGCGICAEVCPVNAIK 126
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 15-61 6.34e-10

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 55.44  E-value: 6.34e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 664278526  15 CVAVCPVNCIHPTPEErafgstemLHIDPRACIDCGACADACPVDAI 61
Cdd:COG2221   23 CVAVCPTGAISLDDGK--------LVIDEEKCIGCGACIRVCPTGAI 61
NapF COG1145
Ferredoxin [Energy production and conversion];
6-61 1.82e-09

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 58.58  E-value: 1.82e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 664278526   6 TQTCCNDATCVAVCPVNCIHPTPEERafgsteMLHIDPRACIDCGACADACPVDAI 61
Cdd:COG1145  181 AEKCIGCGLCVKVCPTGAIRLKDGKP------QIVVDPDKCIGCGACVKVCPVGAI 230
PRK12775 PRK12775
putative trifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta/ferritin ...
 117-239 1.92e-09

putative trifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta/ferritin domain-containing protein; Provisional


Pssm-ID: 183738 [Multi-domain]  Cd Length: 1006  Bit Score: 60.73  E-value: 1.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526  117 RVAVVGTGPAGMYAAQDLLLHtAAEVTLIDRLPVAGGLVRYGVaPDHPATKKVGDTFSRFHSHPRVRMHLGIEVGRDVTA 196
Cdd:PRK12775  432 KVAICGSGPAGLAAAADLVKY-GVDVTVYEALHVVGGVLQYGI-PSFRLPRDIIDREVQRLVDIGVKIETNKVIGKTFTV 509

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 664278526  197 EEL--SAHHDAVIYAVGASTDRRLGVPGEETPGCLSATAFVAWYN 239
Cdd:PRK12775  510 PQLmnDKGFDAVFLGVGAGAPTFLGIPGEFAGQVYSANEFLTRVN 554
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 14-61 3.79e-09

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 53.19  E-value: 3.79e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 664278526  14 TCVAVCPVNCIhptpeerAFGSTEMLHIDPRACIDCGACADACPVDAI 61
Cdd:COG1149   18 LCVEVCPEGAI-------KLDDGGAPVVDPDLCTGCGACVGVCPTGAI 58
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 8-62 4.99e-09

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 54.51  E-value: 4.99e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 664278526   8 TC--CNDATCVAVCPVNCIHPTPEerafgsTEMLHIDPRACIDCGACADACPVDAIF 62
Cdd:cd10550   48 VCrqCEDAPCVEACPVGAISRDEE------TGAVVVDEDKCIGCGMCVEACPFGAIR 98
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
15-61 6.19e-09

NADH-quinone oxidoreductase subunit NuoI;


Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 55.27  E-value: 6.19e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 664278526  15 CVAVCPVNCIHPTPEERAFGSTEMLH--IDPRACIDCGACADACPVDAI 61
Cdd:PRK05888  66 CAAICPADAITIEAAEREDGRRRTTRydINFGRCIFCGFCEEACPTDAI 114
PRK12778 PRK12778
bifunctional dihydroorotate dehydrogenase B NAD binding subunit/NADPH-dependent glutamate ...
 117-239 9.20e-09

bifunctional dihydroorotate dehydrogenase B NAD binding subunit/NADPH-dependent glutamate synthase;


Pssm-ID: 237200 [Multi-domain]  Cd Length: 752  Bit Score: 58.21  E-value: 9.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 117 RVAVVGTGPAGMYAAQDlLLHTAAEVTLIDRLPVAGGLVRYGVaPDHPATKKVGDTFSRFHSHPRVRMHLGIEVGRDVTA 196
Cdd:PRK12778 433 KVAVIGSGPAGLSFAGD-LAKRGYDVTVFEALHEIGGVLKYGI-PEFRLPKKIVDVEIENLKKLGVKFETDVIVGKTITI 510

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 664278526 197 EELSAHH-DAVIYAVGASTDRRLGVPGEETPGCLSATAFVAWYN 239
Cdd:PRK12778 511 EELEEEGfKGIFIASGAGLPNFMNIPGENSNGVMSSNEYLTRVN 554
Fer4_9 pfam13187
4Fe-4S dicluster domain;
9-61 1.04e-08

4Fe-4S dicluster domain;


Pssm-ID: 463801 [Multi-domain]  Cd Length: 50  Bit Score: 51.40  E-value: 1.04e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 664278526    9 CCNDATCVAVCPVNCIhptpEERAFGSTEMLHIDPRACIDCGACADACPVDAI 61
Cdd:pfam13187   2 CTGCGACVAACPAGAI----VPDLVGQTIRGDIAGLACIGCGACVDACPRGAI 50
DMSOR_beta_like cd16371
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 3-61 1.14e-08

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319893 [Multi-domain]  Cd Length: 140  Bit Score: 53.72  E-value: 1.14e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 664278526   3 YAITQTC--CNDATCVAVCPVNCIHptpeERAFGSTEmlhIDPRACIDCGACADACPVDAI 61
Cdd:cd16371   48 YFLSMSCnhCENPACVKVCPTGAIT----KREDGIVV---VDQDKCIGCGYCVWACPYGAP 101
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
10-71 2.04e-08

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 53.12  E-value: 2.04e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 664278526  10 CNDATCVAVCPVNCIHPTpeerafgsTEMLHIDPRACIDCGACADACPVDAIFPVDSLSAGQ 71
Cdd:COG1142   55 CEDAPCAEVCPVGAITRD--------DGAVVVDEEKCIGCGLCVLACPFGAITMVGEKSRAV 108
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 10-62 2.93e-08

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 53.80  E-value: 2.93e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 664278526  10 CNDATCVAVCPVNCIHPtpeeRAFGSTemlHIDPRACIDCGACADACPVDAIF 62
Cdd:COG0437   63 CDDPPCVKVCPTGATYK----REDGIV---LVDYDKCIGCRYCVAACPYGAPR 108
FDH_b_like cd10562
uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes ...
 10-61 3.26e-08

uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319884 [Multi-domain]  Cd Length: 161  Bit Score: 53.08  E-value: 3.26e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 664278526  10 CNDATCVAVCPVNCIHPTpeerAFGSTemlHIDPRACIDCGACADACPVDAI 61
Cdd:cd10562   73 CTDAACVKVCPTGALYKT----ENGAV---VVDEDKCIGCGYCVAACPFDVP 117
PRK12831 PRK12831
putative oxidoreductase; Provisional
 117-270 8.73e-08

putative oxidoreductase; Provisional


Pssm-ID: 183780 [Multi-domain]  Cd Length: 464  Bit Score: 54.64  E-value: 8.73e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 117 RVAVVGTGPAGMYAAQDLLlHTAAEVTLIDRLPVAGGLVRYG-----------VAPDHPATKKVGdtfsrfhshprVRMH 185
Cdd:PRK12831 142 KVAVIGSGPAGLTCAGDLA-KMGYDVTIFEALHEPGGVLVYGipefrlpketvVKKEIENIKKLG-----------VKIE 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 186 LGIEVGRDVTAEEL--SAHHDAVIYAVGASTDRRLGVPGEETPGCLSATAFV-------AWYNAHPEAVAQGvdlsaERV 256
Cdd:PRK12831 210 TNVVVGKTVTIDELleEEGFDAVFIGSGAGLPKFMGIPGENLNGVFSANEFLtrvnlmkAYKPEYDTPIKVG-----KKV 284

                        170
                 ....*....|....
gi 664278526 257 VVVGNGNVALDVAR 270
Cdd:PRK12831 285 AVVGGGNVAMDAAR 298
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 1-57 8.75e-08

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 48.79  E-value: 8.75e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 664278526    1 MTYAITQTCCNDATCVAVCPVNCIHPTPEERAFGsTEMLHIDPRACIDCGACADACP 57
Cdd:pfam13237   1 KVVIDPDKCIGCGRCTAACPAGLTRVGAIVERLE-GEAVRIGVWKCIGCGACVEACP 56
FDH_beta_like cd16366
beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family ...
 10-61 1.65e-07

beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family contains beta FeS subunits of several dehydrogenases in the DMSO reductase superfamily, including formate dehydrogenase N (FDH-N), tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N is a major component of nitrate respiration of Escherichia coli; it catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate to a cytochrome. W-FDH contains a tungsten instead of molybdenum at the catalytic center and seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate.


Pssm-ID: 319888 [Multi-domain]  Cd Length: 156  Bit Score: 50.86  E-value: 1.65e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 664278526  10 CNDATCVAVCPVNCIHPTPeerafgsTEMLHIDPRACIDCGACADACPVDAI 61
Cdd:cd16366   73 CTDAGCLAACPTGAIIRTE-------TGTVVVDPETCIGCGYCVNACPFDIP 117
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 14-61 1.66e-07

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 52.69  E-value: 1.66e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 664278526  14 TCVAVCPVNCIHptpeerafGSTEMLH-IDPRACIDCGACADACPVDAI 61
Cdd:COG2878  144 DCIKACPFDAIV--------GAAKGMHtVDEDKCTGCGLCVEACPVDCI 184
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 10-61 1.75e-07

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 50.72  E-value: 1.75e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 664278526  10 CNDATCVAVCPVNCIhptpeERAFGStemLHIDPRACIDCGACADACPVDAI 61
Cdd:cd10554   59 CEDAPCANVCPVGAI-----SQEDGV---VQVDEERCIGCKLCVLACPFGAI 102
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
102-212 3.69e-07

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 52.94  E-value: 3.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526 102 EPVFERSLPSDFgplRVAVVGTGPAGMYAAQDLllhtAA---EVTLIDRLPVAGGLVR--YGVAPD-HPATKKVGDTFSR 175
Cdd:COG1148  130 EPLEPIKVPVNK---RALVIGGGIAGMTAALEL----AEqgyEVYLVEKEPELGGRAAqlHKTFPGlDCPQCILEPLIAE 202

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 664278526 176 FHSHPRVRMHLGIEV-------GR-DVT-----AEELSAHHDAVIYAVGA 212
Cdd:COG1148  203 VEANPNITVYTGAEVeevsgyvGNfTVTikkgpREEIEIEVGAIVLATGF 252
DMSOR_beta_like cd16367
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 5-61 5.77e-07

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319889 [Multi-domain]  Cd Length: 138  Bit Score: 48.84  E-value: 5.77e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 664278526   5 ITQTC--CNDATCVAVCPVNCIHptpeeraFGSTEMLHIDPrACIDCGACADACPVDAI 61
Cdd:cd16367   53 VPTACrhCVDPVCMIGCPTGAIH-------RDDGGEVVISD-ACCGCGNCASACPYGAI 103
Fer4_17 pfam13534
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 9-59 7.07e-07

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 433287 [Multi-domain]  Cd Length: 61  Bit Score: 46.30  E-value: 7.07e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 664278526    9 CCNDATCVAVCPVNCIHPTP-----EERAFGSTEMLHIDPRA--CIDCGACADACPVD 59
Cdd:pfam13534   2 CIQCGCCVDECPRYLLNGDEpkklmRAAYLGDLEELQANKVAnlCSECGLCEYACPMG 59
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
 10-62 7.26e-07

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 49.84  E-value: 7.26e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 664278526  10 CNDATCVAVCPVNCIHPTPEerafGSTEmlhIDPRACIDCGACADACPVDAIF 62
Cdd:cd10551   56 CENPPCVKVCPTGATYKRED----GIVL---VDYDKCIGCRYCMAACPYGARY 101
DMSOR_beta_like cd16374
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 10-61 7.51e-07

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319896 [Multi-domain]  Cd Length: 139  Bit Score: 48.81  E-value: 7.51e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 664278526  10 CNDATCVAVCPVNCIHPTPEERAFgstemlhIDPRACIDCGACADACPVDAI 61
Cdd:cd16374   46 CEDAPCMEVCPTGAIYRDEDGAVL-------VDPDKCIGCGMCAMACPFGVP 90
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
9-67 1.08e-06

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 51.18  E-value: 1.08e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 664278526   9 CCNDATCVAVCPVNCIHPTpEERAfgstemlHIDPRACIDCGACADACPVDAIFPVDSL 67
Cdd:COG4624   93 CKNCYPCVRACPVKAIKVD-DGKA-------EIDEEKCISCGQCVAVCPFGAITEKSDI 143
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 15-65 1.15e-06

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 48.41  E-value: 1.15e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 664278526  15 CVAVCPVNCIHPTPEERAFGSTEMLHIDPR--ACI-DCGACADACPVDAIFPVD 65
Cdd:cd16373   22 CVEACPTGVIQPAGLEDGLEGGRTPYLDPRegPCDlCCDACVEVCPTGALRPLD 75
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
10-61 1.43e-06

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 50.06  E-value: 1.43e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 664278526  10 CNDatCVAVCPVNCIHPTPEerafgstemlhIDPRACIDCGACADACPVDAI 61
Cdd:COG0348  215 CGL--CVKVCPMGIDIRKGE-----------INQSECINCGRCIDACPKDAI 253
Fer4 pfam00037
4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to ...
 41-61 1.73e-06

4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 459642 [Multi-domain]  Cd Length: 24  Bit Score: 44.55  E-value: 1.73e-06
                          10        20
                  ....*....|....*....|.
gi 664278526   41 IDPRACIDCGACADACPVDAI 61
Cdd:pfam00037   3 IDEEKCIGCGACVEVCPVGAI 23
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
35-65 1.85e-06

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 45.88  E-value: 1.85e-06
                         10        20        30
                 ....*....|....*....|....*....|.
gi 664278526  35 STEMLHIDPRACIDCGACADACPVDAIFPVD 65
Cdd:COG2768    2 SLGKPYVDEEKCIGCGACVKVCPVGAISIED 32
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 10-62 5.99e-06

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 45.73  E-value: 5.99e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 664278526  10 CNDATCVAVCPVNCIhptpEERAFGStemLHIDPRACIDCGACADACPVDAIF 62
Cdd:cd16370   56 CEDPPCAEACPTGAL----EPRKGGG---VVLDKEKCIGCGNCVKACIVGAIF 101
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
7-65 8.61e-06

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 48.48  E-value: 8.61e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 664278526   7 QTCCNDATCVAVCPVNCIHPTPEERAFGSTemlHIDPRACIDCGACADACPVDAIFPVD 65
Cdd:COG4624   57 CCCCCCRCCVAISCIQVRGIIIIDKRGPSI---IRDKEKCKNCYPCVRACPVKAIKVDD 112
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 38-65 1.33e-05

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 43.18  E-value: 1.33e-05
                         10        20
                 ....*....|....*....|....*...
gi 664278526  38 MLHIDPRACIDCGACADACPVDAIFPVD 65
Cdd:COG1149    5 IPVIDEEKCIGCGLCVEVCPEGAIKLDD 32
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 41-65 1.35e-05

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 43.12  E-value: 1.35e-05
                         10        20
                 ....*....|....*....|....*
gi 664278526  41 IDPRACIDCGACADACPVDAIFPVD 65
Cdd:COG2221   12 IDEEKCIGCGLCVAVCPTGAISLDD 36
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 15-65 1.92e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 44.25  E-value: 1.92e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 664278526  15 CVAVCPVNCIHPTPEerafgstemlHIDPRACIDCGACADACPVDAIFPVD 65
Cdd:cd16372   85 CVGFCPEGAMFKHED----------YPEPFKCIACGICVKACPTGALELVE 125
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 41-61 2.61e-05

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 43.92  E-value: 2.61e-05
                         10        20
                 ....*....|....*....|.
gi 664278526  41 IDPRACIDCGACADACPVDAI 61
Cdd:cd10549    3 YDPEKCIGCGICVKACPTDAI 23
PRK09898 PRK09898
ferredoxin-like protein;
6-61 2.62e-05

ferredoxin-like protein;


Pssm-ID: 182135 [Multi-domain]  Cd Length: 208  Bit Score: 45.60  E-value: 2.62e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 664278526   6 TQTC--CNDATCVAVCPVNCIHPTPEERAFGSTE----------------MLHIDPRA-----CIDCGACADACPVDAI 61
Cdd:PRK09898 120 ADTCrqCKEPQCMNVCPIGAITWQQKEGCITVDHkrcigcsacttacpwmMATVNTESkksskCVLCGECANACPTGAL 198
PRK13795 PRK13795
hypothetical protein; Provisional
 15-58 4.85e-05

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 46.14  E-value: 4.85e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 664278526  15 CVAVCPVNCIhptpeeRAFGSTEMLHIDPRACIDCGACADACPV 58
Cdd:PRK13795 589 CVGACPTGAI------RIEEGKRKISVDEEKCIHCGKCTEVCPV 626
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 9-61 6.46e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 43.40  E-value: 6.46e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 664278526   9 CCNdaTCVAVCPVNCIHPTPEE-------RAFgstemlhIDPRACI------DCGACADACPVDAI 61
Cdd:cd16373   58 CCD--ACVEVCPTGALRPLDLEeqkvkmgVAV-------IDKDRCLawqggtDCGVCVEACPTEAI 114
Fer4_16 pfam13484
4Fe-4S double cluster binding domain;
46-61 1.18e-04

4Fe-4S double cluster binding domain;


Pssm-ID: 463893 [Multi-domain]  Cd Length: 65  Bit Score: 40.17  E-value: 1.18e-04
                          10
                  ....*....|....*.
gi 664278526   46 CIDCGACADACPVDAI 61
Cdd:pfam13484   1 CGSCGKCIDACPTGAI 16
Fer4_6 pfam12837
4Fe-4S binding domain; This superfamily includes proteins containing domains which bind to ...
 40-61 1.22e-04

4Fe-4S binding domain; This superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 432822 [Multi-domain]  Cd Length: 24  Bit Score: 39.14  E-value: 1.22e-04
                          10        20
                  ....*....|....*....|..
gi 664278526   40 HIDPRACIDCGACADACPVDAI 61
Cdd:pfam12837   3 EVDPDKCIGCGRCVVVCPYGAI 24
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 46-81 1.23e-04

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 39.82  E-value: 1.23e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 664278526   46 CIDCGACADACPVDAIFPVDSLSAGQREYADINAAY 81
Cdd:pfam12838   1 CIGCGACVAACPVGAITLDEVGEKKGTKTVVIDPER 36
DMSOR_beta_like cd16369
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 10-57 1.46e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319891 [Multi-domain]  Cd Length: 172  Bit Score: 42.76  E-value: 1.46e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 664278526  10 CNDATCVAVCPVNCIHPTPEerafgSTEMLHIDPRaCIDCGACADACP 57
Cdd:cd16369   54 CEDPTCAEVCPADAIKVTED-----GVVQSALKPR-CIGCSNCVNACP 95
HybA_like cd10561
the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 ...
 10-57 1.89e-04

the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 (Hyd-2), an enzyme that catalyzes the reversible oxidation of H2 to protons and electrons. Hyd-2 is membrane-associated and forms an unusual heterotetrameric [NiFe]-hydrogenase in that it lacks the typical cytochrome b membrane anchor subunit that transfers electrons to the quinone pool. The electron transfer subunit of Hyd-2 (HybA) which is predicted to contain four iron-sulfur clusters, is essential for electron transfer from Hyd-2 to menaquinone/demethylmenaquinone (MQ/DMQ) to couple hydrogen oxidation to fumarate reduction.


Pssm-ID: 319883 [Multi-domain]  Cd Length: 196  Bit Score: 42.58  E-value: 1.89e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 664278526  10 CNDATCVAVCPVNCIHPTPEerafGStemLHIDPRACIDCGACADACP 57
Cdd:cd10561   72 CLDPACVSACPVGALRKTPE----GP---VTYDEDKCIGCRYCMVACP 112
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
14-61 2.07e-04

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 44.08  E-value: 2.07e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 664278526  14 TCVAVCPVNCIHPTPEERAfgstemlHIDPRACIDCGACADACPVDAI 61
Cdd:COG1148  503 RCVEVCPYGAISIDEKGVA-------EVNPALCKGCGTCAAACPSGAI 543
PRK10882 PRK10882
hydrogenase 2 operon protein HybA;
5-57 2.73e-04

hydrogenase 2 operon protein HybA;


Pssm-ID: 236786 [Multi-domain]  Cd Length: 328  Bit Score: 43.12  E-value: 2.73e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 664278526   5 ITQTC--CNDATCVAVCPVNCIHPTPEerafgsTEMLHIDPRACIDCGACADACP 57
Cdd:PRK10882 108 IKKQCmhCVDPNCVSVCPVSALTKDPK------TGIVHYDKDVCTGCRYCMVACP 156
napF TIGR00402
ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of ...
 8-67 2.83e-04

ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of the periplasmic nitrate reductase system, as in Escherichia coli. NapF interacts with the catalytic subunit, NapA, and may be an accessory protein for NapA maturation. [Energy metabolism, Electron transport]


Pssm-ID: 273060 [Multi-domain]  Cd Length: 101  Bit Score: 40.31  E-value: 2.83e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526    8 TCCNDatCVAVCPVNCIhptpeERAFGSTEMLHIDPRACIDCGACADACPVDAIFPVDSL 67
Cdd:TIGR00402  37 TRCGE--CASACENNIL-----QLGQQGQPTVEFDNAECDFCGKCAEACPTNAFHPRFPG 89
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 46-65 3.77e-04

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 38.96  E-value: 3.77e-04
                         10        20
                 ....*....|....*....|
gi 664278526  46 CIDCGACADACPVDAIFPVD 65
Cdd:COG1143    4 CIGCGLCVRVCPVDAITIED 23
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 4-61 5.69e-04

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 40.30  E-value: 5.69e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 664278526   4 AITQTC-------CNdaTCVAVCPVNCIHPTPEErafGSTEMLHIDPRACIDCGACADACPVDAI 61
Cdd:cd10564   75 EIGDSClalqgveCR--SCQDACPTQAIRFRPRL---GGIALPELDADACTGCGACVSVCPVGAI 134
Fer4_2 pfam12797
4Fe-4S binding domain; This superfamily includes proteins containing domains which bind to ...
 37-58 6.03e-04

4Fe-4S binding domain; This superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 463711 [Multi-domain]  Cd Length: 22  Bit Score: 37.38  E-value: 6.03e-04
                          10        20
                  ....*....|....*....|..
gi 664278526   37 EMLHIDPRACIDCGACADACPV 58
Cdd:pfam12797   1 WKPLIDADKCIGCGACVSACPA 22
FixX COG2440
Ferredoxin-like protein FixX [Energy production and conversion];
10-61 6.08e-04

Ferredoxin-like protein FixX [Energy production and conversion];


Pssm-ID: 441981 [Multi-domain]  Cd Length: 87  Bit Score: 39.03  E-value: 6.08e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 664278526  10 CNDATCVAVCPVNCIHPTPEERafgstemLHIDPRACIDCGACADACPVDAI 61
Cdd:COG2440   27 CLAKPCTRYCPAGVYEIVGDGR-------LQINYENCLECGTCRIKCPTQNI 71
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 41-81 6.16e-04

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 38.88  E-value: 6.16e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 664278526  41 IDPRACIDCGACADACPVDAIFPVDslsagqREYADINAAY 81
Cdd:COG1144   27 VDEDKCIGCGLCWIVCPDGAIRVDD------GKYYGIDYDY 61
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 4-61 6.82e-04

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 39.92  E-value: 6.82e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 664278526   4 AITQTC--CNDatCVAVCPVNCIHP----TPEerafgstemLHIDPRACIDCGACADACPVDAI 61
Cdd:cd10564   10 LFLDLCtrCGD--CVEACPEGIIVRgdggFPE---------LDFSRGECTFCGACAEACPEGAL 62
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
 22-59 7.63e-04

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 42.24  E-value: 7.63e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 664278526  22 NCI-HPTPEERAFGSTEMlhidprACIDCGACADACPVD 59
Cdd:PRK05035 353 NCLlAPSATELPPPPPEQ------PCIRCGACADACPAS 385
NapF COG1145
Ferredoxin [Energy production and conversion];
41-66 1.19e-03

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 40.86  E-value: 1.19e-03
                         10        20
                 ....*....|....*....|....*.
gi 664278526  41 IDPRACIDCGACADACPVDAIFPVDS 66
Cdd:COG1145  179 IDAEKCIGCGLCVKVCPTGAIRLKDG 204
PsaC COG5703
Photosystem I reaction center iron-sulfur center subunit VII, PsaC [Energy production and ...
 7-72 1.37e-03

Photosystem I reaction center iron-sulfur center subunit VII, PsaC [Energy production and conversion]; Photosystem I reaction center iron-sulfur center subunit VII, PsaC is part of the Pathway/BioSystem: Photosystem I


Pssm-ID: 444413 [Multi-domain]  Cd Length: 82  Bit Score: 37.88  E-value: 1.37e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 664278526   7 QTCCNDATCVAVCPVNCIHPTPEERAFGSTEMLHIDPRACIDCGACADACPVDAIFPVDSLSAGQR 72
Cdd:COG5703    9 DTCIGCTQCVRACPTDVLEMVPWDGCKAGQIAASPRTEDCVGCKRCETACPTDFLSIRVYLSNAET 74
RnfC COG4656
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfC subunit [Energy production and ...
 32-59 1.38e-03

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfC subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfC subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 443694 [Multi-domain]  Cd Length: 451  Bit Score: 41.28  E-value: 1.38e-03
                         10        20
                 ....*....|....*....|....*...
gi 664278526  32 AFGSTEMLHIDPRACIDCGACADACPVD 59
Cdd:COG4656  352 ALTKEEVPPPEEQPCIRCGRCVDACPMG 379
Ppro0129 COG2907
Predicted flavin-containing amine oxidase [General function prediction only];
114-153 1.85e-03

Predicted flavin-containing amine oxidase [General function prediction only];


Pssm-ID: 442151 [Multi-domain]  Cd Length: 423  Bit Score: 40.87  E-value: 1.85e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 664278526 114 GPLRVAVVGTGPAGMYAAqdLLLHTAAEVTLIDRLPVAGG 153
Cdd:COG2907    2 ARMRIAVIGSGISGLTAA--WLLSRRHDVTLFEANDRLGG 39
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 38-61 2.52e-03

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 36.46  E-value: 2.52e-03
                          10        20
                  ....*....|....*....|....
gi 664278526   38 MLHIDPRACIDCGACADACPVDAI 61
Cdd:pfam13237   1 KVVIDPDKCIGCGRCTAACPAGLT 24
rnfB TIGR01944
electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in ...
 41-61 2.56e-03

electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the B subunit. [Energy metabolism, Electron transport]


Pssm-ID: 273887 [Multi-domain]  Cd Length: 165  Bit Score: 39.01  E-value: 2.56e-03
                          10        20
                  ....*....|....*....|.
gi 664278526   41 IDPRACIDCGACADACPVDAI 61
Cdd:TIGR01944 110 IDEDNCIGCTKCIQACPVDAI 130
Fer4_18 pfam13746
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 15-56 2.71e-03

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404610 [Multi-domain]  Cd Length: 114  Bit Score: 37.76  E-value: 2.71e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 664278526   15 CVAVCPVncihptpeerafgstemlHIDPR-----ACIDCGACADAC 56
Cdd:pfam13746  67 CVQVCPT------------------GIDIRkglqlECINCGLCIDAC 95
PRK08348 PRK08348
NADH-plastoquinone oxidoreductase subunit; Provisional
 8-61 2.83e-03

NADH-plastoquinone oxidoreductase subunit; Provisional


Pssm-ID: 181399 [Multi-domain]  Cd Length: 120  Bit Score: 37.89  E-value: 2.83e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 664278526   8 TCCNDATCVAVCPVNCIHPTPEERAfgstemLHIDPRACIDCGACADACPVDAI 61
Cdd:PRK08348  43 KCVGCRMCVTVCPAGVFVYLPEIRK------VALWTGRCVFCGQCVDVCPTGAL 90
Fer4_16 pfam13484
4Fe-4S double cluster binding domain;
15-57 2.85e-03

4Fe-4S double cluster binding domain;


Pssm-ID: 463893 [Multi-domain]  Cd Length: 65  Bit Score: 36.31  E-value: 2.85e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 664278526   15 CVAVCPVNCIH---PTPEERAFGSTEM-----LHIDPRACID------CGACADACP 57
Cdd:pfam13484   7 CIDACPTGAIVgpeGVLDARRCISYLTiekkgLIPDELRCLLgnrcygCDICQDVCP 63
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 117-228 2.87e-03

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 39.99  E-value: 2.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278526  117 RVAVVGTGPAGMYAAQDLLLHtAAEVTLIDrlpVAGGLVRYGVAPDH--PATKKVGDTFSRFHS------------HPRV 182
Cdd:pfam07992   2 DVVVIGGGPAGLAAALTLAQL-GGKVTLIE---DEGTCPYGGCVLSKalLGAAEAPEIASLWADlykrkeevvkklNNGI 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 664278526  183 RMHLGIEV------------GRDVTAEELSAHHDAVIYAVGASTdRRLGVPGEETPGC 228
Cdd:pfam07992  78 EVLLGTEVvsidpgakkvvlEELVDGDGETITYDRLVIATGARP-RLPPIPGVELNVG 134
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
15-61 2.96e-03

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 39.66  E-value: 2.96e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 664278526  15 CVAVCPVNCIHptpeeRAFGSTEMLHI--DPRACIDCGACADACPVDAI 61
Cdd:COG0348  184 CRYLCPYGAFQ-----GLLSDLSTLRVryDRGDCIDCGLCVKVCPMGID 227
TH_beta_N cd10552
N-terminal FeS domain of pyrogallol-phloroglucinol transhydroxylase (TH), beta subunit; This ...
 1-62 3.66e-03

N-terminal FeS domain of pyrogallol-phloroglucinol transhydroxylase (TH), beta subunit; This family includes the beta subunit of pyrogallol-phloroglucinol transhydroxylase (TH), a cytoplasmic molybdenum (Mo) enzyme from anaerobic microorganisms like Pelobacter acidigallici and Desulfitobacterium hafniense which catalyzes the conversion of pyrogallol to phloroglucinol, an important building block of plant polymers. TH belongs to the DMSO reductase (DMSOR) family; it is a heterodimer consisting of a large alpha catalytic subunit and a small beta FeS subunit. The beta subunit has two domains with the N-terminal domain containing three [4Fe-4S] centers and a seven-stranded, mainly antiparallel beta-barrel domain. In the anaerobic bacterium Pelobacter acidigallici, gallic acid, pyrogallol, phloroglucinol, or phloroglucinol carboxylic acid are fermented to three molecules of acetate (plus CO2), and TH is the key enzyme in the fermentation pathway, which converts pyrogallol to phloroglucinol in the absence of O2.


Pssm-ID: 319874 [Multi-domain]  Cd Length: 186  Bit Score: 38.85  E-value: 3.66e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 664278526   1 MTYaITQTC--CNDATCVAVCPVNCIHptpeERAFGsteMLHIDPRACIDCGACADACPVDAIF 62
Cdd:cd10552   57 VAY-LPVPCnhCDNAPCIKAAKDGAVY----KRDDG---IVIIDPEKAKGQKQLVDACPYGAIY 112
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
120-164 4.50e-03

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 35.97  E-value: 4.50e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 664278526  120 VVGTGPAGMYAAQdLLLHTAAEVTLIDRLPVAGGLVRYGVAPDHP 164
Cdd:pfam13450   1 IVGAGLAGLVAAA-LLAKRGFRVLVLEKRDRLGGNAYSYRVPGYV 44
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 14-58 4.97e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 38.01  E-value: 4.97e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 664278526  14 TCVAVCPVNCIHPTPEERAFgsteMLHIDPRACIDCGACADACPV 58
Cdd:cd16373  104 VCVEACPTEAIAIVLEDDVL----RPVVDEDKCVGCGLCEYVCPV 144
Fer4_8 pfam13183
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 10-59 5.31e-03

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 433017 [Multi-domain]  Cd Length: 64  Bit Score: 35.75  E-value: 5.31e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 664278526   10 CND-ATCVAVCPV------NCIHPTPEERAF--GSTEMLHIDPRA---CIDCGACADACPVD 59
Cdd:pfam13183   2 CIRcGACLAACPVylvtggRFPGDPRGGAAAllGRLEALEGLAEGlwlCTLCGACTEVCPVG 63
PhsB_like cd10553
uncharacterized beta subfamily of DMSO Reductase similar to Desulfonauticus sp PhsB; This ...
 10-57 6.31e-03

uncharacterized beta subfamily of DMSO Reductase similar to Desulfonauticus sp PhsB; This family includes beta FeS subunits of anaerobic DMSO reductase (DMSOR) superfamily that have yet to be characterized. DMSOR consists of a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and the tungsten-containing formate dehydrogenase (FDH-T). Examples of heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319875 [Multi-domain]  Cd Length: 146  Bit Score: 37.34  E-value: 6.31e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 664278526  10 CNDATCVAVCPVNCIhptpEERAfgSTEMLHIDPRACIDCGACADACP 57
Cdd:cd10553   61 CENPWCVKACPTGAM----QKRE--KDGIVYVDQELCIGCKACIEACP 102
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 15-91 6.43e-03

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 38.44  E-value: 6.43e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 664278526  15 CVAVCPVNCIHPTPE-ERAFGSTEMLHIDPRACIDC-GACADACPVDAIFPVDSLSAGQREYADINAAYYEGAEPPAAE 91
Cdd:COG2878  175 CVEACPVDCIEMVPVsPTVVVSSWDKGKAVRKVVGCiGLCCKKCCPAAAITVNNLAAIIDYKKCTCCGCCEKCCPTAII 253
Rli1 COG1245
Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ...
 15-61 6.70e-03

Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440858 [Multi-domain]  Cd Length: 592  Bit Score: 39.38  E-value: 6.70e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 664278526  15 CVAVCPVN-----CIHpTPEERAFgstemLHIDPRACIDCGACADACPVDAI 61
Cdd:COG1245   21 CIKYCPVNrtgkeAIE-IDEDDGK-----PVISEELCIGCGICVKKCPFDAI 66
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 15-61 7.84e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 36.87  E-value: 7.84e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 664278526  15 CVAVCPVNCIHPTPEERAfgstemlhidPRACIDCGACADACPVDAI 61
Cdd:cd16370   91 CVKACIVGAIFWDEETNK----------PIICIHCGYCARYCPHDVL 127
oorD PRK09626
2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed
 15-65 8.32e-03

2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed


Pssm-ID: 236597 [Multi-domain]  Cd Length: 103  Bit Score: 36.24  E-value: 8.32e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 664278526  15 CVAVCPVNCIHPTPEERAFGSTEMLHIDPRACIDCGACADACPVDAIFPVD 65
Cdd:PRK09626  24 CVSVCPAGVLAMRIDPHAVLGKMIKVVHPESCIGCRECELHCPDFAIYVAD 74
PRK06273 PRK06273
ferredoxin; Provisional
 5-62 9.93e-03

ferredoxin; Provisional


Pssm-ID: 235764 [Multi-domain]  Cd Length: 165  Bit Score: 37.00  E-value: 9.93e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 664278526   5 ITQTCCNDATCVAVCPVNCIHPTPEE-----RAFGSTEMLHIDPRACIDCGACADACPVDAIF 62
Cdd:PRK06273  47 FEELCIGCGGCANVCPTKAIEMIPVEpvkitEGYVKTKIPKIDYEKCVYCLYCHDFCPVFALF 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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