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Conserved domains on  [gi|664449826|ref|WP_030971580|]
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MULTISPECIES: helix-turn-helix domain-containing protein [Streptomyces]

Protein Classification

winged helix-turn-helix transcriptional regulator( domain architecture ID 10004391)

winged helix-turn-helix (HTH) transcriptional regulator containing a HxlR family HTH domain; similar to HTH-type transcriptional regulator HxlR, a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|10679470|10908318

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
16-119 5.19e-36

DNA-binding transcriptional regulator, HxlR family [Transcription];


:

Pssm-ID: 441339  Cd Length: 108  Bit Score: 119.59  E-value: 5.19e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664449826  16 DVFSRACPSRGTLEHVTGRWGALTLGALYEGSFRFNELRRRVDGVSEKMLAQTLHALERDGLVHREAQPTNPPRVDYELT 95
Cdd:COG1733    4 DLKEADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLT 83

                         90       100
                 ....*....|....*....|....
gi 664449826  96 ALGREVAGRLIALIECLEGRMDEV 119
Cdd:COG1733   84 EKGRSLLPVLDALAEWGEEHLPEI 107
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
16-119 5.19e-36

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 119.59  E-value: 5.19e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664449826  16 DVFSRACPSRGTLEHVTGRWGALTLGALYEGSFRFNELRRRVDGVSEKMLAQTLHALERDGLVHREAQPTNPPRVDYELT 95
Cdd:COG1733    4 DLKEADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLT 83

                         90       100
                 ....*....|....*....|....
gi 664449826  96 ALGREVAGRLIALIECLEGRMDEV 119
Cdd:COG1733   84 EKGRSLLPVLDALAEWGEEHLPEI 107
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 31-108 3.68e-26

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 93.91  E-value: 3.68e-26
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 664449826   31 VTGRWGALTLGALYEGSFRFNELRRRVDGVSEKMLAQTLHALERDGLVHREAQPTNPPRVDYELTALGREVAGRLIAL 108
Cdd:pfam01638   2 IGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQEL 79
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
16-119 5.19e-36

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 119.59  E-value: 5.19e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664449826  16 DVFSRACPSRGTLEHVTGRWGALTLGALYEGSFRFNELRRRVDGVSEKMLAQTLHALERDGLVHREAQPTNPPRVDYELT 95
Cdd:COG1733    4 DLKEADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLT 83

                         90       100
                 ....*....|....*....|....
gi 664449826  96 ALGREVAGRLIALIECLEGRMDEV 119
Cdd:COG1733   84 EKGRSLLPVLDALAEWGEEHLPEI 107
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 31-108 3.68e-26

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 93.91  E-value: 3.68e-26
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 664449826   31 VTGRWGALTLGALYEGSFRFNELRRRVDGVSEKMLAQTLHALERDGLVHREAQPTNPPRVDYELTALGREVAGRLIAL 108
Cdd:pfam01638   2 IGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQEL 79
PadR COG1695
DNA-binding transcriptional regulator, PadR family [Transcription];
52-118 1.44e-04

DNA-binding transcriptional regulator, PadR family [Transcription];


Pssm-ID: 441301  Cd Length: 102  Bit Score: 38.38  E-value: 1.44e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 664449826  52 ELRRRVDG---VSEKMLAQTLHALERDGLV--HREAQPTNPPRVDYELTALGREVAGRLIALIECLEGRMDE 118
Cdd:COG1695   31 ELEERSGGfwkVSEGTLYPALKRLEKEGLVesEWEESEGGPRRKYYRLTEAGREELAEWLEEWEKLAEALEA 102
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
40-113 1.51e-03

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 37.18  E-value: 1.51e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 664449826  40 LGALYEGSFRFNELRRRVDgVSEKMLAQTLHALERDGLVHREAQptnpprvDYELTALGREVAGRLIALIECLE 113
Cdd:COG4742   22 LLLLAEGPKTRSELAESLD-VSRSTILRQLKELEERGLIERDDG-------EYELTTLGRLVVEEMEPLLDTLE 87
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
39-125 1.57e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 36.10  E-value: 1.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664449826  39 TLGALYE-GSFRFNELRRRVdGVSEKMLAQTLHALERDGLVHREAQPTNPPRVDYELTALGREVAGRLIALIECLEGRMD 117
Cdd:COG1846   43 VLAALAEaGGLTQSELAERL-GLTKSTVSRLLDRLEEKGLVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELL 121


                 ....*...
gi 664449826 118 EVLASRER 125
Cdd:COG1846  122 AGLSEEEL 129
PadR pfam03551
Transcriptional regulator PadR-like family; Members of this family are transcriptional ...
 40-101 2.97e-03

Transcriptional regulator PadR-like family; Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.


Pssm-ID: 397561  Cd Length: 74  Bit Score: 34.15  E-value: 2.97e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 664449826   40 LGALYEGSFRFNELRrrvdgvsekmLAQTLHALERDGLV--HREAQPTNPPRVDYELTALGREV 101
Cdd:pfam03551  19 LEELSGGFWRPSEGT----------LYPILKRLEKEGLVesEWVDSGGGPPRKYYRLTDAGRRE 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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