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Conserved domains on  [gi|664518790|ref|WP_031035420|]
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nitroreductase [Streptomyces sp. NRRL F-5650]

Protein Classification

nitroreductase( domain architecture ID 10114820)

nitroreductase such as Pseudomonas oleovorans nitrobenzene nitroreductase that catalyzes the two-electron reduction of nitrobenzene to produce a nitrosobenzene intermediate, which is immediately reduced to hydroxylaminobenzene by a second two-electron transfer

Gene Ontology:  GO:0016491
PubMed:  7601851

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PnbA_NfnB-like cd02136
nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as ...
 16-225 1.70e-46

nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.


:

Pssm-ID: 380313 [Multi-domain]  Cd Length: 152  Bit Score: 151.20  E-value: 1.70e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  16 LIRGRHASRAFRPEPVPEDTMRRIFSLAGAAPSNSNAQPWQVEVVSGAARRRLADAlrsahaegrtsvdfpyseemyapv 95
Cdd:cd02136    1 AIKSRRSVRAFKDKPVPKETIEKILEAARRAPSGKNTQPWRVYVVTGKARERLKKA------------------------ 56

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  96 hqsrraafgaelygalgigpddhparaaydaesldFYGAPHAAFLFVDGDGEARLAADVGAYMQTLLLAMTAYGVDSCPQ 175
Cdd:cd02136   57 -----------------------------------FFGAPVALFLTMDKVLGPWSWFDLGAFLQNLMLAAHALGLGTCPQ 101

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 664518790 176 GLLSFYADTVRTELGVTGGK-LLVGISFGYADEAAPVNRVRTERAPFEATT 225
Cdd:cd02136  102 GALAGYPDVVRKELGIPDDEeLVCGIALGYPDPDAPVNQFRTPREPLEEFV 152
PRK07877 super family cl35627
Rv1355c family protein;
28-125 5.14e-04

Rv1355c family protein;


The actual alignment was detected with superfamily member PRK07877:

Pssm-ID: 236122 [Multi-domain]  Cd Length: 722  Bit Score: 40.74  E-value: 5.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  28 PEPVPEDTMRRIFSLAGAAPSNSNAQPWQVEVVsgaarrrlADALRSAHAEGRTS-VDFPY---SEEMYAPVHQSRRAAF 103
Cdd:PRK07877 369 AEALPQDALEIVAAAAIRAPSGGNVQPWHIEAD--------QDRLTIRLAPEHTSaMDVGYrgsAVAVGAALFNARVAAA 440

                         90       100
                 ....*....|....*....|....
gi 664518790 104 GAELYGA--LGIGPDDHPARAAYD 125
Cdd:PRK07877 441 AHGLLGPveFFPGDEGSPLRATLR 464
 
Name Accession Description Interval E-value
PnbA_NfnB-like cd02136
nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as ...
 16-225 1.70e-46

nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.


Pssm-ID: 380313 [Multi-domain]  Cd Length: 152  Bit Score: 151.20  E-value: 1.70e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  16 LIRGRHASRAFRPEPVPEDTMRRIFSLAGAAPSNSNAQPWQVEVVSGAARRRLADAlrsahaegrtsvdfpyseemyapv 95
Cdd:cd02136    1 AIKSRRSVRAFKDKPVPKETIEKILEAARRAPSGKNTQPWRVYVVTGKARERLKKA------------------------ 56

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  96 hqsrraafgaelygalgigpddhparaaydaesldFYGAPHAAFLFVDGDGEARLAADVGAYMQTLLLAMTAYGVDSCPQ 175
Cdd:cd02136   57 -----------------------------------FFGAPVALFLTMDKVLGPWSWFDLGAFLQNLMLAAHALGLGTCPQ 101

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 664518790 176 GLLSFYADTVRTELGVTGGK-LLVGISFGYADEAAPVNRVRTERAPFEATT 225
Cdd:cd02136  102 GALAGYPDVVRKELGIPDDEeLVCGIALGYPDPDAPVNQFRTPREPLEEFV 152
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 13-222 6.48e-27

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 101.08  E-value: 6.48e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  13 AEKLIRGRHASRAFRPEPVPEDTMRRIFSLAGAAPSNSNAQPWQVEVVSGAA-RRRLADALRSAHAEGrtsvdfpyseem 91
Cdd:COG0778    1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPElRERLAEALAEANQEW------------ 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  92 yapvhqsrraafgaelygalgigpddhparaaydaesldFYGAPHAAFLFVD-----GDGEARLAADVGAYMQTLLLAMT 166
Cdd:COG0778   69 ---------------------------------------VADAPVLIVVCADpdrseKVPERYALLDAGIAAQNLLLAAR 109

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 664518790 167 AYGVDSCPQGllSFYADTVRTELGVTGG-KLLVGISFGYADEAAPvnrvRTERAPFE 222
Cdd:COG0778  110 ALGLGTCWIG--GFDPEKVRELLGLPEGeEPVALLALGYPAEELN----PRPRKPLE 160
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 17-204 6.71e-26

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 98.62  E-value: 6.71e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790   17 IRGRHASRAFRPEPVPEDTMRRIFSLAGAAPSNSNAQPWQ-VEVVSGAARRRLADALRSAHAEgrtsvdfpysEEMYAPV 95
Cdd:pfam00881   1 IRQRRSVRKFDPEPVPKEVLEEILEAARRAPSAGNLQPWRfYVVTDGELRYRLAEAALELLLV----------EPAAALL 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790   96 HQSRRAAFGAELYgalgigpddhpARAAYDAESLDFYGAPHAAFLFVDGDGEARLAA-DVGAYMQTLLLAMTAYGVDSCP 174
Cdd:pfam00881  71 LLLRRDANLKLLL-----------QDFLRGAPVLIVITASLSTYLRKAAERAYREALlDAGAAAQNLLLAATSLGLGSCP 139

                         170       180       190
                  ....*....|....*....|....*....|.
gi 664518790  175 QGLLSFYAdtVRTELGVTGGKLLVG-ISFGY 204
Cdd:pfam00881 140 IGGFDAAA--VRELLGLPDDERLVGlIAVGY 168
PRK13294 PRK13294
F420-0--gamma-glutamyl ligase; Provisional
 11-210 1.13e-09

F420-0--gamma-glutamyl ligase; Provisional


Pssm-ID: 183957 [Multi-domain]  Cd Length: 448  Bit Score: 57.33  E-value: 1.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  11 GSAEKLIRGRHAS-------RAFRPEPVPEDTMRRIFSLAGAAPSNSNAQPWQ-VEVVSGAARRRLADALRSAHAEGRTS 82
Cdd:PRK13294 244 GTAEALELGRREAvllrrsvREFSDDPVDPEAVRRAVAAALTAPAPHHTRPVRfVWLRSAAVRTRLLDAMRDAWRADLRA 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  83 VDFpySEEMYApvhqsRRAAFGAELYGA--------LGIGPDDHPARAAYDAESLDFYGAphaaflfvdgdgearlaadV 154
Cdd:PRK13294 324 DGL--SEESIA-----RRVRRGDILYDApelvvpflVPDGAHSYPDARRTAAERTMFTVA-------------------V 377

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 664518790 155 GAYMQTLLLAMTAYGVDSCPQGLLSFYADTVRTELGVTGGKLLVG-ISFGYADEAAP 210
Cdd:PRK13294 378 GAAVQNLLVALAVEGLGSCWIGSTIFAADVVRAVLDLPADWEPLGaVAIGHPAEPPG 434
BluB TIGR02476
5,6-dimethylbenzimidazole synthase; A previously published hypothesis that BluB, involved in ...
 15-72 1.15e-08

5,6-dimethylbenzimidazole synthase; A previously published hypothesis that BluB, involved in cobalamin biosynthesis, is EC 1.16.8.1 (cob(II)yrinic acid a,c-diamide reductase) is now contradicted by newer work ascribing a role in 5,6-dimethylbenzimidazole (DMB) biosynthesis. The BluB protein is related to the nitroreductase family (pfam0881). [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 162875  Cd Length: 205  Bit Score: 53.21  E-value: 1.15e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 664518790   15 KLIRGRHASRAFRPEPVPEDTMRRIFSLAGAAPSNSNAQPWQVEVVSGAARRRLADAL 72
Cdd:TIGR02476  11 RLIRERRDVRHFRSDPVPEAVLERLLDAAHHAPSVGFSQPWRFVRVESPATREAVHAL 68
PRK07877 PRK07877
Rv1355c family protein;
28-125 5.14e-04

Rv1355c family protein;


Pssm-ID: 236122 [Multi-domain]  Cd Length: 722  Bit Score: 40.74  E-value: 5.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  28 PEPVPEDTMRRIFSLAGAAPSNSNAQPWQVEVVsgaarrrlADALRSAHAEGRTS-VDFPY---SEEMYAPVHQSRRAAF 103
Cdd:PRK07877 369 AEALPQDALEIVAAAAIRAPSGGNVQPWHIEAD--------QDRLTIRLAPEHTSaMDVGYrgsAVAVGAALFNARVAAA 440

                         90       100
                 ....*....|....*....|....
gi 664518790 104 GAELYGA--LGIGPDDHPARAAYD 125
Cdd:PRK07877 441 AHGLLGPveFFPGDEGSPLRATLR 464
 
Name Accession Description Interval E-value
PnbA_NfnB-like cd02136
nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as ...
 16-225 1.70e-46

nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.


Pssm-ID: 380313 [Multi-domain]  Cd Length: 152  Bit Score: 151.20  E-value: 1.70e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  16 LIRGRHASRAFRPEPVPEDTMRRIFSLAGAAPSNSNAQPWQVEVVSGAARRRLADAlrsahaegrtsvdfpyseemyapv 95
Cdd:cd02136    1 AIKSRRSVRAFKDKPVPKETIEKILEAARRAPSGKNTQPWRVYVVTGKARERLKKA------------------------ 56

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  96 hqsrraafgaelygalgigpddhparaaydaesldFYGAPHAAFLFVDGDGEARLAADVGAYMQTLLLAMTAYGVDSCPQ 175
Cdd:cd02136   57 -----------------------------------FFGAPVALFLTMDKVLGPWSWFDLGAFLQNLMLAAHALGLGTCPQ 101

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 664518790 176 GLLSFYADTVRTELGVTGGK-LLVGISFGYADEAAPVNRVRTERAPFEATT 225
Cdd:cd02136  102 GALAGYPDVVRKELGIPDDEeLVCGIALGYPDPDAPVNQFRTPREPLEEFV 152
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 13-222 6.48e-27

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 101.08  E-value: 6.48e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  13 AEKLIRGRHASRAFRPEPVPEDTMRRIFSLAGAAPSNSNAQPWQVEVVSGAA-RRRLADALRSAHAEGrtsvdfpyseem 91
Cdd:COG0778    1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPElRERLAEALAEANQEW------------ 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  92 yapvhqsrraafgaelygalgigpddhparaaydaesldFYGAPHAAFLFVD-----GDGEARLAADVGAYMQTLLLAMT 166
Cdd:COG0778   69 ---------------------------------------VADAPVLIVVCADpdrseKVPERYALLDAGIAAQNLLLAAR 109

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 664518790 167 AYGVDSCPQGllSFYADTVRTELGVTGG-KLLVGISFGYADEAAPvnrvRTERAPFE 222
Cdd:COG0778  110 ALGLGTCWIG--GFDPEKVRELLGLPEGeEPVALLALGYPAEELN----PRPRKPLE 160
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 17-204 6.71e-26

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 98.62  E-value: 6.71e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790   17 IRGRHASRAFRPEPVPEDTMRRIFSLAGAAPSNSNAQPWQ-VEVVSGAARRRLADALRSAHAEgrtsvdfpysEEMYAPV 95
Cdd:pfam00881   1 IRQRRSVRKFDPEPVPKEVLEEILEAARRAPSAGNLQPWRfYVVTDGELRYRLAEAALELLLV----------EPAAALL 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790   96 HQSRRAAFGAELYgalgigpddhpARAAYDAESLDFYGAPHAAFLFVDGDGEARLAA-DVGAYMQTLLLAMTAYGVDSCP 174
Cdd:pfam00881  71 LLLRRDANLKLLL-----------QDFLRGAPVLIVITASLSTYLRKAAERAYREALlDAGAAAQNLLLAATSLGLGSCP 139

                         170       180       190
                  ....*....|....*....|....*....|.
gi 664518790  175 QGLLSFYAdtVRTELGVTGGKLLVG-ISFGY 204
Cdd:pfam00881 140 IGGFDAAA--VRELLGLPDDERLVGlIAVGY 168
Nitro_FMN_reductase cd02062
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 17-204 1.96e-20

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380311 [Multi-domain]  Cd Length: 139  Bit Score: 83.50  E-value: 1.96e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  17 IRGRHASRAFRPEPVPEDTMRRIFSLAGAAPSNSNAQPWQVEVVSGAARRRLADALRSAHAEGrtsvdfpyseemyapvh 96
Cdd:cd02062    1 IKTRRSIRKFTDKPVPEEKLRKILEAARLAPSAGNLQPWRFIVVRDREKKEKLAKLAAPNQKF----------------- 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  97 qsrraafgaelygalgigpddhparaaydaesldFYGAPHAAFLFVDGDGEARLAA-DVGAYMQTLLLAMTAYGVDSCPQ 175
Cdd:cd02062   64 ----------------------------------IAGAPVVIVVVADPDKSRPWALeDAGAAAQNLLLAAAALGLGSCWI 109

                        170       180       190
                 ....*....|....*....|....*....|
gi 664518790 176 GLLSFYADTVRTELGVTGGKLLVG-ISFGY 204
Cdd:cd02062  110 GGFDFREDKVRELLGIPENLRPVAlIAIGY 139
nitroreductase cd20610
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 17-204 1.36e-12

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380331 [Multi-domain]  Cd Length: 167  Bit Score: 63.45  E-value: 1.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  17 IRGRHASRAFRPEPVPEDTMRRIFSLAGAAPSNSNAQPWQVEVVSGAAR-RRLADALRSAHAEGRTSVDFPYSEEMyAPV 95
Cdd:cd20610    1 IKKRRSIRKFKPDPVPKEDIEKILEAANWAPSGMNRQNWEFVVVKGGEKiEKIGISIKKKNEEIARLLEKVFAEKP-IRF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  96 HQSRRAAFgaeLYGalgigpddhparaaydaesldfyGAPHAAFLFVDGDGEARLA-AD---VGAYMQTLLLAMTAYGVD 171
Cdd:cd20610   80 RKFRRFFT---LFG-----------------------GAPVLVVVYTEPYKPPEERkPDlqsVSAAIQNLLLAAHALGLG 133

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 664518790 172 SC----PqgllSFYADTVRTELGVTGGKLLVG-ISFGY 204
Cdd:cd20610  134 TCwmtgP----LYAEDEIEEILEIPDDKELVAvTPLGY 167
MhqN-like cd02137
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily ...
 14-210 9.75e-12

nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380314 [Multi-domain]  Cd Length: 147  Bit Score: 60.72  E-value: 9.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  14 EKLIRGRHASRAFRPE-PVPEDTMRRIFSLAGAAPSNSNAQPWQVEVV-SGAARRRLADAlrsahAEGRTSVDfpyseem 91
Cdd:cd02137    1 LEVIKSRRSVRNFDPDhKIPKEELKEILELATLAPSSFNLQPWRFVVVrDPELKAKLAEA-----AYNQPQVT------- 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  92 yapvhqsrraafgaelygalgigpddhparaayDAesldfygaphAAFLFVDGDGEARLAAdvgaymQTLLLAMTAYGVD 171
Cdd:cd02137   69 ---------------------------------TA----------SAVILVLGDLNAGLAA------MNLMLAAKAKGYD 99

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 664518790 172 SCPQGllSFYADTVRTELGVTGGKLLV-GISFGYADEAAP 210
Cdd:cd02137  100 TCPMG--GFDKEKVAELLNLPDRYVPVlLIAIGKAADKAP 137
nitroreductase cd03370
uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus ...
 17-218 1.24e-11

uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus thermophilus NADH oxidase and other, uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380327 [Multi-domain]  Cd Length: 191  Bit Score: 61.18  E-value: 1.24e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  17 IRGRHASRAFRPEPVPEDTMRRIFSLAGAAPSNSNAQPWQVEVVSGAARRR--LADALRSAHAEGRTSVDFPYS--EEMY 92
Cdd:cd03370    5 IESRRSIRKYTQEPVPDEDLREILRLAGLAPSAWNIQPWRFVVVRDAELKEqlQAAAYGQAQVTSAPAVIVIYSdmEDAL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  93 APVHQS--------RRAAFGAELYGALGIGPDDhpARAAYdaesldfygaphaaflfvdGDGEARLAadvgayMQTLLLA 164
Cdd:cd03370   85 ANLEETihpglseeRRQREAAGLRGAFGKMSVE--QRGQW-------------------GLAQANIA------LGFLLLA 137

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 664518790 165 MTAYGVDSCPqgLLSFYADTVRTELGVTGGKLLVG-ISFGYADEAA-PVNRVRTER 218
Cdd:cd03370  138 AQSLGYDTSP--MLGFDPEKVKALLGLPEHVTIAAlVALGKPAEEGyPHHRHSLER 191
YdjA-like cd02135
nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the ...
 15-204 1.56e-11

nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.


Pssm-ID: 380312 [Multi-domain]  Cd Length: 162  Bit Score: 60.31  E-value: 1.56e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  15 KLIRGRHASRAFR-PEPVPEDTMRRIFSLAGAAPSNSNAQPWQVEVVSGAARRRLADALRSAHAEGrtsvDFPYSEEMYA 93
Cdd:cd02135    2 ELIKTRRSIRKFKlTGAPPEEQLEELLEAAMWAPNHGKLEPWRFIVVTGEGRERLAELLAAAAAAR----APGADPEKLE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  94 pvhQSRRAAFGAELYGALGIGPDDHPARAAYdaesldfygaphaaflfvdgdgEARLAadVGAYMQTLLLAMTAYGVDSC 173
Cdd:cd02135   78 ---KAREKALRAPVVIAVVAKPDEDPKVPEW----------------------EQYAA--VGAAVQNLLLAAHALGLGAV 130

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 664518790 174 pqgLLS---FYADTVRTELGVTGGKLLVG-ISFGY 204
Cdd:cd02135  131 ---WRTgpvTYDPAVREALGLPEDERIVGfLYLGT 162
nitroreductase cd02139
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 17-210 4.27e-11

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380316 [Multi-domain]  Cd Length: 165  Bit Score: 59.41  E-value: 4.27e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  17 IRGRHASRAFRPEPVPEDTMRRIFSLAGAAPSNSNAQPWQVEVVSGAA-RRRLADALRSAHAegrtsvdfpYSEemyAPV 95
Cdd:cd02139    5 IKKRRSIRKYKPTPVEEEKLLRILEAARLAPSAKNRQPWRFIVVKDKElKEKLAEAANGQKF---------IAE---APV 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  96 HqsrraafgaelygALGIG-PDDHparaaydaesldfygaphaaflfVDGDGEARLAADVGAYMQTLLLAMTAYGVDSCP 174
Cdd:cd02139   73 V-------------IVACAdPSES-----------------------GMGCGKPYYLVDVAIAMEHLVLAATEEGLGTCW 116

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 664518790 175 QGllSFYADTVRTELGVTGGKLLVGI-SFGYADEAAP 210
Cdd:cd02139  117 IG--AFDEDKVKEILGIPEEYRVVALtPLGYPAEEPP 151
PRK13294 PRK13294
F420-0--gamma-glutamyl ligase; Provisional
 11-210 1.13e-09

F420-0--gamma-glutamyl ligase; Provisional


Pssm-ID: 183957 [Multi-domain]  Cd Length: 448  Bit Score: 57.33  E-value: 1.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  11 GSAEKLIRGRHAS-------RAFRPEPVPEDTMRRIFSLAGAAPSNSNAQPWQ-VEVVSGAARRRLADALRSAHAEGRTS 82
Cdd:PRK13294 244 GTAEALELGRREAvllrrsvREFSDDPVDPEAVRRAVAAALTAPAPHHTRPVRfVWLRSAAVRTRLLDAMRDAWRADLRA 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  83 VDFpySEEMYApvhqsRRAAFGAELYGA--------LGIGPDDHPARAAYDAESLDFYGAphaaflfvdgdgearlaadV 154
Cdd:PRK13294 324 DGL--SEESIA-----RRVRRGDILYDApelvvpflVPDGAHSYPDARRTAAERTMFTVA-------------------V 377

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 664518790 155 GAYMQTLLLAMTAYGVDSCPQGLLSFYADTVRTELGVTGGKLLVG-ISFGYADEAAP 210
Cdd:PRK13294 378 GAAVQNLLVALAVEGLGSCWIGSTIFAADVVRAVLDLPADWEPLGaVAIGHPAEPPG 434
BluB cd02145
5,6-dimethylbenzimidazole synthase; BluB catalyzes the O2-dependent conversion of FMNH2 to 5, ...
 15-78 2.30e-09

5,6-dimethylbenzimidazole synthase; BluB catalyzes the O2-dependent conversion of FMNH2 to 5,6-dimethylbenzimidazole (DMB), a component of vitamin B12; is is a subfamily of the nitroreductase family; nitroreductases typically reduce their substrates by using NAD(P)H as electron donor and often use FMN as a cofactor.


Pssm-ID: 380321  Cd Length: 196  Bit Score: 55.06  E-value: 2.30e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 664518790  15 KLIRGRHASRAFRPEPVPEDTMRRIFSLAGAAPSNSNAQPWQ-VEVVSGAARRRLADALRSAHAE 78
Cdd:cd02145    2 RVIRWRRDVRHFRPDPVPEEVLERLLQAAHLAPSVGLMQPWRfVRVRSAATRKAVHELFQRANAE 66
nitroreductase_FeS-like cd02143
nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family ...
 16-93 5.65e-09

nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family utilize FMN as a cofactor. This family may be involved in the reduction of flavin or nitroaromatic compounds via an obligatory two-electron transfer. Nitroreductase is homodimer. Each subunit contains one FMN molecule.


Pssm-ID: 380319 [Multi-domain]  Cd Length: 187  Bit Score: 54.02  E-value: 5.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  16 LIRGRHASRAFRPEPVPEDTMRRIFSLAGAAPSNSNAQPWQVEVVSGAAR-RRLA----DALRSAHAEGRTSVDFPYSEE 90
Cdd:cd02143    1 LLRSRRSIRRYKDKPVPRETLEKLLDIARYAPTGHNSQPVHWLVVDDPEKvRRLAelviDWMRELIKEDPELAGKLFLDG 80


                 ...
gi 664518790  91 MYA 93
Cdd:cd02143   81 IVA 83
BluB TIGR02476
5,6-dimethylbenzimidazole synthase; A previously published hypothesis that BluB, involved in ...
 15-72 1.15e-08

5,6-dimethylbenzimidazole synthase; A previously published hypothesis that BluB, involved in cobalamin biosynthesis, is EC 1.16.8.1 (cob(II)yrinic acid a,c-diamide reductase) is now contradicted by newer work ascribing a role in 5,6-dimethylbenzimidazole (DMB) biosynthesis. The BluB protein is related to the nitroreductase family (pfam0881). [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 162875  Cd Length: 205  Bit Score: 53.21  E-value: 1.15e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 664518790   15 KLIRGRHASRAFRPEPVPEDTMRRIFSLAGAAPSNSNAQPWQVEVVSGAARRRLADAL 72
Cdd:TIGR02476  11 RLIRERRDVRHFRSDPVPEAVLERLLDAAHHAPSVGFSQPWRFVRVESPATREAVHAL 68
nitroreductase cd20608
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 17-72 1.78e-07

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380329 [Multi-domain]  Cd Length: 145  Bit Score: 48.87  E-value: 1.78e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 664518790  17 IRGRHASRAFRPEPVPEDTMRRIFSLAGAAPSNSNAQPWQVEVV------------SGAARRRLADAL 72
Cdd:cd20608    4 IKTRRSVRRFSDKPVEEEKLEKILEAARLAPSWANKQCWRFIVVtdketlselakkESPSNGWLKDAP 71
nitroreductase cd02150
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 17-207 3.18e-07

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380325 [Multi-domain]  Cd Length: 156  Bit Score: 48.37  E-value: 3.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  17 IRGRHASRAFRPEPVPEDTMRRIFSLAGAAPSNSNAQPWQVEVVSgaaRRRLADALRSAHaegrtsvdfPYSEEMyapvh 96
Cdd:cd02150    1 ILTRRSIRKYTDKPVEEEDIEKLLRAAMAAPSAGNQQPWHFIVVT---DREKLDKIAEAH---------PYGKML----- 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  97 qsrraafgaelygalgigpddhparaaydaesldfYGAPHAafLFVDGDGEARLA-----ADVGAYMQTLLLAMTAYGVD 171
Cdd:cd02150   64 -----------------------------------KEAPLA--IVVCGDPSKEKApgywvQDCSAATENILLAAHALGLG 106

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 664518790 172 SCpqgLLSFYAD-----TVRTELGVTGG-KLLVGISFGYADE 207
Cdd:cd02150  107 AV---WLGVYPFeervkAIREILNIPENiIPFCVIALGYPAE 145
TdsD-like cd02138
nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase ...
 16-55 3.90e-07

nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to Burkholderia pseudomallei TdsD, may be involved in the processing of organosulfur compounds. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380315 [Multi-domain]  Cd Length: 174  Bit Score: 48.31  E-value: 3.90e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 664518790  16 LIRGRHASRAFRPEPVPEDTMRRIFSLAGAAPSNSNAQPW 55
Cdd:cd02138    1 LIAERWSPRAFSPEPISEEDLLSLFEAARWAPSCFNEQPW 40
NfsA-like cd02146
nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin ...
 21-224 9.06e-07

nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.


Pssm-ID: 380322 [Multi-domain]  Cd Length: 229  Bit Score: 48.00  E-value: 9.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  21 HAS-RAFRPEPVPEDTMRRIFSLAGAAPSNSNAQPWQVEVVSGAARR-RLAdalrsahaegRTSVDFPYSEEmyAPVH-- 96
Cdd:cd02146    8 HRSvRKFTDEPLTDETLETLIAAAQSASTSSNLQAYSVIVVTDPELReKLA----------ELAGNQPYVAQ--APVFlv 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  97 ---QSRRAAFGAELYGALGIGPDdhparaayDAESLdfygaphaAFLFVDgdgeARLAAdvgaymQTLLLAMTAYGVDSC 173
Cdd:cd02146   76 fcaDLYRHQKIAEEAGGKDVGLD--------YLESF--------LVGVVD----AALAA------QNALVAAESLGLGIV 129

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 664518790 174 PQGLLSFYADTVRTELGVTGGKL-LVGISFGYADEAAPVNrvrtERAPFEAT 224
Cdd:cd02146  130 YIGGIRNNPEEVIELLGLPEYVFpLFGLTVGHPDPTPEVK----PRLPLEAV 177
nitroreductase cd20609
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 15-71 1.27e-06

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380330 [Multi-domain]  Cd Length: 145  Bit Score: 46.61  E-value: 1.27e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 664518790  15 KLIRGRHASRAFRPEPVPEDTMRRIFSLAGAAPSNSNAQPWQVEVV-SGAARRRLADA 71
Cdd:cd20609    4 ELAKKRYSVRKFSDKPVEKEKLDKILEAGRLAPTAVNYQPQRILVVrSEEALEKLAKA 61
iodotyrosine_dehalogenase cd02144
iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the ...
 15-67 1.69e-06

iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers.


Pssm-ID: 380320  Cd Length: 192  Bit Score: 46.76  E-value: 1.69e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 664518790  15 KLIRGRHASRAFRPEPVPEDTMRRIFSLAGAAPSNSNAQPWQVEVVSGAARRR 67
Cdd:cd02144    3 ELMKKRRSVRDFSSEPVPREVIENAIRTAGTAPSGANTQPWTFVVVSDPEIKR 55
nitroreductase cd02151
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 16-61 1.90e-06

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers..


Pssm-ID: 380326 [Multi-domain]  Cd Length: 157  Bit Score: 46.37  E-value: 1.90e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 664518790  16 LIRGRHASRAFRPEPVPEDTMRRIFSLAGAAPSNSNAQPWQVEVVS 61
Cdd:cd02151    2 LLKKRRSIRKYTDEPIEEEKLEEILEAALLAPSSRNSRPVEFIVVD 47
RutE-like cd02148
nitroreductase similar to Escherichia coli RutE; A subfamily of the nitroreductase family ...
 12-72 6.08e-05

nitroreductase similar to Escherichia coli RutE; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. RutE is involved in the utilization of uracil as the sole nitrogen source; it appears to have the same function as YdfG, which reduces malonic semialdehyde to 3-hydroxypropionic acid.


Pssm-ID: 380323 [Multi-domain]  Cd Length: 186  Bit Score: 42.24  E-value: 6.08e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 664518790  12 SAEKLIRGRHASRAFRPEPVPEDTMRRIFSLAGAAPSNSNAQPWQ-VEVVSGAARRRLADAL 72
Cdd:cd02148    1 ALDQLFTEARTHNAWEDKPVSDEELRAIYDLAKWGPTAANCSPARiVFVRSAEAKERLVPHL 62
PRK05365 PRK05365
malonic semialdehyde reductase; Provisional
 14-72 8.00e-05

malonic semialdehyde reductase; Provisional


Pssm-ID: 180040 [Multi-domain]  Cd Length: 195  Bit Score: 42.11  E-value: 8.00e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  14 EKLIRGRHASRAFRPEPVPEDTMRRIFSLAGAAPSNSNAQPWQ-VEVVSGAARRRLADAL 72
Cdd:PRK05365  10 DQLFTEARTHNGWLDEPVSDEQLRELYDLVKWGPTSANCSPARfVFVRSAEAKERLRPAL 69
PRK11053 PRK11053
oxygen-insensitive NAD(P)H nitroreductase;
16-207 1.84e-04

oxygen-insensitive NAD(P)H nitroreductase;


Pssm-ID: 182929 [Multi-domain]  Cd Length: 217  Bit Score: 41.11  E-value: 1.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  16 LIRGRHASRAFRPE-PVPEDTMRRIFSLAGAAPSNSNAQPWQVEVVSGA-ARRRLADALRSAHAEG-------------- 79
Cdd:PRK11053   6 VAKKRYTTKAFDPSkKLPAEQIEQIKTLLRFSPSSVNSQPWHFIVASTEeGKARIAKAAAGNYAFNerkildashvvvfc 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  80 -RTSVDFPY---------------SEEMYAPVHQSRRaaFGAELYgalgigpddhparaAYDAESLDFYgaphaaflfvd 143
Cdd:PRK11053  86 aKTDMDDAYlelvleqedadgrfaTEEAKAAQDKGRR--FFADMH--------------RKELKDLQHW----------- 138

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 664518790 144 gdGEARLAADVGaymqTLLLAMTAYGVDSCPQGllSFYADTVRTELGVT--GGKLLVGISFGYADE 207
Cdd:PRK11053 139 --MEKQVYLALG----NLLLGAAALGIDATPIE--GFDAAILDAEFGLRekGLTSSVVVPLGYHSE 196
PRK07877 PRK07877
Rv1355c family protein;
28-125 5.14e-04

Rv1355c family protein;


Pssm-ID: 236122 [Multi-domain]  Cd Length: 722  Bit Score: 40.74  E-value: 5.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  28 PEPVPEDTMRRIFSLAGAAPSNSNAQPWQVEVVsgaarrrlADALRSAHAEGRTS-VDFPY---SEEMYAPVHQSRRAAF 103
Cdd:PRK07877 369 AEALPQDALEIVAAAAIRAPSGGNVQPWHIEAD--------QDRLTIRLAPEHTSaMDVGYrgsAVAVGAALFNARVAAA 440

                         90       100
                 ....*....|....*....|....
gi 664518790 104 GAELYGA--LGIGPDDHPARAAYD 125
Cdd:PRK07877 441 AHGLLGPveFFPGDEGSPLRATLR 464
NfsB-like cd02149
nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This ...
 20-71 5.63e-04

nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family includes FRase I in Vibrio fischeri, wihich reduces FMN into FMNH2 as part of the bioluminescent reaction. The family also includes oxygen-insensitive nitroreductases that use NADH or NADPH as an electron donor in the ping pong bi bi mechanism. This type of nitroreductase can be used in cancer chemotherapy to activate a range of prodrugs.


Pssm-ID: 380324 [Multi-domain]  Cd Length: 156  Bit Score: 39.16  E-value: 5.63e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 664518790  20 RHASRAFRPE-PVPEDTMRRIFSLAGAAPSNSNAQPWQVEVV-SGAARRRLADA 71
Cdd:cd02149    9 RYATKKFDPNkKISDEDLETILEALRLSPSSFGLEPWKFLVVeNPELKAKLAPA 62
FbiB_C-like cd20607
nitroreductase family domain similar to the C-terminal domain of F420:gamma-glutamyl ligase ...
 52-210 7.38e-03

nitroreductase family domain similar to the C-terminal domain of F420:gamma-glutamyl ligase FbiB; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Mycobacterium tuberculosis FbiB, is a two-domain protein and produces F420 with predominantly 5 to 7 L-glutamate residues in the poly-gamma-glutamate tail, its C-terminal domain is homologous to FMN-dependent nitroreductases.


Pssm-ID: 380328 [Multi-domain]  Cd Length: 155  Bit Score: 35.91  E-value: 7.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790  52 AQPWQ-VEVVSGAARRRLADALRSAHAEGRTSVDFPyseemyaPVHQSRRAAFGAELYGALGI--------GPDDHPARA 122
Cdd:cd20607    4 TRPWRfVWLQDPAIRKELLDRMADRWEADLTGDGLT-------PEAIARRVSRGQILYDAPEVvipflvpdGAHTYPDAR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664518790 123 AYDAESLDFYGAphaaflfvdgdgearlaadVGAYMQTLLLAMTAYGVDSCPQGLLSFYADTVRTELGVTGG-KLLVGIS 201
Cdd:cd20607   77 RTDAEHTMFTVA-------------------VGAAVQALLVALAVRGLGSCWIGSTIFAPDVVRDELDLPDDwEPLGAIA 137


                 ....*....
gi 664518790 202 FGYADEAAP 210
Cdd:cd20607  138 IGYPLEPPP 146
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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