NCBI Conserved Domain Search

Conserved domains on [gi|664524730|ref|WP_031041252|]

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MULTISPECIES: bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase [Streptomyces]

Protein Classification

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase( domain architecture ID 11487154)

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase reversibly catalyzes oxidation of 5,10-methylene-THF to 5,10-methenyl-THF and hydrolysis of 5,10-methenyl-THF to 10-formyl-THF

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

PRK14193

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

1-284

0e+00

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 237637 [Multi-domain] Cd Length: 284 Bit Score: 551.16 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   1 MTAQILDGKATAAAIKSELTARVAALKERGVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEA 80
Cdd:PRK14193   1 MTAIILDGKATADEIKADLAERVAALKEKGITPGLGTVLVGDDPGSQAYVRGKHRDCAEVGITSIRRDLPADATQEELNA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  81 VVRELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPAPLPCTPHGILTLLRRHGVEIKGAE 160
Cdd:PRK14193  81 VIDELNADPACTGYIVQLPLPKHLDENAVLERIDPAKDADGLHPTNLGRLVLNEPAPLPCTPRGIVHLLRRYDVELAGAH 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 161 VVVVGRGVTIGRPMPLLLTRRSENATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSRNAEGK 240
Cdd:PRK14193 161 VVVIGRGVTVGRPIGLLLTRRSENATVTLCHTGTRDLAAHTRRADIIVAAAGVAHLVTADMVKPGAAVLDVGVSRAGDGK 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 664524730 241 IVGDVHPDVAEVAAWISPNPGGVGPMTRAQLLVNVVEAAERRAG 284
Cdd:PRK14193 241 LVGDVHPDVWEVAGAVSPNPGGVGPMTRAFLLTNVVERAERRAG 284

Name

Accession

Description

Interval

E-value

PRK14193

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

1-284

0e+00

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 237637 [Multi-domain] Cd Length: 284 Bit Score: 551.16 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   1 MTAQILDGKATAAAIKSELTARVAALKERGVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEA 80
Cdd:PRK14193   1 MTAIILDGKATADEIKADLAERVAALKEKGITPGLGTVLVGDDPGSQAYVRGKHRDCAEVGITSIRRDLPADATQEELNA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  81 VVRELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPAPLPCTPHGILTLLRRHGVEIKGAE 160
Cdd:PRK14193  81 VIDELNADPACTGYIVQLPLPKHLDENAVLERIDPAKDADGLHPTNLGRLVLNEPAPLPCTPRGIVHLLRRYDVELAGAH 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 161 VVVVGRGVTIGRPMPLLLTRRSENATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSRNAEGK 240
Cdd:PRK14193 161 VVVIGRGVTVGRPIGLLLTRRSENATVTLCHTGTRDLAAHTRRADIIVAAAGVAHLVTADMVKPGAAVLDVGVSRAGDGK 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 664524730 241 IVGDVHPDVAEVAAWISPNPGGVGPMTRAQLLVNVVEAAERRAG 284
Cdd:PRK14193 241 LVGDVHPDVWEVAGAVSPNPGGVGPMTRAFLLTNVVERAERRAG 284

FolD

COG0190

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase ...

1-284

2.44e-176

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism];

Pssm-ID: 439960 [Multi-domain] Cd Length: 285 Bit Score: 487.60 E-value: 2.44e-176

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   1 MTAQILDGKATAAAIKSELTARVAALKERGVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEA 80
Cdd:COG0190    1 MMAQILDGKAVAAEIREELKERVAALKAKGITPGLAVVLVGDDPASQVYVRNKHKACEEVGIESELIRLPADTTQEELLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  81 VVRELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPAPLPCTPHGILTLLRRHGVEIKGAE 160
Cdd:COG0190   81 LIDELNADPSVHGILVQLPLPKHIDEEAVLEAIDPEKDVDGFHPVNLGRLVLGEPGFVPCTPAGIMELLERYGIDLAGKH 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 161 VVVVGRGVTIGRPMPLLLTRRseNATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSRNAEGK 240
Cdd:COG0190  161 AVVVGRSNIVGKPLALLLLRR--NATVTVCHSRTKDLAEHTRQADILVAAVGKPGLITADMVKPGAVVIDVGINRVEDGK 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 664524730 241 IVGDVH-PDVAEVAAWISPNPGGVGPMTRAQLLVNVVEAAERRAG 284
Cdd:COG0190  239 LVGDVDfESVAEKASAITPVPGGVGPMTIAMLLENTLKAAERQAG 283

THF_DHG_CYH_C

pfam02882

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;

123-283

4.10e-84

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;

Pssm-ID: 427036 Cd Length: 160 Bit Score: 249.30 E-value: 4.10e-84

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  123 HPMNLGRLVLNEPAPLPCTPHGILTLLRRHGVEIKGAEVVVVGRGVTIGRPMPLLLTRRseNATVTQCHTGTRDLAAHLR 202
Cdd:pfam02882   1 HPYNLGRLVLGKPCFVPCTPRGIMELLKRYGIDLAGKNVVVVGRSNIVGKPLALLLLNA--NATVTVCHSKTKDLAEITR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  203 RADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSRNAEGKIVGDVH-PDVAEVAAWISPNPGGVGPMTRAQLLVNVVEAAER 281
Cdd:pfam02882  79 EADIVVVAVGKPELIKADWIKPGAVVIDVGINRVGNGKLVGDVDfENVKEKASAITPVPGGVGPMTVAMLLQNTVEAAKR 158


                  ..
gi 664524730  282 RA 283
Cdd:pfam02882 159 QL 160

NAD_bind_m-THF_DH_Cyclohyd

cd01080

NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding ...

115-280

2.43e-78

NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding domain of the Methylene-Tetrahydrofolate Dehydrogenase/cyclohydrolase (m-THF DH/cyclohydrolase) bifunctional enzyme. Tetrahydrofolate is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. In addition, most DHs also have an associated cyclohydrolase activity which catalyzes its hydrolysis to N10-formyltetrahydrofolate. m-THF DH is typically found as part of a multifunctional protein in eukaryotes. NADP-dependent m-THF DH in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, monofucntional DH, as well as bifunctional m-THF m-THF DHm-THF DHDH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express an monofunctional DH. This family contains the bifunctional DH/cyclohydrolase. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains.

Pssm-ID: 133448 Cd Length: 168 Bit Score: 234.76 E-value: 2.43e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 115 PDKDADGLHPMNLGRLVLNEPAPLPCTPHGILTLLRRHGVEIKGAEVVVVGRGVTIGRPMPLLLTRRseNATVTQCHTGT 194
Cdd:cd01080    1 PEKDVDGLHPVNLGRLALGRPGFIPCTPAGILELLKRYGIDLAGKKVVVVGRSNIVGKPLAALLLNR--NATVTVCHSKT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 195 RDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSR---NAEGKIVGDVHPD-VAEVAAWISPNPGGVGPMTRAQ 270
Cdd:cd01080   79 KNLKEHTKQADIVIVAVGKPGLVKGDMVKPGAVVIDVGINRvpdKSGGKLVGDVDFEsAKEKASAITPVPGGVGPMTVAM 158

                        170
                 ....*....|
gi 664524730 271 LLVNVVEAAE 280
Cdd:cd01080  159 LMKNTVEAAK 168

Name

Accession

Description

Interval

E-value

PRK14193

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

1-284

0e+00

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 237637 [Multi-domain] Cd Length: 284 Bit Score: 551.16 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   1 MTAQILDGKATAAAIKSELTARVAALKERGVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEA 80
Cdd:PRK14193   1 MTAIILDGKATADEIKADLAERVAALKEKGITPGLGTVLVGDDPGSQAYVRGKHRDCAEVGITSIRRDLPADATQEELNA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  81 VVRELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPAPLPCTPHGILTLLRRHGVEIKGAE 160
Cdd:PRK14193  81 VIDELNADPACTGYIVQLPLPKHLDENAVLERIDPAKDADGLHPTNLGRLVLNEPAPLPCTPRGIVHLLRRYDVELAGAH 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 161 VVVVGRGVTIGRPMPLLLTRRSENATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSRNAEGK 240
Cdd:PRK14193 161 VVVIGRGVTVGRPIGLLLTRRSENATVTLCHTGTRDLAAHTRRADIIVAAAGVAHLVTADMVKPGAAVLDVGVSRAGDGK 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 664524730 241 IVGDVHPDVAEVAAWISPNPGGVGPMTRAQLLVNVVEAAERRAG 284
Cdd:PRK14193 241 LVGDVHPDVWEVAGAVSPNPGGVGPMTRAFLLTNVVERAERRAG 284

FolD

COG0190

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase ...

1-284

2.44e-176

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism];

Pssm-ID: 439960 [Multi-domain] Cd Length: 285 Bit Score: 487.60 E-value: 2.44e-176

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   1 MTAQILDGKATAAAIKSELTARVAALKERGVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEA 80
Cdd:COG0190    1 MMAQILDGKAVAAEIREELKERVAALKAKGITPGLAVVLVGDDPASQVYVRNKHKACEEVGIESELIRLPADTTQEELLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  81 VVRELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPAPLPCTPHGILTLLRRHGVEIKGAE 160
Cdd:COG0190   81 LIDELNADPSVHGILVQLPLPKHIDEEAVLEAIDPEKDVDGFHPVNLGRLVLGEPGFVPCTPAGIMELLERYGIDLAGKH 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 161 VVVVGRGVTIGRPMPLLLTRRseNATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSRNAEGK 240
Cdd:COG0190  161 AVVVGRSNIVGKPLALLLLRR--NATVTVCHSRTKDLAEHTRQADILVAAVGKPGLITADMVKPGAVVIDVGINRVEDGK 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 664524730 241 IVGDVH-PDVAEVAAWISPNPGGVGPMTRAQLLVNVVEAAERRAG 284
Cdd:COG0190  239 LVGDVDfESVAEKASAITPVPGGVGPMTIAMLLENTLKAAERQAG 283

PRK14190

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

1-284

2.34e-127

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 184560 [Multi-domain] Cd Length: 284 Bit Score: 363.56 E-value: 2.34e-127

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   1 MTAQILDGKATAAAIKSELTARVAALKERGVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEA 80
Cdd:PRK14190   1 MMAVIIDGKEVAKEKREQLKEEVVKLKEQGIVPGLAVILVGDDPASHSYVRGKKKAAEKVGIYSELYEFPADITEEELLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  81 VVRELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPAPLPCTPHGILTLLRRHGVEIKGAE 160
Cdd:PRK14190  81 LIDRLNADPRINGILVQLPLPKHIDEKAVIERISPEKDVDGFHPINVGRMMLGQDTFLPCTPHGILELLKEYNIDISGKH 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 161 VVVVGRGVTIGRPMPLLLTRrsENATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSRNAEGK 240
Cdd:PRK14190 161 VVVVGRSNIVGKPVGQLLLN--ENATVTYCHSKTKNLAELTKQADILIVAVGKPKLITADMVKEGAVVIDVGVNRLENGK 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 664524730 241 IVGDVHPD-VAEVAAWISPNPGGVGPMTRAQLLVNVVEAAERRAG 284
Cdd:PRK14190 239 LCGDVDFDnVKEKASYITPVPGGVGPMTITMLMHNTVELAKRAGG 283

PRK14189

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;

1-284

1.05e-114

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;

Pssm-ID: 184559 [Multi-domain] Cd Length: 285 Bit Score: 331.65 E-value: 1.05e-114

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   1 MTAQILDGKATAAAIKSELTARVAALKERGVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEA 80
Cdd:PRK14189   1 MTAQLIDGNALSKQLRAEAAQRAAALTARGHQPGLAVILVGDNPASQVYVRNKVKACEDNGFHSLKDRYPADLSEAELLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  81 VVRELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPAPLPCTPHGILTLLRRHGVEIKGAE 160
Cdd:PRK14189  81 RIDELNRDPKIHGILVQLPLPKHIDSHKVIEAIAPEKDVDGFHVANAGALMTGQPLFRPCTPYGVMKMLESIGIPLRGAH 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 161 VVVVGRGVTIGRPMPLLLTRRseNATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSRNAEGK 240
Cdd:PRK14189 161 AVVIGRSNIVGKPMAMLLLQA--GATVTICHSKTRDLAAHTRQADIVVAAVGKRNVLTADMVKPGATVIDVGMNRDDAGK 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 664524730 241 IVGDVHPD-VAEVAAWISPNPGGVGPMTRAQLLVNVVEAAERRAG 284
Cdd:PRK14189 239 LCGDVDFAgVKEVAGYITPVPGGVGPMTITMLLVNTIEAAERAAA 283

PRK10792

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

1-282

4.53e-114

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 236760 [Multi-domain] Cd Length: 285 Bit Score: 329.96 E-value: 4.53e-114

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   1 MTAQILDGKATAAAIKSELTARVAALKERGV-TPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIE 79
Cdd:PRK10792   1 MTAKIIDGKTIAQQVRSEVAQKVQARVAAGLrAPGLAVVLVGSDPASQVYVASKRKACEEVGFVSRSYDLPETTSEAELL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  80 AVVRELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPAPLPCTPHGILTLLRRHGVEIKGA 159
Cdd:PRK10792  81 ALIDELNADPTIDGILVQLPLPAHIDNVKVLERIHPDKDVDGFHPYNVGRLAQRIPLLRPCTPRGIMTLLERYGIDTYGL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 160 EVVVVGRGVTIGRPMP--LLLTRrsenATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSRNA 237
Cdd:PRK10792 161 NAVVVGASNIVGRPMSleLLLAG----CTVTVCHRFTKNLRHHVRNADLLVVAVGKPGFIPGEWIKPGAIVIDVGINRLE 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 664524730 238 EGKIVGDVHPDVA-EVAAWISPNPGGVGPMTRAQLLVNVVEAAERR 282
Cdd:PRK10792 237 DGKLVGDVEFETAaERASWITPVPGGVGPMTVATLLENTLQACEEY 282

PRK14186

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

2-284

1.87e-109

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 237636 [Multi-domain] Cd Length: 297 Bit Score: 318.55 E-value: 1.87e-109

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   2 TAQILDGKATAAAIKSELTARVAALKER-GVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEA 80
Cdd:PRK14186   1 MALILDGKALAAEIEQRLQAQIESNLPKaGRPPGLAVLRVGDDPASAVYVRNKEKACARVGIASFGKHLPADTSQAEVEA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  81 VVRELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPAPLPCTPHGILTLLRRHGVEIKGAE 160
Cdd:PRK14186  81 LIAQLNQDERVDGILLQLPLPKHLDEVPLLHAIDPDKDADGLHPLNLGRLVKGEPGLRSCTPAGVMRLLRSQQIDIAGKK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 161 VVVVGRGVTIGRPMPLLLtrRSENATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSR----N 236
Cdd:PRK14186 161 AVVVGRSILVGKPLALML--LAANATVTIAHSRTQDLASITREADILVAAAGRPNLIGAEMVKPGAVVVDVGIHRlpssD 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 664524730 237 AEGKIVGDV-HPDVAEVAAWISPNPGGVGPMTRAQLLVNVVEAAERRAG 284
Cdd:PRK14186 239 GKTRLCGDVdFEEVEPVAAAITPVPGGVGPMTVTMLLVNTVLSWQKRHG 287

PRK14184

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

4-284

1.72e-105

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 237635 [Multi-domain] Cd Length: 286 Bit Score: 308.24 E-value: 1.72e-105

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   4 QILDGKATAAAIKSELTARVAALKER-GVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEAVV 82
Cdd:PRK14184   2 LLLDGKATAATIREELKTEVAALTARhGRAPGLAVILVGEDPASQVYVRNKERACEDAGIVSEAFRLPADTTQEELEDLI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  83 RELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPAPLPCTPHGILTLLRRHGVEIKGAEVV 162
Cdd:PRK14184  82 AELNARPDIDGILLQLPLPKGLDSQRCLELIDPAKDVDGFHPENMGRLALGLPGFRPCTPAGVMTLLERYGLSPAGKKAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 163 VVGRGVTIGRPMPLLLTRRSE--NATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSRNAEGk 240
Cdd:PRK14184 162 VVGRSNIVGKPLALMLGAPGKfaNATVTVCHSRTPDLAEECREADFLFVAIGRPRFVTADMVKPGAVVVDVGINRTDDG- 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 664524730 241 IVGDV-HPDVAEVAAWISPNPGGVGPMTRAQLLVNVVEAAERRAG 284
Cdd:PRK14184 241 LVGDCdFEGLSDVASAITPVPGGVGPMTIAQLLVNTVQSWKERVG 285

PRK14188

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

2-284

2.16e-102

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 184558 [Multi-domain] Cd Length: 296 Bit Score: 300.72 E-value: 2.16e-102

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   2 TAQILDGKATAAAIKSELTARVAALKER-GVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEA 80
Cdd:PRK14188   1 MATIIDGKAFAADVRATVAAEVARLKAAhGVTPGLAVVLVGEDPASQVYVRSKGKQTKEAGMASFEHKLPADTSQAELLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  81 VVRELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPAPLPCTPHGILTLLRRHGVEIKGAE 160
Cdd:PRK14188  81 LIARLNADPAIHGILVQLPLPKHLDSEAVIQAIDPEKDVDGLHVVNAGRLATGETALVPCTPLGCMMLLRRVHGDLSGLN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 161 VVVVGRGVTIGRPMPLLLTRrsENATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSR----- 235
Cdd:PRK14188 161 AVVIGRSNLVGKPMAQLLLA--ANATVTIAHSRTRDLPAVCRRADILVAAVGRPEMVKGDWIKPGATVIDVGINRipape 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 664524730 236 NAEGK--IVGDVHPD-VAEVAAWISPNPGGVGPMTRAQLLVNVVEAAERRAG 284
Cdd:PRK14188 239 KGEGKtrLVGDVAFAeAAEVAGAITPVPGGVGPMTIACLLANTLTAACRAAG 290

PRK14191

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

4-283

2.71e-100

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172679 [Multi-domain] Cd Length: 285 Bit Score: 295.14 E-value: 2.71e-100

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   4 QILDGKATAAAIKSELTARVAALK-ERGVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEAVV 82
Cdd:PRK14191   2 VLLDGKALSYKIEKDLKNKIQILTaQTGKRPKLAVILVGKDPASQTYVNMKIKACERVGMDSDLHTLQENTTEAELLSLI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  83 RELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPAPLPCTPHGILTLLRRHGVEIKGAEVV 162
Cdd:PRK14191  82 KDLNTDQNIDGILVQLPLPRHIDTKMVLEAIDPNKDVDGFHPLNIGKLCSQLDGFVPATPMGVMRLLKHYHIEIKGKDVV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 163 VVGRGVTIGRPMPLLLTrrSENATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSRNAEGKIV 242
Cdd:PRK14191 162 IIGASNIVGKPLAMLML--NAGASVSVCHILTKDLSFYTQNADIVCVGVGKPDLIKASMVKKGAVVVDIGINRLNDGRLV 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 664524730 243 GDVHPD-VAEVAAWISPNPGGVGPMTRAQLLVNVVEAAERRA 283
Cdd:PRK14191 240 GDVDFEnVAPKASFITPVPGGVGPMTIVSLLENTLIAAEKRQ 281

PRK14167

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

3-284

2.44e-96

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 184549 [Multi-domain] Cd Length: 297 Bit Score: 285.52 E-value: 2.44e-96

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   3 AQILDGKATAAAIKSELTARVAALKERGVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEAVV 82
Cdd:PRK14167   2 TEIIDGNAVAAQIRDDLTDAIETLEDAGVTPGLATVLMSDDPASETYVSMKQRDCEEVGIEAIDVEIDPDAPAEELYDTI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  83 RELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPAPLPCTPHGILTLLRRHGVEIKGAEVV 162
Cdd:PRK14167  82 DELNADEDVHGILVQMPVPDHVDDREVLRRIDPAKDVDGFHPENVGRLVAGDARFKPCTPHGIQKLLAAAGVDTEGADVV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 163 VVGRGVTIGRPMPLLLTRRSE--NATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSR----N 236
Cdd:PRK14167 162 VVGRSDIVGKPMANLLIQKADggNATVTVCHSRTDDLAAKTRRADIVVAAAGVPELIDGSMLSEGATVIDVGINRvdadT 241

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 664524730 237 AEG-KIVGDVHPDVA-EVAAWISPNPGGVGPMTRAQLLVNVVEAAERRAG 284
Cdd:PRK14167 242 EKGyELVGDVEFESAkEKASAITPVPGGVGPMTRAMLLYNTVKAASLQEG 291

PRK14183

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

4-283

9.32e-94

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 184555 [Multi-domain] Cd Length: 281 Bit Score: 278.25 E-value: 9.32e-94

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   4 QILDGKATAAAIKSELTARVAALK-ERGVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEAVV 82
Cdd:PRK14183   2 QILDGKALSDKIKENVKKEVDELKlVKNIVPGLAVILVGDDPASHTYVKMKAKACDRVGIYSITHEMPSTISQKEILETI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  83 RELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPAPLPCTPHGILTLLRRHGVEIKGAEVV 162
Cdd:PRK14183  82 AMMNNNPNIDGILVQLPLPKHIDTTKILEAIDPKKDVDGFHPYNVGRLVTGLDGFVPCTPLGVMELLEEYEIDVKGKDVC 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 163 VVGRGVTIGRPMPLLLTRRseNATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSRNAEGKIV 242
Cdd:PRK14183 162 VVGASNIVGKPMAALLLNA--NATVDICHIFTKDLKAHTKKADIVIVGVGKPNLITEDMVKEGAIVIDIGINRTEDGRLV 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 664524730 243 GDV-HPDVAEVAAWISPNPGGVGPMTRAQLLVNVVEAAERRA 283
Cdd:PRK14183 240 GDVdFENVAKKCSYITPVPGGVGPMTIAMLLSNTLKAAKNRA 281

PRK14173

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

1-284

1.02e-93

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 184551 [Multi-domain] Cd Length: 287 Bit Score: 278.25 E-value: 1.02e-93

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   1 MTAQILDGKATAAAIKSELTARVAALKERgvtPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEA 80
Cdd:PRK14173   1 MAARELSGPPAAEAVYAELRARLAKLPFV---PHLRVVRLGEDPASVSYVRLKDRQAKALGLRSQVEVLPESTSQEELLE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  81 VVRELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPAPLPCTPHGILTLLRRHGVEIKGAE 160
Cdd:PRK14173  78 LIARLNADPEVDGILVQLPLPPHIDFQRVLEAIDPLKDVDGFHPLNVGRLWMGGEALEPCTPAGVVRLLKHYGIPLAGKE 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 161 VVVVGRGVTIGRPMPLLLTRrsENATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSR--NAE 238
Cdd:PRK14173 158 VVVVGRSNIVGKPLAALLLR--EDATVTLAHSKTQDLPAVTRRADVLVVAVGRPHLITPEMVRPGAVVVDVGINRvgGNG 235

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 664524730 239 GK--IVGDVHPDVAEVAAWISPNPGGVGPMTRAQLLVNVVEAAERRAG 284
Cdd:PRK14173 236 GRdiLTGDVHPEVAEVAGALTPVPGGVGPMTVAMLMANTVIAALRRRG 283

PRK14179

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;

3-283

1.61e-93

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;

Pssm-ID: 237634 [Multi-domain] Cd Length: 284 Bit Score: 277.79 E-value: 1.61e-93

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   3 AQILDGKATAAAIKSELTARVAALKER-GVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEAV 81
Cdd:PRK14179   2 TEIIDGKALAQKMQAELAEKVAKLKEEkGIVPGLVVILVGDNPASQVYVRNKERSALAAGFKSEVVRLPETISQEELLDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  82 VRELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPAPLPCTPHGILTLLRRHGVEIKGAEV 161
Cdd:PRK14179  82 IERYNQDPTWHGILVQLPLPKHINEEKILLAIDPKKDVDGFHPMNTGHLWSGRPVMIPCTPAGIMEMFREYNVELEGKHA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 162 VVVGRGVTIGRPMPLLLTRRseNATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSRNAEGKI 241
Cdd:PRK14179 162 VVIGRSNIVGKPMAQLLLDK--NATVTLTHSRTRNLAEVARKADILVVAIGRGHFVTKEFVKEGAVVIDVGMNRDENGKL 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 664524730 242 VGDVHPD-VAEVAAWISPNPGGVGPMTRAQLLVNVVEAAERRA 283
Cdd:PRK14179 240 IGDVDFDeVAEVASYITPVPGGVGPMTITMLMEQTYQAALRSL 282

PRK14176

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

5-281

2.21e-92

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 184553 [Multi-domain] Cd Length: 287 Bit Score: 275.15 E-value: 2.21e-92

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   5 ILDGKATAAAIKSELTARVAALK-ERGVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEAVVR 83
Cdd:PRK14176  10 IIDGKALAKKIEAEVRSGVERLKsNRGITPGLATILVGDDPASKMYVRLKHKACERVGIRAEDQFLPADTTQEELLELID 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  84 ELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPAPLPCTPHGILTLLRRHGVEIKGAEVVV 163
Cdd:PRK14176  90 SLNKRKDVHGILLQLPLPKHLDPQEAMEAIDPAKDADGFHPYNMGKLMIGDEGLVPCTPHGVIRALEEYGVDIEGKNAVI 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 164 VGRGVTIGRPMPLLLTRRseNATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSRNaEGKIVG 243
Cdd:PRK14176 170 VGHSNVVGKPMAAMLLNR--NATVSVCHVFTDDLKKYTLDADILVVATGVKHLIKADMVKEGAVIFDVGITKE-EDKVYG 246

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 664524730 244 DVHPD-VAEVAAWISPNPGGVGPMTRAQLLVNVVEAAER 281
Cdd:PRK14176 247 DVDFEnVIKKASLITPVPGGVGPLTIAMLMKHVLMCAEK 285

PRK14166

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

5-282

1.60e-90

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 172654 [Multi-domain] Cd Length: 282 Bit Score: 269.97 E-value: 1.60e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   5 ILDGKATAAAIKSELTARVAALKERGVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEAVVRE 84
Cdd:PRK14166   3 LLDGKALSAKIKEELKEKNQFLKSKGIESCLAVILVGDNPASQTYVKSKAKACEECGIKSLVYHLNENTTQNELLALINT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  85 LNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLN-EPAPLPCTPHGILTLLRRHGVEIKGAEVVV 163
Cdd:PRK14166  83 LNHDDSVHGILVQLPLPDHICKDLILESIISSKDVDGFHPINVGYLNLGlESGFLPCTPLGVMKLLKAYEIDLEGKDAVI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 164 VGRGVTIGRPMPLLLTrrSENATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSRNAEGKIVG 243
Cdd:PRK14166 163 IGASNIVGRPMATMLL--NAGATVSVCHIKTKDLSLYTRQADLIIVAAGCVNLLRSDMVKEGVIVVDVGINRLESGKIVG 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 664524730 244 DVH-PDVAEVAAWISPNPGGVGPMTRAQLLVNVVEAAERR 282
Cdd:PRK14166 241 DVDfEEVSKKSSYITPVPGGVGPMTIAMLLENTVKSAKNR 280

PRK14178

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

5-284

2.27e-88

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172666 [Multi-domain] Cd Length: 279 Bit Score: 264.40 E-value: 2.27e-88

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   5 ILDGKATAAaikSELTARVAALKERGVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEAVVRE 84
Cdd:PRK14178   2 ILDGKAVSE---KRLELLKEEIIESGLYPRLATVIVGDDPASQMYVRMKHRACERVGIGSVGIELPGDATTRTVLERIRR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  85 LNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPAPLPCTPHGILTLLRRHGVEIKGAEVVVV 164
Cdd:PRK14178  79 LNEDPDINGILVQLPLPKGVDTERVIAAILPEKDVDGFHPLNLGRLVSGLPGFAPCTPNGIMTLLHEYKISIAGKRAVVV 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 165 GRGVTIGRPMPLLLTrrSENATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSRnAEGKIVGD 244
Cdd:PRK14178 159 GRSIDVGRPMAALLL--NADATVTICHSKTENLKAELRQADILVSAAGKAGFITPDMVKPGATVIDVGINQ-VNGKLCGD 235

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 664524730 245 VHPD-VAEVAAWISPNPGGVGPMTRAQLLVNVVEAAERRAG 284
Cdd:PRK14178 236 VDFDaVKEIAGAITPVPGGVGPMTIATLMENTFDAAKMRCC 276

PLN02516

methylenetetrahydrofolate dehydrogenase (NADP+)

2-281

4.51e-88

methylenetetrahydrofolate dehydrogenase (NADP+)

Pssm-ID: 178131 [Multi-domain] Cd Length: 299 Bit Score: 264.45 E-value: 4.51e-88

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   2 TAQILDGKATAAAIKSELTARVAALKER-GVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEA 80
Cdd:PLN02516   8 VAQIIDGKAIAKAIRSEIAEEVAQLSEKhGKVPGLAVVIVGSRKDSQTYVNMKRKACAEVGIKSFDVDLPENISEAELIS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  81 VVRELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLN--EPAPLPCTPHGILTLLRRHGVEIKG 158
Cdd:PLN02516  88 KVHELNANPDVHGILVQLPLPKHINEEKILNEISLEKDVDGFHPLNIGKLAMKgrEPLFLPCTPKGCLELLSRSGIPIKG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 159 AEVVVVGRGVTIGRPMPLLLTRrsENATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGV----- 233
Cdd:PLN02516 168 KKAVVVGRSNIVGLPVSLLLLK--ADATVTVVHSRTPDPESIVREADIVIAAAGQAMMIKGDWIKPGAAVIDVGTnavsd 245

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 664524730 234 -SRNAEGKIVGDV-HPDVAEVAAWISPNPGGVGPMTRAQLLVNVVEAAER 281
Cdd:PLN02516 246 pSKKSGYRLVGDVdFAEVSKVAGWITPVPGGVGPMTVAMLLKNTVDGAKR 295

PRK14169

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

3-283

5.16e-88

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 184550 [Multi-domain] Cd Length: 282 Bit Score: 263.73 E-value: 5.16e-88

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   3 AQILDGKATAAAIKSELTARVAALKERGVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEAVV 82
Cdd:PRK14169   1 ATRLDGRAVSKKILADLKQTVAKLAQQDVTPTLAVVLVGSDPASEVYVRNKQRRAEDIGVRSLMFRLPEATTQADLLAKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  83 RELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPAPLPCTPHGILTLLRRHGVEIKGAEVV 162
Cdd:PRK14169  81 AELNHDPDVDAILVQLPLPAGLDEQAVIDAIDPDKDVDGFSPVSVGRLWANEPTVVASTPYGIMALLDAYDIDVAGKRVV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 163 VVGRGVTIGRPMPLLLTrrSENATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSRNAEGKIV 242
Cdd:PRK14169 161 IVGRSNIVGRPLAGLMV--NHDATVTIAHSKTRNLKQLTKEADILVVAVGVPHFIGADAVKPGAVVIDVGISRGADGKLL 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 664524730 243 GDVHPD-VAEVAAWISPNPGGVGPMTRAQLLVNVVEAAERRA 283
Cdd:PRK14169 239 GDVDEAaVAPIASAITPVPGGVGPMTIASLMAQTVTLAKRRA 280

PRK14192

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

1-284

3.82e-86

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 184561 [Multi-domain] Cd Length: 283 Bit Score: 259.01 E-value: 3.82e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   1 MTAQILDGKATAAAIKSELTARVAALKER-GVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIE 79
Cdd:PRK14192   1 MMALVLDGKALAKQIEEELSVRVEALKAKtGRTPILATILVGDDPASATYVRMKGNACRRVGMDSLKVELPQETTTEQLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  80 AVVRELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPAPLPCTPHGILTLLRRHGVEIKGA 159
Cdd:PRK14192  81 AKIEELNANPDVHGILLQHPVPAQIDERACFDAISLAKDVDGVTCLGFGRMAMGEAAYGSATPAGIMRLLKAYNIELAGK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 160 EVVVVGRGVTIGRPMPLLLTrrSENATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSRNAEG 239
Cdd:PRK14192 161 HAVVVGRSAILGKPMAMMLL--NANATVTICHSRTQNLPELVKQADIIVGAVGKPELIKKDWIKQGAVVVDAGFHPRDGG 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 664524730 240 KiVGDVHPD-VAEVAAWISPNPGGVGPMTRAQLLVNVVEAAERRAG 284
Cdd:PRK14192 239 G-VGDIELQgIEEIASAYTPVPGGVGPMTINTLIRQTVEAAEKALG 283

PRK14174

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

4-281

8.10e-86

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 172662 [Multi-domain] Cd Length: 295 Bit Score: 258.60 E-value: 8.10e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   4 QILDGKATAAAIKSELTARVAALKER-GVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEAVV 82
Cdd:PRK14174   2 LIIDGKKVSLDLKNELKTRVEAYRAKtGKVPGLTVIIVGEDPASQVYVRNKAKSCKEIGMNSTVIELPADTTEEHLLKKI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  83 RELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLN--EPAPLPCTPHGILTLLRRHGVEIKGAE 160
Cdd:PRK14174  82 EDLNNDPDVHGILVQQPLPKQIDEFAVTLAIDPAKDVDGFHPENLGRLVMGhlDKCFVSCTPYGILELLGRYNIETKGKH 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 161 VVVVGRGVTIGRPMPLLLTR--RSENATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGV----- 233
Cdd:PRK14174 162 CVVVGRSNIVGKPMANLMLQklKESNCTVTICHSATKDIPSYTRQADILIAAIGKARFITADMVKPGAVVIDVGInried 241

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 664524730 234 -SRNAEGKIVGDVHPD-VAEVAAWISPNPGGVGPMTRAQLLVNVVEAAER 281
Cdd:PRK14174 242 pSTKSGYRLVGDVDYEgVSAKASAITPVPGGVGPMTIAMLLKNTLQSFER 291

PRK14168

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

1-279

9.29e-85

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 237633 [Multi-domain] Cd Length: 297 Bit Score: 255.96 E-value: 9.29e-85

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   1 MTAQILDGKATAAAIKSELTARVAALKER-GVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIE 79
Cdd:PRK14168   1 MSAKIIKGTEIREEILEEIRGEVAELKEKyGKVPGLVTILVGESPASLSYVTLKIKTAHRLGFHEIQDNQSVDITEEELL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  80 AVVRELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVL--NEPAPLPCTPHGILTLLRRHGVEIK 157
Cdd:PRK14168  81 ALIDKYNNDDSIHGILVQLPLPKHINEKKVLNAIDPDKDVDGFHPVNVGRLMIggDEVKFLPCTPAGIQEMLVRSGVETS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 158 GAEVVVVGRGVTIGRPMPLLLTRR--SENATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSR 235
Cdd:PRK14168 161 GAEVVVVGRSNIVGKPIANMMTQKgpGANATVTIVHTRSKNLARHCQRADILIVAAGVPNLVKPEWIKPGATVIDVGVNR 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 664524730 236 ----NAEGKIV--GDVHPD-VAEVAAWISPNPGGVGPMTRAQLLVNVVEAA 279
Cdd:PRK14168 241 vgtnESTGKAIlsGDVDFDaVKEIAGKITPVPGGVGPMTIAMLMRNTLKSA 291

PRK14182

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

5-283

2.72e-84

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 172670 [Multi-domain] Cd Length: 282 Bit Score: 254.18 E-value: 2.72e-84

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   5 ILDGKATAAAIKSELTARVAALKERGVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEAVVRE 84
Cdd:PRK14182   3 LIDGKQIAAKVKGEVATEVRALAARGVQTGLTVVRVGDDPASAIYVRGKRKDCEEVGITSVEHHLPATTTQAELLALIAR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  85 LNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPA-PLPCTPHGILTLLRRHGVEIKGAEVVV 163
Cdd:PRK14182  83 LNADPAVHGILVQLPLPKHVDERAVLDAISPAKDADGFHPFNVGALSIGIAGvPRPCTPAGVMRMLDEARVDPKGKRALV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 164 VGRGVTIGRPMPLLLTRRseNATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSRNAEGKIVG 243
Cdd:PRK14182 163 VGRSNIVGKPMAMMLLER--HATVTIAHSRTADLAGEVGRADILVAAIGKAELVKGAWVKEGAVVIDVGMNRLADGKLVG 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 664524730 244 DV-HPDVAEVAAWISPNPGGVGPMTRAQLLVNVVEAAERRA 283
Cdd:PRK14182 241 DVeFAAAAARASAITPVPGGVGPMTRAMLLVNTVELAKRTA 281

THF_DHG_CYH_C

pfam02882

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;

123-283

4.10e-84

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;

Pssm-ID: 427036 Cd Length: 160 Bit Score: 249.30 E-value: 4.10e-84

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  123 HPMNLGRLVLNEPAPLPCTPHGILTLLRRHGVEIKGAEVVVVGRGVTIGRPMPLLLTRRseNATVTQCHTGTRDLAAHLR 202
Cdd:pfam02882   1 HPYNLGRLVLGKPCFVPCTPRGIMELLKRYGIDLAGKNVVVVGRSNIVGKPLALLLLNA--NATVTVCHSKTKDLAEITR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  203 RADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSRNAEGKIVGDVH-PDVAEVAAWISPNPGGVGPMTRAQLLVNVVEAAER 281
Cdd:pfam02882  79 EADIVVVAVGKPELIKADWIKPGAVVIDVGINRVGNGKLVGDVDfENVKEKASAITPVPGGVGPMTVAMLLQNTVEAAKR 158


                  ..
gi 664524730  282 RA 283
Cdd:pfam02882 159 QL 160

PLN02616

tetrahydrofolate dehydrogenase/cyclohydrolase, putative

3-281

1.09e-83

tetrahydrofolate dehydrogenase/cyclohydrolase, putative

Pssm-ID: 215332 [Multi-domain] Cd Length: 364 Bit Score: 255.70 E-value: 1.09e-83

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   3 AQILDGKATAAAIKSELTARVAALKER-GVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEAV 81
Cdd:PLN02616  73 AKVIDGKAVAKKIRDEITIEVSRMKESiGVVPGLAVILVGDRKDSATYVRNKKKACDSVGINSFEVRLPEDSTEQEVLKF 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  82 VRELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVL--NEPAPLPCTPHGILTLLRRHGVEIKGA 159
Cdd:PLN02616 153 ISGFNNDPSVHGILVQLPLPSHMDEQNILNAVSIEKDVDGFHPLNIGRLAMrgREPLFVPCTPKGCIELLHRYNVEIKGK 232

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 160 EVVVVGRGVTIGRPMPLLLTRrsENATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGV-----S 234
Cdd:PLN02616 233 RAVVIGRSNIVGMPAALLLQR--EDATVSIVHSRTKNPEEITREADIIISAVGQPNMVRGSWIKPGAVVIDVGInpvedA 310

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 664524730 235 RNAEG-KIVGDV-HPDVAEVAAWISPNPGGVGPMTRAQLLVNVVEAAER 281
Cdd:PLN02616 311 SSPRGyRLVGDVcYEEACKVASAVTPVPGGVGPMTIAMLLSNTLTSAKR 359

PRK14175

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

1-284

4.73e-83

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 184552 [Multi-domain] Cd Length: 286 Bit Score: 251.37 E-value: 4.73e-83

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   1 MTAQILDGKATAAAIKSELTARVAALKERGVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEA 80
Cdd:PRK14175   1 MVAKILDGKQIAKDYRQGLQDQVEALKEKGFTPKLSVILVGNDGASQSYVRSKKKAAEKIGMISEIVHLEETATEEEVLN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  81 VVRELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPAPLPCTPHGILTLLRRHGVEIKGAE 160
Cdd:PRK14175  81 ELNRLNNDDSVSGILVQVPLPKQVSEQKILEAINPEKDVDGFHPINIGKLYIDEQTFVPCTPLGIMEILKHADIDLEGKN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 161 VVVVGRGVTIGRPMPLLLTRRseNATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSRNAEGK 240
Cdd:PRK14175 161 AVVIGRSHIVGQPVSKLLLQK--NASVTILHSRSKDMASYLKDADVIVSAVGKPGLVTKDVVKEGAVIIDVGNTPDENGK 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 664524730 241 IVGDV-HPDVAEVAAWISPNPGGVGPMTRAQLLVNVVEAAERRAG 284
Cdd:PRK14175 239 LKGDVdYDAVKEIAGAITPVPGGVGPLTITMVLNNTLLAEKMRRG 283

PRK14185

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

4-281

1.60e-81

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 184556 [Multi-domain] Cd Length: 293 Bit Score: 247.43 E-value: 1.60e-81

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   4 QILDGKATAAAIKSELTARVAALKERG-VTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEAVV 82
Cdd:PRK14185   2 QLIDGKAISAQIKQEIAAEVAEIVAKGgKRPHLAAILVGHDGGSETYVANKVKACEECGFKSSLIRYESDVTEEELLAKV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  83 RELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPAPLPCTPHGILTLLRRHGVEIKGAEVV 162
Cdd:PRK14185  82 RELNQDDDVDGFIVQLPLPKHISEQKVIEAIDYRKDVDGFHPINVGRMSIGLPCFVSATPNGILELLKRYHIETSGKKCV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 163 VVGRGVTIGRPMPLLLTRRSE--NATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSRNAEG- 239
Cdd:PRK14185 162 VLGRSNIVGKPMAQLMMQKAYpgDCTVTVCHSRSKNLKKECLEADIIIAALGQPEFVKADMVKEGAVVIDVGTTRVPDAt 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 664524730 240 -----KIVGDVHPD-VAEVAAWISPNPGGVGPMTRAQLLVNVVEAAER 281
Cdd:PRK14185 242 rksgfKLTGDVKFDeVAPKCSYITPVPGGVGPMTIVSLMKNTLLAGKK 289

PRK14172

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

4-278

4.62e-81

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 172660 [Multi-domain] Cd Length: 278 Bit Score: 245.85 E-value: 4.62e-81

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   4 QILDGKATAAAIKSELTARVAALKERG-VTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEAVV 82
Cdd:PRK14172   3 QIINGKEVALKIKEEIKNFVEERKENGlSIPKIASILVGNDGGSIYYMNNQEKVANSLGIDFKKIKLDESISEEDLINEI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  83 RELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPAPLPCTPHGILTLLRRHGVEIKGAEVV 162
Cdd:PRK14172  83 EELNKDNNVHGIMLQLPLPKHLDEKKITNKIDANKDIDCLTFISVGKFYKGEKCFLPCTPNSVITLIKSLNIDIEGKEVV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 163 VVGRGVTIGRPMPLLLTrrSENATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSrNAEGKIV 242
Cdd:PRK14172 163 VIGRSNIVGKPVAQLLL--NENATVTICHSKTKNLKEVCKKADILVVAIGRPKFIDEEYVKEGAIVIDVGTS-SVNGKIT 239

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 664524730 243 GDVHPD-VAEVAAWISPNPGGVGPMTRAQLLVNVVEA 278
Cdd:PRK14172 240 GDVNFDkVIDKASYITPVPGGVGSLTTTLLIKNVCEA 276

PLN02897

tetrahydrofolate dehydrogenase/cyclohydrolase, putative

2-281

8.01e-80

tetrahydrofolate dehydrogenase/cyclohydrolase, putative

Pssm-ID: 178485 [Multi-domain] Cd Length: 345 Bit Score: 244.87 E-value: 8.01e-80

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   2 TAQILDGKATAAAIKSELTARVAALKER-GVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEA 80
Cdd:PLN02897  55 KTVVIDGNVIAEEIRTKIASEVRKMKKAvGKVPGLAVVLVGQQRDSQTYVRNKIKACEETGIKSLLAELPEDCTEGQILS 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  81 VVRELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVL--NEPAPLPCTPHGILTLLRRHGVEIKG 158
Cdd:PLN02897 135 ALRKFNEDTSIHGILVQLPLPQHLDESKILNMVRLEKDVDGFHPLNVGNLAMrgREPLFVSCTPKGCVELLIRSGVEIAG 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 159 AEVVVVGRGVTIGRPMPLLLTRrsENATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGV----- 233
Cdd:PLN02897 215 KNAVVIGRSNIVGLPMSLLLQR--HDATVSTVHAFTKDPEQITRKADIVIAAAGIPNLVRGSWLKPGAVVIDVGTtpved 292

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 664524730 234 -SRNAEGKIVGDV-HPDVAEVAAWISPNPGGVGPMTRAQLLVNVVEAAER 281
Cdd:PLN02897 293 sSCEFGYRLVGDVcYEEALGVASAITPVPGGVGPMTITMLLCNTLDAAKR 342

NAD_bind_m-THF_DH_Cyclohyd

cd01080

NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding ...

115-280

2.43e-78

Pssm-ID: 133448 Cd Length: 168 Bit Score: 234.76 E-value: 2.43e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 115 PDKDADGLHPMNLGRLVLNEPAPLPCTPHGILTLLRRHGVEIKGAEVVVVGRGVTIGRPMPLLLTRRseNATVTQCHTGT 194
Cdd:cd01080    1 PEKDVDGLHPVNLGRLALGRPGFIPCTPAGILELLKRYGIDLAGKKVVVVGRSNIVGKPLAALLLNR--NATVTVCHSKT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 195 RDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSR---NAEGKIVGDVHPD-VAEVAAWISPNPGGVGPMTRAQ 270
Cdd:cd01080   79 KNLKEHTKQADIVIVAVGKPGLVKGDMVKPGAVVIDVGINRvpdKSGGKLVGDVDFEsAKEKASAITPVPGGVGPMTVAM 158

                        170
                 ....*....|
gi 664524730 271 LLVNVVEAAE 280
Cdd:cd01080  159 LMKNTVEAAK 168

PRK14170

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

3-281

2.79e-75

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172658 [Multi-domain] Cd Length: 284 Bit Score: 231.50 E-value: 2.79e-75

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   3 AQILDGKATAAAIKSELTARVAALKERGVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEAVV 82
Cdd:PRK14170   2 GEIIDGKKLAKEIQEKVTREVAELVKEGKKPGLAVVLVGDNQASRTYVRNKQKRTEEAGMKSVLIELPENVTEEKLLSVV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  83 RELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPAPLPCTPHGILTLLRRHGVEIKGAEVV 162
Cdd:PRK14170  82 EELNEDKTIHGILVQLPLPEHISEEKVIDTISYDKDVDGFHPVNVGNLFIGKDSFVPCTPAGIIELIKSTGTQIEGKRAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 163 VVGRGVTIGRPMPLLLTrrSENATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSRNAEGKIV 242
Cdd:PRK14170 162 VIGRSNIVGKPVAQLLL--NENATVTIAHSRTKDLPQVAKEADILVVATGLAKFVKKDYIKPGAIVIDVGMDRDENNKLC 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 664524730 243 GDVH-PDVAEVAAWISPNPGGVGPMTRAQLLVNVVEAAER 281
Cdd:PRK14170 240 GDVDfDDVVEEAGFITPVPGGVGPMTITMLLANTLKAAKR 279

PRK14171

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

5-278

7.33e-75

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172659 [Multi-domain] Cd Length: 288 Bit Score: 230.23 E-value: 7.33e-75

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   5 ILDGKATAAAIKSELTARVAALKER-GVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEAVVR 83
Cdd:PRK14171   4 IIDGKALANEILADLKLEIQELKSQtNASPKLAIVLVGDNPASIIYVKNKIKNAHKIGIDTLLVNLSTTIHTNDLISKIN 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  84 ELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLN-EPAPLPCTPHGILTLLRRHGVEIKGAEVV 162
Cdd:PRK14171  84 ELNLDNEISGIIVQLPLPSSIDKNKILSAVSPSKDIDGFHPLNVGYLHSGiSQGFIPCTALGCLAVIKKYEPNLTGKNVV 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 163 VVGRGVTIGRPMPLLLTRrsENATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSRNAEGKIV 242
Cdd:PRK14171 164 IIGRSNIVGKPLSALLLK--ENCSVTICHSKTHNLSSITSKADIVVAAIGSPLKLTAEYFNPESIVIDVGINRISGNKII 241

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 664524730 243 GDVH-PDVAEVAAWISPNPGGVGPMTRAQLLVNVVEA 278
Cdd:PRK14171 242 GDVDfENVKSKVKYITPVPGGIGPMTIAFLLKNTVKA 278

PRK14187

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

5-284

1.04e-74

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172675 [Multi-domain] Cd Length: 294 Bit Score: 230.10 E-value: 1.04e-74

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   5 ILDGKATAAAIKSELTARVAALK-ERGVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEAVVR 83
Cdd:PRK14187   4 IIDGKKIANDITEILATCIDDLKrQHNLFPCLIVILVGDDPASQLYVRNKQRKAEMLGLRSETILLPSTISESSLIEKIN 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  84 ELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPAP--LPCTPHGILTLLRRHGVEIKGAEV 161
Cdd:PRK14187  84 ELNNDDSVHGILVQLPVPNHIDKNLIINTIDPEKDVDGFHNENVGRLFTGQKKNclIPCTPKGCLYLIKTITRNLSGSDA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 162 VVVGRGVTIGRPMPLLLTrrSENATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSRNAEG-- 239
Cdd:PRK14187 164 VVIGRSNIVGKPMACLLL--GENCTVTTVHSATRDLADYCSKADILVAAVGIPNFVKYSWIKKGAIVIDVGINSIEEGgv 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 664524730 240 -KIVGDVH-PDVAEVAAWISPNPGGVGPMTRAQLLVNVVEAAERRAG 284
Cdd:PRK14187 242 kKFVGDVDfAEVKKKASAITPVPGGVGPMTIAFLMVNTVIAACNQKG 288

PRK14194

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

1-283

2.21e-73

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172682 [Multi-domain] Cd Length: 301 Bit Score: 227.04 E-value: 2.21e-73

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   1 MTAQILDGKATAAAIKSELTARVAALKERGVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEA 80
Cdd:PRK14194   2 MSAKLIDGKAAAARVLAQVREDVRTLKAAGIEPALAVILVGNDPASQVYVRNKILRAEEAGIRSLEHRLPADTSQARLLA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  81 VVRELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPAPLPCTPHGILTLLRRHGVEIKGAE 160
Cdd:PRK14194  82 LIAELNADPSVNGILLQLPLPAHIDEARVLQAINPLKDVDGFHSENVGGLSQGRDVLTPCTPSGCLRLLEDTCGDLTGKH 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 161 VVVVGRGVTIGRPMPLLLTRrsENATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSR---NA 237
Cdd:PRK14194 162 AVVIGRSNIVGKPMAALLLQ--AHCSVTVVHSRSTDAKALCRQADIVVAAVGRPRLIDADWLKPGAVVIDVGINRiddDG 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 664524730 238 EGKIVGDVHPDVA-EVAAWISPNPGGVGPMTRAQLLVNVVEAAERRA 283
Cdd:PRK14194 240 RSRLVGDVDFDSAlPVVSAITPVPGGVGPMTIAFLMKNTVTAARLQA 286

PRK14177

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

1-279

1.49e-70

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172665 [Multi-domain] Cd Length: 284 Bit Score: 219.07 E-value: 1.49e-70

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   1 MTAQILDGKATAAAIKSELTARVAALKERGV-TPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIE 79
Cdd:PRK14177   1 MSPILLDGKKLSEKIRNEIRETIEERKTKNKrIPKLATILVGNNPASETYVSMKVKACHKVGMGSEMIRLKEQTTTEELL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  80 AVVRELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPAPLPCTPHGILTLLRRHGVEIKGA 159
Cdd:PRK14177  81 GVIDKLNLDPNVDGILLQHPVPSQIDERAAFDRIALEKDVDGVTTLSFGKLSMGVETYLPCTPYGMVLLLKEYGIDVTGK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 160 EVVVVGRGVTIGRPMPLLLTRRseNATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSRNAeg 239
Cdd:PRK14177 161 NAVVVGRSPILGKPMAMLLTEM--NATVTLCHSKTQNLPSIVRQADIIVGAVGKPEFIKADWISEGAVLLDAGYNPGN-- 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 664524730 240 kiVGDVHPDVA-EVAAWISPNPGGVGPMTRAQLLVNVVEAA 279
Cdd:PRK14177 237 --VGDIEISKAkDKSSFYTPVPGGVGPMTIAVLLLQTLYSF 275

PRK14180

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

5-280

1.64e-70

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 172668 [Multi-domain] Cd Length: 282 Bit Score: 219.13 E-value: 1.64e-70

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730   5 ILDGKATAAAIKSELTARVAALKER-GVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEAVVR 83
Cdd:PRK14180   3 LIDGKSLSKDLKERLATQVQEYKHHtAITPKLVAIIVGNDPASKTYVASKEKACAQVGIDSQVITLPEHTTESELLELID 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  84 ELNEDPDCTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPAPL-PCTPHGILTLLRRHGVEIKGAEVV 162
Cdd:PRK14180  83 QLNNDSSVHAILVQLPLPAHINKNNVIYSIKPEKDVDGFHPTNVGRLQLRDKKCLeSCTPKGIMTMLREYGIKTEGAYAV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 163 VVGRGVTIGRPMPLLLTrrSENATVTQCHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSrNAEGKIV 242
Cdd:PRK14180 163 VVGASNVVGKPVSQLLL--NAKATVTTCHRFTTDLKSHTTKADILIVAVGKPNFITADMVKEGAVVIDVGIN-HVDGKIV 239

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 664524730 243 GDVH-PDVAEVAAWISPNPGGVGPMTRAQLLVNVVEAAE 280
Cdd:PRK14180 240 GDVDfAAVKDKVAAITPVPGGVGPMTITELLYNTFQCAQ 278

PRK14181

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

33-281

3.97e-63

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172669 [Multi-domain] Cd Length: 287 Bit Score: 200.47 E-value: 3.97e-63

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730  33 PGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEAVVRELNEDPDCTGYIVQLPLPRGIDENRILEL 112
Cdd:PRK14181  27 PGLAVVLIGNDPASEVYVGMKVKKATDLGMVSKAHRLPSDATLSDILKLIHRLNNDPNIHGILVQLPLPKHLDAQAILQA 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 113 MDPDKDADGLHPMNLGRLVLNEPAPL-PCTPHGILTLLRRHGVEIKGAEVVVVGRGVTIGRPMPLLLTRR--SENATVTQ 189
Cdd:PRK14181 107 ISPDKDVDGLHPVNMGKLLLGETDGFiPCTPAGIIELLKYYEIPLHGRHVAIVGRSNIVGKPLAALLMQKhpDTNATVTL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 190 CHTGTRDLAAHLRRADIVVAAAGSPHLVRAEDVKPGAAVLDVGVSR----NAEGKI-VGDVH-PDVAEVAAWISPNPGGV 263
Cdd:PRK14181 187 LHSQSENLTEILKTADIIIAAIGVPLFIKEEMIAEKAVIVDVGTSRvpaaNPKGYIlVGDVDfNNVVPKCRAITPVPGGV 266

                        250
                 ....*....|....*...
gi 664524730 264 GPMTRAQLLVNVVEAAER 281
Cdd:PRK14181 267 GPMTVAMLMRNTWESYLR 284

THF_DHG_CYH

pfam00763

Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain;

6-120

1.04e-58

Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain;

Pssm-ID: 459930 [Multi-domain] Cd Length: 115 Bit Score: 182.99 E-value: 1.04e-58

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730    6 LDGKATAAAIKSELTARVAALKERGVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEAVVREL 85
Cdd:pfam00763   1 IDGKAIAKKIREELKEEVAALKAGGRKPGLAVILVGDDPASQVYVRNKKKACEEVGIESELIRLPEDTTEEELLALIDKL 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 664524730   86 NEDPDCTGYIVQLPLPRGIDENRILELMDPDKDAD 120
Cdd:pfam00763  81 NADPSVHGILVQLPLPKHIDEEKVLEAIDPEKDVD 115

NAD_bind_m-THF_DH_Cyclohyd_like

cd05212

NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and ...

138-280

2.35e-24

NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NAD(P) binding domains of methylene-tetrahydrofolate dehydrogenase (m-THF DH) and m-THF DH/cyclohydrolase bifunctional enzymes (m-THF DH/cyclohydrolase). M-THF is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. In addition, most DHs also have an associated cyclohydrolase activity which catalyzes its hydrolysis to N10-formyltetrahydrofolate. m-THF DH is typically found as part of a multifunctional protein in eukaryotes. NADP-dependent m-THF DH in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, mono-functional DH, as well as bifunctional DH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express a monofunctional DH. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.

Pssm-ID: 133451 Cd Length: 140 Bit Score: 95.27 E-value: 2.35e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 138 LPCTPHGI-------LTLLRRHGVEIKGAEVVVVGRGVTIGRPMPLLLTRRseNATVTQCHTGTRDLAAHLRRADIVVAA 210
Cdd:cd05212    1 GPCTPLFVspvakavKELLNKEGVRLDGKKVLVVGRSGIVGAPLQCLLQRD--GATVYSCDWKTIQLQSKVHDADVVVVG 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 211 AGSPHLVRAEDVKPGAAVLDVGVSRNAegkivGDvhpDVAEVAAWISPNPGGVGPMTRAQLLVNVVEAAE 280
Cdd:cd05212   79 SPKPEKVPTEWIKPGATVINCSPTKLS-----GD---DVKESASLYVPMTGGVGKLTVAMRMQNMVRSVR 140

NAD_bind_m-THF_DH

cd01079

NAD binding domain of methylene-tetrahydrofolate dehydrogenase; The NAD-binding domain of ...

115-276

6.79e-11

NAD binding domain of methylene-tetrahydrofolate dehydrogenase; The NAD-binding domain of methylene-tetrahydrofolate dehydrogenase (m-THF DH). M-THF is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. M-THF DH is a component of an unusual monofunctional enzyme; in eukaryotes, m-THF DH is typically found as part of a multifunctional protein. NADP-dependent m-THF DHs in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, monofunctional DH, as well as bifunctional DH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express an monofunctional DH. This family contains only the monofunctional DHs from S. cerevisiae and certain bacteria. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.

Pssm-ID: 133447 [Multi-domain] Cd Length: 197 Bit Score: 60.13 E-value: 6.79e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 115 PDKDADGLHPMNLGRLVLNE---------PAPLPCTPHGILTLLRRHGV---------EIKGAEVVVVGRGVTIGRPMPL 176
Cdd:cd01079    1 PHKDVEGLSHKYIFNLYHNIrfldpenrkKSILPCTPLAIVKILEFLGIynkilpygnRLYGKTITIINRSEVVGRPLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 177 LLTrrSENATV-------TQCHT---GTRDLAAHLRR-----------ADIVVAAAGSPHL-VRAEDVKPGAAVLDVGVS 234
Cdd:cd01079   81 LLA--NDGARVysvdingIQVFTrgeSIRHEKHHVTDeeamtldclsqSDVVITGVPSPNYkVPTELLKDGAICINFASI 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 664524730 235 RNAEgkivgdvhPDVAEVAAWISPNpggVGPMTRAQLLVNVV 276
Cdd:cd01079  159 KNFE--------PSVKEKASIYVPS---IGKVTIAMLLRNLL 189

COG5322

Predicted amino acid dehydrogenase [General function prediction only];

149-249

5.30e-09

Predicted amino acid dehydrogenase [General function prediction only];

Pssm-ID: 444114 [Multi-domain] Cd Length: 362 Bit Score: 56.39 E-value: 5.30e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664524730 149 LRRHGVEIKGAEVVVVGRGVTIGRPMPLLLTRRSENATVTQCHTG-------------------TRDLAAHLRRADIVVA 209
Cdd:COG5322  142 AERMGIDLKKATVAVVGATGSIGSVCARLLAREVKRLTLVARNLErleelaeeilrnpggkvtiTTDIDEALREADIVVT 221

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 664524730 210 AAGSPH-LVRAEDVKPGAAVLDVGVSRNAEGKiVGDVHPDV 249
Cdd:COG5322  222 VTSAVGaIIDPEDLKPGAVVCDVARPRDVSRR-VAEKRPDV 261

HemA

COG0373

Glutamyl-tRNA reductase [Coenzyme transport and metabolism]; Glutamyl-tRNA reductase is part ...

196-252

4.26e-04

Glutamyl-tRNA reductase [Coenzyme transport and metabolism]; Glutamyl-tRNA reductase is part of the Pathway/BioSystem: Heme biosynthesis

Pssm-ID: 440142 [Multi-domain] Cd Length: 425 Bit Score: 41.25 E-value: 4.26e-04

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 664524730 196 DLAAHLRRADIVVAAAGSPH-LVRAEDVKPGAA--------VLDVGVSRnaegkivgDVHPDVAEV 252
Cdd:COG0373  235 ELPEALAEADIVISSTGAPHpVITKEMVERALKkrrhrplfLIDLAVPR--------DIEPEVGEL 292

hemA

PRK00045

glutamyl-tRNA reductase; Reviewed

196-252

5.53e-04

glutamyl-tRNA reductase; Reviewed

Pssm-ID: 234592 [Multi-domain] Cd Length: 423 Bit Score: 40.94 E-value: 5.53e-04

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 664524730 196 DLAAHLRRADIVVAAAGSPHLV-RAEDVKPGAA--------VLDVGVSRnaegkivgDVHPDVAEV 252
Cdd:PRK00045 235 ELPEALAEADIVISSTGAPHPIiGKGMVERALKarrhrpllLVDLAVPR--------DIEPEVGEL 292

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01