|
Name |
Accession |
Description |
Interval |
E-value |
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
1-861 |
0e+00 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 1616.66 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 1 MDEQYNPREVEQTARTFWETNETFKVKEEPGKPKYYCLSMFPYPSGKLHMGHVRNYTIGDVISRYQRMQGKNVMQPMGWD 80
Cdd:COG0495 1 MQERYNPKEIEKKWQKYWEENGTFKADEDSSKPKYYVLDMFPYPSGRLHMGHVRNYTIGDVVARYKRMQGYNVLHPMGWD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 81 AFGLPAENAAIANKSAPAKWTRSNIDYMKNQLKQLGFGYDWSRELATCDPEYYRWEQWFFARLYEKGLVYKKMSTVNWDP 160
Cdd:COG0495 81 AFGLPAENAAIKNGVHPAEWTYENIANMRRQLKRLGLSYDWSREIATCDPEYYKWTQWIFLQLYEKGLAYRKEAPVNWCP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 161 VDQTVLANEQVVDGRGWRSGALVEQKKIPQWFIRITDYAEELLNDLEDMEGWPEQVKTMQRNWIGKSVGTELTFPLKEQE 240
Cdd:COG0495 161 VDQTVLANEQVIDGRCWRCGAPVEKKELPQWFLKITDYADELLDDLDKLDGWPEKVKTMQRNWIGRSEGAEVDFPVEGSD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 241 GGLTVYTTRPDTLMGVSYMAVAAEHPLAK--AAAERHRDVAEFVDQCRNSKVAEAELATMEKKGIDTGFKAIHPLTQEEI 318
Cdd:COG0495 241 EKITVFTTRPDTLFGATFMVLAPEHPLVKelATPEQNAAVAAFIEEAKKKSEIERTSETKEKTGVFTGLYAINPLTGEKI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 319 PVWVANFVLTDYGTGALMAVPGHDERDHEFAVKYKLPIKQVIAPNDSRDIDIQEQAFTEKGVLVSSGKYSGLTSEEAFEE 398
Cdd:COG0495 321 PIWIADYVLMDYGTGAVMAVPAHDQRDFEFAKKYGLPIKQVIAPEDGDDPDILEEAYTGDGVLINSGEFDGLDSEEAKEA 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 399 IADYLEAQGIGKRTVNYRLRDWGVSRQRYWGAPIPMMTLEDGTEMPVPDDQLPVRLPEDVEMDGV-QSPIKADPEWCKTE 477
Cdd:COG0495 401 IIEWLEEKGLGKRKVNYRLRDWLISRQRYWGEPIPIIHCEDCGVVPVPEDQLPVELPEDVDFDPTgGSPLARAPEWVNVT 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 478 --YNGQPATLETDTFDTFMESSWYYARFCSPNYDKGMLDPAAANYWLPVDQYIGGIEHAILHLLYARFFHKLLRDVGLVN 555
Cdd:COG0495 481 cpKCGGPARRETDTMDTFVDSSWYYLRYTDPHNDEAPFDPEAANYWLPVDQYIGGIEHAILHLLYARFFTKVLRDLGLVS 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 556 SSEPFKRLLTQGMVLAetyyrneanggktwynpadvtVERDGkgqvvravlksdgepVEIGGVTKMSKSKNNGIDPQAII 635
Cdd:COG0495 561 FDEPFKRLLTQGMVLE---------------------VGKDG---------------VVIGGIEKMSKSKGNVVDPDEII 604
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 636 DQHGADTVRLFMMFAAPPEQSLEWSDSGVEGAHRFLKRLWRMVNEHTaggEAPAVDPASLNGAQKDLRRKTHETIAKVSD 715
Cdd:COG0495 605 EKYGADTLRLFEMFAGPPERDLEWSDSGVEGAYRFLNRVWRLVVDEA---EALKLDVADLSEADKELRRALHKTIKKVTE 681
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 716 DISrRLTFNTAIAAVMELLNEVGRLSDDEPQTRAVRQEALDTAVLVLSPIVPHICHNLWQALGHSDTVVDASWPVADESA 795
Cdd:COG0495 682 DIE-RLRFNTAIAALMELVNALYKAKDSGEADRAVLREALETLVLLLAPFAPHIAEELWERLGHEGSVADAPWPEADEAA 760
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665842076 796 MVRSEIEVVLQVNGKVRAKENVPADIGKTDLEKLALENENVMRFTDGKTVRKVIVVPGKLVNVVAN 861
Cdd:COG0495 761 LVEDEVTIVVQVNGKVRGKIEVPADASKEELEAAALADEKVQKFLEGKTIRKVIVVPGKLVNIVVK 826
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
5-861 |
0e+00 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 1303.96 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 5 YNPREVEQTARTFWETNETFKVKEEPGKPKYYCLSMFPYPSGKLHMGHVRNYTIGDVISRYQRMQGKNVMQPMGWDAFGL 84
Cdd:TIGR00396 1 YNHIEIEEKWQQKWDENKTFKVTDDSSKPKYYILSMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 85 PAENAAIANKSAPAKWTRSNIDYMKNQLKQLGFGYDWSRELATCDPEYYRWEQWFFARLYEKGLVYKKMSTVNWDPVDQT 164
Cdd:TIGR00396 81 PAENAAIKRGIHPAKWTYENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQWIFLELFEKGLAYVKEADVNWCPNDGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 165 VLANEQVV-DGRGWRSGALVEQKKIPQWFIRITDYAEELLNDLEDMEGWPEQVKTMQRNWIGKSVGTELTFPLKEQEGGL 243
Cdd:TIGR00396 161 VLANEQVDsDGRSWRGDTPVEKKELKQWFLKITAYAEELLNDLEELDHWPESVKEMQRNWIGKSEGVEITFKIADHDEKI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 244 TVYTTRPDTLMGVSYMAVAAEHPLAKAAAERHRDVAEFVDQCRNSKVAEAELATMEKKGIDTGFKAIHPLTQEEIPVWVA 323
Cdd:TIGR00396 241 TVFTTRPDTIFGVTYLALAPEHPLVEKAAENNPKVAAFIKKILNKTVAERTKATKEKKGVDTGIKAIHPLTGEKIPIWVA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 324 NFVLTDYGTGALMAVPGHDERDHEFAVKYKLPIKQVIAPNDSRdiDIQEQAFTEKGVLVSSGKYSGLTSEEAFEEIADYL 403
Cdd:TIGR00396 321 NYVLMEYGTGAVMGVPAHDERDFEFAQKYGLPIKPVIDPAEKD--LSLTAAYTEDGVLVNSGEFNGLNSSEARNAIIDML 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 404 EAQGIGKRTVNYRLRDWGVSRQRYWGAPIPMMTLEDGTEMPVPDDQLPVRLPEDVEMDGV-QSPIKADPEWCKTEYN--G 480
Cdd:TIGR00396 399 EKEGKGKRKVNYRLRDWGFSRQRYWGEPIPIIHCEDGGVVPVPEEDLPVILPEDVVYDGDgGSPLSRIPEWVNVTCPscG 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 481 QPATLETDTFDTFMESSWYYARFCSPNYDKGMLDPAAANYWLPVDQYIGGIEHAILHLLYARFFHKLLRDVGLVNSSEPF 560
Cdd:TIGR00396 479 KPALRETDTMDTFAGSSWYYLRYLDPKNTDGPFDKEKAEYWLPVDLYIGGIEHAILHLLYARFFHKFLRDIGYVNTKEPF 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 561 KRLLTQGMVLAETYYRNeangGKTwynPADVTVERDGKGqvvraVLKSDGEPVEIGGvTKMSKSKNNGIDPQAIIDQHGA 640
Cdd:TIGR00396 559 KKLINQGMVLGFYYPPN----GKV---PADVLTERDEKG-----KDKAGGELVYVGY-EKMSKSKGNGIDPQEIVESYGA 625
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 641 DTVRLFMMFAAPPEQSLEWSDSGVEGAHRFLKRLWRMVNEHTAGGEAPAVDPASLNGAQKDLRRKTHETIAKVSDDISRR 720
Cdd:TIGR00396 626 DALRLFIMFMGPIAASLEWNESGLEGARRFLDRVWNLVYEITGELDAASLTVTALEEAQKELRRDVHKFLKKVTEDLEKR 705
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 721 LTFNTAIAAVMELLNEVGRLSDDepqtrAVRQEALDTAVLVLSPIVPHICHNLWQALGHSDTVVD-ASWPVADESAMVRS 799
Cdd:TIGR00396 706 ESFNTAISAMMELLNKLYKAKKE-----ALMLEYLKGFVTVLSPFAPHLAEELWEKLGSEPFIIDnAKWPVVDETALVED 780
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665842076 800 EIEVVLQVNGKVRAKENVPADIGKTDLEKLALENENVMRFTDGKTVRKVIVVPGKLVNVVAN 861
Cdd:TIGR00396 781 KTLIVVQVNGKFRAKITVPKDADEEQVEELAKQDPEVKKYLENKTIKKVIYVPGKLVNFVIK 842
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
9-860 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 891.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 9 EVEQTARTFWETNETFKVKEE--PGKPKYYCLSMFPYPSGK-LHMGHVRNYTIGDVISRYQRMQGKNVMQPMGWDAFGLP 85
Cdd:PLN02563 84 EIEPKWQRYWEENRTFRTPDDvdTSKPKFYVLDMFPYPSGAgLHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLP 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 86 AENAAIANKSAPAKWTRSNIDYMKNQLKQLGFGYDWSRELATCDPEYYRWEQWFFARLYEKGLVYKKMSTVNWDPVDQTV 165
Cdd:PLN02563 164 AEQYAIETGTHPKITTLKNIARFRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCPALGTV 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 166 LANEQVVDGRGWRSGALVEQKKIPQWFIRITDYAEELLNDLEDMEgWPEQVKTMQRNWIGKSVGTELTFPLKEQEGG--- 242
Cdd:PLN02563 244 LANEEVVDGLSERGGHPVIRKPMRQWMLKITAYADRLLEDLDDLD-WPESIKEMQRNWIGRSEGAELDFSVLDGEGKerd 322
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 243 --LTVYTTRPDTLMGVSYMAVAAEHPL--AKAAAERHRDVAEFVD-QCRNSKVAEAELATmEKKGIDTGFKAIHPLTQEE 317
Cdd:PLN02563 323 ekITVYTTRPDTLFGATYLVVAPEHPLlsSLTTAEQKEAVEEYVDaASRKSDLERTELQK-EKTGVFTGSYAINPATGEA 401
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 318 IPVWVANFVLTDYGTGALMAVPGHDERDHEFAVKYKLPIKQVIAPNDSRDIDiQEQAFTEKGVLVSSG----KYSGLTSE 393
Cdd:PLN02563 402 IPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKPADGNEDD-AEKAYTGEGVIVNSSssglDINGLSSK 480
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 394 EAFEEIADYLEAQGIGKRTVNYRLRDWGVSRQRYWGAPIPMMTLEDGTEM-PVPDDQLPVRLPedvEMDGVQ------SP 466
Cdd:PLN02563 481 EAAKKVIEWLEETGNGKKKVNYKLRDWLFARQRYWGEPIPVVFLEDSGEPvPVPESDLPLTLP---ELDDFTptgtgePP 557
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 467 IKADPEWCKTEY--NGQPATLETDTFDTFMESSWYYARFCSPNYDKGMLDPAAANYWLPVDQYIGGIEHAILHLLYARFF 544
Cdd:PLN02563 558 LAKAVSWVNTVDpsSGKPARRETNTMPQWAGSCWYYLRFMDPKNSNALVDKEKEKYWMPVDLYVGGAEHAVLHLLYARFW 637
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 545 HKLLRDVGLVNSSEPFKRLLTQGMVLAETYYR--NEANGGKTWYNPADVTV----ERDGKGQVVRA----VLKSDGEPVE 614
Cdd:PLN02563 638 HKVLYDIGVVSTKEPFQCLVNQGMILGEVEYTafKDSDGEYVSADTADRLGelqqEKIPEEKVIKSgdsfVLKDDPSIRL 717
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 615 IGGVTKMSKSKNNGIDPQAIIDQHGADTVRLFMMFAAPPEQSLEWSDSGVEGAHRFLKRLWRMV-NEHTAGGEAPAVDPA 693
Cdd:PLN02563 718 IARAHKMSKSRGNVVNPDDVVSEYGADSLRLYEMFMGPLRDSKTWSTSGVEGVHRFLGRTWRLVvGAPLPDGSFRDGTVV 797
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 694 SLNGAQKDLRRKTHETIAKVSDDISrRLTFNTAIAAVMELLNEVGRLsDDEPqtravrQEALDTAVLVLSPIVPHICHNL 773
Cdd:PLN02563 798 TDEEPSLEQLRLLHKCIAKVTEEIE-STRFNTAISAMMEFTNAAYKW-DKVP------REAIEPFVLLLSPYAPHLAEEL 869
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 774 WQALGHSDTVVDASWPVADESAMVRSEIEVVLQVNGKVRAKENVPADIGKTDLEKLALENENVMRFTDGKTVRKVIVVPG 853
Cdd:PLN02563 870 WFRLGHSNSLAYEPWPEANPSYLVDDTVVLPVQINGKTRGTIEVEEGCSEDDAFALASQDEKLSKYLDGKEIKKRIYVPG 949
|
....*..
gi 665842076 854 KLVNVVA 860
Cdd:PLN02563 950 KILNVIL 956
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
34-659 |
6.93e-116 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 355.02 E-value: 6.93e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 34 KYYCLSMFPYPSGKLHMGHVRNYTIGDVISRYQRMQGKNVMQPMGWDAFGLPAENAAIANKSAPAKWTRSNIDYMKNQLK 113
Cdd:cd00812 1 KFYILVMFPYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGRDPEDWTEYNIKKMKEQLK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 114 QLGFGYDWSRELATCDPEYYRWEQWFFARLYEKGLVYKKMSTVnwdpvdqtvlaneqvvdgrGWRsgalveqKKIPQWFI 193
Cdd:cd00812 81 RMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPV-------------------NWC-------KLLDQWFL 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 194 ritDYAEEllndledmeGWPEQVKTMqrnwigksvgteltfplkeqeggltvyttrpdtlmgvsymavaaehplakaaae 273
Cdd:cd00812 135 ---KYSET---------EWKEKLLKD------------------------------------------------------ 148
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 274 rhrdvaefvdqcrnskvaeaeLATMEkkgidtgfkaihpltqeeipvwvanfvltdygtgalmavpghderdhefavkyk 353
Cdd:cd00812 149 ---------------------LEKLD------------------------------------------------------ 153
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 354 lpikqvIAPNDSRDIdiqeqaftekgvlvssgkysgltseeafeeiadyleaqgigkrtvnyrLRDW-GVSRQRYWGAPI 432
Cdd:cd00812 154 ------GWPEEVRAM------------------------------------------------QENWiGCSRQRYWGTPI 179
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 433 PMmtledgtempvpddqlpvrlpedvemdgvqspikadpewckteyngqpatleTDTFDTFMESSWYYARFCSPNYDKGM 512
Cdd:cd00812 180 PW----------------------------------------------------TDTMESLSDSTWYYARYTDAHNLEQP 207
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 513 L------DPAAANYWLPVDQYIGGIEHAILHLLYARFFHKLLRDVGLVnSSEPFKRLLTQGMVLAETyyrneanggktwy 586
Cdd:cd00812 208 YegdlefDREEFEYWYPVDIYIGGKEHAPNHLLYSRFNHKALFDEGLV-TDEPPKGLIVQGMVLLEG------------- 273
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665842076 587 npadvtverdgkgqvvravlksdgepveiggvTKMSKSKNNGIDPQAIIDQHGADTVRLFMMFAAPPEQSLEW 659
Cdd:cd00812 274 --------------------------------EKMSKSKGNVVTPDEAIKKYGADAARLYILFAAPPDADFDW 314
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
221-404 |
2.62e-109 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 332.97 E-value: 2.62e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 221 RNWIGKSVGTELTFPLKEQEGGLTVYTTRPDTLMGVSYMAVAAEHPLAKAAAERHRDVAEFVDQCRNSKVAEAELATMEK 300
Cdd:pfam13603 1 RNWIGRSEGAEITFPVEGTDEKIEVFTTRPDTLMGVTFVALAPEHPLVEKLAEKNPEVAAFIEECKNTSEIERTSETKEK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 301 KGIDTGFKAIHPLTQEEIPVWVANFVLTDYGTGALMAVPGHDERDHEFAVKYKLPIKQVIAPNDS-RDIDIQEQAFTEKG 379
Cdd:pfam13603 81 EGVFTGLYAIHPITGEKIPIWIANFVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKPVIQPEDGdLDLDIMTEAYTEEG 160
|
170 180
....*....|....*....|....*
gi 665842076 380 VLVSSGKYSGLTSEEAFEEIADYLE 404
Cdd:pfam13603 161 ILVNSGEFDGLDSEEAKEAIIKKLE 185
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
1-812 |
1.24e-90 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 305.44 E-value: 1.24e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 1 MDEQYNPREVEQTARTFWETNETFKVKEEPGKPKYYCLSMFPYPSGKLHMGHVRNYTIGDVISRYQRMQGKNVMQPMGWD 80
Cdd:TIGR00422 1 MPKDYDPHEVEKKWYKKWEKSGFFKPDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 81 AFGLPAENA--AIANKSAPAK--------------WTRSNIDYMKNQLKQLGFGYDWSRELATCDPEYYRWEQWFFARLY 144
Cdd:TIGR00422 81 HAGIATQVKveKKLGAEGKTKhdlgreefrekiweWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 145 EKGLVYKKMSTVNWDPVDQTVLANEQVVdgrgwrsgalVEQKKIPQWFIRitdyaeellndledmegwpeqvktmqrnwi 224
Cdd:TIGR00422 161 EKGLIYRGEYLVNWDPKLNTAISDIEVE----------YKEVKGKLYYIR------------------------------ 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 225 gksvgteltFPLKEQEGG-LTVYTTRPDTLMGVSYMAVaaeHPlakaAAERHRdvaEFVDQcrnskvaeaelatmekkgi 303
Cdd:TIGR00422 201 ---------YPLANGSKDyLVVATTRPETMFGDTAVAV---HP----EDERYK---HLIGK------------------- 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 304 dtgfKAIHPLTQEEIPVWVANFVLTDYGTGALMAVPGHDERDHEFAVKYKLPIKQVIapndsrdidiqeqafTEKGVLV- 382
Cdd:TIGR00422 243 ----KVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINIL---------------DEDGLLNe 303
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 383 SSGKYSGLTSEEAFEEIADYLEAQGIGKRTVNYR---------------------------------------------- 416
Cdd:TIGR00422 304 NAGKYQGLTRFEARKKIVEDLKEEGLLVKIEPHThnvgtcwrsgtvvepllskqwfvkvekladkaleaaeegeikfvpk 383
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 417 ------------LRDWGVSRQRYWGAPIPMMTLEDGTEMPVPDDQLPVRlpedvemdgvqSPIKADPewcKTEYNGqpat 484
Cdd:TIGR00422 384 rmekrylnwlrnIKDWCISRQLIWGHRIPVWYCKECGEVYVAKEEPLPD-----------DKTNTGP---SVELEQ---- 445
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 485 lETDTFDTFMESS-WYYARFCSPNYDKGMldpaaANYWlPVDQYIGGieHAILHLLYARFFHKLLRDVGLVnssePFKRL 563
Cdd:TIGR00422 446 -DTDVLDTWFSSSlWPFSTLGWPDETKDL-----KKFY-PTDLLVTG--YDIIFFWVARMIFRSLALTGQV----PFKEV 512
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 564 LTQGMVlaetyyrneanggktwynpadvtveRDGKGQvvravlksdgepveiggvtKMSKSKNNGIDPQAIIDQHGADTV 643
Cdd:TIGR00422 513 YIHGLV-------------------------RDEQGR-------------------KMSKSLGNVIDPLDVIEKYGADAL 548
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 644 RLFMMFAAPPEQSLEWSDSGVEGAHRFLKRLW---RMVNEHTAGGEAPAVDPASLNGAQKDLRRKTHETIAKVSDDISRR 720
Cdd:TIGR00422 549 RFTLASLVTPGDDINFDWKRVESARNFLNKLWnasRFVLMNLSDDLELSGGEEKLSLADRWILSKLNRTIKEVRKALDKY 628
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 721 lTFNTAIAAVMELL-NEVG---------RL-SDDEPQTRAVRQEA---LDTAVLVLSPIVPHICHNLWQALGH-SDTVVD 785
Cdd:TIGR00422 629 -RFAEAAKALYEFIwNDFCdwyielvkyRLyNGNEAEKKAARDTLyyvLDKALRLLHPFMPFITEEIWQHFKEgADSIML 707
|
890 900 910
....*....|....*....|....*....|
gi 665842076 786 ASWPVADESAM-VRSE--IEVVLQVNGKVR 812
Cdd:TIGR00422 708 QSYPVVDAEFVdEEAEkaFELLKEIIVSIR 737
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
1-812 |
8.38e-79 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 271.68 E-value: 8.38e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 1 MDEQYNPREVEQTARTFWETNETFKVKEEPGKPKYYCLSMFPYPSGKLHMGHVRNYTIGDVISRYQRMQGKNVMQPMGWD 80
Cdd:PRK13208 6 LPKKYDPEELEEKWQKIWEEEGTYKFDPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQGWD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 81 AFGLPAENAAIANKSAPA-------------KWTRSNIDYMKNQLKQLGFGYDWSRELATCDPEYYRWEQWFFARLYEKG 147
Cdd:PRK13208 86 DNGLPTERKVEKYYGIRKddisreefielcrELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLDLYKKG 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 148 LVYKKMSTVNWDPVDQTVLANeqvvdgrgwrsgALVEQKKIPQWFIRItdyaeellndledmegwpeqvktmqrnwigks 227
Cdd:PRK13208 166 LIYRAEAPVLWCPRCETAIAQ------------AEVEYREREGKLNYI-------------------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 228 vgtelTFPLKEqEGGLTVYTTRPDtLMGvSYMAVAAeHPlakaAAERHRDVAefvdqcrnskvaeaelatmekkgidtGF 307
Cdd:PRK13208 202 -----KFPVED-GEEIEIATTRPE-LLP-ACVAVVV-HP----DDERYKHLV--------------------------GK 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 308 KAIHPLTQEEIPVWVANFVLTDYGTGALMAVPGHDERDHEFAVKYKLPIKQVIapndsrdidiqeqafTEKGVLVS-SGK 386
Cdd:PRK13208 243 TAIVPLFGVEVPILADPLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTRIII---------------DEDGRMTEaAGK 307
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 387 YSGLTSEEAFEEIADYLEAQG-IGK-----RTVN-----------------------------------------YRLR- 418
Cdd:PRK13208 308 LAGLTIEEARKKIVEDLKSGGlLGKqepikHNVKfcercdtpleilvtrqwfikvldlkeellergkeinwypehMRVRl 387
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 419 ---------DWGVSRQRYWGAPIPMMTLEDGTEMPVPDD-QLPVRlpedvemdgvqsPIKADPEWCKTEYNGQPA-TLET 487
Cdd:PRK13208 388 enwieglnwDWCISRQRYFGTPIPVWYCKDCGHPILPDEeDLPVD------------PTKDEPPGYKCPQCGSPGfEGET 455
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 488 DTFDTFMESSwyyarfCSPNYDKG-MLDPAAANYWLPVD---QyiGgieHAILhllyaRF--FHKLLRdVGLVNSSEPFK 561
Cdd:PRK13208 456 DVMDTWATSS------ITPLIVTGwERDEDLFEKVFPMDlrpQ--G---HDII-----RTwlFYTILR-AYLLTGKLPWK 518
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 562 RLLTQGMVLAEtyyrneanggktwynpadvtverDGKgqvvravlksdgepveiggvtKMSKSKNNGIDPQAIIDQHGAD 641
Cdd:PRK13208 519 NIMISGMVLDP-----------------------DGK---------------------KMSKSKGNVVTPEELLEKYGAD 554
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 642 TVRLFMMFAAPPEQS-LEWSDsgVEGAHRFLKRLW---RMVnEHtAGGEAPAVDPASLNGAQKDLRRKTHETIAKVSDDI 717
Cdd:PRK13208 555 AVRYWAASARLGSDTpFDEKQ--VKIGRRLLTKLWnasRFV-LH-FSADPEPDKAEVLEPLDRWILAKLAKVVEKATEAL 630
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 718 sRRLTFNTAIAAVMELLNEV----------GRLSDDEPQ-----TRAVRQEALDTAVLVLSPIVPHICHNLWQALgHSDT 782
Cdd:PRK13208 631 -ENYDFAKALEEIESFFWHVfcddylelvkSRAYGEDEEeeqksARYTLYTVLDTLLRLLAPFLPFITEEVWSWL-YGGS 708
|
890 900 910
....*....|....*....|....*....|...
gi 665842076 783 VVDASWPVADESA---MVRSEIEVVLQVNGKVR 812
Cdd:PRK13208 709 VHRASWPEPDEELideEDEELGELAKEILSAVR 741
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
1-818 |
6.99e-66 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 236.93 E-value: 6.99e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 1 MDEQYNPREVEQTARTFWETNETFKVKEEPGKPkyYCLsMFPYP--SGKLHMGHVRNYTIGDVISRYQRMQGKNVM-QPm 77
Cdd:PRK05729 5 LPKTYDPKEVEAKWYQKWEEKGYFKPDDNSKKP--FSI-VIPPPnvTGSLHMGHALNNTLQDILIRYKRMQGYNTLwLP- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 78 GWDafglpaeNAAIA------------NKSapaK--------------WTRSNIDYMKNQLKQLGFGYDWSRELATCDPE 131
Cdd:PRK05729 81 GTD-------HAGIAtqmvverqlaaeGKS---RhdlgrekflekvweWKEESGGTITNQLRRLGASCDWSRERFTMDEG 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 132 YYRWEQWFFARLYEKGLVYKKMSTVNWDPVDQTVLANEQVvdgrgwrsgalvEQKKIPQ--WFIRitdYaeellndledm 209
Cdd:PRK05729 151 LSKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEV------------EYKEVKGklWHIR---Y----------- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 210 egwpeqvktmqrnwigksvgteltfPLKEQEGGLTVYTTRPDTLMGVSYMAVaaeHPlakaAAERHRDvaeFVdqcrnsk 289
Cdd:PRK05729 205 -------------------------PLADGSDYLVVATTRPETMLGDTAVAV---NP----EDERYKH---LI------- 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 290 vaeaelatmekkgidtGFKAIHPLTQEEIPVwVA-NFVLTDYGTGALMAVPGHDERDHEFAVKYKLPIkqviapndsrdI 368
Cdd:PRK05729 243 ----------------GKTVILPLVGREIPI-IAdEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPM-----------I 294
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 369 DIqeqaFTEKGVLVSS-GKYSGLTSEEAFEEIADYLEAQGI-------------GKRT-------------V-------- 413
Cdd:PRK05729 295 NI----MDEDGTINENpGEYQGLDRFEARKAIVADLEELGLlvkiephthsvghSDRSgvviepylsdqwfVkmkplakp 370
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 414 -------------------NYR-----LRDWGVSRQRYWGAPIPMMTLEDGtEMPVPDDQlpvrlPEDVEmdgvQSPIKA 469
Cdd:PRK05729 371 aleavengeikfvperwekTYFhwmenIQDWCISRQLWWGHRIPAWYDEDG-EVYVGREE-----PEARE----KALLTQ 440
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 470 DPewckteyngqpatletDTFDT-FmeSSWYYArFCS---PNYDKGMldpaaaNYWLPVDQYIGGieHAILHLLYAR--- 542
Cdd:PRK05729 441 DE----------------DVLDTwF--SSALWP-FSTlgwPEKTEDL------KRFYPTSVLVTG--FDIIFFWVARmim 493
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 543 ----FFHKLlrdvglvnssePFKRLLTQGMVlaetyyrneanggktwynpadvtveRDGKGQvvravlksdgepveiggv 618
Cdd:PRK05729 494 mglhFTGQV-----------PFKDVYIHGLV-------------------------RDEQGR------------------ 519
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 619 tKMSKSKNNGIDPQAIIDQHGADTVRLFMMFAAPPEQSLEWSDSGVEGAHRFLKRLW---RMVNEHTAGGEAPAV-DPAS 694
Cdd:PRK05729 520 -KMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDIRFDEERVEGYRNFANKLWnasRFVLMNLEGADVGELpDPEE 598
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 695 LNGAQKDLRRKTHETIAKVSDDISR-RltFNTAIAAVMELL-NEV---------GRLSDDE-PQTRAVRQEALDTAVLVL 762
Cdd:PRK05729 599 LSLADRWILSRLNRTVAEVTEALDKyR--FDEAARALYEFIwNEFcdwylelakPVLQEAAkRATRATLAYVLEQILRLL 676
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665842076 763 SPIVPHICHNLWQALGH---SDTVVDASWPVADESAMVRSE------IEVVLQVNgKVRAKENVP 818
Cdd:PRK05729 677 HPFMPFITEELWQKLAPlgiEESIMLAPWPEADEAIDEAAEaefewlKELITAIR-NIRAEMNIP 740
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
1-819 |
2.43e-63 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 229.55 E-value: 2.43e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 1 MDEQYNPREVEQTARTFWETNETFKVKEEPGKPKYyCLsMFPYP--SGKLHMGHVRNYTIGDVISRYQRMQGKNVM-QPm 77
Cdd:COG0525 3 LPKTYDPKEVEAKWYQYWEENGYFKADPDSDKEPF-TI-VIPPPnvTGSLHMGHALNNTLQDILIRYKRMQGYNTLwQP- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 78 GWDafglpaeNAAIA------------NKSapaK--------------WTRSNIDYMKNQLKQLGFGYDWSRELATCDPE 131
Cdd:COG0525 80 GTD-------HAGIAtqavverqlaeeGKS---RhdlgrekflervweWKEESGGTITNQLRRLGASCDWSRERFTMDEG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 132 YYRWEQWFFARLYEKGLVY--KKMstVNWDPVDQTVLANEQVvdgrgwrsgalvEQKKIPQ--WFIRitdYaeellndle 207
Cdd:COG0525 150 LSKAVREVFVRLYEKGLIYrgKRL--VNWDPKLKTALSDLEV------------EHEEVKGhlWHIR---Y--------- 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 208 dmegwpeqvktmqrnwigksvgteltfPLKEQEGGLTVYTTRPDTLMGVSYMAVaaeHPlakaAAERHRDvaeFVdqcrn 287
Cdd:COG0525 204 ---------------------------PLADGSGYIVVATTRPETMLGDTAVAV---HP----EDERYKH---LI----- 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 288 skvaeaelatmekkgidtGFKAIHPLTQEEIPVwVA-NFVLTDYGTGALMAVPGHDERDHEFAVKYKLPIkqviapndsr 366
Cdd:COG0525 242 ------------------GKTVILPLVGREIPI-IAdEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPM---------- 292
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 367 dIDIqeqaFTEKGVLVSS-GKYSGLTSEEAFEEIADYLEAQGI-------------GKRT-------------VN----- 414
Cdd:COG0525 293 -INI----LDEDGTINENaGKYRGLDRFEARKAIVADLEELGLlvkvephkhsvghSDRSgtviepylsdqwfVKmkpla 367
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 415 ----------------------YR-----LRDWGVSRQRYWGAPIPMMTLEDGTEMpvpddqlpvrlpedVEMDgvqspi 467
Cdd:COG0525 368 kpaieavedgeikfvperwektYFhwmenIRDWCISRQLWWGHRIPAWYCPDGEVY--------------VART------ 427
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 468 kaDPEWCKtEYNGQPATLETDTFDT-FmeSSW------------------YYarfcsPN------YDkgmldpaaanywl 522
Cdd:COG0525 428 --EPEACA-KAGSVNLTQDEDVLDTwF--SSAlwpfstlgwpektedlkyFY-----PTsvlvtgFD------------- 484
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 523 pvdqyiggiehaILhllyarFF---------HKLLRDVglvnssePFKRLLTQGMVlaetyyrneanggktwynpadvtv 593
Cdd:COG0525 485 ------------II------FFwvarmimmgLHFTGEV-------PFKDVYIHGLV------------------------ 515
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 594 eRDGKGQvvravlksdgepveiggvtKMSKSKNNGIDPQAIIDQHGADTVRLFMMFAAPPEQSLEWSDSGVEGAHRFLKR 673
Cdd:COG0525 516 -RDEQGR-------------------KMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDIKFDEERVEGYRNFANK 575
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 674 LW---RMVNEHTAGGEAP-AVDPASLNGAQKDLRRKTHETIAKVSDDISR-RltFNTAIAAVMELL-NEV---------G 738
Cdd:COG0525 576 LWnasRFVLMNLEGFDPGlDPDPEELSLADRWILSRLNKTIAEVTEALEKyR--FDEAAQALYDFVwNEFcdwylelakP 653
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 739 RLSDDEPQ----TRAVRQEALDTAVLVLSPIVPHICHNLWQALG---HSDTVVDASWPVADESAM---VRSEIEVVLQVN 808
Cdd:COG0525 654 RLYGGDEAakreTRATLVYVLEQILRLLHPFMPFITEEIWQKLPprkEGESIMLAPWPEADEELIdeeAEAEFEWLKEVI 733
|
970
....*....|....
gi 665842076 809 GKVR---AKENVPA 819
Cdd:COG0525 734 SAIRnirAEMNIPP 747
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
17-660 |
6.56e-63 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 223.06 E-value: 6.56e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 17 FWETNETFKVKEEPGKPK-YYCLSMFP-YPSGKLHMGHVRNYTIGDVISRYQRMQGKNVMQPMGWDAFGLPAENA----- 89
Cdd:pfam00133 5 FWDEQGYFKPELEKRKGKpSFTIHDGPpNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVvekkl 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 90 AIANKSAPAKWTRSNI------------DYMKNQLKQLGFGYDWSRELATCDPEYYRWEQWFFARLYEKGLVYKKMSTVN 157
Cdd:pfam00133 85 GIKEKKTRHKYGREEFrekcrewkmeyaDEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGKKLVN 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 158 WDPVDQTVLANeqvvdgrgwrsgALVEQKKI--PQWFIRitdyaeellndledmegwpeqvktmqrnwigksvgteltFP 235
Cdd:pfam00133 165 WSPALNTALSN------------LEVEYKDVkgPSIHVA---------------------------------------FP 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 236 LKEQEGG-LTVYTTRPDTLMGVSYMAVAAEHplakaaaerhrdvaEFVDQCRNSKVAEAELATMEKKGIDT--------- 305
Cdd:pfam00133 194 LADDEGAsLVIWTTTPWTLPGNTAVAVNPEF--------------DYVITGEGYILAEALLKSLYKKGTDKkiledfrgk 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 306 ---GFKAIHPLTQEEIPVWVANFVLTDYGTGALMAVPGHDERDHEFAVKYKLPIKQVIAPNDSrdidiqeqaFTEKGvlv 382
Cdd:pfam00133 260 eleGKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEVINPVDDDGT---------FTEEA--- 327
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 383 ssGKYSGLTSEEAFEEIADYLEAQGI----------------GKRTVNYRL----------------------------- 417
Cdd:pfam00133 328 --PDFQGVYRFDARKKIVELLTEKGLllkiepfthsypfcwrSGTPIIPRAtpqwfvrmdeladqaleavekvqfvpksg 405
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 418 -----------RDWGVSRQRYWGAPIPMMTLEDGTEMpVPDDQLpVRLPEDVEMDGVQspIKADPEWCKTEYNGQPATLE 486
Cdd:pfam00133 406 ekryfnwlaniQDWCISRQRWWGHPIPAWVSKDTEEV-VCRGEL-FELVAGRFEEEGS--IKWLHREAKDKLGYGKGTLE 481
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 487 --TDTFDTFMES-SWYYARFCSPNYDKGMLDPAaanywLPVDQYIGGIEhailhLLYARFFHKLLRDVGLVNsSEPFKRL 563
Cdd:pfam00133 482 qdEDVLDTWFSSgSWPFSTLGWPFVNTEEFKKF-----FPADMLLEGSD-----QTRGWFYRMIMLSTALTG-SVPFKNV 550
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 564 LTQGMVlaetyyrneanggktwynpadvtveRDGKGQvvravlksdgepveiggvtKMSKSKNNGIDPQAIIDQHGADTV 643
Cdd:pfam00133 551 LVHGLV-------------------------RDEQGR-------------------KMSKSLGNVIDPLDVIDKYGADAL 586
|
730
....*....|....*..
gi 665842076 644 RLFMMFaAPPEQSLEWS 660
Cdd:pfam00133 587 RLWLAN-SDYGRDINLS 602
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
4-814 |
1.28e-60 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 222.26 E-value: 1.28e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 4 QYNPREVEQTARTFWETNETFK--VKEEPGKPKYYclsmF----PYPSGKLHMGHVRNYTIGDVISRYQRMQGKNV-MQP 76
Cdd:COG0060 15 RANLPKREPEILKFWEENDIYEksREARAGRPKFV----LhdgpPYANGDIHIGHALNKILKDIIVRYKTMRGFDVpYVP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 77 mGWDAFGLPAENAA---------------IAN------KSApAKWtrsnIDYMKNQLKQLGFGYDWSRELATCDPEYYRW 135
Cdd:COG0060 91 -GWDCHGLPIELKVekelgikkkdiekvgIAEfrekcrEYA-LKY----VDEQREDFKRLGVWGDWDNPYLTMDPEYEES 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 136 EQWFFARLYEKGLVYKKMSTVNWDPVDQTVLANeqvvdgrgwrsgALVE--QKKIPQwfirITdyaeellndledmegwp 213
Cdd:COG0060 165 IWWALKKLYEKGLLYKGLKPVPWCPRCGTALAE------------AEVEykDVTSPS----IY----------------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 214 eqVKtmqrnwigksvgteltFPLKEQEGGLT-------VYTTRPDTLmgVSYMAVAAeHP----------------LAKA 270
Cdd:COG0060 212 --VK----------------FPVKDEKALLLledaylvIWTTTPWTL--PANLAVAV-HPdidyvlvevtggerliLAEA 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 271 AAErhrdvaefvDQCRNSKVAEAE-LATMekKGID-TGFKAIHPL-----TQEEIPVWVANFVLTDYGTGAL-MAvPGHD 342
Cdd:COG0060 271 LVE---------AVLKELGIEDYEvLATF--KGAElEGLRYEHPFyyvvgYDRAHPVILGDYVTTEDGTGIVhTA-PGHG 338
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 343 ERDHEFAVKYKLPIkqvIAPndsrdIDiqeqaftEKGVLVSS-GKYSGLTSEEAFEEIADYLEAQG----IGK------- 410
Cdd:COG0060 339 EDDFEVGKKYGLPV---LNP-----VD-------DDGRFTEEaPLFAGLFVKDANPAIIEDLKERGallaREKithsyph 403
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 411 -------------------------------RTVNY-------RL-------RDWGVSRQRYWGAPIPMMTLEDGTEmPV 445
Cdd:COG0060 404 cwrcktpliyratpqwfismdklrdraleaiEKVNWipewgegRFgnmlenrPDWCISRQRYWGVPIPIWVCEDCGE-LH 482
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 446 PDDQLPVRLPEDVEMDGVQSPIKAD------PEWCKTEYNGQPATLETDTFDTFMES--SWYyarfcspnydkGMLDPAA 517
Cdd:COG0060 483 RTEEVIGSVAELLEEEGADAWFELDlhrpflDETLKCPKCGGTMRRVPDVLDVWFDSgsMHF-----------AVLENRE 551
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 518 ANYWlPVDQYIGGI-EHailhllyaR--FFHKLLRDVGLVNSSePFKRLLTQGMVLaetyyrneanggktwynpadvtve 594
Cdd:COG0060 552 ELHF-PADFYLEGSdQT--------RgwFYSSLLTSTALFGRA-PYKNVLTHGFVL------------------------ 597
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 595 rDGKGQvvravlksdgepveiggvtKMSKSKNNGIDPQAIIDQHGADTVRLFMMfAAPPEQSLEWSDSGVEGAHRFLKRL 674
Cdd:COG0060 598 -DEDGR-------------------KMSKSLGNVVDPQEVIDKYGADILRLWVA-SSDYWGDLRFSDEILKEVRDVYRRL 656
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 675 WrmvNEH------TAG--GEAPAVDPASLNgaqkDLRR----KTHETIAKVSDDIsRRLTFNTAIAAVMELLNEVgrLS- 741
Cdd:COG0060 657 R---NTYrfllanLDDfdPAEDAVPYEDLP----ELDRwilsRLNELIKEVTEAY-DNYDFHRAYRALHNFCVED--LSn 726
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 742 --------------DDEPQTRAVRQ---EALDTAVLVLSPIVPHICHNLWQAL--GHSDTVVDASWPVADES-------- 794
Cdd:COG0060 727 wyldiskdrlyteaADSLDRRAAQTtlyEVLETLVRLLAPILPFTAEEIWQNLpgEAEESVHLADWPEVDEElideelea 806
|
970 980
....*....|....*....|..
gi 665842076 795 --AMVRSEIEVVLQVNGKVRAK 814
Cdd:COG0060 807 kwDLVREVRSAVLKALEAARKE 828
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
2-814 |
3.34e-59 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 217.24 E-value: 3.34e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 2 DEQYNPREVEQTARTFWETNETF-KVKEEP-GKPKYYCLSMFPYPSGKLHMGHVRNYTIGDVISRYQRMQGKNVMQPMGW 79
Cdd:TIGR00392 3 PMRGNLSKREEKILAFWQENDIFeKVKKLNkGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKPGW 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 80 DAFGLPAENAAIANKSAPAK-----------------WTRSNIDYMKNQLKQLGFGYDWSRELATCDPEYYRWEQWFFAR 142
Cdd:TIGR00392 83 DTHGLPIEHKVEKKLGISGKkeissleieefrekcreFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLFKE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 143 LYEKGLVYKKMSTVNWDPVDQTVLANeqvvdgrgwrsgALVEQKKipqwfiritDYAEEllndledmegwpeqvktmqrn 222
Cdd:TIGR00392 163 AHEKGLLYRGLKPVYWSPRCRTALAE------------AEVEYKE---------NYKDV--------------------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 223 wigKSVGTELTFPLKEQE--------GGLTVYTTRPDTLMGVSYMAVAAEHPLAKAAAERHRDVAEfvdqcrnskVAEAE 294
Cdd:TIGR00392 201 ---KDPSIYVKFPVKKDKktylkvklSSLLIWTTTPWTLPSNLAIAVHPDFEYALVQDNTKVEYFI---------LAKKL 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 295 LAT-MEKKGID------------TGFKAIHPLTQ------EEIPVWV-ANFVLTDYGTGALMAVPGHDERDHEFAVKYKL 354
Cdd:TIGR00392 269 VEKlYNKAGSDyeiiktfkgsdlEGLEYEHPLYDfvsqlkEGAPVVIgGDHVTTEDGTGIVHTAPGHGEEDYEIGKKYGL 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 355 PI-----------------KQVIAPNDSRDI----DIQEQAFTEKGVLVSSGKYSG--------------LTSEEAF--- 396
Cdd:TIGR00392 349 EVlspvdekgvytegvndfQGRFVKDADKDIikanKIIIEQLKDKGLLLKAEKITHsyphcwrtktpviyRATEQWFikt 428
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 397 EEIADYLEAQgIGKrtVNY-------RL-------RDWGVSRQRYWGAPIPMMTLEDGTEMPVpdDQLPVRLPEDVEMDG 462
Cdd:TIGR00392 429 KDIKDQMLEQ-IKK--VNWvpewgegRFgnwlenrPDWCISRQRYWGIPIPIWYCEDTGEPIV--VGSIEELIELIELKG 503
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 463 VQSPIKADP----EWCKTEY-NGQPATLETDTFDTFMES-SWYYARFCSPNYDKGMLDPAAANYWLP-VDQYIGgiehai 535
Cdd:TIGR00392 504 IDAWFEDLHrdflDKITLKSgDGGEYRRVPDVLDVWFDSgSMPYASIHYPFENEKFKEVFPADFILEgSDQTRG------ 577
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 536 lhllyarFFHKLLRDVGLVNSSEPFKRLLTQGMVLaetyyrneanggktwynpadvtverDGKGQvvravlksdgepvei 615
Cdd:TIGR00392 578 -------WFYSSLAIGTALFGQAPYKNVITHGFTL-------------------------DEKGR--------------- 610
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 616 ggvtKMSKSKNNGIDPQAIIDQHGADTVRLFMMFAAPPEQsLEWSDSGVEGAHRFLKRLWRMV--------NEHTAGGEA 687
Cdd:TIGR00392 611 ----KMSKSLGNVVDPLKVINKYGADILRLYVASSDPWED-LRFSDEILKQVVEKYRKIRWNTyrflltyaNLDKFDPLF 685
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 688 PAVDPASLNGAQKDLRRKTHETIAKVSDDISrRLTFNTAIAAVMELLNEvgRLS--------------DDEPQTRAVRQ- 752
Cdd:TIGR00392 686 NSVAVEKFPEEDRWILSRLNSLVEEVNEALE-KYNFHKVLRALQDFIVE--ELSnwyiriirdrlyceAKDNDKRAAQTt 762
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665842076 753 --EALDTAVLVLSPIVPHICHNLWQALGHSD---TVVDASWPVADES----------AMVRSEIEVVLQVNGKVRAK 814
Cdd:TIGR00392 763 lyYALLTLVRLLAPFLPHTAEEIYQNLPGGEeeeSVHLNLWPEVDEEfidealeanmAIVREIVEAFLALRDAANKK 839
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
48-803 |
1.72e-56 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 209.72 E-value: 1.72e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 48 LHMGHVRNYTIGDVISRYQRMQGKNVMQPMGWDAFGLP----AEnaAIANK----------------------SAPAKWT 101
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPilgiAE--RIARGdpetielykslygipeeelekfKDPEYIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 102 RSNIDYMKNQLKQLGFGYDWSRELATCDPEYYRWEQWFFARLYEKGLVYKKMSTVNWDPVDQTVLANEQVVDGRGwrsga 181
Cdd:PRK12300 79 EYFSEEAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGDHDLLDGEE----- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 182 lveqkkipqwfIRITDYAEELLNDLEDmegwpeqvktmqrnwigksvgteLTFPlkeqeggltVYTTRPDTLMGVSYMAV 261
Cdd:PRK12300 154 -----------PEIVEYTLIKFEESED-----------------------LILP---------AATLRPETIFGVTNLWV 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 262 --AAEHPLAKAAAER---HRDVAE-FVDQCRNSKVAEaelatmEKKGID-TGFKAIHPLTQEEIPVWVANFVLTDYGTGA 334
Cdd:PRK12300 191 npDATYVKAEVDGEKwivSKEAAEkLSFQDRDVEIIE------EIKGSElIGKKVKNPVTGKEVPILPADFVDPDNGTGV 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 335 LMAVPGHDERDHeFAVK------YKLPIKQVI------------APNDSRDIDIQEQA------FTE--------KGVLV 382
Cdd:PRK12300 265 VMSVPAHAPYDY-VALRdlkknkELLDVIEPIplievegygefpAKEVVEKLGIKSQEdpeleeATKevyraefhKGVLK 343
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 383 SS-GKYSGLTSEEAFEEIADYLEAQGIG-------------------------------------KRTV----------- 413
Cdd:PRK12300 344 ENtGEYAGKPVREAREKITKDLIEKGIAdimyefsnrpvycrcgtecvvkvvkdqwfidysdpewKELAhkaldnmeiip 423
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 414 -NYR---------LRDWGVSRQRYWGAPIP------MMTLEDGT-------------EMPVPDDQLPVRLPEDVEMDgvq 464
Cdd:PRK12300 424 eEYRkefentidwLKDRACARRRGLGTRLPwdeewiIESLSDSTiymayytiahkirEYGIKPEQLTPEFFDYVFLG--- 500
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 465 spiKADPEWCKTEYNGQPATLETdtfdtfmesswyyAR--FcspnydkgmldpaaaNYWLPVDQYIGGIEHAILHLLYAR 542
Cdd:PRK12300 501 ---KGDPEEVSKKTGIPKEILEE-------------MReeF---------------LYWYPVDWRHSGKDLIPNHLTFFI 549
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 543 FFHkllrdVGLvnssepF-KRLLTQGMVLaetyyrneaNGgktwynpadvTVERDGKgqvvravlksdgepveiggvtKM 621
Cdd:PRK12300 550 FNH-----VAI------FpEEKWPRGIVV---------NG----------FVLLEGK---------------------KM 578
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 622 SKSKNNGIDPQAIIDQHGADTVRLFMMFAAPPEQSLEWSDSGVEGAHRFLKRLWRMVNEH-TAGGEAPavdpasLNGAQK 700
Cdd:PRK12300 579 SKSKGNVIPLRKAIEEYGADVVRLYLTSSAELLQDADWREKEVESVRRQLERFYELAKELiEIGGEEE------LRFIDK 652
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 701 DLRRKTHETIAKVSDDISR---RLTFNTAIAAVMELLNEVGRLSDDEPqtRAVRQEALDTAVLVLSPIVPHICHNLWQAL 777
Cdd:PRK12300 653 WLLSRLNRIIKETTEAMESfqtRDAVQEAFYELLNDLRWYLRRVGEAN--NKVLREVLEIWIRLLAPFTPHLAEELWHKL 730
|
890 900
....*....|....*....|....*.
gi 665842076 778 GHSDTVVDASWPVADESaMVRSEIEV 803
Cdd:PRK12300 731 GGEGFVSLEKWPEPDES-KIDEEAEL 755
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
659-777 |
1.50e-50 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 173.17 E-value: 1.50e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 659 WSDSGVEGAHRFLKRLWRMVNEHTAGGEAPAvDPASLNGAQKDLRRKTHETIAKVSDDISRRlTFNTAIAAVMELLNEVG 738
Cdd:cd07958 1 WSDSGVEGAYRFLNRVWRLVTELAEALAAPA-AAAELSEEDKELRRKLHKTIKKVTEDIERL-RFNTAIAALMELVNALY 78
|
90 100 110
....*....|....*....|....*....|....*....
gi 665842076 739 RLSDDEPQTRAVRQEALDTAVLVLSPIVPHICHNLWQAL 777
Cdd:cd07958 79 KYKKKDAQHAAVLREALETLVLLLAPFAPHIAEELWEEL 117
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
42-227 |
1.24e-48 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 177.05 E-value: 1.24e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 42 PYPSGKLHMGHVRNYTIGDVISRYQRMQGKNVMQPMGWDAFGLPAEN-----AAIANKSAPA-----------KWTRSNI 105
Cdd:cd00817 10 PNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVvvekkLGIEGKTRHDlgreeflekcwEWKEESG 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 106 DYMKNQLKQLGFGYDWSRELATCDPEYYRWEQWFFARLYEKGLVYKKMSTVNWDPVDQTVLANEQVvdgrGWRSGALVEQ 185
Cdd:cd00817 90 GKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV----CSRSGDVIEP 165
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 665842076 186 KKIPQWFIRITDYAEELLNDLE--DMEGWPEQVKTMQRNWIGKS 227
Cdd:cd00817 166 LLKPQWFVKVKDLAKKALEAVKegDIKFVPERMEKRYENWLENI 209
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
5-853 |
2.80e-48 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 185.97 E-value: 2.80e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 5 YNPREVEQTARTFWETNETFKVKEEP-GKPKYYCLSMFPYPSGKLHMGHVRNYTIGDVISRYQRMQGKNVMQPMGWDAFG 83
Cdd:PRK14900 19 YEHREVEARWYPFWQERGYFHGDEHDrTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 84 LPAENAAIANKSAPAKWTRSNI---DYMK--------------NQLKQLGFGYDWSRELATCDPEYYRWEQWFFARLYEK 146
Cdd:PRK14900 99 IATQMIVEKELKKTEKKSRHDLgreAFLErvwawkeqygsrigEQHKALGASLDWQRERFTMDEGLSRAVREVFVRLHEE 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 147 GLVYKKMSTVNWDPVDQTVLANEQVvDGRGWRSGALveqkkipqWFIRitdyaeellndledmegwpeqvktmqrnwigk 226
Cdd:PRK14900 179 GLIYREKKLINWCPDCRTALSDLEV-EHEEAHQGEL--------WSFA-------------------------------- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 227 svgteltFPLKEQEGGLTVYTTRPDTLMGVSYMAVaaeHPLAkaaaERHRDVaefvdqcrnskvaeaelatmekkgidTG 306
Cdd:PRK14900 218 -------YPLADGSGEIVVATTRPETMLGDTAVAV---HPLD----PRYMAL--------------------------HG 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 307 FKAIHPLTQEEIPVwVANFVLTD--YGTGALMAVPGHDERDHEFAVKYKLPIKQVIAPnDSRdidiqeqaFTEKgvlvsS 384
Cdd:PRK14900 258 KKVRHPITGRTFPI-VADAILVDpkFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIGP-DGR--------MTAE-----A 322
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 385 GKYSGLTSEEAFEEIADYLEAQGIGKRTVNYRL----------------------------------------------- 417
Cdd:PRK14900 323 GPLAGLDRFEARKEVKRLLAEQGLDRGAKPHVLplgrcqrsatilepllsdqwyvrieplarpaieaveqgrtrfipeqw 402
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 418 -----------RDWGVSRQRYWGAPIPMMTLEDGtEMPVPDDQlpvrlpedvemdgvqspikadPEWCKTeYNGQPATLE 486
Cdd:PRK14900 403 tntymawmrniHDWCISRQLWWGHQIPAWYCPDG-HVTVARET---------------------PEACST-CGKAELRQD 459
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 487 TDTFDTFMESS-WYYARFCSPNydkgmlDPAAANYWLPVDQYIGGieHAILHLLYARFFHKLLRDVGLVnssePFKRLLT 565
Cdd:PRK14900 460 EDVLDTWFSSGlWPFSTMGWPE------QTDTLRTFYPTSVMETG--HDIIFFWVARMMMMGLHFMGEV----PFRTVYL 527
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 566 QGMVlaetyyrneanggktwynpadvtveRDGKGQvvravlksdgepveiggvtKMSKSKNNGIDPQAIIDQHGADTVRL 645
Cdd:PRK14900 528 HPMV-------------------------RDEKGQ-------------------KMSKTKGNVIDPLVITEQYGADALRF 563
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 646 FMMFAAPPEQSLEWSDSGVEGAHRFLKRLW---RMVNEHTAGGEAPAVDPASLNGAQKD------LRRKTHETIAKVSDd 716
Cdd:PRK14900 564 TLAALTAQGRDIKLAKERIEGYRAFANKLWnasRFALMNLSGYQERGEDPARLARTPADrwilarLQRAVNETVEALEA- 642
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 717 isrrLTFNTAIAAVMELL-NEV---------GRLSDDEPQ----TRAVRQEALDTAVLVLSPIVPHICHNLWQAL----- 777
Cdd:PRK14900 643 ----FRFNDAANAVYAFVwHELcdwyielakEALASEDPEarrsVQAVLVHCLQTSYRLLHPFMPFITEELWHVLraqvg 718
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 778 --GHSDTVVDASWP---VADESAM-----VRSEIEVVLQVNG------KVRAKENVPADIGKTDLEKLAL----ENENVM 837
Cdd:PRK14900 719 asAWADSVLAAEYPrkgEADEAAEaafrpVLGIIDAVRNIRGemgipwKVKLGAQAPVEIAVADPALRDLlqagELARVH 798
|
970
....*....|....*.
gi 665842076 838 RFTDGKTVRKVIVVPG 853
Cdd:PRK14900 799 RVAGVEGSRLVVAAAT 814
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
34-224 |
4.32e-38 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 144.87 E-value: 4.32e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 34 KYYCLSMFPYPSGKLHMGHVRNYTIGDVISRYQRMQGKNVMQPMGWDAFGLPAENAA-----IANKSAPAKWTRS----- 103
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAerkggRKKKTIWIEEFREdpkef 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 104 ---NIDYMKNQLKQLGFGYDWSRELATCDPEYYRWEQWFFARLYEKGLVYKkmstvnwdpvdqtvlaneqvvdgrgwrsg 180
Cdd:cd00668 81 veeMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYR----------------------------- 131
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 665842076 181 ALVEQKKIPQWFIRITDYAEELLNDLEDMEGWPEQVKTMQRNWI 224
Cdd:cd00668 132 GTHPVRITEQWFFDMPKFKEKLLKALRRGKIVPEHVKNRMEAWL 175
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
17-811 |
1.05e-31 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 133.36 E-value: 1.05e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 17 FWETNETFK--VKEEPGKPkyyclsmF------PYPSGKLHMGHVRNYTIGDVISRYQRMQGKNVMQPMGWDAFGLPAE- 87
Cdd:PLN02843 15 LWEENQVYKrvSDRNNGES-------FtlhdgpPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIEl 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 88 ------NAAIANKSAP-------AKWTRSNIDYMKNQLKQLGFGYDWSRELATCDPEYYRWEQWFFARLYEKGLVYKKMS 154
Cdd:PLN02843 88 kvlqslDQEARKELTPiklrakaAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYRGRK 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 155 TVNWDPVDQTVLANEQVVDGRGWRSGALveqkkipqwfiritdYAEELLNDLedmegwpeqvktmqrnwiGKSVGTELTF 234
Cdd:PLN02843 168 PVHWSPSSRTALAEAELEYPEGHVSKSI---------------YVAFPVVSP------------------SETSPEELEE 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 235 PLkeQEGGLTVYTTRPDTL---MGV------SYMAVAAEHPLAKAAAERHRDVAEFVDQCRNSK-----VAEAELATMEK 300
Cdd:PLN02843 215 FL--PGLSLAIWTTTPWTMpanAAVavndklQYSVVEVQSFSEDESTSGGNKKKRPGNVLKEQQklfliVATDLVPALEA 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 301 K------------GID-TGFKAIHPLTQEEIPVWVA-NFVLTDYGTGALMAVPGHDERDHEFAVKYKLPIkqvIAPNDS- 365
Cdd:PLN02843 293 KwgvklvvlktfpGSDlEGCRYIHPLYNRESPVVIGgDYITTESGTGLVHTAPGHGQEDYITGLKYGLPL---LSPVDDa 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 366 ----------RDIDIQEQ-------AFTEKGVLVSSGKYSG--------------------LTSEEAFEEIA-------D 401
Cdd:PLN02843 370 gkfteeagqfSGLSVLGEgnaavveALDEAGSLLMEEAYGHkypydwrtkkptifrateqwFASVEGFRQAAldaidkvK 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 402 YLEAQGIGKRT--VNYRlRDWGVSRQRYWGAPIPMMTLEDGTEmPVPDDQLpvrlpedveMDGVQSPIK---ADPEWCKT 476
Cdd:PLN02843 450 WIPAQGENRIRamVSGR-SDWCISRQRTWGVPIPVFYHVETKE-PLMNEET---------IAHVKSIVAqkgSDAWWYMD 518
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 477 -------EYNGQPATLE--TDTFDTFMES--SWyyarfcspnydKGMLDPAAANYWlPVDQYIGGIEHailHLLYarFFH 545
Cdd:PLN02843 519 vedllpeKYRDKASDYEkgTDTMDVWFDSgsSW-----------AGVLGSREGLSY-PADLYLEGSDQ---HRGW--FQS 581
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 546 KLLRDVGlVNSSEPFKRLLTQGMVLaetyyrneanggktwynpadvtverDGKGQvvravlksdgepveiggvtKMSKSK 625
Cdd:PLN02843 582 SLLTSVA-TKGKAPYKSVLTHGFVL-------------------------DEKGF-------------------KMSKSL 616
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 626 NNGIDPQAIID---------QHGADTVRLFMM-------FAAPPEQSLEWSDS--GVEGAHRFLkrlwrMVNEHTAGGEA 687
Cdd:PLN02843 617 GNVVDPRLVIEggknqkqepAYGADVLRLWVAsvdytgdVLIGPQILKQMSDIyrKLRGTLRYL-----LGNLHDWKPDN 691
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 688 pAVDPASLNGAQKDLRRKTHETIAKVSDDISrRLTFNTAIA-----AVMELLN---EVG--RL---SDDEPQTRAVrQEA 754
Cdd:PLN02843 692 -AVPYEDLPSIDKYALFQLENVVNEIEESYD-NYQFFKIFQilqrfTIVDLSNfylDVAkdRLyvgGTTSFTRRSC-QTV 768
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665842076 755 LDTAVL----VLSPIVPHICHNLWQALGHSD------TVVDASWPVADESAMVRSEIEV-----VLQVNGKV 811
Cdd:PLN02843 769 LAAHLLsllrAIAPILPHLAEDAWQNLPFQEdgsaaeSVFEAGWPTPNEEWLSFPAEDVdfwslLLEVRDEV 840
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
1-433 |
1.79e-31 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 132.82 E-value: 1.79e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 1 MDEQYNPREVEQTARTFWETNETFKVKEEPGKP----KYYCLSMFPYPSGKLHMGHVRNYTIGDVISRYQRMQGKNVMqp 76
Cdd:PTZ00419 24 MAASYDPKEVESGWYEWWEKSGFFKPAEDAKSLnsgkKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETL-- 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 77 mgWdafgLP-AENAAIANKSAPAK------------------------WTRSNIDYMKNQLKQLGFGYDWSRELATCDPE 131
Cdd:PTZ00419 102 --W----VPgTDHAGIATQVVVEKklmkeenktrhdlgreeflkkvweWKDKHGNNICNQLRRLGSSLDWSREVFTMDEQ 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 132 YYRWEQWFFARLYEKGLVYKKMSTVNWDPVDQTVLANEQVVdgrgwrsgaLVEQKKiPQwFIRITDYAeellndledmeg 211
Cdd:PTZ00419 176 RSKAVKEAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVE---------FEEIEK-PT-KITIPGYD------------ 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 212 wpeqvKTMQRNWIgksvgTELTFPLKE-QEGGLTVYTTRPDTLMGVSYMAVaaeHPLakaaAERHRDVaefvdqcrnskv 290
Cdd:PTZ00419 233 -----KKVEVGVL-----WHFAYPLEDsGQEEIVVATTRIETMLGDVAVAV---HPK----DERYKKL------------ 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 291 aeaelatmekkgidTGFKAIHPLTQEEIPVWVANFVLTD--YGTGALMAVPGHDERDHEFAVKYKLPIkqviapndsrdI 368
Cdd:PTZ00419 284 --------------HGKELIHPFIPDRKIPIIADDELVDmeFGTGAVKITPAHDPNDYEIAKRHNLPF-----------I 338
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 369 DIqeqaFTEKGVL-VSSGKYSGLTSEEAFEEIADYLEAQG------------------------------------IGKR 411
Cdd:PTZ00419 339 NI----FTLDGKInENGGEFAGMHRFDCRRKIEEELKEMGllrdkvpnpmrlprcsrsgdivepmlipqwyvnckdMAKR 414
|
490 500 510 520
....*....|....*....|....*....|....*....|....
gi 665842076 412 TVN------------------YR----LRDWGVSRQRYWGAPIP 433
Cdd:PTZ00419 415 AVEavrngelkiipsshenvwYHwlenIQDWCISRQLWWGHRIP 458
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
34-224 |
4.45e-28 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 115.71 E-value: 4.45e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 34 KYYCLSMFPYPSGKLHMGHVRNYTIGDVISRYQRMQGKNVMQPMGWDAFGLPAENAAIANKSAPAKWTRSNIDYMKNQLK 113
Cdd:cd00814 1 KVLITTALPYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEEGVTPQELCDKYHEIFKDLFK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 114 QLGFGYD-WSRelaTCDPEYYRWEQWFFARLYEKGLVYKKMSTVNWDPVDQTVLAneqvvdgrgwrsgalvEQKKIPQWF 192
Cdd:cd00814 81 WLNISFDyFIR---TTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFLP----------------EWREEEHYF 141
|
170 180 190
....*....|....*....|....*....|....
gi 665842076 193 IRITDYAEELLNDLEDMEG--WPEQVKTMQRNWI 224
Cdd:cd00814 142 FRLSKFQDRLLEWLEKNPDfiWPENARNEVLSWL 175
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
1-442 |
2.65e-27 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 119.62 E-value: 2.65e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 1 MDEQYNPREVEQTARTFWETNETFKVKEEPGKPKYYCLSMFPYPSGKLHMGHVRNYTIGDVISRYQRMQGKNVMQPMGWD 80
Cdd:PLN02381 96 MAKQYSPSAVEKSWYAWWEKSGYFGADAKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVD 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 81 AFGLpAENAAIANK------------------SAPAKWTRSNIDYMKNQLKQLGFGYDWSRELATCDPEYYRWEQWFFAR 142
Cdd:PLN02381 176 HAGI-ATQVVVEKKlmrerhltrhdigreefvSEVWKWKDEYGGTILNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVR 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 143 LYEKGLVYKKMSTVNWDPVDQTVLANEQVvdgrgwrsgalveqkkipqwfiritDYAEELLNDLEDMEGWPEQVKTmqrn 222
Cdd:PLN02381 255 LYKEGLIYRDIRLVNWDCTLRTAISDVEV-------------------------DYIDIKERTLLKVPGYDKPVEF---- 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 223 wigkSVGTELTFPLKEQEGGLTVYTTRPDTLMGVSYMAVaaeHPLAKAAAERHrdvaefvdqcrnskvaeaelatmekkg 302
Cdd:PLN02381 306 ----GVLTSFAYPLEGGLGEIVVATTRIETMLGDTAIAI---HPDDERYKHLH--------------------------- 351
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 303 idtGFKAIHPLTQEEIPVwVANFVLTD--YGTGALMAVPGHDERDHEFAVKYKLPIkqviapndsrdIDIqeqaFTEKGV 380
Cdd:PLN02381 352 ---GKFAVHPFNGRKLPI-ICDAILVDpnFGTGAVKITPAHDPNDFEVGKRHNLEF-----------INI----FTDDGK 412
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 381 LVSSG--KYSGLTSEEAFEEIADYLEAQGIGKRTVN-------------------------------------------- 414
Cdd:PLN02381 413 INSNGgsEFAGMPRFAAREAVIEALQKKGLYRGAKNnemrlglcsrtndvvepmikpqwfvncssmakqaldaaidgenk 492
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 665842076 415 -------------YR----LRDWGVSRQRYWGAPIPM--MTLEDGTE 442
Cdd:PLN02381 493 klefipkqylaewKRwlenIRDWCISRQLWWGHRIPAwyVTLEDDQL 539
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
33-224 |
9.29e-26 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 112.51 E-value: 9.29e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 33 PKYYCLSMFPYPSGKLHMGHVRNYTIGDVISRYQRMQGKNVMQPMGWDAFGLPAENAAIANKSAPAKWTRSNIDYMKNQL 112
Cdd:COG0143 1 KKFLVTTAIPYANGPPHIGHLYTYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAAEKEGITPQELVDRIHAEFKELF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 113 KQLGFGYD-WSRelaTCDPEYYRWEQWFFARLYEKGLVYKKMSTVNWDPVDQT--------------------------- 164
Cdd:COG0143 81 EKLGISFDnFIR---TTSPEHKELVQEIFQRLYDNGDIYKGEYEGWYCPECERflpdryvegtcpkcgaedaygdqcenc 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665842076 165 --VLANEQVVDGRGWRSGALVEQKKIPQWFIRITDYAEELLNDLEDMEGWPEQVKTMQRNWI 224
Cdd:COG0143 158 gaTLEPTELINPRSAISGAPPELREEEHYFFRLSKYQDRLLEWIEENPDIQPEVRNEVLSWL 219
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
42-224 |
1.21e-25 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 108.86 E-value: 1.21e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 42 PYPSGKLHMGHVRNYTIGDVISRYQRMQGKNVMQPMGWDAFGLPAENAA-----IANKSAPAKWT------------RSN 104
Cdd:cd00818 10 PYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVekelgISGKKDIEKMGiaefnakcrefaLRY 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 105 IDYMKNQLKQLGFGYDWSRELATCDPEYYRWEQWFFARLYEKGLVYKKMSTVNWdPvdqtvlaneqvvdgrgwrsgalVE 184
Cdd:cd00818 90 VDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW-P----------------------LI 146
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 665842076 185 QKKIPQWFIRITDYAEELLNDLEDMEGWPEQVKTMQRNWI 224
Cdd:cd00818 147 YRATPQWFIRVTKIKDRLLEANDKVNWIPEWVKNRFGNWL 186
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
11-789 |
3.47e-25 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 112.34 E-value: 3.47e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 11 EQTARTFWETNETFKVKEEPGKPKYYCLSMFPYPSGKLHMGHVRNYTIGDVISRYQRMQGKNVMQPMGWDAFG------- 83
Cdd:PLN02943 66 EERIYNWWESQGYFKPNFDRGGDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGiatqlvv 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 84 ---LPAENAAIANKSAPA------KWTRSNIDYMKNQLKQLGFGYDWSRELATCDPEYYRWEQWFFARLYEKGLVYKKMS 154
Cdd:PLN02943 146 ekmLASEGIKRTDLGRDEftkrvwEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQGSY 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 155 TVNWDPVDQTVLANEQVvdgrgwrsgalveqkkipqwfiritDYAEEllndledmegwPEQVKTMQRNWIGKSvgteltf 234
Cdd:PLN02943 226 MVNWSPNLQTAVSDLEV-------------------------EYSEE-----------PGTLYYIKYRVAGGS------- 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 235 plkeqEGGLTVYTTRPDTLMGVSYMAVAAEHplakaaaERHrdvAEFVdqcrnskvaeaelatmekkgidtGFKAIHPLT 314
Cdd:PLN02943 263 -----EDFLTIATTRPETLFGDVAIAVNPED-------DRY---SKYI-----------------------GKMAIVPMT 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 315 -QEEIPVWVANFVLTDYGTGALMAVPGHDERDHEFAVKYKLPIKQVIapndSRDIDIQEQA--------------FTEKG 379
Cdd:PLN02943 305 yGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVM----NKDGTLNEVAglywfeareklwsdLEETG 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 380 VLVSSGKYS--------------GLTSEEAF---EEIAD-YLEAQGIGKRTV---------NYRL---RDWGVSRQRYWG 429
Cdd:PLN02943 381 LAVKKEPHTlrvprsqrggeviePLVSKQWFvtmEPLAEkALKAVENGELTIiperfekiyNHWLsniKDWCISRQLWWG 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 430 APIPMMTLEdGTEmpVPDDQLPVRLPEDVeMDGVQSPIKADPEwckteyngqpATLETDTFDTFMESS-WYYARFCSPny 508
Cdd:PLN02943 461 HRIPVWYIV-GKD--CEEDYIVARSAEEA-LEKAREKYGKDVE----------IYQDPDVLDTWFSSAlWPFSTLGWP-- 524
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 509 dkgmlDPAAANY--WLPVDQYIGGieHAILHLLYARFFHKLLRDVGLVnssePFKRLLTQGMVlaetyyrneanggktwy 586
Cdd:PLN02943 525 -----DVSAEDFkkFYPTTVLETG--HDILFFWVARMVMMGIEFTGTV----PFSYVYLHGLI----------------- 576
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 587 npadvtveRDGKGQvvravlksdgepveiggvtKMSKSKNNGIDPQAIIDQHGADTVRlFMMFAAPPEQSLEWSDSGVEG 666
Cdd:PLN02943 577 --------RDSQGR-------------------KMSKTLGNVIDPLDTIKEFGTDALR-FTLALGTAGQDLNLSTERLTS 628
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 667 AHRFLKRL-------------------WRMVNEHTAGGEAPAvdpASLNGAQKDLRRKTHETIAKVSDDISrRLTFNTAI 727
Cdd:PLN02943 629 NKAFTNKLwnagkfvlqnlpsqsdtsaWEHILACKFDKEESL---LSLPLPECWVVSKLHELIDSVTTSYD-KYFFGDVG 704
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665842076 728 AAVMELL----------NEVGRLSDDEPQTRAVRQEAL-----DTAVLVLSPIVPHICHNLWQALGH-SDTVVDASWP 789
Cdd:PLN02943 705 REIYDFFwsdfadwyieASKTRLYHSGDNSALSRAQAVllyvfENILKLLHPFMPFVTEELWQALPYrKEALIVSPWP 782
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
7-829 |
8.33e-25 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 111.36 E-value: 8.33e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 7 PREVEQTARtFWETNETFK--VKEEPGKPKYYCLSMFPYPSGKLHMGHVRNYTIGDVISRYQRMQGKNVMQPMGWDAFGL 84
Cdd:PLN02882 11 PKQEEKILS-LWSEIDAFKtqLKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHGL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 85 PAENA-----AIANKSAPAKW-------------TRSNIDYMKNqLKQLGFGYDWSRELATCDPEYYRWEQWFFARLYEK 146
Cdd:PLN02882 90 PVEYEidkklGIKRRDDVLKMgidkyneecrsivTRYSKEWEKT-VTRTGRWIDFENDYKTMDPKFMESVWWVFKQLFEK 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 147 GLVYKKMSTVNWDPVDQTVLANEQvvdgrgwrsgALVEQKKIPqwfiritdyaeellnDLEDMegwpeqvktmqrnwigk 226
Cdd:PLN02882 169 GLVYKGFKVMPYSTACKTPLSNFE----------AGLNYKDVS---------------DPAVM----------------- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 227 svgteLTFPL--KEQEGGLTVYTTRPDTLMGVSYMAVAAEHPLAKAaaeRHRD------VAE------FVDQCRNSKVAE 292
Cdd:PLN02882 207 -----VSFPIvgDPDNASFVAWTTTPWTLPSNLALCVNPNFTYVKV---RNKYtgkvyiVAEsrlsalPTAKPKSKKGSK 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 293 AELAT-----MEK-KGIDTGFKAIHPL-------TQEEIPVWVANFVLTDYGTGALMAVPGHDERDHEFAVKYKLPIK-- 357
Cdd:PLN02882 279 PENAAegyevLAKvPGSSLVGKKYEPLfdyfsefSDTAFRVVADDYVTDDSGTGVVHCAPAFGEDDYRVCLANGIIEKgg 358
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 358 QVIAPNDSR------------------DIDIQEqAFTEKGVLVSSGK----------------YSGLTS-----EEAFEE 398
Cdd:PLN02882 359 NLPVPVDDDgcftekvtdfsgryvkdaDKDIIA-AIKAKGRLVKSGSithsypfcwrsdtpliYRAVPSwfvkvEEIKDR 437
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 399 I----------ADYLEAqgigKRTVNY--RLRDWGVSRQRYWGAPIPMMTLEDGTEMPVPD--DQLPVRLPEDVE----- 459
Cdd:PLN02882 438 LlennkqtywvPDYVKE----KRFHNWleNARDWAVSRSRFWGTPLPIWISDDGEEVVVIGsiAELEKLSGVKVTdlhrh 513
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 460 -MDGVQSPIKADPEWckteyngQPATLETDTFDTFMES-SWYYARFCSPNYDKGMLDPAaanywLPVDQYIGGIEHA--- 534
Cdd:PLN02882 514 fIDHITIPSSRGPEF-------GVLRRVDDVFDCWFESgSMPYAYIHYPFENKELFEKN-----FPADFVAEGLDQTrgw 581
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 535 --ILHLLYARFFHKllrdvglvnssEPFKRLLTQGMVLAEtyyrneanggktwynpadvtverDGKgqvvravlksdgep 612
Cdd:PLN02882 582 fyTLMVLSTALFDK-----------PAFKNLICNGLVLAE-----------------------DGK-------------- 613
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 613 veiggvtKMSKSKNNGIDPQAIIDQHGADTVRLFMMfAAP--PEQSLEWSDSGVEG-----------AHRFL----KRLw 675
Cdd:PLN02882 614 -------KMSKSLKNYPDPNEVIDKYGADALRLYLI-NSPvvRAEPLRFKEEGVFGvvkdvflpwynAYRFLvqnaKRL- 684
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 676 rmvnEHTAGGEAPAVDPASLNGAQKDLRR----KTHETIAKVSDD---------ISRRLTFNTAIAAVMELLNE---VGR 739
Cdd:PLN02882 685 ----EVEGGAPFVPLDLAKLQNSANVLDRwinsATQSLVKFVREEmgayrlytvVPYLVKFIDNLTNIYVRFNRkrlKGR 760
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 740 LSDDEPQTR-AVRQEALDTAVLVLSPIVPHICHNLWQAL-----GHSDTVVDASWPVADESAMVR------SEIEVVLQV 807
Cdd:PLN02882 761 TGEEDCRTAlSTLYNVLLTSCKVMAPFTPFFTEVLYQNLrkvlpGSEESIHYCSFPQVDEGELDErieqsvSRMQTVIEL 840
|
970 980
....*....|....*....|..
gi 665842076 808 NGKVRAKENVPAdigKTDLEKL 829
Cdd:PLN02882 841 ARNIRERHNKPL---KTPLKEM 859
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
35-224 |
1.06e-23 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 104.29 E-value: 1.06e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 35 YYCLSMFPYPSGKLHMGHVRNYTIGDVISRYQRMQGKNVMQPMGWDAFGLPAENAAIANKSAPAKWTRSNIDYMKNQLKQ 114
Cdd:pfam09334 1 ILVTTALPYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEKEGITPEELVDRYHEIHREDFKK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 115 LGFGYD-WSRelaTCDPEYYRWEQWFFARLYEKGLVYKKMSTVNWDPVDQTVLANEQV---------VDGRGWR---SGA 181
Cdd:pfam09334 81 FNISFDdYGR---TTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYVegtcphcgsEDARGDQcenCGR 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665842076 182 LVEQ-----------------KKIPQWFIRITDYAEELLNDLEDME-GWPEQVKTMQRNWI 224
Cdd:pfam09334 158 HLEPtelinpkcvicgttpevKETEHYFFDLSKFQDKLREWIEENNpEWPENVKNMVLEWL 218
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
42-209 |
1.38e-22 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 102.65 E-value: 1.38e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 42 PYPSGKLHMGHVRNYTIGDVISRYQRMQGKNVMQPMGWDAFGLPAENAAIANKSAPAKWTRSNIDYMKNQLKQLGFGYD- 120
Cdd:PRK11893 10 YYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHGQKIQRKAEEAGISPQELADRNSAAFKRLWEALNISYDd 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 121 WSRelaTCDPEYYRWEQWFFARLYEKGLVYKKmSTVNWDPV-DQTVLANEQVVDGRGW--RSGALVEQKKIPQWFIRITD 197
Cdd:PRK11893 90 FIR---TTDPRHKEAVQEIFQRLLANGDIYLG-KYEGWYCVrCEEFYTESELIEDGYRcpPTGAPVEWVEEESYFFRLSK 165
|
170
....*....|..
gi 665842076 198 YAEELLNDLEDM 209
Cdd:PRK11893 166 YQDKLLELYEAN 177
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
700-820 |
2.15e-17 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 79.75 E-value: 2.15e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 700 KDLRRKTHETIAKVSDDISRrLTFNTAIAAVMELL-NEV---------GRLSDDEPQTRAVR--QEALDTAVLVLSPIVP 767
Cdd:pfam08264 2 RWILSRLNKLIKEVTEAYEN-YRFNTAAQALYEFFwNDLsdwylelikDRLYGEEPDSRAQTtlYEVLETLLRLLAPFMP 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 665842076 768 HICHNLWQalghSDTVVDASWPVADESAMVRSEIEV-----VLQVNGKVRAKENVPAD 820
Cdd:pfam08264 81 FITEELWQ----KESIHLAPWPEDAELEEAELEEAFelrqeIVQAIRKLRSELKIKKS 134
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
606-781 |
2.06e-14 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 76.84 E-value: 2.06e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 606 LKSDGEpveiggvtKMSKSKNNGIDPQAIIDQHGADTVRLFMMFAAPPEQSLEWSDSGVEG------AHRF---LKRLWR 676
Cdd:PRK11893 293 LTLDGE--------KMSKSLGNVIDPFDLVDEYGVDAVRYFLLREIPFGQDGDFSREAFINrinadlANDLgnlAQRTLS 364
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 677 MVNeHTAGGEAPavDPASLNGAQKDLRRKTHETIAKVSDDISrRLTFNTAIAAVMELLNEVGRLSDD-EP-QTRAVRQEA 754
Cdd:PRK11893 365 MIA-KNFDGKVP--EPGALTEADEALLEAAAALLERVRAAMD-NLAFDKALEAILALVRAANKYIDEqAPwSLAKTDPER 440
|
170 180 190
....*....|....*....|....*....|....*....
gi 665842076 755 LDT------------AVLvLSPIVPHICHNLWQALGHSD 781
Cdd:PRK11893 441 LATvlytllevlrgiAVL-LQPVMPELAAKILDQLGVEE 478
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
42-224 |
6.80e-14 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 75.57 E-value: 6.80e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 42 PYPSGKLHMGHVRNYTIGDVISRYQRMQGKNVMQPMGWDAFGLPAENAAIANKSAPakwtRSNIDYMKNQ----LKQLGF 117
Cdd:PRK00133 11 PYANGPIHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEKEGITP----EELIARYHAEhkrdFAGFGI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 118 GYD-WSRelaTCDPEYYRWEQWFFARLYEKGLVYKKMSTVNWDPVDQTVLANEQVV---------DGRG----------- 176
Cdd:PRK00133 87 SFDnYGS---THSEENRELAQEIYLKLKENGYIYEKTIEQLYDPEKGMFLPDRFVKgtcpkcgaeDQYGdncevcgatys 163
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 665842076 177 ---------WRSGALVEQKKIPQWFIRITDYAEELLNDLEDMEGWPEQVKTMQRNWI 224
Cdd:PRK00133 164 ptelinpksAISGATPVLKESEHFFFKLPRFEEFLKEWITRSGELQPNVANKMKEWL 220
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
6-664 |
1.45e-13 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 75.00 E-value: 1.45e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 6 NPREVEQTAR--TFWETNETFKVKEE--PGKPKYYCLSMFPYPSGKLHMGHVRNYTIGDVISRYQRMQGKNVMQPMGWDA 81
Cdd:PTZ00427 71 NPNIVEEEEKvlKYWKSIDAFNTSNKlaKNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDC 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 82 FGLPA----ENAAIANKSAP----------AKWTRSNIDYMKNQLK---QLGFGYDWSRELATCDPEYYRWEQWFFARLY 144
Cdd:PTZ00427 151 HGLPIeyeiEKENNINKKEDilkmgidvynEKCRGIVLKYSNEWVKtveRIGRWIDFKNDYKTMDKTFMESVWWVFSELY 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 145 EKGLVYKKMSTVNWDPVDQTVLANEQVVdgrgwrsgalVEQKKIPQ-----WFIRITDY--AEELLNDLEDMEGWPEQVK 217
Cdd:PTZ00427 231 KNNYVYKSFKVMPYSCKCNTPISNFELN----------LNYKDTPDpsiiiSFVLCSDFpkVEEECNIEEDKQLLGEKYS 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 218 TM----QRNWI-GKSVGTELTFPLKEQEggLTVYTTRPDTLmgVSYMAVAA-EH--PLAKAAAERHRDVaeFVDQCR--- 286
Cdd:PTZ00427 301 VLynnkRENSNnGNNNSTNNVCYAQHSE--ILAWTTTPWTL--PSNLALCVnEHftYLRIHHVKSNRVV--IVGECRlew 374
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 287 ----------NSKVAE----AELATMEKKGIDTGFKAIHPLTQEEIPVWVANFVLTDYGTGALMAVPGHDERDHEFAVKY 352
Cdd:PTZ00427 375 imkelkwnveDLKIVNrfkgKELKGLRYKPLFTNFYEKYNFKERAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKN 454
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 353 KL--PIKQV-IAPNDS-----------RDIDIQE------QAFTEKGVLVSSG--------------------------K 386
Cdd:PTZ00427 455 GVidPEKNIfIDPLDAngyftneveevQNLYIKEadnvikKKLKNENRLLSNNtivhsypfcwrsdtpliyraipawfiR 534
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 387 YSGLTSEEAFEEIADYLEAQGIGKRTVNYRL---RDWGVSRQRYWGAPIP------MMT---------LEDGTEMPVPDD 448
Cdd:PTZ00427 535 VSNSTNELVKNNETTYWIPAHIKEKKFHNWIkdaKDWCISRNRYWGTPIPiwadekMETvicvesikhLEELSGVKNIND 614
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 449 qLPVRLPEDVEMD---GVQSP-IKADPEwckteyngqpatletdTFDTFMES-SWYYARFCSPnydkgmLDPAAANYW-- 521
Cdd:PTZ00427 615 -LHRHFIDHIEIKnpkGKTYPkLKRIPE----------------VFDCWFESgSMPYAKVHYP------FSTEKEDFHki 671
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 522 LPVDQYIGGIEHAilhllyARFFHKLLRDVGLVNSSEPFKRLLTQGMVLAetyyrneanggktwynpadvtverdgkgqv 601
Cdd:PTZ00427 672 FPADFIAEGLDQT------RGWFYTLLVISTLLFDKAPFKNLICNGLVLA------------------------------ 715
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665842076 602 vravlkSDGEpveiggvtKMSKSKNNGIDPQAIIDQHGADTVRLFMMFA-APPEQSLEWSDSGV 664
Cdd:PTZ00427 716 ------SDGK--------KMSKRLKNYPDPLYILDKYGADSLRLYLINSvAVRAENLKFQEKGV 765
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
620-791 |
3.28e-13 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 73.22 E-value: 3.28e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 620 KMSKSKNNGIDPQAIIDQHGADTVRLFMMFAAPPEQ--SLEWSD---------SGVEG--AHRFLKrlwrMVNEHTaGGE 686
Cdd:COG0143 327 KMSKSRGNVIDPDDLLDRYGPDALRYYLLREVPFGQdgDFSWEDfvarvnsdlANDLGnlASRTLS----MIHKYF-DGK 401
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 687 APAvdPASLNGAQKDLRRKTHETIAKVSDDISRRlTFNTAIAAVMELLNEVGRLSDD--------EPQTRAVRQ------ 752
Cdd:COG0143 402 VPE--PGELTEADEELLAEAEAALEEVAEAMEAF-EFRKALEEIMALARAANKYIDEtapwklakDEDPERLATvlytll 478
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 665842076 753 EALDTAVLVLSPIVPHICHNLWQALGHSDTVV---DASWPVA 791
Cdd:COG0143 479 EALRILAILLKPFLPETAEKILEQLGLEGDELtweDAGWPLP 520
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
613-757 |
5.71e-12 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 68.98 E-value: 5.71e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 613 VEIGGVtKMSKSKNNGIDPQAIIDQHGADTVRLFMMfAAPPEQSLEWSDSGVEGAHRFLKRLWRMVNEHTAGGEAPAVDP 692
Cdd:COG0215 259 LTVNGE-KMSKSLGNFFTVRDLLKKYDPEVLRFFLL-SAHYRSPLDFSEEALEEAEKALERLYNALRRLEEALGAADSSA 336
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665842076 693 ASLNGAQKDLrrkthetIAKVSDDisrrltFNT--AIAAVMELLNEVGRLSDDEPqTRAVRQEALDT 757
Cdd:COG0215 337 EEIEELREEF-------IAAMDDD------FNTpeALAVLFELVREINKALDEGE-DKAALAALAAL 389
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
43-151 |
1.27e-11 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 68.29 E-value: 1.27e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 43 YPSGKLHMGHVrnYT--IGDVISRYQRMQGKNVMQPMGWDAFGLPAENAAIANKSAPAKWTRSNIDYMKNQLKQLGFGYD 120
Cdd:PRK12267 14 YPNGKPHIGHA--YTtiAADALARYKRLQGYDVFFLTGTDEHGQKIQQAAEKAGKTPQEYVDEISAGFKELWKKLDISYD 91
|
90 100 110
....*....|....*....|....*....|.
gi 665842076 121 wsRELATCDPEYYRWEQWFFARLYEKGLVYK 151
Cdd:PRK12267 92 --KFIRTTDERHKKVVQKIFEKLYEQGDIYK 120
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
8-176 |
3.85e-10 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 63.94 E-value: 3.85e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 8 REVEQTARTFWETNETFKVK--EEPGKPKYYCLSMFPYP--SGKLHMGHVRNYTIGDVISRYQRMQGKNVMQPMGWDAFG 83
Cdd:PLN02959 16 LEIEVAVQKWWEEEKVFEAEagDEPPKPGEKFFGNFPYPymNGLLHLGHAFSLSKLEFAAAYHRLRGANVLLPFAFHCTG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 84 LP----------------------------------AENAAIANKSAPAK------------------W--------TRS 103
Cdd:PLN02959 96 MPikasadklareiqqygnppvfpeededeaaavaaAKAEAEAAAAPPDKfkgkkskavaksgtqkyqWeimrsfglPDS 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 104 NI----------DYM----KNQLKQLGFGYDWSRELATCD--PEYYRWEQWFFARLYEKGLVYKKMSTVNWDPVDQTVLA 167
Cdd:PLN02959 176 EIakfqdpyhwlSYFpplaKEDLKAFGLGCDWRRSFITTDvnPYYDAFVRWQFRKLKKKGKIVKDKRYTIYSPLDGQPCA 255
|
....*....
gi 665842076 168 NEQVVDGRG 176
Cdd:PLN02959 256 DHDRASGEG 264
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
619-778 |
1.11e-08 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 58.66 E-value: 1.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 619 TKMSKSKNNGIDPQAIIDQHGADTVRLFMMFAAPPEQslewsDsGV--EGA--HRF-----------LKRLWRMVNEHtA 683
Cdd:PRK12267 298 GKMSKSKGNVVDPEELVDRYGLDALRYYLLREVPFGS-----D-GDfsPEAlvERInsdlandlgnlLNRTVAMINKY-F 370
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 684 GGEAPAvdPASLNGAQKDLRRKTHETIAKVSDDIsRRLTFNTAIAAVMELLNEVGRLSDD-EPQTRA---VRQEALDT-- 757
Cdd:PRK12267 371 DGEIPA--PGNVTEFDEELIALAEETLKNYEELM-EELQFSRALEEVWKLISRANKYIDEtAPWVLAkdeGKKERLATvm 447
|
170 180 190
....*....|....*....|....*....|.
gi 665842076 758 ----------AVLvLSPIVPHICHNLWQALG 778
Cdd:PRK12267 448 yhlaeslrkvAVL-LSPFMPETSKKIFEQLG 477
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
664-777 |
2.11e-07 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 50.63 E-value: 2.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 664 VEGAHRFLKRLW---RMVNEHTAGGEAPAVDPASLNGAQKDLRRKTHETIAKVSDDISRRLtFNTAIAAVME-LLNEV-- 737
Cdd:cd07962 6 VEGGRNFCNKLWnaaRFVLMNLEDDDEPEEDPESLSLADRWILSRLNKTVEEVTEALENYR-FSEAATALYEfFWNDFcd 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 665842076 738 -------GRL-SDDEPQTRAVRQ---EALDTAVLVLSPIVPHICHNLWQAL 777
Cdd:cd07962 85 wylelvkPRLyGEDEEEKKAARAtlyYVLETILRLLHPFMPFITEELWQRL 135
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
661-760 |
3.17e-06 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 46.73 E-value: 3.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 661 DSGVEGAHRFLKRLWRMVNE--HTAGGEAPAVDPASLNGAQKDLRRKTHETIAKVSDDIsRRLTFNTAIAAVMELLNEVG 738
Cdd:cd07375 1 EERLKQARAFLNRLYRLLSFfrKALGGTQPKWDNELLEEADRELLARLQEFIKRTTNAL-EALDPTTAVQELFKFTNELN 79
|
90 100
....*....|....*....|..
gi 665842076 739 RLSDDEPqtRAVRQEALDTAVL 760
Cdd:cd07375 80 WYLDELK--PALQTEELREAVL 99
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
43-151 |
1.94e-05 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 48.17 E-value: 1.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 43 YPSGKLHMGHVRNYTIGDVISRYQRMQGKNVMQPMGWDAFGLPAENAAIANKSAPAKWTRSNIDYMKNQLKQLGFGYDws 122
Cdd:PLN02224 79 YVNAPPHMGSAYTTIAADSIARFQRLLGKKVIFITGTDEHGEKIATSAAANGRNPPEHCDIISQSYRTLWKDLDIAYD-- 156
|
90 100
....*....|....*....|....*....
gi 665842076 123 RELATCDPEYYRWEQWFFARLYEKGLVYK 151
Cdd:PLN02224 157 KFIRTTDPKHEAIVKEFYARVFANGDIYR 185
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
659-777 |
1.82e-04 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 41.81 E-value: 1.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 659 WSDSGVEGAHRFLKRLWRMVNEHTAGGEapavDPASLNGAQKDLRRKTHETIAKVSDDISR---RLTFNTAIAAVMELLN 735
Cdd:cd07959 1 FREEEANSAILRLERFYELAEELIETEG----ELEELTFIDRWLLSRLNRLIKETTEAYENmqfREALKEGLYELQNDLD 76
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 665842076 736 EVGRLSDDEPQTRAVRqEALDTAVLVLSPIVPHICHNLWQAL 777
Cdd:cd07959 77 WYRERGGAGMNKDLLR-RFIEVWTRLLAPFAPHLAEEIWHEL 117
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
620-662 |
5.26e-04 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 43.43 E-value: 5.26e-04
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 665842076 620 KMSKSKNNGIDPQAIIDQHGADTVRLFMMFAAPPEQSLEWSDS 662
Cdd:pfam09334 324 KMSKSRGNVVWPSEALDRFPPDALRYYLARNRPETKDTDFSWE 366
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
705-802 |
1.26e-03 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 40.61 E-value: 1.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842076 705 KTHETIAKVSDDISR-RLTfnTAIAAVMELLNEV---------GRL--SDDEPQTRAVRQ---EALDTAVLVLSPIVPHI 769
Cdd:cd07961 55 RLNSLIKEVTEEMEAyDLY--TAVRALLEFIDELtnwyirrnrKRFwgEEGDDDKLAAYAtlyEVLLTLSRLMAPFTPFI 132
|
90 100 110
....*....|....*....|....*....|....*...
gi 665842076 770 CHNLWQALGHSDTVVDAS-----WPVADESaMVRSEIE 802
Cdd:cd07961 133 TEEIYQNLRRELGDAPESvhlldWPEVDES-LIDEELE 169
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
755-793 |
2.95e-03 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 41.21 E-value: 2.95e-03
10 20 30 40
....*....|....*....|....*....|....*....|
gi 665842076 755 LDTAVLVLSPIVPHICHNLWQALGHSD-TVVDASWPVADE 793
Cdd:PLN02959 855 MDVQTRLITPICPHYAEHVWREILKKEgFAVTAGWPVAGE 894
|
|
| |
