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Conserved domains on  [gi|665842216|ref|WP_031210333|]
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MULTISPECIES: response regulator transcription factor [Marinobacter]

Protein Classification

transcriptional regulator( domain architecture ID 1003377)

transcriptional regulator may belong to the NarL family and contain a C-terminal helix-turn-helix DNA-binding domain and an N-terminal REC domain, thereby functioning as a response regulator

Gene Ontology:  GO:0003677|GO:0006355|GO:0000160
PubMed:  16740923

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10651 super family cl32550
transcriptional regulator NarL; Provisional
 7-210 2.60e-29

transcriptional regulator NarL; Provisional


The actual alignment was detected with superfamily member PRK10651:

Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 108.96  E-value: 2.60e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   7 ILIADDHPLFREAISSVIASGFAGTEILETDDLDSALEITREnDDLDLILLDLNMPGMHGLNGLISLRNEAPTIPVVIVS 86
Cdd:PRK10651   9 ILLIDDHPMLRTGVKQLISMAPDITVVGEASNGEQGIELAES-LDPDLILLDLNMPGMNGLETLDKLREKSLSGRIVVFS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216  87 AEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQQILNGNVYLPSDIIRTGKESSQRRVRSDENPISpellnSLTRRQLL 166
Cdd:PRK10651  88 VSNHEEDVVTALKRGADGYLLKDMEPEDLLKALQQAAAGEMVLSEALTPVLAASLRANRATTERDVN-----QLTPRERD 162

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 665842216 167 VLERMAKGESNKQIAYNLNIAETTVKAHVSAILRKLGVHNRVQA 210
Cdd:PRK10651 163 ILKLIAQGLPNKMIARRLDITESTVKVHVKHMLKKMKLKSRVEA 206
 
Name Accession Description Interval E-value
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 7-210 2.60e-29

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 108.96  E-value: 2.60e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   7 ILIADDHPLFREAISSVIASGFAGTEILETDDLDSALEITREnDDLDLILLDLNMPGMHGLNGLISLRNEAPTIPVVIVS 86
Cdd:PRK10651   9 ILLIDDHPMLRTGVKQLISMAPDITVVGEASNGEQGIELAES-LDPDLILLDLNMPGMNGLETLDKLREKSLSGRIVVFS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216  87 AEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQQILNGNVYLPSDIIRTGKESSQRRVRSDENPISpellnSLTRRQLL 166
Cdd:PRK10651  88 VSNHEEDVVTALKRGADGYLLKDMEPEDLLKALQQAAAGEMVLSEALTPVLAASLRANRATTERDVN-----QLTPRERD 162

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 665842216 167 VLERMAKGESNKQIAYNLNIAETTVKAHVSAILRKLGVHNRVQA 210
Cdd:PRK10651 163 ILKLIAQGLPNKMIARRLDITESTVKVHVKHMLKKMKLKSRVEA 206
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 7-124 3.01e-29

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 105.67  E-value: 3.01e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   7 ILIADDHPLFREAISSVIASGFAGTEILETDDLDSALEITRENDDLDLILLdLNMPGMHGLNGLISLRNEAPTIPVVIVS 86
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLESEPDIEVVGEAADGEEALALLRELRPDVVLMD-LSMPGMDGIEALRRLRRRYPDLKVIVLT 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 665842216  87 AEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQQILN 124
Cdd:cd17535   80 AHDDPEYVLRALKAGAAGYLLKDSSPEELIEAIRAVAA 117
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 7-211 7.24e-26

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 99.40  E-value: 7.24e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   7 ILIADDHPLFREAISSVIAS-GFA------GTEILETDDLDSA----LEItrenddldlilldlNMPGMHGLNGLISLRN 75
Cdd:COG4566    2 VYIVDDDEAVRDSLAFLLESaGLRvetfasAEAFLAALDPDRPgcllLDV--------------RMPGMSGLELQEELAA 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216  76 EAPTIPVVIVSAEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQQILNgnvylpSDIIRTGKESSQRRVRsdenpispE 155
Cdd:COG4566   68 RGSPLPVIFLTGHGDVPMAVRAMKAGAVDFLEKPFDDQALLDAVRRALA------RDRARRAERARRAELR--------A 133

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 665842216 156 LLNSLTRRQLLVLERMAKGESNKQIAYNLNIAETTVKAHVSAILRKLGVHNRVQAI 211
Cdd:COG4566  134 RLASLTPREREVLDLVVAGLSNKQIARELGISPRTVEVHRANVMEKLGARSLAELV 189
GerE pfam00196
Bacterial regulatory proteins, luxR family;
159-214 9.30e-22

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 84.56  E-value: 9.30e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 665842216  159 SLTRRQLLVLERMAKGESNKQIAYNLNIAETTVKAHVSAILRKLGVHNRVQAILSA 214
Cdd:pfam00196   2 SLSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELVRMA 57
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 157-214 3.43e-20

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 80.26  E-value: 3.43e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 665842216   157 LNSLTRRQLLVLERMAKGESNKQIAYNLNIAETTVKAHVSAILRKLGVHNRVQAILSA 214
Cdd:smart00421   1 LASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
 
Name Accession Description Interval E-value
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 7-210 2.60e-29

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 108.96  E-value: 2.60e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   7 ILIADDHPLFREAISSVIASGFAGTEILETDDLDSALEITREnDDLDLILLDLNMPGMHGLNGLISLRNEAPTIPVVIVS 86
Cdd:PRK10651   9 ILLIDDHPMLRTGVKQLISMAPDITVVGEASNGEQGIELAES-LDPDLILLDLNMPGMNGLETLDKLREKSLSGRIVVFS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216  87 AEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQQILNGNVYLPSDIIRTGKESSQRRVRSDENPISpellnSLTRRQLL 166
Cdd:PRK10651  88 VSNHEEDVVTALKRGADGYLLKDMEPEDLLKALQQAAAGEMVLSEALTPVLAASLRANRATTERDVN-----QLTPRERD 162

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 665842216 167 VLERMAKGESNKQIAYNLNIAETTVKAHVSAILRKLGVHNRVQA 210
Cdd:PRK10651 163 ILKLIAQGLPNKMIARRLDITESTVKVHVKHMLKKMKLKSRVEA 206
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 7-124 3.01e-29

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 105.67  E-value: 3.01e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   7 ILIADDHPLFREAISSVIASGFAGTEILETDDLDSALEITRENDDLDLILLdLNMPGMHGLNGLISLRNEAPTIPVVIVS 86
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLESEPDIEVVGEAADGEEALALLRELRPDVVLMD-LSMPGMDGIEALRRLRRRYPDLKVIVLT 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 665842216  87 AEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQQILN 124
Cdd:cd17535   80 AHDDPEYVLRALKAGAAGYLLKDSSPEELIEAIRAVAA 117
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 7-211 7.24e-26

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 99.40  E-value: 7.24e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   7 ILIADDHPLFREAISSVIAS-GFA------GTEILETDDLDSA----LEItrenddldlilldlNMPGMHGLNGLISLRN 75
Cdd:COG4566    2 VYIVDDDEAVRDSLAFLLESaGLRvetfasAEAFLAALDPDRPgcllLDV--------------RMPGMSGLELQEELAA 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216  76 EAPTIPVVIVSAEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQQILNgnvylpSDIIRTGKESSQRRVRsdenpispE 155
Cdd:COG4566   68 RGSPLPVIFLTGHGDVPMAVRAMKAGAVDFLEKPFDDQALLDAVRRALA------RDRARRAERARRAELR--------A 133

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 665842216 156 LLNSLTRRQLLVLERMAKGESNKQIAYNLNIAETTVKAHVSAILRKLGVHNRVQAI 211
Cdd:COG4566  134 RLASLTPREREVLDLVVAGLSNKQIARELGISPRTVEVHRANVMEKLGARSLAELV 189
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
3-210 1.74e-25

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 98.77  E-value: 1.74e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   3 PVYKILIADDHPLFREAISSVIASGFAGTEILETDDLDSALEITREnDDLDLILLDLNMPGMHGLNGLISLRNEAPTIPV 82
Cdd:PRK10403   5 TPFQVLIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANR-LDPDVILLDLNMKGMSGLDTLNALRRDGVTAQI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216  83 VIVSAEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQQILNGNVYLPSDIIRTGKEssQRRVRSDENPISpellnSLTR 162
Cdd:PRK10403  84 IILTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRAGAKGSKVFSERVNQYLRE--REMFGAEEDPFS-----VLTE 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 665842216 163 RQLLVLERMAKGESNKQIAYNLNIAETTVKAHVSAILRKLGVHNRVQA 210
Cdd:PRK10403 157 RELDVLHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAA 204
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 6-212 7.38e-22

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 86.87  E-value: 7.38e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   6 KILIADDHPLFREAISSVIASGFAGTEILETDDLDSALEITRENDDLDLILLDlNMPGMHGLnglislrneaptipvviv 85
Cdd:COG2197    3 RVLIVDDHPLVREGLRALLEAEPDIEVVGEAADGEEALELLEELRPDVVLLDI-RMPGMDGL------------------ 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216  86 saeedkqvvlqaitygacgfitksspraqmtDAIQQILngnvylpsdiirtgkessqrrvrsdenpispellnslTRRQL 165
Cdd:COG2197   64 -------------------------------EALRRLL-------------------------------------TPRER 75

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 665842216 166 LVLERMAKGESNKQIAYNLNIAETTVKAHVSAILRKLGVHNRVQAIL 212
Cdd:COG2197   76 EVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVL 122
GerE pfam00196
Bacterial regulatory proteins, luxR family;
159-214 9.30e-22

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 84.56  E-value: 9.30e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 665842216  159 SLTRRQLLVLERMAKGESNKQIAYNLNIAETTVKAHVSAILRKLGVHNRVQAILSA 214
Cdd:pfam00196   2 SLSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELVRMA 57
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
1-211 2.80e-20

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 84.93  E-value: 2.80e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   1 MDPVyKILIADDHPLFREAISSVIASGFAGTEILETDDLDSALEITReNDDLDLILLDLNMPGMHGLNGLISLRNEAPTI 80
Cdd:PRK09935   1 MKPA-SVIIMDTHPIIRMSIEVLLQKNSELQIVLKTDDYRITIDYLR-TRPVDLIIMDIDLPGTDGFTFLKRIKQIQSTV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216  81 PVVIVSAEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQQILNGNVYLPSDIIRTGKESSQRRVRSDENPISpellnsl 160
Cdd:PRK09935  79 KVLFLSSKSECFYAGRAIQAGANGFVSKCNDQNDIFHAVQMILSGYTFFPSETLNYIKSNKCSTNSSTDTVLS------- 151

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 665842216 161 tRRQLLVLERMAKGESNKQIAYNLNIAETTVKAHVSAILRKLGVHNRVQAI 211
Cdd:PRK09935 152 -NREVTILRYLVSGLSNKEIADQLLLSNKTVSAHKSNIYGKLGLHSIVELI 201
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 157-214 3.43e-20

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 80.26  E-value: 3.43e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 665842216   157 LNSLTRRQLLVLERMAKGESNKQIAYNLNIAETTVKAHVSAILRKLGVHNRVQAILSA 214
Cdd:smart00421   1 LASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 7-120 8.17e-20

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 81.04  E-value: 8.17e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216    7 ILIADDHPLFREAISSVIASgfAGTEILETDDLDSALEITRENDDLDLILLdLNMPGMHGLNGLISLRNEAPTIPVVIVS 86
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEK--EGYVVAEADDGKEALELLKEERPDLILLD-INMPGMDGLELLKRIRRRDPTTPVIILT 77

                          90       100       110
                  ....*....|....*....|....*....|....
gi 665842216   87 AEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQ 120
Cdd:pfam00072  78 AHGDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 160-214 7.75e-19

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 76.80  E-value: 7.75e-19
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 665842216 160 LTRRQLLVLERMAKGESNKQIAYNLNIAETTVKAHVSAILRKLGVHNRVQAILSA 214
Cdd:cd06170    1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYA 55
GerE COG5905
Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell ...
 159-214 2.80e-18

Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444607 [Multi-domain]  Cd Length: 76  Bit Score: 76.15  E-value: 2.80e-18
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 665842216 159 SLTRRQLLVLERMAKGESNKQIAYNLNIAETTVKAHVSAILRKLGVHNRVQAILSA 214
Cdd:COG5905   12 LLTKREREVLELLAEGLTNKEIARQLFISEKTVKNHVSNILRKLGVRNRVQAVVWA 67
PRK15369 PRK15369
two component system response regulator;
4-211 5.70e-16

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 73.57  E-value: 5.70e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   4 VYKILIADDHPLFREAISSVIASGFAGTEILETDD-LD--SALEITRENDDLDLIlldlNMPGMHGLNGLISLRNEAPTI 80
Cdd:PRK15369   3 NYKILLVDDHELIINGIKNMLAPYPRYKIVGQVDNgLEvyNACRQLEPDIVILDL----GLPGMNGLDVIPQLHQRWPAM 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216  81 PVVIVSAEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQQILNGNVYL-PS----DIIRTGKEssqrrvrSDENPispe 155
Cdd:PRK15369  79 NILVLTARQEEHMASRTLAAGALGYVLKKSPQQILLAAIQTVAVGKRYIdPAlnreAILALLNA-------DDTNP---- 147

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 665842216 156 llNSLTRRQLLVLERMAKGESNKQIAYNLNIAETTVKAHVSAILRKLGVHNRVQAI 211
Cdd:PRK15369 148 --PLLTPRERQILKLITEGYTNRDIAEQLSISIKTVETHRLNMMRKLDVHKVAELL 201
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 6-108 1.02e-14

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 67.49  E-value: 1.02e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   6 KILIADDHPLFREAISSVIASGFAGTEILETDDLDSALEITRENDdldlilldlNMPGMHGLNGLISLRNEAPTIPVVIV 85
Cdd:COG4753    1 KVLIVDDEPLIREGLKRILEWEAGFEVVGEAENGEEALELLEEHKpdlv-itdiNMPGMDGLELLEAIRELDPDTKIIIL 79

                         90       100
                 ....*....|....*....|...
gi 665842216  86 SAEEDKQVVLQAITYGACGFITK 108
Cdd:COG4753   80 SGYSDFEYAQEAIKLGADDYLLK 102
PRK09483 PRK09483
response regulator; Provisional
 7-209 5.06e-14

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 68.21  E-value: 5.06e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   7 ILIADDHPLFREAISSVIASGFAGTEILETDDLDSALEITRENDDLDLILLDlNMPGMHGLNGLISLRNEAPTIPVVIVS 86
Cdd:PRK09483   4 VLLVDDHELVRAGIRRILEDIKGIKVVGEACCGEDAVKWCRTNAVDVVLMDM-NMPGIGGLEATRKILRYTPDVKIIMLT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216  87 AEEDKQV---VLQAityGACGFITKSSPRAQMTDAIQQILNGNVYLPSDIirtgkesSQRRVRSDENPISPELLNSLTRR 163
Cdd:PRK09483  83 VHTENPLpakVMQA---GAAGYLSKGAAPQEVVSAIRSVHSGQRYIASDI-------AQQMALSQIEPATENPFASLSER 152

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 665842216 164 QLLVLERMAKGESNKQIAYNLNIAETTVKAHVSAILRKLGVHNRVQ 209
Cdd:PRK09483 153 ELQIMLMITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNISGDVE 198
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
141-211 5.67e-14

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 67.86  E-value: 5.67e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665842216 141 SQRRVRSDENPISPELLNSLTRRQLLVLERMAKGESNKQIAYNLNIAETTVKAHVSAILRKLGVHNRVQAI 211
Cdd:COG2771  109 ALAALLLAALARLLARAPGLTPREREVLRLLAEGLTLKEIARILGISERTVRTHLKRIYRKLGVSSRAELV 179
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
8-203 1.04e-13

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 67.23  E-value: 1.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   8 LIADDHPLFREAISSVIASGfaGTEIL-ETDDLDSALEiTRENDDLDLILLDLNMPGMHGLNGLISLRNEAPTIPVVIVS 86
Cdd:PRK09958   4 IIIDDHPLAIAAIRNLLIKN--DIEILaELTEGGSAVQ-RVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIVS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216  87 AEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQQILNGNVYLPSDIIR--TGKESSQRRvrsdenpispelLNSLTRRQ 164
Cdd:PRK09958  81 AKNDHFYGKHCADAGANGFVSKKEGMNNIIAAIEAAKNGYCYFPFSLNRfvGSLTSDQQK------------LDSLSKQE 148

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 665842216 165 LLVLERMAKGESNKQIAYNLNIAETTVKAHVSAILRKLG 203
Cdd:PRK09958 149 ISVMRYILDGKDNNDIAEKMFISNKTVSTYKSRLMEKLE 187
PRK10360 PRK10360
transcriptional regulator UhpA;
6-209 1.52e-13

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 66.54  E-value: 1.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   6 KILIADDHPLFReaissviaSGFAGTEILETDdldsaLEITREndDLDLILLDLNMPG-----------MHGLNGLISLR 74
Cdd:PRK10360   3 TVALIDDHLIVR--------SGFAQLLGLEPD-----LQVVAE--FGSGREALAGLPGrgvqvcicdisMPDISGLELLS 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216  75 NEAPTIPVVIVSAEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQQILNGNVYLPSDIIRtgKESSQRRvrsdenpisp 154
Cdd:PRK10360  68 QLPKGMATIMLSVHDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAI--KLASGRQ---------- 135

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 665842216 155 ellNSLTRRQLLVLERMAKGESNKQIAYNLNIAETTVKAHVSAILRKLGVHNRVQ 209
Cdd:PRK10360 136 ---DPLTKRERQVAEKLAQGMAVKEIAAELGLSPKTVHVHRANLMEKLGVSNDVE 187
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 5-132 3.24e-13

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 64.22  E-value: 3.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   5 YKILIADDHPLFREAISSVIASGFAGTEILETDDLDSALEITRENDdldlilldLNMPGMHGLNGLISLRNEAPTIPVVI 84
Cdd:COG4565    4 IRVLIVEDDPMVAELLRRYLERLPGFEVVGVASSGEEALALLAEHRpdli-lldIYLPDGDGLELLRELRARGPDVDVIV 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 665842216  85 VSAEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQQILNGNVYLPSD 132
Cdd:COG4565   83 ITAARDPETVREALRAGVVDYLIKPFTFERLREALERYLEYRRLLRED 130
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 6-124 6.87e-13

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 66.91  E-value: 6.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   6 KILIADDHPLFREAISSVIASgfAGTEILETDDLDSALEITRENDdldlilldlNMPGMHGLNGLISLRNEAPTIPVVIV 85
Cdd:COG2204    4 RILVVDDDPDIRRLLKELLER--AGYEVETAASGEEALALLREEPpdlv-lldlRMPGMDGLELLRELRALDPDLPVILL 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 665842216  86 SAEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQQILN 124
Cdd:COG2204   81 TGYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERALE 119
MalT COG2909
ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];
163-214 1.42e-12

ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];


Pssm-ID: 442153 [Multi-domain]  Cd Length: 184  Bit Score: 63.57  E-value: 1.42e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 665842216 163 RQLLVLERMAKGESNKQIAYNLNIAETTVKAHVSAILRKLGVHNRVQAILSA 214
Cdd:COG2909  126 LAALRRRLLAEGLSNKEIAERLFISVNTVKTHLRNIYRKLGVRSRTEAVARA 177
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 8-108 4.38e-12

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 60.32  E-value: 4.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   8 LIADDHPLFREAISSVIASgfAGTEILETDDLDSALEITRENDdldlilldLNMPGMHGLNGLISLRNEAPTIPVVIVSA 87
Cdd:cd00156    1 LIVDDDPAIRELLKSLLER--EGYEVDTAADGEEALELLREERpdlv-lldLMMPGMDGLELLRKLRELPPDIPVIVLTA 77

                         90       100
                 ....*....|....*....|.
gi 665842216  88 EEDKQVVLQAITYGACGFITK 108
Cdd:cd00156   78 KADEEDAVRALELGADDYLVK 98
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 6-126 5.79e-12

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 60.63  E-value: 5.79e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   6 KILIADDHPLFREAISSVIASgfAGTEILETDDLDSALEITRENDdldlilldlNMPGMHGLNGLISLRNEA--PTIPVV 83
Cdd:COG0784    7 RILVVDDNPDNRELLRRLLER--LGYEVTTAEDGAEALELLRAGPpdli-lldiNMPGMDGLELLRRIRALPrlPDIPII 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 665842216  84 IVSAEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQQILNGN 126
Cdd:COG0784   84 ALTAYADEEDRERALEAGADDYLTKPVDPEELLEALRRLLARA 126
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 5-203 9.71e-12

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 61.90  E-value: 9.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   5 YKILIADDHPLFREAISSVIASgfAGTEILETDDLDSALEITRENDdldlilldlNMPGMHGLNGLISLRNEAPTIPVVI 84
Cdd:COG0745    2 PRILVVEDDPDIRELLADALER--EGYEVDTAADGEEALELLEEERpdli-lldlMLPGMDGLEVCRRLRARPSDIPIIM 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216  85 VSAEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQQIL---NGNVYLPSDIIRTgkesSQRRVRSDENPIS-----PEL 156
Cdd:COG0745   79 LTARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLrrrAAEVLRVGDLLDL----AAREVTRDGEPVEltpkeFRL 154

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 665842216 157 LNSLTRRQLLVLERMAKGESNKQIAYnlnIAETTVKAHVSAILRKLG 203
Cdd:COG0745  155 LELLMRNPGRVVSREQLLEEVWGYDY---GDDRTVDVHISRLRKKLE 198
fixJ PRK09390
response regulator FixJ; Provisional
 61-206 2.81e-11

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 60.40  E-value: 2.81e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216  61 MPGMHGLNGLISLRNEAPTIPVVIVSAEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQQILngnvylpsdiirtgkES 140
Cdd:PRK09390  57 MPGIDGIELLRRLKARGSPLPVIVMTGHGDVPLAVEAMKLGAVDFIEKPFEDERLIGAIERAL---------------AQ 121

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665842216 141 SQRRVRSDenPISPEL---LNSLTRRQLLVLERMAKGESNKQIAYNLNIAETTVKAHVSAILRKLGVHN 206
Cdd:PRK09390 122 APEAAKSE--AVAADIrarIASLSERERQVMDGLVAGLSNKVIARDLDISPRTVEVYRANVMTKMQAGS 188
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 6-108 3.26e-11

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 58.37  E-value: 3.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   6 KILIADDHPLFREAISSVIA-SGFagtEILETDDLDSALEITRENDDLDLILLDlNMPGMHGLNGLISLRNEAPTIPVVI 84
Cdd:cd17555    2 TILVIDDDEVVRESIAAYLEdSGF---QVLQAADGRQGLELFRSEQPDLVLCDL-RMPEMDGLEVLKQITKESPDTPVIV 77

                         90       100
                 ....*....|....*....|....
gi 665842216  85 VSAEEDKQVVLQAITYGACGFITK 108
Cdd:cd17555   78 VSGAGVMSDAVEALRLGAWDYLTK 101
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 5-108 4.01e-11

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 59.54  E-value: 4.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   5 YKILIADDHPLFREAISSVIASgfAGTEILETDDLDSALEITRENDdldlilldlNMPGMHGLnGLIS-LRNEAPT--IP 81
Cdd:COG3706    2 ARILVVDDDPTNRKLLRRLLEA--AGYEVVEAADGEEALELLQEHRpdli-lldlEMPDMDGL-ELCRrLRADPRTadIP 77

                         90       100
                 ....*....|....*....|....*..
gi 665842216  82 VVIVSAEEDKQVVLQAITYGACGFITK 108
Cdd:COG3706   78 IIFLTALDDEEDRARALEAGADDYLTK 104
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 7-122 2.12e-10

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 56.19  E-value: 2.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   7 ILIADDHPLFREAISSVI---ASGFagTEILETDDLDSALEITRENDdldlilldlNMPGMHGLNgLIS-LRNEAPTIPV 82
Cdd:cd17536    1 VLIVDDEPLIREGLKKLIdweELGF--EVVGEAENGEEALELIEEHKpdiv-itdiRMPGMDGLE-LIEkIRELYPDIKI 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 665842216  83 VIVSAEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQQI 122
Cdd:cd17536   77 IILSGYDDFEYAQKAIRLGVVDYLLKPVDEEELEEALEKA 116
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 7-123 2.81e-10

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 55.82  E-value: 2.81e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   7 ILIADDHPLFREAISSVI------------ASGFAGTEILETDDLDSALeitrenddldlilLDLNMPGMHGLNGLISLR 74
Cdd:cd19931    1 VLLIDDHPLLRKGIKQLIeldpdftvvgeaSSGEEGIELAERLDPDLIL-------------LDLNMKGMSGLDTLKALR 67

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 665842216  75 NEAPTIPVVIVSAEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQQIL 123
Cdd:cd19931   68 EEGVSARIVILTVSDAEDDVVTALRAGADGYLLKDMEPEDLLEALKQAA 116
PRK04841 PRK04841
HTH-type transcriptional regulator MalT;
140-211 4.08e-10

HTH-type transcriptional regulator MalT;


Pssm-ID: 235315 [Multi-domain]  Cd Length: 903  Bit Score: 58.80  E-value: 4.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216 140 SSQRRVRS---DENPIS--------PELLNS--LTRRQLLVLERMAKGESNKQIAYNLNIAETTVKAHVSAILRKLGVHN 206
Cdd:PRK04841 806 NQHHRHKFahfDEAFVEkllnhpdvPELIRTspLTQREWQVLGLIYSGYSNEQIAGELDVAATTIKTHIRNLYQKLGIAH 885


                 ....*
gi 665842216 207 RVQAI 211
Cdd:PRK04841 886 RQEAV 890
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 6-123 8.98e-10

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 56.71  E-value: 8.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   6 KILIADDHPLFREAISSVIASgfAGTEILETDDLDSALEITREND-------DldlilldlNMPGMHGLN--GLISLRNE 76
Cdd:COG3437    8 TVLIVDDDPENLELLRQLLRT--LGYDVVTAESGEEALELLLEAPpdlilldV--------RMPGMDGFEllRLLRADPS 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 665842216  77 APTIPVVIVSAEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQQIL 123
Cdd:COG3437   78 TRDIPVIFLTALADPEDRERALEAGADDYLTKPFDPEELLARVRNAL 124
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 5-123 1.27e-09

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 54.32  E-value: 1.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   5 YKILIADDHPLFREAISSVIAS-------GFA--GTEILE----------TDDLdsaleitrenddldlilldlNMPGMH 65
Cdd:cd17541    1 IRVLIVDDSAVMRKLLSRILESdpdievvGTArdGEEALEkikelkpdviTLDI--------------------EMPVMD 60

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665842216  66 GLNGLISLRNEAPTiPVVIVSA--EEDKQVVLQAITYGACGFITK-SSPRAQMTDAIQQIL 123
Cdd:cd17541   61 GLEALRRIMAERPT-PVVMVSSltEEGAEITLEALELGAVDFIAKpSGGISLDLEEIAEEL 120
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 6-108 5.20e-09

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 52.44  E-value: 5.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   6 KILIADDHPLFREAISSVIASgFAGTEILETDDLDSALEITRENDdldlilldlNMPGMHGLNGLISLRNEAP--TIPVV 83
Cdd:cd17551    2 RILIVDDNPTNLLLLEALLRS-AGYLEVVSFTDPREALAWCRENPpdli-lldyMMPGMDGLEFIRRLRALPGleDVPIV 79

                         90       100
                 ....*....|....*....|....*
gi 665842216  84 IVSAEEDKQVVLQAITYGACGFITK 108
Cdd:cd17551   80 MITADTDREVRLRALEAGATDFLTK 104
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 6-123 5.57e-09

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 52.34  E-value: 5.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   6 KILIADDHPLFREAISSVIAS-GFagTEILETDDLDSALEITRENDDLDLILLDlNMPGMHGLNGLISLRNEA--PTIPV 82
Cdd:cd19923    2 KVLVVDDFSTMRRIIKNLLKElGF--NNVEEAEDGVDALEKLKAGGFDFVITDW-NMPNMDGLELLKTIRADGalSHLPV 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 665842216  83 VIVSAEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQQIL 123
Cdd:cd19923   79 LMVTAEAKKENVIAAAQAGVNNYIVKPFTAATLKEKLEKIF 119
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 7-108 7.04e-09

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 51.86  E-value: 7.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   7 ILIADDHPLFREAISSVIASgfAGTEILETDDLDSALEITRENDDL-DLILLDLNMPGMHGLNGLISLRNEaPTIPVVIV 85
Cdd:cd17584    1 VLVVDDDPTCLAILKRMLLR--CGYQVTTCTDAEEALSMLRENKDEfDLVITDVHMPDMDGFEFLELIRLE-MDLPVIMM 77

                         90       100
                 ....*....|....*....|...
gi 665842216  86 SAEEDKQVVLQAITYGACGFITK 108
Cdd:cd17584   78 SADGSTSTVMKGLAHGACDYLLK 100
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 7-124 9.36e-09

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 51.89  E-value: 9.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   7 ILIADDHPLFREAISSVIASGFAGTEILETDDLDSALEITREnDDLDLILLDLNMPGMHGLNGLISLRNEAPTIPVVIVS 86
Cdd:cd19930    1 VLIAEDQEMVRGALAALLELEDDLEVVAQASNGQEALRLVLK-HSPDVAILDIEMPGRTGLEVAAELREELPDTKVLIVT 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 665842216  87 AEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQQILN 124
Cdd:cd19930   80 TFGRPGYFRRALAAGVDGYVLKDRPIEELADAIRTVHA 117
PRK10100 PRK10100
transcriptional regulator CsgD;
160-216 2.37e-07

transcriptional regulator CsgD;


Pssm-ID: 182241 [Multi-domain]  Cd Length: 216  Bit Score: 49.48  E-value: 2.37e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 665842216 160 LTRRQLLVLERMAKGESNKQIAYNLNIAETTVKAHVSAILRKLGVHNRVQAILSAGD 216
Cdd:PRK10100 156 LTHREKEILNKLRIGASNNEIARSLFISENTVKTHLYNLFKKIAVKNRTQAVSWAND 212
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 60-123 5.83e-07

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 47.10  E-value: 5.83e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665842216  60 NMPGMHGLNGLISLRNEAPTIPVVIVSAEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQQIL 123
Cdd:cd17549   51 RMPGMDGLELLAQIRELDPDLPVILITGHGDVPMAVEAMRAGAYDFLEKPFDPERLLDVVRRAL 114
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 6-122 7.60e-07

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 46.45  E-value: 7.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   6 KILIADDHP----LFREAISSviasgfAGTEILETDDLDSALEITrENDDLDLILLDLNMPGMHGLNGLISLRNEAPTIP 81
Cdd:cd17554    2 KILVVDDEEnireLYKEELED------EGYEVVTAGNGEEALEKL-ESEDPDLVILDIKMPGMDGLETLRKIREKKPDLP 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 665842216  82 VVIVSA-EEDKQvvlQAITYGACGFITKSSPRAQMTDAIQQI 122
Cdd:cd17554   75 VIICTAySEYKS---DFSSWAADAYVVKSSDLTELKETIKRL 113
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 5-123 7.74e-07

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 46.50  E-value: 7.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   5 YKILIADDHPLFREAISSVIASgfAGTEIL-ETDDLDSALEITREnDDLDLILLDLNMPGMHGLNGLISLRNEAPTIPVV 83
Cdd:cd17542    1 KKVLIVDDAAFMRMMLKDILTK--AGYEVVgEAANGEEAVEKYKE-LKPDLVTMDITMPEMDGIEALKEIKKIDPNAKVI 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 665842216  84 IVSAEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQQIL 123
Cdd:cd17542   78 MCSAMGQEEMVKEAIKAGAKDFIVKPFQPERVLEAVEKVL 117
PRK10610 PRK10610
chemotaxis protein CheY;
2-123 9.29e-07

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 46.51  E-value: 9.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   2 DPVYKILIADDHPLFREAISSVIAS-GFAGTEilETDDLDSALEITRENDDLDLILLDlNMPGMHGLNGLISLRNEA--P 78
Cdd:PRK10610   3 DKELKFLVVDDFSTMRRIVRNLLKElGFNNVE--EAEDGVDALNKLQAGGFGFVISDW-NMPNMDGLELLKTIRADGamS 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 665842216  79 TIPVVIVSAEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQQIL 123
Cdd:PRK10610  80 ALPVLMVTAEAKKENIIAAAQAGASGYVVKPFTAATLEEKLNKIF 124
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 6-122 1.14e-06

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 46.26  E-value: 1.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   6 KILIADDHP----LFREAISSviaSGFAgTEILETDDLDSALEITRENDDLDLILLDL------NMPGMHGLNGLISLRN 75
Cdd:cd17557    1 TILLVEDNPgdaeLIQEAFKE---AGVP-NELHVVRDGEEALDFLRGEGEYADAPRPDlilldlNMPRMDGFEVLREIKA 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 665842216  76 EAPT--IPVVIVSAEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQQI 122
Cdd:cd17557   77 DPDLrrIPVVVLTTSDAEEDIERAYELGANSYIVKPVDFEEFVEAIRSL 125
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-108 4.27e-06

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 45.72  E-value: 4.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   1 MDPvYKILIADDHPLFREAISSVIASgfAGTEIL-ETDDLDSALEITREnDDLDLILLDLNMPGMHGLNGLISLRNEAPt 79
Cdd:COG3707    1 MRG-LRVLVVDDEPLRRADLREGLRE--AGYEVVaEAADGEDAVELVRE-LKPDLVIVDIDMPDRDGLEAARQISEERP- 75

                         90       100
                 ....*....|....*....|....*....
gi 665842216  80 IPVVIVSAEEDKQVVLQAITYGACGFITK 108
Cdd:COG3707   76 APVILLTAYSDPELIERALEAGVSAYLVK 104
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 6-108 1.26e-05

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 42.91  E-value: 1.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   6 KILIADDHPLFREAISSVIASgfAGTEILETDDLDSALEITRENDDLDLILLDlNMPGMHGLNGLISLRNEAPT--IPVV 83
Cdd:cd17548    1 KILIVEDNPLNMKLARDLLES--AGYEVLEAADGEEALEIARKEKPDLILMDI-QLPGMDGLEATRLLKEDPATrdIPVI 77

                         90       100
                 ....*....|....*....|....*...
gi 665842216  84 IVSA---EEDKQVVLQAityGACGFITK 108
Cdd:cd17548   78 ALTAyamKGDREKILEA---GCDGYISK 102
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 61-123 1.26e-05

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 42.97  E-value: 1.26e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665842216  61 MPGMHGLNGLISLRNEAPTIPVVIVSAEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQQIL 123
Cdd:cd17537   54 MPGMSGLELQDELLARGSNIPIIFITGHGDVPMAVEAMKAGAVDFLEKPFRDQVLLDAIEQAL 116
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 6-121 1.37e-05

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 42.91  E-value: 1.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   6 KILIADDHPLFREAISSVIaSGFAGTEILETDDLDSALEITRENDDLDLILLDlNMPGMHGLNGLISLRNEAPTIPVVIV 85
Cdd:cd17593    2 KVLICDDSSMARKQLARAL-PADWDVEITFAENGEEALEILREGRIDVLFLDL-TMPVMDGYEVLEALPVEQLETKVIVV 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 665842216  86 SAEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQQ 121
Cdd:cd17593   80 SGDVQPEAKERVLELGALAFLKKPFDPEKLAQLLEE 115
PRK11475 PRK11475
DNA-binding transcriptional activator BglJ; Provisional
 68-217 2.00e-05

DNA-binding transcriptional activator BglJ; Provisional


Pssm-ID: 236915 [Multi-domain]  Cd Length: 207  Bit Score: 43.96  E-value: 2.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216  68 NGLISLRNEAPTIPVV--IVSAEEDKQVVLQAITYGAC--GFITKSSPRAQMTDAIQQILNGnvylpsdiIRTGKESSQR 143
Cdd:PRK11475  54 EGLSCLTELAIKFPRMrrLVIADDDIEARLIGSLSPSPldGVLSKASTLEILQQELFLSLNG--------VRQATDRLNN 125

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665842216 144 RVRSDEN-PISPellnslTRRQllVLERMAKGESNKQIAYNLNIAETTVKAHVSAILRKLGVHNRVqAILSAGDV 217
Cdd:PRK11475 126 QWYINQSrMLSP------TERE--ILRFMSRGYSMPQIAEQLERNIKTIRAHKFNVMSKLGVSSDA-GLLDAADI 191
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 5-124 2.93e-05

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 43.65  E-value: 2.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   5 YKILIADDHPLFREAISSVIASgFAGTEIL-ETDDLDSALEITRENDdldlilldLNMPGMHGLNGLISLRNEAPTIPVV 83
Cdd:COG3279    2 MKILIVDDEPLARERLERLLEK-YPDLEVVgEASNGEEALELLEEHKpdlv-fldIQMPGLDGFELARQLRELDPPPPII 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 665842216  84 IVSAeeDKQVVLQAITYGACGFITKSSPRAQMTDAIQQILN 124
Cdd:COG3279   80 FTTA--YDEYALEAFEVNAVDYLLKPIDEERLAKALEKAKE 118
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
1-108 4.54e-05

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 43.68  E-value: 4.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   1 MDPVYKILIADDHPLFREAISSVIAsgFAGTEILETDDLDSALEITREnDDLDLILLDLNMPGMHGLNGLISLRNEAPTI 80
Cdd:PRK11361   1 MTAINRILIVDDEDNVRRMLSTAFA--LQGFETHCANNGRTALHLFAD-IHPDVVLMDIRMPEMDGIKALKEMRSHETRT 77

                         90       100
                 ....*....|....*....|....*...
gi 665842216  81 PVVIVSAEEDKQVVLQAITYGACGFITK 108
Cdd:PRK11361  78 PVILMTAYAEVETAVEALRCGAFDYVIK 105
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 6-108 4.68e-05

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 41.33  E-value: 4.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   6 KILIADDHPLFREAISSVIASgfAGTEILETDDLDSALEITRENDDLDLILLDlNMPGMHGLNGLISLRNEAPT--IPVV 83
Cdd:cd17538    1 KILVVDDEPANRELLEALLSA--EGYEVLTADSGQEALALAEEELPDLILLDV-MMPGMDGFEVCRRLKEDPETrhIPVI 77

                         90       100
                 ....*....|....*....|....*
gi 665842216  84 IVSAEEDKQVVLQAITYGACGFITK 108
Cdd:cd17538   78 MITALDDREDRIRGLEAGADDFLSK 102
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 6-108 6.01e-05

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 41.18  E-value: 6.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   6 KILIADDHPLFREAISsvIASGFAGTEILETDDLDSALEITRENDDLDLILLDLnMPGMHGLNGLISLRNEAPTIPVVIV 85
Cdd:cd17615    1 RVLVVDDEPNITELLS--MALRYEGWDVETAADGAEALAAAREFRPDAVVLDIM-LPDMDGLEVLRRLRADGPDVPVLFL 77

                         90       100
                 ....*....|....*....|...
gi 665842216  86 SAEEDKQVVLQAITYGACGFITK 108
Cdd:cd17615   78 TAKDSVEDRIAGLTAGGDDYVTK 100
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 6-124 6.11e-05

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 41.25  E-value: 6.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   6 KILIADDHPLFREAISSVIASgfAGTEIL-ETDDLDSALEITREnDDLDLILLDLNMPGMHGLNGLISLRNEAPTiPVVI 84
Cdd:cd19932    2 RVLIAEDEALIRMDLREMLEE--AGYEVVgEASDGEEAVELAKK-HKPDLVIMDVKMPRLDGIEAAKIITSENIA-PIVL 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 665842216  85 VSAEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQQILN 124
Cdd:cd19932   78 LTAYSQQDLVERAKEAGAMAYLVKPFSESDLIPAIEMAIA 117
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
6-215 1.04e-04

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 42.01  E-value: 1.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   6 KILIADDHPLFREAISSVIASGfaGTEILETDDLDSALEITREnDDLDLILLDLNMPGMHGLNGLISLRNEAPT--IPVV 83
Cdd:PRK10161   4 RILVVEDEAPIREMVCFVLEQN--GFQPVEAEDYDSAVNQLNE-PWPDLILLDWMLPGGSGIQFIKHLKRESMTrdIPVV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216  84 IVSAEEDKQVVLQAITYGACGFITKS-SPR---AQMTDAIQQILNGNVYLPSDIIRTGKESSQRRVRSDENPIS------ 153
Cdd:PRK10161  81 MLTARGEEEDRVRGLETGADDYITKPfSPKelvARIKAVMRRISPMAVEEVIEMQGLSLDPTSHRVMAGEEPLEmgptef 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665842216 154 ---------PELLNSltRRQLLvlermakgesNKQIAYNLNIAETTVKAHVSAILRKL--GVHNR-VQAILSAG 215
Cdd:PRK10161 161 kllhffmthPERVYS--REQLL----------NHVWGTNVYVEDRTVDVHIRRLRKALepGGHDRmVQTVRGTG 222
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 6-112 1.33e-04

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 40.31  E-value: 1.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   6 KILIADDHPLFREAISSVIASgfAGTEILETDDLDSALEITREnDDLDLILLDLNMPGMHGLNGLISLRNEAPT--IPVV 83
Cdd:cd17618    2 TILIVEDEPAIREMIAFNLER--AGFDVVEAEDAESAVNLIVE-PRPDLILLDWMLPGGSGIQFIRRLKRDEMTrdIPII 78

                         90       100       110
                 ....*....|....*....|....*....|...
gi 665842216  84 IVSA---EEDKQVVLQAityGACGFITKS-SPR 112
Cdd:cd17618   79 MLTArgeEEDKVRGLEA---GADDYITKPfSPR 108
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
1-147 1.57e-04

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 41.67  E-value: 1.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   1 MDPVyKILIADDHPLFREAISSVIAS-------GFAGT-----EILETDDLDSA-LEItrenddldlilldlNMPGMHGL 67
Cdd:PRK00742   1 MMKI-RVLVVDDSAFMRRLISEILNSdpdievvGTAPDglearEKIKKLNPDVItLDV--------------EMPVMDGL 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216  68 NGLISLRNEAPTiPVVIVSA--EEDKQVVLQAITYGACGFITK--SSPRAQMTDAIQQILngnvylpsDIIRTgkeSSQR 143
Cdd:PRK00742  66 DALEKIMRLRPT-PVVMVSSltERGAEITLRALELGAVDFVTKpfLGISLGMDEYKEELA--------EKVRA---AARA 133


                 ....
gi 665842216 144 RVRS 147
Cdd:PRK00742 134 RVRA 137
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 6-123 1.68e-04

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 39.98  E-value: 1.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   6 KILIADDHPLFREAISSVIASgfAGTEILETDDLDSALEITrENDDLDLILLDLNMPGMHGLnGLI-SLRNEA--PTIPV 82
Cdd:cd17562    2 KILAVDDSASIRQMVSFTLRG--AGYEVVEAADGRDALSKA-QSKKFDLIITDQNMPNMDGI-ELIkELRKLPayKFTPI 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 665842216  83 VIVSAEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQQIL 123
Cdd:cd17562   78 LMLTTESSDEKKQEGKAAGATGWLVKPFDPEQLLEVVKKVL 118
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 6-108 5.13e-04

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 40.62  E-value: 5.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   6 KILIADDHPLFREAISSVIASgfAGTEILETDDLDSALEITRENDDLDLILLDlNMPGMHGLNGLISLRNEAPTIPVVIV 85
Cdd:PRK10923   5 IVWVVDDDSSIRWVLERALAG--AGLTCTTFENGNEVLEALASKTPDVLLSDI-RMPGMDGLALLKQIKQRHPMLPVIIM 81

                         90       100
                 ....*....|....*....|...
gi 665842216  86 SAEEDKQVVLQAITYGACGFITK 108
Cdd:PRK10923  82 TAHSDLDAAVSAYQQGAFDYLPK 104
Sigma70_r4_2 pfam08281
Sigma-70, region 4; Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 ...
 155-202 8.64e-04

Sigma-70, region 4; Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 promoter element via a helix-turn-helix motif.


Pssm-ID: 400535 [Multi-domain]  Cd Length: 54  Bit Score: 36.28  E-value: 8.64e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 665842216  155 ELLNSLTRRQLLVLE-RMAKGESNKQIAYNLNIAETTVKAHVSAILRKL 202
Cdd:pfam08281   6 RALEELPPRQREVFLlRYLEGLSYAEIAELLGISEGTVKSRLSRARKKL 54
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 5-121 1.11e-03

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 37.61  E-value: 1.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   5 YKILIADDHPLFREAISSVIA--SGFagTEILETDDLDSALEITREnDDLDLILLDLNMPGMHGLNGLISLRNEAPTIPV 82
Cdd:cd19925    1 INVLIVEDDPMVAEIHRAYVEqvPGF--TVIGTAGTGEEALKLLKE-RQPDLILLDIYLPDGNGLDLLRELRAAGHDVDV 77

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 665842216  83 VIVSAEEDKQVVLQAITYGACGFITKSSPRAQMTDAIQQ 121
Cdd:cd19925   78 IVVTAANDVETVREALRLGVVDYLIKPFTFERLRQRLER 116
RpoE COG1595
DNA-directed RNA polymerase specialized sigma subunit, sigma24 family [Transcription]; ...
 155-202 1.30e-03

DNA-directed RNA polymerase specialized sigma subunit, sigma24 family [Transcription]; DNA-directed RNA polymerase specialized sigma subunit, sigma24 family is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 441203 [Multi-domain]  Cd Length: 181  Bit Score: 38.44  E-value: 1.30e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 665842216 155 ELLNSLTRRQLLVLE-RMAKGESNKQIAYNLNIAETTVKAHVSAILRKL 202
Cdd:COG1595  123 AALERLPPRQREVLVlRYLEGLSYAEIAEILGISEGTVKSRLSRARKKL 171
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 8-108 1.93e-03

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 36.62  E-value: 1.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   8 LIADDHPLFREAISSVIASgfAGTEILETDDLDSALEITRENDdldlilldLNMPGMHGLNGLISLRNEAPTIPVVIVSA 87
Cdd:cd17574    1 LVVEDDEEIAELLSDYLEK--EGYEVDTAADGEEALELAREEQpdli-ildVMLPGMDGFEVCRRLREKGSDIPIIMLTA 77

                         90       100
                 ....*....|....*....|.
gi 665842216  88 EEDKQVVLQAITYGACGFITK 108
Cdd:cd17574   78 KDEEEDKVLGLELGADDYITK 98
PRK12555 PRK12555
chemotaxis-specific protein-glutamate methyltransferase CheB;
6-108 3.09e-03

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 237135 [Multi-domain]  Cd Length: 337  Bit Score: 37.94  E-value: 3.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   6 KILIADDHPLFREAISSVIASGfAGTEIL--ETDDLDSALEITRENDDLDLILLdlNMPGMHGLNGLISLRNEAPTiPVV 83
Cdd:PRK12555   2 RIGIVNDSPLAVEALRRALARD-PDHEVVwvATDGAQAVERCAAQPPDVILMDL--EMPRMDGVEATRRIMAERPC-PIL 77

                         90       100
                 ....*....|....*....|....*..
gi 665842216  84 IVSA--EEDKQVVLQAITYGACGFITK 108
Cdd:PRK12555  78 IVTSltERNASRVFEAMGAGALDAVDT 104
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 5-49 3.44e-03

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 34.85  E-value: 3.44e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 665842216     5 YKILIADDHPLFREAISSVIASgfAGTEILETDDLDSALEITREN 49
Cdd:smart00448   1 MRILVVDDDPLLRELLKALLEK--EGYEVDEATDGEEALELLKEE 43
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 61-108 5.71e-03

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 35.71  E-value: 5.71e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 665842216  61 MPGMHGLNGLISLRNEAPTIPVVIVSAEEDKQVVLQAITYGACGFITK 108
Cdd:cd19919   54 MPGMDGLALLAQIKQRHPDLPVIIMTAHSDLDSAVSAYQGGAFEYLPK 101
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 6-108 6.75e-03

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 35.57  E-value: 6.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665842216   6 KILIADDHPLFREAISSVIAS-GFagtEILETDDLDSALEITRENDDLDLILLDLNMPGMHGLNGLISLRNEAPTIPVVI 84
Cdd:cd17544    2 KVLVVDDSATSRNHLRALLRRhNF---QVLEAANGQEALEVLEQHPDIKLVITDYNMPEMDGFELVREIRKKYSRDQLAI 78

                         90       100
                 ....*....|....*....|....*.
gi 665842216  85 --VSAEEDKQVVLQAITYGACGFITK 108
Cdd:cd17544   79 igISASGDNALSARFIKAGANDFLTK 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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