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Conserved domains on  [gi|665866672|ref|WP_031233879|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [Agrobacterium tumefaciens complex]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 11454538)

AraC family transcriptional regulator containing an AraC family helix-turn-helix (HTH) DNA-binding domain, may regulate the expression of genes with diverse biological functions including metabolism, stress response, and virulence

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
HTH_18 pfam12833
Helix-turn-helix domain;
215-293 6.07e-18

Helix-turn-helix domain;


:

Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 76.86  E-value: 6.07e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665866672  215 VAKELGISLRQLHVVFEGAE-LSFSRTLSSMRIEEAKRLLLAFPALPVTQIAYGCGFDSLATFYRVFAGTYGMTPGDARA 293
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELgLSPKEYLRRLRLERARRLLLEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
69-294 8.25e-16

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


:

Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 75.59  E-value: 8.25e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665866672  69 SGFLHAGRDQVHAVGGGDITINYSDLPYDAIPGNEADFHYKMLKIPVDYEVMLGQATDDLFATRYAENNSFALPFRALFN 148
Cdd:COG2207   40 LLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLL 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665866672 149 ALNAAPGRLIDPARDVTHIARLAMTARGRLSPAMPEVRAALRTGLCYAAqdimirkksrqnLTPAAVAKELGISLRQLHV 228
Cdd:COG2207  120 LLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL------------LTLEELARELGLSPRTLSR 187
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665866672 229 VF-EGAELSFSRTLSSMRIEEAKRLLLAfPALPVTQIAYGCGFDSLATFYRVFAGTYGMTPGDARAE 294
Cdd:COG2207  188 LFkEETGTSPKQYLRELRLERAKRLLAE-TDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKR 253
 
Name Accession Description Interval E-value
HTH_18 pfam12833
Helix-turn-helix domain;
215-293 6.07e-18

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 76.86  E-value: 6.07e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665866672  215 VAKELGISLRQLHVVFEGAE-LSFSRTLSSMRIEEAKRLLLAFPALPVTQIAYGCGFDSLATFYRVFAGTYGMTPGDARA 293
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELgLSPKEYLRRLRLERARRLLLEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
209-292 6.89e-18

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 76.82  E-value: 6.89e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665866672   209 NLTPAAVAKELGISLRQLHVVFEGAE-LSFSRTLSSMRIEEAKRLLlAFPALPVTQIAYGCGFDSLATFYRVFAGTYGMT 287
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETgTTPKQYLRDRRLERARRLL-RDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVT 79

                   ....*
gi 665866672   288 PGDAR 292
Cdd:smart00342  80 PSEYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
69-294 8.25e-16

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 75.59  E-value: 8.25e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665866672  69 SGFLHAGRDQVHAVGGGDITINYSDLPYDAIPGNEADFHYKMLKIPVDYEVMLGQATDDLFATRYAENNSFALPFRALFN 148
Cdd:COG2207   40 LLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLL 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665866672 149 ALNAAPGRLIDPARDVTHIARLAMTARGRLSPAMPEVRAALRTGLCYAAqdimirkksrqnLTPAAVAKELGISLRQLHV 228
Cdd:COG2207  120 LLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL------------LTLEELARELGLSPRTLSR 187
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665866672 229 VF-EGAELSFSRTLSSMRIEEAKRLLLAfPALPVTQIAYGCGFDSLATFYRVFAGTYGMTPGDARAE 294
Cdd:COG2207  188 LFkEETGTSPKQYLRELRLERAKRLLAE-TDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKR 253
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
196-293 1.38e-12

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 66.72  E-value: 1.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665866672 196 AAQDIMiRKKSRQNLTPAAVAKELGISLRQLHVVFEgAEL--SFSRTLSSMRIEEAKRLLLAfPALPVTQIAYGCGFDSL 273
Cdd:COG4977  214 RAQAWM-EANLEEPLSVDELARRAGMSPRTLERRFR-AATgtTPARYLQRLRLERARRLLET-TDLSIEEIAAACGFGSA 290
                         90       100
                 ....*....|....*....|
gi 665866672 274 ATFYRVFAGTYGMTPGDARA 293
Cdd:COG4977  291 SHFRRAFRRRFGVSPSAYRR 310
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
209-293 8.08e-10

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 58.50  E-value: 8.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665866672 209 NLTPAAVAKELGISLRQLHVVFEGAELSFSRTLSSMRIEEAKRLLLAFPA-LPVTQIAYGCGFDSLATFYRVFAGTYGMT 287
Cdd:PRK09685 214 ILRPEWIAGELGISVRSLYRLFAEQGLVVAQYIRNRRLDRCADDLRPAADdEKITSIAYKWGFSDSSHFSTAFKQRFGVS 293

                 ....*.
gi 665866672 288 PGDARA 293
Cdd:PRK09685 294 PGEYRR 299
AraC_binding pfam02311
AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization ...
60-171 4.41e-08

AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH) DNA-binding motif pfam00165. This domain is distantly related to the Cupin domain pfam00190.


Pssm-ID: 396749 [Multi-domain]  Cd Length: 134  Bit Score: 50.90  E-value: 4.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665866672   60 LCIGLQVKGSGFLHAGrDQVHAVGGGDITINYSDLPYDAIPGNEADFHYKMLKIPVDyevMLGQATDDLFATRYA----- 134
Cdd:pfam02311  24 YVIGYIERGVGRFRLN-GRTYHLGPGDLFLLPPGEPHDYEPESEDGWRYRWLYFEPE---LLERILADISILAGGplpll 99
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 665866672  135 ENNSFALPFRALFNALNAApgRLIDPARDVTHIARLA 171
Cdd:pfam02311 100 RDPELAALLRALFRLLEEA--GRSDDLLAEALLYQLL 134
 
Name Accession Description Interval E-value
HTH_18 pfam12833
Helix-turn-helix domain;
215-293 6.07e-18

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 76.86  E-value: 6.07e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665866672  215 VAKELGISLRQLHVVFEGAE-LSFSRTLSSMRIEEAKRLLLAFPALPVTQIAYGCGFDSLATFYRVFAGTYGMTPGDARA 293
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELgLSPKEYLRRLRLERARRLLLEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
209-292 6.89e-18

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 76.82  E-value: 6.89e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665866672   209 NLTPAAVAKELGISLRQLHVVFEGAE-LSFSRTLSSMRIEEAKRLLlAFPALPVTQIAYGCGFDSLATFYRVFAGTYGMT 287
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETgTTPKQYLRDRRLERARRLL-RDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVT 79

                   ....*
gi 665866672   288 PGDAR 292
Cdd:smart00342  80 PSEYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
69-294 8.25e-16

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 75.59  E-value: 8.25e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665866672  69 SGFLHAGRDQVHAVGGGDITINYSDLPYDAIPGNEADFHYKMLKIPVDYEVMLGQATDDLFATRYAENNSFALPFRALFN 148
Cdd:COG2207   40 LLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLL 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665866672 149 ALNAAPGRLIDPARDVTHIARLAMTARGRLSPAMPEVRAALRTGLCYAAqdimirkksrqnLTPAAVAKELGISLRQLHV 228
Cdd:COG2207  120 LLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL------------LTLEELARELGLSPRTLSR 187
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665866672 229 VF-EGAELSFSRTLSSMRIEEAKRLLLAfPALPVTQIAYGCGFDSLATFYRVFAGTYGMTPGDARAE 294
Cdd:COG2207  188 LFkEETGTSPKQYLRELRLERAKRLLAE-TDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKR 253
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
196-293 1.38e-12

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 66.72  E-value: 1.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665866672 196 AAQDIMiRKKSRQNLTPAAVAKELGISLRQLHVVFEgAEL--SFSRTLSSMRIEEAKRLLLAfPALPVTQIAYGCGFDSL 273
Cdd:COG4977  214 RAQAWM-EANLEEPLSVDELARRAGMSPRTLERRFR-AATgtTPARYLQRLRLERARRLLET-TDLSIEEIAAACGFGSA 290
                         90       100
                 ....*....|....*....|
gi 665866672 274 ATFYRVFAGTYGMTPGDARA 293
Cdd:COG4977  291 SHFRRAFRRRFGVSPSAYRR 310
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
201-293 3.98e-11

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 62.76  E-value: 3.98e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665866672 201 MIRKKSRQNLTPAAVAKELGISLRQLHVVFEgAEL--SFSRTLSSMRIEEAKRLLLAfpALPVTQIAYGCGFDSLATFYR 278
Cdd:COG2169   92 LIEAGAEDRPSLEDLAARLGLSPRHLRRLFK-AHTgvTPKAYARARRLLRARQLLQT--GLSVTDAAYAAGFGSLSRFYE 168
                         90
                 ....*....|....*
gi 665866672 279 VFAGTYGMTPGDARA 293
Cdd:COG2169  169 AFKKLLGMTPSAYRR 183
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
209-293 8.08e-10

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 58.50  E-value: 8.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665866672 209 NLTPAAVAKELGISLRQLHVVFEGAELSFSRTLSSMRIEEAKRLLLAFPA-LPVTQIAYGCGFDSLATFYRVFAGTYGMT 287
Cdd:PRK09685 214 ILRPEWIAGELGISVRSLYRLFAEQGLVVAQYIRNRRLDRCADDLRPAADdEKITSIAYKWGFSDSSHFSTAFKQRFGVS 293

                 ....*.
gi 665866672 288 PGDARA 293
Cdd:PRK09685 294 PGEYRR 299
AraC_binding pfam02311
AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization ...
60-171 4.41e-08

AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH) DNA-binding motif pfam00165. This domain is distantly related to the Cupin domain pfam00190.


Pssm-ID: 396749 [Multi-domain]  Cd Length: 134  Bit Score: 50.90  E-value: 4.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665866672   60 LCIGLQVKGSGFLHAGrDQVHAVGGGDITINYSDLPYDAIPGNEADFHYKMLKIPVDyevMLGQATDDLFATRYA----- 134
Cdd:pfam02311  24 YVIGYIERGVGRFRLN-GRTYHLGPGDLFLLPPGEPHDYEPESEDGWRYRWLYFEPE---LLERILADISILAGGplpll 99
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 665866672  135 ENNSFALPFRALFNALNAApgRLIDPARDVTHIARLA 171
Cdd:pfam02311 100 RDPELAALLRALFRLLEEA--GRSDDLLAEALLYQLL 134
ftrA PRK09393
transcriptional activator FtrA; Provisional
175-293 1.81e-05

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 45.34  E-value: 1.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665866672 175 RGRLSPAMPEVRAALRtglcyaaqdimirkksrQNLTPAAVAKELGISLRQLHVVFEGAE-LSFSRTLSSMRIEEAKRLL 253
Cdd:PRK09393 217 SDRLGPLIDWMRAHLA-----------------EPHTVASLAARAAMSPRTFLRRFEAATgMTPAEWLLRERLARARDLL 279
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 665866672 254 LAfPALPVTQIAYGCGFDSLATFYRVFAGTYGMTPGDARA 293
Cdd:PRK09393 280 ES-SALSIDQIAERAGFGSEESLRHHFRRRAATSPAAYRK 318
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
211-297 2.69e-05

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 44.92  E-value: 2.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665866672 211 TPAAVAKELGISLRQLHVVFEGAELSFSRTLSSMRIEEAKRLLLAFpALPVTQIAYGCGFDSLATFYRVFAGTYGMTPG- 289
Cdd:PRK09978 160 TLARIASELLMSPSLLKKKLREEETSYSQLLTECRMQRALQLIVIH-GFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTe 238
                         90
                 ....*....|
gi 665866672 290 --DARAEDMP 297
Cdd:PRK09978 239 yqERSAQGLP 248
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
208-292 9.55e-04

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 37.98  E-value: 9.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665866672 208 QNLTPAAVAKELGISLRQLHVVFEGAelsFSRTLSSMrIEEaKRLLLAFPAL-----PVTQIAYGCGFDSLATFYRVFAG 282
Cdd:PRK10219  20 QPLNIDVVAKKSGYSKWYLQRMFRTV---THQTLGDY-IRQ-RRLLLAAVELrtterPIFDIAMDLGYVSQQTFSRVFRR 94
                         90
                 ....*....|
gi 665866672 283 TYGMTPGDAR 292
Cdd:PRK10219  95 QFDRTPSDYR 104
PRK15044 PRK15044
transcriptional regulator SirC; Provisional
199-288 1.97e-03

transcriptional regulator SirC; Provisional


Pssm-ID: 185004 [Multi-domain]  Cd Length: 295  Bit Score: 39.25  E-value: 1.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665866672 199 DIMIRKKSRQnLTPAAVAKELGISLRQLHVVFEGAELSFSRTLSSMRIEEAKRLLlAFPALPVTQIAYGCGFDSLATFYR 278
Cdd:PRK15044 199 NIIISDLTRK-WSQAEVAGKLFMSVSSLKRKLAAEEVSFSKIYLDARMNQAIKLL-RMGAGNISQVATMCGYDTPSYFIA 276
                         90
                 ....*....|
gi 665866672 279 VFAGTYGMTP 288
Cdd:PRK15044 277 IFKRHFKITP 286
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
199-290 5.98e-03

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 37.74  E-value: 5.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665866672 199 DIMIRKKSRQnLTPAAVAKELGISLRQLHVVFEGAELSFSRTLSSMRIEEAKRLLLAfPALPVTQIAYGCGFDSLATFYR 278
Cdd:PRK15186 188 NIIISDISRK-WALKDISDSLYMSCSTLKRKLKQENTSFSEVYLNARMNKATKLLRN-SEYNITRVAYMCGYDSASYFTC 265
                         90
                 ....*....|..
gi 665866672 279 VFAGTYGMTPGD 290
Cdd:PRK15186 266 VFKKHFKTTPSE 277
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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