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Conserved domains on  [gi|665923365|ref|WP_031289416|]
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MULTISPECIES: Lrp/AsnC family transcriptional regulator [Pseudoalteromonas]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-136 2.13e-33

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 114.11  E-value: 2.13e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665923365   1 MITSQDEKLLSILKTNARASISDLARMLNLSRSTVQSRMLKLEETGVIKGYSVDYGEDYLTSMVSAHVSIKVMQKLTTKT 80
Cdd:COG1522    2 ELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDEF 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 665923365  81 NLELKQIDAISQLYAISGEFDLIAVVQAQNLEKLSHLLDD-IGNLDGVERTTSSVIL 136
Cdd:COG1522   82 AEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLErLAALPGVRRTETSFVL 138
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-136 2.13e-33

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 114.11  E-value: 2.13e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665923365   1 MITSQDEKLLSILKTNARASISDLARMLNLSRSTVQSRMLKLEETGVIKGYSVDYGEDYLTSMVSAHVSIKVMQKLTTKT 80
Cdd:COG1522    2 ELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDEF 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 665923365  81 NLELKQIDAISQLYAISGEFDLIAVVQAQNLEKLSHLLDD-IGNLDGVERTTSSVIL 136
Cdd:COG1522   82 AEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLErLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 6-108 4.61e-19

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 76.40  E-value: 4.61e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665923365     6 DEKLLSILKTNARASISDLARMLNLSRSTVQSRMLKLEETGVIKGYSVDYGEDYLTSMVSAHVSIKV-MQKLTTKTNLEL 84
Cdd:smart00344   5 DRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLeNPDKLEEFLEKL 84

                           90       100
                   ....*....|....*....|....
gi 665923365    85 KQIDAISQLYAISGEFDLIAVVQA 108
Cdd:smart00344  85 EKLPEVEEVYLVTGDYDYLLKVRA 108
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 83-138 5.53e-12

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 57.15  E-value: 5.53e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 665923365   83 ELKQIDAISQLYAISGEFDLIAVVQAQNLEKLSHLLDD-IGNLDGVERTTSSVILET 138
Cdd:pfam01037  17 ALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREkLRSLPGVARTETSIVLST 73
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
6-137 2.62e-06

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 44.37  E-value: 2.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665923365   6 DEKLLSILKTNARASISDLARMLNLSRSTVQSRMLKLEETGVIKGYSVDYGEDYLTSMVSAHVSIKVMQ---KLTTKTNL 82
Cdd:PRK11169  16 DRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRgapDVFEQFNA 95

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 665923365  83 ELKQIDAISQLYAISGEFDLIAVVQAQNLEKLSHLL-DDIGNLDGVERTTSSVILE 137
Cdd:PRK11169  96 AVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLgETLLRLPGVNDTRTYVVME 151
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 8-51 2.34e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 34.97  E-value: 2.34e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 665923365   8 KLLSILKTNaRASISDLARMLNLSRSTVQSRMLKLEETGVIKGY 51
Cdd:cd00090   11 RILRLLLEG-PLTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 2-49 8.29e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 35.02  E-value: 8.29e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 665923365    2 ITSQDEKLLSILKTNARASISDLARMLNLSRSTVQSRMLKLEETGVIK 49
Cdd:TIGR01884 141 LSREELKILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVE 188
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-136 2.13e-33

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 114.11  E-value: 2.13e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665923365   1 MITSQDEKLLSILKTNARASISDLARMLNLSRSTVQSRMLKLEETGVIKGYSVDYGEDYLTSMVSAHVSIKVMQKLTTKT 80
Cdd:COG1522    2 ELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDEF 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 665923365  81 NLELKQIDAISQLYAISGEFDLIAVVQAQNLEKLSHLLDD-IGNLDGVERTTSSVIL 136
Cdd:COG1522   82 AEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLErLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 6-108 4.61e-19

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 76.40  E-value: 4.61e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665923365     6 DEKLLSILKTNARASISDLARMLNLSRSTVQSRMLKLEETGVIKGYSVDYGEDYLTSMVSAHVSIKV-MQKLTTKTNLEL 84
Cdd:smart00344   5 DRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLeNPDKLEEFLEKL 84

                           90       100
                   ....*....|....*....|....
gi 665923365    85 KQIDAISQLYAISGEFDLIAVVQA 108
Cdd:smart00344  85 EKLPEVEEVYLVTGDYDYLLKVRA 108
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 83-138 5.53e-12

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 57.15  E-value: 5.53e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 665923365   83 ELKQIDAISQLYAISGEFDLIAVVQAQNLEKLSHLLDD-IGNLDGVERTTSSVILET 138
Cdd:pfam01037  17 ALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREkLRSLPGVARTETSIVLST 73
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
6-43 6.67e-11

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 53.53  E-value: 6.67e-11
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 665923365    6 DEKLLSILKTNARASISDLARMLNLSRSTVQSRMLKLE 43
Cdd:pfam13404   4 DRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
6-48 1.91e-09

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 50.12  E-value: 1.91e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 665923365    6 DEKLLSILKTNARASISDLARMLNLSRSTVQSRMLKLEETGVI 48
Cdd:pfam13412   3 DRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
6-137 2.62e-06

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 44.37  E-value: 2.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665923365   6 DEKLLSILKTNARASISDLARMLNLSRSTVQSRMLKLEETGVIKGYSVDYGEDYLTSMVSAHVSIKVMQ---KLTTKTNL 82
Cdd:PRK11169  16 DRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRgapDVFEQFNA 95

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 665923365  83 ELKQIDAISQLYAISGEFDLIAVVQAQNLEKLSHLL-DDIGNLDGVERTTSSVILE 137
Cdd:PRK11169  96 AVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLgETLLRLPGVNDTRTYVVME 151
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 2-130 3.20e-06

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 43.93  E-value: 3.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665923365   2 ITSQDEKLLSILKTNARASISDLARMLNLSRSTVQSRMLKLEETGVIKGYSVDYGEDYLTSMVSAHVSI-----KVMQKL 76
Cdd:PRK11179   7 IDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIilksaKDYPSA 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 665923365  77 TTKtnleLKQIDAISQLYAISGEFDLIAVVQAQNLEKLSHLL-DDIGNLDGVERT 130
Cdd:PRK11179  87 LAK----LESLDEVVEAYYTTGHYSIFIKVMCRSIDALQHVLiNKIQTIDEIQST 137
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
2-48 2.62e-04

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 37.96  E-value: 2.62e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 665923365     2 ITSQDEKLLSILKTNARASISDLARMLNLSRSTVqSRMLK-LEETGVI 48
Cdd:smart00347   8 LTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTV-TRVLDrLEKKGLV 54
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
3-48 5.02e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 38.37  E-value: 5.02e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 665923365   3 TSQDEKLLSILKTNARASISDLARMLNLSRSTVQSRMLKLEETGVI 48
Cdd:COG2345   12 DPTRRRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLV 57
COG3888 COG3888
Predicted transcriptional regulator [Transcription];
6-49 6.36e-04

Predicted transcriptional regulator [Transcription];


Pssm-ID: 443096 [Multi-domain]  Cd Length: 328  Bit Score: 38.46  E-value: 6.36e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 665923365   6 DEKLLSILKTNARASI--SDLARMLNLSRSTVQSRMLKLEETGVIK 49
Cdd:COG3888    5 REKILRILKNYGGEGIpqSELVRLLGASKSRVSEILSELEKEGLIA 50
BirA COG1654
Biotin operon repressor [Transcription];
1-51 7.56e-04

Biotin operon repressor [Transcription];


Pssm-ID: 441260 [Multi-domain]  Cd Length: 324  Bit Score: 38.04  E-value: 7.56e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 665923365   1 MITSQDEKLLSILKTNARASISDLARMLNLSRSTVQSRMLKLEETGVI------KGY 51
Cdd:COG1654    1 MMSSTRLKLLRLLADGEFHSGEELAEELGVSRAAVWKHIKALRELGYEiesvpgKGY 57
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
7-54 8.56e-04

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 37.17  E-value: 8.56e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 665923365   7 EKLLSILKTNARASISDLARMLNLSRSTVQSRMLKLEETGVIKGYSVD 54
Cdd:COG3398   24 RRIYEYIRENPGIHFREIVRDLGLNRGTLRYHLRRLEREGKITSEKDG 71
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
7-81 8.69e-04

DNA-binding transcriptional regulator, IclR family [Transcription];


Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 37.88  E-value: 8.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665923365   7 EKLLSILK----TNARASISDLARMLNLSRSTVqSRMLK-LEETGVI------KGYS-----VDYGEDYLTSMVSAHVSI 70
Cdd:COG1414    9 ERALAILEalaeAGGGLSLSELARRLGLPKSTV-HRLLAtLEEEGYVerdpegGRYRlgprlLELGSAALRRLDLRRLAR 87

                         90
                 ....*....|.
gi 665923365  71 KVMQKLTTKTN 81
Cdd:COG1414   88 PVLEELAEETG 98
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
8-55 9.45e-04

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 37.17  E-value: 9.45e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 665923365   8 KLLSILKTNARASISDLARMLNLSRSTVQSRMLKLEETGVIK----GYSVDY 55
Cdd:COG3398  101 RILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVErerdGRNVRY 152
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
8-49 9.48e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 36.48  E-value: 9.48e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 665923365   8 KLLSILKTNARaSISDLARMLNLSRSTVQSRMLKLEETGVIK 49
Cdd:COG4189   23 RILRLLAEEPL-NVNELAEALGLPKSTVSYHIRKLEEAGLIR 63
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 2-49 1.96e-03

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 34.89  E-value: 1.96e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 665923365   2 ITSQDEKLLSILKTNA-RASISDLARMLNLSRSTVqSRML-KLEETGVIK 49
Cdd:COG2512   13 LLEDERRVLELLRENGgRMTQSEIVKETGWSKSKV-SRLLsRLEERGLIE 61
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 8-51 2.34e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 34.97  E-value: 2.34e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 665923365   8 KLLSILKTNaRASISDLARMLNLSRSTVQSRMLKLEETGVIKGY 51
Cdd:cd00090   11 RILRLLLEG-PLTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
7-49 2.40e-03

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 35.95  E-value: 2.40e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 665923365   7 EKLLSILKTNARASISDLARMLNLSRSTVqSRML-KLEETGVIK 49
Cdd:COG1321   13 KAIYELSEEGGPVRTSDIAERLGVSPPSV-TEMLkKLEEKGLVE 55
CasRa_I-A cd09655
CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly ...
 2-49 3.40e-03

CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Predicted transcriptional regulator of CRISPR/Cas system


Pssm-ID: 187786 [Multi-domain]  Cd Length: 198  Bit Score: 35.82  E-value: 3.40e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 665923365   2 ITSQDEKLLSILKTNARASISDLARMLNLSRSTVQSRMLKLEETGVIK 49
Cdd:cd09655  137 LSREELKILEVLKAKGEKSVKNIAKKLGKSLSTISRHLRELEKKGLVE 184
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 2-49 8.29e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 35.02  E-value: 8.29e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 665923365    2 ITSQDEKLLSILKTNARASISDLARMLNLSRSTVQSRMLKLEETGVIK 49
Cdd:TIGR01884 141 LSREELKILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVE 188
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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