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Conserved domains on  [gi|671551522|ref|WP_031534199|]
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MULTISPECIES: TrkA family potassium uptake protein [Bacillaceae]

Protein Classification

potassium channel family protein( domain architecture ID 11426271)

potassium channel family protein spans the cell membrane to form a conduction pathway or pore, through which selective ions such as potassium, sodium, and calcium translocate across cell membranes, similar to Trk system potassium uptake protein TrkA

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
1-202 5.34e-59

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


:

Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 187.58  E-value: 5.34e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671551522   1 MKRAFAVIGLGRFGGSICRELTELGMDVMVIDKSEEKVNEYANLVSHAVVGNAVDETVLKSLGIRNFDHVIVAIGEDiQA 80
Cdd:COG0569   94 LKMHVIIIGAGRVGRSLARELEEEGHDVVVIDKDPERVERLAEEDVLVIVGDATDEEVLEEAGIEDADAVIAATGDD-EA 172
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671551522  81 SILTTLMLKELGVKNITVKAQNDYHEKVLSKIGADAVVHPERDMGKRIAHNIVSNNVLDYLELSD-EHSIVEIKAS--HK 157
Cdd:COG0569  173 NILACLLAKELGVPRIIARANDPEYADLLERLGADVVISPERLAARRIARLLLRPGVLDVLELADgDAEIVEVTVPegSP 252
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 671551522 158 LDGRSIIDLDIRARYGITIVAIKRDKEIIVsPQASEPIRENDILI 202
Cdd:COG0569  253 LVGKTLKELDLRERYGVTVVAIKRGGEVII-PSGDTVLEAGDELI 296
 
Name Accession Description Interval E-value
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
1-202 5.34e-59

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 187.58  E-value: 5.34e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671551522   1 MKRAFAVIGLGRFGGSICRELTELGMDVMVIDKSEEKVNEYANLVSHAVVGNAVDETVLKSLGIRNFDHVIVAIGEDiQA 80
Cdd:COG0569   94 LKMHVIIIGAGRVGRSLARELEEEGHDVVVIDKDPERVERLAEEDVLVIVGDATDEEVLEEAGIEDADAVIAATGDD-EA 172
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671551522  81 SILTTLMLKELGVKNITVKAQNDYHEKVLSKIGADAVVHPERDMGKRIAHNIVSNNVLDYLELSD-EHSIVEIKAS--HK 157
Cdd:COG0569  173 NILACLLAKELGVPRIIARANDPEYADLLERLGADVVISPERLAARRIARLLLRPGVLDVLELADgDAEIVEVTVPegSP 252
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 671551522 158 LDGRSIIDLDIRARYGITIVAIKRDKEIIVsPQASEPIRENDILI 202
Cdd:COG0569  253 LVGKTLKELDLRERYGVTVVAIKRGGEVII-PSGDTVLEAGDELI 296
TrkA_N pfam02254
TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include ...
5-120 1.87e-30

TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.


Pssm-ID: 426679 [Multi-domain]  Cd Length: 115  Bit Score: 108.38  E-value: 1.87e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671551522    5 FAVIGLGRFGGSICRELTElGMDVMVIDKSEEKVNEYANLVSHAVVGNAVDETVLKSLGIRNFDHVIVAIGEDiQASILT 84
Cdd:pfam02254   1 IIIIGYGRVGRSLAEELSE-GGDVVVIDKDEERVEELREEGVPVVVGDATDEEVLEEAGIEEADAVIAATGDD-EANILI 78
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 671551522   85 TLMLKEL-GVKNITVKAQNDYHEKVLSKIGADAVVHP 120
Cdd:pfam02254  79 VLLARELnPDKKIIARANDPEHAELLRRLGADHVISP 115
trkA PRK09496
Trk system potassium transporter TrkA;
7-215 2.15e-17

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 79.78  E-value: 2.15e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671551522   7 VIGLGRFGGSICRELTELGMDVMVIDKSEEKVNEyanLVSH----AVVGNAVDETVLKSLGIRNFDHVIVAIGEDiQASI 82
Cdd:PRK09496   5 IVGAGQVGYTLAENLSGENNDVTVIDTDEERLRR---LQDRldvrTVVGNGSSPDVLREAGAEDADLLIAVTDSD-ETNM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671551522  83 LTTLMLKEL-GVKN-IT-VKAQnDY--HEKVLSK--IGADAVVHPERDMGKRIAHNIVSNNVLDYLELSDEH-SIVEIKA 154
Cdd:PRK09496  81 VACQIAKSLfGAPTtIArVRNP-EYaeYDKLFSKeaLGIDLLISPELLVAREIARLIEYPGALDVEEFADGRvQLVEVKV 159
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 671551522 155 SH--KLDGRSIIDLDIRAR-YGITIVAIKRDKEIIVsPQASEPIRENDILIVIGADSDINRFEK 215
Cdd:PRK09496 160 YEgsPLVGKPLSDLREHFPdIDVRVVAIFRGGRLII-PRGDTVIEAGDEVYFIGAREHIRAVMS 222
NAD_bind_Leu_Phe_Val_DH cd01075
NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine ...
3-52 5.04e-03

NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Amino acid dehydrogenase (DH) is a widely distributed family of enzymes that catalyzes the oxidative deamination of an amino acid to its keto acid and ammonia with concomitant reduction of NADP+. For example, leucine DH catalyzes the reversible oxidative deamination of L-leucine and several other straight or branched chain amino acids to the corresponding 2-oxoacid derivative. Amino acid DH -like NAD(P)-binding domains are members of the Rossmann fold superfamily and include glutamate, leucine, and phenylalanine DHs, methylene tetrahydrofolate DH, methylene-tetrahydromethanopterin DH, methylene-tetrahydropholate DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.


Pssm-ID: 133444  Cd Length: 200  Bit Score: 36.80  E-value: 5.04e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 671551522   3 RAFAVIGLGRFGGSICRELTELGMDVMVIDKSEEKVNEYANLVSHAVVGN 52
Cdd:cd01075   29 KTVAVQGLGKVGYKLAEHLLEEGAKLIVADINEEAVARAAELFGATVVAP 78
 
Name Accession Description Interval E-value
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
1-202 5.34e-59

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 187.58  E-value: 5.34e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671551522   1 MKRAFAVIGLGRFGGSICRELTELGMDVMVIDKSEEKVNEYANLVSHAVVGNAVDETVLKSLGIRNFDHVIVAIGEDiQA 80
Cdd:COG0569   94 LKMHVIIIGAGRVGRSLARELEEEGHDVVVIDKDPERVERLAEEDVLVIVGDATDEEVLEEAGIEDADAVIAATGDD-EA 172
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671551522  81 SILTTLMLKELGVKNITVKAQNDYHEKVLSKIGADAVVHPERDMGKRIAHNIVSNNVLDYLELSD-EHSIVEIKAS--HK 157
Cdd:COG0569  173 NILACLLAKELGVPRIIARANDPEYADLLERLGADVVISPERLAARRIARLLLRPGVLDVLELADgDAEIVEVTVPegSP 252
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 671551522 158 LDGRSIIDLDIRARYGITIVAIKRDKEIIVsPQASEPIRENDILI 202
Cdd:COG0569  253 LVGKTLKELDLRERYGVTVVAIKRGGEVII-PSGDTVLEAGDELI 296
TrkA_N pfam02254
TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include ...
5-120 1.87e-30

TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.


Pssm-ID: 426679 [Multi-domain]  Cd Length: 115  Bit Score: 108.38  E-value: 1.87e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671551522    5 FAVIGLGRFGGSICRELTElGMDVMVIDKSEEKVNEYANLVSHAVVGNAVDETVLKSLGIRNFDHVIVAIGEDiQASILT 84
Cdd:pfam02254   1 IIIIGYGRVGRSLAEELSE-GGDVVVIDKDEERVEELREEGVPVVVGDATDEEVLEEAGIEEADAVIAATGDD-EANILI 78
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 671551522   85 TLMLKEL-GVKNITVKAQNDYHEKVLSKIGADAVVHP 120
Cdd:pfam02254  79 VLLARELnPDKKIIARANDPEHAELLRRLGADHVISP 115
trkA PRK09496
Trk system potassium transporter TrkA;
7-215 2.15e-17

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 79.78  E-value: 2.15e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671551522   7 VIGLGRFGGSICRELTELGMDVMVIDKSEEKVNEyanLVSH----AVVGNAVDETVLKSLGIRNFDHVIVAIGEDiQASI 82
Cdd:PRK09496   5 IVGAGQVGYTLAENLSGENNDVTVIDTDEERLRR---LQDRldvrTVVGNGSSPDVLREAGAEDADLLIAVTDSD-ETNM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671551522  83 LTTLMLKEL-GVKN-IT-VKAQnDY--HEKVLSK--IGADAVVHPERDMGKRIAHNIVSNNVLDYLELSDEH-SIVEIKA 154
Cdd:PRK09496  81 VACQIAKSLfGAPTtIArVRNP-EYaeYDKLFSKeaLGIDLLISPELLVAREIARLIEYPGALDVEEFADGRvQLVEVKV 159
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 671551522 155 SH--KLDGRSIIDLDIRAR-YGITIVAIKRDKEIIVsPQASEPIRENDILIVIGADSDINRFEK 215
Cdd:PRK09496 160 YEgsPLVGKPLSDLREHFPdIDVRVVAIFRGGRLII-PRGDTVIEAGDEVYFIGAREHIRAVMS 222
trkA PRK09496
Trk system potassium transporter TrkA;
7-215 1.11e-16

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 77.86  E-value: 1.11e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671551522   7 VIGLGRFGGSICRELTELGMDVMVIDKSEEKVNEYANLVSHAVV--GNAVDETVLKSLGIRNFDhVIVAIGEDIQASILT 84
Cdd:PRK09496 236 IVGGGNIGYYLAKLLEKEGYSVKLIERDPERAEELAEELPNTLVlhGDGTDQELLEEEGIDEAD-AFIALTNDDEANILS 314
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671551522  85 TLMLKELGVKNITVKAQNDYHEKVLSKIGADAVVHPerdmgkriaHNIVSNNVLDYLELSDEHSI----------VEIKA 154
Cdd:PRK09496 315 SLLAKRLGAKKVIALVNRPAYVDLVEGLGIDIAISP---------RQATASEILRHVRRGDIVAVhslrrgaaeaIEAVA 385
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 671551522 155 SH--KLDGRSIIDLDIRAryGITIVAIKRDKEIIVsPQASEPIRENDILIVIGADSD-INRFEK 215
Cdd:PRK09496 386 HEtsKVVGKPLKDLKLPK--GVLIGAIVRGGEVII-PTGDTVIEPGDHVIVFVLDKKfVPDVEK 446
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
150-215 8.58e-16

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 71.11  E-value: 8.58e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 671551522 150 VEIKASHKLDGRSIIDLDIRARYGITIVAIKRDKEIIVSPQASEPIRENDILIVIGADSDINRFEK 215
Cdd:COG0490   73 VKVPPGSPLVGKTLGELNLRQRTGVTVVAIRRGGEVILSPGPDTVLEAGDTLVVVGTREQLERLEE 138
Kch COG1226
Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism];
7-159 2.35e-15

Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism];


Pssm-ID: 440839 [Multi-domain]  Cd Length: 279  Bit Score: 72.84  E-value: 2.35e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671551522   7 VIGLGRFGGSICRELTELGMDVMVIDKSEEKVNEYANLVSHAVVGNAVDETVLKSLGIRNFDHVIVAIGeDIQASILTTL 86
Cdd:COG1226  129 IAGFGRVGQIVARLLRAEGIPFVVIDLDPERVEELRRFGIKVYYGDATRPDVLEAAGIERARALVVAID-DPEAALRIVE 207
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 671551522  87 MLKEL--GVKnITVKAQNDYHEKVLSKIGADAVVHPERDMGKRIAhnivsNNVLDYLELSDEHSIVEIKASHKLD 159
Cdd:COG1226  208 LARELnpDLK-IIARARDREHAEELRQAGADEVVRETFESALQLA-----RHALEALGVPEEEAARAIQEFRRRD 276
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
149-215 1.05e-12

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 61.09  E-value: 1.05e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 671551522  149 IVEIKASHKLDGRSIIDLDIRARYGITIVAIKRDKEIIVsPQASEPIRENDILIVIGADSDINRFEK 215
Cdd:pfam02080   3 EVTVPENSPLVGKTLKELNLPERFGVRIVAIRRGGRLII-PSGDTVLEAGDRLLVIGTPDDLAALRE 68
COG3273 COG3273
Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];
150-215 2.84e-10

Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];


Pssm-ID: 442504 [Multi-domain]  Cd Length: 387  Bit Score: 58.91  E-value: 2.84e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 671551522 150 VEIKASHKLDGRSIIDLDIRARYGITIVAIKRDKEIIVSPQASEPIRENDILIVIGADSDINRFEK 215
Cdd:COG3273  318 VTVPPGSPLVGKTLGELKLETETGVRVIAIRRGGGWIYDPDGDTRLRAGDVLIVKGTREGLERLEE 383
PRK05326 PRK05326
potassium/proton antiporter;
138-215 6.45e-09

potassium/proton antiporter;


Pssm-ID: 235410 [Multi-domain]  Cd Length: 562  Bit Score: 55.21  E-value: 6.45e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 671551522 138 LDYLELSD-EHSIVEIKASHKLDGRSIIDLDIRAryGITIVAIKRDKEIIVsPQASEPIRENDILIVIGADSDINRFEK 215
Cdd:PRK05326 406 LDPLEESDaELLEYRVPAGSWLVGKALRDLRLPR--GALIALIIRDGKLLV-PTGSTRLKAGDVLLVLGPERDLPALER 481
YbjL COG2985
Uncharacterized membrane protein YbjL, putative transporter [General function prediction only]; ...
115-217 2.01e-06

Uncharacterized membrane protein YbjL, putative transporter [General function prediction only];


Pssm-ID: 442224 [Multi-domain]  Cd Length: 543  Bit Score: 47.81  E-value: 2.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671551522 115 DAVVHPERDMGKRIAHNIVSNNVLDYLELsdehsIVEikaSHKLDGRSIIDLDIRARYGITIVAIKR-DKEIIVSPqaSE 193
Cdd:COG2985  263 EALEAAEALLGEEVDDSELLDSDLDVRRI-----VVT---NKEVAGKTLGELNLRNRFGVVITRVRRgGVELPATP--DT 332
                         90       100
                 ....*....|....*....|....
gi 671551522 194 PIRENDILIVIGADSDINRFEKKV 217
Cdd:COG2985  333 VLQLGDRLTVVGPKEDVERVAKLL 356
YbjL COG2985
Uncharacterized membrane protein YbjL, putative transporter [General function prediction only]; ...
158-217 3.00e-06

Uncharacterized membrane protein YbjL, putative transporter [General function prediction only];


Pssm-ID: 442224 [Multi-domain]  Cd Length: 543  Bit Score: 47.04  E-value: 3.00e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 671551522 158 LDGRSIIDLDIRARYGITIVAIKRDKEIIVsPQASEPIRENDILIVIGADSDINRFEKKV 217
Cdd:COG2985  214 LVGKTVAELEALLGTRVVISRIRRGGEIIV-PTPDTVLQEGDIVLVVGTREALEAAEALL 272
PRK09599 PRK09599
NADP-dependent phosphogluconate dehydrogenase;
1-42 3.15e-03

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236582 [Multi-domain]  Cd Length: 301  Bit Score: 37.81  E-value: 3.15e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 671551522   1 MKraFAVIGLGRFGGSICRELTELGMDVMVIDKSEEKVNEYA 42
Cdd:PRK09599   1 MQ--LGMIGLGRMGGNMARRLLRGGHEVVGYDRNPEAVEALA 40
PRK10669 PRK10669
putative cation:proton antiport protein; Provisional
7-129 4.93e-03

putative cation:proton antiport protein; Provisional


Pssm-ID: 182633 [Multi-domain]  Cd Length: 558  Bit Score: 37.39  E-value: 4.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671551522   7 VIGLGRFGGSICRELTELGMDVMVIDKSEEKVNEYANLVSHAVVGNAVDETVLKSLGIRNFDHVIVAIGEDIQASILTTL 86
Cdd:PRK10669 422 LVGYGRVGSLLGEKLLAAGIPLVVIETSRTRVDELRERGIRAVLGNAANEEIMQLAHLDCARWLLLTIPNGYEAGEIVAS 501
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 671551522  87 MLKELGVKNITVKAQNDYHEKVLSKIGADAVVHPERDMGKRIA 129
Cdd:PRK10669 502 AREKRPDIEIIARAHYDDEVAYITERGANQVVMGEREIARTML 544
NAD_bind_Leu_Phe_Val_DH cd01075
NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine ...
3-52 5.04e-03

NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Amino acid dehydrogenase (DH) is a widely distributed family of enzymes that catalyzes the oxidative deamination of an amino acid to its keto acid and ammonia with concomitant reduction of NADP+. For example, leucine DH catalyzes the reversible oxidative deamination of L-leucine and several other straight or branched chain amino acids to the corresponding 2-oxoacid derivative. Amino acid DH -like NAD(P)-binding domains are members of the Rossmann fold superfamily and include glutamate, leucine, and phenylalanine DHs, methylene tetrahydrofolate DH, methylene-tetrahydromethanopterin DH, methylene-tetrahydropholate DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.


Pssm-ID: 133444  Cd Length: 200  Bit Score: 36.80  E-value: 5.04e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 671551522   3 RAFAVIGLGRFGGSICRELTELGMDVMVIDKSEEKVNEYANLVSHAVVGN 52
Cdd:cd01075   29 KTVAVQGLGKVGYKLAEHLLEEGAKLIVADINEEAVARAAELFGATVVAP 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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