|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
1-586 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 1023.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 1 MRKTKIVCTIGPASESVEKLTQLMEAGMNVARLNFSHGDFEEHGARIKNIREAAEITGNNIAILLDTKGPEIRTNNMKDG 80
Cdd:PRK06354 7 MRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFEDG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 81 AIELVAGNDIIVSMTEVEGTTEKFSVTYEGLIDDVDPGSKILLDDGLIGLEVTKIDKTAGEIHTKILNSGTLKNKKGVNV 160
Cdd:PRK06354 87 PIELKTGDEFILTSREVLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKADGELHCKVLVGGVLSNKKGVNF 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 161 PGVAVKLPGMTEKDANDIRFGIEQGIDFIAASFVRRASDVLEIKQLLEDNNASHIHIIPKIENQEGVDNIDEILEVSDGL 240
Cdd:PRK06354 167 PGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHNGKHIPIIAKIEKQEAIDNIDAILELCDGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 241 MVARGDLGVEIPAEEVPLVQKLLIKKCNTLGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSY 320
Cdd:PRK06354 247 MVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETAAGDY 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 321 PVEAVQTMNNIASRAEEALNYKEILSKRSKdSEHSITDSIGQSVAHTALNLEVKAVITPTGSGHTARMISKYRPEAPIVA 400
Cdd:PRK06354 327 PVEAVQTMATIAVRIEKDLPYRDILSKRPE-FTTTITNAISQAVSHIALQLDAAAIVTLTKSGATARNVSKYRPKTPILA 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 401 VTYDASIQRQLALVWGVYPRLSQKSESTDEMLDVAVQEGVNSSIVTHGDLVVITAGLPVGEAGTTNIMKIHVIGDVLAKG 480
Cdd:PRK06354 406 VTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVVITAGTLVGESGSTDLMKVHVVGAVVAKG 485
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 481 QGIGRKTAFGKAVIATTAKEaLDKVNFGSILVTNATDRDMVPALEKCSAVIVEEGGLTSHAAVVGLNIGIPVIVGVENAT 560
Cdd:PRK06354 486 QGIGRKSVSGKARVAKTAAE-VAKVNEGDILVTPSTDADMIPAIEKAAAIITEEGGLTSHAAVVGLRLGIPVIVGVKNAT 564
|
570 580
....*....|....*....|....*.
gi 671552258 561 SILKDGQDITVDSRSGYVYSGHASVL 586
Cdd:PRK06354 565 SLIKDGQIITVDAARGVVYSGHASVL 590
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
1-473 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 809.65 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 1 MRKTKIVCTIGPASESVEKLTQLMEAGMNVARLNFSHGDFEEHGARIKNIREAAEITGNNIAILLDTKGPEIRTNNMKDG 80
Cdd:COG0469 2 MRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 81 AIELVAGNDIIVSMTEVEGTTEKFSVTYEGLIDDVDPGSKILLDDGLIGLEVTKIDKTagEIHTKILNSGTLKNKKGVNV 160
Cdd:COG0469 82 PVELKKGDTFTLTTDDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGD--EVVCEVVNGGVLSSRKGVNL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 161 PGVAVKLPGMTEKDANDIRFGIEQGIDFIAASFVRRASDVLEIKQLLEDNNaSHIHIIPKIENQEGVDNIDEILEVSDGL 240
Cdd:COG0469 160 PGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAG-GRAPIIAKIEKPEAVENLDEIIEASDGI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 241 MVARGDLGVEIPAEEVPLVQKLLIKKCNTLGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSY 320
Cdd:COG0469 239 MVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKY 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 321 PVEAVQTMNNIASRAEEALNYKEILSKRSKDSEHSITDSIGQSVAHTALNLEVKAVITPTGSGHTARMISKYRPEAPIVA 400
Cdd:COG0469 319 PVEAVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILA 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 671552258 401 VTYDASIQRQLALVWGVYPRLSQKSESTDEMLDVAVQEGVNSSIVTHGDLVVITAGLPVGEAGTTNIMKIHVI 473
Cdd:COG0469 399 LTPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
1-473 |
0e+00 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 687.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 1 MRKTKIVCTIGPASESVEKLTQLMEAGMNVARLNFSHGDFEEHGARIKNIREAAEITGNNIAILLDTKGPEIRTNNMKDG 80
Cdd:cd00288 1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 81 -AIELVAGNDIIVSM--TEVEGTTEKFSVTYEGLIDDVDPGSKILLDDGLIGLEVTKIDKtAGEIHTKILNSGTLKNKKG 157
Cdd:cd00288 81 kDISLKAGDKFLVTTdpAAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDD-DKTLVCEVLNGGVLGSRKG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 158 VNVPGVAVKLPGMTEKDANDIRFGIEQGIDFIAASFVRRASDVLEIKQLLEDNnASHIHIIPKIENQEGVDNIDEILEVS 237
Cdd:cd00288 160 VNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEK-GKDIKIIAKIENQEGVNNFDEILEAS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 238 DGLMVARGDLGVEIPAEEVPLVQKLLIKKCNTLGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAA 317
Cdd:cd00288 239 DGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 318 GSYPVEAVQTMNNIASRAEEALNYKEILSKRSKDSEH--SITDSIGQSVAHTALNLEVKAVITPTGSGHTARMISKYRPE 395
Cdd:cd00288 319 GKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRptSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPN 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 396 APIVAVTYDASIQRQLALVWGVYPRLSQK-----SESTDEMLDVAVQEGVNSSIVTHGDLVVITAGLPVGeAGTTNIMKI 470
Cdd:cd00288 399 APIIAVTRNEQTARQLHLYRGVYPVLFEEpkpgwQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVG-SGSTNTMRI 477
|
...
gi 671552258 471 HVI 473
Cdd:cd00288 478 LTV 480
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
2-470 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 659.36 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 2 RKTKIVCTIGPASESVEKLTQLMEAGMNVARLNFSHGDFEEHGARIKNIREAAEITGNNIAILLDTKGPEIRTNNMKDGA 81
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 82 IELVAGNDIIVSMT--EVEGTTEKFSVTYEGLIDDVDPGSKILLDDGLIGLEVTKIDKTagEIHTKILNSGTLKNKKGVN 159
Cdd:TIGR01064 81 VKLKKGDKVIITTDdiKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGD--KVICEVLNGGTLKSKKGVN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 160 VPGVAVKLPGMTEKDANDIRFGIEQGIDFIAASFVRRASDVLEIKQLLEDNNASHIHIIPKIENQEGVDNIDEILEVSDG 239
Cdd:TIGR01064 159 LPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKDVKIIAKIENQEGVDNIDEIAEASDG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 240 LMVARGDLGVEIPAEEVPLVQKLLIKKCNTLGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGS 319
Cdd:TIGR01064 239 IMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 320 YPVEAVQTMNNIASRAEEALNYKEILSKRSKDSEH--SITDSIGQSVAHTALNLEVKAVITPTGSGHTARMISKYRPEAP 397
Cdd:TIGR01064 319 YPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKpsTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAP 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 671552258 398 IVAVTYDASIQRQLALVWGVYPRL-SQKSESTDEMLDVAVQEGVNSSIVTHGDLVVITAGLPVGEAGTTNIMKI 470
Cdd:TIGR01064 399 IIAVTPNERVARQLALYWGVFPFLvDEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
1-345 |
0e+00 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 530.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 1 MRKTKIVCTIGPASESVEKLTQLMEAGMNVARLNFSHGDFEEHGARIKNIREAAEITGNNIAILLDTKGPEIRTNNMKDG 80
Cdd:pfam00224 1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 81 A--IELVAGNDIIVSMTEV---EGTTEKFSVTYEGLIDDVDPGSKILLDDGLIGLEVTKIDKtAGEIHTKILNSGTLKNK 155
Cdd:pfam00224 81 KkdIELKAGDEMIVSTDAKykgACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDD-DKTLVVEVLNGGVIGSR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 156 KGVNVPGVAVKLPGMTEKDANDIRFGIEQGIDFIAASFVRRASDVLEIKQLLEDNNaSHIHIIPKIENQEGVDNIDEILE 235
Cdd:pfam00224 160 KGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAG-KNIQIIAKIENQEGVNNFDEILE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 236 VSDGLMVARGDLGVEIPAEEVPLVQKLLIKKCNTLGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGET 315
Cdd:pfam00224 239 ATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGET 318
|
330 340 350
....*....|....*....|....*....|
gi 671552258 316 AAGSYPVEAVQTMNNIASRAEEALNYKEIL 345
Cdd:pfam00224 319 AKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
1-586 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 1023.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 1 MRKTKIVCTIGPASESVEKLTQLMEAGMNVARLNFSHGDFEEHGARIKNIREAAEITGNNIAILLDTKGPEIRTNNMKDG 80
Cdd:PRK06354 7 MRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFEDG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 81 AIELVAGNDIIVSMTEVEGTTEKFSVTYEGLIDDVDPGSKILLDDGLIGLEVTKIDKTAGEIHTKILNSGTLKNKKGVNV 160
Cdd:PRK06354 87 PIELKTGDEFILTSREVLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKADGELHCKVLVGGVLSNKKGVNF 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 161 PGVAVKLPGMTEKDANDIRFGIEQGIDFIAASFVRRASDVLEIKQLLEDNNASHIHIIPKIENQEGVDNIDEILEVSDGL 240
Cdd:PRK06354 167 PGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHNGKHIPIIAKIEKQEAIDNIDAILELCDGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 241 MVARGDLGVEIPAEEVPLVQKLLIKKCNTLGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSY 320
Cdd:PRK06354 247 MVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETAAGDY 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 321 PVEAVQTMNNIASRAEEALNYKEILSKRSKdSEHSITDSIGQSVAHTALNLEVKAVITPTGSGHTARMISKYRPEAPIVA 400
Cdd:PRK06354 327 PVEAVQTMATIAVRIEKDLPYRDILSKRPE-FTTTITNAISQAVSHIALQLDAAAIVTLTKSGATARNVSKYRPKTPILA 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 401 VTYDASIQRQLALVWGVYPRLSQKSESTDEMLDVAVQEGVNSSIVTHGDLVVITAGLPVGEAGTTNIMKIHVIGDVLAKG 480
Cdd:PRK06354 406 VTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVVITAGTLVGESGSTDLMKVHVVGAVVAKG 485
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 481 QGIGRKTAFGKAVIATTAKEaLDKVNFGSILVTNATDRDMVPALEKCSAVIVEEGGLTSHAAVVGLNIGIPVIVGVENAT 560
Cdd:PRK06354 486 QGIGRKSVSGKARVAKTAAE-VAKVNEGDILVTPSTDADMIPAIEKAAAIITEEGGLTSHAAVVGLRLGIPVIVGVKNAT 564
|
570 580
....*....|....*....|....*.
gi 671552258 561 SILKDGQDITVDSRSGYVYSGHASVL 586
Cdd:PRK06354 565 SLIKDGQIITVDAARGVVYSGHASVL 590
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
1-473 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 809.65 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 1 MRKTKIVCTIGPASESVEKLTQLMEAGMNVARLNFSHGDFEEHGARIKNIREAAEITGNNIAILLDTKGPEIRTNNMKDG 80
Cdd:COG0469 2 MRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 81 AIELVAGNDIIVSMTEVEGTTEKFSVTYEGLIDDVDPGSKILLDDGLIGLEVTKIDKTagEIHTKILNSGTLKNKKGVNV 160
Cdd:COG0469 82 PVELKKGDTFTLTTDDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGD--EVVCEVVNGGVLSSRKGVNL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 161 PGVAVKLPGMTEKDANDIRFGIEQGIDFIAASFVRRASDVLEIKQLLEDNNaSHIHIIPKIENQEGVDNIDEILEVSDGL 240
Cdd:COG0469 160 PGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAG-GRAPIIAKIEKPEAVENLDEIIEASDGI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 241 MVARGDLGVEIPAEEVPLVQKLLIKKCNTLGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSY 320
Cdd:COG0469 239 MVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKY 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 321 PVEAVQTMNNIASRAEEALNYKEILSKRSKDSEHSITDSIGQSVAHTALNLEVKAVITPTGSGHTARMISKYRPEAPIVA 400
Cdd:COG0469 319 PVEAVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILA 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 671552258 401 VTYDASIQRQLALVWGVYPRLSQKSESTDEMLDVAVQEGVNSSIVTHGDLVVITAGLPVGEAGTTNIMKIHVI 473
Cdd:COG0469 399 LTPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
1-473 |
0e+00 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 687.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 1 MRKTKIVCTIGPASESVEKLTQLMEAGMNVARLNFSHGDFEEHGARIKNIREAAEITGNNIAILLDTKGPEIRTNNMKDG 80
Cdd:cd00288 1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 81 -AIELVAGNDIIVSM--TEVEGTTEKFSVTYEGLIDDVDPGSKILLDDGLIGLEVTKIDKtAGEIHTKILNSGTLKNKKG 157
Cdd:cd00288 81 kDISLKAGDKFLVTTdpAAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDD-DKTLVCEVLNGGVLGSRKG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 158 VNVPGVAVKLPGMTEKDANDIRFGIEQGIDFIAASFVRRASDVLEIKQLLEDNnASHIHIIPKIENQEGVDNIDEILEVS 237
Cdd:cd00288 160 VNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEK-GKDIKIIAKIENQEGVNNFDEILEAS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 238 DGLMVARGDLGVEIPAEEVPLVQKLLIKKCNTLGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAA 317
Cdd:cd00288 239 DGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 318 GSYPVEAVQTMNNIASRAEEALNYKEILSKRSKDSEH--SITDSIGQSVAHTALNLEVKAVITPTGSGHTARMISKYRPE 395
Cdd:cd00288 319 GKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRptSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPN 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 396 APIVAVTYDASIQRQLALVWGVYPRLSQK-----SESTDEMLDVAVQEGVNSSIVTHGDLVVITAGLPVGeAGTTNIMKI 470
Cdd:cd00288 399 APIIAVTRNEQTARQLHLYRGVYPVLFEEpkpgwQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVG-SGSTNTMRI 477
|
...
gi 671552258 471 HVI 473
Cdd:cd00288 478 LTV 480
|
|
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
1-463 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 664.54 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 1 MRKTKIVCTIGPASESVEKLTQLMEAGMNVARLNFSHGDFEEHGARIKNIREAAEITGNNIAILLDTKGPEIRTNNMKDG 80
Cdd:PRK05826 3 LRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKEG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 81 AIELVAGNDIIVS-MTEVEGTTEKFSVTYEGLIDDVDPGSKILLDDGLIGLEVTKIDktAGEIHTKILNSGTLKNKKGVN 159
Cdd:PRK05826 83 KITLKTGDKFTLDtDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVD--GDEVETEVKNGGPLSNNKGIN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 160 VPGVAVKLPGMTEKDANDIRFGIEQGIDFIAASFVRRASDVLEIKQLLEDNNASHIHIIPKIENQEGVDNIDEILEVSDG 239
Cdd:PRK05826 161 IPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPHAKIIAKIERAEAVDNIDEIIEASDG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 240 LMVARGDLGVEIPAEEVPLVQKLLIKKCNTLGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGS 319
Cdd:PRK05826 241 IMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 320 YPVEAVQTMNNIASRAEEALNYKEIlSKRSKDSEHSITDSIGQSVAHTALNL-EVKAVITPTGSGHTARMISKYRPEAPI 398
Cdd:PRK05826 321 YPVEAVEAMARICKGAEKEFSINLS-KHRLDRQFDRIDEAIAMSAMYAANHLkGVKAIVALTESGRTARLISRFRPGAPI 399
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 671552258 399 VAVTYDASIQRQLALVWGVYPRLSQKSESTDEMLDVAVQEGVNSSIVTHGDLVVITAGLPVGEAG 463
Cdd:PRK05826 400 FAVTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVVVTSGDPMGTAG 464
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
2-470 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 659.36 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 2 RKTKIVCTIGPASESVEKLTQLMEAGMNVARLNFSHGDFEEHGARIKNIREAAEITGNNIAILLDTKGPEIRTNNMKDGA 81
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 82 IELVAGNDIIVSMT--EVEGTTEKFSVTYEGLIDDVDPGSKILLDDGLIGLEVTKIDKTagEIHTKILNSGTLKNKKGVN 159
Cdd:TIGR01064 81 VKLKKGDKVIITTDdiKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGD--KVICEVLNGGTLKSKKGVN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 160 VPGVAVKLPGMTEKDANDIRFGIEQGIDFIAASFVRRASDVLEIKQLLEDNNASHIHIIPKIENQEGVDNIDEILEVSDG 239
Cdd:TIGR01064 159 LPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKDVKIIAKIENQEGVDNIDEIAEASDG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 240 LMVARGDLGVEIPAEEVPLVQKLLIKKCNTLGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGS 319
Cdd:TIGR01064 239 IMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 320 YPVEAVQTMNNIASRAEEALNYKEILSKRSKDSEH--SITDSIGQSVAHTALNLEVKAVITPTGSGHTARMISKYRPEAP 397
Cdd:TIGR01064 319 YPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKpsTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAP 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 671552258 398 IVAVTYDASIQRQLALVWGVYPRL-SQKSESTDEMLDVAVQEGVNSSIVTHGDLVVITAGLPVGEAGTTNIMKI 470
Cdd:TIGR01064 399 IIAVTPNERVARQLALYWGVFPFLvDEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| PRK09206 |
PRK09206 |
pyruvate kinase PykF; |
1-473 |
0e+00 |
|
pyruvate kinase PykF;
Pssm-ID: 181699 [Multi-domain] Cd Length: 470 Bit Score: 621.30 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 1 MRKTKIVCTIGPASESVEKLTQLMEAGMNVARLNFSHGDFEEHGARIKNIREAAEITGNNIAILLDTKGPEIRTNNMKDG 80
Cdd:PRK09206 1 MKKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTMKLEGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 81 A-IELVAGNDIIVSM-TEVEGTTEKFSVTYEGLIDDVDPGSKILLDDGLIGLEVTKIdkTAGEIHTKILNSGTLKNKKGV 158
Cdd:PRK09206 81 NdVSLKAGQTFTFTTdKSVVGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAI--TGNEVICKVLNNGDLGENKGV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 159 NVPGVAVKLPGMTEKDANDIRFGIEQGIDFIAASFVRRASDVLEIKQLLEDNNASHIHIIPKIENQEGVDNIDEILEVSD 238
Cdd:PRK09206 159 NLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGENIQIISKIENQEGLNNFDEILEASD 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 239 GLMVARGDLGVEIPAEEVPLVQKLLIKKCNTLGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAG 318
Cdd:PRK09206 239 GIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 319 SYPVEAVQTMNNIASRAEEALNYKeiLSKRSKDSEHSITDSIGQSVAHTALNLEVKAVITPTGSGHTARMISKYRPEAPI 398
Cdd:PRK09206 319 KYPLEAVSIMATICERTDRVMNSR--LESNNDNRKLRITEAVCRGAVETAEKLDAPLIVVATQGGKSARSVRKYFPDATI 396
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 671552258 399 VAVTYDASIQRQLALVWGVYPRLSQKSESTDEMLDVAVQEGVNSSIVTHGDLVVITAGLPVgEAGTTNIMKIHVI 473
Cdd:PRK09206 397 LALTTNEKTARQLVLSKGVVPQLVKEIASTDDFYRLGKELALQSGLAQKGDVVVMVSGALV-PSGTTNTASVHVL 470
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
1-345 |
0e+00 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 530.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 1 MRKTKIVCTIGPASESVEKLTQLMEAGMNVARLNFSHGDFEEHGARIKNIREAAEITGNNIAILLDTKGPEIRTNNMKDG 80
Cdd:pfam00224 1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 81 A--IELVAGNDIIVSMTEV---EGTTEKFSVTYEGLIDDVDPGSKILLDDGLIGLEVTKIDKtAGEIHTKILNSGTLKNK 155
Cdd:pfam00224 81 KkdIELKAGDEMIVSTDAKykgACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDD-DKTLVVEVLNGGVIGSR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 156 KGVNVPGVAVKLPGMTEKDANDIRFGIEQGIDFIAASFVRRASDVLEIKQLLEDNNaSHIHIIPKIENQEGVDNIDEILE 235
Cdd:pfam00224 160 KGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAG-KNIQIIAKIENQEGVNNFDEILE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 236 VSDGLMVARGDLGVEIPAEEVPLVQKLLIKKCNTLGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGET 315
Cdd:pfam00224 239 ATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGET 318
|
330 340 350
....*....|....*....|....*....|
gi 671552258 316 AAGSYPVEAVQTMNNIASRAEEALNYKEIL 345
Cdd:pfam00224 319 AKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
|
|
| PRK06247 |
PRK06247 |
pyruvate kinase; Provisional |
2-474 |
3.99e-180 |
|
pyruvate kinase; Provisional
Pssm-ID: 180487 [Multi-domain] Cd Length: 476 Bit Score: 517.17 E-value: 3.99e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 2 RKTKIVCTIGPASESVEKLTQLMEAGMNVARLNFSHGDFEEHGARIKNIREAAEITGNNIAILLDTKGPEIRTNNMKDGA 81
Cdd:PRK06247 5 RRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRFADGK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 82 IELVAGNDIIVSMTEVEGTTEKFSVTYEGLIDDVDPGSKILLDDGLIGLEVTKIDktAGEIHTKILNSGTLKNKKGVNVP 161
Cdd:PRK06247 85 VQLANGQTFRLDVDDAPGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACD--GDDVVCRVVEGGPVSDRKGVSLP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 162 GVAVKLPGMTEKDANDIRFGIEQGIDFIAASFVRRASDVLEIKQLLEDNNAshihIIPKIENQEGVDNIDEILEVSDGLM 241
Cdd:PRK06247 163 GTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIGGRVP----VMAKIEKPQAIDRLEAIVEASDAIM 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 242 VARGDLGVEIPAEEVPLVQKLLIKKCNTLGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYP 321
Cdd:PRK06247 239 VARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKYP 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 322 VEAVQTMNNIASRAEEALNYKEILSKRSKDSEHSITDSIGQSVAHTALNLEVKAVITPTGSGHTARMISKYRPEAPIVAV 401
Cdd:PRK06247 319 VEAVRTMARIIRQVERDPTYPPLIHAQRPQPEATKRDAISYAARDIAERLDLAALVAYTSSGDTALRAARERPPLPILAL 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 671552258 402 TYDASIQRQLALVWGVYPRLSQKSESTDEMLDVAVQEGVNSSIVTHGDLVVITAGLPVGEAGTTNIMKIHVIG 474
Cdd:PRK06247 399 TPNPETARRLALTWGVHCVVVDDARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGTPGSTNMLRIAYIG 471
|
|
| PLN02461 |
PLN02461 |
Probable pyruvate kinase |
3-470 |
4.77e-175 |
|
Probable pyruvate kinase
Pssm-ID: 215255 [Multi-domain] Cd Length: 511 Bit Score: 505.67 E-value: 4.77e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 3 KTKIVCTIGPASESVEKLTQLMEAGMNVARLNFSHGDFEEHGARIKNIREAAEITGNNIAILLDTKGPEIRTNNMKDG-A 81
Cdd:PLN02461 22 KTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILCAVMLDTKGPEIRTGFLKDGkP 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 82 IELVAGNDIIVSMT-EVEGTTEKFSVTYEGLIDDVDPGSKILLDDGLIGLEVTKIDKTAGEIHTKILNSGTLKNKKGVNV 160
Cdd:PLN02461 102 VQLKQGQEITITTDySIKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLSCDVEAGTVRCRCENSAMLGERKNVNL 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 161 PGVAVKLPGMTEKDANDI-RFGIEQGIDFIAASFVRRASDVLEIKQLLeDNNASHIHIIPKIENQEGVDNIDEILEVSDG 239
Cdd:PLN02461 182 PGVVVDLPTLTEKDKEDIlQWGVPNKIDFIALSFVRKGSDLVEVRKVL-GEHAKSILLISKVENQEGLDNFDDILAESDA 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 240 LMVARGDLGVEIPAEEVPLVQKLLIKKCNTLGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGS 319
Cdd:PLN02461 261 FMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGETAAGA 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 320 YPVEAVQTMNNIASRAEEALNY----KEILskRSKDSEHSITDSIGQSVAHTALNLEVKAVITPTGSGHTARMISKYRPE 395
Cdd:PLN02461 341 YPELAVKTMARICREAEASLDYgalfKEIM--RSAPLPMSPLESLASSAVRTANKVKASLIVVLTRGGTTARLVAKYRPA 418
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 396 APIVAVTY-------------DASIQRQLALVWGVYPRLSQKS------ESTDEMLDVAVQEGVNSSIVTHGDLVVitag 456
Cdd:PLN02461 419 VPILSVVVpeittdsfdwscsDEAPARHSLIYRGLIPVLAEGSakatdsESTEEILEAAIEHAKKKGLCKPGDSVV---- 494
|
490
....*....|....
gi 671552258 457 lPVGEAGTTNIMKI 470
Cdd:PLN02461 495 -ALHRIGGASVIKI 507
|
|
| PykA2 |
COG3848 |
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms]; |
266-586 |
1.02e-161 |
|
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
Pssm-ID: 443058 Cd Length: 321 Bit Score: 463.99 E-value: 1.02e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 266 KCNTLGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQTMNNIASRAEEALNYKEIL 345
Cdd:COG3848 1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYREQR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 346 SKRSKDSEHSITDSIGQSVAHTALNLEVKAVITPTGSGHTARMISKYRPEAPIVAVTYDASIQRQLALVWGVYPRLSQKS 425
Cdd:COG3848 81 VPRAKESSTTITDAISHAVATTAADLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVEES 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 426 ESTDEMLDVAVQEGVNSSIVTHGDLVVITAGLPVGEAGTTNIMKIHVIGDVLAKGQGIGRKTAFGKAVIATTAKEALDKV 505
Cdd:COG3848 161 ASTDEMFAVAVALALEAGLVKDGDLVVITAGVPVGVSGTTNLLKVHVVGDVLAKGQGIGRGSVTGKAVVARSAEEALEKF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 506 NFGSILVTNATDRDMVPALEKCSAVIVEEGGLTSHAAVVGLNIGIPVIVGVENATSILKDGQDITVDSRSGYVYSGHASV 585
Cdd:COG3848 241 EEGDILVVPSTDAEFVPAIEKAAGIITEEGGLTSHAAIVGLELGIPVIVGAEGATEILKDGQVVTVDAERGVVYRGAVNV 320
|
.
gi 671552258 586 L 586
Cdd:COG3848 321 L 321
|
|
| PTZ00066 |
PTZ00066 |
pyruvate kinase; Provisional |
2-470 |
1.67e-152 |
|
pyruvate kinase; Provisional
Pssm-ID: 173361 [Multi-domain] Cd Length: 513 Bit Score: 448.06 E-value: 1.67e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 2 RKTKIVCTIGPASESVEKLTQLMEAGMNVARLNFSHGDFEEHGARIKNIREAAEITGN-NIAILLDTKGPEIRTNNMKDG 80
Cdd:PTZ00066 38 KKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREAAKARPNaNLGILLDTKGPEIRTGFLKNH 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 81 -AIELVAGNDI-IVSMTEVEGTTEKFSVTYEGLIDDVDPGSKILLDDGLIGLEVTKIDKTagEIHTKILNSGTLKNKKGV 158
Cdd:PTZ00066 118 kPITLKEGQTLkITTDYTFLGDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEVHDD--YIITKVLNNATIGERKNM 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 159 NVPGVAVKLPGMTEKDANDI-RFGIEQGIDFIAASFVRRASDVLEIKQLLEDNnASHIHIIPKIENQEGVDNIDEILEVS 237
Cdd:PTZ00066 196 NLPGVKVELPVIGEKDKNDIlNFAIPMGCDFIALSFVQSADDVRLCRQLLGER-GRHIKIIPKIENIEGLINFDEILAES 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 238 DGLMVARGDLGVEIPAEEVPLVQKLLIKKCNTLGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAA 317
Cdd:PTZ00066 275 DGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGETAN 354
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 318 GSYPVEAVQTMNNIASRAEEALNYKEILSK--RSKDSEHSITDSIGQSVAHTALNLEVKAVITPTGSGHTARMISKYRPE 395
Cdd:PTZ00066 355 GKFPVEAVNIMAKICFEAETCIDYRVLYHAihLAVPTPVSVQEAVARSAVETAEDINAKLIIALTETGNTARLISKYRPS 434
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 671552258 396 APIVAVTYDASIQRQLALVWGVYPRLSQKSESTDEMLDVAVQEGVNSSIVTHGDLVVITAGLPVGEAGTTNIMKI 470
Cdd:PTZ00066 435 CTILALSASPSVVKSLSVARGVTTYVVNSFQGTDVVIRNAIALAKERGLVESGDSAIAVHGVKEEVAGSSNLMKV 509
|
|
| PTZ00300 |
PTZ00300 |
pyruvate kinase; Provisional |
28-453 |
1.90e-126 |
|
pyruvate kinase; Provisional
Pssm-ID: 140321 [Multi-domain] Cd Length: 454 Bit Score: 379.39 E-value: 1.90e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 28 MNVARLNFSHGDFEEHGARIKNIREAAEITGNNIAILLDTKGPEIRTNNMKDGAIELVAGNDIIVSMT---EVEGTTEKF 104
Cdd:PTZ00300 1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGGEAVMERGATCYVTTDpafADKGTKDKF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 105 SVTYEGLIDDVDPGSKILLDDGLIGLEV-TKIDKTAgeIHTKILNSGTLKNKKGVNVPGVAVKLPGMTEKDANDIRFGIE 183
Cdd:PTZ00300 81 YIDYQNLSKVVRPGGYIYIDDGILILHVqSHEDEQT--LKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 184 QGIDFIAASFVRRASDVLEIKQLLeDNNASHIHIIPKIENQEGVDNIDEILEVSDGLMVARGDLGVEIPAEEVPLVQKLL 263
Cdd:PTZ00300 159 QGVDMIFASFIRSAEQVGEVRKAL-GAKGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKIL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 264 IKKCNTLGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQTMNNIASRAEEALNYKE 343
Cdd:PTZ00300 238 ISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAVNEYV 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 344 ILS--KRSKDSEHSITDSIGQSVAHTALNLEVKAVITPTGSGHTARMISKYRPEAPIVAVTYDASIQRQLALVWGV---- 417
Cdd:PTZ00300 318 FFNsiKKLQPIPMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVesvf 397
|
410 420 430
....*....|....*....|....*....|....*...
gi 671552258 418 --YPRLSQkSESTDEMLDVAVQEGVNSSIVTHGDLVVI 453
Cdd:PTZ00300 398 fdAERLGH-DEGKEQRVAMGVGFAKSKGYVQSGDLMVV 434
|
|
| PLN02623 |
PLN02623 |
pyruvate kinase |
2-453 |
5.20e-119 |
|
pyruvate kinase
Pssm-ID: 215334 [Multi-domain] Cd Length: 581 Bit Score: 364.63 E-value: 5.20e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 2 RKTKIVCTIGPASESVEKLTQLMEAGMNVARLNFSHGDFEEHGARIKNIRE-AAEITGNNIAILLDTKGPEIRTNNMKDg 80
Cdd:PLN02623 110 RKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEyNAQSKDNVIAIMLDTKGPEVRSGDLPQ- 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 81 AIELVAGNDIIVSMTEVEGTTEKFSVTYEGLIDDVDPGSKILLDDGLIGLEVTKidKTAGEIHTKILNSGTLKNKKGVNV 160
Cdd:PLN02623 189 PIMLEEGQEFTFTIKRGVSTEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKS--KTSDSVKCEVVDGGELKSRRHLNV 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 161 PGVAVKLPGMTEKDANDIRFGIEQGIDFIAASFVRRASDVLEIKQLLEDNNAShIHIIPKIENQEGVDNIDEILEVSDGL 240
Cdd:PLN02623 267 RGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNAD-IHVIVKIESADSIPNLHSIITASDGA 345
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 241 MVARGDLGVEIPAEEVPLVQKLLIKKCNTLGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSY 320
Cdd:PLN02623 346 MVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKF 425
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 321 PVEAVQTMNNIASRAEEALNYKEILSKRSKDSEHSITDSIGQSVAHTALNLEVkAVITPTGSGHTARMISKYRPEAPIVA 400
Cdd:PLN02623 426 PLKAVKVMHTVALRTEATLPEGTTPPNLGQAFKNHMSEMFAFHATMMANTLGT-SIIVFTRTGFMAILLSHYRPSGTIFA 504
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 671552258 401 VTYDASIQRQLALVWGVYPRLSQKSESTDEMLDVAVQEGVNSSIVTHGDLVVI 453
Cdd:PLN02623 505 FTNEKRIQQRLALYQGVCPIYMQFSDDAEETFARALSLLLNKGMVKEGEEVAL 557
|
|
| PLN02765 |
PLN02765 |
pyruvate kinase |
4-470 |
1.26e-112 |
|
pyruvate kinase
Pssm-ID: 215409 [Multi-domain] Cd Length: 526 Bit Score: 346.27 E-value: 1.26e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 4 TKIVCTIGPASESVEKLTQLMEAGMNVARLNFSHGDFEEHGARIKNIREAAEITGNNIAILLDTKGPEIRTNNMKDGAIE 83
Cdd:PLN02765 30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNTKKLCAVMLDTVGPELQVINKTEKPIS 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 84 LVAGNdiIVSMT---EVEGTTEKFSVTYEGLIDDVDPGSKILLDDGLI-GLEVT----KIDKTAGE-IHTKILNSGTLKN 154
Cdd:PLN02765 110 LKAGN--TVTLTpdqSKEASSEVLPINFPGLAKAVKPGDTIFVGQYLFtGSETTsvwlEVDEVKGDdVVCTVKNSATLAG 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 155 KK-GVNVPGVAVKLPGMTEKDANDIR-FGIEQGIDFIAASFVRRASDVLEIKQLLEDNNASHIHIIPKIENQEGVDNIDE 232
Cdd:PLN02765 188 SLfTLHVSQVRIDLPTLSEKDKEVIStWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGLSQTQIFAKIENVEGLTHFDE 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 233 ILEVSDGLMVARGDLGVEIPAEEVPLVQKLLIKKCNTLGKPVITaTQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLS 312
Cdd:PLN02765 268 ILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVLDGADAILLG 346
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 313 GETAAGSYPVEAVQTMNNIASRAEEALN----YKEILSKRSKDSEHSitDSIGQSVAHTALNLEVKAVITPTGSGHTARM 388
Cdd:PLN02765 347 AETLRGLYPVETISTVGRICAEAEKVFNqdlyFKKTVKYVGEPMSHL--ESIASSAVRAAIKVKASVIIVFTSSGRAARL 424
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 389 ISKYRPEAPIVAV------------TYDASIQ-RQLALVWGVYPRLSQKSESTDE-------MLDVAVQEGVNSSIVTHG 448
Cdd:PLN02765 425 IAKYRPTMPVLSVviprlktnqlkwSFTGAFQaRQCLIVRGLFPMLADPRHSAEStsatnesVLKVALDHGKAAGVIKSH 504
|
490 500
....*....|....*....|..
gi 671552258 449 DLVVITAglPVGEAGTTNIMKI 470
Cdd:PLN02765 505 DRVVVCQ--KVGDSSVVKIIEL 524
|
|
| PLN02762 |
PLN02762 |
pyruvate kinase complex alpha subunit |
1-453 |
1.18e-106 |
|
pyruvate kinase complex alpha subunit
Pssm-ID: 215407 [Multi-domain] Cd Length: 509 Bit Score: 330.17 E-value: 1.18e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 1 MRKTKIVCTIGPASESVEKLTQLMEAGMNVARLNFSHGDFEEHGARIKNIREAAEITGNNIAILLDTKGPEIrtnNMKD- 79
Cdd:PLN02762 24 TRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEKGFAVAVMMDTEGSEI---HMGDl 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 80 -GAIELVA--GNDIIVSMTEVEGTTEKF--SVTYEGLIDDVDPGSKILLDDGLIGLEVtkIDKTAGEIHTKILNSGTLKN 154
Cdd:PLN02762 101 gGASSAKAedGEEWTFTVRKFDGSRPEFtiQVNYDGFAEDVKVGDELVVDGGMVRFEV--IEKIGPDVKCKCTDPGLLLP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 155 KKGVN-------VPGVAVKLPGMTEKDANDIRFGIEQGIDFIAASFVRRASDVLEIKQLLEDNNA-SHIHIIPKIENQEG 226
Cdd:PLN02762 179 RANLTfwrdgslVRERNAMLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARSRdSDIGVIAKIESLDS 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 227 VDNIDEILEVSDGLMVARGDLGVEIPAEEVPLVQKLLIKKCNTLGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGT 306
Cdd:PLN02762 259 LKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRA 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 307 DAIMLSGETAAGSYPVEAVQTMNNIASRAE---------EALNYKEIlskrSKDSEHSITDSIGQSVAHTALNLEVKAVI 377
Cdd:PLN02762 339 DALMLSGESAMGLYPEKALSVLRSVSLRMElwsreekrhEALELPQL----SSSLSDRISEEICNSAAKMANNLGVDAIF 414
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 671552258 378 TPTGSGHTARMISKYRPEAPIVAVTYDASIQRQLALVWGVYPRLSQKSESTDEMLDVAVQEGVNSSIVTHGDLVVI 453
Cdd:PLN02762 415 VYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLDFSDDMESNLNKTFSLLKARGMIKSGDLVIA 490
|
|
| PRK06739 |
PRK06739 |
pyruvate kinase; Validated |
7-336 |
6.22e-102 |
|
pyruvate kinase; Validated
Pssm-ID: 180676 [Multi-domain] Cd Length: 352 Bit Score: 312.65 E-value: 6.22e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 7 VCTIGPASESVEKLTQLMEAGMNVARLNFSHGDFEEHgariKNIREAAEITGNNIAILLDTKGPEIRTNNMKDGAIELVA 86
Cdd:PRK06739 6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESH----KDIIRLVKSLDDSIKILGDVQGPKIRLGEIKGEQITLQA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 87 GNDIIVSMTEVEGTTEKFSVTYEGLIDDVDPGSKILLDDGLIGLEVTKIdkTAGEIHTKILNSGTLKNKKGVNVPGVAVK 166
Cdd:PRK06739 82 GDSFILHTQPVTGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKV--STDKIETKVKTGGNISSHKGVNLPGAIVR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 167 LPGMTEKDANDIRFGIEQGIDFIAASFVRRASDVLEIKQLLEDNNASHIHIIPKIENQEGVDNIDEILEVSDGLMVARGD 246
Cdd:PRK06739 160 LPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSPNLIAKIETMEAIENFQDICKEADGIMIARGD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 247 LGVEIPAEEVPLVQKLLIKKCNTLGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQ 326
Cdd:PRK06739 240 LGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIESVS 319
|
330
....*....|
gi 671552258 327 TMNNIASRAE 336
Cdd:PRK06739 320 TLRLVSEFAE 329
|
|
| PRK08187 |
PRK08187 |
pyruvate kinase; Validated |
2-337 |
6.90e-48 |
|
pyruvate kinase; Validated
Pssm-ID: 236178 Cd Length: 493 Bit Score: 174.43 E-value: 6.90e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 2 RKTKIVCTI-GPASESVEKLTQLMEAGMNVARLNFSHGDFEEHGARIKNIREAAEITGNNIAILLDTKGPEIRTNN--MK 78
Cdd:PRK08187 133 RRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAERATGRRCKILMDLAGPKIRTGAvaGP 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 79 DGAIELVAGNDIIVSMT----EVEGTTEKFSVTYEGLIDDVDPGSKILLDDGLIGLEVTKIdkTAGEIHTKILNSGT--- 151
Cdd:PRK08187 213 LGKTRLYTGDRLALVAQgpprRIDEEHFQVTCTLPEILARLAVGARVWIDDGKLGARVERV--GPGGALLEVTHARPkgl 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 152 -LKNKKGVNVPGVAVKLPGMTEKDANDIRFGIEQGiDFIAASFVRRASDVLEIKQLLE---DNNASHIHIIPKIENQEGV 227
Cdd:PRK08187 291 kLKPEKGLNFPDTALDLPALTEKDRADLDFVARHA-DLVGYSFVQSPGDVEALQAALAarrPDDWRKLGLVLKIETPRAV 369
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 228 DNIDEILEVSDG-----LMVARGDLGVEIPAEEVPLVQKLLIKKCNTLGKPVITATQMLDSMQRNPRPTRAEASDVANAi 302
Cdd:PRK08187 370 ANLPELIVQAAGrqpfgVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTDAAMA- 448
|
330 340 350
....*....|....*....|....*....|....*
gi 671552258 303 fDGTDAIMLSgetaAGSYPVEAVQTMNNIASRAEE 337
Cdd:PRK08187 449 -ARAECVMLN----KGPYLVEAVTFLDDLLARMDG 478
|
|
| PK_C |
pfam02887 |
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ... |
358-471 |
7.49e-46 |
|
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.
Pssm-ID: 460738 [Multi-domain] Cd Length: 114 Bit Score: 157.26 E-value: 7.49e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 358 DSIGQSVAHTALNLEVKAVITPTGSGHTARMISKYRPEAPIVAVTYDASIQRQLALVWGVYPRLSQKSESTDEMLDVAVQ 437
Cdd:pfam02887 1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEAETTDEMLRRAVK 80
|
90 100 110
....*....|....*....|....*....|....
gi 671552258 438 EGVNSSIVTHGDLVVITAGLPVGEAGTTNIMKIH 471
Cdd:pfam02887 81 VAKEAGLVKKGDLVVITAGVPFGVSGTTNTLKVI 114
|
|
| PRK14725 |
PRK14725 |
pyruvate kinase; Provisional |
2-337 |
8.41e-44 |
|
pyruvate kinase; Provisional
Pssm-ID: 237804 Cd Length: 608 Bit Score: 165.12 E-value: 8.41e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 2 RKTKIVCTIgpASESVEKLT---QLMEAGMNVARLNFSHGDFEEHGARIKNIREAAEITGNNIAILLDTKGPEIRTNNMK 78
Cdd:PRK14725 139 RPTRIMVTL--PTEAADDPDlvrRLLAAGMDIARINCAHDDPEAWRAMIANVRTAEEELGRRCRIAMDLAGPKLRTGPIA 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 79 DGA--------------------IELVAGNDIIVS-------------------------MTEVEGTTEKFSVT------ 107
Cdd:PRK14725 217 PGPrviklrptrdalgrvltparLWLTASESPPPSpppgpvglpvdpewlarlepgdelrFTDARGKKRKLTVTevddeg 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 108 ---------Y--EGL----------------------------------------------------------IDDVDPG 118
Cdd:PRK14725 297 vlaegsqtaYlaNGTllrlgrhdstrvgglppveqklrlkvgdrlvltrddapgdpaqgdapparisctlpeaFRAARVG 376
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 119 SKILLDDGLIGLEVTKIdkTAGEIHTKILNSG----TLKNKKGVNVPGVAVKLPGMTEKDANDIRFGIEQGiDFIAASFV 194
Cdd:PRK14725 377 ERVWFDDGKIGAVVVKV--EADEVELRITHARpggsKLKAGKGINLPDSHLPLPALTDKDLEDLAFVAKHA-DIVALSFV 453
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 195 RRASDVLEIKQLLEDNNASHIHIIPKIENQEGVDNIDEIL-----EVSDGLMVARGDLGVEIPAEEVPLVQKLLIKKCNT 269
Cdd:PRK14725 454 RSPEDVRLLLDALEKLGADDLGVVLKIETRRAFENLPRILleamrHPRFGVMIARGDLAVEVGFERLAEVQEEILWLCEA 533
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 671552258 270 LGKPVITATQMLDSMQRNPRPTRAEASDVANAIfdGTDAIMLSgetaAGSYPVEAVQTMNNIASRAEE 337
Cdd:PRK14725 534 AHVPVIWATQVLESLAKKGLPSRAEITDAAMAL--RAECVMLN----KGPHIVEAVRVLDDILRRMEE 595
|
|
| PRK06464 |
PRK06464 |
phosphoenolpyruvate synthase; Validated |
474-581 |
2.14e-31 |
|
phosphoenolpyruvate synthase; Validated
Pssm-ID: 235809 [Multi-domain] Cd Length: 795 Bit Score: 129.87 E-value: 2.14e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 474 GDVLAKGQGIGRKTAFGKAVIATTAKEaLDKVNFGSILVTNATDRDMVPALEKCSAVIVEEGGLTSHAAVVGLNIGIPVI 553
Cdd:PRK06464 353 GKVLVEGRAIGPGIGSGKVRVILDISE-MDKVQPGDVLVTDMTDPDWEPVMKRASAIVTNRGGRTCHAAIIARELGIPAV 431
|
90 100 110
....*....|....*....|....*....|.
gi 671552258 554 VGVENATSILKDGQDITV---DSRSGYVYSG 581
Cdd:PRK06464 432 VGTGNATEVLKDGQEVTVscaEGDTGYVYEG 462
|
|
| PEP_synth |
TIGR01418 |
phosphoenolpyruvate synthase; Also called pyruvate,water dikinase and PEP synthase. The member ... |
469-581 |
9.60e-31 |
|
phosphoenolpyruvate synthase; Also called pyruvate,water dikinase and PEP synthase. The member from Methanococcus jannaschii contains a large intein. This enzyme generates phosphoenolpyruvate (PEP) from pyruvate, hydrolyzing ATP to AMP and releasing inorganic phosphate in the process. The enzyme shows extensive homology to other enzymes that use PEP as substrate or product. This enzyme may provide PEP for gluconeogenesis, for PTS-type carbohydrate transport systems, or for other processes. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273612 [Multi-domain] Cd Length: 786 Bit Score: 127.93 E-value: 9.60e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 469 KIHVIGDVLAKGQGIGRKTAFGKAVIATTAKEAlDKVNFGSILVTNATDRDMVPALEKCSAVIVEEGGLTSHAAVVGLNI 548
Cdd:TIGR01418 347 ELKGKGKVLVTGRAAGPGIASGKVKVIFDLKEM-DKFEEGDILVTDMTDPDWEPAMKRASAIVTNEGGMTCHAAIVAREL 425
|
90 100 110
....*....|....*....|....*....|....*.
gi 671552258 549 GIPVIVGVENATSILKDGQDITVD---SRSGYVYSG 581
Cdd:TIGR01418 426 GIPAVVGTGDATKTLKDGMEVTVDcaeGDTGYVYAG 461
|
|
| PpsA |
COG0574 |
Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and ... |
474-578 |
2.15e-28 |
|
Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Phosphoenolpyruvate synthase/pyruvate phosphate dikinase is part of the Pathway/BioSystem: Gluconeogenesis
Pssm-ID: 440339 [Multi-domain] Cd Length: 455 Bit Score: 118.39 E-value: 2.15e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 474 GDVLAKGQGIGRKTAFGKAVIATTAKEaLDKVNFGSILVTNATDRDMVPALEKCSAVIVEEGGLTSHAAVVGLNIGIPVI 553
Cdd:COG0574 351 GEVLAKGLPASPGAASGKVVFIADEAE-LARFQEGVILVRDETDPDDVPGMKAAAGIVTERGGMTSHAAIVARELGIPAV 429
|
90 100
....*....|....*....|....*
gi 671552258 554 VGVENATSILKDGQDITVDSRSGYV 578
Cdd:COG0574 430 VGCGDATRVLKDGDEITVDGTTGEV 454
|
|
| PEP-utilizers |
pfam00391 |
PEP-utilizing enzyme, mobile domain; This domain is a "swivelling" beta/beta/alpha domain ... |
508-576 |
3.89e-22 |
|
PEP-utilizing enzyme, mobile domain; This domain is a "swivelling" beta/beta/alpha domain which is thought to be mobile in all proteins known to contain it.
Pssm-ID: 459796 [Multi-domain] Cd Length: 73 Bit Score: 90.16 E-value: 3.89e-22
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 671552258 508 GSILVTNATDRDMVPALEKCSAVIVEEGGLTSHAAVVGLNIGIPVIVGVENATSILKDGQDITVDSRSG 576
Cdd:pfam00391 5 GVILVAPDTTPSDTAGLDKAAGIVTERGGMTSHAAIVARELGIPAVVGVGDATILLKEGDLVTVDGSTG 73
|
|
| PRK06241 |
PRK06241 |
phosphoenolpyruvate synthase; Validated |
490-578 |
2.97e-16 |
|
phosphoenolpyruvate synthase; Validated
Pssm-ID: 235751 [Multi-domain] Cd Length: 871 Bit Score: 82.63 E-value: 2.97e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 490 GKAVIATTAKEALDkvNFGSILVTNATDRDMVPALEKCSAVIVEEGGLTSHAAVVGLNIGIPVIVGVENATSILKDGQDI 569
Cdd:PRK06241 780 GRARVILNPEDADL--EKGDILVTAFTDPGWTPLFVSIKGLVTEVGGLMTHGAVIAREYGIPAVVGVENATKLIKDGQRI 857
|
....*....
gi 671552258 570 TVDSRSGYV 578
Cdd:PRK06241 858 RVDGTEGYV 866
|
|
| PRK08296 |
PRK08296 |
hypothetical protein; Provisional |
490-578 |
5.80e-15 |
|
hypothetical protein; Provisional
Pssm-ID: 181362 Cd Length: 603 Bit Score: 77.77 E-value: 5.80e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 490 GKAVIATTAKEaLDKVNFGSILVTNATDRDMVPALEKCSAVIVEEGGLTSHAAVVGLNIGIPVIVGVENATSILKDGQDI 569
Cdd:PRK08296 512 GPARVIRSADE-LSEVQEGEILVCPVTSPSWAPIFAKIKATVTDIGGVMSHAAIVCREYGLPAVVGTGNATKRIKTGQRL 590
|
....*....
gi 671552258 570 TVDSRSGYV 578
Cdd:PRK08296 591 RVDGTKGVV 599
|
|
| PRK05878 |
PRK05878 |
pyruvate phosphate dikinase; Provisional |
476-581 |
6.93e-13 |
|
pyruvate phosphate dikinase; Provisional
Pssm-ID: 235635 [Multi-domain] Cd Length: 530 Bit Score: 71.31 E-value: 6.93e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671552258 476 VLAKGQGIGRKTAFGKAViaTTAKEALDKVNFGS--ILVTNATDRDMVPALEKCSAVIVEEGGLTSHAAVVGLNIGIPVI 553
Cdd:PRK05878 349 LLAKGLPACPGVVSGTAY--TDVDEALDAADRGEpvILVRDHTRPDDVHGMLAAQGIVTEVGGATSHAAVVSRELGRVAV 426
|
90 100
....*....|....*....|....*...
gi 671552258 554 VGVENATSILKDGQDITVDSRSGYVYSG 581
Cdd:PRK05878 427 VGCGAGVAAALAGKEITVDGYEGEVRQG 454
|
|
| PRK05865 |
PRK05865 |
sugar epimerase family protein; |
500-578 |
4.91e-09 |
|
sugar epimerase family protein;
Pssm-ID: 235630 [Multi-domain] Cd Length: 854 Bit Score: 59.29 E-value: 4.91e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 671552258 500 EALDKVNFGSILVTNATDRDMVPALEKCSAVIVEEGGLTSHAAVVGLNIGIPVIVGVENATSILKDGQDITVDSRSGYV 578
Cdd:PRK05865 756 ETIDDLQPGEILVAEVTDVGYTAAFCYAAAVVTELGGPMSHAAVVAREFGFPCVVDAQGATRFLPPGALVEVDGATGEI 834
|
|
| PtsA |
COG1080 |
Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate ... |
508-579 |
2.59e-08 |
|
Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism];
Pssm-ID: 440698 [Multi-domain] Cd Length: 571 Bit Score: 56.62 E-value: 2.59e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 671552258 508 GSILVTnatdRDMVPA------LEKCSAVIVEEGGLTSHAAVVGLNIGIPVIVGVENATSILKDGQDITVDSRSGYVY 579
Cdd:COG1080 154 PVILVA----HDLTPSdtaqldPSRVAGFVTDLGGRTSHTAILARSLGIPAVVGLGDALLLVKDGDLVIVDGDAGVVI 227
|
|
| PRK11061 |
PRK11061 |
phosphoenolpyruvate--protein phosphotransferase; |
510-579 |
4.84e-03 |
|
phosphoenolpyruvate--protein phosphotransferase;
Pssm-ID: 182937 [Multi-domain] Cd Length: 748 Bit Score: 39.98 E-value: 4.84e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 671552258 510 ILVTNATDRDMVPAL--EKCSAVIVEEGGLTSHAAVVGLNIGIPVIVGVENATSILKDGQDItVDSRSGYVY 579
Cdd:PRK11061 324 ILVADELTATLLAELpqDRLAGVVVRDGAANSHAAILVRALGIPTVMGADIQPSLLHQRLLI-VDGYRGELL 394
|
|
| PRK11177 |
PRK11177 |
phosphoenolpyruvate-protein phosphotransferase PtsI; |
510-579 |
6.21e-03 |
|
phosphoenolpyruvate-protein phosphotransferase PtsI;
Pssm-ID: 183017 [Multi-domain] Cd Length: 575 Bit Score: 39.61 E-value: 6.21e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 671552258 510 ILVTNatdrDMVPA------LEKCSAVIVEEGGLTSHAAVVGLNIGIPVIVGVENATSILKDGQDITVDSRSGYVY 579
Cdd:PRK11177 157 ILVAA----DLTPSetaqlnLKKVLGFITDIGGRTSHTSIMARSLELPAIVGTGNITKQVKNGDYLILDAVNNQIY 228
|
|
| PRK10558 |
PRK10558 |
alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional |
214-247 |
8.86e-03 |
|
alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional
Pssm-ID: 182547 Cd Length: 256 Bit Score: 38.18 E-value: 8.86e-03
10 20 30
....*....|....*....|....*....|....*.
gi 671552258 214 HIHIIPKIENQEGVDNIDEILEVS--DGLMVARGDL 247
Cdd:PRK10558 145 NITVLVQIESQQGVDNVDAIAATEgvDGIFVGPSDL 180
|
|
| |
