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Conserved domains on  [gi|671623493|ref|WP_031589997|]
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class I SAM-dependent methyltransferase [Kandleria vitulina]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10789277)

class I SAM-dependent methyltransferase is an enzyme that uses S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyl transfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047
PubMed:  12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 77-199 5.39e-15

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 69.25  E-value: 5.39e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671623493  77 ARSLMKRLSIKDKKcTVLDLGCKKGFTSILLAKNKRALIkSVDINDE----CRSHLKEAKVNkrVEAIASPLTSLPFKDE 152
Cdd:COG2226   11 REALLAALGLRPGA-RVLDLGCGTGRLALALAERGARVT-GVDISPEmlelARERAAEAGLN--VEFVVGDAEDLPFPDG 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 671623493 153 TFDYVYS-----FFPskkDSTDIIKEGLRVLKKNGYIAF-EGHCEDVSSFEEL 199
Cdd:COG2226   87 SFDLVISsfvlhHLP---DPERALAEIARVLKPGGRLVVvDFSPPDLAELEEL 136
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 77-199 5.39e-15

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 69.25  E-value: 5.39e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671623493  77 ARSLMKRLSIKDKKcTVLDLGCKKGFTSILLAKNKRALIkSVDINDE----CRSHLKEAKVNkrVEAIASPLTSLPFKDE 152
Cdd:COG2226   11 REALLAALGLRPGA-RVLDLGCGTGRLALALAERGARVT-GVDISPEmlelARERAAEAGLN--VEFVVGDAEDLPFPDG 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 671623493 153 TFDYVYS-----FFPskkDSTDIIKEGLRVLKKNGYIAF-EGHCEDVSSFEEL 199
Cdd:COG2226   87 SFDLVISsfvlhHLP---DPERALAEIARVLKPGGRLVVvDFSPPDLAELEEL 136
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 93-182 9.31e-14

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 64.89  E-value: 9.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671623493   93 VLDLGCKKGFTSILLAKNKRALIKSVDINDE----CRSHLKEAKVNkrVEAIASPLTSLPFKDETFDYVYSFFP----SK 164
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEmlerARERAAEAGLN--VEFVQGDAEDLPFPDGSFDLVVSSGVlhhlPD 78

                          90
                  ....*....|....*...
gi 671623493  165 KDSTDIIKEGLRVLKKNG 182
Cdd:pfam13649  79 PDLEAALREIARVLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 92-187 1.38e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 56.67  E-value: 1.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671623493  92 TVLDLGCKKGFTSILLAKNKRALIKSVDINDECRSHLKEA---KVNKRVEAIASPLTSLPF-KDETFDYVYS---FFPSK 164
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAaaaLLADNVEVLKGDAEELPPeADESFDVIISdppLHHLV 80

                         90       100
                 ....*....|....*....|...
gi 671623493 165 KDSTDIIKEGLRVLKKNGYIAFE 187
Cdd:cd02440   81 EDLARFLEEARRLLKPGGVLVLT 103
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 75-185 4.11e-06

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 46.30  E-value: 4.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671623493  75 HKA--RSLMKRLSIKDKKcTVLDLGCKKGFTSILLAK--NKRALIKSVDINDE----CRSHLKEAKVNKRVEAIASPLTS 146
Cdd:PRK00216  36 HRVwrRKTIKWLGVRPGD-KVLDLACGTGDLAIALAKavGKTGEVVGLDFSEGmlavGREKLRDLGLSGNVEFVQGDAEA 114

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 671623493 147 LPFKDETFDYV-YSF----FPSKKDStdiIKEGLRVLKKNGYIA 185
Cdd:PRK00216 115 LPFPDNSFDAVtIAFglrnVPDIDKA---LREMYRVLKPGGRLV 155
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 93-186 1.17e-04

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 41.89  E-value: 1.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671623493   93 VLDLGCKKG-FTSILLAKNKRALIKSVDINDECRSHLKEaKVNKRVEAIASPLTSLPFKDETFDYVYS-----FFpskKD 166
Cdd:TIGR02072  38 VLDIGCGTGyLTRALLKRFPQAEFIALDISAGMLAQAKT-KLSENVQFICGDAEKLPLEDSSFDLIVSnlalqWC---DD 113

                          90       100
                  ....*....|....*....|
gi 671623493  167 STDIIKEGLRVLKKNGYIAF 186
Cdd:TIGR02072 114 LSQALSELARVLKPGGLLAF 133
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 77-199 5.39e-15

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 69.25  E-value: 5.39e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671623493  77 ARSLMKRLSIKDKKcTVLDLGCKKGFTSILLAKNKRALIkSVDINDE----CRSHLKEAKVNkrVEAIASPLTSLPFKDE 152
Cdd:COG2226   11 REALLAALGLRPGA-RVLDLGCGTGRLALALAERGARVT-GVDISPEmlelARERAAEAGLN--VEFVVGDAEDLPFPDG 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 671623493 153 TFDYVYS-----FFPskkDSTDIIKEGLRVLKKNGYIAF-EGHCEDVSSFEEL 199
Cdd:COG2226   87 SFDLVISsfvlhHLP---DPERALAEIARVLKPGGRLVVvDFSPPDLAELEEL 136
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 93-182 9.31e-14

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 64.89  E-value: 9.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671623493   93 VLDLGCKKGFTSILLAKNKRALIKSVDINDE----CRSHLKEAKVNkrVEAIASPLTSLPFKDETFDYVYSFFP----SK 164
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEmlerARERAAEAGLN--VEFVQGDAEDLPFPDGSFDLVVSSGVlhhlPD 78

                          90
                  ....*....|....*...
gi 671623493  165 KDSTDIIKEGLRVLKKNG 182
Cdd:pfam13649  79 PDLEAALREIARVLKPGG 96
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 94-186 2.93e-13

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 63.45  E-value: 2.93e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671623493   94 LDLGCKKGFTSILLAKNKRALIkSVDINDECRSHLKEAKVNKRVEAIASPLTSLPFKDETFDYVYSF--FPSKKDSTDII 171
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVT-GVDISPEMLELAREKAPREGLTFVVGDAEDLPFPDNSFDLVLSSevLHHVEDPERAL 79

                          90
                  ....*....|....*
gi 671623493  172 KEGLRVLKKNGYIAF 186
Cdd:pfam08241  80 REIARVLKPGGILII 94
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 74-187 3.30e-11

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 58.88  E-value: 3.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671623493  74 DHKARSLMKRLSIKDKKctVLDLGCKKGFTSILLAKnKRALIKSVDINDECRSHLKEAKVNKRVEAIASPLTSLPFKDET 153
Cdd:COG2227   11 DRRLAALLARLLPAGGR--VLDVGCGTGRLALALAR-RGADVTGVDISPEALEIARERAAELNVDFVQGDLEDLPLEDGS 87

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 671623493 154 FDYVYSF-----FPskkDSTDIIKEGLRVLKKNGYIAFE 187
Cdd:COG2227   88 FDLVICSevlehLP---DPAALLRELARLLKPGGLLLLS 123
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 92-187 1.38e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 56.67  E-value: 1.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671623493  92 TVLDLGCKKGFTSILLAKNKRALIKSVDINDECRSHLKEA---KVNKRVEAIASPLTSLPF-KDETFDYVYS---FFPSK 164
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAaaaLLADNVEVLKGDAEELPPeADESFDVIISdppLHHLV 80

                         90       100
                 ....*....|....*....|...
gi 671623493 165 KDSTDIIKEGLRVLKKNGYIAFE 187
Cdd:cd02440   81 EDLARFLEEARRLLKPGGVLVLT 103
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 87-203 2.62e-08

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 51.26  E-value: 2.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671623493   87 KDKKCTVLDLGCKKGFTSILLAK--NKRALIKSVDINDE----CRSHLKEAKVnKRVEAIASPLTSLP--FKDETFDYVY 158
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEelGPNAEVVGIDISEEaiekARENAQKLGF-DNVEFEQGDIEELPelLEDDKFDVVI 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 671623493  159 SF--FPSKKDSTDIIKEGLRVLKKNGYIAfeghCEDVSSFEELGLHV 203
Cdd:pfam13847  80 SNcvLNHIPDPDKVLQEILRVLKPGGRLI----ISDPDSLAELPAHV 122
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 74-186 6.12e-08

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 50.31  E-value: 6.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671623493  74 DHKARSLMKRLSIKDKKcTVLDLGCKKGFTSILLAKNKRALIKSVDINDE----CRSHLKEAKVNKRVEAIASPLTSLPF 149
Cdd:COG2230   37 EAKLDLILRKLGLKPGM-RVLDIGCGWGGLALYLARRYGVRVTGVTLSPEqleyARERAAEAGLADRVEVRLADYRDLPA 115

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 671623493 150 kDETFDYVYSF-----FPsKKDSTDIIKEGLRVLKKNGYIAF 186
Cdd:COG2230  116 -DGQFDAIVSIgmfehVG-PENYPAYFAKVARLLKPGGRLLL 155
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 88-189 2.75e-07

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 49.53  E-value: 2.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671623493  88 DKKCTVLDLGCKKGFTSILLAKNKRALIKSVDINDE----CRSHLKEAKVnKRVEAIASPLT-SLPFKDETFDYVYSF-- 160
Cdd:COG0500   25 PKGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSPEaialARARAAKAGL-GNVEFLVADLAeLDPLPAESFDLVVAFgv 103

                         90       100       110
                 ....*....|....*....|....*....|.
gi 671623493 161 --FPSKKDSTDIIKEGLRVLKKNGYIAFEGH 189
Cdd:COG0500  104 lhHLPPEEREALLRELARALKPGGVLLLSAS 134
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 75-185 4.11e-06

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 46.30  E-value: 4.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671623493  75 HKA--RSLMKRLSIKDKKcTVLDLGCKKGFTSILLAK--NKRALIKSVDINDE----CRSHLKEAKVNKRVEAIASPLTS 146
Cdd:PRK00216  36 HRVwrRKTIKWLGVRPGD-KVLDLACGTGDLAIALAKavGKTGEVVGLDFSEGmlavGREKLRDLGLSGNVEFVQGDAEA 114

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 671623493 147 LPFKDETFDYV-YSF----FPSKKDStdiIKEGLRVLKKNGYIA 185
Cdd:PRK00216 115 LPFPDNSFDAVtIAFglrnVPDIDKA---LREMYRVLKPGGRLV 155
PRK14968 PRK14968
putative methyltransferase; Provisional
 80-155 1.80e-05

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 43.73  E-value: 1.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671623493  80 LMKRLSIKDKKcTVLDLGCKKGFTSILLAKNKRALIkSVDINDE-CRSHLKEAKVN----KRVEAIASPLTSlPFKDETF 154
Cdd:PRK14968  15 LAENAVDKKGD-RVLEVGTGSGIVAIVAAKNGKKVV-GVDINPYaVECAKCNAKLNnirnNGVEVIRSDLFE-PFRGDKF 91


                 .
gi 671623493 155 D 155
Cdd:PRK14968  92 D 92
PLN02490 PLN02490
MPBQ/MSBQ methyltransferase
 88-182 3.17e-05

MPBQ/MSBQ methyltransferase


Pssm-ID: 215270 [Multi-domain]  Cd Length: 340  Bit Score: 44.11  E-value: 3.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671623493  88 DKKCTVLDLGCKKGFTSILLAKNKRAliKSVDINDECRSHLKEAKVN---KRVEAIASPLTSLPFKDETFD-YVYS---- 159
Cdd:PLN02490 112 DRNLKVVDVGGGTGFTTLGIVKHVDA--KNVTILDQSPHQLAKAKQKeplKECKIIEGDAEDLPFPTDYADrYVSAgsie 189

                         90       100
                 ....*....|....*....|...
gi 671623493 160 FFPskkDSTDIIKEGLRVLKKNG 182
Cdd:PLN02490 190 YWP---DPQRGIKEAYRVLKIGG 209
PRK08317 PRK08317
hypothetical protein; Provisional
 92-184 4.85e-05

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 43.00  E-value: 4.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671623493  92 TVLDLGCKKGFTSILLAK--NKRALIKSVDINDecrSHLKEAKvnKRVEAIASPL-------TSLPFKDETFDYVYS--F 160
Cdd:PRK08317  22 RVLDVGCGPGNDARELARrvGPEGRVVGIDRSE---AMLALAK--ERAAGLGPNVefvrgdaDGLPFPDGSFDAVRSdrV 96

                         90       100
                 ....*....|....*....|....
gi 671623493 161 FPSKKDSTDIIKEGLRVLKKNGYI 184
Cdd:PRK08317  97 LQHLEDPARALAEIARVLRPGGRV 120
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 93-186 1.17e-04

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 41.89  E-value: 1.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671623493   93 VLDLGCKKG-FTSILLAKNKRALIKSVDINDECRSHLKEaKVNKRVEAIASPLTSLPFKDETFDYVYS-----FFpskKD 166
Cdd:TIGR02072  38 VLDIGCGTGyLTRALLKRFPQAEFIALDISAGMLAQAKT-KLSENVQFICGDAEKLPLEDSSFDLIVSnlalqWC---DD 113

                          90       100
                  ....*....|....*....|
gi 671623493  167 STDIIKEGLRVLKKNGYIAF 186
Cdd:TIGR02072 114 LSQALSELARVLKPGGLLAF 133
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
 92-198 1.39e-04

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 42.16  E-value: 1.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671623493  92 TVLDLGCKKGFTSILLAKNKRALIKSVDINDECRSHLKE-AKVNK---RVEAIASPLTSLPF-KDETFDYVYSFFPskKD 166
Cdd:COG2520  183 RVLDMFAGVGPFSIPIAKRSGAKVVAIDINPDAVEYLKEnIRLNKvedRVTPILGDAREVAPeLEGKADRIIMNLP--HS 260

                         90       100       110
                 ....*....|....*....|....*....|..
gi 671623493 167 STDIIKEGLRVLKKNGYIAFEGHCEDVSSFEE 198
Cdd:COG2520  261 ADEFLDAALRALKPGGVIHYYEIVPEEDPFER 292
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 71-195 8.60e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 38.56  E-value: 8.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671623493   71 SILDHKARSLMKRLS-IKDKKCTVLDLGCKKGFTSILLAKNkRALIKSVDINDECRSHLKEAKVNKRVEAIaspltSLPF 149
Cdd:pfam13489   3 HQRERLLADLLLRLLpKLPSPGRVLDFGCGTGIFLRLLRAQ-GFSVTGVDPSPIAIERALLNVRFDQFDEQ-----EAAV 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 671623493  150 KDETFDYVYSF--FPSKKDSTDIIKEGLRVLKKNGYIAFEGHCEDVSS 195
Cdd:pfam13489  77 PAGKFDVIVARevLEHVPDPPALLRQIAALLKPGGLLLLSTPLASDEA 124
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
92-206 8.70e-04

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 39.34  E-value: 8.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671623493   92 TVLDLGCKKGFTSILLAKN--KRALIKSVDIND----ECRSHLKEAKVnKRVEAIASPLTSLPFKDETFDYVYSFFPSKK 165
Cdd:pfam01209  45 KFLDVAGGTGDWTFGLSDSagSSGKVVGLDINEnmlkEGEKKAKEEGK-YNIEFLQGNAEELPFEDDSFDIVTISFGLRN 123

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 671623493  166 --DSTDIIKEGLRVLKKNGYIafegHCEDVSSFEELGLHVIYD 206
Cdd:pfam01209 124 fpDYLKVLKEAFRVLKPGGRV----VCLEFSKPENPLLSQAYE 162
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 73-182 1.09e-03

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 38.34  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671623493   73 LDHKARSLMKRLSiKDKKCTVLDLGCKKGFTSILLAK-NKRALIKSVDIN----DECRSHLKEAKVnKRVEAIASPLTSl 147
Cdd:pfam05175  16 LDIGSRLLLEHLP-KDLSGKVLDLGCGAGVLGAALAKeSPDAELTMVDINaralESARENLAANGL-ENGEVVASDVYS- 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 671623493  148 PFKDETFDYVYS---FFPSKKDSTD----IIKEGLRVLKKNG 182
Cdd:pfam05175  93 GVEDGKFDLIISnppFHAGLATTYNvaqrFIADAKRHLRPGG 134
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 73-182 2.68e-03

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 37.48  E-value: 2.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671623493  73 LDHKARSLMKRLSIKDKKcTVLDLGCKKGFTSILLAK-NKRALIKSVDIN----DECRSHLKEAKVNkRVEAIASPLTSl 147
Cdd:COG2813   34 LDIGTRLLLEHLPEPLGG-RVLDLGCGYGVIGLALAKrNPEARVTLVDVNaravELARANAAANGLE-NVEVLWSDGLS- 110

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 671623493 148 PFKDETFDYVYS---FFPSKKDSTDI----IKEGLRVLKKNG 182
Cdd:COG2813  111 GVPDGSFDLILSnppFHAGRAVDKEVahalIADAARHLRPGG 152
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 92-186 3.55e-03

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 37.43  E-value: 3.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671623493  92 TVLDLGCKKGFTSILLA-KNKRALIKSVDINDE----CRSHLKEAKVNKRVEAIASPLTSLP--FKDETFDYVYS---FF 161
Cdd:COG4123   40 RVLDLGTGTGVIALMLAqRSPGARITGVEIQPEaaelARRNVALNGLEDRITVIHGDLKEFAaeLPPGSFDLVVSnppYF 119

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 671623493 162 PSKKDST------------------DIIKEGLRVLKKNGYIAF 186
Cdd:COG4123  120 KAGSGRKspdearaiarhedaltleDLIRAAARLLKPGGRFAL 162
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 89-157 5.27e-03

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 37.12  E-value: 5.27e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 671623493  89 KKCTVLDLGCKKGFTSILLAKNKrALIKSVDIN----DECRSHLKEAKVNKRVEAIASPLTSLpfkDETFDYV 157
Cdd:PRK07580  63 TGLRILDAGCGVGSLSIPLARRG-AKVVASDISpqmvEEARERAPEAGLAGNITFEVGDLESL---LGRFDTV 131
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
75-186 5.73e-03

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 36.51  E-value: 5.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671623493  75 HKARSLMKRLSIkDKKCTVLDLGCKKGFTSILLAKNKRALIkSVDINDECRSHLKEAKVNKRVEAIAspLTSLPFKDETF 154
Cdd:COG4976   33 LLAEELLARLPP-GPFGRVLDLGCGTGLLGEALRPRGYRLT-GVDLSEEMLAKAREKGVYDRLLVAD--LADLAEPDGRF 108

                         90       100       110
                 ....*....|....*....|....*....|....
gi 671623493 155 DYVYSF--FPSKKDSTDIIKEGLRVLKKNGYIAF 186
Cdd:COG4976  109 DLIVAAdvLTYLGDLAAVFAGVARALKPGGLFIF 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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