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Conserved domains on  [gi|690991084|ref|WP_031961561|]
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TetR/AcrR family transcriptional regulator [Acinetobacter baumannii]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442015)

TetR/AcrR family transcriptional regulator may control genes involved in one of a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.10.60|1.10.357.10
Gene Ontology:  GO:0003700|GO:0003677|GO:0006355
PubMed:  23602932
SCOP:  4000333

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
9-157 6.11e-17

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 74.55  E-value: 6.11e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 690991084   9 RPKDLEKRARILQAAKAIFLKSGYHGTSMNLIAQEAGVTKLTVYNHFQDKANLFIcAITETCEETLGTKPFELDASADFY 88
Cdd:COG1309    1 RRRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLL-AVLERLLEELLAALEEALAAEDPR 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 690991084  89 QTLYMVCSRALQIIYSPEALKLehVLFELAAEQSPLAlQFFNASHTRLQNQLVEFFQKAAQLGFIQADD 157
Cdd:COG1309   80 ERLRALLRAYLEFLAENPALAR--LLLAEAAELPELR-AALRALLRRLRALLAELLRAGGLLADVDPDA 145
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
9-157 6.11e-17

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 74.55  E-value: 6.11e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 690991084   9 RPKDLEKRARILQAAKAIFLKSGYHGTSMNLIAQEAGVTKLTVYNHFQDKANLFIcAITETCEETLGTKPFELDASADFY 88
Cdd:COG1309    1 RRRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLL-AVLERLLEELLAALEEALAAEDPR 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 690991084  89 QTLYMVCSRALQIIYSPEALKLehVLFELAAEQSPLAlQFFNASHTRLQNQLVEFFQKAAQLGFIQADD 157
Cdd:COG1309   80 ERLRALLRAYLEFLAENPALAR--LLLAEAAELPELR-AALRALLRRLRALLAELLRAGGLLADVDPDA 145
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
19-62 1.98e-10

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 53.95  E-value: 1.98e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 690991084   19 ILQAAKAIFLKSGYHGTSMNLIAQEAGVTKLTVYNHFQDKANLF 62
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELL 44
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 13-68 5.96e-09

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 53.86  E-value: 5.96e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 690991084  13 LEKRARILQAAKAIFLKSGYHGTSMNLIAQEAGVTKLTVYNHFQDKANLF--ICAITE 68
Cdd:PRK10668  10 QETRQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDLFseIWELSE 67
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
16-61 9.76e-09

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 52.98  E-value: 9.76e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 690991084  16 RARILQAAKAIFLKSGYHGTSMNLIAQEAGVTKLTVYNHFQDKANL 61
Cdd:NF041196   8 RRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEAL 53
DHAK_reg TIGR02366
probable dihydroxyacetone kinase regulator; The seed alignment for this family was built from ...
 19-94 7.92e-04

probable dihydroxyacetone kinase regulator; The seed alignment for this family was built from a set of closely related uncharacterized proteins associated with operons for the type of bacterial dihydroxyacetone kinase that transfers PEP-derived phosphate from a phosphoprotein, as in phosphotransferase system transport, rather than from ATP. Members have a TetR transcriptional regulator domain (pfam00440) at the N-terminus and sequence homology throughout.


Pssm-ID: 274100 [Multi-domain]  Cd Length: 176  Bit Score: 38.59  E-value: 7.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 690991084   19 ILQAAKAIFLKSGYHGTSMNLIAQEAGVTKLTVYNHFQDKANL----FICAITETCEETLGTKP---------FELDASA 85
Cdd:TIGR02366   8 IAKAFKDLMEVQAFHKISVSDIMQTAQIRRQTFYNHFQDKYELlswiFETELKEQVIDNLDYISwqnildlllRYFDENQ 87


                  ....*....
gi 690991084   86 DFYQTLYMV 94
Cdd:TIGR02366  88 TFYQKAFVI 96
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
9-157 6.11e-17

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 74.55  E-value: 6.11e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 690991084   9 RPKDLEKRARILQAAKAIFLKSGYHGTSMNLIAQEAGVTKLTVYNHFQDKANLFIcAITETCEETLGTKPFELDASADFY 88
Cdd:COG1309    1 RRRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLL-AVLERLLEELLAALEEALAAEDPR 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 690991084  89 QTLYMVCSRALQIIYSPEALKLehVLFELAAEQSPLAlQFFNASHTRLQNQLVEFFQKAAQLGFIQADD 157
Cdd:COG1309   80 ERLRALLRAYLEFLAENPALAR--LLLAEAAELPELR-AALRALLRRLRALLAELLRAGGLLADVDPDA 145
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
19-62 1.98e-10

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 53.95  E-value: 1.98e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 690991084   19 ILQAAKAIFLKSGYHGTSMNLIAQEAGVTKLTVYNHFQDKANLF 62
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELL 44
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 13-68 5.96e-09

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 53.86  E-value: 5.96e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 690991084  13 LEKRARILQAAKAIFLKSGYHGTSMNLIAQEAGVTKLTVYNHFQDKANLF--ICAITE 68
Cdd:PRK10668  10 QETRQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDLFseIWELSE 67
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
16-61 9.76e-09

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 52.98  E-value: 9.76e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 690991084  16 RARILQAAKAIFLKSGYHGTSMNLIAQEAGVTKLTVYNHFQDKANL 61
Cdd:NF041196   8 RRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEAL 53
TetR_C_7 pfam14246
AefR-like transcriptional repressor, C-terminal domain; This family comprises the C-terminal ...
 99-206 2.01e-06

AefR-like transcriptional repressor, C-terminal domain; This family comprises the C-terminal domain of transcriptional regulators of the TetR family. It includes the AefR transcriptional regulator from P. syringae. It is found in association with pfam00440.


Pssm-ID: 433807  Cd Length: 119  Bit Score: 45.24  E-value: 2.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 690991084   99 LQIIYSPEALKLEHVLFElAAEQSP-LALQFFNASHTRLQNQLVEFFQKAAQLGFIQADDPLYQTELLLTLLLGVRHHKI 177
Cdd:pfam14246  11 LALLTSPDGIALFRLVIA-EAERFPeLGRAFYEAGPGRGLEALADYLEAAVAAGRLRIDDPELAAEQFLGLLKGFLFWPR 89

                          90       100
                  ....*....|....*....|....*....
gi 690991084  178 LLRIIPVPNAQEIDRFIRDAIDLFLLKYR 206
Cdd:pfam14246  90 LFGGDPPPSPAEIDRVVDSAVDMFLAAYG 118
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
9-147 2.46e-06

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 46.08  E-value: 2.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 690991084   9 RPKDLEKRARILQAAKAIFLKSGYHGTSMNLIAQEAGVTKLTVYNHFQDKANLfICAITETCEETLGTKPFELDASADfy 88
Cdd:COG3226    3 RRRGEERRERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDEL-LAAAFERLAEREAARLRALLAAAD-- 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 690991084  89 qTLYMVCSRALQIIY-----SPEALKLEHVLFELAAEQSPLAlQFFNASHTRLQNQLVEFFQKA 147
Cdd:COG3226   80 -DLEDAAEALADLLAellpaDRDRLLARYELYLEALRDPELR-ALLRRWRDRLREALARLLAAL 141
PRK14996 PRK14996
TetR family transcriptional regulator; Provisional
 14-63 2.35e-05

TetR family transcriptional regulator; Provisional


Pssm-ID: 184958 [Multi-domain]  Cd Length: 192  Bit Score: 43.16  E-value: 2.35e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 690991084  14 EKRARILQAAKAIFLKSGYHGTSMNLIAQEAGVTKLTVYNHFQD----KANLFI 63
Cdd:PRK14996   8 ERREVILQAAMRVALAEGFAAMTVRRIASEAQVAAGQVHHHFSSagelKALAFI 61
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
 13-62 8.15e-05

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 42.03  E-value: 8.15e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 690991084  13 LEKRARILQAAKAIFLKSGYHGTSMNLIAQEAGVTKLTVYNHFQDKANLF 62
Cdd:PRK09975  10 LKTRQELIETAIAQFALRGVSNTTLNDIADAANVTRGAIYWHFENKTQLF 59
PRK15008 PRK15008
HTH-type transcriptional regulator RutR; Provisional
 15-63 7.56e-04

HTH-type transcriptional regulator RutR; Provisional


Pssm-ID: 184970 [Multi-domain]  Cd Length: 212  Bit Score: 39.14  E-value: 7.56e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 690991084  15 KRARILQAAKAIFLKSGYHGTSMNLIAQEAGVTKLTVYNHFQDKANLFI 63
Cdd:PRK15008  19 KKKAILSAALDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYI 67
DHAK_reg TIGR02366
probable dihydroxyacetone kinase regulator; The seed alignment for this family was built from ...
 19-94 7.92e-04

probable dihydroxyacetone kinase regulator; The seed alignment for this family was built from a set of closely related uncharacterized proteins associated with operons for the type of bacterial dihydroxyacetone kinase that transfers PEP-derived phosphate from a phosphoprotein, as in phosphotransferase system transport, rather than from ATP. Members have a TetR transcriptional regulator domain (pfam00440) at the N-terminus and sequence homology throughout.


Pssm-ID: 274100 [Multi-domain]  Cd Length: 176  Bit Score: 38.59  E-value: 7.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 690991084   19 ILQAAKAIFLKSGYHGTSMNLIAQEAGVTKLTVYNHFQDKANL----FICAITETCEETLGTKP---------FELDASA 85
Cdd:TIGR02366   8 IAKAFKDLMEVQAFHKISVSDIMQTAQIRRQTFYNHFQDKYELlswiFETELKEQVIDNLDYISwqnildlllRYFDENQ 87


                  ....*....
gi 690991084   86 DFYQTLYMV 94
Cdd:TIGR02366  88 TFYQKAFVI 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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