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Conserved domains on  [gi|691029546|ref|WP_031986007|]
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MULTISPECIES: ComEA family DNA-binding protein [Acinetobacter calcoaceticus/baumannii complex]

Protein Classification

ComEA family DNA-binding protein( domain architecture ID 11446237)

ComEA family DNA-binding protein contains a helix-hairpin-helix (HhH) motif, similar to Bacillus subtilis ComE operon protein 1, an integral membrane protein required for both DNA binding and transport

Gene Ontology:  GO:0003677
PubMed:  10908318|8692686
SCOP:  4001398

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ComEA COG1555
DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair]; ...
 72-134 1.99e-27

DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair];


:

Pssm-ID: 441164 [Multi-domain]  Cd Length: 72  Bit Score: 96.47  E-value: 1.99e-27
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 691029546  72 STGQIHLNQANVNEFQQLKGIGEKKAQAIVEYRQKNGSFKNIDEIKNVKGIGPAIFEKNKSRL 134
Cdd:COG1555    9 AGGKVDINTATAEELQTLPGIGPKLAQRIVEYREKNGPFKSVEDLLEVKGIGPKTLEKLKPYL 71
 
Name Accession Description Interval E-value
ComEA COG1555
DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair]; ...
 72-134 1.99e-27

DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair];


Pssm-ID: 441164 [Multi-domain]  Cd Length: 72  Bit Score: 96.47  E-value: 1.99e-27
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 691029546  72 STGQIHLNQANVNEFQQLKGIGEKKAQAIVEYRQKNGSFKNIDEIKNVKGIGPAIFEKNKSRL 134
Cdd:COG1555    9 AGGKVDINTATAEELQTLPGIGPKLAQRIVEYREKNGPFKSVEDLLEVKGIGPKTLEKLKPYL 71
HHH_3 pfam12836
Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.
 75-134 2.69e-20

Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.


Pssm-ID: 463723 [Multi-domain]  Cd Length: 62  Bit Score: 78.29  E-value: 2.69e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 691029546   75 QIHLNQANVNEFQQLKGIGEKKAQAIVEYRQKNGSFKNIDEIKNVKGIGPAIFEKNKSRL 134
Cdd:pfam12836   3 GVDINTASAELLSRVPGLGPKLAKNIVEYREENGPFRSREDLLKVKGLGPKTFEQLAGFL 62
comE TIGR01259
comEA protein; This model describes the ComEA protein in bacteria. The com E locus is ...
 72-136 5.45e-20

comEA protein; This model describes the ComEA protein in bacteria. The com E locus is obligatory for bacterial cell competence - the process of internalizing the exogenous added DNA. Lesions in the loci has been variously described for the appearance of competence-related pheonotypes and impairment of competence, suggesting their intimate functional role in bacterial transformation. [Cellular processes, DNA transformation]


Pssm-ID: 213597 [Multi-domain]  Cd Length: 120  Bit Score: 79.18  E-value: 5.45e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 691029546   72 STGQIHLNQANVNEFQQLKGIGEKKAQAIVEYRQKNGSFKNIDEIKNVKGIGPAIFEKNKSRLAL 136
Cdd:TIGR01259  56 KLAAVNINAASLEELQALPGIGPAKAKAIIEYREENGAFKSVDDLTKVSGIGEKSLEKLKDYATV 120
psbU PRK02515
photosystem II complex extrinsic protein PsbU;
13-131 9.16e-06

photosystem II complex extrinsic protein PsbU;


Pssm-ID: 235048 [Multi-domain]  Cd Length: 132  Bit Score: 42.36  E-value: 9.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691029546  13 FVLIILCLG--VISPSVYAQsfdqNFQEWKAKQQIYDQKLNitksshsngskisqtknfnDSTGQIHLNQANVNEFQQLK 90
Cdd:PRK02515  11 FSLLLGLLGwlGTPQSAQAA----ELPLLAVPQNVADAKLG-------------------EFGEKIDLNNSSVRAFRQFP 67

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 691029546  91 GIGEKKAQAIVeyrqKNGSFKNIDEIKNVKGIG---PAIFEKNK 131
Cdd:PRK02515  68 GMYPTLAGKIV----KNAPYDSVEDVLNLPGLSerqKELLEANL 107
 
Name Accession Description Interval E-value
ComEA COG1555
DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair]; ...
 72-134 1.99e-27

DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair];


Pssm-ID: 441164 [Multi-domain]  Cd Length: 72  Bit Score: 96.47  E-value: 1.99e-27
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 691029546  72 STGQIHLNQANVNEFQQLKGIGEKKAQAIVEYRQKNGSFKNIDEIKNVKGIGPAIFEKNKSRL 134
Cdd:COG1555    9 AGGKVDINTATAEELQTLPGIGPKLAQRIVEYREKNGPFKSVEDLLEVKGIGPKTLEKLKPYL 71
HHH_3 pfam12836
Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.
 75-134 2.69e-20

Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.


Pssm-ID: 463723 [Multi-domain]  Cd Length: 62  Bit Score: 78.29  E-value: 2.69e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 691029546   75 QIHLNQANVNEFQQLKGIGEKKAQAIVEYRQKNGSFKNIDEIKNVKGIGPAIFEKNKSRL 134
Cdd:pfam12836   3 GVDINTASAELLSRVPGLGPKLAKNIVEYREENGPFRSREDLLKVKGLGPKTFEQLAGFL 62
comE TIGR01259
comEA protein; This model describes the ComEA protein in bacteria. The com E locus is ...
 72-136 5.45e-20

comEA protein; This model describes the ComEA protein in bacteria. The com E locus is obligatory for bacterial cell competence - the process of internalizing the exogenous added DNA. Lesions in the loci has been variously described for the appearance of competence-related pheonotypes and impairment of competence, suggesting their intimate functional role in bacterial transformation. [Cellular processes, DNA transformation]


Pssm-ID: 213597 [Multi-domain]  Cd Length: 120  Bit Score: 79.18  E-value: 5.45e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 691029546   72 STGQIHLNQANVNEFQQLKGIGEKKAQAIVEYRQKNGSFKNIDEIKNVKGIGPAIFEKNKSRLAL 136
Cdd:TIGR01259  56 KLAAVNINAASLEELQALPGIGPAKAKAIIEYREENGAFKSVDDLTKVSGIGEKSLEKLKDYATV 120
TIGR00426 TIGR00426
competence protein ComEA helix-hairpin-helix repeat region; Members of the subfamily ...
 76-136 1.98e-15

competence protein ComEA helix-hairpin-helix repeat region; Members of the subfamily recognized by this model include competence protein ComEA and closely related proteins from a number of species that exhibit competence for transformation by exongenous DNA, including Streptococcus pneumoniae, Bacillus subtilis, Neisseria meningitidis, and Haemophilus influenzae. This model represents a region of two tandem copies of a helix-hairpin-helix domain (pfam00633), each about 30 residues in length. Limited sequence similarity can be found among some members of this family N-terminal to the region covered by this model. [Cellular processes, DNA transformation]


Pssm-ID: 129520 [Multi-domain]  Cd Length: 69  Bit Score: 66.11  E-value: 1.98e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 691029546   76 IHLNQANVNEFQQ-LKGIGEKKAQAIVEYRQKNGSFKNIDEIKNVKGIGPAIFEKNKSRLAL 136
Cdd:TIGR00426   8 VNINTATAEELQRaMNGVGLKKAEAIVSYREEYGPFKTVEDLKQVPGIGNSLVEKNLAVITL 69
Tex COG2183
Transcriptional accessory protein Tex/SPT6 [Transcription];
91-128 3.36e-10

Transcriptional accessory protein Tex/SPT6 [Transcription];


Pssm-ID: 441786 [Multi-domain]  Cd Length: 719  Bit Score: 56.57  E-value: 3.36e-10
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 691029546  91 GIGEKKAQAIVEYRQKNGSFKNIDEIKNVKGIGPAIFE 128
Cdd:COG2183  502 GLNPTLAKNIVAYRDENGAFKSRKELLKVPRLGPKAFE 539
psbU PRK02515
photosystem II complex extrinsic protein PsbU;
13-131 9.16e-06

photosystem II complex extrinsic protein PsbU;


Pssm-ID: 235048 [Multi-domain]  Cd Length: 132  Bit Score: 42.36  E-value: 9.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691029546  13 FVLIILCLG--VISPSVYAQsfdqNFQEWKAKQQIYDQKLNitksshsngskisqtknfnDSTGQIHLNQANVNEFQQLK 90
Cdd:PRK02515  11 FSLLLGLLGwlGTPQSAQAA----ELPLLAVPQNVADAKLG-------------------EFGEKIDLNNSSVRAFRQFP 67

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 691029546  91 GIGEKKAQAIVeyrqKNGSFKNIDEIKNVKGIG---PAIFEKNK 131
Cdd:PRK02515  68 GMYPTLAGKIV----KNAPYDSVEDVLNLPGLSerqKELLEANL 107
HHH pfam00633
Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated ...
 78-103 8.04e-05

Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated in the central domain of RuvA. The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain.


Pssm-ID: 425789 [Multi-domain]  Cd Length: 30  Bit Score: 37.40  E-value: 8.04e-05
                          10        20
                  ....*....|....*....|....*.
gi 691029546   78 LNQANVNEFQQLKGIGEKKAQAIVEY 103
Cdd:pfam00633   5 LIPASVEELLALPGVGPKTAEAILSY 30
DnaE COG0587
DNA polymerase III, alpha subunit [Replication, recombination and repair];
86-115 4.45e-04

DNA polymerase III, alpha subunit [Replication, recombination and repair];


Pssm-ID: 440352 [Multi-domain]  Cd Length: 1050  Bit Score: 38.90  E-value: 4.45e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 691029546   86 FQQLKGIGEKKAQAIVEYRQKNGSFKNIDE 115
Cdd:COG0587   817 LGAIKGVGEAAAEAIVAAREENGPFTSLFD 846
uvrC PRK00558
excinuclease ABC subunit UvrC;
88-129 1.02e-03

excinuclease ABC subunit UvrC;


Pssm-ID: 234792 [Multi-domain]  Cd Length: 598  Bit Score: 37.79  E-value: 1.02e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 691029546  88 QLKGIGEKKAQAIVEYRqknGSFKNI-----DEIKNVKGIGPAIFEK 129
Cdd:PRK00558 547 DIPGIGPKRRKALLKHF---GSLKAIkeasvEELAKVPGISKKLAEA 590
HHH_2 pfam12826
Helix-hairpin-helix motif; The HhH domain of DisA, a bacterial checkpoint control protein, is ...
 77-103 9.21e-03

Helix-hairpin-helix motif; The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain.


Pssm-ID: 432812 [Multi-domain]  Cd Length: 64  Bit Score: 32.88  E-value: 9.21e-03
                          10        20
                  ....*....|....*....|....*..
gi 691029546   77 HLNQANVNEFQQLKGIGEKKAQAIVEY 103
Cdd:pfam12826  28 ALAEASLEELLEVDDIGPEIAQSIVEF 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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