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Conserved domains on  [gi|691139857|ref|WP_032053253|]
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MULTISPECIES: fumarylacetoacetate hydrolase family protein [Acinetobacter]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FAA_hydro_N_2 pfam18288
Fumarylacetoacetase N-terminal domain 2; This is domain is found in the N-terminal region of ...
 1-78 6.51e-40

Fumarylacetoacetase N-terminal domain 2; This is domain is found in the N-terminal region of Fumarylacetoacetate (FAA) hydrolase (pfam01557). Family members of this domain include Pseudogulbenkiania ferrooxidans and Cupriavidus gilardii.


:

Pssm-ID: 436386  Cd Length: 78  Bit Score: 135.08  E-value: 6.51e-40
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 691139857    1 MKLATLKDGSRDGRLVIVSKDLKTATLATGIALTLQDALENWDEAEPKLQQKYAALNDATEQDAFAFDPAQAMAPLPR 78
Cdd:pfam18288   1 MKLATLKNGTRDGQLVVVSRDLTRAVPAPAIAPTLQAALENWSAVEPALQELYTALNAGTAKDGFPFDPAKCMAPLPR 78
FAA_hydrolase pfam01557
Fumarylacetoacetate (FAA) hydrolase family; This family consists of fumarylacetoacetate (FAA) ...
 82-322 1.58e-33

Fumarylacetoacetate (FAA) hydrolase family; This family consists of fumarylacetoacetate (FAA) hydrolase, or fumarylacetoacetate hydrolase (FAH) and it also includes HHDD isomerase/OPET decarboxylase from E. coli strain W. FAA is the last enzyme in the tyrosine catabolic pathway, it hydrolyses fumarylacetoacetate into fumarate and acetoacetate which then join the citric acid cycle. Mutations in FAA cause type I tyrosinemia in humans this is an inherited disorder mainly affecting the liver leading to liver cirrhosis, hepatocellular carcinoma, renal tubular damages and neurologic crises amongst other symptoms. The enzymatic defect causes the toxic accumulation of phenylalanine/tyrosine catabolites. The E. coli W enzyme HHDD isomerase/OPET decarboxylase contains two copies of this domain and functions in fourth and fifth steps of the homoprotocatechuate pathway; here it decarboxylates OPET to HHDD and isomerizes this to OHED. The final products of this pathway are pyruvic acid and succinic semialdehyde. This family also includes various hydratases and 4-oxalocrotonate decarboxylases which are involved in the bacterial meta-cleavage pathways for degradation of aromatic compounds. 2-hydroxypentadienoic acid hydratase encoded by mhpD in E. coli is involved in the phenylpropionic acid pathway of E. coli and catalyzes the conversion of 2-hydroxy pentadienoate to 4-hydroxy-2-keto-pentanoate and uses a Mn2+ co-factor. OHED hydratase encoded by hpcG in E. coli is involved in the homoprotocatechuic acid (HPC) catabolism. XylI in P. putida is a 4-Oxalocrotonate decarboxylase.


:

Pssm-ID: 460252  Cd Length: 210  Bit Score: 122.78  E-value: 1.58e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691139857   82 WADASAFLNHgsLMEQAFKLDIKKDKGVPIIYQGAGDDFLGACDDYPVPGEEHQIDFEGEVAVILDDVPMGVQAEQAEKH 161
Cdd:pfam01557   1 VCVGLNYAEH--AREAGKAEPVPDFPIPLVLFVKPPSSLIGPGDPIVRPAGVTKLDYEAELAVVIGRPARDVSPEEALDY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691139857  162 IKLFMLLNDVSLRAHLFKEVSIgfGPLRAK---PSTVFAPVAVTPDELGDaWHDGRIKLPLevqcNGEWFGHPNGEEMSF 238
Cdd:pfam01557  79 IFGYTLANDVSARDLQRREMPL--QWFRGKsfdGFTPLGPWIVTRDELPD-PGDLRLRLRV----NGEVRQDGNTSDMIF 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691139857  239 SFPELVMHLARTRNLKVGTILGSGTFSNQNYkevgsaclaekraieiielGEPKTPFLKFGDRLQFEMKGqdgqsiFGKI 318
Cdd:pfam01557 152 SPAELIAHLSQFMTLRPGDIILTGTPSGVGA-------------------GRAPPVFLKPGDTVEVEIEG------LGTL 206


                  ....
gi 691139857  319 NHQF 322
Cdd:pfam01557 207 RNTV 210
 
Name Accession Description Interval E-value
FAA_hydro_N_2 pfam18288
Fumarylacetoacetase N-terminal domain 2; This is domain is found in the N-terminal region of ...
 1-78 6.51e-40

Fumarylacetoacetase N-terminal domain 2; This is domain is found in the N-terminal region of Fumarylacetoacetate (FAA) hydrolase (pfam01557). Family members of this domain include Pseudogulbenkiania ferrooxidans and Cupriavidus gilardii.


Pssm-ID: 436386  Cd Length: 78  Bit Score: 135.08  E-value: 6.51e-40
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 691139857    1 MKLATLKDGSRDGRLVIVSKDLKTATLATGIALTLQDALENWDEAEPKLQQKYAALNDATEQDAFAFDPAQAMAPLPR 78
Cdd:pfam18288   1 MKLATLKNGTRDGQLVVVSRDLTRAVPAPAIAPTLQAALENWSAVEPALQELYTALNAGTAKDGFPFDPAKCMAPLPR 78
FAA_hydrolase pfam01557
Fumarylacetoacetate (FAA) hydrolase family; This family consists of fumarylacetoacetate (FAA) ...
 82-322 1.58e-33

Fumarylacetoacetate (FAA) hydrolase family; This family consists of fumarylacetoacetate (FAA) hydrolase, or fumarylacetoacetate hydrolase (FAH) and it also includes HHDD isomerase/OPET decarboxylase from E. coli strain W. FAA is the last enzyme in the tyrosine catabolic pathway, it hydrolyses fumarylacetoacetate into fumarate and acetoacetate which then join the citric acid cycle. Mutations in FAA cause type I tyrosinemia in humans this is an inherited disorder mainly affecting the liver leading to liver cirrhosis, hepatocellular carcinoma, renal tubular damages and neurologic crises amongst other symptoms. The enzymatic defect causes the toxic accumulation of phenylalanine/tyrosine catabolites. The E. coli W enzyme HHDD isomerase/OPET decarboxylase contains two copies of this domain and functions in fourth and fifth steps of the homoprotocatechuate pathway; here it decarboxylates OPET to HHDD and isomerizes this to OHED. The final products of this pathway are pyruvic acid and succinic semialdehyde. This family also includes various hydratases and 4-oxalocrotonate decarboxylases which are involved in the bacterial meta-cleavage pathways for degradation of aromatic compounds. 2-hydroxypentadienoic acid hydratase encoded by mhpD in E. coli is involved in the phenylpropionic acid pathway of E. coli and catalyzes the conversion of 2-hydroxy pentadienoate to 4-hydroxy-2-keto-pentanoate and uses a Mn2+ co-factor. OHED hydratase encoded by hpcG in E. coli is involved in the homoprotocatechuic acid (HPC) catabolism. XylI in P. putida is a 4-Oxalocrotonate decarboxylase.


Pssm-ID: 460252  Cd Length: 210  Bit Score: 122.78  E-value: 1.58e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691139857   82 WADASAFLNHgsLMEQAFKLDIKKDKGVPIIYQGAGDDFLGACDDYPVPGEEHQIDFEGEVAVILDDVPMGVQAEQAEKH 161
Cdd:pfam01557   1 VCVGLNYAEH--AREAGKAEPVPDFPIPLVLFVKPPSSLIGPGDPIVRPAGVTKLDYEAELAVVIGRPARDVSPEEALDY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691139857  162 IKLFMLLNDVSLRAHLFKEVSIgfGPLRAK---PSTVFAPVAVTPDELGDaWHDGRIKLPLevqcNGEWFGHPNGEEMSF 238
Cdd:pfam01557  79 IFGYTLANDVSARDLQRREMPL--QWFRGKsfdGFTPLGPWIVTRDELPD-PGDLRLRLRV----NGEVRQDGNTSDMIF 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691139857  239 SFPELVMHLARTRNLKVGTILGSGTFSNQNYkevgsaclaekraieiielGEPKTPFLKFGDRLQFEMKGqdgqsiFGKI 318
Cdd:pfam01557 152 SPAELIAHLSQFMTLRPGDIILTGTPSGVGA-------------------GRAPPVFLKPGDTVEVEIEG------LGTL 206


                  ....
gi 691139857  319 NHQF 322
Cdd:pfam01557 207 RNTV 210
YcgM COG0179
2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) ...
 110-263 2.03e-13

2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 439949  Cd Length: 206  Bit Score: 68.17  E-value: 2.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691139857 110 PIIYQGAGDDFLGACDDYPVPGEEHQIDFEGEVAVILDDVPMGVQAEQAEKHIKLFMLLNDVSLRAHLFKevsiGFGP-L 188
Cdd:COG0179   30 PVLFLKPPSALVGPGDPIPLPAGSGKLDYEGELAVVIGKRARNVSEEDALDHVAGYTVANDVTARDLQRE----RGGQwT 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691139857 189 RAKP---STVFAPVAVTPDELGDaWHDGRIKlpLEVqcngewfghpNGE--------EMSFSFPELVMHLARTRNLKVGT 257
Cdd:COG0179  106 RGKSfdtFCPLGPWIVTADEIPD-PQDLRIR--LRV----------NGEvrqdgntsDMIFSVAELIAYLSQFMTLEPGD 172


                 ....*.
gi 691139857 258 ILGSGT 263
Cdd:COG0179  173 VILTGT 178
 
Name Accession Description Interval E-value
FAA_hydro_N_2 pfam18288
Fumarylacetoacetase N-terminal domain 2; This is domain is found in the N-terminal region of ...
 1-78 6.51e-40

Fumarylacetoacetase N-terminal domain 2; This is domain is found in the N-terminal region of Fumarylacetoacetate (FAA) hydrolase (pfam01557). Family members of this domain include Pseudogulbenkiania ferrooxidans and Cupriavidus gilardii.


Pssm-ID: 436386  Cd Length: 78  Bit Score: 135.08  E-value: 6.51e-40
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 691139857    1 MKLATLKDGSRDGRLVIVSKDLKTATLATGIALTLQDALENWDEAEPKLQQKYAALNDATEQDAFAFDPAQAMAPLPR 78
Cdd:pfam18288   1 MKLATLKNGTRDGQLVVVSRDLTRAVPAPAIAPTLQAALENWSAVEPALQELYTALNAGTAKDGFPFDPAKCMAPLPR 78
FAA_hydrolase pfam01557
Fumarylacetoacetate (FAA) hydrolase family; This family consists of fumarylacetoacetate (FAA) ...
 82-322 1.58e-33

Fumarylacetoacetate (FAA) hydrolase family; This family consists of fumarylacetoacetate (FAA) hydrolase, or fumarylacetoacetate hydrolase (FAH) and it also includes HHDD isomerase/OPET decarboxylase from E. coli strain W. FAA is the last enzyme in the tyrosine catabolic pathway, it hydrolyses fumarylacetoacetate into fumarate and acetoacetate which then join the citric acid cycle. Mutations in FAA cause type I tyrosinemia in humans this is an inherited disorder mainly affecting the liver leading to liver cirrhosis, hepatocellular carcinoma, renal tubular damages and neurologic crises amongst other symptoms. The enzymatic defect causes the toxic accumulation of phenylalanine/tyrosine catabolites. The E. coli W enzyme HHDD isomerase/OPET decarboxylase contains two copies of this domain and functions in fourth and fifth steps of the homoprotocatechuate pathway; here it decarboxylates OPET to HHDD and isomerizes this to OHED. The final products of this pathway are pyruvic acid and succinic semialdehyde. This family also includes various hydratases and 4-oxalocrotonate decarboxylases which are involved in the bacterial meta-cleavage pathways for degradation of aromatic compounds. 2-hydroxypentadienoic acid hydratase encoded by mhpD in E. coli is involved in the phenylpropionic acid pathway of E. coli and catalyzes the conversion of 2-hydroxy pentadienoate to 4-hydroxy-2-keto-pentanoate and uses a Mn2+ co-factor. OHED hydratase encoded by hpcG in E. coli is involved in the homoprotocatechuic acid (HPC) catabolism. XylI in P. putida is a 4-Oxalocrotonate decarboxylase.


Pssm-ID: 460252  Cd Length: 210  Bit Score: 122.78  E-value: 1.58e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691139857   82 WADASAFLNHgsLMEQAFKLDIKKDKGVPIIYQGAGDDFLGACDDYPVPGEEHQIDFEGEVAVILDDVPMGVQAEQAEKH 161
Cdd:pfam01557   1 VCVGLNYAEH--AREAGKAEPVPDFPIPLVLFVKPPSSLIGPGDPIVRPAGVTKLDYEAELAVVIGRPARDVSPEEALDY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691139857  162 IKLFMLLNDVSLRAHLFKEVSIgfGPLRAK---PSTVFAPVAVTPDELGDaWHDGRIKLPLevqcNGEWFGHPNGEEMSF 238
Cdd:pfam01557  79 IFGYTLANDVSARDLQRREMPL--QWFRGKsfdGFTPLGPWIVTRDELPD-PGDLRLRLRV----NGEVRQDGNTSDMIF 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691139857  239 SFPELVMHLARTRNLKVGTILGSGTFSNQNYkevgsaclaekraieiielGEPKTPFLKFGDRLQFEMKGqdgqsiFGKI 318
Cdd:pfam01557 152 SPAELIAHLSQFMTLRPGDIILTGTPSGVGA-------------------GRAPPVFLKPGDTVEVEIEG------LGTL 206


                  ....
gi 691139857  319 NHQF 322
Cdd:pfam01557 207 RNTV 210
YcgM COG0179
2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) ...
 110-263 2.03e-13

2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 439949  Cd Length: 206  Bit Score: 68.17  E-value: 2.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691139857 110 PIIYQGAGDDFLGACDDYPVPGEEHQIDFEGEVAVILDDVPMGVQAEQAEKHIKLFMLLNDVSLRAHLFKevsiGFGP-L 188
Cdd:COG0179   30 PVLFLKPPSALVGPGDPIPLPAGSGKLDYEGELAVVIGKRARNVSEEDALDHVAGYTVANDVTARDLQRE----RGGQwT 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691139857 189 RAKP---STVFAPVAVTPDELGDaWHDGRIKlpLEVqcngewfghpNGE--------EMSFSFPELVMHLARTRNLKVGT 257
Cdd:COG0179  106 RGKSfdtFCPLGPWIVTADEIPD-PQDLRIR--LRV----------NGEvrqdgntsDMIFSVAELIAYLSQFMTLEPGD 172


                 ....*.
gi 691139857 258 ILGSGT 263
Cdd:COG0179  173 VILTGT 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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