|
Name |
Accession |
Description |
Interval |
E-value |
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
9-497 |
6.28e-144 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 422.60 E-value: 6.28e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 9 KRWWILLAVVLAFLPIVIDMTVLHVAVPSLTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIFG 88
Cdd:PRK14995 3 RQWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 89 IASVLAAFSQTASMLIAARALLALGGAMIMPCVLGIIRRTFEDSRERAIALGIWGTIGSAGAAIGPLIGGGLLEYFWWGS 168
Cdd:PRK14995 83 LASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 169 VFLINVPIMLVVAPMCYFLLSRKEAITPGHWAFGQALLLIVGLISFVYALKAGLGGKQSLLIVLPLVVLSIGLLTIFVRK 248
Cdd:PRK14995 163 VFLINVPIVLVVMGLTARYVPRQAGRRDQPLNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIRT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 249 QLNSPQPMLDLSLFSRPAILAGIIMAMVAAGALAGVELTLAMELQYVIRLTPLQAGLFMVPIMVAAAIGGPIAGFLSNKF 328
Cdd:PRK14995 243 QLAASRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 329 GLRLVATMSLILAAIALVSLSYSDFHHPGIIVPFILASIGLTLSIGLTASSIAIMGSVPAEKGGAAGSLESTGYELGTGL 408
Cdd:PRK14995 323 GLRLVATGGMALSALSFYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGAGL 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 409 GITLFGVFMAYIFGSHLQVPSDLTAVLAEKARLSIGDTYLVASQLPVEQGTALINAGKIAFSSAHVNLLLTAGIIIGILS 488
Cdd:PRK14995 403 GIAIFGLLLSRSYSASIRLPAGLPAQLIEKASSSIGEAVQLANSLPPTLGQALLDAAKQAFIWSHSVVLSSAGSMLLLLA 482
|
....*....
gi 691553779 489 IVVFFMLAK 497
Cdd:PRK14995 483 VGVWFSLAK 491
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
17-425 |
1.31e-54 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 187.38 E-value: 1.31e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 17 VVLAFLPIVIDMTVLHVAVPSLTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIFGIASVLAAF 96
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 97 SQTASMLIAARALLALGGAMIMPCVLGIIRRTFEDSReRAIALGIWGTIGSAGAAIGPLIGGGLLEYFWWGSVFLINVPI 176
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGER-RGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 177 MLVVAPMCyfllsrkeaitpghwafgqalllivglisfvyalkaglggkqsllivlplvvlsiglltifvrkqlnspqpm 256
Cdd:cd17321 160 GLVALLLA------------------------------------------------------------------------ 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 257 ldlslfsrPAILAGIIMAMVAAGALAGVELTLAMELQYVIRLTPLQAGLFMVPIMVAAAIGGPIAGFLSNKFGLRLVATM 336
Cdd:cd17321 168 --------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVA 239
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 337 SLILAAIALVSLSYSDFHHPGIIVPFILASIGLTLSIGLTASSIAIMGSVPAEKGGAAGSLESTGYELGTGLGITLFGVF 416
Cdd:cd17321 240 GLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGAL 319
|
....*....
gi 691553779 417 MAYIFGSHL 425
Cdd:cd17321 320 LTAGLSANL 328
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
14-412 |
1.10e-36 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 141.36 E-value: 1.10e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 14 LLAVVLAFLPIVIDMTVLHVAVPSLTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIFGIASVL 93
Cdd:TIGR00711 4 TIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 94 AAFSQTASMLIAARALLALGGAMIMPCVLGIIRRTFEDSReRAIALGIWGTIGSAGAAIGPLIGGGLLEYFWWGSVFLIN 173
Cdd:TIGR00711 84 CGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEK-RGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLIN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 174 VPIMLVVAPMCYFLLSRKEAITPGHWAFGQALLLIVGLISFVYAL-KAGLGGKQSLLIVLPLVVLSIGLLTIFVRKQLNS 252
Cdd:TIGR00711 163 VPIGIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLsEGPERGWFDSNEILILSITGLVAIIAFVVWELTD 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 253 PQPMLDLSLFSRPAILAGIIMAMVAAGALAGVELTLAMELQYVIRLTPLQAGLFMVPIMVAAAIGGPIAGFLSNKFGLRL 332
Cdd:TIGR00711 243 DNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRK 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 333 VATMSLILAAIALVSLSYS-DFHHPGIIVPFILASIGLTLSIGLTASSIAIMGSVPAEKGGAAGSLESTGYELGTGLGIT 411
Cdd:TIGR00711 323 LVTIGLILYAVGFYWRAFTfTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTA 402
|
.
gi 691553779 412 L 412
Cdd:TIGR00711 403 L 403
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
17-444 |
2.79e-33 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 130.00 E-value: 2.79e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 17 VVLAFLPIVIDMTVLHVAVPSLTQSLSATSNQVLWIIDIYpLLMAGLLVPM-GTLADRVGNRKILLIGLVIFGIASVLAA 95
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSY-LLALAIMIPLsGWLADRFGTRRLFLTALALFTLGSLLCG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 96 FSQTASMLIAARALLALGGAMIMPCVLGIIRRTFeDSRERAIALGIWGTIGSAGAAIGPLIGGGLLEYFWWGSVFLINVP 175
Cdd:cd17503 80 LAPNLASLIIFRILQGFGGGVLIPLAQTILLRIY-PPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 176 ImlvvapmcyfllsrkeaitpghwafgqalllivGLISFVYAlkaglggkqsllivlplvvlsiglltifvrkqlnspqP 255
Cdd:cd17503 159 I---------------------------------GILALLLA-------------------------------------P 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 256 MLDLSLFSRPAILAGIIMAMVAAGALAGVELTLAMELQYVIRLTPLQAGLFMVPIMVAAAIGGPIAGFLSNKFGLRLVAT 335
Cdd:cd17503 169 LLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLL 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 336 MSLILAAIALVSLSYSDFHHPGIIVPFILASIGLTLSIGLTASSIAIMGSVPAEKGGAAGSLESTGYELGTGLGITLFGV 415
Cdd:cd17503 249 AGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLAT 328
|
410 420
....*....|....*....|....*....
gi 691553779 416 FMAYIFGSHLQVPSDLTAVLAEKARLSIG 444
Cdd:cd17503 329 LLTNRTQFHHSRLSELLAQQVQKQALIIA 357
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
8-290 |
1.75e-26 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 109.13 E-value: 1.75e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 8 PKRWWILLAVVLAFLPIVIDMTVLHVAVPSLTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIF 87
Cdd:COG0477 10 RRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 88 GIASVLAAFSQTASMLIAARALLALGGAMIMPCVLGIIRRTFEDsRERAIALGIWGTIGSAGAAIGPLIGGGLLEYFWWG 167
Cdd:COG0477 90 GLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPA-RERGRALGLWGAAIGLGLALGPLLGGLLVAALGWR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 168 SVFLINVPIMLVVAPMCYFLLSRKEAITPGHWAFGQALLLIVGLISFVYALKAGLGGKQSLLIVLPLVVLSIGLLTIFVR 247
Cdd:COG0477 169 WIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLL 248
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 691553779 248 KQLNSPQPMLDLSLFSRPAILAGIIMAMVAAGALAGVELTLAM 290
Cdd:COG0477 249 ALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLL 291
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
4-408 |
3.43e-26 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 109.29 E-value: 3.43e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 4 TNLDPKRWWILLAVVLAFLPIVIDMTVLHVAVPSLTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIG 83
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 84 LVIFGIASVLAAFSQTASMLIAARALLALGGAMIMPCVLGIIRRTFEDsRERAIALGIWGTIGSAGAAIGPLIGGGLLEY 163
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPP-ERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 164 FWWGSVFLINVPIMLVVAPMCYFLLSRKEAITPGHWAFGQAlllivglisfvyalkaglggkqsllivlplvvlsigllt 243
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLR--------------------------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 244 ifvrkqlnspqpmldlSLFSRPAILAGIIMAMVAAGALAGVELTLAMELQYVIRLTPLQAGLFMVPIMVAAAIGGPIAGF 323
Cdd:COG2814 202 ----------------ELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGR 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 324 LSNKFGLRLVATMSLILAAIALVSLSysdFHHPGIIVPFILASIGLTLSIGLTASSIAIMGSVPAEKGGAAGSLESTGYE 403
Cdd:COG2814 266 LADRFGRRRLLLIGLLLLALGLLLLA---LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFF 342
|
....*
gi 691553779 404 LGTGL 408
Cdd:COG2814 343 LGGPL 347
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
8-419 |
8.67e-21 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 93.78 E-value: 8.67e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 8 PKRWWILLAVVLAFLPIVIDMTVLHVAVPSLTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIF 87
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 88 GIASVLAAFSQTASMLIAARALLALGGAMIMPCVLGIIRRTFeDSRERAIALGIWGTIGSAGAAIGPLIGGGLLEYFWWG 167
Cdd:COG2271 86 GLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWF-PPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 168 SVFLINVPIMLVVAPMcyfllsrkeaitpghwafgqalllivglisfvyalkaglggkqsllivlplvvlsiglltifvr 247
Cdd:COG2271 165 AAFLILGLPGLLLALL---------------------------------------------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 248 kqlnspqpmldlslfsrpAILAGIIMAMVAAGALAGVELTLAMELQYVIRLTPLQAGLFMVPIMVAAAIGGPIAGFLSNK 327
Cdd:COG2271 181 ------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 328 FGLRLVATMSLILAAIALVSLSYSDFHHPGIIVPFILAsIGLTLSIGLTASSIAIMGSVPAEKGGAAGSLESTGYELGTG 407
Cdd:COG2271 243 LGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFL-AGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGA 321
|
410
....*....|..
gi 691553779 408 LGITLFGVFMAY 419
Cdd:COG2271 322 LGPLLVGYLLDA 333
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
17-420 |
5.31e-20 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 91.48 E-value: 5.31e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 17 VVLAFLPIVIDMTVLHVAVPSLTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIFGIASVLAAF 96
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 97 SQTASMLIAARALLALGGAMIMPCVLGIIRRTFEDsRERAIALGIWGTIGSAGAAIGPLIGGGLLEYFWWGSVFLINVPI 176
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPP-EERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 177 MLVVAPMCYFLLSRKEAITPGhwafgqalllivglisfvyalkaglggkqsllivlplvvlsiglltifvRKQLNSPQPM 256
Cdd:cd17325 160 ALLALVLALLLLPEPRPPPNK-------------------------------------------------RAVSAARLRS 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 257 LDLSLFSRPAILAGIIMAMVAAGALAGVELTLAMELQYVIRLTPLQAGLFMVPIMVAAAIGGPIAGFLSNKFGLRLVATM 336
Cdd:cd17325 191 GLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILI 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 337 SLILAAIALVSLSYSDFHhpgIIVPFILASIGLTLSIGLTASSIAIMGSVPAEKGGAAGSLESTGYELGTGLGITLFGVF 416
Cdd:cd17325 271 GLLLSAVALLLLPLATSF---WLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFL 347
|
....
gi 691553779 417 MAYI 420
Cdd:cd17325 348 YDAF 351
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
29-418 |
6.17e-19 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 88.40 E-value: 6.17e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 29 TVLHVAVPSLTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIFGIASVLAAFSQTASMLIAARA 108
Cdd:cd17504 13 TMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 109 LLALGGAMImPCVLGIIRRTFEDSReRAIALGIWGTIGSAGAAIGPLIGGGLLEYFWWGSVFLINVPIMLVVAPMCyfll 188
Cdd:cd17504 93 LQGIGGAVF-PLAFALVREEFPPER-VPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALV---- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 189 srkeaitpghwafgqalllivglisfvyalkaglggkqsllivlplvvlsiglltifvrkqlnspqPMLDLSLFSRPAIL 268
Cdd:cd17504 167 ------------------------------------------------------------------PLIDLRLLRRRNVL 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 269 AGIIMAMVAAGALAGVELTLAMELQ----YVIRLTPLQAGLFMVPIMVAAAIGGPIAGFLSNKFGLRLVATMSLILAAIA 344
Cdd:cd17504 181 LANITALLAGFGMFMVFQLLPQLLQlptpTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVG 260
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 691553779 345 LVSLSYSDFHHPGIIVPFILASIGltLSIGLTASSIAIMGSVPAEKGGAAGSLESTGYELGTGLGITLFGVFMA 418
Cdd:cd17504 261 LLLLALLHSSLWALVVALLLIGIG--LGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILT 332
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
12-424 |
1.14e-18 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 88.64 E-value: 1.14e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 12 WILLAVVLAFLPIVIDMTVLHVAVPSLTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIFGIAS 91
Cdd:PRK10504 10 WQLWIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 92 VLAAFSQTASMLIAARALLALGGAMIMP----CVLGIIrrtfedSRERAIALGIWGTI-GSAGAAIGPLIGGGLLEYFWW 166
Cdd:PRK10504 90 LFCALSGTLNELLLARVLQGVGGAMMVPvgrlTVMKIV------PREQYMAAMTFVTLpGQVGPLLGPALGGLLVEYASW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 167 GSVFLINVPIMLVVApMCYFLLSRKEAITPGHWAFGQALLLIVGLISFVYALKAGLGGKQSLLIVLPLVVLSIGLLTIFV 246
Cdd:PRK10504 164 HWIFLINIPVGIIGA-IATLMLMPNYTMQTRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVALLLYL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 247 RKQLNSPQPMLDLSLFSRPAILAGIIMAMVAAGALAGVELTLAMELQYVIRLTPLQAGLFMVPIMVAAAIGGPIAGFLSN 326
Cdd:PRK10504 243 LHARNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVN 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 327 KFGLRLVATMSLILaaIALVSLSYSDFHHPG--IIVPFILASIGLTLSIGLTASSIAIMGSVPAEKGGAAGSLESTGYEL 404
Cdd:PRK10504 323 RFGYRRVLVATTLG--LALVSLLFMLVALLGwyYLLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQL 400
|
410 420
....*....|....*....|
gi 691553779 405 GTGLGITLFGVFMAyIFGSH 424
Cdd:PRK10504 401 SMSIGVTIAGLLLG-LFGQQ 419
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
8-418 |
1.16e-18 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 87.63 E-value: 1.16e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 8 PKRWWILLAVVLAFLPIVIDMTVLHVAVPSLTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIF 87
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 88 GIASVLAAFSQTASMLIAARALLALGGAMIMPCVLGIIRRTFEDSReRAIALGIWGTIGSAGAAIGPLIGGGLLEYFWWG 167
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDR-RGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 168 SVFLINVPIMLVVAPMCYFLLSRKEAITPGHwafgqalllivglisfvyalkaglggkqsllivlplvvlsiglltifVR 247
Cdd:COG2223 160 NAFLILGILLLVVAVLAWLFLRDPPAGAAAA-----------------------------------------------AK 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 248 KQLNSPqpmldLSLFSRPAILAGIIMAMVAAGALAGVELTLAMELQYVIRLTPLQAGLFMVPIMVAAAIGGPIAGFLSNK 327
Cdd:COG2223 193 ASLRDQ-----LEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDR 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 328 FGLRLVATMSLILAAIALVSLSYSDFHHPGIIVPFILASIGLTLSIGLTASSIAIMgsVPAEKGGAAGSLESTGYELGTG 407
Cdd:COG2223 268 IGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDI--FPTKNAGAVYGLVGAAGGLGGF 345
|
410
....*....|.
gi 691553779 408 LGITLFGVFMA 418
Cdd:COG2223 346 LGPLLFGALLD 356
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
13-416 |
6.19e-17 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 81.84 E-value: 6.19e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 13 ILLAVVLAFLpiviDMTVLHVAVPSLTQSLSATSNqVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIFGIASV 92
Cdd:cd17502 1 LMLALFLAAL----DQTIVATALPTIVAEFGGLSL-VSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 93 LAAFSQTASMLIAARALLALGGAMIMPCVLGIIRRTFEdSRERAIALGIWGTIGSAGAAIGPLIGGGLLEYFWWGSVFLI 172
Cdd:cd17502 76 LCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVP-PRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 173 NVPImlvvapmcyfllsrkeaitpghwafgqalllivglisfvyalkaglggkqsllivlplvvlsIGLLTIFVRkqlns 252
Cdd:cd17502 155 NLPI--------------------------------------------------------------GGLALALLR----- 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 253 pqpmldlslfsrpAILAGIIMAMVAAGALAGVELTLAMELQYVIRLTPLQAGLFMVPIMVAAAIGGPIAGFLSNKFG-LR 331
Cdd:cd17502 168 -------------TILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGrYK 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 332 LVATMSLILAAIALVSLSYSDFHHPGIIVPFILASIGLTLSIGLTASSIAIMGSVPAEKGGAAGSLESTGYELGTGLGIT 411
Cdd:cd17502 235 PLIVIGTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVA 314
|
....*
gi 691553779 412 LFGVF 416
Cdd:cd17502 315 ITDVF 319
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
33-409 |
1.36e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 80.93 E-value: 1.36e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 33 VAVPSLTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIFGIASVLAAFSQTASMLIAARALLAL 112
Cdd:pfam07690 18 ALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 113 GGAMIMPCVLGIIRRTFEDSrERAIALGIWGTIGSAGAAIGPLIGGGLLEYFWWGSVFLINVPIMLVVAPMCYFLLSRKE 192
Cdd:pfam07690 98 GAGALFPAALALIADWFPPE-ERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 193 AITPGHWAFGQALLlivglisfvyalkaglggkqsllivlplvvlsiglltifvrkqlnspqpMLDLSLFSRPAILAGII 272
Cdd:pfam07690 177 SKRPKPAEEARLSL-------------------------------------------------IVAWKALLRDPVLWLLL 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 273 MAMVAAGALAGVeLTLAMELQYVIRLTPLQAGLFMVPIMVAAAIGGPIAGFLSNKFGLRLVATMSLILAAIALVSLSYSD 352
Cdd:pfam07690 208 ALLLFGFAFFGL-LTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLS 286
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 691553779 353 FHHPGIIVPFILASIGLTLSIGLTASSIAIMGSVPAEKGGAAGSLESTGYELGTGLG 409
Cdd:pfam07690 287 LTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
13-416 |
3.07e-15 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 77.23 E-value: 3.07e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 13 ILLAVVLAFLPIVIDMTVlhVAVPSLTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIFGIASV 92
Cdd:cd17320 2 LLLALLVALGPLAIDMYL--PALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 93 LAAFSQTASMLIAARALLALGGAMIMPCVLGIIRRTFEDsRERAIALGIWGTIGSAGAAIGPLIGGGLLEYFWWGSVFLI 172
Cdd:cd17320 80 LCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSG-AELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 173 nvpimlvvapmcyfllsrkeaitpghwafgQALLLIVGLISFVYALKAglggkqsllivlplvvlsigllTIFVRKQLNS 252
Cdd:cd17320 159 ------------------------------LALLGLLLLLLVLLFLPE----------------------TLPEEKRKPL 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 253 PQPMLD--LSLFSRPAILAGIIMAMVAAGALAGVELTLAMELQYVIRLTPLQAGLFMVPIMVAAAIGGPIAGFLSNKFGL 330
Cdd:cd17320 187 LSSLLRayKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGP 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 331 RLVATMSLILAAIALVSLSYSDFHHPGIIVPFILASIGLTLSIGLTASSIAIMGSVPAEK-GGAAGSLESTGYELGTGLG 409
Cdd:cd17320 267 RRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHvAGTASALLGFLQFLIGALA 346
|
....*..
gi 691553779 410 ITLFGVF 416
Cdd:cd17320 347 GALVGLL 353
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
33-191 |
3.59e-15 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 76.92 E-value: 3.59e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 33 VAVPSLTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIFGIASVLAAFSQTASMLIAARALLAL 112
Cdd:cd17476 19 VILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGL 98
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 691553779 113 GGAMIMPCVLGIIRRTFEDSRERAIALGIWGTIGSAGAAIGPLIGGGLLEYFWWGSVFLINVPIMLVVAPMCYFLLSRK 191
Cdd:cd17476 99 GPAFLLPNAMALLGRTYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVAAIFWTSPS 177
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
11-424 |
5.28e-12 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 67.21 E-value: 5.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 11 WWILLAVVLAFLPIvidmTVLHVAVPSLTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIFGIA 90
Cdd:cd17474 2 YAVFFATLLAVLGV----SIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 91 SVLAAFSQTASMLIAARALLALGGAMIMPCVLGIIRRTFEdSRERAIALGIWGTIGSAGAAIGPLIgGGLLEYFWWGSVF 170
Cdd:cd17474 78 GLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFE-GGERAKAMGLYEAALGLGIAVGPLL-GGLLAAISWRYPF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 171 linvpimlvvapmcyfllsrkeaitpghwaFGQALLLIVGLISFVYALKAGLGGKQSLLIVLPLVVLSIglltifvrkql 250
Cdd:cd17474 156 ------------------------------FLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKA----------- 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 251 nspqpmldlslFSRPAILAGIIMAMVAAGALAGVELTLAMELQYVIRLTPLQAGLFMVPIMVAAAIGGPIAG-FLSNKFG 329
Cdd:cd17474 195 -----------LRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGrLLKKRFG 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 330 LRLVATMSLILAAIALVSLSYSdfHHPGIIVPFILASiGLTLSIGLTASSIAIMGSVPAEKGGAAGSLESTGYELGTGLG 409
Cdd:cd17474 264 ARRILVIGLLLYALSLLLLGFV--PSLALLLIAIVLF-GLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVG 340
|
410
....*....|....*
gi 691553779 410 ITLFGvFMAYIFGSH 424
Cdd:cd17474 341 PLLFG-LLLEIFGLS 354
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
36-418 |
1.39e-10 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 62.95 E-value: 1.39e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 36 PSLTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIFGIASVLAAFSQTASMLIAARALLALGGA 115
Cdd:cd17324 23 PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 116 MIMPCVLGIIRRTFEDSReRAIALGIWGTIGSAGAAIGPLIGGGLLEYFWWGSVFLINVPIMLVVAPMCYFLLSRKEAIT 195
Cdd:cd17324 103 GFWAIAAAYAADLVPPEK-RGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 196 PGHWAFGQALLLivglisfvyalkaglggkqsllivlplvvlsiglltifvrkqlnspqpmldlsLFSRPAILAGIIMAM 275
Cdd:cd17324 182 PGSLGLLSSLLL-----------------------------------------------------LLRNPRLRLAYLITF 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 276 VAAGALAGVELTLAMELQYVIRLTPLQAGLFMVPIMVAAAIGGPIAGFLSNKFGLRLVATMSLILAAIALVsLSYSDFHH 355
Cdd:cd17324 209 LLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLL-LTLLGPSP 287
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 691553779 356 PGIIVPFILasIGLTLSIGLTASSIAIMGSVPAEKgGAAGSLESTGYELGTGLGITLFGVFMA 418
Cdd:cd17324 288 LLLLVGLVL--WGLGFFAAHSALQTRVLRLAPEAR-GLASSLYLAAYNLGGALGAALGGLVLD 347
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
10-189 |
1.40e-10 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 62.68 E-value: 1.40e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 10 RWWILLAVVLAFLPIVIDMTVLHVAVPSLTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIFGI 89
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 90 ASVLAAFSQTASMLIAARALLALGGAMIMPCVLGIIRRTFEDSrERAIALGIWGTIGSAGAAIGPLIGGGLLEYFWWGSV 169
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKK-ERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAA 159
|
170 180
....*....|....*....|
gi 691553779 170 FLINVPIMLVVAPMCYFLLS 189
Cdd:cd17312 160 FLVPGIVGLVVAIILFFFLR 179
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
10-190 |
1.79e-09 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 59.51 E-value: 1.79e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 10 RWWILLAVVLAFLPIVIDMTVLHVAVPSLTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIFGI 89
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 90 ASVLAAFSQTASMLIAARALLALGGAMIMPCVLGIIRRTFeDSRERAIALGIWGTIGSAGAAIGPLIGGGLLEYFWWGSV 169
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWF-PARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWA 159
|
170 180
....*....|....*....|.
gi 691553779 170 FLINVPIMLVVAPMCYFLLSR 190
Cdd:cd17319 160 FIIEGLLGLLLAVLWWFYLRQ 180
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
17-425 |
5.67e-09 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 57.82 E-value: 5.67e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 17 VVLAFLPIVIDMTVLHVAVPSLTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIFGIASVLAAF 96
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 97 SQTASMLIAARALLALGGAMIMPCVLGIIRRTFEDsRERAIALGIWGTIGSAGAAIGPLIGGGLLEYFWWGSVFLINVPi 176
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPE-RERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIA- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 177 mlvvapmcyfllsrkeaitpghwafgqALLLIVGLISFVYALKAGLGGKQSLLIVLPLVVLSIGLLtifvrkqlnspqpm 256
Cdd:cd06174 159 ---------------------------AALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLK-------------- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 257 ldlSLFSRPAILAGIIMAMVAAGALAGVELTLAMELQYVIRLTPLQAGLFMVPIMVAAAIGGPIAGFLSNK-FGLRLVAT 335
Cdd:cd06174 198 ---RVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLL 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 336 MSLILAAIALVSLSYSDFHHPGIIVPFIlasIGLTLSIGLTASSIAIMGSVPAEKGGAAGSLESTGYELGTGLGITLFGV 415
Cdd:cd06174 275 IGLLLMALGLALLLLAPSLLLLLLLLLL---LGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGF 351
|
410
....*....|
gi 691553779 416 FMAYIFGSHL 425
Cdd:cd06174 352 LLAATFGLTG 361
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
68-188 |
7.43e-09 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 54.19 E-value: 7.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 68 GTLADRVGNRKILLIGLVIFGIASVLAAFSQTASMLIAARALLALGGAMIMPCVLGIIRRTFEDSrERAIALGIWGTIGS 147
Cdd:TIGR00880 19 GLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPE-ERGVALGLMSAGIA 97
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 691553779 148 AGAAIGPLIGGGLLEYFWWGSVFLINVPIMLVVAPMCYFLL 188
Cdd:TIGR00880 98 LGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLL 138
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
38-188 |
8.46e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 57.20 E-value: 8.46e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 38 LTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIFGIASVLAAFSQTASMLIAARALLALGGAMI 117
Cdd:cd17325 226 AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLV 305
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 691553779 118 MPCVLGIIRRTFeDSRERAIALGIWGTIGSAGAAIGPLIGGGLLEYFWWGSVFLINVPIMLVVAPMCYFLL 188
Cdd:cd17325 306 FPATLALLADIV-PPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
8-197 |
1.30e-08 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 56.81 E-value: 1.30e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 8 PKRWWILLAVVLAFLPIVIDMTVLHVAVPSLTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIF 87
Cdd:COG2807 14 AGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 88 GIASVLAAFSQTASMLIAARALLALGGAMIMPCVLGIIRRTFedSRERAIALGIWGTIGSAGAAIGPLIGGGLLEYFWWG 167
Cdd:COG2807 94 AAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWF--PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWR 171
|
170 180 190
....*....|....*....|....*....|
gi 691553779 168 SVFLINVPIMLVVAPMCYFLLSRKEAITPG 197
Cdd:COG2807 172 GALAVWALLALLALLLWLPLLRRRPAAAAA 201
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
44-405 |
2.95e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 55.66 E-value: 2.95e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 44 ATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIFGIASVLAAFSQTASMLIAARALLALGGAMIMPCVLG 123
Cdd:cd17473 32 NSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 124 IIRRTFEDSrERAIALGIWGTIGSAGAAIGPLIGGGLLEYFWwgsvflinvpimlvvapmcyfllsrkeaitpgHWAFGQ 203
Cdd:cd17473 112 LIGDYFEGE-ERAKMLGLQSAAMSLGGVVFLLLGGALAEIGW--------------------------------RAPFLV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 204 ALLLIVGLISFVYALKAGLGGKQSLLIVLPLVVLSIGLLTIFVrkqlnspqpmldlslfsrpaILAGIIMAMVaagALAG 283
Cdd:cd17473 159 YLLALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLP--------------------IYFLAFLAML---LFYV 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 284 VELTLAMELQYVIRLTPLQAGLFMVPIMVAAAIGGPIAGFLSNKFGLRLVATMSLILAAIALVSLSYSDfHHPGIIVPFI 363
Cdd:cd17473 216 IPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALAS-GLWVVLLGAI 294
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 691553779 364 LASIGltLSIGLTASSIAIMGSVPAEKGGAAGSLESTGYELG 405
Cdd:cd17473 295 LAGLG--FGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLG 334
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
13-420 |
8.02e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 54.14 E-value: 8.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 13 ILLAVVLAFLPIVIDMTVLhvavPSLTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIFGIASV 92
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVL----PLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 93 LAAFSQTASMLIAARALLALGGAMIMPCVLGIIRRTFEDSReRAIALGIWGTIGSAGAAIGPLIGGGLLEYFWWGSVFLI 172
Cdd:cd17489 77 LYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSR-RGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 173 NVPIMLVVAPMCYFLLSRKEaitpghwafgqalllivglisfvyalkaglggkqsllivlplvvlsiglltifVRKQLNS 252
Cdd:cd17489 156 AAVLALLALLLVFLVKDPPP-----------------------------------------------------VAAEEAE 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 253 PQPMLDLSLFSRPAILAGIIMaMVAAGALAGVELTLAMelqYVIRLTPLQAGLFMVPIMVAAAIGGPIAGFLSNKFGLRL 332
Cdd:cd17489 183 AGTRAFRRLVEKKVLPPALIL-FLASIAYGAISTFLPL---YAAERGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKT 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 333 VATMSLILAAIALVSLSYSDFHHPGIIVPFIlasIGLTLSIGLTASSIAIMGSVPAEKGGAAGSLESTGYELGTGLGITL 412
Cdd:cd17489 259 VIIPGLLLLALGLLLLSFAGSPWMLLLAAVL---YGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLL 335
|
....*...
gi 691553779 413 FGVFMAYI 420
Cdd:cd17489 336 LGLVAELF 343
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
15-414 |
1.16e-07 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 54.17 E-value: 1.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 15 LAVVLAFLPIVIDMTVLHVAVPSLTQSLSATSNqVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIFGIASVLA 94
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPSSN-STWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 95 AFSQTASMLIAARALLALGGAM--IMPCVLG-IIRRTFedsreRAIALGIWGTIGSAGAAIGPLIGGGLLEYFW--WGSV 169
Cdd:cd06179 80 GTAKSVNMLIGGQALIGIGAGTqgLGAAVASeLVPNKY-----RGLVQGVVNLVASPGSALGPLIAGALVEANAagWRWI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 170 FLINV---PIMLVVAPMCYFLLSRKEAITPGHWA------FGQALLLIVGLISFVYALkaGLGGKQ---SLLIVLPLVVL 237
Cdd:cd06179 155 FYINAifnALALILLFFFYHPPPRPQLHGSSTRQklkrldWVGLFLLIAGLVLFLLGL--SWGGNPypwSSAHVIAPLVI 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 238 SIGLLTIF-VRKQLNSPQPMLDLSLFSRPAILAGI-IMAMVAAGALAGVELTLAMELQYVIRLTPLQAGLFMVPIMVAAA 315
Cdd:cd06179 233 GGVLLIAFgLYEWKGTKDGLLPPRLLFRGRNFALIlIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 316 IGGPIAGFLSNKFG---LRLVATMSLILAAIALVSLSYSDFHHPGIIVPFIlasIGLTLSIGLTASSIAIMGSVPAEKGG 392
Cdd:cd06179 313 FGAILAGLLLTKIKhikWQLVAGFVLFTAFLALLALITPDNKALAIAFSVL---AGIGIGGPLVLAIVIVQLSVPPEDIG 389
|
410 420
....*....|....*....|..
gi 691553779 393 AAGSLESTGYELGTGLGITLFG 414
Cdd:cd06179 390 TASGLLGSARALGGAVGTAIFT 411
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
17-183 |
1.50e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 53.36 E-value: 1.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 17 VVLAFLPIVI---DMTVLHVAVPSLTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIFGIASVL 93
Cdd:cd17365 1 LALCFLIIVLdgfDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 94 AAFSQTASMLIAARALLALGGAMIMPCVLGIIRRtFEDSRERAIALGIWGTIGSAGAAIGPLIGGGLLEYFWWGSVFLIN 173
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSE-YAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLG 159
|
170
....*....|
gi 691553779 174 VPIMLVVAPM 183
Cdd:cd17365 160 GVPPLILLPL 169
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
14-377 |
1.81e-07 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 53.13 E-value: 1.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 14 LLAVVLAFLPIVID---MTVLHVAVPSLTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIFGIA 90
Cdd:TIGR00895 16 WRAIILSFLIMLMDgydLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 91 SVLAAFSQTASMLIAARALLALGGAMIMPCVLGIIRRtFEDSRERAIALGIWGTIGSAGAAIGPLIGGGLLEYFWWGSVF 170
Cdd:TIGR00895 96 TLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSE-YAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLF 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 171 LINVPIMLVVAPMCYFLLSRKEAITPGHWAFGQALLLIVGLISFVYALKAGLGGKQSLLivlplvvlsiglltifvrKQL 250
Cdd:TIGR00895 175 YVGGIAPLLLLLLLMRFLPESIDFLVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQ------------------GTK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 251 NSPQPML--DLSLFSRPAILAGIIMAMVAAGALAGVELTLAMELQYvirlTPLQAGLFMVPIMVAAAIGGPIAGFLSNKF 328
Cdd:TIGR00895 237 RSVFKALfqGKTARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGF----SLSLAATGGALFNFGGVIGSIIFGWLADRL 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 691553779 329 GLRlvATMSLILAAIALVSLSYSDFHHPGIIVpFILASIGLTLSIGLTA 377
Cdd:TIGR00895 313 GPR--VTALLLLLGAVFAVLVGSTLFSPTLLL-LLGAIAGFFVNGGQSG 358
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
11-188 |
1.82e-06 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 50.07 E-value: 1.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 11 WWILLAVVLAFLpiviDMTVLHVAVPSLTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIFGIA 90
Cdd:TIGR00710 8 LLLGCLSILGPL----GIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 91 SVLAAFSQTASMLIAARALLALGGAMIMPCVLGIIRRTFEdSRERAIALGIWGTIGSAGAAIGPLIGGGLLEYFWWGSVF 170
Cdd:TIGR00710 84 SLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYP-GEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIF 162
|
170
....*....|....*...
gi 691553779 171 LINVPIMLVVAPMCYFLL 188
Cdd:TIGR00710 163 AFLSLAGILLSALIFFIL 180
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
30-372 |
3.00e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 49.48 E-value: 3.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 30 VLHVAVPSLTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIFGIASVLAAFSQTASMLIAARAL 109
Cdd:cd17478 14 FLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 110 LALGGAMIMPCVLGIIRRTFEDSreRAIALGIWGTIGSAGAAIGPLIGGGLLEYFWWGSVFLINVPIMLVVAPMCYFLLS 189
Cdd:cd17478 94 AGIGSAAFHPEGARLASQAAGGR--RGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 190 RKEAITPghwafgqalllivglisfvyalkaglggkqsllivlplvvlsiglltifvrkqlNSPQPMLDLSLFSRPAILA 269
Cdd:cd17478 172 LKKPEAK------------------------------------------------------KAAAKSSARSTLKGVWRAL 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 270 GIIMAMVAAGALAGVELTLAMELQYVIR-LTPLQAGLFMVPIMVAAAIGGPIAGFLSNKFGLRLVATMSLILAAIALVSL 348
Cdd:cd17478 198 LLLLIIVFLRSWVLSSLTTFLPFYLVQRgYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLF 277
|
330 340
....*....|....*....|....
gi 691553779 349 sysdFHHPGIIVPFILASIGLTLS 372
Cdd:cd17478 278 ----LLTPGIWSYILLVLAGFLLF 297
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
23-188 |
3.14e-06 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 49.25 E-value: 3.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 23 PIVIDMTVlhVAVPSLTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIFGIASVLAAFSQTASM 102
Cdd:PRK10473 16 PAGIDMYL--VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 103 LIAARALLALGGAMIMPCVLGIIRRTFEDSReRAIALGIWGTIGSAGAAIGPLIGGGLLEYFWWGSVFLINVPIMLVVAP 182
Cdd:PRK10473 94 FLAGRFLQGIGAGCCYVVAFAILRDTLDDRR-RAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLL 172
|
....*.
gi 691553779 183 MCYFLL 188
Cdd:PRK10473 173 LSLFIL 178
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
66-197 |
7.90e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 48.14 E-value: 7.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 66 PMGTLADRVGNRKILLIGLVIFGIASVLAAFSQTASMLIAARALLALGGAMIMPCVLGIIRRTFEDSrERAIALGIWGTI 145
Cdd:TIGR00881 49 VMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRS-ERGTWVSFWNCS 127
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 691553779 146 GSAGAAIGPLIGGGLLEYFW-WGSVFLINVPIMLVVAPMCyFLLSRKEAITPG 197
Cdd:TIGR00881 128 HNVGGGLLPPLVLFGIAELYsWHWVFIVPGIIAIIVSLIC-FLLLRDSPQSCG 179
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
70-187 |
1.69e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 47.18 E-value: 1.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 70 LADRVGNRKILLIGLVIFGIASVLAAFSQTASMLIAARALLALGGAMIMPCVLGIIRRTFEdSRERAIALGIWGTIGSAG 149
Cdd:cd17474 258 LKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAP-EEERGTASSLYNFVRFLG 336
|
90 100 110
....*....|....*....|....*....|....*...
gi 691553779 150 AAIGPLIGGGLLEYFWWGSVFLINVPIMLVVAPMCYFL 187
Cdd:cd17474 337 QAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
17-172 |
1.70e-05 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 46.78 E-value: 1.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 17 VVLAFLPIVI---DMTVLHVAVPSLTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIFGIASVL 93
Cdd:cd17380 1 VILLFLATCIcyaDRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 94 AAFSQTASMLIAARALLALGGA--MIMPCVLGIIRRTFEDSrERAIALGIWGTIGSAGAAIGPLIGGGLLEYFWWGSVFL 171
Cdd:cd17380 81 TPLLAYSSLPLLILSRILLGLGegVHFPSMTSLFSRWVPVS-ERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFY 159
|
.
gi 691553779 172 I 172
Cdd:cd17380 160 F 160
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
8-417 |
2.47e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 46.39 E-value: 2.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 8 PKRWWILLAVVLAFLPIVIDMTVLHVAVPSLTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIF 87
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 88 GIASVLAAFSQTASMLIAARALLALGGAMIMPCVLGIIRRTFEDSRERAIALGiwGTIGSAGAAIGPLIGGGLLEyfwwg 167
Cdd:COG0738 84 ALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLL--HAFFSLGALLGPLLGGLLIL----- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 168 svflinvpimlvvapmcyfllsrkeAITPGHWAFGQALLLIVGLISFVYALKAGLGGKQSLLIVLPLVVLSIglltifvr 247
Cdd:COG0738 157 -------------------------LGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASL-------- 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 248 kqlnspqpmldLSLFSRPAILAGIIMAMVAAGALAGVELTLAMELQYVIRLTPLQAGLFMVPIMVAAAIGGPIAGFLSNK 327
Cdd:COG0738 204 -----------KSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKR 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 328 FGLRLVATMSLILAAIALVSLSYSdfhHPGIIVPFILASIGLTLSIGLtASSIAIMGSVPAEKGGAAGSLESTGYELGTG 407
Cdd:COG0738 273 FGPVRLLRLSALLAAVGLLLALLA---PGPWLALIGLALVGLGLSLMF-PTIFSLALDGLGKRTAAAVSAVLIMGIVGGA 348
|
410
....*....|
gi 691553779 408 LGITLFGVFM 417
Cdd:COG0738 349 IGPPLIGFLA 358
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
55-99 |
4.11e-05 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 45.67 E-value: 4.11e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 691553779 55 IYPLLMAGLLVPMGTLADRVGNRKILLIGLVIFGIASVLAAFSQT 99
Cdd:cd17472 40 IYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATS 84
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
260-381 |
5.61e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 45.66 E-value: 5.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 260 SLFSRPAILAGIIMAMVAAGALAGVELTLAMELQYVIRLTPLQAGLFMVPIMVAAAIGGPIAGFLSNKFGLRLVATMSLI 339
Cdd:COG2211 223 ALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLL 302
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 691553779 340 LAAIALVSLSYSDFHHPG-IIVPFILASIGLTLSIGLTASSIA 381
Cdd:COG2211 303 LAALGLLLLFFLGPGNLWlLLVLAALAGIGLGAILVLPWAMLA 345
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
58-181 |
6.95e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 44.88 E-value: 6.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 58 LLMAGLLVPMgtLADRVGNRKILLIGLVIFGIASVLAAFSQTASMLIAARALLALGGAMIMPCVLGIIRRTFEDSrERAI 137
Cdd:cd17330 224 ILAQLLLIPR--LAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSK-EQGK 300
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 691553779 138 ALGIWGTIGSAGAAIGPLIGGGLLEYFWWGSVFLINVPIMLVVA 181
Cdd:cd17330 301 AQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIAL 344
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
67-189 |
8.86e-05 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 44.93 E-value: 8.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 67 MGTLADRVGNRKILLIGLVIFGIASVLAAF--SQTASMLIAARALLALGGAMIM---PCvlGIIRRTFEDSRERAIALGI 141
Cdd:cd17345 58 MGNLSDRSNPKRFLAIGLILSAIINILIGFvpSATSSVGLMFILLFLNGWFQGMgwpPS--GRTMVHWFSKKERGTWTSI 135
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 691553779 142 WGTIGSAGAAI-GPLIGGGLLEYF--WWGSVFLINVPIMLVVAPMCYFLLS 189
Cdd:cd17345 136 WNISHNVGGGLvGPLAGLGLAIFGdgWWRGAFIFPAIIAIIVAVIVLFLGK 186
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
67-188 |
1.26e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 44.18 E-value: 1.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 67 MGTLADRVGNRKILLIGLVIFGIASVLAAFSQTASMLIAARALLALGGAMIMPCVLGIIRRTFEDSRERAIaLGIWGTIG 146
Cdd:cd17391 260 LGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRI-FGYNQSFQ 338
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 691553779 147 SAGAAIGPLIGGGLLEYFWWGSVFLINVPIMLVVAPMCYFLL 188
Cdd:cd17391 339 YLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIFL 380
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
17-188 |
1.32e-04 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 44.10 E-value: 1.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 17 VVLAFLPIVIDM--TVLHVAVPSLTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIFGIASVLA 94
Cdd:cd17323 2 FIISFLTFVVTFgsSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 95 AFSQTASMLIAARALLALGGAMIMPCVLGIIRRTFEdSRERAIALGIWGTIGSAGAAIGPLIGGGLLEYFWWGSVFLINV 174
Cdd:cd17323 82 ALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFT-PEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160
|
170
....*....|....
gi 691553779 175 PIMLVVAPMCYFLL 188
Cdd:cd17323 161 IISGFCLILIFLFL 174
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
238-415 |
1.42e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.07 E-value: 1.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 238 SIGLLTIFVR-----KQLNSPQPMLDLSLFSRPAILAGIIMAMVAAGALAGVELTLAMELQYvirLTPLQAGLFMVPIMV 312
Cdd:cd17370 169 ALLILLFVVKeyprpPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFAFLILRAQELG---LSAALIPLLYALFNL 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 313 AAAIGGPIAGFLSNKFGLRLVATMSLILAAIALVSLSYSDfHHPGIIVPFILASIGLTLSIGLTASSIAIMgsVPAEKGG 392
Cdd:cd17370 246 VYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGS-SLWLLLLGFILWGLYMGAQESIERAAVADL--VPAELRG 322
|
170 180
....*....|....*....|...
gi 691553779 393 AAGSLESTGYELGTGLGITLFGV 415
Cdd:cd17370 323 TAYGLFNTVVGIGWLLASLIAGY 345
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
11-191 |
1.55e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 44.09 E-value: 1.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 11 WWILLAVVLAFLPIVIDMTVLHVAVPSLTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRK--ILLIGLVIFG 88
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 89 IASVLAAFSQTASMLIAARALLALGGAMIMPCVLGIIRRTFeDSRERAIALGIWGTIGSAGAAIGPLIGGGLLEYFWWGS 168
Cdd:COG2271 260 LALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELF-PKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
|
170 180
....*....|....*....|...
gi 691553779 169 VFLInVPIMLVVAPMCYFLLSRK 191
Cdd:COG2271 339 AFLL-LAALALLAALLALLLLRE 360
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
11-164 |
1.85e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 43.74 E-value: 1.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 11 WWILLAVVLAFLPIVIDMTVLhvaVPSLTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIFGIA 90
Cdd:COG2211 231 LLLLLAYLLFFLALALVAALL---LYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 91 SVLAAFSQTASMLIAARALLAL--GGAMIMPCVLGIIRRTFEDS------RERAIALGIWGTIGSAGAAIGPLIGGGLLE 162
Cdd:COG2211 308 LLLLFFLGPGNLWLLLVLAALAgiGLGAILVLPWAMLADVVDYDewktgrRREGLYFGIFTFAIKLGQALAGALAGLLLA 387
|
..
gi 691553779 163 YF 164
Cdd:COG2211 388 LF 389
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
58-416 |
2.69e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 43.41 E-value: 2.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 58 LLMAGLLVPM-GTLADRVGNRKILLIGLVIFGIASVLAAFSQTASMLIAARALLALGGAMIMPCVLGIIRRTFEDSRERA 136
Cdd:cd17355 48 LLAFGLAQPFvGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRG 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 137 IALGIWGTIGSAGAAIGPLIGGGLLEYFWWGSVFLINVPIMLVVAPMCYFLLSRKEAiTPGHWAFGQAlllivGLISFVY 216
Cdd:cd17355 128 LALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPA-DLALRAYDDA-----SPASPGS 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 217 ALKAGLGGKQsllivlplvvlsiglltiFVRkqlnspqpmLDLSLFSRPAILAGIIMAMVAAGALAGveltlamelqyvi 296
Cdd:cd17355 202 TLKEALRSAS------------------FWL---------LALAFFLCGFAVVGLIVHLVPYLADRG------------- 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 297 rLTPLQAGLFMVPIMVAAAIGGPIAGFLSNKFGLRLVATMSLILAAIALVSLSYSDFHHPGIIVPFILASIGLTLSIGLT 376
Cdd:cd17355 242 -ISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLT 320
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 691553779 377 ASSIAIMGsvPAEKGGAAGSLESTGYELGTGLGITLFGVF 416
Cdd:cd17355 321 AALAARYF--GARSYGTLFGLVFAPHQLGSALGPWLGGLL 358
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
68-198 |
1.60e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 40.65 E-value: 1.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 68 GTLADRVGNRKILLIGLVIFGIASVLAAFSQTASMLIAARALLAlggamIMPCVLGIIRRTFEDSRERAI-ALGIWGTIG 146
Cdd:PRK11043 62 GPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQA-----VGVCSAAVIWQALVIDRYPAQkANRVFATIM 136
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 691553779 147 SAGA---AIGPLIGGGLLEYFWWGSVFLINVPIMLVVAPMCYFLLSRKEAITPGH 198
Cdd:PRK11043 137 PLVAlspALAPLLGAWLLNHFGWQAIFATLFAITLLLILPTLRLKPSKKARKQSQ 191
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
35-423 |
2.08e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 40.31 E-value: 2.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 35 VPSLTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIFGIASVLAAFSQTASMLIAARALLALGG 114
Cdd:cd17341 22 GPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSSYWGLLVLGFLLGFA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 115 AMIMPCVLGIIRRTFEDSRERAIALGI--WGTIGSAGAA-IGPLIGGGLLE---YFWWGSVFLINVPIMLVVApmcyfll 188
Cdd:cd17341 102 GANFASGQPWASFWFPKEKIGGAAGGIagAGNMGVAVSQlLAPLIAGAIVFdggFVGWRNAFFVPGILLAIAA------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 189 srkeaitpghwafgqallliVGLISFVYALKAGlggkqsllivlplvvlsiglltifVRKQLNSPQPMLDLSLFSRPAIL 268
Cdd:cd17341 175 --------------------VLVLLFGDDLPTG------------------------KASALEFLKVQLAVLKNYRTWIL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 269 AgiIMAMVAAGALAGVELTLAMELQYVIRLTPLQAGLFMVPIMVAAAIGGPIAGFLSNKFGLRLVATMSLILAAIALVSL 348
Cdd:cd17341 211 S--LLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALL 288
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 691553779 349 SYSDFHHPGIIVPFILASIGltLSIGLTASSIAIMGSVPAEKGGAAGSLesTGYelgTGLGITLFGVFMAYIFGS 423
Cdd:cd17341 289 SLSLPTSGTNLVLFLALFVA--LGLGAGAGNGSVFRMVPFIFRRELGAV--TGL---VGAIGGLGGFFLPLLFGS 356
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
31-420 |
2.25e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 40.28 E-value: 2.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 31 LHVAVPSLT---QSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILL-IGLVIFGIASVLAAFSQTASMLIAA 106
Cdd:cd17490 12 QYVYVPFLSpyaESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIiIGLLFTVLASLIMILFPSPWGLLIA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 107 RALLALGGAM-IMPCVLGIirrTFEDSRERAIALGIWGTIGSAGAAIGPLIGGGLLEYFWWGSVFLinvpimlvvapmcy 185
Cdd:cd17490 92 RFLSGIAAATwVSFTVLYA---SYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFL-------------- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 186 fllsrkeaitpghwafgqaLLLIVGLISFVyalkaglggkqsllivlplvvlsiglLTIFVRKQLNSPQPMLD-----LS 260
Cdd:cd17490 155 -------------------LAALAGVLGFI--------------------------LSLFIKEERREKKPVLTelkelLS 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 261 LFSRPAILAGIIMAMVAAGALAGVELTLAMELQYVIRLTPLQAGLFMVPIMVAAAIGGPIAGFL-SNKFGLRLVATMSLI 339
Cdd:cd17490 190 VLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLfYKKLGERNTIIIGFL 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 340 LAAIALVSLSYsdfhHPGIIVPFIL-ASIGLTLSIGLTASSIAIMGSVPAEKGGAAGSLESTGYelgtGLGITLFGVFMA 418
Cdd:cd17490 270 LLGAYCFLIPF----APNLTLLYLLqALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIY----ALGMFLGPVLVG 341
|
..
gi 691553779 419 YI 420
Cdd:cd17490 342 II 343
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
38-196 |
3.60e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 39.52 E-value: 3.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 38 LTQSLSATSNQVLWIIDIYPLLMAGLLVPMGTLADRVGNRKILLIGLVIFGIASVLAAFSQTASMLIAARALLALGGAMI 117
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 691553779 118 MPCVLGIIRRTFEDSReRAIALGIWGTIGSAGAAIGPLIGGGLLEYFwWGSVFLINVPIMLVVAPMCYFLLSRKEAITP 196
Cdd:cd17329 106 EPASEAMIADVTTPEN-RTRAFSLLYWAINLGVAIGPLLGGLLLLYS-FRLLFLAAAVLFLLAALVLLFLLPETRPKRR 182
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
68-386 |
3.65e-03 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 39.48 E-value: 3.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 68 GTLADRVGNRKILLIGLVIFGIASVLAAFSQTASMLIAARALLALGGAMIMPCVLGIIRRTFEDSRERAIALGIwgTIGS 147
Cdd:cd17384 52 GPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSVAGMGMLASLYPDDKERGKAMGI--ALGG 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 148 --AGAAIGPLIGGGLLEYFWWGSVFLInvpimlvVApmcyfllsrkeaitpghwafgqALLLIVGLISFVYalkaglggk 225
Cdd:cd17384 130 laLGVLVGPPFGGVMYEFVGKSAPFLI-------LA----------------------FLALLDGALQLFI--------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 226 qsllivlplvvlsiglLTIFVRKQLNSPQPMLdLSLFSRPAILAGIIMAMVAAGALAGVELTLAMELQYVIRLTPLQAGL 305
Cdd:cd17384 172 ----------------LQPSVKSEESEEGTPW-KTLLKDPYILIAAGAICFSNSGIAILEPCLPIWMMETMCPPKWQLGT 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 306 FMVPIMVAAAIGGPIAGFLSNKFGLRLVATMSLILAAIALVSLSYSdFHHPGIIVPfilaSIGLTLSIGLTASSI-AIMG 384
Cdd:cd17384 235 AFLPDSIGYLIGTNLFGPLAHKIGRWLCSLLGMLLVGISLILIPLA-KNIYGLIIP----HFGLGLGIGMVDSSMmPLLA 309
|
..
gi 691553779 385 SV 386
Cdd:cd17384 310 YL 311
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
55-188 |
4.24e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.50 E-value: 4.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 55 IYPLLMAGLLVPMGTLADRVGNRKILLIGLVIFGIASVLAAFSQTASMLIAARALLALGGAMIMPCVLGIIRRTFEDSRe 134
Cdd:cd17489 235 VYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHR- 313
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 691553779 135 RAIALGIWGTIGSAGAAIGPLIGGGLLEYFWWGSVFLINVPIMLVVAPMCYFLL 188
Cdd:cd17489 314 RGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
263-420 |
5.98e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 38.80 E-value: 5.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 263 SRPAILAGIIMAMVAAGALAGVELTLAMELQYVIRLTPLQAGLFMVPIMVAAAIGGPIAGFLSNKFGLRLVATMSLILAA 342
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 691553779 343 IALVSLSYSDfhHPGIIVPFILAsIGLTLSIGLTASSIAIMGSVPAEKGGAAGSLESTGYELGTGLGITLFGVFMAYI 420
Cdd:COG2814 87 LGSLLCALAP--SLWLLLAARFL-QGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
68-420 |
7.42e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 38.75 E-value: 7.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 68 GTLADRVGNRKILLIGLVIFGIASVLAAFSQTASMLIAARALLALGGAMIMPCVLGIIRRTF------EDSRERAIALGi 141
Cdd:cd06173 55 GVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALlpelvpKEQLVRANALN- 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 142 wGTIGSAGAAIGPLIGGGLLEYFWWGSVFLINVpIMLVVAPMCYFLLSRKEAITPGHWAFGQALLLIVGLISFVyalkag 221
Cdd:cd06173 134 -SLATQLARIIGPALGGLLVALLGPGGAFAINA-LSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLR------ 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 222 lggkqsllivlplvvlsiglltifvrkqlnspqpmldlslfSRPAILAGIIMAMVAAGALAGVELTLAMELQYVIRLTPL 301
Cdd:cd06173 206 -----------------------------------------RSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 302 QAGLFMVPIMVAAAIGGPIAGFLSNKFGLRLVATMSLILAAIALVSLSYSdfhHPGIIVPFILASIGLTLSIGLTASSIA 381
Cdd:cd06173 245 GYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLS---PSLWLLLAALFLLGLAGGLFNVPLNTL 321
|
330 340 350
....*....|....*....|....*....|....*....
gi 691553779 382 IMGSVPAEKGGAAGSLESTGYELGTGLGITLFGVFMAYI 420
Cdd:cd06173 322 LQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL 360
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
312-423 |
8.34e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 38.78 E-value: 8.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691553779 312 VAAAIGGPIAGFLSNKFGLRLVATMSLILAAIA--LVSLSYSDFHHPGIIVPFILASIGLTLSIGLTAssIAIMGSVPAE 389
Cdd:cd17357 60 IGGAIGSFISAFLANRFGRKNGLLISNALLVVSslLMFLSKSAKSPELLIFGRFLVGIACGLSTGFVP--MYLQEISPSE 137
|
90 100 110
....*....|....*....|....*....|....
gi 691553779 390 KGGAAGSLESTGYELGTGLGiTLFGvfMAYIFGS 423
Cdd:cd17357 138 LRGALGSLTQIGVTLGILLG-QVFG--LPSVLGT 168
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