|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
1-438 |
0e+00 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 859.04 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 1 MDSTLISARRNEETPSLNRARRAALGSFAGAVVDWYDFLLYGITAALVFNREFFPQISPAMGTLAAFATFGVGFLFRPLG 80
Cdd:PRK09952 1 MDSTLISTRPDEGTLSLSRARRAALGSFAGAVVDWYDFLLYGITAALVFNREFFPQVSPAMGTLAAFATFGVGFLFRPLG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 81 GIIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFASIGWWAPVLLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKA 160
Cdd:PRK09952 81 GVVFGHFGDRLGRKRMLMLTVWMMGIATALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 161 FYSSGVQVGYGVGLLLSTGLVSLISQLTTDEQFLSWGWRIPFIFSIVLVVVALWIRNGMEESAEFERQQREKPVAKKRLP 240
Cdd:PRK09952 161 FYSSGVQVGYGVGLLLSTGLVSLISMMTTDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFEQQQHEQAAAKKRIP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 241 VMEALVQHPGAFLKIIALRLCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLVVGGISCLTIPCFAWLADRFGRRRVYI 320
Cdd:PRK09952 241 VIEALLRHPGAFLKIIALRLCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 321 TGALIGTLSAWPFFMALEAQSVFWIVFFAIMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVGYQVASVVGGGFTPFIA 400
Cdd:PRK09952 321 TGALIGTLSAFPFFMALEAQSIFWIVFFSIMLANIAHDMVVCVQQPMFTEMFGASYRYSGAGVGYQVASVVGGGFTPFIA 400
|
410 420 430
....*....|....*....|....*....|....*...
gi 692191013 401 AALVTFSGGNWHSVAIYLLAGCLLSAATALLMKETTHS 438
Cdd:PRK09952 401 AALVTYFGGSWHSVAIYLLAGCLISAMTALLMKDNQRA 438
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
21-431 |
0e+00 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 517.85 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 21 RRAALGSFAGAVVDWYDFLLYGITAALVFNREFFPQISPAMGTLAAFATFGVGFLFRPLGGIIFGHFGDRLGRKRMLMLT 100
Cdd:cd17369 1 RRVALASLVGTAIEWYDFFIYGTAAALVFNKLFFPAVDPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 101 VWMMGIATALIGILPSFASIGWWAPVLLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGL 180
Cdd:cd17369 81 LLLMGIATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 181 VSLISQLTTDEQFLSWGWRIPFIFSIVLVVVALWIRNGMEESAEFERQQREKpvAKKRLPVMEALVQHPGAFLKIIALRL 260
Cdd:cd17369 161 FLLLSALLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKEAG--QVVRAPLVEVLRRHWRALLLAIGLRL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 261 CELLTMYIVTAFALNYSTQNLGLPRELFLNIGLVVGGISCLTIPCFAWLADRFGRRRVYITGALIGTLSAWPFFMALEAQ 340
Cdd:cd17369 239 AENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 341 SVFWIVFFAIMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVGYQVASVVGGGFTPFIAAALVTfSGGNWHSVAIYLLA 420
Cdd:cd17369 319 STWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATALVA-ATGSWWPVALYLAA 397
|
410
....*....|.
gi 692191013 421 GCLLSAATALL 431
Cdd:cd17369 398 LAVISLVAALF 408
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
30-425 |
2.15e-166 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 473.30 E-value: 2.15e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 30 GAVVDWYDFLLYGITAALVFNREFFPQISPAMGTLAAFATFGVGFLFRPLGGIIFGHFGDRLGRKRMLMLTVWMMGIATA 109
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHTFFPPSGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 110 LIGILPSFASIGWWAPVLLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISQLTT 189
Cdd:TIGR00883 81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 190 DEQFLSWGWRIPFIFSIVLVVVALWIRNGMEESAEFERQQREKpvAKKRLPVMEALVQHPGAFLKIIALRLCELLTMYIV 269
Cdd:TIGR00883 161 DDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFEKAQEKH--KKKRGPIAETLTKHRKPFLLGLGLVIATTTTFYLI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 270 TAFALNYSTQNLGLPRELFLNIGLVVGGISCLTIPCFAWLADRFGRRRVYITGALIGTLSAWPFFMALEAQSVFWIVFFA 349
Cdd:TIGR00883 239 TTYLPTYLTQTLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAVPLLMALLDSGSFTLFFFL 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 692191013 350 IMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVGYQVASVVGGGFTPFIAAALVTfSGGNWHSVAIYLLAGCLLS 425
Cdd:TIGR00883 319 VLGMALIGGMYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIFGGFAPYIAAALVA-MTGDWYAIGYYLAALALIG 393
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
25-436 |
3.83e-84 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 263.77 E-value: 3.83e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 25 LGSFAGAVVDWYDFLLYGITAaLVFNREFFPQISPAMGTLAAFATFGVGFLFRPLGGIIFGHFGDRLGRKRMLMLTVWMM 104
Cdd:cd17367 2 LGGSVGNLVEWYDWYVYAAFA-LYFAPQFFPSGDPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 105 GIATALIGILPSFASIGWWAPVLLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLI 184
Cdd:cd17367 81 AAGSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 185 SQLTTDEQFLSWGWRIPFIFSIVLVVVALWIRNGMEESAEFErqqREKPVAKKRLPVMEALVQHPGAFLKIIALRLCELL 264
Cdd:cd17367 161 QHTLGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFE---AIAESNEASAGTLRELRRHPRELLLVVGLTAGGTL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 265 TMYIVTAFALNYSTQNLGLPRELFLNIGLVVGGISCLTIPCFAWLADRFGRRRVYITGALIGTLSAWPFFMALEAQSVFW 344
Cdd:cd17367 238 AFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTDSPY 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 345 IVFFAIMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVGYQVASVVGGGFTPFIAAALVTFSGGNWHsvAIYLLAGCLL 424
Cdd:cd17367 318 TAFALVLVGLVFLSGYTSINAVVKAELFPTHVRALGVGLPYALAVAIFGGTAPYVALWLKSIGHEWVF--FWYVAGLIAI 395
|
410
....*....|..
gi 692191013 425 SAATALLMKETT 436
Cdd:cd17367 396 SLVVYLRMPETR 407
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
19-435 |
2.87e-76 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 245.78 E-value: 2.87e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 19 RARRAALGSFAGAVVDWYDFLLYGITAaLVFNREFFPQISPAMGTLAAFATFGVGFLFRPLGGIIFGHFGDRLGRKRMLM 98
Cdd:PRK10642 13 KLRKAITAASLGNAMEWFDFGVYGFVA-YALGKVFFPGADPSVQMIAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 99 LTVWMMGIATALIGILPSFASIGWWAPVLLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLST 178
Cdd:PRK10642 92 ITIVIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 179 GLVSLISQLTTDEQFLSWGWRIPFIFSIVLVVVALWIRNGMEESAEF-------ERQQREKPVAKKRLPVMEALVQHPGA 251
Cdd:PRK10642 172 GVVVLISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFqqhvdklEQGDREGLQDGPKVSFKEIATKHWRS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 252 FLKIIALRLCELLTMYIVTAFALNYSTQNLGLPRE--LFLNIGLVVGGIscLTIPCFAWLADRFGRRRVYITGALIGTLS 329
Cdd:PRK10642 252 LLTCIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDhgVLIIIAIMIGML--FVQPVMGLLSDRFGRRPFVILGSVALFVL 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 330 AWPFFMaLEAQSVFWIVFFAIMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVGYQVaSVVGGGFTPFIAAALVTfSGG 409
Cdd:PRK10642 330 AIPAFI-LINSNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNI-SVLVAGLTPTLAAWLVE-STQ 406
|
410 420
....*....|....*....|....*.
gi 692191013 410 NWHSVAIYLLAGCLLSAATALLMKET 435
Cdd:PRK10642 407 NLMMPAYYLMVVAVIGLITGVTMKET 432
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
30-436 |
2.72e-75 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 239.95 E-value: 2.72e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 30 GAVVDWYDFLLYGITAALVfNREFFPQISPAMGTLAAFATFGVGFLFRPLGGIIFGHFGDRLGRKRMLMLTVWMMGIATA 109
Cdd:cd17366 7 GNAMEWFDFGVYGYLAVTI-GKVFFPGGDPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILMAASTF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 110 LIGILPSFASIGWWAPVLLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISQLTT 189
Cdd:cd17366 86 CIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTLLTLLLT 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 190 DEQFLSWGWRIPFIFSIVLVVVALWIRNgmeesaeferqqrekpvakkrlpvmealvqhpgAFLKIIALRLCELLTMYIV 269
Cdd:cd17366 166 EAQMLDWGWRIPFLIAAPLGLVGLYLRR---------------------------------PLLICIGLVLVFNVTNYML 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 270 TAFALNYSTQNLGLPRELFLNIGLVVGGISCLTIPCFAWLADRFGRRRVYITGALIGTLSAWPFFMALEAQSVfWIVFFA 349
Cdd:cd17366 213 LSYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFLLMNSGSI-AAIFIG 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 350 IMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVGYQVASVVGGGFTPFIAAALVTFSgGNWHSVAIYLLAGCLLSAATA 429
Cdd:cd17366 292 LLVLGLLLSCYTATMASTLPALFPTHVRYSALAIAFNISVSLFGGTTPLVASWLVSAT-GNPLMPAYYLMVAAVVGLVAV 370
|
....*..
gi 692191013 430 LLMKETT 436
Cdd:cd17366 371 LFLTETA 377
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
25-435 |
5.46e-68 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 221.86 E-value: 5.46e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 25 LGSFAGAVVDWYDFLLYGITAALVfNREFFPQISPAMGTLAAFATFGVGFLFRPLGGIIFGHFGDRLGRKRMLMLTVWMM 104
Cdd:cd17368 2 LAATSGNALEFFDFGVYGFFAVYI-GRLFFPSGSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 105 GIATALIGILPSFASIGWWAPVLLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLI 184
Cdd:cd17368 81 ALGTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 185 SQLTTDEQFLSWGWRIPFIFSIVLVVVALWIRNGMEESAEFerqqREKPVAKKRLPVMEALVQHPGAFLKIIALRLCELL 264
Cdd:cd17368 161 SLTLTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAF----LERKARPTRRELFALLANNRRIILLGMLLVAGSTV 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 265 TMYIVTAFALNYSTQNLGLPRELFLNIGLVVGGISCLTIPCFAWLADRFGRRRVYITGALIGTLSAWPFFMALEAQSVFW 344
Cdd:cd17368 237 TFYFTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFAWLTAAPSFG 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 345 IVFFAIMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVGYQVASVVGGGFTPFIAAALVTFsGGNWHSVAIYLLAGCLL 424
Cdd:cd17368 317 RLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIFGGFAQFIVTWLIEL-TGSPLAPAWYLMGAALL 395
|
410
....*....|.
gi 692191013 425 SAATALLMKET 435
Cdd:cd17368 396 GLLATLMLRET 406
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
24-430 |
1.83e-64 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 210.92 E-value: 1.83e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 24 ALGSFAGAVVDWYDFLLYGITAALVFnreffPQISPAMGTLAAFATFGVGFLFRPLGGIIFGHFGDRLGRKRMLMLTVWM 103
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLA-----AEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 104 MGIATALIGILPSfasigwwaPVLLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSL 183
Cdd:cd17316 76 FGLATLLIGLLPT--------PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 184 ISQLTTDEqflsWGWRIPFIFSIVLVVVALWIRNGMeesaeferqqrekpvakkrlpvmealvqhpgafLKIIALRLCEL 263
Cdd:cd17316 148 LIPLLSGD----WGWRILFLIGALPALLALLLRRRT---------------------------------LLLILLWFFIS 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 264 LTMYIVTAFALNYSTQNLGLPRELFLNIGLVVGGISCLTIPCFAWLADRFGRRRVYITGALIGTLSAWPFFMALEAQsvF 343
Cdd:cd17316 191 FGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGS--P 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 344 WIVFFAIMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVGYQVASVVGGGFTPFIAAALVtfSGGNWHSVAIYLLAGCL 423
Cdd:cd17316 269 TLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLA--STGGTGVPALILALLAI 346
|
....*..
gi 692191013 424 LSAATAL 430
Cdd:cd17316 347 VALIVAL 353
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
1-403 |
9.36e-56 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 190.40 E-value: 9.36e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 1 MDSTLISARRNEETPSLNRARRAALGSFAGAVVDWYDFLLYGItAALVFNREFFPQISPAMGTLAAFATFGVGFLFRPLG 80
Cdd:PRK10406 1 MAESTVTADSKLTSSDTRRRIWAIVGASSGNLVEWFDFYVYSF-CSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 81 GIIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFASIGWWAPVLLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKA 160
Cdd:PRK10406 80 GWLFGRIADKHGRKKSMLISVCMMCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 161 FYSSGVQVGYGVGLLLSTGLVSLISQLTTDEQFLSWGWRIPFIFSIVLVVVALWIRNGMEESAEFERQqrekpvAKKRLP 240
Cdd:PRK10406 160 FYASFQYVTLIGGQLLALLVVVVLQQTLEDAELREWGWRIPFALGAVLAVVALWLRRQLDETSQQETR------ALKEAG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 241 VMEALVQHPGAFLKIIALRLCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLVVGGISCLTIPCFAWLADRFGRRRVYI 320
Cdd:PRK10406 234 SLKGLWRNRRAFIMVLGFTAAGSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSML 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 321 TGALIGTLSAWPFFMALEAQSVFWIVFFAIMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVGYQVASVVGGGFTPFIA 400
Cdd:PRK10406 314 CFGSLAALFTVPILSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANALFGGSAEYVA 393
|
...
gi 692191013 401 AAL 403
Cdd:PRK10406 394 LSL 396
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
22-430 |
1.95e-53 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 184.38 E-value: 1.95e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 22 RAALGSFAGAVVDWYDFLLYGITAALVfNREFFPQISPAMGTLAAFATFGVGFLFRPLGGIIFGHFGDRLGRKRMLMLTV 101
Cdd:PRK15075 15 RAILRVTSGNFLEMFDFFLFGFYATAI-AKTFFPAGNEFASLMLTFAVFGAGFLMRPLGAIVLGAYIDRVGRRKGLIVTL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 102 WMMGIATALIGILPSFASIGWWAPVLLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLV 181
Cdd:PRK15075 94 SIMASGTLLIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWQSASQQVAVVFAALLG 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 182 SLISQLTTDEQFLSWGWRIPFIFSIVLVVVALWIRNGMEESAEFErQQREKPVAKKrlpVMEALVQHPGAFLKIIALRLC 261
Cdd:PRK15075 174 YLLNQWLSPAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEETEEFL-ARKHRPSMRE---IFRSLAANWRIVLAGMLMVAM 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 262 ELLTMYIVTAFALNYSTQNLGLPRELFLNIGLVVGGISCLTIPCFAWLADRFGRRRVYITGALIGTLSAWPFFMALEAQS 341
Cdd:PRK15075 250 TTVSFYLITVYTPTFGKTVLHLSAADSLLVTLCVGVSNFIWLPIGGALSDRIGRRPVLIAFTVLAILTAYPALSWLVAAP 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 342 VF--------WIVFFAIMLaNIAhdMVVCVqqpmfTELFGASYRYSGAGVGYQVASVVGGGFTPFIAAALVTFSG----- 408
Cdd:PRK15075 330 SFarmlavelWLSFLYGSY-NGA--MVVAL-----TEVMPAEVRTAGFSLAYSLATAIFGGFTPAISTWLIHVTGdkaap 401
|
410 420
....*....|....*....|..
gi 692191013 409 GNWHSVAiyllAGCLLSAATAL 430
Cdd:PRK15075 402 GYWLSFA----AVCGLIATLVL 419
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
26-435 |
2.80e-30 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 120.87 E-value: 2.80e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 26 GSFAGAVVDWYDFLLYGITAalvfnreffPQISPAMGTLAAFA--TFGVGFLFRPLGGIIFGHFGDRLGRKRMLMLTVWM 103
Cdd:cd17371 3 AAFLGWALDGFDLLLLGLVL---------PALIAEFGLDEAEAglLGTVTLAGGAIGGILGGILADRFGRVRVLVITILL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 104 MGIATALIGILPSFASigwwapvlLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSL 183
Cdd:cd17371 74 FAVFTLLCGFAQNYWQ--------LLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAAL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 184 ISQLTTDEqflsWGWRIPFIFSIVLVVVALWIRNGMEESAEFErQQREKPVAKKRLPVMEALVQHP--GAFLKIIALRLC 261
Cdd:cd17371 146 LFPLLPPE----IAWRVLFLLGALPALLVLFIRRFVKEPPQWQ-AARAARRHFADRPSLRELFSPPllRTTLLASLLATG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 262 ELLTMYIVTAFALNYSTQNLGLPRE--LFLNIGLVVGGIscLTIPCFAWLADRFGRRRVYITGALIGTLS-AWPFFMALE 338
Cdd:cd17371 221 ALGGYYGITTWLPSYLTGERGLSFEgsAGYLVVTILGGF--LGYLAGGFLADRIGRRNNFALFALGSAISiLLYFFLPLS 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 339 AQSVFWIVFFAIMLANIahdmVVCVQQPMFTELFGASYRYSGAGVGYQVASVVGGGFtPFIAAALVTfSGGNWHSVAIYL 418
Cdd:cd17371 299 PTLILILGFPLGFFASG----PFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALF-PFLVGFLAT-SGSLGTAIAVFA 372
|
410
....*....|....*..
gi 692191013 419 LAGCLLSAATALLMKET 435
Cdd:cd17371 373 AVYYIAGLVLALLLPET 389
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
18-434 |
4.08e-27 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 111.90 E-value: 4.08e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 18 NRARRAALGSFAGAVVDWYDFLLYGItaalvfnreFFPQISPAMG-TLAAFAT-FGVGFLFRPLGGIIFGHFGDRLGRKR 95
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSV---------LAPPLAEEFGlSAAQLGLlFAIPVLVGALLRIPLGFLVDRFGPRR 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 96 MLMLTVWMMGIATALIGILPSFAsigwwapvLLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLL 175
Cdd:COG2223 72 VLLIGLLLLGIGLLLLALAVSYW--------LLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAA 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 176 LSTGLVSLIsqlttdeqFLSWGWRIPF-IFSIVLVVVALWIRNGMEESAEFERQqrekpVAKKRLPVMEALVQHPgAFLK 254
Cdd:COG2223 144 VAAFLAPLL--------IAAFGWRNAFlILGILLLVVAVLAWLFLRDPPAGAAA-----AAKASLRDQLEALRDP-RFWL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 255 IIALRLCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLVVGGISCLTIPCFAWLADRFGRRRVYITGALIGTLSAWPFF 334
Cdd:COG2223 210 LSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLA 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 335 MALEAqsvFWIVFFAIMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVGYQVASvVGGGFTPFIAAALVTFSgGNWHSV 414
Cdd:COG2223 290 LALGS---LWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGG-LGGFLGPLLFGALLDAT-GSYTAA 364
|
410 420
....*....|....*....|
gi 692191013 415 AIYLLAGCLLSAATALLMKE 434
Cdd:COG2223 365 FLVFAVLALVALVLTLLLYR 384
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
13-436 |
3.88e-25 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 105.72 E-value: 3.88e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 13 ETPSLNRARRAALGSFAGAVVDWYDFLLYGItAALVFNREFfpQISPAMGTLAafatFGVGFLFRPLGGIIFGHFGDRLG 92
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSV-AAPPLQADL--GLSAAQLGLL----ASAFFLGYALGQIPAGLLADRFG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 93 RKRMLMLTVWMMGIATALIGILPSFASigwwapvlLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGV 172
Cdd:COG2271 74 RRRVLAIGLLLWGLATLLFGFATSFWQ--------LLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 173 GLLLSTGLVSLIsqlttdeqFLSWGWRIPFIFSIVLVVVALWIRngmeesaeferqqrekpvakkrlpvmealvqhpgaF 252
Cdd:COG2271 146 GGALAPPLLGWL--------LAAFGWRAAFLILGLPGLLLALLR-----------------------------------F 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 253 LKIIALRLCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLVVGGISCLTIPCFAWLADRFGRRR--VYITGALIGTLSA 330
Cdd:COG2271 183 WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALAL 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 331 WPFFMAleaqSVFWIVFFAIMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVGYqVASVVGGGFTPFIAAALVTFSGgn 410
Cdd:COG2271 263 LLLALL----PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVN-TFGFLGGALGPLLVGYLLDATG-- 335
|
410 420
....*....|....*....|....*.
gi 692191013 411 WHSVAIYLLAGCLLSAATALLMKETT 436
Cdd:COG2271 336 YQAAFLLLAALALLAALLALLLLRET 361
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
14-392 |
5.73e-24 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 101.97 E-value: 5.73e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 14 TPSLNRARRAALGSFAGAVVDWYDFLLYGITAALVFNREffpQISPAMGTLAAFATFgvgfLFRPLGGIIFGHFGDRLGR 93
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADL---GASPAQAGLVVTAYL----LGAALGAPLAGRLADRFGR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 94 KRMLMLTVWMMGIATALIGILPSFAsigwwapvLLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVG 173
Cdd:COG2814 75 RRVLLLGLLLFALGSLLCALAPSLW--------LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLG 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 174 LLLSTGLVSLISQLttdeqflsWGWRIPFIFSIVLVVVALWIRngmeesaeFERQQREKPVAKKRLPVMEALVQHPGAFL 253
Cdd:COG2814 147 PALGPLLGGLLADL--------FGWRWVFLVNAVLALLALLLL--------LRLLPESRPAARARLRGSLRELLRRPRLL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 254 KIIALRLCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLVVGGISCLTIPCFAWLADRFGRRRVYITGALIGTLSAWPF 333
Cdd:COG2814 211 LLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLL 290
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 692191013 334 FMAleaqSVFWIVFFAIMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVGYQVASVVG 392
Cdd:COG2814 291 ALA----GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
11-326 |
1.96e-23 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 99.50 E-value: 1.96e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 11 NEETPSLNRARRAALGSFAGAVVDWYDFLLYGITAALVfnREFFPQISPAMGTLAAfatfgVGFLFRPLGGIIFGHFGDR 90
Cdd:COG0477 3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSI--AADLGASSAQLGWIVS-----AYLLGRAIGLLLFGRLGDR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 91 LGRKRMLMLTVWMMGIATALIGILPSfasigwwaPVLLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGY 170
Cdd:COG0477 76 YGRKRVLLIGLLLFGLASLLCGLAPS--------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAI 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 171 GVGLLLSTGLVSLISQLttdeqflsWGWRIPFIFSIVLVVVALWIRNGMEESAEFERQQREKPVAKKRLPVMEALVQHPG 250
Cdd:COG0477 148 GLGLALGPLLGGLLVAA--------LGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALL 219
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 692191013 251 AFLKIIALRLCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLVVGGISCLTIPCFAWLADRFGRRRVYITGALIG 326
Cdd:COG0477 220 LLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
23-435 |
6.57e-21 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 94.65 E-value: 6.57e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 23 AALGSFagavVDWYDFLLYG-ITAALVFNREFF------PQISPAMGTLAAFATFGVGflfRPLGGIIFGHFGDRLGRKR 95
Cdd:pfam00083 5 AALGGF----LFGYDTGVIGaFLTLIDFFKNFGlsksvsSLAALSVLSGLIVSIFSVG---CFIGSLFAGKLGDRFGRKK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 96 MLMltvwmMGIATALIGILPSFASIGWWAPVLLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLL 175
Cdd:pfam00083 78 SLL-----IANVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGIL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 176 LSTGLVsLISQLTTDeqflSWGWRIPF----IFSIVLVVVALW---------IRNGMEESAEFERQQREKPVAKKRLPVM 242
Cdd:pfam00083 153 LAYIFG-LGLNKTSN----SDGWRIPLglqlVPALLLIIGLLFlpesprwlvEKGRLEEAREVLAKLRGVPDVDRELDEI 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 243 EALVQHPGAFLKIIALRLCEL------LTMYIVTAFALNYSTQN--LGLPRELFLNIGL--------VVGGISCLTIPCF 306
Cdd:pfam00083 228 KDSLEAGQEAEKASWKELFSTktrrqrLLIGVMLQIFQQLTGINaiFYYSTTIFENLGLsdsflvtiIVGVVNFVFTFIA 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 307 AWLADRFGRRRVYITGALIGTLSAW----PFFMALEAQSVFWIVF-FAIMLANIAHDMVV-CVQQPMFTELFGASYRYSG 380
Cdd:pfam00083 308 IFLVDRFGRRPLLLLGAAGMAICFVilgiVALLGVSKSDWAGIVAiVFIALFIAFFAMGWgPVPWVIVSELFPLSVRSKA 387
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 692191013 381 AGVGYQ---VASVVGGGFTPFIAAALvtfsgGNWHSVAIYLLAGCLLSAATALLMKET 435
Cdd:pfam00083 388 MALATAanwLANFLIGFLFPIITDAI-----GLGYTFFIFAGLLVLFIIFVFFFVPET 440
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
24-432 |
3.42e-19 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 89.19 E-value: 3.42e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 24 ALGSFAGAVVdwydFLLYGITAALVFNREFFpqISPAMGTLAAFATFGVGFLFRPLGGIIFGHFGDRLGRKRMLML-TVW 102
Cdd:COG2211 16 GLGDLGLNLA----FGLLSAYLLYFYTDVLG--LSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWILiGAI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 103 MMGIATALIGILPSFASIG--WWAPVLLVTLRAIQGFAVGGEWggaALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGL 180
Cdd:COG2211 90 PLALSFVLLFTAPDLSPTGklIYALVTYLLLGLAYTLVNIPYS---ALGAELTPDYEERTRLSSWRFAFAGLGGLLASVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 181 VSLISQLTTDEQflSWGWRIPF-IFSIVLVVVALWIRNGMEESAEFERQqrekpvaKKRLPVMEALVQHPGAFLKIIALR 259
Cdd:COG2211 167 PPPLVAAFGGDA--ALGYRLTAlIFAVLGLLAFLLTFFGTKERPVPEEE-------KVSLKESLKALLKNRPFLLLLLAY 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 260 LCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLVVGGISCLTIPCFAWLADRFGRRRVYITGALIGTLSAWPFFMALEA 339
Cdd:COG2211 238 LLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 340 QsvFWIVFFAIMLANIAHDMVVCVQQPMFTELFGASYRYSG---AGV---GYQVASVVGGGFTPFIAAALVTFSGGNWHS 413
Cdd:COG2211 318 N--LWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGrrrEGLyfgIFTFAIKLGQALAGALAGLLLALFGYVAGA 395
|
410 420
....*....|....*....|....*....
gi 692191013 414 V----------AIYLLAGCLLSAATALLM 432
Cdd:COG2211 396 AqspsaltgirLLFFLLPAVLLLLAALLL 424
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
16-403 |
7.54e-18 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 85.52 E-value: 7.54e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 16 SLNRA-RRAALGSFAGAVVDWYDFLLygITAALV-FNREFfpqispAMGTLAAFATFGVGFLFRPLGGIIFGHFGDRLGR 93
Cdd:PRK03893 13 HLNRAqWKAFSAAWLGYLLDGFDFVL--ITLVLTeVQGEF------GLTTVQAASLISAAFISRWFGGLLLGAMGDRYGR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 94 KRMLMLTVWMMGIATALIGILPSFASigwwapvlLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVG 173
Cdd:PRK03893 85 RLAMVISIVLFSVGTLACGFAPGYWT--------LFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 174 LLLSTGLVSLISQLttdeqflsWGWRIPFIFSIVLVVVALWIRNGMEESAEFERQQREKP-------------------- 233
Cdd:PRK03893 157 AVVAAQVYSLVVPV--------WGWRALFFIGILPIIFALWLRKNLPEAEDWKEKHAGKApvrtmvdilyrgehriinil 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 234 ---VAKKRLPVMEALVQHPGAFLKIIAL----------------RLCELLTMYIVTAFALNYS--TQNLgLPRELFLNIG 292
Cdd:PRK03893 229 ltlAAAAALWFCFAGNLQNAAIVAVLGLlcaaifisfmvqssgkRWPTGVMLMVVVLFAFLYSwpIQAL-LPTYLKTDLG 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 293 LVVGGIS-CLTIPCF---------AWLADRFGRRRVYITGALIGTLSAWPFFmALEAQSVFWI---VFFAIMLANIAHDM 359
Cdd:PRK03893 308 YDPHTVAnVLFFSGFgaavgccvgGFLGDWLGTRKAYVCSLLISQLLIIPVF-AIGGANVWVLgllLFFQQMLGQGISGL 386
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 692191013 360 VvcvqqPMF-TELFGASYRYSGAGVGYQVASvVGGGFTPFIAAAL 403
Cdd:PRK03893 387 L-----PKLiGGYFDTEQRAAGLGFTYNVGA-LGGALAPILGALI 425
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
17-408 |
1.05e-17 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 84.59 E-value: 1.05e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 17 LNRARRAALGS-FAGAVVDWYDFLL-----YGITAALvfnreffpQISPAMGTLAAfatfGVGFLFRPLGGIIFGHFGDR 90
Cdd:PRK12307 12 ITRPQKNALFSaWLGYVFDGFDFMLifyimYLIKADL--------GLTDMEGAFLA----TAAFIGRPFGGALFGLLADK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 91 LGRKRMLMLTVWMMGIATALIGILPSFasigwwapVLLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGY 170
Cdd:PRK12307 80 FGRKPLMMWSIVAYSVGTGLSGLASGV--------IMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGF 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 171 GVGLLLSTGLVSLISQlttdeqflSWGWRIPFIFSIVLVVVALWIRNGMEESAEFERQQREKPVAKKRLPVMEALVQHPG 250
Cdd:PRK12307 152 GIGNIIAAYFMPSFAE--------AYGWRAAFFVGLLPVLLVIYIRARAPESKEWEEAKLSGKGKHSQSAWSVFSLSMKG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 251 AFLKI-IALRLCELLTMYIVtaFALNYSTQNLgLPRELFLNiGLVVGGISCLTIPC----------FAWLADRFGRRRVY 319
Cdd:PRK12307 224 LFNRAqFPLTLCVFIVLFSI--FGANWPIFGL-LPTYLAGE-GFDTGVVSNLMTAAafgtvlgnivWGLCADRIGLKKTF 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 320 ITGALIGTLSAWP-FFMALEAQSVFWIVFFAIMLANIAHDMVVcvqqPMFT-ELFGASYRYSGAGVGYQVASvVGGGFTP 397
Cdd:PRK12307 300 SIGLLMSFLFIFPlFRIPQDNYLLLGACLFGLMATNVGVGGLV----PKFLyDYFPLEVRGLGTGLIYNLAA-TSGTFNS 374
|
410
....*....|.
gi 692191013 398 FIAAALVTFSG 408
Cdd:PRK12307 375 MAATWLGITMG 385
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
70-432 |
4.69e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 82.24 E-value: 4.69e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 70 FGVGFLFRPLGGIIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFAsigwwapvLLVTLRAIQGFAVGGEWGGAALL 149
Cdd:cd17325 37 VAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYW--------QLLLARFLQGLASAAVWPAAMAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 150 SVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISQLttdeqflsWGWRIPFIFSIVLVVVALWIRNGMEEsaEFERQQ 229
Cdd:cd17325 109 IADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADA--------LGYRAPFLVCAALALLALVLALLLLP--EPRPPP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 230 REKPVAKKRLPVMEALVQHPGAFLKIIALRLCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLVVGGISCLTIPCFAWL 309
Cdd:cd17325 179 NKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 310 ADRFGRRRVYITGALIGTLSAWPFFMAleaqSVFWIVFFAIMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVgYQVAS 389
Cdd:cd17325 259 SDRIGRKPLILIGLLLSAVALLLLPLA----TSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGL-FNTAF 333
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 692191013 390 VVGGGFTPFIAAALVTFSGGNWhsvaIYLLAGCLLSAATALLM 432
Cdd:cd17325 334 SLGMVLGPLLGGFLYDAFGFAT----PFLAAAALLLLAAVLFL 372
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
59-430 |
1.95e-15 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 77.20 E-value: 1.95e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 59 PAMGTLAAFATFGVGflfrpLGGIIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFAsigwwapvLLVTLRAIQGFA 138
Cdd:cd17324 34 AQAGLLVSAYALGYA-----LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFA--------LLLLARALAGLA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 139 VGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISQLttdeqflsWGWRIPFIFSIVLVVVALWIrng 218
Cdd:cd17324 101 HGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQL--------LGWRAAFLAIAVLALLAALL--- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 219 meesaeferQQREKPVAKKRLPVMEALVQHPGAFLKIIALRLCELLTMYIVTAFALNYS------TQNLGLPRELFLNIG 292
Cdd:cd17324 170 ---------LWRLLPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTylapflTDVPGFSSSAIIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 293 LVVGGISCLTIPCFAWLADRFGRRRVYITGALIGTLSAWPFFMAleaqSVFWIVFFAIMLANIAHDMVVCVQQPMFTELF 372
Cdd:cd17324 241 LLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLG----PSPLLLLVGLVLWGLGFFAAHSALQTRVLRLA 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 692191013 373 GASyrYSGAGVGYQVASVVGGGFTPFIAAalVTFSGGNWHSVAIYLLAGCLLSAATAL 430
Cdd:cd17324 317 PEA--RGLASSLYLAAYNLGGALGAALGG--LVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
28-397 |
2.98e-15 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 76.69 E-value: 2.98e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 28 FAGAVVDWYDFLLYGITAALVFNREFfpQISPAMGTLAaFATFGVGFLfrpLGGIIFGHFGDRLGRKRMLMLTVWMMGIA 107
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDL--GISPTEIGLL-LTLFSLGYA---LAQPLAGRLSDRFGRRRVLLIGLLLFALG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 108 TALIGILPSFAsigwwapvLLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISQl 187
Cdd:pfam07690 76 LLLLLFASSLW--------LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 188 ttdeqflSWGWRIPFIFSIVLVVVALWIRNGMEESAEFERQQREKPVAKKRLPVMEALVQHPgaFLKIIALRLCELLTMY 267
Cdd:pfam07690 147 -------LFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDP--VLWLLLALLLFGFAFF 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 268 IVTAFALNYSTQnLGLPRELFLNIGLVVGGISCLTIPCFAWLADRFGRRRVYITGALIGTLSAWPFFMALEAQSVFWIVf 347
Cdd:pfam07690 218 GLLTYLPLYQEV-LGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLL- 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 692191013 348 FAIMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVgYQVASVVGGGFTP 397
Cdd:pfam07690 296 LALLLLGFGFGLVFPALNALVSDLAPKEERGTASGL-YNTAGSLGGALGP 344
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
22-404 |
6.10e-15 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 76.24 E-value: 6.10e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 22 RAALGSFAGAVVDWYDFLLYGITAALVfNREFfpQISPA-MGTLAAFATFGVGFlfrplGGIIFGHFGDRLGRKRMLMLT 100
Cdd:TIGR00895 17 RAIILSFLIMLMDGYDLAAMGFAAPAI-SAEW--GLDPVqLGFLFSAGLIGMAF-----GALFFGPLADRIGRRRVLLWS 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 101 VWMMGIATALIGILPSFASigwwapvlLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAF----YSSGVQVGYGVGLLL 176
Cdd:TIGR00895 89 ILLFSVFTLLCALATNVTQ--------LLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTavglMFCGYPIGAAVGGFL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 177 STGLVSLIsqlttdeqflswGWRIPFIF-SIVLVVVALWIRNGMEESAEFERQQREKPVAKKRLPVMEALVQHPGAFLKI 255
Cdd:TIGR00895 161 AGWLIPVF------------GWRSLFYVgGIAPLLLLLLLMRFLPESIDFLVSKRPETVRRIVNAIAPQMQAEAQSALPE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 256 ----------------------IALRLCELLTMYIVTAFALN------YSTQNLGLPRELFLNIGLVVGGISCLTIpcFA 307
Cdd:TIGR00895 229 qkstqgtkrsvfkalfqgktarITVLLWLLYFMLLVGVYFLTnwlpklMVELGFSLSLAATGGALFNFGGVIGSII--FG 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 308 WLADRFGRRRVYITGALIGTLSAWPFFMALEAQSVFWIVFFAIMLANIAHDMVVCVQqpmfTELFGASYRYSGAGVGYQV 387
Cdd:TIGR00895 307 WLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALM----ALFYPTAIRATGVGWAIGI 382
|
410
....*....|....*..
gi 692191013 388 ASvVGGGFTPFIAAALV 404
Cdd:TIGR00895 383 GR-LGAIIGPILAGYLL 398
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
70-436 |
5.79e-13 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 70.43 E-value: 5.79e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 70 FGVGFLfrpLGGIIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFasigwwaPVLLVtLRAIQGFAVGGEWGGAALL 149
Cdd:TIGR00898 136 FFVGVL---LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNY-------TVFLV-FRLLVGMGIGGIWVQAVVL 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 150 SVESAPKNKKAFYSSGVQVGYGVGLLlstgLVSLISQLTTDEQFLSWGWRIPFIFSIVLVvvaLWIrngmEESAEFERQQ 229
Cdd:TIGR00898 205 NTEFLPKKQRAIVGTLIQVFFSLGLV----LLPLVAYFIPDWRWLQLAVSLPTFLFFLLS---WFV----PESPRWLISQ 273
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 230 RE--------KPVAKK----------RLPVMEALVQHPGAFLKII-----ALRLCELLTMYIVTAFALNYSTQNLGLPrE 286
Cdd:TIGR00898 274 GRieealkilQRIAKIngkklpaevlSLSLEKDLSSSKKQYSFLDlfrtpNLRKTTLCLMMLWFTTAFSYYGLVLDLG-N 352
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 287 LFLNI--GLVVGGISCLTIPCFAWLA-DRFGRRRVYITGALIGTLSAwpFFMALEAQSVFWI----VFFAIMLANIAHDM 359
Cdd:TIGR00898 353 LGGNIylDLFISGLVELPAKLITLLLiDRLGRRYTMAASLLLAGVAL--LLLLFVPVDLYFLrtalAVLGKFGITSAFQM 430
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 692191013 360 VVcvqqpMFT-ELFGASYRYSGAGVGyQVASVVGGGFTPFIAaalvtFSGGNWHSVAIYLLAG-CLLSAATALLMKETT 436
Cdd:TIGR00898 431 VY-----LYTaELYPTVVRNLGVGVC-STMARVGSIISPFLV-----YLGEKWLFLPLVLFGGlALLAGILTLFLPETK 498
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
57-433 |
2.46e-12 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 67.98 E-value: 2.46e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 57 ISPAMGTLAAFATFGVGFLFRPLGGIIfghfGDRLGRKRMLMLTVWMMGIATALIGILPSFAsigwwapvLLVTLRAIQG 136
Cdd:cd17474 31 ASPAQVGLLITAFTLPAAVLMPVAGVL----ADRFGRKKVLLPGLLLFGIGGLLCGLSDSFA--------LLLAGRALQG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 137 FAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISqlttdeqflSWGWRIPFIFSIVLVVVALWIR 216
Cdd:cd17474 99 IGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA---------AISWRYPFFLLAALIPVAFLAI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 217 NGMEESaeferQQREKPVAKKRLPVMEALVQHPGAFLKIIALRLCellTMYIVTAFaLNYSTQNLGLPRELF-LNIGLVV 295
Cdd:cd17474 170 LFLLPE-----PKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFL---YFFLYFAF-LTYLPFLLELLYGISpIIIGLLF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 296 GGIS---CLTIPCFA-WLADRFGRRRVYITGALIGTLSawpfFMALEAQSVFWIVFFAIMLANIAHDMVVCVQQPMFTEL 371
Cdd:cd17474 241 AGWSvllALGSLFVGrLLKKRFGARRILVIGLLLYALS----LLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTEL 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 692191013 372 FGASYRYSGAGVgYQVASVVGGGFTPFIAAALVTFSGGNWhsvaIYLLAGCLLSAATALLMK 433
Cdd:cd17474 317 APEEERGTASSL-YNFVRFLGQAVGPLLFGLLLEIFGLSA----PFLVGAAIALAAAVLLAL 373
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
66-432 |
2.48e-12 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 67.61 E-value: 2.48e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 66 AFATFGVGFLFrplGGIIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFAsigwwapvLLVTLRAIQGFAVGGEWGG 145
Cdd:cd17317 30 VQTIFFLGVLI---GSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYE--------LFLVLRFLVGVTSAGIFTV 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 146 AALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISqlttDEQFLSWGWRIPFIFSIVLvvvaLWIrngmeesaef 225
Cdd:cd17317 99 GFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIR----DWRWLQLAISLPGLLFLLL----LWW---------- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 226 erqqrekpvakkrLPVmealvqhpgaflKIIALRLCELLTMyiVTAFALNYSTQNLGlpRELFLNIgLVVGGISCLTIPC 305
Cdd:cd17317 161 -------------LPR------------RTIIVGLIWFVTS--LVYYGLSLNSSNLG--GNLYLNF-FLSGLVEIPAYFL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 306 FAWLADRFGRRRVYITGALIGTLSAWPFFMALEAQSVFWIVFFaiMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVGY 385
Cdd:cd17317 211 ALLLLDRLGRRWTLSGSLLLAGLACLVTALLPDDENTLALTLA--LVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCS 288
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 692191013 386 QVASvVGGGFTPFIaaalvTFSGGNWHSVAIYLLAGCLLSAATALLM 432
Cdd:cd17317 289 TVAR-VGAILAPFI-----VLLGKIGPLLPLIIFGVLALLGGLLTLL 329
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
70-424 |
1.12e-11 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 65.91 E-value: 1.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 70 FGVGFLFRPLGGIIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFAsigwwapvLLVTLRAIQGFAVGGEWGGAALL 149
Cdd:cd06174 37 FALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFW--------LLLLGRFLLGLGSGLIDPAVLAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 150 SVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISQlttdeqFLSWGWRIPFIFSIVLVVVALWIRNGMEESAEFERQQ 229
Cdd:cd06174 109 IADLFPERERGRALGLLQAFGSVGGILGPLLGGILAS------SLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 230 REKPVAKKRLPVMEALVQHPGAFLKIIALRLCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLVVGGISCLTIPCFAWL 309
Cdd:cd06174 183 KNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 310 ADRFGRRRV--YITGALIGTLSAWPFFMALEAQSVFWIVFFAIMLANIAHDMVVCVQQPMFTELFGASyrYSGAGVGYQV 387
Cdd:cd06174 263 SDRLIGRKPllLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTA--FGLLNTFGFL 340
|
330 340 350
....*....|....*....|....*....|....*..
gi 692191013 388 ASVVGGGFTPFIAAALVTFSGGNWHSVAIYLLAGCLL 424
Cdd:cd06174 341 GGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
27-367 |
6.33e-11 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 63.73 E-value: 6.33e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 27 SFAGAVVDWYDFLLYGITAALVFNReffpQISPAMGTLAAFATFGVGFLFRPLggiiFGHFGDRLGRKRMLMLTVWMMGI 106
Cdd:cd17478 2 SLGHFLNDFYQGFLPALLPLLIAKL----GLSYAQAGLLVSVFSITSSLLQPL----FGYLADRKPRRYLLPLGPLLTGL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 107 ATALIGILPSFAsigwwapvLLVTLRAIQGFAVGG-EWGGAALLSVESAPKNKKA--FYSSGVQVGYGVGLLLSTGLVSL 183
Cdd:cd17478 74 GLSLLGFAPNYW--------LLLLLVALAGIGSAAfHPEGARLASQAAGGRRGLAmsIFSVGGNLGFALGPLIAAALVAL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 184 ISqlttdeqFLSWGWRIPFIFSIVLVVVALWIRngmeesaefeRQQREKPVAKKRLPVMEALVQHPGAFLKIIALRLCEL 263
Cdd:cd17478 146 FG-------GLGLLILLIIPGLAVALLLLRLRP----------LKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRS 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 264 LTMYIVTAFALNYSTQNLGLPRE--LFLNIGLVVGGISCLTipcFAWLADRFGRRRVYITGALIGTLSAWPFFMALEAQS 341
Cdd:cd17478 209 WVLSSLTTFLPFYLVQRGYSLVFagLLLSLFLFAGAIGTLI---GGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWS 285
|
330 340
....*....|....*....|....*.
gi 692191013 342 VFWIVFFAIMLANIAHDMVVCVQQPM 367
Cdd:cd17478 286 YILLVLAGFLLFASFPVTVVLAQELL 311
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
27-430 |
8.70e-10 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 60.43 E-value: 8.70e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 27 SFAGAVVDWYDFLLYGITAALVFNREFFPQISPAMGTLAAFATFGVGFLFRPLGGIIFGHFGDRLGRKRMLMltvwMMGI 106
Cdd:TIGR00879 34 AIGGLMFGYDTGVIGGALALPAFEFKFTSANSDSYSSSLWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLL----IIAL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 107 ATALIGILPSFASIGWWAPVLLVTlRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISQ 186
Cdd:TIGR00879 110 LFVIGAILMGLAAFALSVEMLIVG-RVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGFGSGKVS 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 187 LTTDEQF-----LSWGWRIPFIFSIVLVVVALW--IRNGMEESAEFERQ------------QREKPVAKKRLPVMEALVQ 247
Cdd:TIGR00879 189 LNNTLGWriplgLQLIPAGLLFLGLFFLPESPRwlVGKGRVEEARKSLArlrgtsgedkelLDELELIDIKRSIEKRSVQ 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 248 HPGAFLKIIALRLCELLTMYIVTAFA---------LNYST---QNLGLPRELFLNIGLVVGGISCLTIPCFAWLADRFGR 315
Cdd:TIGR00879 269 PSWGSLFSSTRRIRRRLFLGVVLQWFqqftginaiMYYSPtifENAGVSTDHAFLVSIIVGAVNFAFTFVAIFLVDRFGR 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 316 RRVYITGALIGTLSAW----PFFMAL--EAQSVFWIVFFAIMLANIAHDM-VVCVQQPMFTELFGASYRYSG---AGVGY 385
Cdd:TIGR00879 349 RPLLLIGAAGMAICLFvlgiLGASFVtgSSKSSGNVAIVFILLFIAFFAMgWGPVPWVIVSEIFPLSLRPKGisiAVAAN 428
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 692191013 386 QVASVVGGGFTPFIAAALvtfsggnwHSVAIYLLAGCLLSAATAL 430
Cdd:TIGR00879 429 WLANFIVGFLFPTMLESI--------GVGGVFIFFGGLNVLGLIF 465
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
70-432 |
1.52e-09 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 59.59 E-value: 1.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 70 FGVGFLFRPLGGIIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFASigwwapvlLVTLRAIQGFAVGGEWGGAALL 149
Cdd:PRK11551 56 FSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPS--------LLVARLLTGVGLGGALPNLIAL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 150 SVESAPKNKKafySSGVQVGYgVGLLLSTGLVSLISQLTTDEQflswGWRIPFIFSIV--LVVVALWIRNgMEESAEFer 227
Cdd:PRK11551 128 TSEAVGPRLR---GTAVSLMY-CGVPFGGALASVIGVLAAGDA----AWRHIFYVGGVgpLLLVPLLMRW-LPESRAF-- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 228 qQREKPVAKKRLPVMEALVQhPGAFLKIIALRLCELLTMyIVTAFALNYSTQNL---GLPR------ELFLNIGlvvGGI 298
Cdd:PRK11551 197 -AQAAGAGKQRAPVLRALFG-EGRATATLLLWISYFFTL-IVLYFLLNWLPSLLvgqGLSRsqaglvQIAFNIG---GAL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 299 SCLTIpcfAWLADRFGRRRVyITGALIGTLSAwpffMALEAQSVfwiVFFAIMLANIAHDMVVCVQQPMFTELFGASYRY 378
Cdd:PRK11551 271 GSLLI---GALMDRLRPRRV-VLLIYAGILAS----LAALAAAP---SFAGMLLAGFAAGLFVVGGQSVLYALAPLFYPT 339
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 692191013 379 S--GAGVGYQVA-----SVVGggftPFIAAALVTfSGGNWHSVAIYLLAGCLLSAATALLM 432
Cdd:PRK11551 340 QvrGTGVGAAVAvgrlgSMAG----PLLAGQLLA-LGRSTVGVIGASIPVILVAALAALLL 395
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
41-352 |
7.56e-08 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 54.16 E-value: 7.56e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 41 YGITAALVFNREFFpQISPAMGTLAAFAtFGVGFLfrpLGGIIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFasi 120
Cdd:cd17328 16 FTIAGVLPDIQSDF-LIDDSLAGLLQTV-FIISYM---VLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNF--- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 121 gWWapvlLVTLRAIQGFavgGEWGGAAL---LSVESAPKNKK----AFYSSGVQVGYGVGLLLStglvSLISQLTTDEQf 193
Cdd:cd17328 88 -WQ----LLLFRALVGI---GEASYSPIaptIIADLFPKEKRtralGVFYFAIPLGSGLGYVVG----GLVAQATGGWR- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 194 lsWGWRIPFIFSIVLVVVALWIRnGMEESAEFERQQREKPVAKKRLPVMEALVQHPgAFLKIIALRLCELLTMYIVTAFA 273
Cdd:cd17328 155 --WAFRVTGVLGVLLAILLLLFV-REPPRGAAEGGVMAKSTATSFLADLKALAKNP-SFILSTLGFTAVSFVTGALAFWA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 274 LNYSTQNLGLPRELFLNIGLVVGGISCLT----IPCFAWLADRFGRR--RVYITGALIGTLSAWPF-FMALEAQSVFWIV 346
Cdd:cd17328 231 PTFFLRAFGVGDLSSADVGLIFGAITCIAgvlgVLLGGILADRLRRKtpRADPLVCAVGLLAAAPFlFLALVLALSNLLL 310
|
....*.
gi 692191013 347 FFAIML 352
Cdd:cd17328 311 AWVLLF 316
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
57-431 |
2.18e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 52.58 E-value: 2.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 57 ISPAMGTLAAFATFGVGF----------LFRPLGGIIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFasigwwaPV 126
Cdd:cd17473 18 IAPALPAIAQHFVPNSELlvpllltlpaLFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSL-------YA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 127 LLVTlRAIQGFAVGGEWGGA-ALLSV--ESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLIsqlttdeqflswGWRIPFI 203
Cdd:cd17473 91 LLAS-RALLGIGVAGIMTLAtALIGDyfEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI------------GWRAPFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 204 F----SIVLVVVALWIRNGMEESAEFERQQREKPVAKKRLPVmealvqhpgafLKIIALRLCELLTMYIVTAFALNYSTQ 279
Cdd:cd17473 158 VyllaLPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRV-----------LPIYFLAFLAMLLFYVIPIQLPFLLQE 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 280 NLGLPRELFLNIGLVVGGISCLTIPCFAWLADRFGRRRVYITGALIGTLSawpfFMALEAQSVFWIVFFAIMLANIAHDM 359
Cdd:cd17473 227 RGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALG----FLLLALASGLWVVLLGAILAGLGFGL 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 692191013 360 VVCVQQPMFTELFGASYRysGAGVGYQVASVVGGGF-TPFIAAALVTFSGGnwHSVAIYLLAGCLLSAATALL 431
Cdd:cd17473 303 LLPTLNSWAMSLVPPELR--GRAMGIVTSAFFLGQFlSPLVLGPLVNLTGG--LSGAFLILGVLALVLAIVLL 371
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
56-424 |
3.49e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 52.16 E-value: 3.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 56 QISPAMGTLAAFAtFGVGFLfrpLGGIIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFAsigwwapvLLVTLRAIQ 135
Cdd:COG0738 39 GLSDAQAGLLLFA-FFLGYL---LASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYP--------LLLLALFLL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 136 GFAVGGEWGGAALLSVESAPKNKKAFYSSGvQVGYGVGLLLSTGLVSLISQLTtdeqfLSWGWRIPF-IFSIVLVVVALW 214
Cdd:COG0738 107 GLGLGLLDVAANPYVAALGPETAASRLNLL-HAFFSLGALLGPLLGGLLILLG-----LSLSWHLPYlILAVLLLLLALL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 215 IRngmeeSAEFERQQREKPVAKKRLPVMEALVQHPGAFLKIIALrLCELLTMYIVTAFALNYSTQNLGLPREL------F 288
Cdd:COG0738 181 FL-----RSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAI-FLYVGAEGAIGDWLPLYLKDVLGLSEATaalglsL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 289 LNIGLVVGGISCltipcfAWLADRFGRRRVYITGALIGTLSAWPFFMAleaqSVFWIVFFAIMLANIAHDMVVCVQQPMF 368
Cdd:COG0738 255 FWGGMTIGRFLG------GFLLKRFGPVRLLRLSALLAAVGLLLALLA----PGPWLALIGLALVGLGLSLMFPTIFSLA 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 692191013 369 TELFGasyRYSGAGVGYQ-VASVVGGGFTPFIAAALVTFSGGNWhsvAIYLLAGCLL 424
Cdd:COG0738 325 LDGLG---KRTAAAVSAVlIMGIVGGAIGPPLIGFLADAFGLRA---AFLVPLVCYL 375
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
31-437 |
4.24e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 51.82 E-value: 4.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 31 AVVDWYDFLLYGITAALVFnREFfpQISPA-MGTLAAFATFGVGflfrpLGGIIFGHFGDRLGRKRMLMLTVWMMGIATA 109
Cdd:cd17365 8 IVLDGFDLAVMGFVAPALA-QDW--GLSPAqLGPVGSAALFGMA-----IGALLAGPLADRFGRKRVLLVSVALFGLFTL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 110 LIGILPSFASigwwapvlLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISQltt 189
Cdd:cd17365 80 LTAFAQSVLQ--------LALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIP--- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 190 deqflSWGWRIPFIFSIVLVVVAlwirngmeesaeferqqrekpvakkrLPVMealvqhpGAFLKIIALRLCELLTMYIV 269
Cdd:cd17365 149 -----AFGWRSVFLLGGVPPLIL--------------------------LPLL-------RGTLLLWVTFFMGLLLVYLL 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 270 TAFaLNYSTQNLGLPRE------LFLNIGLVVGGIscltipCFAWLADRFGRRRVYITGALIGTLSAwpfFMALEAQSVF 343
Cdd:cd17365 191 NSW-LPKLMVEAGYSLSqaltitLLLNIGGVIGSL------LLGWLADRFGPKRVLALFFALGAVSL---ALLGVSPASL 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 344 WIVFFAIMLANIAHDMVVCVQQPMFTELFGASYRysGAGVGYQVA-SVVGGGFTPFIAAALVTFSGGnwHSVAIYLLAGC 422
Cdd:cd17365 261 VLLYVLVFLAGACVNGAQVGLYALAARFYPTEVR--ATGVGWALGvGRLGAILGPLLGGLLLAAGLG--PESVFLALAIP 336
|
410
....*....|....*
gi 692191013 423 LLSAATALLMKETTH 437
Cdd:cd17365 337 AALGALAVLLLRLRR 351
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
167-371 |
4.70e-07 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 51.84 E-value: 4.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 167 QVGYGVGLLLSTGLVSLISQLTTDEQFLSWGWRIPFIFSIVLVVVALWIRNGMEESAEFERQQREKPVAKKRLpvmeALV 246
Cdd:cd17332 142 MFFATIGGLLVTVLPPPLVAYFGGGNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKLPLLKSL----KAL 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 247 QHPGAFLKIIALRLCELLTMYIVTAFALNYSTQNLGlPRELFLNIGLVVGGISCLTIPCFAWLADRFGRRRVYITGALIG 326
Cdd:cd17332 218 LKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLG-GRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLA 296
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 692191013 327 TLSAwPFFMALEAQSVFWIVFFAImLANIAHDMVVCVQQPMFTEL 371
Cdd:cd17332 297 ILGL-LLLFFLPPGNLVLILVLAV-LAGIGYGGANLLPWAMLADV 339
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
58-433 |
4.95e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 51.46 E-value: 4.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 58 SPAMGTLAAFATFGVGFLFrplgGIIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFASIGWWAPVLLVTLRAIQGF 137
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLF----SPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 138 AVGGEWGGA--ALLSVESAPKNkKAFYSSGVQVGYGVGLLLSTGLVSLisqlttdeqflsWGWRIPFIFSIVLVVVALWI 215
Cdd:cd06173 108 FFGPARQALlpELVPKEQLVRA-NALNSLATQLARIIGPALGGLLVAL------------LGPGGAFAINALSFLLSALL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 216 RNGMEESAEFERQQREKPVAKKRLPVMEALVQHPGAFLKIIALRLCELLTMYIVTAFALnYSTQNLGLPRELF------L 289
Cdd:cd06173 175 LLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPL-LAKEVLGGGAAGYglllaaF 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 290 NIGLVVGGISCltipcfAWLADRFGRRRVYITGALIGTLSAWPFFMAleaqSVFWIVFFAIMLANIAHDMVVCVQQPMFT 369
Cdd:cd06173 254 GVGALLGALLL------GRLSKRRRRGRLLLIGALLLGLALLVLGLS----PSLWLLLAALFLLGLAGGLFNVPLNTLLQ 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 692191013 370 ELFGASYRysgaGVGYQVASVVGGGFTPfIAAALVTFSGGNWHSVAIYLLAGCLLSAATALLMK 433
Cdd:cd06173 324 LRVPDELR----GRVFSVYNALNSGAMP-LGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
69-328 |
5.82e-07 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 51.50 E-value: 5.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 69 TFGVGFLFRPLGGIIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFasigWWapvlLVTLRAIQGFaVGGEWGGAAL 148
Cdd:cd17391 41 AFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNV----WQ----LLILRLLQGV-FSGYVPNATA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 149 LSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISQLTtdeqflswGWRIPF-IFSIVLVVVALWirngmeeSAEFER 227
Cdd:cd17391 112 LIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLF--------GIRNVFfITGGLLFLAFLL-------TLFFVK 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 228 QQREKPVAKKRLPVMEAL--VQHPGAFLKIIALRLCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLVV---GGISCLT 302
Cdd:cd17391 177 EDFKPVEKKKMVSTKEVWnsVPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQLMGDASNLAFISGLVFsatGVSSLLS 256
|
250 260
....*....|....*....|....*.
gi 692191013 303 IPCFAWLADRFGRRRVYITGALIGTL 328
Cdd:cd17391 257 APRLGKLGDRIGHHRILLGALLASAL 282
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
68-427 |
7.39e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 51.02 E-value: 7.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 68 ATFGVGFLfrpLGGIIFGHFGDRLGRKRMLMLtvwMMGIATALIGILPSFASIGWWAPvllvtLRAIQGFAVGGEWGGAA 147
Cdd:cd17477 38 SAYYLGIL---LGSPLVPRLIRRVGHIRAFAA---GAAITAVSVLLLALTDSPWVWFL-----LRFVMGIGLAGLFVVSE 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 148 LLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISQLttdeqflswGWRiPFIFSIVLVVVALWIrNGMEESAEFER 227
Cdd:cd17477 107 SWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTA---------GAL-PFLIAAVLLLLALVP-LLLTRRAAPEI 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 228 QQREKpvakkrLPVMEALVQHPGAFLKIIALRLCE--LLTMYIVTAFALNYSTQNLGLPRELFlniglVVGGIsCLTIPc 305
Cdd:cd17477 176 EEAES------ISLRRLLRIAPLALLGAFVAGFLEgaFYSLLPLYGLRLGLSVAQAALLLAAF-----VLGGL-LLQWP- 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 306 FAWLADRFGRRRVYITGALIGTLSAWPFFMALEAQSVFWIVFFaimlaniahdMVVCVQQPMFT-------------ELF 372
Cdd:cd17477 243 LGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLF----------LWGGAAGPLYTlalalagdrlpgdELV 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 692191013 373 GASyrySGAGVGYQVASVVGggftPFIAAALVTFSGGNWHSVAIYLLAGCLLSAA 427
Cdd:cd17477 313 AAN---AALLLLYGLGSVIG----PLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
68-184 |
9.05e-07 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 50.43 E-value: 9.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 68 ATFGVGFLFrplGGIIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFASIgwwapvllVTLRAIQGFAVGGEWGGAA 147
Cdd:cd17379 40 SSLNLGFLI---GSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWF--------LIFRFLQGLFGKGGWMTGY 108
|
90 100 110
....*....|....*....|....*....|....*..
gi 692191013 148 LLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLI 184
Cdd:cd17379 109 VLVTEFVGSKYRRTVGIVYQMFFTLGLLILPGIAYFI 145
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
80-216 |
1.39e-06 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 50.35 E-value: 1.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 80 GGIIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFASIGwwAPVLLVTLRAIQGFAVGGEWGGAALLSVESAPKNKK 159
Cdd:cd17364 55 GQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGSTPLG--VMGWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRR 132
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 692191013 160 AFYSSGVQVGYGVGLLLStGLVSLISQLTTDEQF-------LSWGWRIPFIFSIVLVVVALWIR 216
Cdd:cd17364 133 GALIAAVFAMQGFGILAG-AIVTLILSAIFEHPLpagtyhhADLVWRIVLGLGAIPALSVLYFR 195
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
68-225 |
1.67e-06 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 50.11 E-value: 1.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 68 ATFGVGFLFRPLGGIIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFASIGWWApvLLVTLRAIQGFAVGGEWGGAA 147
Cdd:TIGR00887 60 AVNGSASIGTLAGQLFFGWLADKLGRKRVYGMELIIMIIATVASGLSPGSSPKSVMA--TLCFWRFWLGVGIGGDYPLSA 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 148 LLSVESAPKNKKAFYSSGVQVGYGVGlLLSTGLVSLISQLTTDEQF----------------LSWGWRIPFIFSIVLVVV 211
Cdd:TIGR00887 138 IITSEFATKKWRGAMMAAVFAMQGFG-ILAGAIVALIVLAGFKHSLeaaadeasctgscvpaVDYMWRILIGFGAVPALL 216
|
170
....*....|....
gi 692191013 212 ALWIRNGMEESAEF 225
Cdd:TIGR00887 217 ALYFRLTIPETPRY 230
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
27-328 |
1.84e-06 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 49.94 E-value: 1.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 27 SFAGAVVDWYDFLLYGITAALVFNREF-----FPQISPA-MGTLAAFATFGVGFlfrplGGIIFGHFGDRLGRKRMLmlt 100
Cdd:cd17356 7 SLGGFLFGYDTGSISGILNMKSFQKYFadntgTYYPSSSrQGLIVSIVNLGSFF-----GALISSFLSDRIGRKKSI--- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 101 vwMMGIATALIGILPSFASIGWWAPVLLVtlRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLllstgL 180
Cdd:cd17356 79 --QIGCVIYIIGAIIQVAAIGKWYQLIVG--RIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGI-----L 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 181 VSLISQLTTDEQFLSWGWRIP----FIFSIVLVVVALWIrngmeesaeferqqREKPVAKKRLPV---MEALVQHPGafl 253
Cdd:cd17356 150 VAYCINYGTHKLDGSAQWRIPlglqIVWGLLLLIGMFFL--------------PESPRWLYRTILgimLQLFQQLTG--- 212
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 692191013 254 kiialrlCELLTMYIVTAFalnystQNLGLPRELFLNIGLVVGGISCLTIPCFAWLADRFGRRRVYITGALIGTL 328
Cdd:cd17356 213 -------INYFFYYGTTIF------QSTGLTGSSPLLTSIILYIVNFVSTIPGLFFVDKFGRRTCLLIGAAGMSI 274
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
58-432 |
3.23e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 49.13 E-value: 3.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 58 SPAMGTLAAFATFGVGFLFRPLGGIIfghfGDRLGRKRMLMLTVWMMGIATALIGILPSFAsigwwapvLLVTLRAIQGF 137
Cdd:cd17489 29 SEAVAGLVVGLFTLAALLARPFAGRL----LDRFGRKRLLLIGLLIFALATLLYLLATSVA--------LLLVLRLIHGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 138 AVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISQLttdeqflsWGWRIPFIFSIVLVVVALWIRN 217
Cdd:cd17489 97 GWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQH--------LGFAVLFIVAAVLALLALLLVF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 218 GM-EESAEFERQQREKPVAKKRLPVMEALVqhPGAFLKIIALRLCELLTMYIVTAFALNYStqnlglprelflNIGL--- 293
Cdd:cd17489 169 LVkDPPPVAAEEAEAGTRAFRRLVEKKVLP--PALILFLASIAYGAISTFLPLYAAERGIS------------NAGLfft 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 294 VVGGISCLTIPCFAWLADRFGRRRVYITGALIGTLSAWPFFMaleAQSVFWIVFFAIMLAnIAHDMVvcvqQPMFTELFG 373
Cdd:cd17489 235 VYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSF---AGSPWMLLLAAVLYG-LGFGLL----FPALQALAV 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 692191013 374 ASYRYSGAGVG---YQVASVVGGGFTPFIAAALVTFSGgnwhSVAIYLLAGCLLSAATALLM 432
Cdd:cd17489 307 DLVPPHRRGAAngtFFIFFDLGIGLGGLLLGLVAELFG----YRAMFLLAAVVVLLALVLYI 364
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
79-432 |
4.29e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 48.76 E-value: 4.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 79 LGGIIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFASIGWWApvllvtlrAIQGFAVG-GEWGGAALLSVESAPKN 157
Cdd:cd17329 50 VASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIAL--------VLTGFGGGlFEPASEAMIADVTTPEN 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 158 KKAFYSS---GVQVGYGVGLLLSTGLVSLISQLTTdeqflswgWRIPFIFSIVLVVVALWIRngmeESAEFERQQREKPV 234
Cdd:cd17329 122 RTRAFSLlywAINLGVAIGPLLGGLLLLYSFRLLF--------LAAAVLFLLAALVLLFLLP----ETRPKRRAAEKTEI 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 235 AKKRLPVMealvQHPGAFLKIIALRLCELLTMYIVTAFALnYSTQNLGLPRELFLNIGLVVGGISCLTIPCFAWLADRFG 314
Cdd:cd17329 190 LRGYKIVL----RDRAFLLFLLASFLISLIYFQLESTLPV-YVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFR 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 315 RRRVYITGALIGTLSawpFFMALEAQSVFWIVFFAIMLAnIAHDMVVCVQQPMFTELFGASYR--YSGAgvgYQVASVVG 392
Cdd:cd17329 265 LRKILMIGILLFAIG---FAVLAFANTLAVLILAMIVLT-LGEMLVFPAVQTLVAALAPPDKRgsYMGF---YALAWGLG 337
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 692191013 393 GGFTPFIAAALVTFSGGNWhsVAIYLLAGCLLSAATALLM 432
Cdd:cd17329 338 RAIGPLVGGLLLDLLGPGL--PWLILAALGLIAAALLLGL 375
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
45-431 |
4.33e-06 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 48.34 E-value: 4.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 45 AALVFNREFfpQISPAMGTLAAFATFGVGFLFRPLGGIifghFGDRLGRKRMLMLTVWMMGIATALIGILPSFASigwwa 124
Cdd:cd17319 25 AAPTIMKDL--GLSPTQYGLIASAFFLGYALFQVPGGW----LLDRFGARKVLAVSMLLWSLFTALTGFATSLTS----- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 125 pvlLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKA----FYSSGVQVGYGVGLLLSTGLVSLisqlttdeqflsWGWRI 200
Cdd:cd17319 94 ---LYVLRFLLGVAEAGFFPGAIKALAEWFPARERGratgLFNSGAPLGAAIGPPLSGWLLLL------------FGWRW 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 201 PFIFSIVLVVVALWirngmeesaeferqqrekpVAKKRLPVMealvqhpgafLKIIALRLCELLTMYIVTAFALNYSTQN 280
Cdd:cd17319 159 AFIIEGLLGLLLAV-------------------LWWFYLRQV----------WGLALGYFGINYALYGLLTWLPTYLKQA 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 281 LGLPRE---LFLNIGLVVGGISCLTIPcfaWLADRF--GRRRVYITGALIGTLSAWPFFMALEAqsvFWIVFFAIMLANI 355
Cdd:cd17319 210 RGFSLKqvgLLAAIPFLAGAIGMILGG---RLSDRLlrGARRLVIIIGLLLAAVGLLLAYLTTS---PVVAVILLSLAGF 283
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 692191013 356 AHDMVVCVQQPMFTELFGASYRYSGAGVgYQVASVVGGGFTPFIAAALVTFSGGnwHSVAIYLLAGCLLSAATALL 431
Cdd:cd17319 284 GIGAASPVFWSLPADLLPGEAAATAGGL-INSGGNLGGFVAPLLIGYLVDATGS--YTAAFLFLAAVALLAALLVL 356
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
85-353 |
8.17e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 47.57 E-value: 8.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 85 GHFGDRLGRKRMLMLTVWMMGIATALIGILPSFASigwwapvlLVTLRAIQGFAVGGEWGGAALLSVESAPKNKK----A 160
Cdd:cd17503 52 GWLADRFGTRRLFLTALALFTLGSLLCGLAPNLAS--------LIIFRILQGFGGGVLIPLAQTILLRIYPPEKRgaamG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 161 FYSSGVQVGYGVGLLLSTGLVSlisqlttdeqflSWGWRIPFIFSIVLVVVALWIrngmeesaeferqqrekpvakkrLP 240
Cdd:cd17503 124 LVGLVILLAPAIGPTLGGWLTD------------NLSWRWIFYINLPIGILALLL-----------------------AP 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 241 VME-ALVQHPGAFLKIIALRLCELLTMYIVTAFALnYSTQNLGLPRelfLNIGLVV--GGI-SCLTIPCFAWLADRFGRR 316
Cdd:cd17503 169 LLDlRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPL-YLQNVLGYSA---FESGLVLapGGLaSAILSPLVGRLLDKFGPR 244
|
250 260 270
....*....|....*....|....*....|....*..
gi 692191013 317 RVYITGALIGTLSAWPFFMALEAQSVFWIVFFAIMLA 353
Cdd:cd17503 245 LLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRG 281
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
56-432 |
1.25e-05 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 47.30 E-value: 1.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 56 QISPAMGTLAAFATFGVGFLFRPLGGIIFGHFGDRLGRKRMLMLtvwmMGIATALIGILPSFASIGW-------WAPVLL 128
Cdd:pfam13347 29 GLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLL----LSAIILAVSFILLFTPPELgraplfiWLLATY 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 129 VTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGV-GLLLSTGLVSLISQLTTDEQflswGWRIPFIFSIV 207
Cdd:pfam13347 105 ILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLlAAALAFPLVLILGGTGLERK----GYRIFALIGAV 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 208 LVVVALWIR-NGMEESAEFERqqREKPVAKKRLPVMEAL--VQHPGAFLKIIALRLCELLTMYIVTAFALNYSTQNLGLP 284
Cdd:pfam13347 181 LMLLGVIITaAGTKERVSMRS--KEDTGQKEAGSLLDMLkeVFRNRAFLILLASFLLAALAMGVLNGLLLYYFRYVLGNG 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 285 RElFLNIGLVVGGISCLTIPCFAWLADRFGRRRVYITGALIgTLSAWPFFMALEAQSVfWIVFFAIMLANIAHDMVVCVQ 364
Cdd:pfam13347 259 FA-ASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALI-TIAGFALALLLGPNNT-LLFLVLYIIIGFGYGSSFFLP 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 365 QPMFTELFGASYRYSG---AGVGYQVASVV---GGGFTPFIAAALVTFSGGNWHSVAI-----------YLLAGCLLSAA 427
Cdd:pfam13347 336 WSMLADVVDYGELRTGkrrEGTFFAMWSFIsklATGVGLGVSGLLLSAFGYNAGDSVQspqavtairllYAVLPAVLFLV 415
|
....*
gi 692191013 428 TALLM 432
Cdd:pfam13347 416 ALLLL 420
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
255-434 |
2.56e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.87 E-value: 2.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 255 IIALRLCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLVVGGISCLTIPCFAWLADRFGRRRVYITGALIGTLSAWPFF 334
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 335 MAleaqSVFWIVFFAIMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVgYQVASVVGGGFTPFIAAALVTFSGgnWHSV 414
Cdd:pfam07690 81 FA----SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGL-VSAGFGLGAALGPLLGGLLASLFG--WRAA 153
|
170 180
....*....|....*....|
gi 692191013 415 AIYLLAGCLLSAATALLMKE 434
Cdd:pfam07690 154 FLILAILSLLAAVLLLLPRP 173
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
79-222 |
2.58e-05 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 46.03 E-value: 2.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 79 LGGIIFGHFGDRLGRKRMLMLTvwmmgIATALIGILPSFASIGWWApvlLVTLRAIQGFAVGGEWGGAALLSVESAPKNK 158
Cdd:cd17315 49 IGSLFGGPLADRFGRRKSLLIA-----AVLYVIGALLSALAPNVWV---LIVGRFLLGLGVGLASVLVPLYISEIAPAKI 120
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 692191013 159 KAFYSSGVQVGYGVGLLLSTGLVSLISQLttdeqfLSWGWRIPFIFSIVLVVVALWIRNGMEES 222
Cdd:cd17315 121 RGALGTLNQLMITFGILLAYLLGLALSLS------PPGWWRLMFALAAVPALLQLLLMFFLPES 178
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
56-433 |
4.17e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 45.65 E-value: 4.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 56 QISPAMGTLAAFATFGVGFLFRPlggiIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFasigwwaPVLLVtLRAIQ 135
Cdd:cd17504 27 GTSAAAVSWVLTAYLLVGAVSTP----ILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNL-------PVLIA-GRALQ 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 136 GFAVGGEWGGAALLSVESAPKNKK---AFYSSGVQVGYGVGLLLStglvSLISQLttdeqflsWGWRIPFIFSIVLVVVA 212
Cdd:cd17504 95 GIGGAVFPLAFALVREEFPPERVPvaqGILSATFGIGAGIGLPLG----GWIVQH--------LGWRWIFWTAAPVAVLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 213 LWIrngmeesaeferqqrekpvakkrLPVME-ALVQHPGAFLKIIALrlceLLTMyiVTAFALNYSTQNLG-LPRELFLN 290
Cdd:cd17504 163 AAL-----------------------VPLIDlRLLRRRNVLLANITA----LLAG--FGMFMVFQLLPQLLqLPTPTGFG 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 291 IGLVVGGISCLTI--------PCFAWLADRFGRRRVYITGALIGTLSAwpFFMALEAQSVFWIVF--------FAIMLAN 354
Cdd:cd17504 214 LGITEAGLLLLPGalvmliagPLAGRLIARVGPRRVLLIGLVISAVGL--LLLALLHSSLWALVVallligigLGLAFAS 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 355 IAHDMVVCVQQPMFTELFGASY--RYSGAGVGYQVASVVGGGFTPFIAAALVTFSGGnWHSVAIYLLAGCLLSAATALLM 432
Cdd:cd17504 292 LPNIVVESVPPDRTGIATGMNTvlRTIGSAIGPAIAGAILTTYTVSITSGGVPTEGA-YVLAFLIGAALALAALLLSLLI 370
|
.
gi 692191013 433 K 433
Cdd:cd17504 371 P 371
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
61-215 |
4.55e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 45.26 E-value: 4.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 61 MGTLAAFATFGVGFLFRPLGGIIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFasigwwapVLLVTLRAIQGFAVG 140
Cdd:cd17325 232 LSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSF--------WLLLLLLALLGLGLG 303
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 692191013 141 GEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISQlttdeqflSWGWRIPFIFSIVLVVVALWI 215
Cdd:cd17325 304 LVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD--------AFGFATPFLAAAALLLLAAVL 370
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
82-214 |
5.79e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 44.86 E-value: 5.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 82 IIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFAsigwwapvLLVTLRAIQGFavggewGGAALLSVESA------P 155
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLA--------FLIAARALQGI------GAAAIMPASLAliaatfP 114
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 692191013 156 KNKK----AFYSSGVQVGYGVGLLLSTGLVSLisqlttdeqflsWGWRIPFIFSIVLVVVALW 214
Cdd:cd17321 115 GERRgralGLWGAVVGIGAALGPLLGGLLLEL------------FGWRWIFLINVPIGLVALL 165
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
90-362 |
6.25e-05 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 44.93 E-value: 6.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 90 RLGRKRML--MLTVWmmGIATALIGILPSFASigwwapvlLVTLRAIQGFAVGGEWGGAALLS------VESAPKnkKAF 161
Cdd:cd17327 67 RFPPSKWLsvFIVLW--GLLTLLTAAVKNFGG--------LIALRFFLGLFESGVFPGFILYLgmwykrEEQAKR--IAF 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 162 YSSGVQVGYGVGLLLSTGLVSLISQLTtdeqfLSwGWRIPFIF-----SIVLVVVALWIRNGMEESAEFERqqREKPVAK 236
Cdd:cd17327 135 FYAAAGLGSIFGGLLAYGVFKILGVGG-----LA-GWRWLFIIeglitIIIGLVIFFWLPDNPSKAWFLTE--EEKELAV 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 237 KRLPVMEALVQHPGAFLKIIALRLCELLT-MYIVTAFALN-----YSTQNLGLPRELF------LNIGLVVGGISCLTIP 304
Cdd:cd17327 207 ERLRANQTGKGDQKFKWKQIKEAFKDPRTwLLFLFFFCSQitnngISNFLPLILKSLGfyslqtNLLSVPIGALGAVSLL 286
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 692191013 305 CFAWLADRFGRRRVYITGALIGTLSAwpFFMALEAQSVFWIVFFAIMLANIAHDMVVC 362
Cdd:cd17327 287 IAALLSDRFKKRGLFAIFACVLALVG--SIILLAAPNPPGAYFAAYILGGGSYAGFPI 342
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
78-208 |
6.49e-05 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 44.59 E-value: 6.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 78 PLGGIIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFasigwwapVLLVTLRAIQGFAVGGEWGGAALLSVESAPKN 157
Cdd:cd17374 49 LVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTF--------PVYCVLRFLAGFAVSGISINTLILGTEWTTPR 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 692191013 158 KKAFYSSGVQVGYGVGLLLSTGLVSLISqlttDEQFLSWGWRIPFIFSIVL 208
Cdd:cd17374 121 HRALAITLTSCFFSIGQMLLAGLAYAIR----DWRLLQLVVSVPFFLFFLY 167
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
79-432 |
2.12e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 43.32 E-value: 2.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 79 LGGIIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFAsigwwapvLLVTLRAIQGFAVGGewGGAALLSV--ESAPK 156
Cdd:COG2807 68 LFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVA--------LLLAGTALIGAGIAV--GNVLLPGLikRWFPD 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 157 NKK---AFYSSGVQVGYGVGLLLSTGLVSlisqlttdeqflSWGWRIPFIFSIVLVVVAL--WIRngmeesaeFERQQRE 231
Cdd:COG2807 138 RVGlmtGLYTAAMGLGAALAAGLTVPLAA------------ALGWRGALAVWALLALLALllWLP--------LLRRRPA 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 232 KPVAKKRLPVMEALVQHPGAFLKIIALRLCeLLTMYIVTAFALNYSTQnLGLPRE---LFLNIGLVVGGISCLTIPcfaW 308
Cdd:COG2807 198 AAAAAPAAASLRSLWRSPLAWLLTLFFGLQ-SLLYYAVVAWLPPILRD-AGLSAAtagLLLSLFQLAGIPGSLLVP---L 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 309 LADRFGRRRVYITGALIGTLSAWPFFMALEAQS-VFWIVFFAIMLANIahdMVVCvqqPMFTELFGASYRYSGAGVGY-Q 386
Cdd:COG2807 273 LADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLpWLWAVLLGLGQGGL---FPLA---LTLIGLRARTPAEAAALSGMaQ 346
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 692191013 387 VASVVGGGFTPFIAAALVTFSGGnWHSVAIYLLAGCLLSAATALLM 432
Cdd:COG2807 347 SVGYLLAALGPLLVGALHDATGS-WTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
63-224 |
2.44e-04 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 43.33 E-value: 2.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 63 TLAAFATFG-VGFLFRPLGGIIFGHFGDRLGRKRMLMLTVWMMGIATALIgilpSFASIGWWapvlLVTLRAIQGFAVGG 141
Cdd:cd17358 39 TVAQFSWFGsLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLI----AFAKDVWM----LYLGRFLAGFGGGA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 142 EWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISqlttdeqflswgWRIPFIFSIVLVVVAL-------- 213
Cdd:cd17358 111 ASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLP------------WRTLALIGAIPPVVFLillffipe 178
|
170
....*....|....*
gi 692191013 214 ---W-IRNGMEESAE 224
Cdd:cd17358 179 sprWlAKKGREEEAE 193
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
267-437 |
4.08e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.41 E-value: 4.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 267 YIVTAFALNYSTQNLGLPRELFLNIGLVVGGISCLTIPCFAWLADRFGRRRVYITGALIGTLSAWPFFMAleaqSVFWIV 346
Cdd:cd06174 12 RGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA----PSFWLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 347 FFAIMLANIAHDMVVCVQQPMFTELFGASYRYSGAGVgYQVASVVGGGFTPFIAAALVTFSGGNWHSVAIYLLAGCLLSA 426
Cdd:cd06174 88 LLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGL-LQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAA 166
|
170
....*....|.
gi 692191013 427 ATALLMKETTH 437
Cdd:cd06174 167 ILLLLVVPDPP 177
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
79-407 |
4.87e-04 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 42.17 E-value: 4.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 79 LGGIIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFAsigwwapvLLVTLRAIQGFAVGGEWGGAALLSVESAPKNK 158
Cdd:cd17359 51 IGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFT--------IFIIARIIGGLAVGGASALVPMYIAEVAPAEI 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 159 KAFYSSGVQVGYGVGLLLSTGLVSLISQLTTDEQFLSWGWRIPFIFSIVLVVVALWIRNGMEESAEFERQQREKPVAkkr 238
Cdd:cd17359 123 RGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPESPRWLVSKGKPILI--- 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 239 LPVMEALVQHpgaFLKIIALrlcelltmyivtafaLNYST---QNLGLPRE--LFLNIGlvVGGISCLTIPCFAWLADRF 313
Cdd:cd17359 200 IGIGLAIFQQ---FVGINVI---------------FYYGPeifQNAGFSENaaLLQTIG--IGVVNVIFTIIAILLVDKV 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 314 GRRRVYITGALIGTLS----AWPFFMALEAQSVFWIVFFAIMLANIAHDMVVC-VQQPMFTELFGASYRYSGAGVgyqva 388
Cdd:cd17359 260 GRKPLLLIGSIGMAISllliGTAFYFAPGSQASGIVALVLILLFVAFFAMSWGpVTWVLLSEIFPNRIRGLAMGI----- 334
|
330
....*....|....*....
gi 692191013 389 svvgGGFTPFIAAALVTFS 407
Cdd:cd17359 335 ----AVFFLWIANFLVSLT 349
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
32-332 |
7.06e-04 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 41.83 E-value: 7.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 32 VVDWYDFLLYGITAALVFnrEFFPQISPAMGTLAAFA-------TFGVGFLFRPLGGIIFGHFGDRLGRKRMLMLTVWMM 104
Cdd:PRK09874 17 TVAWLGCFLTGAAFSLVM--PFLPLYVEQLGVTGHSAlnmwsglVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGM 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 105 GIATALIGILPSFasigwWApvlLVTLRAIQGFaVGGEWGGAALLSVESAPKNKKafyssgvqvGYGVGlLLSTGLVS-- 182
Cdd:PRK09874 95 GIVMVLMGLAQNI-----WQ---FLILRALLGL-LGGFVPNANALIATQVPRNKS---------GWALG-TLSTGGVSga 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 183 LISQLTTDEQFLSWGWRIPFIFS-----IVLVVVALWIRNGMEESAEFERQQREKPVAKKRLPVMEALVQHPGAFLKIIA 257
Cdd:PRK09874 156 LLGPLAGGLLADSYGLRPVFFITasvlfLCFLVTLFCIRENFQPVSKKEMLHMREVVTSLKNPKLVLSLFVTTLIIQVAT 235
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 692191013 258 LRLCELLTMYiVTAFALNYStqNLGLPRELflnIGLVVGGISCLTIPCFAWLADRFGRRRVYITGALIGTLSAWP 332
Cdd:PRK09874 236 GSIAPILTLY-VRELAGNVS--NIAFISGM---IASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIP 304
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
264-424 |
9.46e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 41.46 E-value: 9.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 264 LTMYIVTAFALNYSTQNLGlPRELFLNIGLVVGGISCLTIPCFAWLADRFGRRRVYITGALIGTLSawpFFMALEAQSVF 343
Cdd:cd06179 11 LFGVTLPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVG---SIVAGTAKSVN 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 344 WIVFFAIMLAnIAHDMVVCVqQPMFTELFGASYRYSGAGVGYqVASVVGGGFTPFIAAALVTFSGGNWHSV-----AIYL 418
Cdd:cd06179 87 MLIGGQALIG-IGAGTQGLG-AAVASELVPNKYRGLVQGVVN-LVASPGSALGPLIAGALVEANAAGWRWIfyinaIFNA 163
|
....*.
gi 692191013 419 LAGCLL 424
Cdd:cd06179 164 LALILL 169
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
68-215 |
1.06e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 41.09 E-value: 1.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 68 ATFGVGFLFrplGGIIFGHFGDRLGRKRMLMLtvwmmGIATALIGILPSFASIGWWAPVLLVTLRAIQGFAVGGEWGGAA 147
Cdd:cd17357 56 SIFFIGGAI---GSFISAFLANRFGRKNGLLI-----SNALLVVSSLLMFLSKSAKSPELLIFGRFLVGIACGLSTGFVP 127
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 692191013 148 LLSVESAPKNKKAFYSSGVQVGYGVGLLLsTGLVSLISQLTTdEQFLSWGWRIPFIFSIVLVVVALWI 215
Cdd:cd17357 128 MYLQEISPSELRGALGSLTQIGVTLGILL-GQVFGLPSVLGT-ETLWPYLLFFPGIPALLQLAALPFF 193
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
80-215 |
1.27e-03 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 40.98 E-value: 1.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 80 GGIIFGHFGDRLGRKRMLMLTVwmmgIATALIGILPSFASIGWWapvlLVTLRAIQGFAVGGEWGGAAlLSVESAPKNKK 159
Cdd:cd17372 50 GSYLWGIVSDKYGRRKGLIISA----LWTFYAGFLSAFAPNYMW----LIILRCLVGLGLGGGPQLAS-WYLEFLPAKSR 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 692191013 160 AFYSSGVQVGYGVGLLLSTGLVSLISQLttdeqfLSWGWRIPF--IFSIVLVVVALWI 215
Cdd:cd17372 121 GTWMVLFSVFWTVGTIFEASLAWLVMPR------LGWRWLLAFssVPSSLLLVFYRWT 172
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
79-211 |
2.20e-03 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 40.03 E-value: 2.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 79 LGGIIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFAsigwwapvLLVTLRAIQGFAVGGEWGGAALLSVESAPKN- 157
Cdd:cd17362 54 LGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYP--------VLLVGRLIYGVGIGLAMHAAPVYIAETSPSHi 125
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 692191013 158 -------KKAFYSSGVQVGYGVGLLLSTglvslisqlttdeqfLSWGWRIPFIFSIVLVVV 211
Cdd:cd17362 126 rgllvslKELFIVLGILLGYVSGYAFAD---------------VVGGWRYMYGLAAPPALL 171
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
79-186 |
2.99e-03 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 39.71 E-value: 2.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 79 LGGIIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFASigwwapvlLVTLRAIQGFAVGGEWGGAALLSVESAPKNK 158
Cdd:cd17446 48 VGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPI--------YCVFRFLTGMALSGIVLNSVSLNVEWMPTRV 119
|
90 100
....*....|....*....|....*...
gi 692191013 159 KAFYSSGVQVGYGVGLLLSTGLVSLISQ 186
Cdd:cd17446 120 RAVVGTLLGYCYTLGQLILAGVAYAIRD 147
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
79-432 |
3.07e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 39.48 E-value: 3.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 79 LGGIIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFAsigwwapvLLVTLRAIQGFAVGGEWGGAALLSVESAPKNK 158
Cdd:cd17320 49 LGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIE--------QLLIARFLQGLGAAAGSVVARAIVRDLYSGAE 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 159 KAFYSSGVQVGYGVGLLLSTGLVSLISQLttdeqflsWGWRIPFIF-SIVLVVVALWIRNGMEESAefeRQQREKPVAKK 237
Cdd:cd17320 121 LAKIFSLLMMILAIAPALAPLLGGLLLLF--------FGWRAIFVFlALLGLLLLLLVLLFLPETL---PEEKRKPLLSS 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 238 RLPVMEALVQHPGAFLKIIALRLCELLTMYIVTAFALNYSTQnLGLPRELFLNIGLVVGGISCLTIPCFAWLADRFGRRR 317
Cdd:cd17320 190 LLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQ-LGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRR 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 318 VYITGALIGTLSA-WPFFMALEAQSVFWIVFFAIMLANIAHDMVVCVQQPMFTELFGasyrySGAGVgyqvASVVGGGFT 396
Cdd:cd17320 269 LLRLGLLLLLAAAlVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFP-----HVAGT----ASALLGFLQ 339
|
330 340 350
....*....|....*....|....*....|....*.
gi 692191013 397 PFIAAALVTFSGGNWHSVAIYLLAGCLLSAATALLM 432
Cdd:cd17320 340 FLIGALAGALVGLLPNGTALPMGLLILVLGLLALLL 375
|
|
| MFS_NLS1_MFSD2A |
cd17451 |
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of ... |
203-353 |
3.13e-03 |
|
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of transporters; Sodium-dependent lysophosphatidylcholine (LPC) symporter 1 (NLS1) is also called major facilitator superfamily domain-containing protein 2A (MFSD2A). NLS1/MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. It also transports the essential omega-3 fatty acid docosahexaenoic acid (DHA), which is essential for normal brain growth and cognitive function, in the form of LPC into the brain across the blood-brain barrier. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. NLS1/MFSD2A belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341009 Cd Length: 419 Bit Score: 39.80 E-value: 3.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 203 IFSIVLVVVALWIRNGMEESAEFERQQREKPVAKKRlpvMEALVQHPGAFLK-IIALRLCELLTMYIVTAFALnYSTQNL 281
Cdd:cd17451 171 VICAIYVLCAIILFLGVREQREPCELKSQKPVSFFK---GLKLVMSHGPYIKlITGFLFTSLAFMLLEGNFAL-FCTYTL 246
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 692191013 282 GLPRElFLNIGLVVGGISCLTIPCFAWLADRFGRRrvyiTGALIGTLSAWPFFMALEAQSVFWIVFFAIMLA 353
Cdd:cd17451 247 GFRND-FQNILLVIMLSATLTIPFWQWFLTRFGKK----TAVYIGISSAVPFLILVVLVESNLIVTYVVSVA 313
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
61-213 |
4.17e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.06 E-value: 4.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 61 MGTLAAFATFGVGFLFRPLGGIIFGHFGDRLGRKRMLmltvwmmgIATALIGILPSFASIGWWAPVLLVTLRAIQGFAVG 140
Cdd:cd17370 231 LSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLL--------ILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMG 302
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 692191013 141 GEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISQLttdeqflsWGWRIPFIFSIVLVVVAL 213
Cdd:cd17370 303 AQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDL--------ISPSAAFLFSAVLALIAL 367
|
|
| MFS_SLC22A7_OAT2 |
cd17447 |
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ... |
79-214 |
8.01e-03 |
|
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341005 [Multi-domain] Cd Length: 341 Bit Score: 38.17 E-value: 8.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 79 LGGIIFGHFGDRLGRKRMLMLTVwmmgIATALIGILPSFASigwwAPVLLVTLRAIQGFAVGGEWGGAALLSVESAPKNK 158
Cdd:cd17447 50 MGAVAFGYLSDRFGRKRMLLVAY----VLSLVFGLASAFSV----SYVMFAITRTLTGFALTGFSIISMVLCVEWVDIEH 121
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 692191013 159 KAFYSSGVQVGYGVGLLlstgLVSLISQLTTDeqflsWGWRIPFIFS-IVLVVVALW 214
Cdd:cd17447 122 RTVAGVLISLFWTVGNM----LLALVAYLIRD-----WRWLILAVTLpCAPGIITWW 169
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
58-350 |
9.97e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 38.21 E-value: 9.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 58 SPAMGTLAAFATFGVGFLFRPLGGIIFGHFGDRLG-RKRMLMLTVWMMGIATALigiLPSFASIGWWAPVLLVTLRAIqG 136
Cdd:COG2270 46 DPAAATALWGYALAIAGLLVALLAPVLGAIADRSGrKKPFLAFFTLLGVLATAA---LFFVAPGGLWLGLLLFVLANI-G 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 137 FavggeWGG----AALLSVESAPKNKKAFYSSGVQVGY---GVGLLLSTGLVSLISQLTTDEQFLswGWRIPFIFS-IVL 208
Cdd:COG2270 122 F-----EGSlvfyNAFLPDIATPEEIGRVSGLGWALGYlggVLLLLINLALFLKPEAFGLPDAGE--AVRISFLLTaLWW 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692191013 209 VVVALWIRNGMEESAEFERQQREKPVAK--KRL-PVMEALVQHPGAFLKIIAlRLCELLTMYIVTAFALNYSTQNLGLPR 285
Cdd:COG2270 195 LLFALPLFLFLPERPRPGPAPPRGAVRAgfRELrRTLRELRRYRDLLRFLLA-YFFYRDGVQTVIAFAGIYAAGVLGFST 273
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 692191013 286 ELFLNIGL---VVGGISCLtipCFAWLADRFGRRRVYITGALIGTLS-AWPFFMalEAQSVFWIVFFAI 350
Cdd:COG2270 274 TELIVFGLlvqIVAALGAL---LFGRLDDRIGPKRVILVSLVIWIVVcLAAYFL--TTALAFWILGLLI 337
|
|
| |
