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Conserved domains on  [gi|693055471|ref|WP_032223509|]
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glycosyltransferase family 2 protein [Escherichia coli]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 10135931)

glycosyltransferase family 2 protein catalyzes the transfer of saccharide moieties from a donor to an acceptor to form glycosidic bonds

CATH:  3.90.550.10
CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
PubMed:  10508766|12200473|9445404|12691742|10521532
SCOP:  3000077

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT_2_like_d cd04196
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 10-223 9.38e-82

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


:

Pssm-ID: 133039 [Multi-domain]  Cd Length: 214  Bit Score: 246.39  E-value: 9.38e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471  10 AIVLASYNGQLYIKEQVLSILNQSYQYIKLYCSDDGSTDGTIDYLKEYQKNN---IVIAKNDGKKGPAYNFINGLKLVGD 86
Cdd:cd04196    1 AVLMATYNGEKYLREQLDSILAQTYKNDELIISDDGSTDGTVEIIKEYIDKDpfiIILIRNGKNLGVARNFESLLQAADG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471  87 EkYIIFSDQDDVWMPEKVSTLksyADKLLNNDKPGAIYCDALIVDHSLTQLGKRMYGEHHICPTKISELLYLNGGVQGAS 166
Cdd:cd04196   81 D-YVFFCDQDDIWLPDKLERL---LKAFLKDDKPLLVYSDLELVDENGNPIGESFFEYQKIKPGTSFNNLLFQNVVTGCT 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 693055471 167 MLINRKMMDEMLSYNKY-IYMHDQLATYLAVVYKNIYYINIPLMLYRQHSKNVIGVNT 223
Cdd:cd04196  157 MAFNRELLELALPFPDAdVIMHDWWLALLASAFGKVVFLDEPLILYRQHGNNVVGANK 214
 
Name Accession Description Interval E-value
GT_2_like_d cd04196
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 10-223 9.38e-82

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133039 [Multi-domain]  Cd Length: 214  Bit Score: 246.39  E-value: 9.38e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471  10 AIVLASYNGQLYIKEQVLSILNQSYQYIKLYCSDDGSTDGTIDYLKEYQKNN---IVIAKNDGKKGPAYNFINGLKLVGD 86
Cdd:cd04196    1 AVLMATYNGEKYLREQLDSILAQTYKNDELIISDDGSTDGTVEIIKEYIDKDpfiIILIRNGKNLGVARNFESLLQAADG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471  87 EkYIIFSDQDDVWMPEKVSTLksyADKLLNNDKPGAIYCDALIVDHSLTQLGKRMYGEHHICPTKISELLYLNGGVQGAS 166
Cdd:cd04196   81 D-YVFFCDQDDIWLPDKLERL---LKAFLKDDKPLLVYSDLELVDENGNPIGESFFEYQKIKPGTSFNNLLFQNVVTGCT 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 693055471 167 MLINRKMMDEMLSYNKY-IYMHDQLATYLAVVYKNIYYINIPLMLYRQHSKNVIGVNT 223
Cdd:cd04196  157 MAFNRELLELALPFPDAdVIMHDWWLALLASAFGKVVFLDEPLILYRQHGNNVVGANK 214
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 8-218 4.53e-21

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 88.99  E-value: 4.53e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471   8 MVAIVLASYNGQLYIKEQVLSILNQSYQYIKLYCSDDGSTDGTIDYLKEYQKN--NIVIAKNDGKKGPAYNFINGLKLV- 84
Cdd:COG0463    3 LVSVVIPTYNEEEYLEEALESLLAQTYPDFEIIVVDDGSTDGTAEILRELAAKdpRIRVIRLERNRGKGAARNAGLAAAr 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471  85 GDekYIIFSDQDDVWMPEKVSTLKsyadKLLNNDKPGAIYCDALIVDhsltqlGKRMYGEHHICPTKISELLYLNGGVQG 164
Cdd:COG0463   83 GD--YIAFLDADDQLDPEKLEELV----AALEEGPADLVYGSRLIRE------GESDLRRLGSRLFNLVRLLTNLPDSTS 150

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 693055471 165 ASMLINRKMMDEmLSYNKYiYMHDQLATYLAVVYKNIYYINIplmLYRQHSKNV 218
Cdd:COG0463  151 GFRLFRREVLEE-LGFDEG-FLEDTELLRALRHGFRIAEVPV---RYRAGESKL 199
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 11-176 1.58e-17

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 78.21  E-value: 1.58e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471   11 IVLASYNGQLYIKEQVLSILNQSYQYIKLYCSDDGSTDGTIDYLKEYQKN--NIVIAKNDGKKGPAYNFINGLKLVGDEk 88
Cdd:pfam00535   2 VIIPTYNEEKYLLETLESLLNQTYPNFEIIVVDDGSTDGTVEIAEEYAKKdpRVRVIRLPENRGKAGARNAGLRAATGD- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471   89 YIIFSDQDDVWMPEKVSTLksyADKLLNNDKPGAIYCDALIVDHS-LTQLGKRMYGEHHICPTKISELLYLNGGVQGASM 167
Cdd:pfam00535  81 YIAFLDADDEVPPDWLEKL---VEALEEDGADVVVGSRYVIFGETgEYRRASRITLSRLPFFLGLRLLGLNLPFLIGGFA 157


                  ....*....
gi 693055471  168 LINRKMMDE 176
Cdd:pfam00535 158 LYRREALEE 166
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 8-118 9.56e-06

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 46.58  E-value: 9.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471   8 MVAIVLASYNGQLYIKEQVLSILNQSYQYIKLYCSDDGSTDGTIDYLKEYQKN--NI-VIAKNDGKKGPAYNfiNGLKlV 84
Cdd:PRK10073   7 KLSIIIPLYNAGKDFRAFMESLIAQTWTALEIIIVNDGSTDNSVEIAKHYAENypHVrLLHQANAGVSVARN--TGLA-V 83

                         90       100       110
                 ....*....|....*....|....*....|....
gi 693055471  85 GDEKYIIFSDQDDVWMPEKVSTLKSYAdklLNND 118
Cdd:PRK10073  84 ATGKYVAFPDADDVVYPTMYETLMTMA---LEDD 114
 
Name Accession Description Interval E-value
GT_2_like_d cd04196
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 10-223 9.38e-82

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133039 [Multi-domain]  Cd Length: 214  Bit Score: 246.39  E-value: 9.38e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471  10 AIVLASYNGQLYIKEQVLSILNQSYQYIKLYCSDDGSTDGTIDYLKEYQKNN---IVIAKNDGKKGPAYNFINGLKLVGD 86
Cdd:cd04196    1 AVLMATYNGEKYLREQLDSILAQTYKNDELIISDDGSTDGTVEIIKEYIDKDpfiIILIRNGKNLGVARNFESLLQAADG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471  87 EkYIIFSDQDDVWMPEKVSTLksyADKLLNNDKPGAIYCDALIVDHSLTQLGKRMYGEHHICPTKISELLYLNGGVQGAS 166
Cdd:cd04196   81 D-YVFFCDQDDIWLPDKLERL---LKAFLKDDKPLLVYSDLELVDENGNPIGESFFEYQKIKPGTSFNNLLFQNVVTGCT 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 693055471 167 MLINRKMMDEMLSYNKY-IYMHDQLATYLAVVYKNIYYINIPLMLYRQHSKNVIGVNT 223
Cdd:cd04196  157 MAFNRELLELALPFPDAdVIMHDWWLALLASAFGKVVFLDEPLILYRQHGNNVVGANK 214
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 8-218 4.53e-21

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 88.99  E-value: 4.53e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471   8 MVAIVLASYNGQLYIKEQVLSILNQSYQYIKLYCSDDGSTDGTIDYLKEYQKN--NIVIAKNDGKKGPAYNFINGLKLV- 84
Cdd:COG0463    3 LVSVVIPTYNEEEYLEEALESLLAQTYPDFEIIVVDDGSTDGTAEILRELAAKdpRIRVIRLERNRGKGAARNAGLAAAr 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471  85 GDekYIIFSDQDDVWMPEKVSTLKsyadKLLNNDKPGAIYCDALIVDhsltqlGKRMYGEHHICPTKISELLYLNGGVQG 164
Cdd:COG0463   83 GD--YIAFLDADDQLDPEKLEELV----AALEEGPADLVYGSRLIRE------GESDLRRLGSRLFNLVRLLTNLPDSTS 150

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 693055471 165 ASMLINRKMMDEmLSYNKYiYMHDQLATYLAVVYKNIYYINIplmLYRQHSKNV 218
Cdd:COG0463  151 GFRLFRREVLEE-LGFDEG-FLEDTELLRALRHGFRIAEVPV---RYRAGESKL 199
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 11-130 1.36e-18

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 81.01  E-value: 1.36e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471  11 IVLASYNGQLYIKEQVLSILNQSYQYIKLYCSDDGSTDGTIDYLKEYQKNNIVIAK--NDGKKGPAYNFINGLKLVGDEk 88
Cdd:cd00761    1 VIIPAYNEEPYLERCLESLLAQTYPNFEVIVVDDGSTDGTLEILEEYAKKDPRVIRviNEENQGLAAARNAGLKAARGE- 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 693055471  89 YIIFSDQDDVWMPEKVSTLKSYadkLLNNDKPGAIYCDALIV 130
Cdd:cd00761   80 YILFLDADDLLLPDWLERLVAE---LLADPEADAVGGPGNLL 118
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 11-176 1.58e-17

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 78.21  E-value: 1.58e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471   11 IVLASYNGQLYIKEQVLSILNQSYQYIKLYCSDDGSTDGTIDYLKEYQKN--NIVIAKNDGKKGPAYNFINGLKLVGDEk 88
Cdd:pfam00535   2 VIIPTYNEEKYLLETLESLLNQTYPNFEIIVVDDGSTDGTVEIAEEYAKKdpRVRVIRLPENRGKAGARNAGLRAATGD- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471   89 YIIFSDQDDVWMPEKVSTLksyADKLLNNDKPGAIYCDALIVDHS-LTQLGKRMYGEHHICPTKISELLYLNGGVQGASM 167
Cdd:pfam00535  81 YIAFLDADDEVPPDWLEKL---VEALEEDGADVVVGSRYVIFGETgEYRRASRITLSRLPFFLGLRLLGLNLPFLIGGFA 157


                  ....*....
gi 693055471  168 LINRKMMDE 176
Cdd:pfam00535 158 LYRREALEE 166
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
8-111 1.63e-16

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 76.57  E-value: 1.63e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471   8 MVAIVLASYNGQLYIKEQVLSILNQSYQYIKLYCSDDGSTDGTIDYLKEYQKNNIVIAKNDGKKGPAYNFiN-GLKLVGD 86
Cdd:COG1216    4 KVSVVIPTYNRPELLRRCLESLLAQTYPPFEVIVVDNGSTDGTAELLAALAFPRVRVIRNPENLGFAAAR-NlGLRAAGG 82

                         90       100
                 ....*....|....*....|....*
gi 693055471  87 EkYIIFSDQDDVWMPEKVSTLKSYA 111
Cdd:COG1216   83 D-YLLFLDDDTVVEPDWLERLLAAA 106
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 11-214 8.04e-14

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 69.11  E-value: 8.04e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471  11 IVLASYNGQLYIKEQVLSILNQSYQYIKLYCSDDGSTDGTIDYLKEYQKNNI-VIAKNDgkKGPaYNFIN-GLKLVGDEk 88
Cdd:cd06433    2 IITPTYNQAETLEETIDSVLSQTYPNIEYIVIDGGSTDGTVDIIKKYEDKITyWISEPD--KGI-YDAMNkGIALATGD- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471  89 YIIFSDQDDVWMPEkvsTLKSYADKLLNNDKPGAIYCDALIVDHSltqlGKRMYgeHHICPTKISELLYLNGGVQGASML 168
Cdd:cd06433   78 IIGFLNSDDTLLPG---ALLAVVAAFAEHPEVDVVYGDVLLVDEN----GRVIG--RRRPPPFLDKFLLYGMPICHQATF 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 693055471 169 INRKMMDEMLSYN-KYIYMHDQ-LATYLAVVYKNIYYINIPLMLYRQH 214
Cdd:cd06433  149 FRRSLFEKYGGFDeSYRIAADYdLLLRLLLAGKIFKYLPEVLAAFRLG 196
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 9-101 9.08e-11

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 61.68  E-value: 9.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471   9 VAIVLASYNGQLYIKEQVLSILNQSYQYIKL--YCSDDGSTDGTIDYLKEYQK--NNIVIAKNDGKKGPAYNFINGLKLV 84
Cdd:COG1215   31 VSVIIPAYNEEAVIEETLRSLLAQDYPKEKLevIVVDDGSTDETAEIARELAAeyPRVRVIERPENGGKAAALNAGLKAA 110

                         90
                 ....*....|....*...
gi 693055471  85 -GDekYIIFSDQDDVWMP 101
Cdd:COG1215  111 rGD--IVVFLDADTVLDP 126
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 9-142 1.51e-09

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 57.59  E-value: 1.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471   9 VAIVLASYNGQLYIKEQVLSILNQSY--QYIKLYCSDDGSTDGTIDYLKEYQKNNIVIAKNDGKKGPAyNFIN-GLKLVG 85
Cdd:cd06439   31 VTIIIPAYNEEAVIEAKLENLLALDYprDRLEIIVVSDGSTDGTAEIAREYADKGVKLLRFPERRGKA-AALNrALALAT 109

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 693055471  86 DEkYIIFSDQDDVWMPEKVSTLksyaDKLLNNDKPGAIYCDALIVDHSLTQLGKRMY 142
Cdd:cd06439  110 GE-IVVFTDANALLDPDALRLL----VRHFADPSVGAVSGELVIVDGGGSGSGEGLY 161
Glyco_tranf_2_3 pfam13641
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 8-176 6.38e-09

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433372 [Multi-domain]  Cd Length: 230  Bit Score: 55.45  E-value: 6.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471    8 MVAIVLASYNGQLYIKEQVLSILNQSYQYIKLYCSDDGSTDGTIDYLKE----YQKNNI--VIAKNDGKKGPAYNFINGL 81
Cdd:pfam13641   3 DVSVVVPAFNEDSVLGRVLEAILAQPYPPVEVVVVVNPSDAETLDVAEEiaarFPDVRLrvIRNARLLGPTGKSRGLNHG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471   82 KLVGDEKYIIFSDQDDVWMPEkvsTLKSYAdKLLNNDKPGAIYC--DALIVDHSLTQLGKRMYGEHHI-CP--TKISELL 156
Cdd:pfam13641  83 FRAVKSDLVVLHDDDSVLHPG---TLKKYV-QYFDSPKVGAVGTpvFSLNRSTMLSALGALEFALRHLrMMslRLALGVL 158

                         170       180
                  ....*....|....*....|
gi 693055471  157 YLNggvqGASMLINRKMMDE 176
Cdd:pfam13641 159 PLS----GAGSAIRREVLKE 174
GT2_RfbC_Mx_like cd04184
Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene ...
 8-126 1.16e-08

Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene encodes a predicted protein of 1,276 amino acids, which is required for O-antigen biosynthesis in Myxococcus xanthus. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133027 [Multi-domain]  Cd Length: 202  Bit Score: 54.13  E-value: 1.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471   8 MVAIVLASYNG-QLYIKEQVLSILNQSYQYIKLYCSDDGSTD-GTIDYLKEYQKNN----IVIAKNDGkkGPAYNFINGL 81
Cdd:cd04184    2 LISIVMPVYNTpEKYLREAIESVRAQTYPNWELCIADDASTDpEVKRVLKKYAAQDprikVVFREENG--GISAATNSAL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 693055471  82 KL-VGDekYIIFSDQDDVWMPEkvsTLKSYADKLLNNDKPGAIYCD 126
Cdd:cd04184   80 ELaTGE--FVALLDHDDELAPH---ALYEVVKALNEHPDADLIYSD 120
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 9-74 2.31e-06

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 48.00  E-value: 2.31e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471   9 VAIVLASYNGQLYIKEQVLSILNQSYQY--IKLYCSDDGSTDGTIDYLKEYQK--NNIVIAKNDGKKGPA 74
Cdd:cd02525    2 VSIIIPVRNEEKYIEELLESLLNQSYPKdlIEIIVVDGGSTDGTREIVQEYAAkdPRIRLIDNPKRIQSA 71
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 11-123 3.77e-06

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 46.40  E-value: 3.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471  11 IVLASYNGQLYIKEQVLSILNQSYQYIKLYCSDDGSTDGTIDYLKEYQKNNIVIaKNDGKKGPAYNFINGLKLVGDEkYI 90
Cdd:cd04186    1 IIIVNYNSLEYLKACLDSLLAQTYPDFEVIVVDNASTDGSVELLRELFPEVRLI-RNGENLGFGAGNNQGIREAKGD-YV 78

                         90       100       110
                 ....*....|....*....|....*....|...
gi 693055471  91 IFSDqDDVWMPEkvSTLKSYADKLLNNDKPGAI 123
Cdd:cd04186   79 LLLN-PDTVVEP--GALLELLDAAEQDPDVGIV 108
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 8-118 9.56e-06

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 46.58  E-value: 9.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471   8 MVAIVLASYNGQLYIKEQVLSILNQSYQYIKLYCSDDGSTDGTIDYLKEYQKN--NI-VIAKNDGKKGPAYNfiNGLKlV 84
Cdd:PRK10073   7 KLSIIIPLYNAGKDFRAFMESLIAQTWTALEIIIVNDGSTDNSVEIAKHYAENypHVrLLHQANAGVSVARN--TGLA-V 83

                         90       100       110
                 ....*....|....*....|....*....|....
gi 693055471  85 GDEKYIIFSDQDDVWMPEKVSTLKSYAdklLNND 118
Cdd:PRK10073  84 ATGKYVAFPDADDVVYPTMYETLMTMA---LEDD 114
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 11-97 7.75e-05

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 42.56  E-value: 7.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471  11 IVLASYNGQLYIKE---QVLSILNQSYQYiKLYCSDDGSTDGTIDYLKEYQKN--NIVIAKNDGKKGPAYNFINGLKLV- 84
Cdd:cd04179    1 VVIPAYNEEENIPElveRLLAVLEEGYDY-EIIVVDDGSTDGTAEIARELAARvpRVRVIRLSRNFGKGAAVRAGFKAAr 79

                         90
                 ....*....|....*.
gi 693055471  85 GDekYIIFSD---QDD 97
Cdd:cd04179   80 GD--IVVTMDadlQHP 93
beta3GnTL1_like cd06913
Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of ...
 11-105 2.51e-04

Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of poly-N-acetyllactosamine ; This family includes human Beta3GnTL1 and related eukaryotic proteins. Human Beta3GnTL1 is a putative beta-1,3-N-acetylglucosaminyltransferase. Beta3GnTL1 is expressed at various levels in most of tissues examined. Beta 1, 3-N-acetylglucosaminyltransferase has been found to be essential for the formation of poly-N-acetyllactosamine. Poly-N-acetyllactosamine is a unique carbohydrate composed of N-acetyllactosamine repeats. It is often an important part of cell-type-specific oligosaccharide structures and some functional oligosaccharides. It has been shown that the structure and biosynthesis of poly-N-acetyllactosamine display a dramatic change during development and oncogenesis. Several members of beta-1, 3-N-acetylglucosaminyltransferase have been identified.


Pssm-ID: 133063 [Multi-domain]  Cd Length: 219  Bit Score: 41.67  E-value: 2.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471  11 IVLASYNGQLYIKEQVLSILNQSY-QYIKLYCSDDGSTDGTIDYLKEYQK-----NNIVIAKN---DGKKGPAYNfINGL 81
Cdd:cd06913    1 IILPVHNGEQWLDECLESVLQQDFeGTLELSVFNDASTDKSAEIIEKWRKkledsGVIVLVGShnsPSPKGVGYA-KNQA 79

                         90       100
                 ....*....|....*....|....
gi 693055471  82 KLVGDEKYIIFSDQDDVWMPEKVS 105
Cdd:cd06913   80 IAQSSGRYLCFLDSDDVMMPQRIR 103
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 11-123 4.50e-04

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 40.29  E-value: 4.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471  11 IVLASYNGQLYIKEQVLSILNQSYQYIKLYCSDDGSTDGTIDYLKEY---QKNNIVIAKNDGKKGPAYNFINGLKLVgDE 87
Cdd:cd06423    1 IIVPAYNEEAVIERTIESLLALDYPKLEVIVVDDGSTDDTLEILEELaalYIRRVLVVRDKENGGKAGALNAGLRHA-KG 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 693055471  88 KYIIFSDQDDVwmPEKvSTLKSYADKLLNNDKPGAI 123
Cdd:cd06423   80 DIVVVLDADTI--LEP-DALKRLVVPFFADPKVGAV 112
GT_2_like_b cd04185
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 10-98 8.19e-04

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133028 [Multi-domain]  Cd Length: 202  Bit Score: 39.93  E-value: 8.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471  10 AIVLaSYNGQLYIKEQVLSILNQSYQYIKLYCSDDGSTDGTIDYLKEyQKN--NIVIAKNDGKKGPAYNFINGLKLVGDE 87
Cdd:cd04185    1 AVVV-TYNRLDLLKECLDALLAQTRPPDHIIVIDNASTDGTAEWLTS-LGDldNIVYLRLPENLGGAGGFYEGVRRAYEL 78

                         90
                 ....*....|...
gi 693055471  88 --KYIIFSDqDDV 98
Cdd:cd04185   79 gyDWIWLMD-DDA 90
PRK10018 PRK10018
colanic acid biosynthesis glycosyltransferase WcaA;
8-114 6.60e-03

colanic acid biosynthesis glycosyltransferase WcaA;


Pssm-ID: 182197 [Multi-domain]  Cd Length: 279  Bit Score: 37.66  E-value: 6.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693055471   8 MVAIVLASYNGQLYIKEQVLSILNQSYQYIKLYCSDDGSTDGTidylkeyQKNNIVIAKNDGKKGPAYNFIN-GLKLVGD 86
Cdd:PRK10018   6 LISIYMPTWNRQQLAIRAIKSVLRQDYSNWEMIIVDDCSTSWE-------QLQQYVTALNDPRITYIHNDINsGACAVRN 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 693055471  87 E-------KYIIFSDQDDVWMPEKVSTLKSYADKL 114
Cdd:PRK10018  79 QaimlaqgEYITGIDDDDEWTPNRLSVFLAHKQQL 113
DPM1_like_bac cd04187
Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes ...
 11-70 6.76e-03

Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133030 [Multi-domain]  Cd Length: 181  Bit Score: 37.07  E-value: 6.76e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 693055471  11 IVLASYNGQLYIKE------QVLSILNQSYQYIklyCSDDGSTDGTIDYLKEYQKNN-----IVIAKNDGK 70
Cdd:cd04187    1 IVVPVYNEEENLPElyerlkAVLESLGYDYEII---FVDDGSTDRTLEILRELAARDprvkvIRLSRNFGQ 68
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 43-96 9.74e-03

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 36.78  E-value: 9.74e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 693055471  43 DDGSTDGTIDYLKEYQKNN---IVIAKNDGKKGPAYNFINGLkLVGDEKYIIFSDQD 96
Cdd:cd04188   37 DDGSKDGTAEVARKLARKNpalIRVLTLPKNRGKGGAVRAGM-LAARGDYILFADAD 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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