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Conserved domains on  [gi|694061918|ref|WP_032408579|]
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MULTISPECIES: BRO family protein [Klebsiella]

Protein Classification

Bro-N domain-containing protein( domain architecture ID 11466490)

Bro-N domain-containing protein may bind DNA to influence host DNA replication and/or transcription; may function as an antirepressor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3617 COG3617
Prophage antirepressor [Mobilome: prophages, transposons];
1-108 1.68e-44

Prophage antirepressor [Mobilome: prophages, transposons];


:

Pssm-ID: 442835  Cd Length: 106  Bit Score: 144.27  E-value: 1.68e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694061918   1 MNTKPSVFSFESsNQIRAVIINGEPWFVAADVIKALQLTNPTMSMKALDEDERSKLNL----GRQGTaNIISESGLYTLI 76
Cdd:COG3617    1 MNNLITVFNFEG-HEVRTVEIDGEPWFVAKDVARALGYSNPSDALKHLDDDEKTKLELdtpgGPQEM-LFISESGLYRLI 78

                         90       100       110
                 ....*....|....*....|....*....|..
gi 694061918  77 LRCRDAVTPgtipyRFRKWVTSEVLPQIRKTG 108
Cdd:COG3617   79 LRSRKPEAK-----RFKRWVTDEVLPSIRKTG 105
 
Name Accession Description Interval E-value
COG3617 COG3617
Prophage antirepressor [Mobilome: prophages, transposons];
1-108 1.68e-44

Prophage antirepressor [Mobilome: prophages, transposons];


Pssm-ID: 442835  Cd Length: 106  Bit Score: 144.27  E-value: 1.68e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694061918   1 MNTKPSVFSFESsNQIRAVIINGEPWFVAADVIKALQLTNPTMSMKALDEDERSKLNL----GRQGTaNIISESGLYTLI 76
Cdd:COG3617    1 MNNLITVFNFEG-HEVRTVEIDGEPWFVAKDVARALGYSNPSDALKHLDDDEKTKLELdtpgGPQEM-LFISESGLYRLI 78

                         90       100       110
                 ....*....|....*....|....*....|..
gi 694061918  77 LRCRDAVTPgtipyRFRKWVTSEVLPQIRKTG 108
Cdd:COG3617   79 LRSRKPEAK-----RFKRWVTDEVLPSIRKTG 105
Bro-N smart01040
BRO family, N-terminal domain; This family includes the N-terminus of baculovirus BRO and ALI ...
 15-102 1.19e-32

BRO family, N-terminal domain; This family includes the N-terminus of baculovirus BRO and ALI motif proteins. The function of BRO proteins is unknown. It has been suggested that BRO-A and BRO-C are DNA binding proteins that influence host DNA replication and/or transcription. This Pfam domain does not include the characteristic invariant alanine, leucine, isoleucine motif of the ALI proteins.


Pssm-ID: 214989  Cd Length: 89  Bit Score: 113.44  E-value: 1.19e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694061918    15 QIRAVIINGEPWFVAADVIKALQLTNPTMSMKALDEDERSKLN------LGRQGTANIISESGLYTLILRCRDAVtpgti 88
Cdd:smart01040   1 KVRTVLIDGEPWFVAKDVARALGYSNPRDAIRKLDDDEKRVAGtelldtLGGKQEVRIISESGLYRLIMRSRKPE----- 75

                           90
                   ....*....|....
gi 694061918    89 PYRFRKWVTSEVLP 102
Cdd:smart01040  76 AKKFRRWVTDEVLP 89
Bro-N pfam02498
BRO family, N-terminal domain; This family includes the N-terminus of baculovirus BRO and ALI ...
 15-102 5.73e-21

BRO family, N-terminal domain; This family includes the N-terminus of baculovirus BRO and ALI motif proteins. The function of BRO proteins is unknown. It has been suggested that BRO-A and BRO-C are DNA binding proteins that influence host DNA replication and/or transcription. This Pfam domain does not include the characteriztic invariant alanine, leucine, isoleucine motif of the ALI proteins.


Pssm-ID: 376797  Cd Length: 96  Bit Score: 83.56  E-value: 5.73e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694061918   15 QIRAVI-INGEPWFVAADVIKALQLTNPTMSM-KALDEDERSKLN-----------LGRQGTANIISESGLYTLILRCRD 81
Cdd:pfam02498   1 EIRTVVdENGEPWFVAKDVAKALGYTNPNKAIkKHVDKANKKCLNelvntldhedgKNGHPKTVFINEAGLYLLIMRSDK 80

                          90       100
                  ....*....|....*....|.
gi 694061918   82 AVtpgtiPYRFRKWVTSEVLP 102
Cdd:pfam02498  81 PK-----AEEFRKWVTQEVLP 96
 
Name Accession Description Interval E-value
COG3617 COG3617
Prophage antirepressor [Mobilome: prophages, transposons];
1-108 1.68e-44

Prophage antirepressor [Mobilome: prophages, transposons];


Pssm-ID: 442835  Cd Length: 106  Bit Score: 144.27  E-value: 1.68e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694061918   1 MNTKPSVFSFESsNQIRAVIINGEPWFVAADVIKALQLTNPTMSMKALDEDERSKLNL----GRQGTaNIISESGLYTLI 76
Cdd:COG3617    1 MNNLITVFNFEG-HEVRTVEIDGEPWFVAKDVARALGYSNPSDALKHLDDDEKTKLELdtpgGPQEM-LFISESGLYRLI 78

                         90       100       110
                 ....*....|....*....|....*....|..
gi 694061918  77 LRCRDAVTPgtipyRFRKWVTSEVLPQIRKTG 108
Cdd:COG3617   79 LRSRKPEAK-----RFKRWVTDEVLPSIRKTG 105
Bro-N smart01040
BRO family, N-terminal domain; This family includes the N-terminus of baculovirus BRO and ALI ...
 15-102 1.19e-32

BRO family, N-terminal domain; This family includes the N-terminus of baculovirus BRO and ALI motif proteins. The function of BRO proteins is unknown. It has been suggested that BRO-A and BRO-C are DNA binding proteins that influence host DNA replication and/or transcription. This Pfam domain does not include the characteristic invariant alanine, leucine, isoleucine motif of the ALI proteins.


Pssm-ID: 214989  Cd Length: 89  Bit Score: 113.44  E-value: 1.19e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694061918    15 QIRAVIINGEPWFVAADVIKALQLTNPTMSMKALDEDERSKLN------LGRQGTANIISESGLYTLILRCRDAVtpgti 88
Cdd:smart01040   1 KVRTVLIDGEPWFVAKDVARALGYSNPRDAIRKLDDDEKRVAGtelldtLGGKQEVRIISESGLYRLIMRSRKPE----- 75

                           90
                   ....*....|....
gi 694061918    89 PYRFRKWVTSEVLP 102
Cdd:smart01040  76 AKKFRRWVTDEVLP 89
Bro-N pfam02498
BRO family, N-terminal domain; This family includes the N-terminus of baculovirus BRO and ALI ...
 15-102 5.73e-21

BRO family, N-terminal domain; This family includes the N-terminus of baculovirus BRO and ALI motif proteins. The function of BRO proteins is unknown. It has been suggested that BRO-A and BRO-C are DNA binding proteins that influence host DNA replication and/or transcription. This Pfam domain does not include the characteriztic invariant alanine, leucine, isoleucine motif of the ALI proteins.


Pssm-ID: 376797  Cd Length: 96  Bit Score: 83.56  E-value: 5.73e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694061918   15 QIRAVI-INGEPWFVAADVIKALQLTNPTMSM-KALDEDERSKLN-----------LGRQGTANIISESGLYTLILRCRD 81
Cdd:pfam02498   1 EIRTVVdENGEPWFVAKDVAKALGYTNPNKAIkKHVDKANKKCLNelvntldhedgKNGHPKTVFINEAGLYLLIMRSDK 80

                          90       100
                  ....*....|....*....|.
gi 694061918   82 AVtpgtiPYRFRKWVTSEVLP 102
Cdd:pfam02498  81 PK-----AEEFRKWVTQEVLP 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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