NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|695351790|ref|WP_032545875|]
View 

MULTISPECIES: calcium/sodium antiporter [Vibrio]

Protein Classification

sodium:calcium antiporter( domain architecture ID 11424992)

sodium:calcium antiporter facilitates Na(+)/Ca(2+) exchange

Gene Ontology:  GO:0008273|GO:0006874
PubMed:  22287543|23506883
SCOP:  4006475
TCDB:  2.A.19

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
22-321 2.70e-66

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


:

Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 209.99  E-value: 2.70e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790  22 ADRLISASATYAKHCNISLIFIGMTVVAFGTSAPELLVSAVAALNNAGELAVGNGIGSNIINIGLVLSIAVLMAPIQANK 101
Cdd:COG0530    1 ADLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRPLAVDR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790 102 RFIKKEFPILAGSMLICSALMSTGKLNITDGLLLVIFLAVYCFYLAKSVRQGEVSEDDLEFLPLTKKRAGWESLVMLLLL 181
Cdd:COG0530   81 RVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYLIRRARKEPAWEEVEEELEEKPKMSLWKALLLLVLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790 182 LTSSRL----MVWGAVNLAQLAGLSELTIGLTIIAFGTSLPELAAAIAGVRRGMYDIVFATVIGSNIFNLLGVIAIPSIV 257
Cdd:COG0530  161 LALLVVgarlLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLVLGIGALI 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695351790 258 GqELIIPEQVVSRDIPYMIILTGVLGVMLAvpllksqsssnkqATYTLHRWGGTLPLMIFIAYL 321
Cdd:COG0530  241 T-PIPVDPAVLSFDLPVMLAATLLLLGLLR-------------TGGRIGRWEGLLLLALYLAYL 290
 
Name Accession Description Interval E-value
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
22-321 2.70e-66

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 209.99  E-value: 2.70e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790  22 ADRLISASATYAKHCNISLIFIGMTVVAFGTSAPELLVSAVAALNNAGELAVGNGIGSNIINIGLVLSIAVLMAPIQANK 101
Cdd:COG0530    1 ADLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRPLAVDR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790 102 RFIKKEFPILAGSMLICSALMSTGKLNITDGLLLVIFLAVYCFYLAKSVRQGEVSEDDLEFLPLTKKRAGWESLVMLLLL 181
Cdd:COG0530   81 RVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYLIRRARKEPAWEEVEEELEEKPKMSLWKALLLLVLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790 182 LTSSRL----MVWGAVNLAQLAGLSELTIGLTIIAFGTSLPELAAAIAGVRRGMYDIVFATVIGSNIFNLLGVIAIPSIV 257
Cdd:COG0530  161 LALLVVgarlLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLVLGIGALI 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695351790 258 GqELIIPEQVVSRDIPYMIILTGVLGVMLAvpllksqsssnkqATYTLHRWGGTLPLMIFIAYL 321
Cdd:COG0530  241 T-PIPVDPAVLSFDLPVMLAATLLLLGLLR-------------TGGRIGRWEGLLLLALYLAYL 290
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 11-320 4.56e-50

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 168.66  E-value: 4.56e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790   11 LSIGLVLVAFSADRLISASATYAKHCNISLIFIGMTVVAFGTSAPELLVSAVAALNNAGELAVGNGIGSNIINIGLVLSI 90
Cdd:TIGR00367   7 LILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLILGL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790   91 AVLMAPIQANKRFIKKEFPILAGSMLICSALMSTGKLNITDGLLLVIFLAVYCFYLAKSVRQGEVSE------DDLEFLP 164
Cdd:TIGR00367  87 SAIFSPIIVDKDWLRRDILFYLLVSILLLFFGLDGQISRIDGVVLLILYIVYLLFLVKNERWVKYDTyteenlDENNRRP 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790  165 LTKKRAGWeSLVMLLLLLTSSRLMVWGAVNLAQLAGLSELTIGLTIIAFGTSLPELAAAIAGVRRGMYDIVFATVIGSNI 244
Cdd:TIGR00367 167 QIFFSLVL-LIIGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIGSNI 245

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 695351790  245 FNLLGVIAIPSIVGQELIIPEqVVSRDIPYMIILTgvlgvmLAVPLLKSQSSSnkqatytLHRWGGTLPLMIFIAY 320
Cdd:TIGR00367 246 FNILVGLGVPSLFMPIPVEPL-AYNLDAPVMVIVT------LLLMLFFKTSMK-------LGRWEGILLLALYIAY 307
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 5-322 7.93e-50

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 168.67  E-value: 7.93e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790   5 LLPSLALSIGLVLVAFSADRLISASATYAKHCNISLIFIGMTVVAFGTSAPELLVSAVAALNNAGELAVGNGIGSNIINI 84
Cdd:PRK10734   2 LLATALLIIGLLLLVYGADRLVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790  85 GLVLSIAVLMAPIQANKRFIKKEFPILAGSMLICSALMSTGKLNITDGLLLVIFLAVYCFYLAKSVRQGEVSEDD----- 159
Cdd:PRK10734  82 LLILGLAALIRPFTVHSDVLRRELPLMLLVSVLAGSVLYDGQLSRSDGIFLLLLAVLWLLFIVKIARLAERQGNDsltre 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790 160 -LEFLPL--TKKRAGWESLVMLLLLLTSSRLMVWGAVNLAQLAGLSELTIGLTIIAFGTSLPELAAAIAGVRRGMYDIVF 236
Cdd:PRK10734 162 qLAELPRegGLPVAFLWLGIALIIMPMATRMVIDNATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAV 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790 237 ATVIGSNIFNLLGVIAIPSIVGQELIIPEqVVSRDIPYMIILTgvlgVMLAVPLLKSQSSSNKQAtytlhrwgGTLPLMI 316
Cdd:PRK10734 242 GNIIGSNIFNIVIVLGLPALISPGEINPL-AFSRDYWVMLLVS----VIFALLCWRRKRRIGRGA--------GALLLGG 308


                 ....*.
gi 695351790 317 FIAYLT 322
Cdd:PRK10734 309 FIVWLA 314
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 13-146 5.05e-16

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 73.79  E-value: 5.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790   13 IGLVLVAFSADRLISASATYAKHCNISLIFIGMTVVAFGTSAPELLVSAVAALNNAGELAVGNGIGSNIINIGLVLSIAV 92
Cdd:pfam01699   8 LGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNILLVLGLSA 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790   93 LMAPIQANKRFIKKEFPILAGSMLICSALM------STGKLNITDGLLLVIFLAVYCFYL 146
Cdd:pfam01699  88 LIGPVKVDSLLLKLDLGVLLLVALLLLLLLlllllpLFGRLSRFEGLVLLLLYIVYLVFQ 147
 
Name Accession Description Interval E-value
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
22-321 2.70e-66

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 209.99  E-value: 2.70e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790  22 ADRLISASATYAKHCNISLIFIGMTVVAFGTSAPELLVSAVAALNNAGELAVGNGIGSNIINIGLVLSIAVLMAPIQANK 101
Cdd:COG0530    1 ADLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRPLAVDR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790 102 RFIKKEFPILAGSMLICSALMSTGKLNITDGLLLVIFLAVYCFYLAKSVRQGEVSEDDLEFLPLTKKRAGWESLVMLLLL 181
Cdd:COG0530   81 RVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYLIRRARKEPAWEEVEEELEEKPKMSLWKALLLLVLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790 182 LTSSRL----MVWGAVNLAQLAGLSELTIGLTIIAFGTSLPELAAAIAGVRRGMYDIVFATVIGSNIFNLLGVIAIPSIV 257
Cdd:COG0530  161 LALLVVgarlLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLVLGIGALI 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695351790 258 GqELIIPEQVVSRDIPYMIILTGVLGVMLAvpllksqsssnkqATYTLHRWGGTLPLMIFIAYL 321
Cdd:COG0530  241 T-PIPVDPAVLSFDLPVMLAATLLLLGLLR-------------TGGRIGRWEGLLLLALYLAYL 290
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 11-320 4.56e-50

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 168.66  E-value: 4.56e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790   11 LSIGLVLVAFSADRLISASATYAKHCNISLIFIGMTVVAFGTSAPELLVSAVAALNNAGELAVGNGIGSNIINIGLVLSI 90
Cdd:TIGR00367   7 LILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLILGL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790   91 AVLMAPIQANKRFIKKEFPILAGSMLICSALMSTGKLNITDGLLLVIFLAVYCFYLAKSVRQGEVSE------DDLEFLP 164
Cdd:TIGR00367  87 SAIFSPIIVDKDWLRRDILFYLLVSILLLFFGLDGQISRIDGVVLLILYIVYLLFLVKNERWVKYDTyteenlDENNRRP 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790  165 LTKKRAGWeSLVMLLLLLTSSRLMVWGAVNLAQLAGLSELTIGLTIIAFGTSLPELAAAIAGVRRGMYDIVFATVIGSNI 244
Cdd:TIGR00367 167 QIFFSLVL-LIIGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIGSNI 245

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 695351790  245 FNLLGVIAIPSIVGQELIIPEqVVSRDIPYMIILTgvlgvmLAVPLLKSQSSSnkqatytLHRWGGTLPLMIFIAY 320
Cdd:TIGR00367 246 FNILVGLGVPSLFMPIPVEPL-AYNLDAPVMVIVT------LLLMLFFKTSMK-------LGRWEGILLLALYIAY 307
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 5-322 7.93e-50

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 168.67  E-value: 7.93e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790   5 LLPSLALSIGLVLVAFSADRLISASATYAKHCNISLIFIGMTVVAFGTSAPELLVSAVAALNNAGELAVGNGIGSNIINI 84
Cdd:PRK10734   2 LLATALLIIGLLLLVYGADRLVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790  85 GLVLSIAVLMAPIQANKRFIKKEFPILAGSMLICSALMSTGKLNITDGLLLVIFLAVYCFYLAKSVRQGEVSEDD----- 159
Cdd:PRK10734  82 LLILGLAALIRPFTVHSDVLRRELPLMLLVSVLAGSVLYDGQLSRSDGIFLLLLAVLWLLFIVKIARLAERQGNDsltre 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790 160 -LEFLPL--TKKRAGWESLVMLLLLLTSSRLMVWGAVNLAQLAGLSELTIGLTIIAFGTSLPELAAAIAGVRRGMYDIVF 236
Cdd:PRK10734 162 qLAELPRegGLPVAFLWLGIALIIMPMATRMVIDNATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAV 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790 237 ATVIGSNIFNLLGVIAIPSIVGQELIIPEqVVSRDIPYMIILTgvlgVMLAVPLLKSQSSSNKQAtytlhrwgGTLPLMI 316
Cdd:PRK10734 242 GNIIGSNIFNIVIVLGLPALISPGEINPL-AFSRDYWVMLLVS----VIFALLCWRRKRRIGRGA--------GALLLGG 308


                 ....*.
gi 695351790 317 FIAYLT 322
Cdd:PRK10734 309 FIVWLA 314
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
9-146 5.71e-21

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 90.96  E-value: 5.71e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790   9 LALSIGLVLVAFSADRLISASATYAKHCNISLIFIGMTVVAFGTSAPELLVSAVAALNNAGELAVGNGIGSNIINIGLVL 88
Cdd:COG0530  155 LLLVLGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLVL 234

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 695351790  89 SIAVLMAPIQANKRFIKKEFPILAGSMLICSALM-STGKLNITDGLLLVIFLAVYCFYL 146
Cdd:COG0530  235 GIGALITPIPVDPAVLSFDLPVMLAATLLLLGLLrTGGRIGRWEGLLLLALYLAYLALL 293
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 13-146 5.05e-16

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 73.79  E-value: 5.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790   13 IGLVLVAFSADRLISASATYAKHCNISLIFIGMTVVAFGTSAPELLVSAVAALNNAGELAVGNGIGSNIINIGLVLSIAV 92
Cdd:pfam01699   8 LGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNILLVLGLSA 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790   93 LMAPIQANKRFIKKEFPILAGSMLICSALM------STGKLNITDGLLLVIFLAVYCFYL 146
Cdd:pfam01699  88 LIGPVKVDSLLLKLDLGVLLLVALLLLLLLlllllpLFGRLSRFEGLVLLLLYIVYLVFQ 147
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 188-322 1.63e-13

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 66.86  E-value: 1.63e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790  188 MVWGAVNLAQLAGLSELTIGLTIIAFGTSLPELAAAIAGVRRGMYDIVFATVIGSNIFNLLGVIAIPSIVGQeLIIPEQV 267
Cdd:pfam01699  20 LVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNILLVLGLSALIGP-VKVDSLL 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 695351790  268 VSRDIPYMIILTGVLGVMLAVPLLksqsssnkQATYTLHRWGGTLPLMIFIAYLT 322
Cdd:pfam01699  99 LKLDLGVLLLVALLLLLLLLLLLL--------PLFGRLSRFEGLVLLLLYIVYLV 145
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 9-142 9.50e-13

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 67.73  E-value: 9.50e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790    9 LALSIGLVLVAFSADRLISASATYAKHCNISLIFIGMTVVAFGTSAPELLVSAVAALNNAGELAVGNGIGSNIINIGLVL 88
Cdd:TIGR00367 173 VLLIIGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIGSNIFNILVGL 252

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 695351790   89 SIAVLMAPIQANKRFIKKEFPILAGSMLICSALMST-GKLNITDGLLLVIFLAVY 142
Cdd:TIGR00367 253 GVPSLFMPIPVEPLAYNLDAPVMVIVTLLLMLFFKTsMKLGRWEGILLLALYIAY 307
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 188-254 5.53e-10

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 60.78  E-value: 5.53e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 695351790   188 MVWGAVNLAQLAGLSELTIGLTIIAFGTSLPELAAAIAGVRRGMYDIVFATVIGSNIFNLLGVIAIP 254
Cdd:TIGR00927  952 MVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVP 1018
caca2 TIGR00846
calcium/proton exchanger; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the ...
 11-143 2.78e-06

calcium/proton exchanger; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is generated from the calcium ion/proton exchangers of the CacA family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273297 [Multi-domain]  Cd Length: 363  Bit Score: 48.61  E-value: 2.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790   11 LSIGLVLVAFSADRLISASATYAKHCNISLIFIGMTVVAFGTSAPELLVSAVAALNNAGELAVGNGIGSNIINIGLVLSI 90
Cdd:TIGR00846 224 LVGTTIAIILLADYLVDTIDDAVDSWGLSVAFIGLILAPIVGNAAEHVTAVKAALKNKLDLALGVALGSALQIILFVVPL 303

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 695351790   91 AVLMAPIQANK---RFIKKEFPILAGSMLICSALMSTGKLNITDGLLLVIFLAVYC 143
Cdd:TIGR00846 304 VVLVAWMLGIPmdlNFGTFETIVLALSLFLTTITLQDGRSNYLEGAVLLALYIIIA 359
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 38-94 1.13e-05

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 47.30  E-value: 1.13e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 695351790    38 ISLIFIGMTVVAFGTSAPELLVSAVAALNNAGELAVGNGIGSNIINIGLVLSIAVLM 94
Cdd:TIGR00927  965 ISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLL 1021
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 48-97 2.19e-04

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 42.86  E-value: 2.19e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 695351790   48 VAFGTSAPELLVSAVAALNNAG-ELAVGNGIGSNIINIGLVLSIAVLMAPI 97
Cdd:TIGR00845 796 VALGTSVPDTFASKVAATQDQYaDASIGNVTGSNAVNVFLGIGVAWSIAAI 846
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 201-277 6.19e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 41.52  E-value: 6.19e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 695351790   201 LSELTIGLTIIAFGTSLPELAAAIAGVRRGMYDIVFATVIGSNIFNLLGVIAIPSIVGQELI-IPEQVVSRDIPYMII 277
Cdd:TIGR00927  492 ISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILnLTWWPLFRDVSFYIL 569
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 45-147 2.93e-03

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 39.39  E-value: 2.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695351790   45 MTVVAFGTSAPELLVSAVAALNN---AGELAVGNGIGSNIINIGLVLSIAVLMAPIQANKR-------FIKKEFPILAGS 114
Cdd:TIGR00845 134 LTLMALGSSAPEILLSVIEVCGHnfeAGDLGPSTIVGSAAFNMFIIIAICVYVIPDGETRKikhlrvfFVTAAWSVFAYV 213

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 695351790  115 ML-ICSALMSTGKLNITDGLLLVIF--LAVYCFYLA 147
Cdd:TIGR00845 214 WLyLILAVFSPGVVEVWEGLLTFFFfpLCVVFAWVA 249
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH