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Conserved domains on  [gi|695634967|ref|WP_032612185|]
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MULTISPECIES: KilA-N domain-containing protein [Enterobacteriaceae]

Protein Classification

KilA-N domain-containing protein; RING finger protein( domain architecture ID 10516320)

KilA-N domain-containing protein is a DNA-binding protein such as Saccharomyces cerevisiae transcription factor PHD1 that functions in pseudohyphal growth| RING finger protein may function as an E3 ubiquitin protein ligase that mediates the ubiquitination of target proteins by bringing the ubiquitin-charged E2 ubiquitin-conjugating enzyme and the acceptor protein together to enable the direct transfer of ubiquitin; similar to Homo sapiens E3 ubiquitin-protein ligase RNF10

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KilA-N pfam04383
KilA-N domain; The amino-terminal module of the D6R/N1R proteins defines a novel, conserved ...
 11-102 1.53e-17

KilA-N domain; The amino-terminal module of the D6R/N1R proteins defines a novel, conserved DNA-binding domain (the KilA-N domain) that is found in a wide range of proteins of large bacterial and eukaryotic DNA viruses. The KilA-N domain family also includes the previously defined APSES domain. The KilA-N and APSES domains may also share a common fold with the nucleic acid-binding modules of the LAGLIDADG nucleases and the amino-terminal domains of the tRNA endonuclease.


:

Pssm-ID: 367917  Cd Length: 107  Bit Score: 73.51  E-value: 1.53e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695634967   11 IRVGEDGMICLTDMWKASGkSDAESPYHYLRNKQTKEFLAELEK---NHESVVFTARGVHGGTYGGKFV----AYDYAAW 83
Cdd:pfam04383  10 IRRDKDGYINATKLCKAAG-EKTKRFRNWLRLESTKELIEELEEennIPKIITIIGRKGKGGRLQGTYVhpdlALAIASW 88

                          90
                  ....*....|....*....
gi 695634967   84 LNPGFKYAAYKVLDDYFTG 102
Cdd:pfam04383  89 ISPEFALKVSKIIDEYKSG 107
ORF11CD3 super family cl11180
ORF11CD3 domain; This domain was identified by Iyer and colleagues.
 110-161 1.75e-13

ORF11CD3 domain; This domain was identified by Iyer and colleagues.


The actual alignment was detected with superfamily member pfam10549:

Pssm-ID: 287514  Cd Length: 52  Bit Score: 61.31  E-value: 1.75e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 695634967  110 LSAQLNMKCHEFDQKKDMASFCGQGLAAWRYTKPVLVAEINTLANQLQITIP 161
Cdd:pfam10549   1 LMHEFNEACIELKKQKRIASLAGRGLNEWKQVKPQLTQKVESLEEKLQPTLP 52
 
Name Accession Description Interval E-value
KilA-N pfam04383
KilA-N domain; The amino-terminal module of the D6R/N1R proteins defines a novel, conserved ...
 11-102 1.53e-17

KilA-N domain; The amino-terminal module of the D6R/N1R proteins defines a novel, conserved DNA-binding domain (the KilA-N domain) that is found in a wide range of proteins of large bacterial and eukaryotic DNA viruses. The KilA-N domain family also includes the previously defined APSES domain. The KilA-N and APSES domains may also share a common fold with the nucleic acid-binding modules of the LAGLIDADG nucleases and the amino-terminal domains of the tRNA endonuclease.


Pssm-ID: 367917  Cd Length: 107  Bit Score: 73.51  E-value: 1.53e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695634967   11 IRVGEDGMICLTDMWKASGkSDAESPYHYLRNKQTKEFLAELEK---NHESVVFTARGVHGGTYGGKFV----AYDYAAW 83
Cdd:pfam04383  10 IRRDKDGYINATKLCKAAG-EKTKRFRNWLRLESTKELIEELEEennIPKIITIIGRKGKGGRLQGTYVhpdlALAIASW 88

                          90
                  ....*....|....*....
gi 695634967   84 LNPGFKYAAYKVLDDYFTG 102
Cdd:pfam04383  89 ISPEFALKVSKIIDEYKSG 107
ORF11CD3 pfam10549
ORF11CD3 domain; This domain was identified by Iyer and colleagues.
 110-161 1.75e-13

ORF11CD3 domain; This domain was identified by Iyer and colleagues.


Pssm-ID: 287514  Cd Length: 52  Bit Score: 61.31  E-value: 1.75e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 695634967  110 LSAQLNMKCHEFDQKKDMASFCGQGLAAWRYTKPVLVAEINTLANQLQITIP 161
Cdd:pfam10549   1 LMHEFNEACIELKKQKRIASLAGRGLNEWKQVKPQLTQKVESLEEKLQPTLP 52
 
Name Accession Description Interval E-value
KilA-N pfam04383
KilA-N domain; The amino-terminal module of the D6R/N1R proteins defines a novel, conserved ...
 11-102 1.53e-17

KilA-N domain; The amino-terminal module of the D6R/N1R proteins defines a novel, conserved DNA-binding domain (the KilA-N domain) that is found in a wide range of proteins of large bacterial and eukaryotic DNA viruses. The KilA-N domain family also includes the previously defined APSES domain. The KilA-N and APSES domains may also share a common fold with the nucleic acid-binding modules of the LAGLIDADG nucleases and the amino-terminal domains of the tRNA endonuclease.


Pssm-ID: 367917  Cd Length: 107  Bit Score: 73.51  E-value: 1.53e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695634967   11 IRVGEDGMICLTDMWKASGkSDAESPYHYLRNKQTKEFLAELEK---NHESVVFTARGVHGGTYGGKFV----AYDYAAW 83
Cdd:pfam04383  10 IRRDKDGYINATKLCKAAG-EKTKRFRNWLRLESTKELIEELEEennIPKIITIIGRKGKGGRLQGTYVhpdlALAIASW 88

                          90
                  ....*....|....*....
gi 695634967   84 LNPGFKYAAYKVLDDYFTG 102
Cdd:pfam04383  89 ISPEFALKVSKIIDEYKSG 107
ORF11CD3 pfam10549
ORF11CD3 domain; This domain was identified by Iyer and colleagues.
 110-161 1.75e-13

ORF11CD3 domain; This domain was identified by Iyer and colleagues.


Pssm-ID: 287514  Cd Length: 52  Bit Score: 61.31  E-value: 1.75e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 695634967  110 LSAQLNMKCHEFDQKKDMASFCGQGLAAWRYTKPVLVAEINTLANQLQITIP 161
Cdd:pfam10549   1 LMHEFNEACIELKKQKRIASLAGRGLNEWKQVKPQLTQKVESLEEKLQPTLP 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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