|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07006 |
PRK07006 |
isocitrate dehydrogenase; Reviewed |
8-416 |
0e+00 |
|
isocitrate dehydrogenase; Reviewed
Pssm-ID: 180792 Cd Length: 409 Bit Score: 904.05 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 8 PAEGKKITLQNGKINVPHNPIIPFIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87
Cdd:PRK07006 1 PAEGEKITVNNGKLNVPNNPIIPFIEGDGIGPDITPAMLKVVDAAVEKAYKGERKISWMEIYAGEKATKVYGEDVWLPEE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 88 TLDLIRDYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKA 167
Cdd:PRK07006 81 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYFKGVPSPVKRPEDTDMVIFRENSEDIYAGIEWKA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 168 DSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEDGTKRLVRAAIEYAITNDRDSVTLVHKGNIMKFTEGAFKDWGYQ 247
Cdd:PRK07006 161 GSAEAKKVIKFLQEEMGVKKIRFPETSGIGIKPVSEEGTERLVRAAIEYAIDNDRKSVTLVHKGNIMKFTEGAFKDWGYQ 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 248 LAKEEFGGELIDGGPWQKIKNPNTGKEIIIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327
Cdd:PRK07006 241 LAEEEFGDELIDGGPWDKIKNPETGKEIIVKDSIADAFLQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGAN 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMEWFEAADLIVKGMEGAINAKTVTYDFERLMEGAKLLKCSE 407
Cdd:PRK07006 321 INDGHAIFEATHGTAPKYAGLDKVNPGSVILSAEMMLRHMGWTEAADLIIKSMEKTIASKTVTYDFARLMEGATEVKCSE 400
|
....*....
gi 695731456 408 FGDAIIANM 416
Cdd:PRK07006 401 FGDALIKNM 409
|
|
| prok_nadp_idh |
TIGR00183 |
isocitrate dehydrogenase, NADP-dependent, prokaryotic type; Several NAD- or NADP-dependent ... |
1-416 |
0e+00 |
|
isocitrate dehydrogenase, NADP-dependent, prokaryotic type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; Prokaryotic NADP-dependent isocitrate dehydrogenases resemble their NAD-dependent counterparts and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent isocitrate dehydrogenases. [Energy metabolism, TCA cycle]
Pssm-ID: 272948 Cd Length: 416 Bit Score: 819.46 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 1 MESKVVVPAEGKKITLQNGKINVPHNPIIPFIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80
Cdd:TIGR00183 1 MYEKVKPPAQGEKITYENGKLNVPNNPIIPYIEGDGIGVDVTPAAIKVLDAAVEKAYKGEKKIVWFEVYAGEKAYQLYGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 81 DVWLPAETLDLIRDYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIY 160
Cdd:TIGR00183 81 DQWLPADTLDAIKEYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYKGVPSPVKHPEKVDMVIFRENTEDIY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 161 AGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEDGTKRLVRAAIEYAITNDRDSVTLVHKGNIMKFTEGA 240
Cdd:TIGR00183 161 AGIEWAEGSEEAKKLIRFLQNELGVKKIRFPEDSGIGIKPISEEGTKRLVRAAIEYAIENDRKSVTLVHKGNIMKFTEGA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 241 FKDWGYQLAKEEFGGELIDGGPWQKIKNPNTGKEIIIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320
Cdd:TIGR00183 241 FRDWGYELAKKEFGAECITWGLWDKYKNPNPGKEIVIKDRIADAFLQQILTRPDEYDVIATMNLNGDYISDALAAQVGGI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 321 GIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMEWFEAADLIVKGMEGAINAKTVTYDFERLMEGA 400
Cdd:TIGR00183 321 GIAPGANIGDEIGIFEATHGTAPKYAGQDKVNPGSIILSGEMMLEHMGWKEAADLIKKAMEKAIASKIVTYDFARLMDGA 400
|
410
....*....|....*.
gi 695731456 401 KLLKCSEFGDAIIANM 416
Cdd:TIGR00183 401 KEVKCSEFAEAIIENM 416
|
|
| Icd |
COG0538 |
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ... |
10-416 |
0e+00 |
|
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440304 Cd Length: 409 Bit Score: 784.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 10 EGKKITLQNGKINVPHNPIIPFIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQdvWLPAETL 89
Cdd:COG0538 2 EGEKIKVEDGKLKVPDNPIIPFIEGDGIGPEITRAIWKVIDAAVEKAYGGKRDIEWKEVDAGEKARDETGD--WLPDETA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 90 DLIRDYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADS 169
Cdd:COG0538 80 EAIKEYGVGIKGPLTTPVGGGWRSLNVTIRQILDLYVCRRPVRYFKGVPSPVKHPEKVDIVIFRENTEDIYAGIEWKAGS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 170 ADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEDGTKRLVRAAIEYAITNDRDSVTLVHKGNIMKFTEGAFKDWGYQLA 249
Cdd:COG0538 160 PEALKLIFFLEDEMGVTVIRFPEDSGIGIKPVSDEGTERLVRAAIQYALDNKRKSVTLVHKGNIMKFTEGAFKDWGYEVA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 250 KEEFGGELIDGGPWQKIKNPNTGKEIIIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIG 329
Cdd:COG0538 240 EEEFGDKFITEGPWEKYKGPKPAGKIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 330 DEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMEWFEAADLIVKGMEGAINAKTVTYDFERLMEGAKLLKCSEF 408
Cdd:COG0538 320 DDGgAEFEATHGTAPKYAGKDSTNPGSLILSGTMMLRHRGWLEAADLIEKAVEKTIESGKVTYDLARLMEGATELSTSEF 399
|
....*...
gi 695731456 409 GDAIIANM 416
Cdd:COG0538 400 GDAIIENL 407
|
|
| Iso_dh |
pfam00180 |
Isocitrate/isopropylmalate dehydrogenase; |
28-412 |
2.63e-110 |
|
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507 Cd Length: 346 Bit Score: 327.71 E-value: 2.63e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 28 IIPFIEGDGIGVDVTPAMLKVVDAAVEKAYKgerKISWMEIYTGEKSTQVYGQdvWLPAETLDLIRDYRVAIKGPLTTPV 107
Cdd:pfam00180 1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPL---EFEFEERDVGGAAIDETGE--PLPDETLEACKKADAVLLGAVGGPK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 108 G--GGIRSLN--VALRQELDLYVCLRPVRYYQGT--PSPVK-HPELTDMVIFRENSEDIYAGIEWKADSADAEKvikflr 180
Cdd:pfam00180 76 WdpAGVRPENglLALRKELGLFANLRPAKVFPPLgdASPLKnEVEGVDIVIVRELTGGIYFGIEKGIKGSGNEV------ 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 181 eemgvkkirfpehcGIGIKPCSEDGTKRLVRAAIEYAITNDRDSVTLVHKGNIMKFTEGaFKDWGYQLAKEEFGgelidg 260
Cdd:pfam00180 150 --------------AVDTKLYSRDEIERIARVAFELARKRGRKKVTSVDKANVLKSSDL-WRKIVTEVAKAEYP------ 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 261 gpwqkiknpntgkEIIIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDEC-ALFEATH 339
Cdd:pfam00180 209 -------------DVELEHQLVDNAAMQLVKNPSQFDVIVTPNLFGDILSDEASMLTGSLGLLPSASLGANGfGIFEPVH 275
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695731456 340 GTAPKYAGQDKVNPGSIILSAEMMLRH-MEWFEAADLIVKGMEGAINAKTVTYDferLMEGAKLLKCSEFGDAI 412
Cdd:pfam00180 276 GSAPDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEAAVLKVLESGIRTGD---LAGSATYVSTSEFGEAV 346
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07006 |
PRK07006 |
isocitrate dehydrogenase; Reviewed |
8-416 |
0e+00 |
|
isocitrate dehydrogenase; Reviewed
Pssm-ID: 180792 Cd Length: 409 Bit Score: 904.05 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 8 PAEGKKITLQNGKINVPHNPIIPFIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAE 87
Cdd:PRK07006 1 PAEGEKITVNNGKLNVPNNPIIPFIEGDGIGPDITPAMLKVVDAAVEKAYKGERKISWMEIYAGEKATKVYGEDVWLPEE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 88 TLDLIRDYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKA 167
Cdd:PRK07006 81 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYFKGVPSPVKRPEDTDMVIFRENSEDIYAGIEWKA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 168 DSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEDGTKRLVRAAIEYAITNDRDSVTLVHKGNIMKFTEGAFKDWGYQ 247
Cdd:PRK07006 161 GSAEAKKVIKFLQEEMGVKKIRFPETSGIGIKPVSEEGTERLVRAAIEYAIDNDRKSVTLVHKGNIMKFTEGAFKDWGYQ 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 248 LAKEEFGGELIDGGPWQKIKNPNTGKEIIIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327
Cdd:PRK07006 241 LAEEEFGDELIDGGPWDKIKNPETGKEIIVKDSIADAFLQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGAN 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 328 IGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMEWFEAADLIVKGMEGAINAKTVTYDFERLMEGAKLLKCSE 407
Cdd:PRK07006 321 INDGHAIFEATHGTAPKYAGLDKVNPGSVILSAEMMLRHMGWTEAADLIIKSMEKTIASKTVTYDFARLMEGATEVKCSE 400
|
....*....
gi 695731456 408 FGDAIIANM 416
Cdd:PRK07006 401 FGDALIKNM 409
|
|
| prok_nadp_idh |
TIGR00183 |
isocitrate dehydrogenase, NADP-dependent, prokaryotic type; Several NAD- or NADP-dependent ... |
1-416 |
0e+00 |
|
isocitrate dehydrogenase, NADP-dependent, prokaryotic type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; Prokaryotic NADP-dependent isocitrate dehydrogenases resemble their NAD-dependent counterparts and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent isocitrate dehydrogenases. [Energy metabolism, TCA cycle]
Pssm-ID: 272948 Cd Length: 416 Bit Score: 819.46 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 1 MESKVVVPAEGKKITLQNGKINVPHNPIIPFIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80
Cdd:TIGR00183 1 MYEKVKPPAQGEKITYENGKLNVPNNPIIPYIEGDGIGVDVTPAAIKVLDAAVEKAYKGEKKIVWFEVYAGEKAYQLYGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 81 DVWLPAETLDLIRDYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIY 160
Cdd:TIGR00183 81 DQWLPADTLDAIKEYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYKGVPSPVKHPEKVDMVIFRENTEDIY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 161 AGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEDGTKRLVRAAIEYAITNDRDSVTLVHKGNIMKFTEGA 240
Cdd:TIGR00183 161 AGIEWAEGSEEAKKLIRFLQNELGVKKIRFPEDSGIGIKPISEEGTKRLVRAAIEYAIENDRKSVTLVHKGNIMKFTEGA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 241 FKDWGYQLAKEEFGGELIDGGPWQKIKNPNTGKEIIIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGI 320
Cdd:TIGR00183 241 FRDWGYELAKKEFGAECITWGLWDKYKNPNPGKEIVIKDRIADAFLQQILTRPDEYDVIATMNLNGDYISDALAAQVGGI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 321 GIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMEWFEAADLIVKGMEGAINAKTVTYDFERLMEGA 400
Cdd:TIGR00183 321 GIAPGANIGDEIGIFEATHGTAPKYAGQDKVNPGSIILSGEMMLEHMGWKEAADLIKKAMEKAIASKIVTYDFARLMDGA 400
|
410
....*....|....*.
gi 695731456 401 KLLKCSEFGDAIIANM 416
Cdd:TIGR00183 401 KEVKCSEFAEAIIENM 416
|
|
| Icd |
COG0538 |
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ... |
10-416 |
0e+00 |
|
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440304 Cd Length: 409 Bit Score: 784.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 10 EGKKITLQNGKINVPHNPIIPFIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQdvWLPAETL 89
Cdd:COG0538 2 EGEKIKVEDGKLKVPDNPIIPFIEGDGIGPEITRAIWKVIDAAVEKAYGGKRDIEWKEVDAGEKARDETGD--WLPDETA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 90 DLIRDYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADS 169
Cdd:COG0538 80 EAIKEYGVGIKGPLTTPVGGGWRSLNVTIRQILDLYVCRRPVRYFKGVPSPVKHPEKVDIVIFRENTEDIYAGIEWKAGS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 170 ADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEDGTKRLVRAAIEYAITNDRDSVTLVHKGNIMKFTEGAFKDWGYQLA 249
Cdd:COG0538 160 PEALKLIFFLEDEMGVTVIRFPEDSGIGIKPVSDEGTERLVRAAIQYALDNKRKSVTLVHKGNIMKFTEGAFKDWGYEVA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 250 KEEFGGELIDGGPWQKIKNPNTGKEIIIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIG 329
Cdd:COG0538 240 EEEFGDKFITEGPWEKYKGPKPAGKIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 330 DEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMEWFEAADLIVKGMEGAINAKTVTYDFERLMEGAKLLKCSEF 408
Cdd:COG0538 320 DDGgAEFEATHGTAPKYAGKDSTNPGSLILSGTMMLRHRGWLEAADLIEKAVEKTIESGKVTYDLARLMEGATELSTSEF 399
|
....*...
gi 695731456 409 GDAIIANM 416
Cdd:COG0538 400 GDAIIENL 407
|
|
| PRK07362 |
PRK07362 |
NADP-dependent isocitrate dehydrogenase; |
1-415 |
0e+00 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 180944 Cd Length: 474 Bit Score: 553.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 1 MESKVVVPAEGKKITLQNGKINVPHNPIIPFIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQ 80
Cdd:PRK07362 3 MYEKLTPPSTGSKITFKNGKPVVPDNPIIPFIRGDGTGVDIWPATQKVLDAAVAKAYGGERKINWFKVYAGDEACDLYGT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 81 DVWLPAETLDLIRDYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIY 160
Cdd:PRK07362 83 YQYLPEDTLEAIREYGVAIKGPLTTPIGGGIRSLNVALRQIFDLYSCVRPCRYYAGTPSPHKNPEKLDVIVYRENTEDIY 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 161 AGIEWKADSADAEKVIKFLREEM-----GVKKIRFPEHCGIGIKPCSEDGTKRLVRAAIEYAIT--NDRDSVTLVHKGNI 233
Cdd:PRK07362 163 MGIEWEAGDEIGDKLIKHLNEEVipaspELGKRQIPLGSGIGIKPVSKTGSQRHIRRAIEHALRlpGDKRHVTLVHKGNI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 234 MKFTEGAFKDWGYQLAKEEFGGELI-DGGPW---QKIKNPNTGKE----------------------------------- 274
Cdd:PRK07362 243 MKYTEGAFRDWGYELATTEFRDECVtERESWilsNKEKNPNISIEdnarmiepgydsltpekkaaicaevkevldsiwss 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 275 ---------IIIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKY 345
Cdd:PRK07362 323 hgngkwkekVLVDDRIADSIFQQIQTRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNAAIFEATHGTAPKH 402
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 695731456 346 AGQDKVNPGSIILSAEMMLRHMEWFEAADLIVKGMEGAINAKTVTYDFERLMEGA-KLLKCSEFGDAIIAN 415
Cdd:PRK07362 403 AGLDRINPGSVILSGVMMLEYLGWQEAADLITKGLSAAIANKQVTYDLARLMEPPvDPLSCSEFAEAIISH 473
|
|
| PRK06451 |
PRK06451 |
NADP-dependent isocitrate dehydrogenase; |
7-416 |
9.28e-160 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 235803 Cd Length: 412 Bit Score: 456.22 E-value: 9.28e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 7 VPAEGKKITLQNGKINVPHNPIIPFIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDvwLPA 86
Cdd:PRK06451 4 IPEDGEVIKFENGKWIVPKKPIILYVEGDGIGPEITHAAMKVINKAVEKAYGSDREIKWVEVLAGDKAEKLTGNR--FPK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 87 ETLDLIRDYRVAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWK 166
Cdd:PRK06451 82 ESEELIEKYRVLLKGPLETPIGKGWKSINVAIRLMLDLYANIRPVKYIPGIESPLKNPEKIDLIIFRENTDDLYRGIEYP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 167 ADSADAEKVIKFLREEMGVKkirFPEHCGIGIKPCSEDGTKRLVRAAIEYAITNDRDSVTLVHKGNIMKFTEGAFKDWGY 246
Cdd:PRK06451 162 YDSEEAKKIRDFLRKELGVE---VEDDTGIGIKLISKFKTQRIARMAIKYAIDHKRKKVTIMHKGNVMKYTEGAFREWAY 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 247 QLAKEEFGGELIDGGPWQKIKN--PNTGKeIIIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324
Cdd:PRK06451 239 EVALKEFRDYVVTEEEVTKNYNgvPPSGK-VIINDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMEWFEAADLIVKGMEGAINAKTVTYDFERLMeGAKLLK 404
Cdd:PRK06451 318 GANIGDTGGMFEAIHGTAPKYAGKNVANPTGIIKGGELMLRFMGWDKAADLIDKAIMESIKQKKVTQDLARFM-GVRALS 396
|
410
....*....|..
gi 695731456 405 CSEFGDAIIANM 416
Cdd:PRK06451 397 TTEYTDELISII 408
|
|
| Iso_dh |
pfam00180 |
Isocitrate/isopropylmalate dehydrogenase; |
28-412 |
2.63e-110 |
|
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507 Cd Length: 346 Bit Score: 327.71 E-value: 2.63e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 28 IIPFIEGDGIGVDVTPAMLKVVDAAVEKAYKgerKISWMEIYTGEKSTQVYGQdvWLPAETLDLIRDYRVAIKGPLTTPV 107
Cdd:pfam00180 1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPL---EFEFEERDVGGAAIDETGE--PLPDETLEACKKADAVLLGAVGGPK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 108 G--GGIRSLN--VALRQELDLYVCLRPVRYYQGT--PSPVK-HPELTDMVIFRENSEDIYAGIEWKADSADAEKvikflr 180
Cdd:pfam00180 76 WdpAGVRPENglLALRKELGLFANLRPAKVFPPLgdASPLKnEVEGVDIVIVRELTGGIYFGIEKGIKGSGNEV------ 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 181 eemgvkkirfpehcGIGIKPCSEDGTKRLVRAAIEYAITNDRDSVTLVHKGNIMKFTEGaFKDWGYQLAKEEFGgelidg 260
Cdd:pfam00180 150 --------------AVDTKLYSRDEIERIARVAFELARKRGRKKVTSVDKANVLKSSDL-WRKIVTEVAKAEYP------ 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 261 gpwqkiknpntgkEIIIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDEC-ALFEATH 339
Cdd:pfam00180 209 -------------DVELEHQLVDNAAMQLVKNPSQFDVIVTPNLFGDILSDEASMLTGSLGLLPSASLGANGfGIFEPVH 275
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695731456 340 GTAPKYAGQDKVNPGSIILSAEMMLRH-MEWFEAADLIVKGMEGAINAKTVTYDferLMEGAKLLKCSEFGDAI 412
Cdd:pfam00180 276 GSAPDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEAAVLKVLESGIRTGD---LAGSATYVSTSEFGEAV 346
|
|
| LeuB |
COG0473 |
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ... |
32-416 |
1.54e-103 |
|
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440241 Cd Length: 346 Bit Score: 310.41 E-value: 1.54e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 32 IEGDGIGVDVTPAMLKVVDAAvekAYKGERKISWMEIYTGEKSTQVYGQDvwLPAETLDLIRDYRVAIKGPLTTPV---G 108
Cdd:COG0473 7 LPGDGIGPEVVAAALKVLEAA---AERFGLDFEFEEADIGGAAYDKTGTP--LPDETLEALRKADAILLGAVGGPKwddG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 109 GGIRSLNVALRQELDLYVCLRPVRYYQGTPSPVKH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVikflreemgvk 186
Cdd:COG0473 82 VRPESGLLALRKELDLYANLRPAKLYPGLPSPLKPeiVEGIDLVIVRENTEGLYFGIGGRIGTGTGEEV----------- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 187 kirfpehcGIGIKPCSEDGTKRLVRAAIEYAITNdRDSVTLVHKGNIMKFTEGAFKDWGYQLAKEefggelidggpwqki 266
Cdd:COG0473 151 --------AIDTRVYTRKGIERIARYAFELARKR-RKKVTSVDKANVLKLTSGLWREVVREVAKE--------------- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 267 kNPntgkEIIIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDEC-ALFEATHGTAPKY 345
Cdd:COG0473 207 -YP----DVELDHMYVDAAAMQLVRNPEQFDVIVTENLFGDILSDLAAGLTGSLGLAPSANIGDEGkALFEPVHGSAPDI 281
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 695731456 346 AGQDKVNPGSIILSAEMMLRHMEWFEAADLIVKGMEGAINAKTVTYDferLMEGAkllKCSEFGDAIIANM 416
Cdd:COG0473 282 AGKGIANPIATILSAAMMLRHLGEEEAADAIEAAVEKVLAEGVRTPD---LGGKA---GTSEMGDAIIAAL 346
|
|
| PRK09222 |
PRK09222 |
NADP-dependent isocitrate dehydrogenase; |
29-416 |
5.96e-84 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 236416 [Multi-domain] Cd Length: 482 Bit Score: 264.83 E-value: 5.96e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 29 IPFIEGDGIGVDVTPAMLKVVDAAvekaykgERKISWMEIYTGEKstqVY--GQDVWLPAETLDLIRDYRVAIKGPLTTP 106
Cdd:PRK09222 7 ITVAYGDGIGPEIMEAVLKILEAA-------GAPLEIETIEIGEK---VYkkGWTSGISPSAWESIRRTKVLLKAPITTP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 107 VGGGIRSLNVALRQELDLYVCLRPVRYYqgtpSPV---KHPELtDMVIFRENSEDIYAGIEWK--ADSADAEKVIkflre 181
Cdd:PRK09222 77 QGGGYKSLNVTLRKTLGLYANVRPCVSY----HPFvetKHPNL-DVVIIRENEEDLYAGIEHRqtPDVYQCLKLI----- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 182 emgvkkirfpehcgigikpcSEDGTKRLVRAAIEYAITNDRDSVTLVHKGNIMKFTEGAFKDWGYQLAKEEfggelidgg 261
Cdd:PRK09222 147 --------------------SRPGSEKIIRYAFEYARANGRKKVTCLTKDNIMKLTDGLFHKVFDEIAKEY--------- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 262 pwqkiknPNTGKEIIIKDvIADAflqQILLRPAEYDVIACMNLNGDYISDaLAAQV-GGIGIAPGANIGDECALFEATHG 340
Cdd:PRK09222 198 -------PDIEAEHYIVD-IGAA---RLATNPENFDVIVTPNLYGDILSD-IAAEIsGSVGLAGSANIGEEYAMFEAVHG 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 341 TAPKYAGQDKVNPGSIILSAEMMLRHMEWFEAADLI----VKGMEGAINaktvTYDFERLMEGAKLLKCSEFGDAIIANM 416
Cdd:PRK09222 266 SAPDIAGKNIANPSGLLNAAVMMLVHIGQFDIAELIenawLKTLEDGIH----TADIYNEGVSKKKVGTKEFAEAVIENL 341
|
|
| PRK08997 |
PRK08997 |
isocitrate dehydrogenase; Provisional |
29-390 |
2.40e-74 |
|
isocitrate dehydrogenase; Provisional
Pssm-ID: 181606 Cd Length: 334 Bit Score: 235.38 E-value: 2.40e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 29 IPFIEGDGIGVDVTPAMLKVVDAA-----VEKAYKGERKIswmeiytgEKSTQVygqdvwLPAETLDLIRDYRVAIKGPL 103
Cdd:PRK08997 5 ITVIPGDGIGPSIIDATLKILDKLgcdfeYEFADAGLTAL--------EKHGEL------LPQRTLDLIEKNKIALKGPL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 104 TTPVGGGIRSLNVALRQELDLYVCLRPVRYYQGTPSPVkhpELTDMVIFRENSEDIYAGI--EWKADSADAEKVIKFLRE 181
Cdd:PRK08997 71 TTPVGEGFTSINVTLRKKFDLYANVRPVLSFPGTKARY---DNIDIITVRENTEGMYSGEgqTVSEDGETAEATSIITRK 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 182 emgvkkirfpehcgigikpcsedGTKRLVRAAIEYAITNDRDSVTLVHKGNIMKFTEGAFKDWGYQLAKEEfggelidgg 261
Cdd:PRK08997 148 -----------------------GAERIVRFAYELARKEGRKKVTAVHKANIMKSTSGLFLKVAREVALRY--------- 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 262 pwqkiknpntgKEIIIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGT 341
Cdd:PRK08997 196 -----------PDIEFEEMIVDATCMQLVMNPEQFDVIVTTNLFGDILSDLCAGLVGGLGMAPGANIGRDAAIFEAVHGS 264
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 695731456 342 APKYAGQDKVNPGSIILSAEMMLRHMEWFEAADLIVKGMEGAINAKTVT 390
Cdd:PRK08997 265 APDIAGKNLANPTSVILAAIQMLEYLGMPDKAERIRKAIVAVIEAGDRT 313
|
|
| mito_nad_idh |
TIGR00175 |
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ... |
31-416 |
5.67e-67 |
|
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]
Pssm-ID: 272942 Cd Length: 333 Bit Score: 216.09 E-value: 5.67e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 31 FIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEkstqvygqdvwLPAETLDLIRDYRVAIKGPLTTPVG-G 109
Cdd:TIGR00175 8 LIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQTDGKTE-----------IPDEAVESIKRNKVALKGPLETPIGkG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 110 GIRSLNVALRQELDLYVCLRPVRYYQGTPSPvkHPELtDMVIFRENSEDIYAGIEwkadsadAEKVikflreeMGVKKir 189
Cdd:TIGR00175 77 GHRSLNVALRKELDLYANVVHCKSLPGFKTR--HEDV-DIVIIRENTEGEYSGLE-------HESV-------PGVVE-- 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 190 fpehcgiGIKPCSEDGTKRLVRAAIEYAITNDRDSVTLVHKGNIMKFTEGAFKDWGYQLAKEEfggelidggpwqkiknp 269
Cdd:TIGR00175 138 -------SLKVITRDKSERIARYAFEYARKNGRKKVTAVHKANIMKLADGLFLNVCREVAKEY----------------- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 270 ntgKEIIIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFE-ATHGTAPKYAGQ 348
Cdd:TIGR00175 194 ---PDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVGGPGLVPGANIGRDYAVFEpGVRHTGPDIAGQ 270
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 695731456 349 DKVNPGSIILSAEMMLRHMEWFEAADLIVKGMEGAI-NAKTVTYDFerlmegAKLLKCSEFGDAIIANM 416
Cdd:TIGR00175 271 NIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIaEGKNRTKDL------GGTATTSDFTEAVIKRL 333
|
|
| PRK14025 |
PRK14025 |
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional |
29-413 |
1.15e-59 |
|
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
Pssm-ID: 184462 Cd Length: 330 Bit Score: 197.28 E-value: 1.15e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 29 IPFIEGDGIGVDVTPAMLKVVdaaveKAYKGERKISWMEiyTGEKSTQVYGqdVWLPAETLDLIRDYRVAIKGPLTTPVG 108
Cdd:PRK14025 4 ICVIEGDGIGKEVVPAALHVL-----EATGLPFEFVYAE--AGDEVFEKTG--KALPEETIEAAKEADAVLFGAAGETAA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 109 GGIrslnVALRQELDLYVCLRPVRYYQGTPSpvKHPELtDMVIFRENSEDIYAGIEWKADS--ADAEKVIkflreemgvk 186
Cdd:PRK14025 75 DVI----VKLRRILDTYANVRPVKSYKGVKC--LYPDI-DYVIVRENTEGLYKGIEAEIADgvTVATRVI---------- 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 187 kirfpehcgigikpcSEDGTKRLVRAAIEYA----ITNDRDSVTLVHKGNIMKFTEGAFKDWGYQLAKEEfggelidggp 262
Cdd:PRK14025 138 ---------------TRKASERIFRFAFEMAkrrkKMGKEGKVTCAHKANVLKKTDGLFKKTFYEVAKEY---------- 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 263 wqkiknpntgKEIIIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTA 342
Cdd:PRK14025 193 ----------PDIKAEDYYVDAMNMYIITRPQTFDVVVTSNLFGDILSDGAAGLVGGLGLAPSANIGDKYGLFEPVHGSA 262
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 695731456 343 PKYAGQDKVNPGSIILSAEMMLRHMEWFEAADLIVKGMEGAINAKTVTYDFerlmeGAKlLKCSEFGDAII 413
Cdd:PRK14025 263 PDIAGKGIANPTATILTAVLMLRHLGENEEADKVEKALEEVLALGLTTPDL-----GGN-LSTMEMAEEVA 327
|
|
| PLN00118 |
PLN00118 |
isocitrate dehydrogenase (NAD+) |
34-416 |
7.84e-56 |
|
isocitrate dehydrogenase (NAD+)
Pssm-ID: 215062 Cd Length: 372 Bit Score: 188.55 E-value: 7.84e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 34 GDGIGVDVTPAMLKVVDAAvekaykgERKISWMEIYTGEKSTQVYGQdvWLPAETLDLIRDYRVAIKGPLTTPVGGGIRS 113
Cdd:PLN00118 49 GDGIGPEIAESVKQVFTAA-------GVPIEWEEHYVGTTVDPRTGS--FLTWESLESVRRNKVGLKGPMATPIGKGHRS 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 114 LNVALRQELDLYVCLRPVRYYQGTPSPVKHpelTDMVIFRENSEDIYAGIEwkadsadaEKVIKFLREEmgvkkirfpeh 193
Cdd:PLN00118 120 LNLTLRKELGLYANVRPCYSLPGYKTRYDD---VDLVTIRENTEGEYSGLE--------HQVVRGVVES----------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 194 cgigIKPCSEDGTKRLVRAAIEYAITNDRDSVTLVHKGNIMKFTEGAFKDWGYQLAKeefggelidggpwqkiKNPntgk 273
Cdd:PLN00118 178 ----LKIITRQASLRVAEYAFHYAKTHGRKRVSAIHKANIMKKTDGLFLKCCREVAE----------------KYP---- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 274 EIIIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDE-CALFEATHGTAPKYAGQDKVN 352
Cdd:PLN00118 234 EIVYEEVIIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLIGGLGLTPSCNIGENgLALAEAVHGSAPDIAGKNLAN 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 695731456 353 PGSIILSAEMMLRHMEWFEAADLIVKGMEGAI-NAKTVTYDFerlmeGAKlLKCSEFGDAIIANM 416
Cdd:PLN00118 314 PTALLLSAVMMLRHLKLNEQAEQIHNAILNTIaEGKYRTADL-----GGS-STTTDFTKAICDHL 372
|
|
| PLN00123 |
PLN00123 |
isocitrate dehydrogenase (NAD+) |
28-416 |
3.53e-54 |
|
isocitrate dehydrogenase (NAD+)
Pssm-ID: 215065 Cd Length: 360 Bit Score: 183.91 E-value: 3.53e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 28 IIPFIEGDGIGVDVTPAMLKVVDAAVEKAYkgerkiswMEIYtgekstQVYGQDVWLPAETLDLIRDYRVAIKGPLTTPV 107
Cdd:PLN00123 32 AVTLIPGDGIGPLVTGAVEQVMEAMHAPVY--------FERY------EVHGDMKKVPEEVLESIRRNKVCLKGGLATPV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 108 GGGIRSLNVALRQELDLYVCLrpVRYYQGTPSPVKHPELtDMVIFRENSEDIYAGIEwkadsadaEKVIKFLREEMGVKK 187
Cdd:PLN00123 98 GGGVSSLNVQLRKELDLFASL--VNCFNLPGLPTRHENV-DIVVIRENTEGEYSGLE--------HEVVPGVVESLKVIT 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 188 irfpehcgigiKPCSEdgtkRLVRAAIEYAITNDRDSVTLVHKGNIMKFTEGAFKDWGYQLAKeefggelidggpwqkiK 267
Cdd:PLN00123 167 -----------KFCSE----RIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAK----------------K 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 268 NPNtgkeIIIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFE--ATHGTA--P 343
Cdd:PLN00123 216 YPG----IKYNEIIVDNCCMQLVSKPEQFDVMVTPNLYGNLVANTAAGIAGGTGVMPGGNVGADHAVFEqgASAGNVgnE 291
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695731456 344 KYAGQDKVNPGSIILSAEMMLRHMEWFEAADLIVKGMEGAI-NAKTVTYDferlMEGAKLLKcsEFGDAIIANM 416
Cdd:PLN00123 292 KLVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIaEGKYRTKD----LGGSSTTQ--EVVDAVIANL 359
|
|
| PRK03437 |
PRK03437 |
3-isopropylmalate dehydrogenase; Provisional |
32-416 |
1.24e-50 |
|
3-isopropylmalate dehydrogenase; Provisional
Pssm-ID: 179579 Cd Length: 344 Bit Score: 173.96 E-value: 1.24e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 32 IEGDGIGVDVTPAMLKVVDAAVEKAYK---------GERkisWMEiyTGEKstqvygqdvwLPAETLDLIRDYRVAIKGP 102
Cdd:PRK03437 10 IPGDGIGPEVVAEALKVLDAVAAGGPGvetteydlgARR---YLR--TGET----------LPDSVLAELRQHDAILLGA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 103 LTTP-VGGGI--RSLNVALRQELDLYVCLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEwkadsadaekvikfl 179
Cdd:PRK03437 75 IGDPsVPSGVleRGLLLKLRFALDHYVNLRPSKLYPGVTSPLAGPGDIDFVVVREGTEGPYTGNG--------------- 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 180 reemGVKKIRFPEHCGIGIKPCSEDGTKRLVRAAIEYAITNDRDSVTLVHKGNIMKFtegafkdwgyqlakeefGGELid 259
Cdd:PRK03437 140 ----GALRVGTPHEVATEVSVNTAFGVERVVRDAFERAQKRPRKHLTLVHKTNVLTF-----------------AGDL-- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 260 ggpWQKIKNpNTGKEIiiKDVIA-----DAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANI---GDE 331
Cdd:PRK03437 197 ---WQRTVD-EVAAEY--PDVTVdyqhvDAATIFMVTDPSRFDVIVTDNLFGDIITDLAAAVTGGIGLAASGNInptGTN 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 332 CALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMEWFEAADLIvkgmEGAINAKTVtydfERLMEGaklLKCSEFGDA 411
Cdd:PRK03437 271 PSMFEPVHGSAPDIAGQGIADPTAAILSVALLLDHLGEEDAAARI----EAAVEADLA----ERGKMG---RSTAEVGDR 339
|
....*
gi 695731456 412 IIANM 416
Cdd:PRK03437 340 IAARL 344
|
|
| PRK00772 |
PRK00772 |
3-isopropylmalate dehydrogenase; Provisional |
32-416 |
1.39e-43 |
|
3-isopropylmalate dehydrogenase; Provisional
Pssm-ID: 234832 Cd Length: 358 Bit Score: 155.64 E-value: 1.39e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 32 IEGDGIGVDVTPAMLKVVDAAvekAYKGERKISWMEIYTGEKSTQVYGqdVWLPAETLDLIR--DyrvAIkgpLTTPVGG 109
Cdd:PRK00772 8 LPGDGIGPEVMAEAVKVLDAV---AEKFGFDFEFEEALVGGAAIDAHG--VPLPEETLEACRaaD---AV---LLGAVGG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 110 --------------GIrslnVALRQELDLYVCLRPVRYYQG--TPSPVKhPEL---TDMVIFRENSEDIYAGiewkadsa 170
Cdd:PRK00772 77 pkwdnlppdvrperGL----LALRKELGLFANLRPAKLYPGlaDASPLK-PEIvagLDILIVRELTGGIYFG-------- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 171 DAEKVIKFLREEMGVKKIRFpehcgigikpcSEDGTKRLVRAAIEYAitNDRDS-VTLVHKGNIMKftegafkdwgyqla 249
Cdd:PRK00772 144 EPRGREGLGGEERAFDTMVY-----------TREEIERIARVAFELA--RKRRKkVTSVDKANVLE-------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 250 keefGGELidggpWQKIKNpNTGKEIiiKDV-----IADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324
Cdd:PRK00772 197 ----SSRL-----WREVVT-EVAKEY--PDVelshmYVDNAAMQLVRNPKQFDVIVTENLFGDILSDEAAMLTGSLGMLP 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 325 GANIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH---MEwfEAADLIVKGMEGAINAKTVTYDferLMEGA 400
Cdd:PRK00772 265 SASLGESGpGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYslgLE--EAADAIEAAVEKVLAQGYRTAD---IAEGG 339
|
410
....*....|....*.
gi 695731456 401 KLLKCSEFGDAIIANM 416
Cdd:PRK00772 340 GKVSTSEMGDAILAAL 355
|
|
| PRK08194 |
PRK08194 |
tartrate dehydrogenase; Provisional |
29-392 |
5.17e-36 |
|
tartrate dehydrogenase; Provisional
Pssm-ID: 181281 Cd Length: 352 Bit Score: 135.23 E-value: 5.17e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 29 IPFIEGDGIGVDVTPAMLKVVDAAVEkaYKGERKISWMEIYTGEKSTQVYGQdvWLPAETLDLIRDYRV----AIKGPLT 104
Cdd:PRK08194 6 IAVIPGDGVGKEVVPAAVRVLKAVAE--VHGGLKFEFTEFPWSCEYYLEHGE--MMPEDGLEQLKQFDAiflgAVGNPKL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 105 TPVGGGIRSLNVALRQELDLYVCLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAgiewkadsadaekvikflreEMG 184
Cdd:PRK08194 82 VPDHISLWGLLIKIRREFEQVINIRPAKQLRGIKSPLANPKDFDLLVVRENSEGEYS--------------------EVG 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 185 VKKIRFPEHCGIGIKPCSEDGTKRLVRAAIEYAiTNDRDSVTLVHKGN----IMKFTEGAFKDWGyqlakEEFggelidg 260
Cdd:PRK08194 142 GRIHRGEDEIAIQNAVFTRKGTERAMRYAFELA-AKRRKHVTSATKSNgivhSMPFWDEVFQEVG-----KDY------- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 261 gpwqkiknpntgKEIIIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANI---GDECALFEA 337
Cdd:PRK08194 209 ------------PEIETDSQHIDALAAFFVTRPEEFDVIVASNLFGDILTDIGAAIMGSIGIAPAANInvnGKYPSMFEP 276
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 695731456 338 THGTAPKYAGQDKVNPGSIILSAEMMLRHMEWFEAADLIVKGMEGAINAKTVTYD 392
Cdd:PRK08194 277 VHGSAPDIAGKGIANPIGQIWTAKLMLDHFGEEELGSHLLDVIEDVTEDGIKTPD 331
|
|
| PLN02329 |
PLN02329 |
3-isopropylmalate dehydrogenase |
1-416 |
5.18e-16 |
|
3-isopropylmalate dehydrogenase
Pssm-ID: 215188 Cd Length: 409 Bit Score: 79.35 E-value: 5.18e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 1 MESKVVVPaeGKKITLQNGKINVPH-------NPI-----IPFIEGDGIGvdvtPAMLKVVDAAVEKA-YKGERKISWME 67
Cdd:PLN02329 11 LNSIKIVP--GRYSSLTDHQFRAPYrircaaaSPGkkrynIALLPGDGIG----PEVISVAKNVLQKAgSLEGLEFDFQE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 68 IYTGEKSTQVYGqdVWLPAETLDLIRDYRVAIKGPlttpVGGGIRSLN----------VALRQELDLYVCLRPV----RY 133
Cdd:PLN02329 85 MPVGGAALDLVG--VPLPEETFTAAKQSDAILLGA----IGGYKWDKNekhlrpemalFYLRRDLKVFANLRPAtvlpQL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 134 YQGTPSPVKHPELTDMVIFRENSEDIYAGiewkadsadaekvikflrEEMGVKKIRFPEHCGIGIKPCSEDGTKRLVRAA 213
Cdd:PLN02329 159 VDASTLKKEVAEGVDMMIVRELTGGIYFG------------------EPRGITINENGEEVGVSTEIYAAHEIDRIARVA 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 214 IEYAiTNDRDSVTLVHKGNIMKfTEGAFKDWGYQLAKEEfggelidggpwqkiknpntgKEIIIKDVIADAFLQQILLRP 293
Cdd:PLN02329 221 FETA-RKRRGKLCSVDKANVLD-ASILWRKRVTALASEY--------------------PDVELSHMYVDNAAMQLIRDP 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695731456 294 AEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDEC-ALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH-MEWFE 371
Cdd:PLN02329 279 KQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGpGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEK 358
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 695731456 372 AADLIVKGMEGAINAKTVTYDFerLMEGAKLLKCSEFGDAIIANM 416
Cdd:PLN02329 359 AAKRIEDAVVDALNKGFRTGDI--YSPGNKLVGCKEMGEEVLKSV 401
|
|
| |
