|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09263 |
PRK09263 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
1-711 |
0e+00 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 236436 [Multi-domain] Cd Length: 711 Bit Score: 1491.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 1 MTPHVMKRDGCKVPFKSERIQEAILRAAKAAGVDDADYCATVAEVVSSQMNERSQVDISEIQTAVENQLMAGPYKQLARA 80
Cdd:PRK09263 1 MMPKVIKRDGRKVPFDSEKIKNAIEKAAKAVEVDDEDYCATVAAEIASRVEGRDEVDIEEIQDAVENQLMAGPYKALARA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 81 YIEYRHDRDVQREKRGRLNQEIRGLVEQTNSALLNENANKDSKVIPTQRDLLAGIVAKHYARQHLLPRDVVSAHERGEIH 160
Cdd:PRK09263 81 YIEYRHDRDIAREKATDLNEEIRGLIEQSNEAVLNENANKDSKVFSTQRDLLAGIVSKHYALRHLLPRDVVNAHEKGDIH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 161 YHDLDYSPFFPMFNCMLIDLKGMLTHGFKMGNAEIEPPKSISTATAVTAQIIAQVASHIYGGTTINRIDEVLAPFVTASF 240
Cdd:PRK09263 161 YHDLDYSPFFPMFNCCLIDLKGMLTNGFKIGNAEIESPKSIQTATAVTAQIIAQVASSQYGGCTINRIDEVLAPYAEKSY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 241 NKHRKTAEEWQI-PDADGYAHSRTEKECYDAFQSLEYEVNTLHTANGQTPFVTFGFGLGTSWESRLIQQSILRNRISGLG 319
Cdd:PRK09263 241 EKHLKDAEEWVIeEKAEAYARARTEKEIYDAMQSLEYEINTLHTSNGQTPFVTLGFGLGTSWESRLIQKAILRNRIAGLG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 320 KNRKTAVFPKLVFAIRDGLNHKFGDPNYDIKQLALECASKRMYPDILNYDQVVKVTGSFKTPMGCRSFLGVYEDENGEQI 399
Cdd:PRK09263 321 KERKTAIFPKLVFAIKDGLNLKPGDPNYDIKQLALECATKRMYPDILNYDKIVELTGSFKTPMGCRSFLQGWKDENGEEV 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 400 HDGRNNLGVISLNLPRIALEAKGNEAEFWTLLDERLQLARKALMTRIARLEGVKARVAPILYMEGACGVRLKADDDVSEI 479
Cdd:PRK09263 401 HDGRNNLGVVTLNLPRIALEAKGDEDKFWEILDERLELAKKALMTRIERLKGAKPRVAPILYMYGAFGVRLKADDDVDEL 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 480 FKNGRASISLGYIGIHETINALAGDTHMYDSEAlREKGIAIVQRLRDAVDQWKEETGYGFSLYSTPSENLCDRFCRLDTA 559
Cdd:PRK09263 481 FKNGRATISLGYIGLYETINALYGGSWEVNPEA-KAFALAIVKRMKDACDQWKKETGYGFSLYSTPSESLTDRFCRLDTE 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 560 EFGIVEGVTDKGYYTNSFHLDVEKKVNPYDKIDFEAAYPPIASGGFICYGEYPNIQHNLKALEDVWDYSYQHVPYYGTNT 639
Cdd:PRK09263 560 KFGVIPGITDKGYYTNSFHYDVRKKVNPFEKLDFEKPYPPLASGGFIHYCEYPNLQHNLKALEAVWDYSYDRVGYLGTNT 639
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 695736012 640 PIDECYECGFTGEFECTSKGFTCPKCGNHDAARVSVTRRVCGYLGSPDARPFNAGKQEEVKRRVKHLGNGQI 711
Cdd:PRK09263 640 PIDECYECGFTGEFECTEKGFTCPKCGNHDPKTVSVTRRTCGYLGNPDARPFNHGRQEEIKRRVKHMSGGQI 711
|
|
| NrdD |
COG1328 |
Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; ... |
1-695 |
0e+00 |
|
Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; Anaerobic ribonucleoside-triphosphate reductase is part of the Pathway/BioSystem: Thymidylate biosynthesis
Pssm-ID: 440939 [Multi-domain] Cd Length: 671 Bit Score: 901.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 1 MTPHVMKRDGCKVPFKSERIQEAILRAAKAAGVDDAD--YCATVA-EVVS--SQMNERSQVDISEIQTAVENQLMAGPYK 75
Cdd:COG1328 1 MMLKVIKRDGRVVPFDPEKIANAIKKAAKAVGGEDRDeeLAEEIAdEVEKelERLGGGGTITVEEIQDIVEKVLMESGHP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 76 QLARAYIEYRHDRDVQREKRGRLNQEIRGLVEQtNSALLNENANKdSKVIPTQRDLLAGIVAKHYARQHLLPRDVVSAHE 155
Cdd:COG1328 81 EVAKAYILYREQRTRLREARTTLVDDIELLDEY-DDWRVNENANK-SYSFSTQRDLIAGEVSKEYALNKILPPEVADAHR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 156 RGEIHYHDLDYSPFfpMFNCMLIDLKGMLTHGFKMGNAEIEPPKSISTATAVTAQIIAQVASHIYGGTTINRIDEVLAPF 235
Cdd:COG1328 159 NGDIHIHDLDYLPR--MTNCCLWDLRDLLKNGFNGGNGKVEPPKHIQTALAQMAQIIATVQSEQAGGQAFSRFDTYLAPY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 236 VtasfnkhRKTAEEwqipdadgyahSRTEKECYDAFQSLEYEVNTLHTANGQTPFVTFGFGLGT----SWESRLIQQSIL 311
Cdd:COG1328 237 V-------RKDKLE-----------GKTYKEIKQAMQSLEYNLNTLPSRRGQTPFTSITFGLGTpedfSWEMRMINKAIL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 312 RNRISGLGkNRKTAVFPKLVFAIRDGLNHKFGDPNYDIKQLALECASKRMYPDILNYDQVVKV-TGSFKTPMGCRSFLGV 390
Cdd:COG1328 299 EVRIEGDG-EGRTFIFPKLIFNITEGFNWEPEDPNYDLLQLAFECTAKRGYPYFLNYDNSDELyKGSFKRSMGCRLFLDG 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 391 YEdeNGEQIHDGRNNLGVISLNLPRIALEAKGNEAEFWTLLDERLQLARKALMTRIARLEG-VKARVAPILYMEGACGVR 469
Cdd:COG1328 378 WE--NGEELNRGRGNLGVVTLNLPRIAYEAKGDEEKFFEILDERLDLAKEALEIKRKRLQKlAKAGLAPILYQTGAYLGR 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 470 LKADDDVSEIFKNGRASIslGYIGIHETINALAGDTHMYDSEAlREKGIAIVQRLRDAVDQWKEETGYGFSLYSTPSENL 549
Cdd:COG1328 456 LKPDDSIDELFKNGFSTI--GYIGLNEMLLNFTGKHHIESEEA-KAFALEILKHMRERADEWQEETGYLYSLYATPAESL 532
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 550 CDRFCRLDTAEFGIVEGVTDKGYYTNSFHLDVEKKVNPYDKIDFEAAYPPIASGGFICYGEYPNIQHNLKALEDVWDYSY 629
Cdd:COG1328 533 TYRFAKLDKKRFGDIIGVTDKPYYTNSFHLPVRKTIDPFEKLDFEDEYQPLYTGGTISYVELGELQPNPEALEAVVRYAY 612
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 695736012 630 Q--HVPYYGTNTPIDECYECGFTGEFECtskgfTCPKCGNHDaaRVSVTRRVCGYLGSPDarPFNAGK 695
Cdd:COG1328 613 DnyRIGYLGINPPFDICPKCGYLGGEHD-----ECPKCGNED--TVEVIRRTCGYLGNVQ--PWNDGK 671
|
|
| NrdD |
TIGR02487 |
anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive ... |
115-705 |
0e+00 |
|
anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive (anaerobic, class III) ribonucleotide reductase. The mechanism of the enzyme involves a glycine-centered radical, a C-terminal zinc binding site, and a set of conserved active site cysteines and asparagines. This enzyme requires an activating component, NrdG, a radical-SAM domain containing enzyme (TIGR02491). Together the two form an alpha-2/beta-2 heterodimer. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274159 [Multi-domain] Cd Length: 579 Bit Score: 759.95 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 115 NENANKDSKVIPTQRDLLAGIVAKHYARQHLLPRDVVSAHERGEIHYHDLDYsPFFPMFNCMLIDLKGMLTHGFKMGNAE 194
Cdd:TIGR02487 1 NENANMDSPTPSTQRKLIASEVSKDYALLHLLPKDIARAHLNGDIHIHDLDY-ALTLTTNCCLHDLRNLLKYGFRTGNIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 195 IEPPKSISTATAVTAQIIAQVASHIYGGTTINRIDEVLAPFVTASFNKHRKTAEEWQ--IPDADGYAHSRTEKECYDAFQ 272
Cdd:TIGR02487 80 SKPPKHIDVALNHIVNILQSLQNEQYGGQSFPEFDTLLAPYIEKTNLKHRKVLQQLQllLFEATEYAARRTFTDVTQAMQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 273 SLEYEVNTLHTANGQTPFVTFGFGLGTSWESRLIQQSILRNRISGLGKnRKTAVFPKLVFAIRDGLNHKFGDPnYDIKQL 352
Cdd:TIGR02487 160 GPEYNPNTLHSAGGQTPFESIGYGTETSKEGRMIAKALLDVRMEGDGK-GEPFIFPKIIFKVREGFNWDEPDP-YDLFEL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 353 ALECASKRMYPDILNYDQVVKVTGSFKTPMGCRSFLGVYEDENGEQIHDGRNNLGVISLNLPRIALEAKGNEAEFWTLLD 432
Cdd:TIGR02487 238 AFECAAKRGYPYFLNLDPEDNVKEDVRYPMGCRTFLSPNENGDGEESYIGRGNIGVTSINLPRIAYKSRGDEEEFFEELD 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 433 ERLQLARKALMTRIARLEGVKARVAPILYMEGA-CGVRLKaDDDVSEIFKNGraSISLGYIGIHETINALAGDTHmYDSE 511
Cdd:TIGR02487 318 EYLEIAKEALEIRREYLKKMLAKDLPPMYSQGGwDGGNLL-DESVEEILKSG--TNSIGFIGLNEALVALTGKHL-HEEE 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 512 ALREKGIAIVQRLRDAVDQWKEETGYGFSLYSTPSENLCDRFCRLDTAEFGIVEGVTDKGYYTNSFHLDVEKKVNPYDKI 591
Cdd:TIGR02487 394 EARELAIRILEFIRDKADEFKKETGLNYSVYATPAESLCGRFAKKDREEFGEIPGVTDKPYYTNSFHVPVYEDVNLGEKI 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 592 DFEAAYPPIASGGFICYGEYPNIQHNLKALEDVWDYSYQH-VPYYGTNTPIDECYECGFTGEFECtskgFTCPKCGNHDa 670
Cdd:TIGR02487 474 DIEAPFHPLTNGGHITYIELDEAIPDPEALKDITKKAMKNgIGYFGINPPVDVCEDCGYTGEGLN----DKCPKCGSHD- 548
|
570 580 590
....*....|....*....|....*....|....*
gi 695736012 671 arVSVTRRVCGYLGspDARPFNAGKQEEVKRRVKH 705
Cdd:TIGR02487 549 --IEVISRITGYLG--PVENWNDGKQAEFKDRKKH 579
|
|
| NRDD |
pfam13597 |
Anaerobic ribonucleoside-triphosphate reductase; |
117-705 |
0e+00 |
|
Anaerobic ribonucleoside-triphosphate reductase;
Pssm-ID: 463930 [Multi-domain] Cd Length: 554 Bit Score: 732.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 117 NANKDSKVIPTQRDLLAGIVAKHYARQHLLPRDVVSAHERGEIHYHDLDYSPFFpMFNCMLIDLKGMLTHGFKMGNAEIE 196
Cdd:pfam13597 1 NANKDSYSPSGQRLYIAGEVSKDYALRKLLPPEIADAHEEGDIHIHDLDYYALR-TPYCCGIDLRDLLENGFVTGNGVSR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 197 PPKSISTATAVTAQIIAQVASHIYGGTTINRIDEVLAPFVTASFNKHRKTaeewqipdadgyahsRTEKECYDAFQSLEY 276
Cdd:pfam13597 80 PPKHIETACAQAVNILATVQNEQAGGQAFSSFDTYLAPFVRKDYEKHLKG---------------LTYKEVKQAMQAFVY 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 277 EVNTLHTANG-QTPFVTFGFGLGTSWESR----LIQQSILRNRISGLGKNRKTAVFPKLVFAIRDGLNHKFGDPNYDIKQ 351
Cdd:pfam13597 145 NLNTMPSRRGgQTPFTNINLGLDTPKEGRdemdMIIKALLEVMLEGDGNGGTPFTFPIPIYKLKEGFNWDEGDPNYDLFE 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 352 LALECASKRMYPDILNYDQVVKVTGSFKTPMGCRSFLGVYEDENgeqIHDG-RNNLGVISLNLPRIALEAKGNEAEFWTL 430
Cdd:pfam13597 225 LAFECTAKRGYPYFSNFDSDLLPGDGYVASMGCRLRLDLRPNRK---RFGGlRGNIGVVTINLPRIAYEAAGDEDKFFEL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 431 LDERLQLARKALMTRIARLEGVKARV-APILYMEGAcgvrlkadddvseiFKNGRASISLGYIGIHETINALAGDTHMYD 509
Cdd:pfam13597 302 LDERLELAKEALLIRREVLKKLLAKGlLPFLMGEGY--------------LRGGNHTLTIGFIGLNEALKALTGKHHGES 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 510 SEAlREKGIAIVQRLRDAVDQWKEETGYGFSLYSTPSENLCDRFCRLDTAEFGIVEGVTDKGYYTNSFHLDVEKKVNPYD 589
Cdd:pfam13597 368 EEA-KEFALKILKHMREKADEWKEETGLNFSLEATPAESLSYRFAKLDKKRFGEIKGVTDKPYYTNSFHVPVDYTIDAFE 446
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 590 KIDFEAAYPPIASGGFICYGEYPNIQHNLKALEDVWDYSYQ-HVPYYGTNTPIDECYECGFTGEFEctskgfTCPKCGNH 668
Cdd:pfam13597 447 KLKLEAPFQPLTTGGHISHVELGEAQPNPEALEKLVRIAYDtGIGYFSINPPIDVCPDCGYTGEIE------ECPNCGNH 520
|
570 580 590
....*....|....*....|....*....|....*..
gi 695736012 669 DaARVSVTRRVCGYLGSPDArpFNAGKQEEVKRRVKH 705
Cdd:pfam13597 521 D-EKVEVIRRITGYLRPVSD--WNKGKQAELKDRVKH 554
|
|
| RNR_III |
cd01675 |
Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
116-685 |
0e+00 |
|
Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in strict or facultative anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). The class III enzyme from phage T4 consists of two subunits, this model covers the larger subunit which contains the active and allosteric sites.
Pssm-ID: 153084 [Multi-domain] Cd Length: 555 Bit Score: 682.87 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 116 ENANKDSKVIPTQRDLLAGIVAKHYARqHLLPRDVVSAHERGEIHYHDLDYSPffPMFNCMLIDLKGMLTHGFKMGNAEI 195
Cdd:cd01675 1 ENANVDSSPGSTMKDLAAGIVKKYYLL-KILPKEIARAHLNGDIHIHDLDYLP--LTPYCCGWDLRPLLEKGFTTGNGII 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 196 EPPKSISTATAVTAQIIAQVASHIYGGTTINRIDEVLAPFVTASFNKHRKTAeewqipdadgyahsrTEKECYDAFQSLE 275
Cdd:cd01675 78 EPPKHLSSALGHIVNFLGTVQNEQAGGQAFPEFDTYLAPFVRKDYLKYRLTA---------------TRKEIKQAMQGFI 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 276 YEVNTLHTANGQTPFVTFGFGL-------------------GTSWESRLIQQSILRNRISGLGKnRKTAVFPKLVFAIRD 336
Cdd:cd01675 143 YNLNTLSRRGGQTPFTNITLGLvcpkdlefegggepvftygDTDKEARMIQKAFLEVRLEGDAK-GRPFTFPIPTFNVTE 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 337 GLNHkfgDPNYDIKQLALECASKRMYPDILNYDQVVKVTGSfKTPMGCRSFLGVYE---DENGEQIHDGRNNLGVISLNL 413
Cdd:cd01675 222 GFNL---DPNYDLKELAFECAAKRGYPYFLNFDNSDNVPGD-VRAMGCRLFLDKNElkrGGGLEGSGDGTGNIGVVTINL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 414 PRIALEAKGNEAEFWTLLDERLQLARKALMTRIARLEGVKARVAPILYMEGACGVRLKadddvseiFKNGRASISLGYIG 493
Cdd:cd01675 298 PRIAYEARGDEEKFFELLDEYLELAKDALEIRRKRLKEALARGLPPLYQEGLGGGKLL--------FILKRHTLTIGFIG 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 494 IHETINALAGDTHmYDSEALREKGIAIVQRLRDAVDQWKEETGYGFSLYSTPSENLCDRFCRLDTAEFG-IVEGVTDKGY 572
Cdd:cd01675 370 LNEAAEALTGKGI-GESEEAREFGIRILEHIRERADEFKEETGLLYSVEATPAESLAYRFAKKDRKKYGdIIPGVTDKPY 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 573 YTNSFHLDVEKKVNPYDKIDFEAAYPPIASGGFICYGEYPNIQHNLKALEDVWDYSYQH-VPYYGTNTPIDECYECGFTG 651
Cdd:cd01675 449 YTNSFHVPVYEDIDPFEKIDIEAKLHPLTTGGHILHIELGEAKPNPEALEALVKKAAKRgVIYFGINTPIDICNDCGYIG 528
|
570 580 590
....*....|....*....|....*....|....
gi 695736012 652 EFEctskGFTCPKCGNHDaarVSVTRRVCGYLGS 685
Cdd:cd01675 529 EGE----GFKCPKCGSED---VEVISRITGYLGP 555
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09263 |
PRK09263 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
1-711 |
0e+00 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 236436 [Multi-domain] Cd Length: 711 Bit Score: 1491.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 1 MTPHVMKRDGCKVPFKSERIQEAILRAAKAAGVDDADYCATVAEVVSSQMNERSQVDISEIQTAVENQLMAGPYKQLARA 80
Cdd:PRK09263 1 MMPKVIKRDGRKVPFDSEKIKNAIEKAAKAVEVDDEDYCATVAAEIASRVEGRDEVDIEEIQDAVENQLMAGPYKALARA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 81 YIEYRHDRDVQREKRGRLNQEIRGLVEQTNSALLNENANKDSKVIPTQRDLLAGIVAKHYARQHLLPRDVVSAHERGEIH 160
Cdd:PRK09263 81 YIEYRHDRDIAREKATDLNEEIRGLIEQSNEAVLNENANKDSKVFSTQRDLLAGIVSKHYALRHLLPRDVVNAHEKGDIH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 161 YHDLDYSPFFPMFNCMLIDLKGMLTHGFKMGNAEIEPPKSISTATAVTAQIIAQVASHIYGGTTINRIDEVLAPFVTASF 240
Cdd:PRK09263 161 YHDLDYSPFFPMFNCCLIDLKGMLTNGFKIGNAEIESPKSIQTATAVTAQIIAQVASSQYGGCTINRIDEVLAPYAEKSY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 241 NKHRKTAEEWQI-PDADGYAHSRTEKECYDAFQSLEYEVNTLHTANGQTPFVTFGFGLGTSWESRLIQQSILRNRISGLG 319
Cdd:PRK09263 241 EKHLKDAEEWVIeEKAEAYARARTEKEIYDAMQSLEYEINTLHTSNGQTPFVTLGFGLGTSWESRLIQKAILRNRIAGLG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 320 KNRKTAVFPKLVFAIRDGLNHKFGDPNYDIKQLALECASKRMYPDILNYDQVVKVTGSFKTPMGCRSFLGVYEDENGEQI 399
Cdd:PRK09263 321 KERKTAIFPKLVFAIKDGLNLKPGDPNYDIKQLALECATKRMYPDILNYDKIVELTGSFKTPMGCRSFLQGWKDENGEEV 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 400 HDGRNNLGVISLNLPRIALEAKGNEAEFWTLLDERLQLARKALMTRIARLEGVKARVAPILYMEGACGVRLKADDDVSEI 479
Cdd:PRK09263 401 HDGRNNLGVVTLNLPRIALEAKGDEDKFWEILDERLELAKKALMTRIERLKGAKPRVAPILYMYGAFGVRLKADDDVDEL 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 480 FKNGRASISLGYIGIHETINALAGDTHMYDSEAlREKGIAIVQRLRDAVDQWKEETGYGFSLYSTPSENLCDRFCRLDTA 559
Cdd:PRK09263 481 FKNGRATISLGYIGLYETINALYGGSWEVNPEA-KAFALAIVKRMKDACDQWKKETGYGFSLYSTPSESLTDRFCRLDTE 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 560 EFGIVEGVTDKGYYTNSFHLDVEKKVNPYDKIDFEAAYPPIASGGFICYGEYPNIQHNLKALEDVWDYSYQHVPYYGTNT 639
Cdd:PRK09263 560 KFGVIPGITDKGYYTNSFHYDVRKKVNPFEKLDFEKPYPPLASGGFIHYCEYPNLQHNLKALEAVWDYSYDRVGYLGTNT 639
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 695736012 640 PIDECYECGFTGEFECTSKGFTCPKCGNHDAARVSVTRRVCGYLGSPDARPFNAGKQEEVKRRVKHLGNGQI 711
Cdd:PRK09263 640 PIDECYECGFTGEFECTEKGFTCPKCGNHDPKTVSVTRRTCGYLGNPDARPFNHGRQEEIKRRVKHMSGGQI 711
|
|
| NrdD |
COG1328 |
Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; ... |
1-695 |
0e+00 |
|
Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; Anaerobic ribonucleoside-triphosphate reductase is part of the Pathway/BioSystem: Thymidylate biosynthesis
Pssm-ID: 440939 [Multi-domain] Cd Length: 671 Bit Score: 901.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 1 MTPHVMKRDGCKVPFKSERIQEAILRAAKAAGVDDAD--YCATVA-EVVS--SQMNERSQVDISEIQTAVENQLMAGPYK 75
Cdd:COG1328 1 MMLKVIKRDGRVVPFDPEKIANAIKKAAKAVGGEDRDeeLAEEIAdEVEKelERLGGGGTITVEEIQDIVEKVLMESGHP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 76 QLARAYIEYRHDRDVQREKRGRLNQEIRGLVEQtNSALLNENANKdSKVIPTQRDLLAGIVAKHYARQHLLPRDVVSAHE 155
Cdd:COG1328 81 EVAKAYILYREQRTRLREARTTLVDDIELLDEY-DDWRVNENANK-SYSFSTQRDLIAGEVSKEYALNKILPPEVADAHR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 156 RGEIHYHDLDYSPFfpMFNCMLIDLKGMLTHGFKMGNAEIEPPKSISTATAVTAQIIAQVASHIYGGTTINRIDEVLAPF 235
Cdd:COG1328 159 NGDIHIHDLDYLPR--MTNCCLWDLRDLLKNGFNGGNGKVEPPKHIQTALAQMAQIIATVQSEQAGGQAFSRFDTYLAPY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 236 VtasfnkhRKTAEEwqipdadgyahSRTEKECYDAFQSLEYEVNTLHTANGQTPFVTFGFGLGT----SWESRLIQQSIL 311
Cdd:COG1328 237 V-------RKDKLE-----------GKTYKEIKQAMQSLEYNLNTLPSRRGQTPFTSITFGLGTpedfSWEMRMINKAIL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 312 RNRISGLGkNRKTAVFPKLVFAIRDGLNHKFGDPNYDIKQLALECASKRMYPDILNYDQVVKV-TGSFKTPMGCRSFLGV 390
Cdd:COG1328 299 EVRIEGDG-EGRTFIFPKLIFNITEGFNWEPEDPNYDLLQLAFECTAKRGYPYFLNYDNSDELyKGSFKRSMGCRLFLDG 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 391 YEdeNGEQIHDGRNNLGVISLNLPRIALEAKGNEAEFWTLLDERLQLARKALMTRIARLEG-VKARVAPILYMEGACGVR 469
Cdd:COG1328 378 WE--NGEELNRGRGNLGVVTLNLPRIAYEAKGDEEKFFEILDERLDLAKEALEIKRKRLQKlAKAGLAPILYQTGAYLGR 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 470 LKADDDVSEIFKNGRASIslGYIGIHETINALAGDTHMYDSEAlREKGIAIVQRLRDAVDQWKEETGYGFSLYSTPSENL 549
Cdd:COG1328 456 LKPDDSIDELFKNGFSTI--GYIGLNEMLLNFTGKHHIESEEA-KAFALEILKHMRERADEWQEETGYLYSLYATPAESL 532
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 550 CDRFCRLDTAEFGIVEGVTDKGYYTNSFHLDVEKKVNPYDKIDFEAAYPPIASGGFICYGEYPNIQHNLKALEDVWDYSY 629
Cdd:COG1328 533 TYRFAKLDKKRFGDIIGVTDKPYYTNSFHLPVRKTIDPFEKLDFEDEYQPLYTGGTISYVELGELQPNPEALEAVVRYAY 612
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 695736012 630 Q--HVPYYGTNTPIDECYECGFTGEFECtskgfTCPKCGNHDaaRVSVTRRVCGYLGSPDarPFNAGK 695
Cdd:COG1328 613 DnyRIGYLGINPPFDICPKCGYLGGEHD-----ECPKCGNED--TVEVIRRTCGYLGNVQ--PWNDGK 671
|
|
| NrdD |
TIGR02487 |
anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive ... |
115-705 |
0e+00 |
|
anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive (anaerobic, class III) ribonucleotide reductase. The mechanism of the enzyme involves a glycine-centered radical, a C-terminal zinc binding site, and a set of conserved active site cysteines and asparagines. This enzyme requires an activating component, NrdG, a radical-SAM domain containing enzyme (TIGR02491). Together the two form an alpha-2/beta-2 heterodimer. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274159 [Multi-domain] Cd Length: 579 Bit Score: 759.95 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 115 NENANKDSKVIPTQRDLLAGIVAKHYARQHLLPRDVVSAHERGEIHYHDLDYsPFFPMFNCMLIDLKGMLTHGFKMGNAE 194
Cdd:TIGR02487 1 NENANMDSPTPSTQRKLIASEVSKDYALLHLLPKDIARAHLNGDIHIHDLDY-ALTLTTNCCLHDLRNLLKYGFRTGNIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 195 IEPPKSISTATAVTAQIIAQVASHIYGGTTINRIDEVLAPFVTASFNKHRKTAEEWQ--IPDADGYAHSRTEKECYDAFQ 272
Cdd:TIGR02487 80 SKPPKHIDVALNHIVNILQSLQNEQYGGQSFPEFDTLLAPYIEKTNLKHRKVLQQLQllLFEATEYAARRTFTDVTQAMQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 273 SLEYEVNTLHTANGQTPFVTFGFGLGTSWESRLIQQSILRNRISGLGKnRKTAVFPKLVFAIRDGLNHKFGDPnYDIKQL 352
Cdd:TIGR02487 160 GPEYNPNTLHSAGGQTPFESIGYGTETSKEGRMIAKALLDVRMEGDGK-GEPFIFPKIIFKVREGFNWDEPDP-YDLFEL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 353 ALECASKRMYPDILNYDQVVKVTGSFKTPMGCRSFLGVYEDENGEQIHDGRNNLGVISLNLPRIALEAKGNEAEFWTLLD 432
Cdd:TIGR02487 238 AFECAAKRGYPYFLNLDPEDNVKEDVRYPMGCRTFLSPNENGDGEESYIGRGNIGVTSINLPRIAYKSRGDEEEFFEELD 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 433 ERLQLARKALMTRIARLEGVKARVAPILYMEGA-CGVRLKaDDDVSEIFKNGraSISLGYIGIHETINALAGDTHmYDSE 511
Cdd:TIGR02487 318 EYLEIAKEALEIRREYLKKMLAKDLPPMYSQGGwDGGNLL-DESVEEILKSG--TNSIGFIGLNEALVALTGKHL-HEEE 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 512 ALREKGIAIVQRLRDAVDQWKEETGYGFSLYSTPSENLCDRFCRLDTAEFGIVEGVTDKGYYTNSFHLDVEKKVNPYDKI 591
Cdd:TIGR02487 394 EARELAIRILEFIRDKADEFKKETGLNYSVYATPAESLCGRFAKKDREEFGEIPGVTDKPYYTNSFHVPVYEDVNLGEKI 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 592 DFEAAYPPIASGGFICYGEYPNIQHNLKALEDVWDYSYQH-VPYYGTNTPIDECYECGFTGEFECtskgFTCPKCGNHDa 670
Cdd:TIGR02487 474 DIEAPFHPLTNGGHITYIELDEAIPDPEALKDITKKAMKNgIGYFGINPPVDVCEDCGYTGEGLN----DKCPKCGSHD- 548
|
570 580 590
....*....|....*....|....*....|....*
gi 695736012 671 arVSVTRRVCGYLGspDARPFNAGKQEEVKRRVKH 705
Cdd:TIGR02487 549 --IEVISRITGYLG--PVENWNDGKQAEFKDRKKH 579
|
|
| NRDD |
pfam13597 |
Anaerobic ribonucleoside-triphosphate reductase; |
117-705 |
0e+00 |
|
Anaerobic ribonucleoside-triphosphate reductase;
Pssm-ID: 463930 [Multi-domain] Cd Length: 554 Bit Score: 732.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 117 NANKDSKVIPTQRDLLAGIVAKHYARQHLLPRDVVSAHERGEIHYHDLDYSPFFpMFNCMLIDLKGMLTHGFKMGNAEIE 196
Cdd:pfam13597 1 NANKDSYSPSGQRLYIAGEVSKDYALRKLLPPEIADAHEEGDIHIHDLDYYALR-TPYCCGIDLRDLLENGFVTGNGVSR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 197 PPKSISTATAVTAQIIAQVASHIYGGTTINRIDEVLAPFVTASFNKHRKTaeewqipdadgyahsRTEKECYDAFQSLEY 276
Cdd:pfam13597 80 PPKHIETACAQAVNILATVQNEQAGGQAFSSFDTYLAPFVRKDYEKHLKG---------------LTYKEVKQAMQAFVY 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 277 EVNTLHTANG-QTPFVTFGFGLGTSWESR----LIQQSILRNRISGLGKNRKTAVFPKLVFAIRDGLNHKFGDPNYDIKQ 351
Cdd:pfam13597 145 NLNTMPSRRGgQTPFTNINLGLDTPKEGRdemdMIIKALLEVMLEGDGNGGTPFTFPIPIYKLKEGFNWDEGDPNYDLFE 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 352 LALECASKRMYPDILNYDQVVKVTGSFKTPMGCRSFLGVYEDENgeqIHDG-RNNLGVISLNLPRIALEAKGNEAEFWTL 430
Cdd:pfam13597 225 LAFECTAKRGYPYFSNFDSDLLPGDGYVASMGCRLRLDLRPNRK---RFGGlRGNIGVVTINLPRIAYEAAGDEDKFFEL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 431 LDERLQLARKALMTRIARLEGVKARV-APILYMEGAcgvrlkadddvseiFKNGRASISLGYIGIHETINALAGDTHMYD 509
Cdd:pfam13597 302 LDERLELAKEALLIRREVLKKLLAKGlLPFLMGEGY--------------LRGGNHTLTIGFIGLNEALKALTGKHHGES 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 510 SEAlREKGIAIVQRLRDAVDQWKEETGYGFSLYSTPSENLCDRFCRLDTAEFGIVEGVTDKGYYTNSFHLDVEKKVNPYD 589
Cdd:pfam13597 368 EEA-KEFALKILKHMREKADEWKEETGLNFSLEATPAESLSYRFAKLDKKRFGEIKGVTDKPYYTNSFHVPVDYTIDAFE 446
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 590 KIDFEAAYPPIASGGFICYGEYPNIQHNLKALEDVWDYSYQ-HVPYYGTNTPIDECYECGFTGEFEctskgfTCPKCGNH 668
Cdd:pfam13597 447 KLKLEAPFQPLTTGGHISHVELGEAQPNPEALEKLVRIAYDtGIGYFSINPPIDVCPDCGYTGEIE------ECPNCGNH 520
|
570 580 590
....*....|....*....|....*....|....*..
gi 695736012 669 DaARVSVTRRVCGYLGSPDArpFNAGKQEEVKRRVKH 705
Cdd:pfam13597 521 D-EKVEVIRRITGYLRPVSD--WNKGKQAELKDRVKH 554
|
|
| RNR_III |
cd01675 |
Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
116-685 |
0e+00 |
|
Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in strict or facultative anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). The class III enzyme from phage T4 consists of two subunits, this model covers the larger subunit which contains the active and allosteric sites.
Pssm-ID: 153084 [Multi-domain] Cd Length: 555 Bit Score: 682.87 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 116 ENANKDSKVIPTQRDLLAGIVAKHYARqHLLPRDVVSAHERGEIHYHDLDYSPffPMFNCMLIDLKGMLTHGFKMGNAEI 195
Cdd:cd01675 1 ENANVDSSPGSTMKDLAAGIVKKYYLL-KILPKEIARAHLNGDIHIHDLDYLP--LTPYCCGWDLRPLLEKGFTTGNGII 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 196 EPPKSISTATAVTAQIIAQVASHIYGGTTINRIDEVLAPFVTASFNKHRKTAeewqipdadgyahsrTEKECYDAFQSLE 275
Cdd:cd01675 78 EPPKHLSSALGHIVNFLGTVQNEQAGGQAFPEFDTYLAPFVRKDYLKYRLTA---------------TRKEIKQAMQGFI 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 276 YEVNTLHTANGQTPFVTFGFGL-------------------GTSWESRLIQQSILRNRISGLGKnRKTAVFPKLVFAIRD 336
Cdd:cd01675 143 YNLNTLSRRGGQTPFTNITLGLvcpkdlefegggepvftygDTDKEARMIQKAFLEVRLEGDAK-GRPFTFPIPTFNVTE 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 337 GLNHkfgDPNYDIKQLALECASKRMYPDILNYDQVVKVTGSfKTPMGCRSFLGVYE---DENGEQIHDGRNNLGVISLNL 413
Cdd:cd01675 222 GFNL---DPNYDLKELAFECAAKRGYPYFLNFDNSDNVPGD-VRAMGCRLFLDKNElkrGGGLEGSGDGTGNIGVVTINL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 414 PRIALEAKGNEAEFWTLLDERLQLARKALMTRIARLEGVKARVAPILYMEGACGVRLKadddvseiFKNGRASISLGYIG 493
Cdd:cd01675 298 PRIAYEARGDEEKFFELLDEYLELAKDALEIRRKRLKEALARGLPPLYQEGLGGGKLL--------FILKRHTLTIGFIG 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 494 IHETINALAGDTHmYDSEALREKGIAIVQRLRDAVDQWKEETGYGFSLYSTPSENLCDRFCRLDTAEFG-IVEGVTDKGY 572
Cdd:cd01675 370 LNEAAEALTGKGI-GESEEAREFGIRILEHIRERADEFKEETGLLYSVEATPAESLAYRFAKKDRKKYGdIIPGVTDKPY 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 573 YTNSFHLDVEKKVNPYDKIDFEAAYPPIASGGFICYGEYPNIQHNLKALEDVWDYSYQH-VPYYGTNTPIDECYECGFTG 651
Cdd:cd01675 449 YTNSFHVPVYEDIDPFEKIDIEAKLHPLTTGGHILHIELGEAKPNPEALEALVKKAAKRgVIYFGINTPIDICNDCGYIG 528
|
570 580 590
....*....|....*....|....*....|....
gi 695736012 652 EFEctskGFTCPKCGNHDaarVSVTRRVCGYLGS 685
Cdd:cd01675 529 EGE----GFKCPKCGSED---VEVISRITGYLGP 555
|
|
| PRK07111 |
PRK07111 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
1-706 |
8.26e-176 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 235937 [Multi-domain] Cd Length: 735 Bit Score: 520.28 E-value: 8.26e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 1 MTPHVMKRDGCKVPFKSERIQEAILRAAKAAGVD-----DADYCATVAEVVSSQMNErsQVDISEIQTAVENQLMAGPYK 75
Cdd:PRK07111 1 MMLYIVKRDGREVPFDEEKITNAIFKAAEAVGGEldeseAIELTQKVIKYLEEKYKE--EVTVEDIQDLVEKVLIENGHA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 76 QLARAYIEYRHDRDVQREKRGRLNQEIRGLVEQTNsallNENANKDSKVIPTQRDLLAGIVAKHYARQHLLPRDVVSAHE 155
Cdd:PRK07111 79 ETAKAYILYRAERTRIREIKSDLMKAIEEIGNDTD----RENANVSGNTPSGKMLRIASESNKDYYNLYLLPKELAKAHE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 156 RGEIHYHDLDYSPFfpMFNCMLIDLKGMLTHGFKMGNAEIEPPKSISTATAVtAQIIAQVASH-IYGGTTINRIDEVLAP 234
Cdd:PRK07111 155 NGDIHIHDLDFYNL--TTTCLQIDLKKLLERGFNTGHGYIREPKRIESAAAL-ACIILQSNQNdMHGGQSIPNFDNDMAP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 235 FVTASFNKHRKT----------------------AEEWQIPD--------------ADGYAHSRTEKECYDAFQSLEYEV 278
Cdd:PRK07111 232 FVEKTFRRHRKEilekllelgvgeevdekeslneEEELLLLLlaldfniakkaqekADELAEKETRKRTYQAMEGFIHNL 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 279 NTLHT-ANGQTPFVTFGFGLGTSWESRLIQQSILRNRISGLGKNrKTAVFPKLVFAIRDGLNHKFGDPNYDIKQLALECA 357
Cdd:PRK07111 312 NTMHSrAGAQVPFSSINYGTDTSPEGRMVCENLLLATEKGLGKG-ETPIFPIQIFRVKEGVNYNEEDPNYDLFKLACRVA 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 358 SKRMYPDILNYD----QVVKVTGSFKTP---MGCRSFlgVYEDENGEQIHDGRNNLGVISLNLPRIALEAKGNEAEFWTL 430
Cdd:PRK07111 391 AKRLFPNFSFLDapfnKEYYDKGRPPTEvatMGCRTR--VMSNVNGEEGTKGRGNLSFTTINLPRLAIEAKKDIDKFFEL 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 431 LDERLQLARKALMTRIARLEGVKARVAPILYMEG--ACGVRLKADDDVSEIFKNGraSISLGYIGIHETINALAGDTHMY 508
Cdd:PRK07111 469 LDERLELAIEQLLHRYEVQKTLKVKDFPFLMGQGlwKGSENLGPDDSIEPVLKQG--TLGIGFIGLAETLVALTGKHHGE 546
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 509 DSEAlREKGIAIVQRLRDAVDQWKEETGYGFSLYSTPSENLCDRFCRLDTAEFGIVEGVTDKGYYTNSFHLDVEKKVNPY 588
Cdd:PRK07111 547 SEEA-QELGLKIVSHMRDFCDEYKEEYKLNYSLLATPAEGLSGRFIKMDRKKFGEIKGVTDKEYYTNSFHVPVYYPISIF 625
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 589 DKIDFEAAYPPIASGGFICYGE---YPniQHNLKALEDVWDYSYQ-HVPYYGTNTPIDECYECGFTGEFECtskgfTCPK 664
Cdd:PRK07111 626 EKIEIEAPYHKLTNGGHISYVEldgDP--SKNVEAFEIIVKAMKNtNIGYGSINHPVDRCPVCGYLGVIED-----KCPK 698
|
730 740 750 760
....*....|....*....|....*....|....*....|..
gi 695736012 665 CGNHDAARVsvtRRVCGYLGSPDArpFNAGKQEEVKRRVKHL 706
Cdd:PRK07111 699 CGSTNIQRI---RRITGYLGTLDR--FNSAKKAERRDRVKHG 735
|
|
| PRK14704 |
PRK14704 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
90-706 |
1.07e-119 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 184798 [Multi-domain] Cd Length: 618 Bit Score: 371.44 E-value: 1.07e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 90 VQREKRG-RLNQEIRGLVEQTNSALLNENANKDSKVIPTQRDLLAGIVAKHYARQHLLPRDVVSAHERGEIHYHDLDYSP 168
Cdd:PRK14704 2 LQKNTRGeELMRVFETIVHGNEQDLMQENANVDGRSPMGVMGTFASESAKYYAVENLLSDQVKKAINENILYPHDLDFYA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 169 FFPMfNCMLIDLKGMLTHGFKMGNAEIEPPKSISTATAVtAQIIAQVASHI-YGGTTINRIDEVLAPFVTASFNKHRKTA 247
Cdd:PRK14704 82 TGTT-TCSQIPLAQMLANGFHTGHGHMRQPQDIKSALAL-SSIIFQANQNMqHGGQSFALFDVDLAPYVRKTVERHKKRL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 248 EE--WQIPDADGYAHSRTEKECYDAFQSLEYEVNTLHT-ANGQTPFVTFGFGLGTSWESRLIQQSILRNRISGLGKNrKT 324
Cdd:PRK14704 160 QSypLTKEQIEEFAWKETENDTYQACEAFIHNSNSMHSrGGGQVPFISINYGTDTSKEGRLLIKQLLKATQAGLGKG-ET 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 325 AVFPKLVFAIRDGLNHKFGDPNYDIKQLALECASKRMYPDILNYDQVVKVTGSFKTP------MGCRSflGVYEDENGEQ 398
Cdd:PRK14704 239 PIFPIQIFKMKKGVNFEESDPNYDLFELALETTAERLFPNFSFLDAPFNAVHYDGRPesevcyMGCRT--RVMSNIHGEE 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 399 IHDGRNNLGVISLNLPRIALEAKGNEAeFWTLLDERLQLARKALMTRIARLEGVKARVAPILYMEGA--CGVRLKADDDV 476
Cdd:PRK14704 317 TAIGRGNLSFTSINLVKLALISGSKEA-FFEALNYYLDLGIKQLLERFEYQCTKRARDFRFLYSQGVwrGGEKLQPEDSV 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 477 SEIFKNGraSISLGYIGIHETINALAGDTHMYDSEAlREKGIAIVQRLRDAVDQWKEETGYGFSLYSTPSENLCDRFCRL 556
Cdd:PRK14704 396 ASILKQG--TLSLGFIGLAECLVALTGKHHGEDEES-WKLGYEIISFMRDRMDKATEEHELNFSVIATPAEGLSGKFVKK 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 557 DTAEFGIVEGVTDKGYYTNSFHLDVEKKVNPYDKIDFEAAYPPIASGGFICYGEYP-NIQHNLKALEDVWDYSYQHVPYY 635
Cdd:PRK14704 473 DREEFGVISGITNHNYYTNSFHIPVYYNIQAINKIRLEGPFHALCNGGHITYIELDgAAMHNKKALKQIVQAMAEHGVGY 552
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 695736012 636 GT-NTPIDECYECGFTGEFECtskgfTCPKCGNHDAARVSVTRRVCGYL-GSPDArpFNAGKQEEVKRRVKHL 706
Cdd:PRK14704 553 GSiNHPVDRCKCCSYHGVIGN-----ECPSCGNEDEANIERIRRITGYLvGDMSK--WNSAKRSEEMDRVKHK 618
|
|
| PRK08270 |
PRK08270 |
ribonucleoside triphosphate reductase; |
1-666 |
5.20e-48 |
|
ribonucleoside triphosphate reductase;
Pssm-ID: 236212 [Multi-domain] Cd Length: 656 Bit Score: 180.04 E-value: 5.20e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 1 MTPHVMKRDGCKVPFKSERIQEAILRAAKAAGVDDADYCATVAEVVSSQMNERSQVDISEIQTAVENQLMAGPYKQLARA 80
Cdd:PRK08270 1 MPTKIIKRDGRIVPFDAEKITEAIAKAFKATGEFDPSEAERLALRVIEKLEDEDIPSVEEIQDIVEKVLIEAGYFKTAKA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 81 YIEYRHDRDVQREKRGRLnQEIRGLVEQTNSAL---LNENANkdskvipTQRDL------LAGIVAKHYARQHLLPRDVV 151
Cdd:PRK08270 81 YILYREQHARLRNDKKTL-LDVEDTVDEYLDREdwrVNENSN-------MGYSLqglilnISGKVTANYWLNKVYPPEIG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 152 SAHERGEIHYHDLDY-SPFfpmfnCMLIDLKGMLTHGFK--MGNAEIEPPKSISTAtavtaqiIAQVASHIY-------G 221
Cdd:PRK08270 153 EAHRNGDLHIHDLDMlSGY-----CAGWSLRDLLLEGFNgvPGKVESKPPKHFRSA-------LGQIVNFLGtlqnewaG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 222 GTTINRIDEVLAPFVtasfnkhRKtaeewqipdaDGYahsrTEKECYDAFQSLEYEVNTLHTANGQTPFVTFGFGlgtsw 301
Cdd:PRK08270 221 AQAFSSFDTYLAPFV-------RK----------DGL----SYKEVKQAIQEFVFNLNVPSRWGFQTPFTNLTFD----- 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 302 esrLIQQSILRNRISGLGKNRKTAVFPKLVfAIRDGLNHKF------GD----------PNYDIkqlalecaSKRMYPDI 365
Cdd:PRK08270 275 ---LTVPEDLKDQPVIIGGEEMDFTYGDFQ-KEMDMINRAFievmleGDangrvftfpiPTYNI--------TKDFDWDS 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 366 LNYDQVVKVTGSFKTP-----------------MGCRSFLGVYEDENgeqihdgRNN-----------LGVISLNLPRIA 417
Cdd:PRK08270 343 ENADLLFEMTAKYGLPyfqnfinsdlkpedvrsMCCRLQLDLRELRK-------RGGglfgsaeltgsIGVVTINLPRLG 415
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 418 LEAKgNEAEFWTLLDERLQLARKALMTR---IARL--EGV---KARvapilYMEGacgvrlkadddvseiFKNGRASIsl 489
Cdd:PRK08270 416 YLSK-DEEEFFARLDELMDLAKDSLEIKrkvIERLtdKGLypyTKR-----YLGT---------------LRNHFSTI-- 472
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 490 GYIGIHETI-NALAGDThmyDSEALREKGIAIVQRLRDAVDQWKEETGYGFSLYSTPSENLCDRFCRLDTAEFG--IVEG 566
Cdd:PRK08270 473 GLNGMNEAClNFLGKDI---TTEEGRAFALRVLDHMRERLVEFQEETGNLYNLEATPAEGTTYRLAKEDKKRYPdiITAG 549
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 567 VTDKGYYTNSFHLDVEKKVNPYDKIDFEAAYPPIASGG--FICY-GEY---PNIQHNL--KALEdvwdySYqHVPYYgTN 638
Cdd:PRK08270 550 TDEEPYYTNSTQLPVGYTDDPFEALELQDELQTKYTGGtvFHLYlGEAisdAEACKKLvkKALE-----NY-RLPYI-TI 622
|
730 740 750
....*....|....*....|....*....|..
gi 695736012 639 TP---IdeCYECGF-TGEFEctskgfTCPKCG 666
Cdd:PRK08270 623 TPtfsI--CPKHGYlSGEHE------FCPKCG 646
|
|
| RNR_PFL |
cd00576 |
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and ... |
153-631 |
1.11e-45 |
|
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and pyruvate formate lyase (PFL) are believed to have diverged from a common ancestor. They have a structurally similar ten-stranded alpha-beta barrel domain that hosts the active site, and are radical enzymes. RNRs are found in all organisms and provide the only mechanism by which nucleotides are converted to deoxynucleotides. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs use a diiron-tyrosyl radical while Class II RNRs use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. PFL, an essential enzyme in anaerobic bacteria, catalyzes the conversion of pyruvate and CoA to acteylCoA and formate in a mechanism that uses a glycyl radical.
Pssm-ID: 153083 [Multi-domain] Cd Length: 401 Bit Score: 168.10 E-value: 1.11e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 153 AHERGEIHYHDLDYspffPMFNCMLIDLKGMLTHGFKMGNaeiEPPKSISTATAVTAQIIAQVASH-IYGGTTINRIDEV 231
Cdd:cd00576 7 AVKSGVITVGRPDL----PFTGCVLVDYGDSLDPGIKGVN---ETAKSINEAIQKTYQIIALAASNqNGGGVSFARASSI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 232 LAPFVTASFNKHRKTaeewqipdadgyahsrtEKECYDAFQSLEYEVNTLHTANGQTPFVTFGFGLGTSWESRLIQQSIL 311
Cdd:cd00576 80 LSPYGSRDYAKGSGT-----------------ETDAVEAADAFNLALKEVGQGNGRTGAATGFIGGVHKGKGDKISQEFL 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 312 RNRISGlGKNRKTAVFPKLVFAIRDGLNhKFGDPNYDIKQLALECASKRMYPDILNydqvvkvtgsfktpmgcrsflgvy 391
Cdd:cd00576 143 NLALAN-GGEGIPLNFPNLSVRVSSDKP-GILVKAVELKQLIAEEARKTGSPGIFN------------------------ 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 392 edengeqihdGRNNLGViSLNLPRIALEA-KGNEAEFWTLLDERLQLARKALMTRIARLEGVKARVapilymegacgvrl 470
Cdd:cd00576 197 ----------DELCNLV-SLNLARIMEKAiNGSMDVVLEELEELAFLAVRALDCVIDSHDERIPTI-------------- 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 471 kadddvsEIFKNGRASISLGYIGIHETINALAGDThmYDSEALREKGIAIVQRLRDAVDQWKEETGYGFSLYSTPSENlc 550
Cdd:cd00576 252 -------ELGGDERRTVGLGIAGVADLLIKLGLEK--VGDPEADDLAAELVDQLKKHLVKATNERGFNFLLGLSPSES-- 320
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 551 drfcrldtaefgivegVTDKGYYTNSFH-------LDVEKKVNPYDKIDFEAAYPPIASGGFICYGEYPNIQHNLKALED 623
Cdd:cd00576 321 ----------------NSSGAPATNGVSpsrg*iaIVLNGDIGPEESLASVAILQFYADNGISDTITIPDSATNLDQLLA 384
|
....*...
gi 695736012 624 VWDYSYQH 631
Cdd:cd00576 385 VIDGAAAI 392
|
|
| Gly_radical |
pfam01228 |
Glycine radical; |
581-686 |
6.87e-40 |
|
Glycine radical;
Pssm-ID: 426140 [Multi-domain] Cd Length: 106 Bit Score: 141.92 E-value: 6.87e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 581 VEKKVNPYDKIDFEAAYPPIASGGFICYG-EYPNIQHNLKALEDVWDYsYQHVPYYGTNTPIDECYECGFTGEFECTSKg 659
Cdd:pfam01228 1 VAPGISPSHGADFEGPTAVLNSVGKIDYEvELDGISLNQKFLPAVLGY-YDEEGYANLNTLIDTYFEGGHHLQFNVVDR- 78
|
90 100
....*....|....*....|....*..
gi 695736012 660 FTCPKCGNHDAARVSVTRRVCGYLGSP 686
Cdd:pfam01228 79 ETLPDAQKHPEKYPDLTVRVSGYSANF 105
|
|
| ATP-cone |
pfam03477 |
ATP cone domain; |
3-90 |
8.13e-22 |
|
ATP cone domain;
Pssm-ID: 397513 [Multi-domain] Cd Length: 86 Bit Score: 90.02 E-value: 8.13e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 3 PHVMKRDGCKVPFKSERIQEAILRAAKAAGVDDADYCATVAEVVssQMNERSQVDISEIQTAVENQLMAGPYKQLARAYI 82
Cdd:pfam03477 1 MKVIKRDGRREPFDKEKIRRAIEKACEKSPDQADELASEVEEEL--EKSLEDGISTEEIQDLVEKTLAEHPDYAVARAYI 78
|
....*...
gi 695736012 83 EYRHDRDV 90
Cdd:pfam03477 79 LYRNLRKE 86
|
|
| PRK08579 |
PRK08579 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
110-708 |
2.61e-21 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 236303 [Multi-domain] Cd Length: 625 Bit Score: 98.67 E-value: 2.61e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 110 NSALLNENANKdskvIPTQRDLLAgIVAKHYARQH---LLPRDVVSAHERGEIHYHDLDYSPFFPMfnCMLIDLKGMLTH 186
Cdd:PRK08579 20 NSLDVNENANR----YPGPTGFFA-YVLEEALKESlvsLLPEPGLEAHFSGDIYIHKLPYSLYIPY--CTGHSISRLLEK 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 187 GFKMGNAEIEPPKSISTATAVTAQIIAQVASHIYGGTTINRIDEVLAPFVtasfnkhRKtaeewqipdaDGYahsrTEKE 266
Cdd:PRK08579 93 GLKTPTIISRPARHFDTFVDHVANYLITMQHYFTGAQAFSSVEWYAGPFI-------RK----------DGL----DYRK 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 267 CYDAFQSLEYEVNTLHTANGQTPFVTFGFGLGTSwESRLIQQSILRN--RISGLGKNRKTA--VFPKLVFAIRDG--LNH 340
Cdd:PRK08579 152 IKQNIQRLVYNLNYPSRVGMQTPFTNFTVTLDAP-KKMLEGDYAVYDgkKVGPLGEYEEEAklFLLALTEVLREGdaLGQ 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 341 KF---------------GDPnyDIKQLALECASKRMYPDILNyDQVVKVTGSFKtpMGCR------SFLGVY-------- 391
Cdd:PRK08579 231 PFtfpiptlmttakmlwDDP--EVFEAVFTTAAKRGSFYWLN-TRVVDPDASYA--MCCRinidknELMYAFgvggksrr 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 392 -----EDENGEQIHDGR-----------NNLGVISLNLPRIALEAKGNEAEFWTLLDERLQLARKALMTRIARLEGVkAR 455
Cdd:PRK08579 306 dledaEEEYLEKLEKQRfgglwampditGSVNVTTVNLPRIALEARGDDDKFWELYEERLELVRITLDWFRERYVKL-LK 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 456 VAPILY-MegacgVRLKADDDVSEIFKngrasiSLGYIGIHETINALAGDTHMYDSEALREKGIAI------VQRLRDAV 528
Cdd:PRK08579 385 TYPEMYsM-----IKEYLEEFPSSHFN------TIGIIGLPEAAAIYLGEPKLWTEGSRRDWLEAAelmkkmVEFAVEKA 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 529 DQWKEETGYGFSLYSTPSENLCDRFCRLDTAEFGIVEGVTDKG---YYTNSfhldvekkVNPY-------DKIDFEAAYP 598
Cdd:PRK08579 454 REWMKETGTPWNVEEVPGESAAAKLAIKDLKLFPELREYLSDPenpIYSTS--------IAPYygplelwDRIEIEEKVQ 525
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 599 PIASGGF---ICYGEYP------NIQHNLKALEDVWdYSYqhvpyygtnTP-IDECYECG--FTGEFEctskgfTCPKCG 666
Cdd:PRK08579 526 QEFTGGVmmhIFLGEEPdpealaKLTKRIMNTKLVY-WSY---------TPaITVCNKCGrsTTGLYT------RCPRCG 589
|
650 660 670 680
....*....|....*....|....*....|....*....|....*
gi 695736012 667 NHDaarVSVTRRVCGYLgspdaRP---FNAGKQEEVKRRvKHLGN 708
Cdd:PRK08579 590 SED---VEVWSRIIGYY-----RPlknWNPYRKKEFWLR-KHYSR 625
|
|
| PRK08271 |
PRK08271 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
408-705 |
3.25e-11 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 181342 [Multi-domain] Cd Length: 623 Bit Score: 66.57 E-value: 3.25e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 408 VISLNLPRIALEAKGNEaEFWTLLDERLQLARKALmtrIARLEGVKARVapilymegACGVrLKadddvseIFKNGRASI 487
Cdd:PRK08271 353 VITINLPRIAQEARDRD-DFLEILRERVDKIHKYQ---LAYREIMEERI--------AAGM-LP-------LYDAGFISL 412
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 488 SLGY--IGIHETINA--LAGDTHMYDSEalrekGIAIVQ----RLRDAVDQWKEETGYGFSLYSTPSENLC------DRF 553
Cdd:PRK08271 413 DKQFltIGINGMVEAaeFMGLTVGYNEE-----YKDFVQevlkVIYEANEKASKEYGFTFNTEFVPAENLGvklakwDRE 487
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 554 crldtAEFGIvegvtDKGYYTNSFHLDVEKKVNPYDKIDFE-AAYPPIASGGFICY---GEYPNIQHNLKALEDVWDysy 629
Cdd:PRK08271 488 -----DGYGV-----PRQCYNSYSYVVEDANTDALDKFKLHgKELDKYLSGGSALHlnlDERLSEEGYRKLLNIAAK--- 554
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 695736012 630 QHVPYYGTNTPIDECYECGFTGEfectSKGFTCPKCGNHDaarVSVTRRVCGYLGSPDArpFNAGKQEEVKRRVKH 705
Cdd:PRK08271 555 TGCNYFAFNVKITICNDCHHIDK----RTGKRCPICGSEN---IDYYTRVIGYLKRVSA--FSKVRQKEYPRRHYH 621
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
5-101 |
9.68e-10 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 62.48 E-value: 9.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 5 VMKRDGCKVPFKSERIQEAILRAAKAAGVDDADYCATVAEVVSSQMNE--RSQV-DISEIQTAVENQLMAGPYKQLARAY 81
Cdd:PRK08332 6 VMKRDGRIVPFDESRIRWAVQRAMWEVGVRDEKKLDEVVKRIVQRINElyDGKIpHIENIQDIVELELMRAGLFEVAKAY 85
|
90 100
....*....|....*....|.
gi 695736012 82 IEYRHDR-DVQREKRGRLNQE 101
Cdd:PRK08332 86 ILYRKKKaEIREEKKRILNKK 106
|
|
| PRK06406 |
PRK06406 |
vitamin B12-dependent ribonucleotide reductase; |
1-141 |
1.07e-08 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 235796 [Multi-domain] Cd Length: 771 Bit Score: 58.71 E-value: 1.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 1 MTPHVMKRDGCKVPFKSERIQEAILRA---AKAAGVDDADycaTVAEVVSSQMNERSQVDISEIQTAVENQLM-----AG 72
Cdd:PRK06406 3 MVKEVIKRDGTVVPFDKKKIAMAIYKAmlsVKNGSMEDAE---ELTDKVVERLKKYERPTVEQIQDIVEKVLMtkkinGK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 73 PYKQLARAYIEYRHDRDVQREKRgrlnqEIRGLVEQTNsalLNENANK-----------DSKVIPTQRDLLAGiVAKHYA 141
Cdd:PRK06406 80 DFTDVAKSYILYREKRRKIREEK-----ELIGVKDDLK---LTLNAIKvlearyllkdeDGKIIETPRQMFRR-VARHIA 150
|
|
| PRK12364 |
PRK12364 |
ribonucleoside-diphosphate reductase subunit alpha; |
4-102 |
7.54e-08 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 237077 [Multi-domain] Cd Length: 842 Bit Score: 55.91 E-value: 7.54e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 4 HVMKRDGCKVPFKSERIQEAILRAAKAAGVD-DADYCATVAEVVSSQMNER----SQVDISEIQTAVENQLMAGPYKQLA 78
Cdd:PRK12364 2 EIIKRNGTTEPYDREKIEVAIRKAFASVGKPiSDEIIYSLVAEVERFIKEKypngHNVSVEEIQDLVEKTLMEHGHYAEV 81
|
90 100
....*....|....*....|....
gi 695736012 79 RAYIEYRHDRDVQREKRGRLNQEI 102
Cdd:PRK12364 82 KSYILYRAQRTEKRKAREQIIKFF 105
|
|
| PRK12365 |
PRK12365 |
ribonucleoside-diphosphate reductase subunit alpha; |
5-109 |
3.24e-07 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 53.80 E-value: 3.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 5 VMKRDGCKVPFKSERIQEAILRAAKAA-GVDDADYCATVAEV----------VSSQMNERSQVDISEIQTAVENQLMAGP 73
Cdd:PRK12365 120 VIRRDGTVVHFNPMKISAALEKAFRATdKIEGMTPSSVLEEInaltqniveeILECCSQEDRIDIEKIQDIVEQQLMVVG 199
|
90 100 110
....*....|....*....|....*....|....*.
gi 695736012 74 YKQLARAYIEYRHDRDVQREKRGRLNQEIRGLVEQT 109
Cdd:PRK12365 200 HYDVAKNYILYREARARVRDNKEEDGSTEKTIAEEA 235
|
|
| PRK12365 |
PRK12365 |
ribonucleoside-diphosphate reductase subunit alpha; |
5-94 |
1.60e-06 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 51.87 E-value: 1.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 5 VMKRDGCKVPFKSERIQEAiLRAA--KAAGVDD------------ADYCATVAEVVSSQMNERSQVDISEIQTAVENQLM 70
Cdd:PRK12365 11 IVKRNGMFVPFNQNRIFQA-LEAAfrDTRSLEDhsplpedlessiRSITHQVVKEVVQKITEGQVVTVERIQDMVESQLY 89
|
90 100
....*....|....*....|....
gi 695736012 71 AGPYKQLARAYIEYRHDRDVQREK 94
Cdd:PRK12365 90 VNGLQDVARDYIVYRDDRKAHRKK 113
|
|
| PRK07207 |
PRK07207 |
ribonucleoside-diphosphate reductase subunit alpha; |
5-94 |
1.43e-05 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 235966 [Multi-domain] Cd Length: 965 Bit Score: 48.42 E-value: 1.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736012 5 VMKRDGCKVPFKSERIQEAILRA---------AKAAGVDDadycaTVAE----VVSSQMNERSQ---VDISEIQTAVENQ 68
Cdd:PRK07207 36 VIRRNGSVVPFEPSKIAVAMTKAflaveggqaAASARVRE-----TVEQlteqVVRALVRRRPSggtFHIEDIQDQVELA 110
|
90 100
....*....|....*....|....*.
gi 695736012 69 LMAGPYKQLARAYIEYRHDRDVQREK 94
Cdd:PRK07207 111 LMRSGEHKVARAYVLYREKRAQERAA 136
|
|
| |
