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Conserved domains on  [gi|695764630|ref|WP_032687668|]
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MULTISPECIES: two-component system response regulator PgtA [Raoultella]

Protein Classification

sigma-54-dependent transcriptional regulator( domain architecture ID 11454220)

sigma-54 factor interaction domain-containing protein with a domain similar to that found in the response regulator FleR from Pseudomonas aeruginosa

CATH:  3.40.50.2300
Gene Ontology:  GO:0006355|GO:0005524|GO:0000160|GO:0000156|GO:0003677
PubMed:  8830233|20226724|12618438|10966457
SCOP:  4003632

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 6-407 2.81e-107

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


:

Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 322.68  E-value: 2.81e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   6 HNILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITG 85
Cdd:COG2204    3 ARILVVDDDPDIRRLLKELLERAGYEVETAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVILLTG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630  86 HGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALAQRQSQvvrrqwQKEQLEDNLIGRSEWVTQMRQTLQQLAETDVA 165
Cdd:COG2204   83 YGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERALERRRLR------RENAEDSGLIGRSPAMQEVRRLIEKVAPSDAT 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 166 VYFHGERGTGRTLAACYLHRLSTRGDRPII-----------FGDILQGQE--------APLQAWCEQAQGGTLVLRNIEF 226
Cdd:COG2204  157 VLITGESGTGKELVARAIHRLSPRADGPFVavncaaipeelLESELFGHEkgaftgavARRIGKFELADGGTLFLDEIGE 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 227 LSQAQQLVL--AHQQAQDEP---------PCRLVATGLQPLIALVGNNLILPDLYYCFAMTQQFCPPLAQRLDDIEPLFL 295
Cdd:COG2204  237 MPLALQAKLlrVLQEREFERvggnkpipvDVRVIAATNRDLEELVEEGRFREDLYYRLNVFPIELPPLRERREDIPLLAR 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 296 HYLQQACLRLNHPVPELPAALAkKLVNRHWPNNVRELANAAKLFAVgvmpLAEIPnpllhQVEPMQLDQRVEDYERQIII 375
Cdd:COG2204  317 HFLARFAAELGKPVKLSPEALE-ALLAYDWPGNVRELENVIERAVI----LADGE-----VITAEDLPEALEEVERELIE 386

                        410       420       430
                 ....*....|....*....|....*....|..
gi 695764630 376 EALNIHQGRINDVSEYLQIPRKKLYLRMKKFG 407
Cdd:COG2204  387 RALEETGGNVSRAAELLGISRRTLYRKLKKYG 418
 
Name Accession Description Interval E-value
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 6-407 2.81e-107

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 322.68  E-value: 2.81e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   6 HNILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITG 85
Cdd:COG2204    3 ARILVVDDDPDIRRLLKELLERAGYEVETAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVILLTG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630  86 HGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALAQRQSQvvrrqwQKEQLEDNLIGRSEWVTQMRQTLQQLAETDVA 165
Cdd:COG2204   83 YGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERALERRRLR------RENAEDSGLIGRSPAMQEVRRLIEKVAPSDAT 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 166 VYFHGERGTGRTLAACYLHRLSTRGDRPII-----------FGDILQGQE--------APLQAWCEQAQGGTLVLRNIEF 226
Cdd:COG2204  157 VLITGESGTGKELVARAIHRLSPRADGPFVavncaaipeelLESELFGHEkgaftgavARRIGKFELADGGTLFLDEIGE 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 227 LSQAQQLVL--AHQQAQDEP---------PCRLVATGLQPLIALVGNNLILPDLYYCFAMTQQFCPPLAQRLDDIEPLFL 295
Cdd:COG2204  237 MPLALQAKLlrVLQEREFERvggnkpipvDVRVIAATNRDLEELVEEGRFREDLYYRLNVFPIELPPLRERREDIPLLAR 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 296 HYLQQACLRLNHPVPELPAALAkKLVNRHWPNNVRELANAAKLFAVgvmpLAEIPnpllhQVEPMQLDQRVEDYERQIII 375
Cdd:COG2204  317 HFLARFAAELGKPVKLSPEALE-ALLAYDWPGNVRELENVIERAVI----LADGE-----VITAEDLPEALEEVERELIE 386

                        410       420       430
                 ....*....|....*....|....*....|..
gi 695764630 376 EALNIHQGRINDVSEYLQIPRKKLYLRMKKFG 407
Cdd:COG2204  387 RALEETGGNVSRAAELLGISRRTLYRKLKKYG 418
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 8-136 6.84e-60

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 190.78  E-value: 6.84e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITGHG 87
Cdd:cd17549    1 VLLVDDDADVREALQQTLELAGFRVRAFADAEEALAALSPDFPGVVISDIRMPGMDGLELLAQIRELDPDLPVILITGHG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 695764630  88 DVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALAQRQSQVVRRQWQKE 136
Cdd:cd17549   81 DVPMAVEAMRAGAYDFLEKPFDPERLLDVVRRALEKRRLVLENRRLRQQ 129
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
8-409 2.03e-49

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 173.50  E-value: 2.03e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITGHG 87
Cdd:PRK11361   7 ILIVDDEDNVRRMLSTAFALQGFETHCANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRTPVILMTAYA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630  88 DVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKAL---AQRQSQVVRRQ-----WQKEQLEDNligrSEWVTQMRQTLQQL 159
Cdd:PRK11361  87 EVETAVEALRCGAFDYVIKPFDLDELNLIVQRALqlqSMKKEIRHLHQalstsWQWGHILTN----SPAMMDICKDTAKI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 160 AETDVAVYFHGERGTGRTLAACYLHRLSTRGDRPII----------------FGD---ILQGQEAPLQAWCEQAQGGTLV 220
Cdd:PRK11361 163 ALSQASVLISGESGTGKELIARAIHYNSRRAKGPFIkvncaalpeslleselFGHekgAFTGAQTLRQGLFERANEGTLL 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 221 LRNIEFLSQAQQLVL-------------AHQQAQDEppCRLVATGLQPLIALVGNNLILPDLYYCFAMTQQFCPPLAQRL 287
Cdd:PRK11361 243 LDEIGEMPLVLQAKLlrilqereferigGHQTIKVD--IRIIAATNRDLQAMVKEGTFREDLFYRLNVIHLILPPLRDRR 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 288 DDIEPLFLHYLQQACLRLNHPVPEL-PAALAkKLVNRHWPNNVRELANA---AKLFAVGVMPLAE-IPNPLLHQVEPM-- 360
Cdd:PRK11361 321 EDISLLANHFLQKFSSENQRDIIDIdPMAMS-LLTAWSWPGNIRELSNVierAVVMNSGPIIFSEdLPPQIRQPVCNAge 399

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 695764630 361 ---------QLDQRVEDYERQIIIEALNIHQGRINDVSEYLQIPRKKLYLRMKKFGLD 409
Cdd:PRK11361 400 vktapvgerNLKEEIKRVEKRIIMEVLEQQEGNRTRTALMLGISRRALMYKLQEYGID 457
PEP_resp_reg TIGR02915
PEP-CTERM-box response regulator transcription factor; Members of this protein family share ...
 8-408 1.41e-39

PEP-CTERM-box response regulator transcription factor; Members of this protein family share full-length homology with (but do not include) the acetoacetate metabolism regulatory protein AtoC (see SP|Q06065). These proteins have a Fis family DNA binding sequence (pfam02954), a response regulator receiver domain (pfam00072), and sigma-54 interaction domain (pfam00158). [Regulatory functions, DNA interactions]


Pssm-ID: 274348 [Multi-domain]  Cd Length: 445  Bit Score: 146.82  E-value: 1.41e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630    8 ILLIDDDsdvLDAYTQL-LTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMP-----HCSGIDLLKILLKHDPHLPVI 81
Cdd:TIGR02915   1 LLIVEDD---LGLQKQLkWSFADYELAVAADRESAIALVRRHEPAVVTLDLGLPpdadgASEGLAALQQILAIAPDTKVI 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   82 LITGHGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALA----QRQSQVVRRQWQKEQLEdNLIGRSEWVTQMRQTLQ 157
Cdd:TIGR02915  78 VITGNDDRENAVKAIGLGAYDFYQKPIDPDVLKLIVDRAFHlytlETENRRLQSALGGTALR-GLITSSPGMQKICRTIE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630  158 QLAETDVAVYFHGERGTGRTLAACYLHRLSTRGDRPII----------------FG---DILQGQEAPLQAWCEQAQGGT 218
Cdd:TIGR02915 157 KIAPSDITVLLLGESGTGKEVLARALHQLSDRKDKRFVaincaaipenlleselFGyekGAFTGAVKQTLGKIEYAHGGT 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630  219 LVLRNI---------EFLSQAQQLVLAHQQAQDEPP--CRLVATGLQPLIALVGNNLILPDLYYCFAMTQQFCPPLAQRL 287
Cdd:TIGR02915 237 LFLDEIgdlplnlqaKLLRFLQERVIERLGGREEIPvdVRIVCATNQDLKRMIAEGTFREDLFYRIAEISITIPPLRSRD 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630  288 DDIEPLFLHYLQQACLRLNHPVPELPAALAKKLVNRHWPNNVRELANAAK------------LFAVGVMPLAEIPNPLLh 355
Cdd:TIGR02915 317 GDAVLLANAFLERFARELKRKTKGFTDDALRALEAHAWPGNVRELENKVKravimaegnqitAEDLGLDARERAETPLE- 395

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 695764630  356 qvepMQLDQRVEDYERQIIIEALNIHQGRINDVSEYLQIPRKKLYLRMKKFGL 408
Cdd:TIGR02915 396 ----VNLREVRERAEREAVRKAIARVDGNIARAAELLGITRPTLYDLMKKHGI 444
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 8-118 6.07e-34

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 122.26  E-value: 6.07e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630    8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITGHG 87
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTAHG 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 695764630   88 DVPMAVEAVKKGAWDFLQKPVNPGQLLDLID 118
Cdd:pfam00072  81 DEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
tetrathio_RR NF040749
tetrathionate respiration response regulator TtrR;
8-132 8.38e-24

tetrathionate respiration response regulator TtrR;


Pssm-ID: 468713 [Multi-domain]  Cd Length: 191  Bit Score: 97.81  E-value: 8.38e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDplrAQDLVSEA---WPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILIT 84
Cdd:NF040749   2 IHLVDDDVAVTDACRFLLESLGYEVQCWND---SEAFLAQAdlyQEGVVLLDMRMPGLDGHQVHQALREQGSTLAVVFLT 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 695764630  85 GHGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALAQRQSQVVRRQ 132
Cdd:NF040749  79 GHGDVPMAVEQMKLGAVDFLQKPVSAAPLQAALERALAVSAAAFERHQ 126
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 8-60 2.34e-08

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 49.87  E-value: 2.34e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 695764630     8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMP 60
Cdd:smart00448   3 ILVVDDDPLLRELLKALLEKEGYEVDEATDGEEALELLKEEKPDLILLDIMMP 55
 
Name Accession Description Interval E-value
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 6-407 2.81e-107

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 322.68  E-value: 2.81e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   6 HNILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITG 85
Cdd:COG2204    3 ARILVVDDDPDIRRLLKELLERAGYEVETAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVILLTG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630  86 HGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALAQRQSQvvrrqwQKEQLEDNLIGRSEWVTQMRQTLQQLAETDVA 165
Cdd:COG2204   83 YGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERALERRRLR------RENAEDSGLIGRSPAMQEVRRLIEKVAPSDAT 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 166 VYFHGERGTGRTLAACYLHRLSTRGDRPII-----------FGDILQGQE--------APLQAWCEQAQGGTLVLRNIEF 226
Cdd:COG2204  157 VLITGESGTGKELVARAIHRLSPRADGPFVavncaaipeelLESELFGHEkgaftgavARRIGKFELADGGTLFLDEIGE 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 227 LSQAQQLVL--AHQQAQDEP---------PCRLVATGLQPLIALVGNNLILPDLYYCFAMTQQFCPPLAQRLDDIEPLFL 295
Cdd:COG2204  237 MPLALQAKLlrVLQEREFERvggnkpipvDVRVIAATNRDLEELVEEGRFREDLYYRLNVFPIELPPLRERREDIPLLAR 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 296 HYLQQACLRLNHPVPELPAALAkKLVNRHWPNNVRELANAAKLFAVgvmpLAEIPnpllhQVEPMQLDQRVEDYERQIII 375
Cdd:COG2204  317 HFLARFAAELGKPVKLSPEALE-ALLAYDWPGNVRELENVIERAVI----LADGE-----VITAEDLPEALEEVERELIE 386

                        410       420       430
                 ....*....|....*....|....*....|..
gi 695764630 376 EALNIHQGRINDVSEYLQIPRKKLYLRMKKFG 407
Cdd:COG2204  387 RALEETGGNVSRAAELLGISRRTLYRKLKKYG 418
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 8-136 6.84e-60

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 190.78  E-value: 6.84e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITGHG 87
Cdd:cd17549    1 VLLVDDDADVREALQQTLELAGFRVRAFADAEEALAALSPDFPGVVISDIRMPGMDGLELLAQIRELDPDLPVILITGHG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 695764630  88 DVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALAQRQSQVVRRQWQKE 136
Cdd:cd17549   81 DVPMAVEAMRAGAYDFLEKPFDPERLLDVVRRALEKRRLVLENRRLRQQ 129
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
8-409 2.03e-49

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 173.50  E-value: 2.03e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITGHG 87
Cdd:PRK11361   7 ILIVDDEDNVRRMLSTAFALQGFETHCANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRTPVILMTAYA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630  88 DVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKAL---AQRQSQVVRRQ-----WQKEQLEDNligrSEWVTQMRQTLQQL 159
Cdd:PRK11361  87 EVETAVEALRCGAFDYVIKPFDLDELNLIVQRALqlqSMKKEIRHLHQalstsWQWGHILTN----SPAMMDICKDTAKI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 160 AETDVAVYFHGERGTGRTLAACYLHRLSTRGDRPII----------------FGD---ILQGQEAPLQAWCEQAQGGTLV 220
Cdd:PRK11361 163 ALSQASVLISGESGTGKELIARAIHYNSRRAKGPFIkvncaalpeslleselFGHekgAFTGAQTLRQGLFERANEGTLL 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 221 LRNIEFLSQAQQLVL-------------AHQQAQDEppCRLVATGLQPLIALVGNNLILPDLYYCFAMTQQFCPPLAQRL 287
Cdd:PRK11361 243 LDEIGEMPLVLQAKLlrilqereferigGHQTIKVD--IRIIAATNRDLQAMVKEGTFREDLFYRLNVIHLILPPLRDRR 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 288 DDIEPLFLHYLQQACLRLNHPVPEL-PAALAkKLVNRHWPNNVRELANA---AKLFAVGVMPLAE-IPNPLLHQVEPM-- 360
Cdd:PRK11361 321 EDISLLANHFLQKFSSENQRDIIDIdPMAMS-LLTAWSWPGNIRELSNVierAVVMNSGPIIFSEdLPPQIRQPVCNAge 399

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 695764630 361 ---------QLDQRVEDYERQIIIEALNIHQGRINDVSEYLQIPRKKLYLRMKKFGLD 409
Cdd:PRK11361 400 vktapvgerNLKEEIKRVEKRIIMEVLEQQEGNRTRTALMLGISRRALMYKLQEYGID 457
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 8-136 1.95e-42

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 147.55  E-value: 1.95e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITGHG 87
Cdd:COG4566    2 VYIVDDDEAVRDSLAFLLESAGLRVETFASAEAFLAALDPDRPGCLLLDVRMPGMSGLELQEELAARGSPLPVIFLTGHG 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 695764630  88 DVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALAQRQSQVVRRQWQKE 136
Cdd:COG4566   82 DVPMAVRAMKAGAVDFLEKPFDDQALLDAVRRALARDRARRAERARRAE 130
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
1-405 1.08e-41

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 152.49  E-value: 1.08e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   1 MLTDHHNILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPV 80
Cdd:PRK10365   1 MTHDNIDILVVDDDISHCTILQALLRGWGYNVALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNPAIPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630  81 ILITGHGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALAQRQ------SQVVRRQWqkeqledNLIGRSEWVTQMRQ 154
Cdd:PRK10365  81 LIMTAYSSVETAVEALKTGALDYLIKPLDFDNLQATLEKALAHTHsidaetPAVTASQF-------GMVGKSPAMQHLLS 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 155 TLQQLAETDVAVYFHGERGTGRTLAACYLHRLSTRGDRPII----------------FGD---ILQGQEAPLQAWCEQAQ 215
Cdd:PRK10365 154 EIALVAPSEATVLIHGDSGTGKELVARAIHASSARSEKPLVtlncaalneslleselFGHekgAFTGADKRREGRFVEAD 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 216 GGTLVLRNIEFLSQAQQLVLAHQQAQDEPP-----------CRLVATGLQPLIALVGNNLILPDLYYCFAMTQQFCPPLA 284
Cdd:PRK10365 234 GGTLFLDEIGDISPMMQVRLLRAIQEREVQrvgsnqtisvdVRLIAATHRDLAAEVNAGRFRQDLYYRLNVVAIEVPSLR 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 285 QRLDDIEPLFLHYLQQACLRLNHPVPELPAALAKKLVNRHWPNNVRELANAAKLFAVGV---------MPLAEIPNPLlh 355
Cdd:PRK10365 314 QRREDIPLLAGHFLQRFAERNRKAVKGFTPQAMDLLIHYDWPGNIRELENAVERAVVLLtgeyisereLPLAIASTPI-- 391

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 695764630 356 QVEPMQLDQRVEDYERQIIIEALNIHQGRINDVSEYLQIPRKKLYLRMKK 405
Cdd:PRK10365 392 PLGQSQDIQPLVEVEKEVILAALEKTGGNKTEAARQLGITRKTLLAKLSR 441
PEP_resp_reg TIGR02915
PEP-CTERM-box response regulator transcription factor; Members of this protein family share ...
 8-408 1.41e-39

PEP-CTERM-box response regulator transcription factor; Members of this protein family share full-length homology with (but do not include) the acetoacetate metabolism regulatory protein AtoC (see SP|Q06065). These proteins have a Fis family DNA binding sequence (pfam02954), a response regulator receiver domain (pfam00072), and sigma-54 interaction domain (pfam00158). [Regulatory functions, DNA interactions]


Pssm-ID: 274348 [Multi-domain]  Cd Length: 445  Bit Score: 146.82  E-value: 1.41e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630    8 ILLIDDDsdvLDAYTQL-LTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMP-----HCSGIDLLKILLKHDPHLPVI 81
Cdd:TIGR02915   1 LLIVEDD---LGLQKQLkWSFADYELAVAADRESAIALVRRHEPAVVTLDLGLPpdadgASEGLAALQQILAIAPDTKVI 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   82 LITGHGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALA----QRQSQVVRRQWQKEQLEdNLIGRSEWVTQMRQTLQ 157
Cdd:TIGR02915  78 VITGNDDRENAVKAIGLGAYDFYQKPIDPDVLKLIVDRAFHlytlETENRRLQSALGGTALR-GLITSSPGMQKICRTIE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630  158 QLAETDVAVYFHGERGTGRTLAACYLHRLSTRGDRPII----------------FG---DILQGQEAPLQAWCEQAQGGT 218
Cdd:TIGR02915 157 KIAPSDITVLLLGESGTGKEVLARALHQLSDRKDKRFVaincaaipenlleselFGyekGAFTGAVKQTLGKIEYAHGGT 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630  219 LVLRNI---------EFLSQAQQLVLAHQQAQDEPP--CRLVATGLQPLIALVGNNLILPDLYYCFAMTQQFCPPLAQRL 287
Cdd:TIGR02915 237 LFLDEIgdlplnlqaKLLRFLQERVIERLGGREEIPvdVRIVCATNQDLKRMIAEGTFREDLFYRIAEISITIPPLRSRD 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630  288 DDIEPLFLHYLQQACLRLNHPVPELPAALAKKLVNRHWPNNVRELANAAK------------LFAVGVMPLAEIPNPLLh 355
Cdd:TIGR02915 317 GDAVLLANAFLERFARELKRKTKGFTDDALRALEAHAWPGNVRELENKVKravimaegnqitAEDLGLDARERAETPLE- 395

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 695764630  356 qvepMQLDQRVEDYERQIIIEALNIHQGRINDVSEYLQIPRKKLYLRMKKFGL 408
Cdd:TIGR02915 396 ----VNLREVRERAEREAVRKAIARVDGNIARAAELLGITRPTLYDLMKKHGI 444
PRK15115 PRK15115
response regulator GlrR; Provisional
 7-334 2.56e-37

response regulator GlrR; Provisional


Pssm-ID: 185070 [Multi-domain]  Cd Length: 444  Bit Score: 140.74  E-value: 2.56e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   7 NILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITGH 86
Cdd:PRK15115   7 HLLLVDDDPGLLKLLGMRLTSEGYSVVTAESGQEALRVLNREKVDLVISDLRMDEMDGMQLFAEIQKVQPGMPVIILTAH 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630  87 GDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALAQRQSqVVRRQWQKEqlednLIGRSewvTQMRQTLQQ---LAETD 163
Cdd:PRK15115  87 GSIPDAVAATQQGVFSFLTKPVDRDALYKAIDDALEQSAP-ATDERWREA-----IVTRS---PLMLRLLEQarmVAQSD 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 164 VAVYFHGERGTGRTLAACYLHRLSTRGDRPII-----------------------FGDILQGQEAPLQAwceqAQGGTLV 220
Cdd:PRK15115 158 VSVLINGQSGTGKEILAQAIHNASPRASKPFIaincgalpeqlleselfghargaFTGAVSNREGLFQA----AEGGTLF 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 221 LRNIEFLSQAQQ--LVLAHQQAQDEP---------PCRLVATGLQPLIALVGNNLILPDLYYCFAMTQQFCPPLAQRLDD 289
Cdd:PRK15115 234 LDEIGDMPAPLQvkLLRVLQERKVRPlgsnrdidiDVRIISATHRDLPKAMARGEFREDLYYRLNVVSLKIPALAERTED 313

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 695764630 290 IEPLFLHYLQQACLRLNHPVPELPAALAKKLVNRHWPNNVRELAN 334
Cdd:PRK15115 314 IPLLANHLLRQAAERHKPFVRAFSTDAMKRLMTASWPGNVRQLVN 358
RocR COG3829
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...
 140-409 6.70e-37

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];


Pssm-ID: 443041 [Multi-domain]  Cd Length: 448  Bit Score: 139.52  E-value: 6.70e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 140 DNLIGRSEWVTQMRQTLQQLAETDVAVYFHGERGTGRTLAACYLHRLSTRGDRPII----------------FG------ 197
Cdd:COG3829  138 DDIIGKSPAMKELLELAKRVAKSDSTVLILGESGTGKELFARAIHNASPRRDGPFVavncaaipenlleselFGyekgaf 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 198 --DILQGQEAPLqawcEQAQGGTLVLRNIEFLSQAQQ---L-VLahqqaQD---EP-----P----CRLVATGLQPLIAL 259
Cdd:COG3829  218 tgAKKGGKPGLF----ELADGGTLFLDEIGEMPLSLQaklLrVL-----QEkevRRvggtkPipvdVRIIAATNRDLEEM 288

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 260 VGNNLILPDLYY---CFAMTqqfCPPLAQRLDDIEPLFLHYLQQACLRLNHPVPELPAALAKKLVNRHWPNNVRELANAA 336
Cdd:COG3829  289 VEEGRFREDLYYrlnVIPIH---IPPLRERKEDIPLLAEHFLEKFNKKYGKNIKGISPEALELLLAYDWPGNVRELENVI 365

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 337 KlFAVGVMPLAEI-----PNPLL------HQVEPMQLDQRVEDYERQIIIEALNIHQGRINDVSEYLQIPRKKLYLRMKK 405
Cdd:COG3829  366 E-RAVVLSEGDVItpehlPEYLLeeaeaaSAAEEGSLKEALEEVEKELIEEALEKTGGNKSKAAKALGISRSTLYRKLKK 444


                 ....
gi 695764630 406 FGLD 409
Cdd:COG3829  445 YGIK 448
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 7-341 6.47e-36

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 137.31  E-value: 6.47e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   7 NILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITGH 86
Cdd:PRK10923   5 IVWVVDDDSSIRWVLERALAGAGLTCTTFENGNEVLEALASKTPDVLLSDIRMPGMDGLALLKQIKQRHPMLPVIIMTAH 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630  87 GDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALAQRQSQVVRRQWQKEQLEDNLIGRSEWVTQMRQTLQQLAETDVAV 166
Cdd:PRK10923  85 SDLDAAVSAYQQGAFDYLPKPFDIDEAVALVERAISHYQEQQQPRNIQVNGPTTDIIGEAPAMQDVFRIIGRLSRSSISV 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 167 YFHGERGTGRTLAACYLHRLSTRGDRPII----------------FGD---ILQGQEAPLQAWCEQAQGGTLVLRNIEFL 227
Cdd:PRK10923 165 LINGESGTGKELVAHALHRHSPRAKAPFIalnmaaipkdlieselFGHekgAFTGANTIRQGRFEQADGGTLFLDEIGDM 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 228 S---QAQQL-VLAHQQ-------AQDEPPCRLVATGLQPLIALVGNNLILPDLYYCFAMTQQFCPPLAQRLDDIEPLFLH 296
Cdd:PRK10923 245 PldvQTRLLrVLADGQfyrvggyAPVKVDVRIIAATHQNLEQRVQEGKFREDLFHRLNVIRVHLPPLRERREDIPRLARH 324

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 695764630 297 YLQQACLRLNHPVPELPAALAKKLVNRHWPNNVRELANAAKLFAV 341
Cdd:PRK10923 325 FLQVAARELGVEAKLLHPETEAALTRLAWPGNVRQLENTCRWLTV 369
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 8-118 6.07e-34

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 122.26  E-value: 6.07e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630    8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITGHG 87
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTAHG 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 695764630   88 DVPMAVEAVKKGAWDFLQKPVNPGQLLDLID 118
Cdd:pfam00072  81 DEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 8-121 2.42e-31

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 115.77  E-value: 2.42e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRV--YACGDPLRAQdlVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITG 85
Cdd:cd17537    3 VYVVDDDEAVRDSLAFLLRSVGLAVktFTSASAFLAA--APPDQPGCLVLDVRMPGMSGLELQDELLARGSNIPIIFITG 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 695764630  86 HGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKAL 121
Cdd:cd17537   81 HGDVPMAVEAMKAGAVDFLEKPFRDQVLLDAIEQAL 116
AcoR COG3284
Transcriptional regulator DhaR of acetoin/glycerol metabolism [Transcription];
140-407 3.46e-30

Transcriptional regulator DhaR of acetoin/glycerol metabolism [Transcription];


Pssm-ID: 442514 [Multi-domain]  Cd Length: 625  Bit Score: 122.70  E-value: 3.46e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 140 DNLIGRSEWVTQMRQTLQQLAETDVAVYFHGERGTGRTLAACYLHRLSTRGDRPIIF---GDI--------LQGQE---- 204
Cdd:COG3284  321 AALAGGDPAMRRALRRARRLADRDIPVLILGETGTGKELFARAIHAASPRADGPFVAvncAAIpeelieseLFGYEpgaf 400

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 205 -------APLQAwcEQAQGGTLVLRNIEFLSQAQQLVLAH--QQAQDEP---------PCRLVATGLQPLIALVGNNLIL 266
Cdd:COG3284  401 tgarrkgRPGKI--EQADGGTLFLDEIGDMPLALQARLLRvlQEREVTPlggtkpipvDVRLIAATHRDLRELVAAGRFR 478

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 267 PDLYYCFAMTQQFCPPLAQRlDDIEPLFLHYLQQACLRlnHPVPELPAALAKKLVNRHWPNNVRELAN----AAKLFAVG 342
Cdd:COG3284  479 EDLYYRLNGLTLTLPPLRER-EDLPALIEHLLRELAAG--RGPLRLSPEALALLAAYPWPGNVRELRNvlrtALALADGG 555

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 343 VMPLAEIPNPLLHQVEPMQLDQ-----RVEDYERQIIIEALNIHQGRINDVSEYLQIPRKKLYLRMKKFG 407
Cdd:COG3284  556 VITVEDLPDELRAELAAAAPAAaapltSLEEAERDAILRALRACGGNVSAAARALGISRSTLYRKLKRYG 625
fixJ PRK09390
response regulator FixJ; Provisional
 7-125 7.47e-30

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 114.33  E-value: 7.47e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   7 NILLIDDDSDVLDAYTQLLTQAGH--RVYAcgdplRAQDL---VSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVI 81
Cdd:PRK09390   5 VVHVVDDDEAMRDSLAFLLDSAGFevRLFE-----SAQAFldaLPGLRFGCVVTDVRMPGIDGIELLRRLKARGSPLPVI 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 695764630  82 LITGHGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALAQRQ 125
Cdd:PRK09390  80 VMTGHGDVPLAVEAMKLGAVDFIEKPFEDERLIGAIERALAQAP 123
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 9-107 1.00e-29

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 110.78  E-value: 1.00e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   9 LLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITGHGD 88
Cdd:cd00156    1 LIVDDDPAIRELLKSLLEREGYEVDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVLTAKAD 80

                         90
                 ....*....|....*....
gi 695764630  89 VPMAVEAVKKGAWDFLQKP 107
Cdd:cd00156   81 EEDAVRALELGADDYLVKP 99
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 7-138 1.69e-28

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 111.41  E-value: 1.69e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   7 NILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKiLLKHDP---HLPVILI 83
Cdd:COG3437    8 TVLIVDDDPENLELLRQLLRTLGYDVVTAESGEEALELLLEAPPDLILLDVRMPGMDGFELLR-LLRADPstrDIPVIFL 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 695764630  84 TGHGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALAQRQSQVVRRQWQKEQL 138
Cdd:COG3437   87 TALADPEDRERALEAGADDYLTKPFDPEELLARVRNALELRRLQRELDDLVLYLK 141
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 8-122 7.14e-28

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 106.43  E-value: 7.14e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITGHG 87
Cdd:cd17550    1 ILIVDDEEDIRESLSGILEDEGYEVDTAADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKEKYPDLPVIMISGHG 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 695764630  88 DVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALA 122
Cdd:cd17550   81 TIETAVKATKLGAYDFIEKPLSLDRLLLTIERALE 115
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 7-126 9.30e-27

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 103.78  E-value: 9.30e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   7 NILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHD--PHLPVILIT 84
Cdd:COG0784    7 RILVVDDNPDNRELLRRLLERLGYEVTTAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIRALPrlPDIPIIALT 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 695764630  85 GHGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALAQRQS 126
Cdd:COG0784   87 AYADEEDRERALEAGADDYLTKPVDPEELLEALRRLLARASA 128
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 6-130 8.55e-26

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 103.50  E-value: 8.55e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   6 HNILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITG 85
Cdd:COG0745    2 PRILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIMLTA 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 695764630  86 HGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALAQRQSQVVR 130
Cdd:COG0745   82 RDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRRAAEVLR 126
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 8-118 1.38e-25

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 102.29  E-value: 1.38e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKiLLKHDP---HLPVILIT 84
Cdd:COG3706    4 ILVVDDDPTNRKLLRRLLEAAGYEVVEAADGEEALELLQEHRPDLILLDLEMPDMDGLELCR-RLRADPrtaDIPIIFLT 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 695764630  85 GHGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLID 118
Cdd:COG3706   83 ALDDEEDRARALEAGADDYLTKPFDPEELLARVD 116
FhlA COG3604
FhlA-type transcriptional regulator, contains GAF, AAA-type ATPase, and DNA-binding Fis ...
 153-409 2.11e-25

FhlA-type transcriptional regulator, contains GAF, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];


Pssm-ID: 442823 [Multi-domain]  Cd Length: 338  Bit Score: 105.70  E-value: 2.11e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 153 RQTLQQLAETdVAVYFHGERGTGRTLAACYLHRLSTRGDRPIIFGDI----------LQGQEAplqawceQAQGGTLVLR 222
Cdd:COG3604  106 LRLLETLASL-AAVAILGETGTGKELVANAIHELSPRADKPFVKVNCaalpesllesLQEGEF-------ERVGGDETIK 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 223 -NIeflsqaqqlvlahqqaqdeppcRLVATGLQPLIALVGNNLILPDLYYCFAMTQQFCPPLAQRLDDIEPLFLHYLQQA 301
Cdd:COG3604  178 vDV----------------------RIIAATNRDLEEEVAEGRFREDLYYRLNVFPIRLPPLRERREDIPLLAEHFLEKF 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 302 CLRLNHPVPELPAALAKKLVNRHWPNNVRELAN----AAKLFAVGVMPLAEIPNpllhqvepmQLDQRVEDYERQIIIEA 377
Cdd:COG3604  236 SRRLGKPILRLSPEALEALMAYPWPGNVRELENvierAVILAEGGVLDADDLAP---------GSREALEEVEREHILEA 306

                        250       260       270
                 ....*....|....*....|....*....|..
gi 695764630 378 LNIHQGRINDVSEYLQIPRKKLYLRMKKFGLD 409
Cdd:COG3604  307 LERTGGNIAGAARLLGLTPSTLRSRMKKLGIK 338
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 3-157 7.53e-25

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 99.99  E-value: 7.53e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   3 TDHHNILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVIL 82
Cdd:COG4567    2 AEDRSLLLVDDDEAFARVLARALERRGFEVTTAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDPDARIVV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630  83 ITGHGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALAQRQSQ------VVRRQWQKEQ--LEDNLIGRSEW--VTQM 152
Cdd:COG4567   82 LTGYASIATAVEAIKLGADDYLAKPADADDLLAALERAEGDAPAPpenpmsLDRLEWEHIQrvLAECDGNISATarALGM 161


                 ....*.
gi 695764630 153 -RQTLQ 157
Cdd:COG4567  162 hRRTLQ 167
tetrathio_RR NF040749
tetrathionate respiration response regulator TtrR;
8-132 8.38e-24

tetrathionate respiration response regulator TtrR;


Pssm-ID: 468713 [Multi-domain]  Cd Length: 191  Bit Score: 97.81  E-value: 8.38e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDplrAQDLVSEA---WPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILIT 84
Cdd:NF040749   2 IHLVDDDVAVTDACRFLLESLGYEVQCWND---SEAFLAQAdlyQEGVVLLDMRMPGLDGHQVHQALREQGSTLAVVFLT 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 695764630  85 GHGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALAQRQSQVVRRQ 132
Cdd:NF040749  79 GHGDVPMAVEQMKLGAVDFLQKPVSAAPLQAALERALAVSAAAFERHQ 126
PRK11388 PRK11388
DNA-binding transcriptional regulator DhaR; Provisional
 106-411 8.72e-24

DNA-binding transcriptional regulator DhaR; Provisional


Pssm-ID: 183114 [Multi-domain]  Cd Length: 638  Bit Score: 103.60  E-value: 8.72e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 106 KPVNPGQ------LLDLIDKALAQRQSQVVRRQWQKEQLednligrSEWVTQMRQTL---QQLAETDVAVYFHGERGTGR 176
Cdd:PRK11388 289 KPIIEGQgtsfilLLHPVEQMRQLMTSQLGKVSHTFDHM-------PQDSPQMRRLIhfgRQAAKSSFPVLLCGEEGVGK 361

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 177 TLAACYLHRLSTRGDRPII----------------FGDILQGQEAPLQAWCEQAQGGTLVLRNIEFLSQAQQLVLAH--- 237
Cdd:PRK11388 362 ALLAQAIHNESERAAGPYIavncqlypdealaeefLGSDRTDSENGRLSKFELAHGGTLFLEKVEYLSPELQSALLQvlk 441

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 238 ------QQAQDEPPC--RLVATGLQPLIALVGNNLILPDLYYCFAMTQQFCPPLAQRLDDIEPLFLHYLQQACLRLNHPV 309
Cdd:PRK11388 442 tgvitrLDSRRLIPVdvRVIATTTADLAMLVEQNRFSRQLYYALHAFEITIPPLRMRREDIPALVNNKLRSLEKRFSTRL 521

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 310 PELPAALAKkLVNRHWPNNVRELANAAKLFAV----GVMPLAEIPNPLLHQ-------VEPMQLDQRVEDYERQIIIEAL 378
Cdd:PRK11388 522 KIDDDALAR-LVSYRWPGNDFELRSVIENLALssdnGRIRLSDLPEHLFTEqatddvsATRLSTSLSLAELEKEAIINAA 600

                        330       340       350
                 ....*....|....*....|....*....|...
gi 695764630 379 NIHQGRINDVSEYLQIPRKKLYLRMKKFGLDKH 411
Cdd:PRK11388 601 QVCGGRIQEMAALLGIGRTTLWRKMKQHGIDAG 633
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 7-107 1.48e-23

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 94.07  E-value: 1.48e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   7 NILLIDDDSDVLDAYTQLLTQAG--HRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILIT 84
Cdd:COG4753    1 KVLIVDDEPLIREGLKRILEWEAgfEVVGEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEAIRELDPDTKIIILS 80

                         90       100
                 ....*....|....*....|...
gi 695764630  85 GHGDVPMAVEAVKKGAWDFLQKP 107
Cdd:COG4753   81 GYSDFEYAQEAIKLGADDYLLKP 103
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 3-138 8.83e-23

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 93.11  E-value: 8.83e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   3 TDHHNILLIDDDSDVLDAYTQLLTQ-AGHR-VYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPV 80
Cdd:COG4565    1 MKMIRVLIVEDDPMVAELLRRYLERlPGFEvVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRARGPDVDV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 695764630  81 ILITGHGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALAQRQSQvvrRQWQKEQL 138
Cdd:COG4565   81 IVITAARDPETVREALRAGVVDYLIKPFTFERLREALERYLEYRRLL---REDQEEDL 135
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 8-121 4.92e-21

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 87.71  E-value: 4.92e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITGHG 87
Cdd:cd19919    3 VWIVDDDSSIRWVLERALAGAGLTVTSFENAQEALAALASSQPDVLISDIRMPGMDGLALLAQIKQRHPDLPVIIMTAHS 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 695764630  88 DVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKAL 121
Cdd:cd19919   83 DLDSAVSAYQGGAFEYLPKPFDIDEAVALVERAI 116
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 8-123 9.14e-21

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 87.01  E-value: 9.14e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGH---RVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILIT 84
Cdd:cd17536    1 VLIVDDEPLIREGLKKLIDWEELgfeVVGEAENGEEALELIEEHKPDIVITDIRMPGMDGLELIEKIRELYPDIKIIILS 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 695764630  85 GHGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALAQ 123
Cdd:cd17536   81 GYDDFEYAQKAIRLGVVDYLLKPVDEEELEEALEKAKEE 119
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 8-125 1.25e-20

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 86.87  E-value: 1.25e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITGHG 87
Cdd:cd17572    1 VLLVEDSPSLAALYQEYLSDEGYKVTHVETGKEALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSLPTSVIVITAHG 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 695764630  88 DVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALAQRQ 125
Cdd:cd17572   81 SVDIAVEAMRLGAYDFLEKPFDADRLRVTVRNALKHRK 118
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
 6-122 1.65e-20

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 86.30  E-value: 1.65e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   6 HNILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITG 85
Cdd:cd17569    1 PTILLVDDEPNILKALKRLLRREGYEVLTATSGEEALEILKQEPVDVVISDQRMPGMDGAELLKRVRERYPDTVRILLTG 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 695764630  86 HGDVPMAVEAVKKGA-WDFLQKPVNPGQLLDLIDKALA 122
Cdd:cd17569   81 YADLDAAIEAINEGEiYRFLTKPWDDEELKETIRQALE 118
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 7-110 4.25e-20

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 85.19  E-value: 4.25e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   7 NILLIDDDSDVLDAYTQLLTQAG-HRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKIL--LKHDPHLPVILI 83
Cdd:cd17551    2 RILIVDDNPTNLLLLEALLRSAGyLEVVSFTDPREALAWCRENPPDLILLDYMMPGMDGLEFIRRLraLPGLEDVPIVMI 81

                         90       100
                 ....*....|....*....|....*..
gi 695764630  84 TGHGDVPMAVEAVKKGAWDFLQKPVNP 110
Cdd:cd17551   82 TADTDREVRLRALEAGATDFLTKPFDP 108
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 7-114 5.49e-20

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 84.80  E-value: 5.49e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   7 NILLIDDDsdvlDAYTQLLTQA----GHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVIL 82
Cdd:cd17563    2 SLLLVDDD----EVFAERLARAlerrGFEVETAHSVEEALALAREEKPDYAVLDLRLGGDSGLDLIPPLRALQPDARIVV 77

                         90       100       110
                 ....*....|....*....|....*....|..
gi 695764630  83 ITGHGDVPMAVEAVKKGAWDFLQKPVNPGQLL 114
Cdd:cd17563   78 LTGYASIATAVEAIKLGADDYLAKPADADEIL 109
PRK15424 PRK15424
propionate catabolism operon regulatory protein PrpR; Provisional
 140-405 1.13e-19

propionate catabolism operon regulatory protein PrpR; Provisional


Pssm-ID: 237963 [Multi-domain]  Cd Length: 538  Bit Score: 90.93  E-value: 1.13e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 140 DNLIGRSEWVTQMRQTLQQLAETDVAVYFHGERGTGRTLAACYLHR--------LSTRGDRPIIF---GDILQGQ-EAPL 207
Cdd:PRK15424 219 GDLLGQSPQMEQVRQTILLYARSSAAVLIQGETGTGKELAAQAIHReyfarhdaRQGKKSHPFVAvncGAIAESLlEAEL 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 208 QAW----------------CEQAQGGTLVLRNIEFLSQAQQLVL-------------AHQQ-AQDeppCRLVATGLQPLI 257
Cdd:PRK15424 299 FGYeegaftgsrrggraglFEIAHGGTLFLDEIGEMPLPLQTRLlrvleekevtrvgGHQPvPVD---VRVISATHCDLE 375

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 258 ALVGNNLILPDLYYCFAMTQQFCPPLAQRLDDIEPLFLHYLQQACLRLNHPVPelPAALAK------KLVNRHWPNNVRE 331
Cdd:PRK15424 376 EDVRQGRFRRDLFYRLSILRLQLPPLRERVADILPLAESFLKQSLAALSAPFS--AALRQGlqqcetLLLHYDWPGNVRE 453

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 332 LANAAKLFAV--GVMPLAEIPNPLLHQVEPMQLDQRVE----DYERQIIIEALNIHQGRINDVSEYLQIPRKKLYLRMKK 405
Cdd:PRK15424 454 LRNLMERLALflSVEPTPDLTPQFLQLLLPELARESAKtpapRLLAATLQQALERFNGDKTAAANYLGISRTTLWRRLKA 533
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 7-145 9.63e-19

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 83.47  E-value: 9.63e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   7 NILLIDDDSDVLDAYTQLLTQAGHRVYA-CGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPhLPVILITG 85
Cdd:COG3707    5 RVLVVDDEPLRRADLREGLREAGYEVVAeAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERP-APVILLTA 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 695764630  86 HGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALAQRQSqvvRRQWQKE--QLEDNLIGR 145
Cdd:COG3707   84 YSDPELIERALEAGVSAYLVKPLDPEDLLPALELALARFRE---LRALRRElaKLREALEER 142
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 8-108 2.37e-18

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 80.32  E-value: 2.37e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITGHG 87
Cdd:cd17555    3 ILVIDDDEVVRESIAAYLEDSGFQVLQAADGRQGLELFRSEQPDLVLCDLRMPEMDGLEVLKQITKESPDTPVIVVSGAG 82

                         90       100
                 ....*....|....*....|.
gi 695764630  88 DVPMAVEAVKKGAWDFLQKPV 108
Cdd:cd17555   83 VMSDAVEALRLGAWDYLTKPI 103
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 8-121 3.50e-18

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 79.59  E-value: 3.50e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGI--VLSDVCMPHCSGIDLLKiLLKHDPHLPVILITG 85
Cdd:cd17584    1 VLVVDDDPTCLAILKRMLLRCGYQVTTCTDAEEALSMLRENKDEFdlVITDVHMPDMDGFEFLE-LIRLEMDLPVIMMSA 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 695764630  86 HGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKAL 121
Cdd:cd17584   80 DGSTSTVMKGLAHGACDYLLKPVSIEDLKNIWQHVV 115
TyrR COG3283
Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid ...
 140-373 8.43e-18

Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid transport and metabolism];


Pssm-ID: 442513 [Multi-domain]  Cd Length: 514  Bit Score: 85.24  E-value: 8.43e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 140 DNLIGRSEwvtQMRQTLQQ---LAETDVAVYFHGERGTGRTL--AACylHRLSTRGDRPII------------------- 195
Cdd:COG3283  204 DHIVASSP---KMRQVIRQakkMAMLDAPLLIQGETGTGKELlaRAC--HLASPRGDKPFLalncaalpddvaeselfgy 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 196 ----FGDILQGQEAPLqawcEQAQGGTLVLRNIEFLS---QAQQL-VL----------AHQQAQDeppCRLVATGLQPLI 257
Cdd:COG3283  279 apgaFGNAREGKKGLF----EQANGGTVFLDEIGEMSpqlQAKLLrFLqdgtfrrvgeEQEVKVD---VRVICATQKDLA 351

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 258 ALVGNNLILPDLYY---CFAMTqqfCPPLAQRLDDIEPLFLHYLQQACLRLNHPVPELPAALAKKLVNRHWPNNVRELAN 334
Cdd:COG3283  352 ELVQEGEFREDLYYrlnVLTLT---LPPLRERKSDILPLAEHFVARFSQQLGRPRPRLSPDLVDFLQSYPWPGNVRQLEN 428

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 695764630 335 AakLF-AVGVM------------PLAEIPNPLLHQVEPMQLDQRVEDYERQI 373
Cdd:COG3283  429 A--LYrAVSLLegdeltpedlqlPEYAASAGLLDDLLEGSLDEIVKRFERSL 478
Sigma54_activ_2 pfam14532
Sigma-54 interaction domain;
143-283 2.30e-17

Sigma-54 interaction domain;


Pssm-ID: 434021 [Multi-domain]  Cd Length: 138  Bit Score: 78.15  E-value: 2.30e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630  143 IGRSEWVTQMRQTLQQLAETDVAVYFHGERGTGRTLAACYLHRLSTRGDRPIifgDILQGQEAPLQaWCEQAQGGTLVLR 222
Cdd:pfam14532   1 LGASAAIQEIKRRLEQAAQSTLPVFLTGEPGSGKEFCARYLHNPSTPWVQPF---DIEYLAHAPLE-LLEQAKGGTLYLK 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 695764630  223 NIEFLSQAQQLVLAHQ-QAQDEPPCRLVATGLQPLIALVGNNLILPDLYYCFAMTQQFCPPL 283
Cdd:pfam14532  77 DIADLSKALQKGLLLLlAKAEGYRVRLVCTSSKDLPQLAAAGLFDEQLYFELSALRLHVPPL 138
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 6-121 3.37e-17

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 76.93  E-value: 3.37e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   6 HNILLIDDDSDVLDAYTQLLTQAGHRVYA-CGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILIT 84
Cdd:cd17542    1 KKVLIVDDAAFMRMMLKDILTKAGYEVVGeAANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKIDPNAKVIMCS 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 695764630  85 GHGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKAL 121
Cdd:cd17542   81 AMGQEEMVKEAIKAGAKDFIVKPFQPERVLEAVEKVL 117
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 8-122 1.36e-16

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 75.24  E-value: 1.36e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLL-TQAGHRVYA-CGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITG 85
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLeSEPDIEVVGeAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVLTA 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 695764630  86 HGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALA 122
Cdd:cd17535   81 HDDPEYVLRALKAGAAGYLLKDSSPEELIEAIRAVAA 117
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 8-124 1.97e-16

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 74.65  E-value: 1.97e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHdPHLPVILITGHG 87
Cdd:cd17623    1 ILLIDDDRELTELLTEYLEMEGFNVRAAHDGEQGLAALLEGSPDLVVLDVMLPKMNGLDVLKELRKT-SQVPVLMLTARG 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 695764630  88 DVPMAVEAVKKGAWDFLQKPVNPGQLLDLIdKALAQR 124
Cdd:cd17623   80 DDIDRILGLELGADDYLPKPFNPRELVARI-RAILRR 115
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 7-127 5.59e-16

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 76.78  E-value: 5.59e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   7 NILLIDDDSDVLDAYTQLLTQAG--HRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILIT 84
Cdd:COG3279    3 KILIVDDEPLARERLERLLEKYPdlEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIFTT 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 695764630  85 GHGDvpMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALAQRQSQ 127
Cdd:COG3279   83 AYDE--YALEAFEVNAVDYLLKPIDEERLAKALEKAKERLEAK 123
REC_RcNtrC-like cd19928
phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C ...
 8-107 1.13e-15

phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C (NtrC) and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include NtrC, also called nitrogen regulator I (NRI), from Rhodobacter capsulatus, Azospirillum brasilense, and Azorhizobium caulinodans. NtrC is part of the NtrB/NtrC two-component system that controls the expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381155 [Multi-domain]  Cd Length: 100  Bit Score: 72.15  E-value: 1.13e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITGHG 87
Cdd:cd19928    1 ILVADDDRAIRTVLTQALGRAGYEVRTTGNAATLWRWVEEGEGDLVITDVVMPDENGLDLIPRIKKARPDLPIIVMSAQN 80

                         90       100
                 ....*....|....*....|
gi 695764630  88 DVPMAVEAVKKGAWDFLQKP 107
Cdd:cd19928   81 TLMTAVKAAERGAFEYLPKP 100
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 8-117 1.22e-15

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 72.49  E-value: 1.22e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDP--HLPVILITG 85
Cdd:cd17580    1 ILVVDDNEDAAEMLALLLELEGAEVTTAHSGEEALEAAQRFRPDVILSDIGMPGMDGYELARRLRELPWlaNTPAIALTG 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 695764630  86 HGDvPMAVEAVKKGAWDF-LQKPVNPGQLLDLI 117
Cdd:cd17580   81 YGQ-PEDRERALEAGFDAhLVKPVDPDELIELI 112
PRK15429 PRK15429
formate hydrogenlyase transcriptional activator FlhA;
136-410 5.95e-15

formate hydrogenlyase transcriptional activator FlhA;


Pssm-ID: 237965 [Multi-domain]  Cd Length: 686  Bit Score: 76.79  E-value: 5.95e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 136 EQLEDN------LIGRSEWVTQMRQTLQQLAETDVAVYFHGERGTGRTLAACYLHRLSTRGDRPII-------------- 195
Cdd:PRK15429 366 EQLNNVdsefgeIIGRSEAMYSVLKQVEMVAQSDSTVLILGETGTGKELIARAIHNLSGRNNRRMVkmncaampaglles 445

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 196 --FGD---ILQGQEAPLQAWCEQAQGGTLVLRNI-EFLSQAQQLVLAHQQAQD----------EPPCRLVATGLQPLIAL 259
Cdd:PRK15429 446 dlFGHergAFTGASAQRIGRFELADKSSLFLDEVgDMPLELQPKLLRVLQEQEferlgsnkiiQTDVRLIAATNRDLKKM 525

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 260 VGNNLILPDLYYCFAMTQQFCPPLAQRLDDIEPLFLHYLQQACLRLNHPVPELPAALAKKLVNRHWPNNVRELANA---A 336
Cdd:PRK15429 526 VADREFRSDLYYRLNVFPIHLPPLRERPEDIPLLVKAFTFKIARRMGRNIDSIPAETLRTLSNMEWPGNVRELENVierA 605

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 337 KLFAVG-----VMPLAEIPNPLLHQVEPmQLDQRVEDyERQIIIEALNIHQGRI---NDVSEYLQIPRKKLYLRMKKFGL 408
Cdd:PRK15429 606 VLLTRGnvlqlSLPDITLPEPETPPAAT-VVAQEGED-EYQLIVRVLKETNGVVagpKGAAQRLGLKRTTLLSRMKRLGI 683


                 ..
gi 695764630 409 DK 410
Cdd:PRK15429 684 DK 685
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 8-108 8.20e-15

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 69.83  E-value: 8.20e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKIlLKHDP---HLPVILIT 84
Cdd:cd17538    2 ILVVDDEPANRELLEALLSAEGYEVLTADSGQEALALAEEELPDLILLDVMMPGMDGFEVCRR-LKEDPetrHIPVIMIT 80

                         90       100
                 ....*....|....*....|....
gi 695764630  85 GHGDVPMAVEAVKKGAWDFLQKPV 108
Cdd:cd17538   81 ALDDREDRIRGLEAGADDFLSKPI 104
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 7-121 1.24e-14

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 69.97  E-value: 1.24e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   7 NILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKiLLKHDP---HLPVILI 83
Cdd:cd17618    2 TILIVEDEPAIREMIAFNLERAGFDVVEAEDAESAVNLIVEPRPDLILLDWMLPGGSGIQFIR-RLKRDEmtrDIPIIML 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 695764630  84 TGHGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIdKAL 121
Cdd:cd17618   81 TARGEEEDKVRGLEAGADDYITKPFSPRELVARI-KAV 117
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 8-108 1.99e-14

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 68.69  E-value: 1.99e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKiLLKHDP---HLPVILIT 84
Cdd:cd19920    1 ILIVDDVPDNLRLLSELLRAAGYRVLVATDGQQALQRAQAEPPDLILLDVMMPGMDGFEVCR-RLKADPatrHIPVIFLT 79

                         90       100
                 ....*....|....*....|....
gi 695764630  85 GHGDVPMAVEAVKKGAWDFLQKPV 108
Cdd:cd19920   80 ALTDTEDKVKGFELGAVDYITKPF 103
psREC_PRR cd17582
pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response ...
 8-107 2.90e-14

pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response regulators (PRRs), also called APRRs, comprise a core group of clock components that controls the pace of the central oscillator of the circadian clock, an endogenous time-keeping mechanism that enables organisms to adapt to external daily cycles. The coordinated sequential expression of PRR9 (APRR9), PRR7 (APRR7), PRR5 (APRR5), PRR3 (APRR3), and PRR1 (APRR1) results in circadian waves that may be at the basis of the endogenous circadian clock. PRRs contain an N-terminal pseudo receiver (psREC) domain that resembles the receiver domain of a two-component response regulator, but lacks an aspartate residue that accepts a phosphoryl group from the sensor kinase, and a CCT motif at the C-terminus that contains a putative nuclear localization signal. The psREC domain is involved in protein-protein interactions.


Pssm-ID: 381120 [Multi-domain]  Cd Length: 104  Bit Score: 68.20  E-value: 2.90e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGI--VLSDVCMPHCSGIDLLKILLKHD--PHLPVILI 83
Cdd:cd17582    1 VLLVENDDSTRQIVTALLRKCSYEVTAASDGLQAWDVLEDEQNEIdlILTEVDLPVSSGFKLLSYIMRHKicKNIPVIMM 80

                         90       100
                 ....*....|....*....|....
gi 695764630  84 TGHGDVPMAVEAVKKGAWDFLQKP 107
Cdd:cd17582   81 SSQDSVGVVFKCLSKGAADYLVKP 104
PRK10820 PRK10820
transcriptional regulator TyrR;
90-335 1.16e-13

transcriptional regulator TyrR;


Pssm-ID: 236769 [Multi-domain]  Cd Length: 520  Bit Score: 72.41  E-value: 1.16e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630  90 PMAVEAVKKGAwDFLQKpVNPGQLLDLIDK-----ALAQRQSQV-VRRQWQKEQLEDN-----LIGRSewvTQMRQTLQQ 158
Cdd:PRK10820 145 SHNEHVVINGQ-DFLME-ITPVYLQDENDQhvlvgAVVMLRSTArMGRQLQNLAVNDDsafsqIVAVS---PKMRQVVEQ 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 159 ---LAETDVAVYFHGERGTGRTLAACYLHRLSTRGDRPII----------------FG-------DILQGQeaplQAWCE 212
Cdd:PRK10820 220 arkLAMLDAPLLITGDTGTGKDLLAYACHLRSPRGKKPFLalncasipddvveselFGhapgaypNALEGK----KGFFE 295

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 213 QAQGGTLVLRNIEFLSQAQQLVL--------------AHQQAQDeppCRLVATGLQPLIALVGNNLILPDLYYCFAMTQQ 278
Cdd:PRK10820 296 QANGGSVLLDEIGEMSPRMQAKLlrflndgtfrrvgeDHEVHVD---VRVICATQKNLVELVQKGEFREDLYYRLNVLTL 372

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 695764630 279 FCPPLAQRLDDIEPLFLHYLQQACLRLNHPVPELPAALAKKLVNRHWPNNVRELANA 335
Cdd:PRK10820 373 NLPPLRDRPQDIMPLTELFVARFADEQGVPRPKLAADLNTVLTRYGWPGNVRQLKNA 429
REC_CpdR_CckA-like cd18160
phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; ...
 8-107 4.20e-13

phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; Two-component systems (TCSs), consisting of a sensor and a response regulator, are used by bacteria to adapt to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis and membrane transport. Response regulators share the common phosphoacceptor REC domain and differ output domains such as DNA, RNA, ligand, and protein-binding, or enzymatic domain. CpdR is a stand-alone REC protein. CckA is a sensor histidine kinase containing N-terminal PAS domains and a C-terminal REC domain. CpdR and CckA are components of a regulatory phosphorelay system (composed of CckA, ChpT, CtrA and CpdR) that controls Brucella abortus cell growth, division, and intracellular survival inside mammalian host cells. CckA autophosphorylates in the presence of ATP and transfers a phosphoryl group to the conserved aspartic acid residue on its C-terminal REC domain, which is relayed to the ChpT phosphotransferase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381144 [Multi-domain]  Cd Length: 103  Bit Score: 65.22  E-value: 4.20e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRA-QDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITGH 86
Cdd:cd18160    2 ILLADDEPSVRKFIVTTLKKAGYAVTEAESGAEAlEKLQQGKDIDIVVTDIVMPEMDGIELAREARKIDPDVKILFISGG 81

                         90       100
                 ....*....|....*....|.
gi 695764630  87 GDVPMAVEAVKKGAWDFLQKP 107
Cdd:cd18160   82 AAAAPELLSDAVGDNATLKKP 102
PRK05022 PRK05022
nitric oxide reductase transcriptional regulator NorR;
120-408 4.74e-13

nitric oxide reductase transcriptional regulator NorR;


Pssm-ID: 235331 [Multi-domain]  Cd Length: 509  Bit Score: 70.59  E-value: 4.74e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 120 ALAQRQSQVVRRQWQKEQLEdnLIGRSEWVTQMRQTLQQLAETDVAVYFHGERGTGRTLAACYLHRLSTRGDRPII---- 195
Cdd:PRK05022 169 AELPQDVAEFLRQEALKEGE--MIGQSPAMQQLKKEIEVVAASDLNVLILGETGVGKELVARAIHAASPRADKPLVylnc 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 196 ------------FGDI---LQGQEAPLQAWCEQAQGGTLVLRNIEFLS---QAQQL-VLAHQQAQ----DEP---PCRLV 249
Cdd:PRK05022 247 aalpeslaeselFGHVkgaFTGAISNRSGKFELADGGTLFLDEIGELPlalQAKLLrVLQYGEIQrvgsDRSlrvDVRVI 326

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 250 ATGLQPLIALVGNNLILPDLYYCFAMTQQFCPPLAQRLDDIEPLFLHYLQQACLRLNhpVPEL---PAALAKkLVNRHWP 326
Cdd:PRK05022 327 AATNRDLREEVRAGRFRADLYHRLSVFPLSVPPLRERGDDVLLLAGYFLEQNRARLG--LRSLrlsPAAQAA-LLAYDWP 403

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 327 NNVRELANA---AKLFAV---------------GVMPLAEIPNPLLHQVEPMQ----LDQRVEDYERQIIIEALNIHQGR 384
Cdd:PRK05022 404 GNVRELEHVisrAALLARargagrivtleaqhlDLPAEVALPPPEAAAAPAAVvsqnLREATEAFQRQLIRQALAQHQGN 483

                        330       340
                 ....*....|....*....|....
gi 695764630 385 INDVSEYLQIPRKKLYLRMKKFGL 408
Cdd:PRK05022 484 WAAAARALELDRANLHRLAKRLGL 507
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 7-88 6.45e-13

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 64.93  E-value: 6.45e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   7 NILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITGH 86
Cdd:cd17554    2 KILVVDDEENIRELYKEELEDEGYEVVTAGNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIREKKPDLPVIICTAY 81


                 ..
gi 695764630  87 GD 88
Cdd:cd17554   82 SE 83
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
 8-107 8.87e-13

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 64.10  E-value: 8.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITGHG 87
Cdd:cd19926    1 VLVVDDEPDIRELLEITLGRMGLDVRSARNVKEARELLASEPYDLCLTDMRLPDGSGLELVQHIQQRLPQTPVAVITAYG 80

                         90       100
                 ....*....|....*....|
gi 695764630  88 DVPMAVEAVKKGAWDFLQKP 107
Cdd:cd19926   81 SLDTAIEALKAGAFDFLTKP 100
pspF PRK11608
phage shock protein operon transcriptional activator; Provisional
 140-386 2.97e-12

phage shock protein operon transcriptional activator; Provisional


Pssm-ID: 236936 [Multi-domain]  Cd Length: 326  Bit Score: 67.00  E-value: 2.97e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 140 DNLIGRSEWVTQMRQTLQQLAETDVAVYFHGERGTGRTLAACYLHRLSTRGDRPII-----------FGDILQGQEAPL- 207
Cdd:PRK11608   6 DNLLGEANSFLEVLEQVSRLAPLDKPVLIIGERGTGKELIASRLHYLSSRWQGPFIslncaalnenlLDSELFGHEAGAf 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 208 -------QAWCEQAQGGTL---------------VLRNIEFlsqaQQL--VLAHQQAQDEppCRLVATGLQPLIALVGNN 263
Cdd:PRK11608  86 tgaqkrhPGRFERADGGTLfldelatapmlvqekLLRVIEY----GELerVGGSQPLQVN--VRLVCATNADLPAMVAEG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630 264 LILPDLYYCFAMTQQFCPPLAQRLDDIEPLFLHYLQQACLRLNHPV-PELPAALAKKLVNRHWPNNVRELANAAK----- 337
Cdd:PRK11608 160 KFRADLLDRLAFDVVQLPPLRERQSDIMLMAEHFAIQMCRELGLPLfPGFTERARETLLNYRWPGNIRELKNVVErsvyr 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695764630 338 -------LFAVGVMPLAEIPNPLLHQVE--------PMQLDQRVEDYERQIIIEALNihQGRIN 386
Cdd:PRK11608 240 hgtseypLDNIIIDPFKRRPAEEAIAVSettslptlPLDLREWQHQQEKELLQRSLQ--QAKFN 301
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 8-117 5.77e-12

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 62.10  E-value: 5.77e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHD---PHLPVILIT 84
Cdd:cd17546    1 VLVVDDNPVNRKVLKKLLEKLGYEVDVAENGQEALELLKEEPFDLVLMDLQMPVMDGLEATRRIRELEgggRRTPIIALT 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 695764630  85 GHGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLI 117
Cdd:cd17546   81 ANALEEDREKCLEAGMDDYLSKPVKLDQLKEVL 113
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 8-121 2.46e-11

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 60.39  E-value: 2.46e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPH--LPVILITG 85
Cdd:cd17562    3 ILAVDDSASIRQMVSFTLRGAGYEVVEAADGRDALSKAQSKKFDLIITDQNMPNMDGIELIKELRKLPAYkfTPILMLTT 82

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 695764630  86 HGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKAL 121
Cdd:cd17562   83 ESSDEKKQEGKAAGATGWLVKPFDPEQLLEVVKKVL 118
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 7-119 4.50e-11

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 59.71  E-value: 4.50e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   7 NILLIDDDSDVLDAYTQLLTQA-GHRV--YAcGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPhLPVILI 83
Cdd:cd17541    2 RVLIVDDSAVMRKLLSRILESDpDIEVvgTA-RDGEEALEKIKELKPDVITLDIEMPVMDGLEALRRIMAERP-TPVVMV 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 695764630  84 TGH--GDVPMAVEAVKKGAWDFLQKPVNPGQLL------DLIDK 119
Cdd:cd17541   80 SSLteEGAEITLEALELGAVDFIAKPSGGISLDleeiaeELIEK 123
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 8-119 4.74e-11

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 59.38  E-value: 4.74e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKiLLKHDPHLPVILITGHG 87
Cdd:cd17594    2 VLVVDDDAAMRHLLILYLRERGFDVTAAADGAEEARLMLHRRVDLVLLDLRLGQESGLDLLR-TIRARSDVPIIIISGDR 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 695764630  88 DVPMA-VEAVKKGAWDFLQKPVNPGQLLDLIDK 119
Cdd:cd17594   81 RDEIDrVVGLELGADDYLAKPFGLRELLARVRA 113
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 8-121 4.84e-11

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 59.49  E-value: 4.84e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITGHG 87
Cdd:cd17553    3 ILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVTKERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAYG 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 695764630  88 DVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKAL 121
Cdd:cd17553   83 ELDMIQESKELGALTHFAKPFDIDEIRDAVKKYL 116
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
6-146 5.69e-11

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 62.13  E-value: 5.69e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   6 HNILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWpGIVLSDVCMPHCSGIDLLKILLKHDpHLPVILITG 85
Cdd:PRK10955   2 NKILLVDDDRELTSLLKELLEMEGFNVIVAHDGEQALDLLDDSI-DLLLLDVMMPKKNGIDTLKELRQTH-QTPVIMLTA 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 695764630  86 HGDVPMAVEAVKKGAWDFLQKPVNpgqlldliDKALAQRQSQVVRRQWQKEQLEDNLIGRS 146
Cdd:PRK10955  80 RGSELDRVLGLELGADDYLPKPFN--------DRELVARIRAILRRSHWSEQQQNNDNGSP 132
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 8-123 7.17e-11

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 59.35  E-value: 7.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYA-CGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPhLPVILITGH 86
Cdd:cd19932    3 VLIAEDEALIRMDLREMLEEAGYEVVGeASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENI-APIVLLTAY 81

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 695764630  87 GDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALAQ 123
Cdd:cd19932   82 SQQDLVERAKEAGAMAYLVKPFSESDLIPAIEMAIAR 118
REC_HupR cd17596
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of ...
 8-127 7.40e-11

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of this subfamily are response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It belongs to the nitrogen regulatory protein C (NtrC) family of response regulators, which activate transcription by RNA polymerase (RNAP) in response to a change in the environment. HupR is an unusual member of this family as it activates transcription when unphosphorylated, and transcription is inhibited by phosphorylation. Proteins in this subfamily contain an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381127 [Multi-domain]  Cd Length: 133  Bit Score: 59.69  E-value: 7.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLtQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITGHG 87
Cdd:cd17596    3 ILVVDDEVRSLEALRRTL-EEDFDVLTAASAEEALAILEEEWVQVILCDQRMPGTTGVEFLKEVRERWPEVVRIIISGYT 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 695764630  88 DVPMAVEAVKK-GAWDFLQKPVNPGQLLDLIDKALAQRQSQ 127
Cdd:cd17596   82 DSEDIIAGINEaGIYQYLTKPWHPDQLLLTVRNAARLFELQ 122
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 7-121 1.14e-10

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 58.50  E-value: 1.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   7 NILLIDDDSDVLDAYTQLLTQAGHR-VYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKIL-----LKHdphLPV 80
Cdd:cd19923    2 KVLVVDDFSTMRRIIKNLLKELGFNnVEEAEDGVDALEKLKAGGFDFVITDWNMPNMDGLELLKTIradgaLSH---LPV 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 695764630  81 ILITGHGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKAL 121
Cdd:cd19923   79 LMVTAEAKKENVIAAAQAGVNNYIVKPFTAATLKEKLEKIF 119
Sigma54_activat pfam00158
Sigma-54 interaction domain;
142-271 2.70e-10

Sigma-54 interaction domain;


Pssm-ID: 425491 [Multi-domain]  Cd Length: 168  Bit Score: 58.95  E-value: 2.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630  142 LIGRSEWVTQMRQTLQQLAETDVAVYFHGERGTGRTLAACYLHRLSTRGDRPIIF---GDI--------LQGQEAplQA- 209
Cdd:pfam00158   1 IIGESPAMQEVLEQAKRVAPTDAPVLITGESGTGKELFARAIHQLSPRADGPFVAvncAAIpeelleseLFGHEK--GAf 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630  210 ---------WCEQAQGGTLVLRNIEFLSQAQQ--L--VLAHQQ-----AQDEPP--CRLVATGLQPLIALVGNNLILPDL 269
Cdd:pfam00158  79 tgadsdrkgLFELADGGTLFLDEIGELPLELQakLlrVLQEGEfervgGTKPIKvdVRIIAATNRDLEEAVAEGRFREDL 158


                  ..
gi 695764630  270 YY 271
Cdd:pfam00158 159 YY 160
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 7-119 3.40e-10

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 57.16  E-value: 3.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   7 NILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKiLLKHDP---HLPVILI 83
Cdd:cd17548    1 KILIVEDNPLNMKLARDLLESAGYEVLEAADGEEALEIARKEKPDLILMDIQLPGMDGLEATR-LLKEDPatrDIPVIAL 79

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 695764630  84 TGH---GDVPMAVEAvkkGAWDFLQKPVNPGQLLDLIDK 119
Cdd:cd17548   80 TAYamkGDREKILEA---GCDGYISKPIDTREFLETVAK 115
REC_PatA-like cd17602
phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) ...
 8-107 5.67e-10

phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.


Pssm-ID: 381129 [Multi-domain]  Cd Length: 102  Bit Score: 56.22  E-value: 5.67e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHD--PHLPVILITG 85
Cdd:cd17602    1 VACVDDRPSIQKMIEYFLEKQGFRVVVIDDPLRALTTLLNSKPDLILIDIDMPDLDGYELCSLLRKSSalKDTPIIMLTG 80

                         90       100
                 ....*....|....*....|..
gi 695764630  86 HGDVPMAVEAVKKGAWDFLQKP 107
Cdd:cd17602   81 KDGLVDRIRAKMAGASGYLTKP 102
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 7-108 6.27e-10

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 56.48  E-value: 6.27e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   7 NILLIDDDSDVLDAYTQLLTQAG--HRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILIT 84
Cdd:cd19925    2 NVLIVEDDPMVAEIHRAYVEQVPgfTVIGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVIVVT 81

                         90       100
                 ....*....|....*....|....
gi 695764630  85 GHGDVPMAVEAVKKGAWDFLQKPV 108
Cdd:cd19925   82 AANDVETVREALRLGVVDYLIKPF 105
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 9-124 8.76e-10

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 56.08  E-value: 8.76e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   9 LLIDDDSDVLDAYTQLLTQAGHRVYACGDplrAQDLVSEAWPGI---VLSDVCMPHCSGIDLLKILLKHDPHLPVILITG 85
Cdd:cd17625    1 LVVEDEKDLSEAITKHLKKEGYTVDVCFD---GEEGLEYALSGIydlIILDIMLPGMDGLEVLKSLREEGIETPVLLLTA 77

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 695764630  86 HGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIdKALAQR 124
Cdd:cd17625   78 LDAVEDRVKGLDLGADDYLPKPFSLAELLARI-RALLRR 115
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 8-107 1.03e-09

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 55.14  E-value: 1.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITGHG 87
Cdd:cd19935    1 ILVVEDEKKLAEYLKKGLTEEGYAVDVAYDGEDGLHLALTNEYDLIILDVMLPGLDGLEVLRRLRAAGKQTPVLMLTARD 80

                         90       100
                 ....*....|....*....|
gi 695764630  88 DVPMAVEAVKKGAWDFLQKP 107
Cdd:cd19935   81 SVEDRVKGLDLGADDYLVKP 100
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 8-107 1.18e-09

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 55.08  E-value: 1.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKiLLKHDP---HLPVILIT 84
Cdd:cd19927    1 ILLVDDDPGIRLAVKDYLEDQGFTVIAASNGLEALDLLNQYIPDLIISDIIMPGVDGYSLLG-KLRKNAdfdTIPVIFLT 79

                         90       100
                 ....*....|....*....|...
gi 695764630  85 GHGDVPMAVEAVKKGAWDFLQKP 107
Cdd:cd19927   80 AKGMTSDRIKGYNAGCDGYLSKP 102
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
 8-107 3.72e-09

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 53.60  E-value: 3.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKiLLKHDPHLPVILITGHG 87
Cdd:cd19936    1 IALVDDDRNILTSVSMALEAEGFSVETYTDGASALDGLNARPPDLAILDIKMPRMDGMELLQ-RLRQKSTLPVIFLTSKD 79

                         90       100
                 ....*....|....*....|
gi 695764630  88 DVPMAVEAVKKGAWDFLQKP 107
Cdd:cd19936   80 DEIDEVFGLRMGADDYITKP 99
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 8-124 4.02e-09

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 53.93  E-value: 4.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITGHG 87
Cdd:cd17627    1 ILVVDDDRAVRESLRRSLRFEGYEVETAVDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAAGNDLPILVLTARD 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 695764630  88 DVPMAVEAVKKGAWDFLQKPVNPGQLLDLIdKALAQR 124
Cdd:cd17627   81 SVSDRVAGLDAGADDYLVKPFALEELLARV-RALLRR 116
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 8-114 4.15e-09

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 54.01  E-value: 4.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKiLLKHDPHLPVILITGHG 87
Cdd:cd17626    3 ILVVDDDAALAEMIGIVLRGEGFDPAFCGDGTQALAAFREVRPDLVLLDLMLPGIDGIEVCR-QIRAESGVPIVMLTAKS 81

                         90       100
                 ....*....|....*....|....*..
gi 695764630  88 DVPMAVEAVKKGAWDFLQKPVNPGQLL 114
Cdd:cd17626   82 DTVDVVLGLESGADDYVAKPFKPKELV 108
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 6-110 4.46e-09

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 54.06  E-value: 4.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   6 HNILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVsEAWPGI--VLSDVCMPHCSGIDLLK-ILLKHDPH-LPVI 81
Cdd:cd17544    1 IKVLVVDDSATSRNHLRALLRRHNFQVLEAANGQEALEVL-EQHPDIklVITDYNMPEMDGFELVReIRKKYSRDqLAII 79

                         90       100
                 ....*....|....*....|....*....
gi 695764630  82 LITGHGDVPMAVEAVKKGAWDFLQKPVNP 110
Cdd:cd17544   80 GISASGDNALSARFIKAGANDFLTKPFLP 108
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
8-126 5.47e-09

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 56.27  E-value: 5.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKH--DPHLPVILITG 85
Cdd:PRK10161   5 ILVVEDEAPIREMVCFVLEQNGFQPVEAEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIKHLKREsmTRDIPVVMLTA 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 695764630  86 HGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIdKALAQRQS 126
Cdd:PRK10161  85 RGEEEDRVRGLETGADDYITKPFSPKELVARI-KAVMRRIS 124
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 8-156 9.38e-09

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 55.32  E-value: 9.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITGHG 87
Cdd:PRK09836   3 LLIVEDEKKTGEYLTKGLTEAGFVVDLADNGLNGYHLAMTGDYDLIILDIMLPDVNGWDIVRMLRSANKGMPILLLTALG 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 695764630  88 DVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALAQRQSQVVRRQWQKEQLEDNLIGRSEWVTQMRQTL 156
Cdd:PRK09836  83 TIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRGAAVIIESQFQVADLMVDLVSRKVTRSGTRITL 151
PRK15479 PRK15479
transcriptional regulator TctD;
8-132 2.03e-08

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 54.34  E-value: 2.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRA-QDLVSEAWPGIVLsDVCMPHCSGIDLLKILLKHDPHLPVILITGH 86
Cdd:PRK15479   3 LLLAEDNRELAHWLEKALVQNGFAVDCVFDGLAAdHLLQSEMYALAVL-DINMPGMDGLEVLQRLRKRGQTLPVLLLTAR 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 695764630  87 GDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALAQRQSQVVRRQ 132
Cdd:PRK15479  82 SAVADRVKGLNVGADDYLPKPFELEELDARLRALLRRSAGQVQEVQ 127
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 8-60 2.34e-08

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 49.87  E-value: 2.34e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 695764630     8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMP 60
Cdd:smart00448   3 ILVVDDDPLLRELLKALLEKEGYEVDEATDGEEALELLKEEKPDLILLDIMMP 55
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 8-107 3.63e-08

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 51.33  E-value: 3.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITGHG 87
Cdd:cd17624    1 ILLVEDDALLGDGLKTGLRKAGYAVDWVRTGAEAEAALASGPYDLVILDLGLPDGDGLDLLRRWRRQGQSLPVLILTARD 80

                         90       100
                 ....*....|....*....|
gi 695764630  88 DVPMAVEAVKKGAWDFLQKP 107
Cdd:cd17624   81 GVDDRVAGLDAGADDYLVKP 100
ompR PRK09468
osmolarity response regulator; Provisional
 1-129 4.39e-08

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 53.44  E-value: 4.39e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   1 MLTDHHNILLIDDD---SDVLDAYtqlLTQAGHRVYACGDPlRAQD--LVSEAWPGIVLsDVCMPHCSGIDLLKILLKHD 75
Cdd:PRK09468   1 MMQENYKILVVDDDmrlRALLERY---LTEQGFQVRSAANA-EQMDrlLTRESFHLMVL-DLMLPGEDGLSICRRLRSQN 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 695764630  76 PHLPVILITGHGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIdKALAQRQSQVV 129
Cdd:PRK09468  76 NPTPIIMLTAKGEEVDRIVGLEIGADDYLPKPFNPRELLARI-RAVLRRQAPEL 128
pleD PRK09581
response regulator PleD; Reviewed
 8-114 6.33e-08

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 54.52  E-value: 6.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDD-DSDV--LDAytQLLTQAgHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKiLLKHDP---HLPVI 81
Cdd:PRK09581   5 ILVVDDiPANVklLEA--KLLAEY-YTVLTASSGAEAIAICEREQPDIILLDVMMPGMDGFEVCR-RLKSDPattHIPVV 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 695764630  82 LITGHGDVPMAVEAVKKGAWDFLQKPVNPGQLL 114
Cdd:PRK09581  81 MVTALDDPEDRVRGLEAGADDFLTKPINDVALF 113
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 8-107 7.96e-08

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 50.43  E-value: 7.96e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITGHG 87
Cdd:cd17615    2 VLVVDDEPNITELLSMALRYEGWDVETAADGAEALAAAREFRPDAVVLDIMLPDMDGLEVLRRLRADGPDVPVLFLTAKD 81

                         90       100
                 ....*....|....*....|
gi 695764630  88 DVPMAVEAVKKGAWDFLQKP 107
Cdd:cd17615   82 SVEDRIAGLTAGGDDYVTKP 101
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 8-124 8.04e-08

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 50.45  E-value: 8.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDpHLPVILITGHG 87
Cdd:cd19939    2 ILIVEDELELARLTRDYLIKAGLEVSVFTDGQRAVRRIIDEQPSLVVLDIMLPGMDGLTVCREVREHS-HVPILMLTART 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 695764630  88 DVPMAVEAVKKGAWDFLQKPVNPGQLLDLIdKALAQR 124
Cdd:cd19939   81 EEMDRVLGLEMGADDYLCKPFSPRELLARV-RALLRR 116
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 7-117 9.89e-08

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 50.49  E-value: 9.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   7 NILLIDDDSDvlDAytQLLTQA------GHRVYACGDP------LRAQDLVSEA-WPGIVLSDVCMPHCSGIDLLKIlLK 73
Cdd:cd17557    1 TILLVEDNPG--DA--ELIQEAfkeagvPNELHVVRDGeealdfLRGEGEYADApRPDLILLDLNMPRMDGFEVLRE-IK 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 695764630  74 HDPHL---PVILIT---GHGDVpmaVEAVKKGAWDFLQKPVNPGQLLDLI 117
Cdd:cd17557   76 ADPDLrriPVVVLTtsdAEEDI---ERAYELGANSYIVKPVDFEEFVEAI 122
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 35-125 1.97e-07

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 49.46  E-value: 1.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630  35 CGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKIL--LKHDPHlpVILITGHGDvpMAVEAVKKGAWDFLQKPVNPGQ 112
Cdd:cd17532   30 AENGEEALEAIEELKPDVVFLDIQMPGLDGLELAKKLskLAKPPL--IVFVTAYDE--YAVEAFELNAVDYLLKPFSEER 105

                         90
                 ....*....|...
gi 695764630 113 LLDLIDKALAQRQ 125
Cdd:cd17532  106 LAEALAKLRKRLS 118
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
 17-117 2.27e-07

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 49.25  E-value: 2.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630  17 VLDAYTQ------LLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKiLLKHDP---HLPVILITGHG 87
Cdd:cd17598    4 VEDSPTQaeqlkhILEEQGYKVQVARNGREALAMLAEHRPTLVISDIVMPEMDGYELCR-KIKSDPdlkDIPVILLTTLS 82

                         90       100       110
                 ....*....|....*....|....*....|
gi 695764630  88 DVPMAVEAVKKGAWDFLQKPVNPGQLLDLI 117
Cdd:cd17598   83 DPRDVIRGLECGADNFITKPYDEKYLLSRI 112
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 7-72 2.36e-07

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 49.51  E-value: 2.36e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 695764630   7 NILLIDDDSDVLDAYTQLLTQAG--HRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILL 72
Cdd:COG2197    3 RVLIVDDHPLVREGLRALLEAEPdiEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRLL 70
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 9-119 2.70e-07

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 49.07  E-value: 2.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   9 LLIDDDSDVldAYTQLL----TQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILIT 84
Cdd:cd17593    3 VLICDDSSM--ARKQLAralpADWDVEITFAENGEEALEILREGRIDVLFLDLTMPVMDGYEVLEALPVEQLETKVIVVS 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 695764630  85 GhgDV-PMAVEAVKK-GAWDFLQKPVNPGQLLDLIDK 119
Cdd:cd17593   81 G--DVqPEAKERVLElGALAFLKKPFDPEKLAQLLEE 115
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
 8-108 2.90e-07

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 48.50  E-value: 2.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLV-SEAWPGIVLSDVCMP-HCSGIDLLKILLKHDPHLPVILITG 85
Cdd:cd18161    1 VLVVEDDPDVRRLTAEVLEDLGYTVLEAASGDEALDLLeSGPDIDLLVTDVIMPgGMNGSQLAEEARRRRPDLKVLLTSG 80

                         90       100
                 ....*....|....*....|...
gi 695764630  86 HGDVPMAVEAVKKGAWdFLQKPV 108
Cdd:cd18161   81 YAENAIEGGDLAPGVD-VLSKPF 102
orf27 CHL00148
Ycf27; Reviewed
 1-113 5.74e-07

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 50.49  E-value: 5.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   1 MLTDHHNILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKhDPHLPV 80
Cdd:CHL00148   2 MENSKEKILVVDDEAYIRKILETRLSIIGYEVITASDGEEALKLFRKEQPDLVILDVMMPKLDGYGVCQEIRK-ESDVPI 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 695764630  81 ILITGHGDVPMAVEAVKKGAWDFLQKPVNPGQL 113
Cdd:CHL00148  81 IMLTALGDVSDRITGLELGADDYVVKPFSPKEL 113
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 8-122 8.52e-07

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 47.65  E-value: 8.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAG--HRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITG 85
Cdd:cd19930    1 VLIAEDQEMVRGALAALLELEDdlEVVAQASNGQEALRLVLKHSPDVAILDIEMPGRTGLEVAAELREELPDTKVLIVTT 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 695764630  86 HGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALA 122
Cdd:cd19930   81 FGRPGYFRRALAAGVDGYVLKDRPIEELADAIRTVHA 117
dpiA PRK10046
two-component response regulator DpiA; Provisional
 2-203 8.65e-07

two-component response regulator DpiA; Provisional


Pssm-ID: 182208 [Multi-domain]  Cd Length: 225  Bit Score: 49.63  E-value: 8.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   2 LTDHHNILLIDDDSDVLDAYTQLLTQ--AGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKhdPHLP 79
Cdd:PRK10046   1 MTAPLTLLIVEDETPLAEMHAEYIRHipGFSQILLAGNLAQARMMIERFKPGLILLDNYLPDGRGINLLHELVQ--AHYP 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630  80 --VILITGHGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALAQRQSQVVRRQWQKEQLED--NLIGRSEWVTQMRQT 155
Cdd:PRK10046  79 gdVVFTTAASDMETVSEAVRCGVFDYLIKPIAYERLGQTLTRFRQRKHMLESIDSASQKQIDEmfNAYARGEPKDELPTG 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 695764630 156 LQQLAETDVAVYFH--GERGTGRTLA-ACYLHRLSTR------GDRPIIFGDILQGQ 203
Cdd:PRK10046 159 IDPLTLNAVRKLFKepGVQHTAETVAqALTISRTTARryleycASRHLIIAEIVHGK 215
HTH_8 pfam02954
Bacterial regulatory protein, Fis family;
366-405 1.17e-06

Bacterial regulatory protein, Fis family;


Pssm-ID: 427077 [Multi-domain]  Cd Length: 40  Bit Score: 44.69  E-value: 1.17e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 695764630  366 VEDYERQIIIEALNIHQGRINDVSEYLQIPRKKLYLRMKK 405
Cdd:pfam02954   1 LEEVEKELIEAALERTGGNKSKAARLLGISRRTLYRKLKK 40
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 8-114 1.28e-06

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 46.89  E-value: 1.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITGHG 87
Cdd:cd19934    1 LLLVEDDALLAAQLKEQLSDAGYVVDVAEDGEEALFQGEEEPYDLVVLDLGLPGMDGLSVLRRWRSEGRATPVLILTARD 80

                         90       100
                 ....*....|....*....|....*..
gi 695764630  88 DVPMAVEAVKKGAWDFLQKPVNPGQLL 114
Cdd:cd19934   81 SWQDKVEGLDAGADDYLTKPFHIEELL 107
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 7-121 2.02e-06

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 46.25  E-value: 2.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   7 NILLIDDDSDVLDAYTQLLTQAGHRVyaCGDPLRAQD---LVSEAWPGIVLSDVCMP-HCSGIDLLKILLKHdPHLPVIL 82
Cdd:cd17534    2 KILIVEDEAIIALDLKEILESLGYEV--VGIADSGEEaieLAEENKPDLILMDINLKgDMDGIEAAREIREK-FDIPVIF 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 695764630  83 ITGHGDVPMaVEAVKK-GAWDFLQKPVNPGQLLDLIDKAL 121
Cdd:cd17534   79 LTAYSDEET-LERAKEtNPYGYLVKPFNERELKAAIELAL 117
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 8-124 2.54e-06

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 46.26  E-value: 2.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDpHLPVILITGHG 87
Cdd:cd17614    1 ILVVDDEKPISDILKFNLTKEGYEVVTAYDGREALEKVEEEQPDLILLDLMLPEKDGLEVCREVRKTS-NVPIIMLTAKD 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 695764630  88 DVPMAVEAVKKGAWDFLQKPVNPGQLLDLIdKALAQR 124
Cdd:cd17614   80 SEVDKVLGLELGADDYVTKPFSNRELLARV-KANLRR 115
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
32-131 3.93e-06

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 48.61  E-value: 3.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630  32 VYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPhLPVILI---TGHG-DVPMavEAVKKGAWDFLQKP 107
Cdd:PRK00742  32 VGTAPDGLEAREKIKKLNPDVITLDVEMPVMDGLDALEKIMRLRP-TPVVMVsslTERGaEITL--RALELGAVDFVTKP 108

                         90       100       110
                 ....*....|....*....|....*....|..
gi 695764630 108 VNPGQL------LDLIDK--ALAQRQSQVVRR 131
Cdd:PRK00742 109 FLGISLgmdeykEELAEKvrAAARARVRALPP 140
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
 8-107 4.71e-06

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 44.88  E-value: 4.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKiLLKHDPHLPVILITGHG 87
Cdd:cd17621    1 VLVVEDEESFSDPLAYLLRKEGFEVTVATDGPAALAEFDRAGADIVLLDLMLPGLSGTEVCR-QLRARSNVPVIMVTAKD 79

                         90       100
                 ....*....|....*....|
gi 695764630  88 DVPMAVEAVKKGAWDFLQKP 107
Cdd:cd17621   80 SEIDKVVGLELGADDYVTKP 99
PRK10360 PRK10360
transcriptional regulator UhpA;
8-138 5.20e-06

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 46.89  E-value: 5.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLT-QAGHRVYACGDPLRaqdlvsEAWPG-------IVLSDVCMPHCSGIDLLKILLKhdpHLP 79
Cdd:PRK10360   4 VALIDDHLIVRSGFAQLLGlEPDLQVVAEFGSGR------EALAGlpgrgvqVCICDISMPDISGLELLSQLPK---GMA 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 695764630  80 VILITGHgDVPMAVE-AVKKGAWDFLQKPVNPGQLL---------------DLIDKALAQRQSQVVRRQWQKEQL 138
Cdd:PRK10360  75 TIMLSVH-DSPALVEqALNAGARGFLSKRCSPDELIaavhtvatggcyltpDIAIKLASGRQDPLTKRERQVAEK 148
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 8-107 6.75e-06

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 44.46  E-value: 6.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDpHLPVILITGHG 87
Cdd:cd17620    1 ILVIEDEPQIRRFLRTALEAHGYRVFEAETGQEGLLEAATRKPDLIILDLGLPDMDGLEVIRRLREWS-AVPVIVLSARD 79

                         90       100
                 ....*....|....*....|
gi 695764630  88 DVPMAVEAVKKGAWDFLQKP 107
Cdd:cd17620   80 EESDKIAALDAGADDYLTKP 99
PRK15347 PRK15347
two component system sensor kinase;
8-125 1.00e-05

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 47.71  E-value: 1.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKiLLKH-----DPHLPVIL 82
Cdd:PRK15347 693 ILLVDDVETNRDIIGMMLVELGQQVTTAASGTEALELGRQHRFDLVLMDIRMPGLDGLETTQ-LWRDdpnnlDPDCMIVA 771

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 695764630  83 ITGHGdVPMAVEAVKK-GAWDFLQKPVNPGQLLDLIDKAlAQRQ 125
Cdd:PRK15347 772 LTANA-APEEIHRCKKaGMNHYLTKPVTLAQLARALELA-AEYQ 813
PRK10430 PRK10430
two-component system response regulator DcuR;
7-146 2.31e-05

two-component system response regulator DcuR;


Pssm-ID: 182454 [Multi-domain]  Cd Length: 239  Bit Score: 45.48  E-value: 2.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   7 NILLIDDDSDVLDAYTQLLTQ-AGHRVYACGDPL-RAQDLVSEAWPGI--VLSDVCMPHCSGIDLLKILLKHDPHLPVIL 82
Cdd:PRK10430   3 NVLIVDDDAMVAELNRRYVAQiPGFQCCGTASTLeQAKEIIFNSDTPIdlILLDIYMQQENGLDLLPVLHEAGCKSDVIV 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 695764630  83 ITGHGDVPMAVEAVKKGAWDFLQKPVNPGQLldliDKALA---QRQSQVVRRQWQKEQLEDNLIGRS 146
Cdd:PRK10430  83 ISSAADAATIKDSLHYGVVDYLIKPFQASRF----EEALTgwrQKKMALEKHQYYDQAELDQLIHGS 145
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 7-110 2.49e-05

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 45.34  E-value: 2.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   7 NILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITGH 86
Cdd:PRK11083   5 TILLVEDEQAIADTLVYALQSEGFTVEWFERGLPALDKLRQQPPDLVILDVGLPDISGFELCRQLLAFHPALPVIFLTAR 84

                         90       100
                 ....*....|....*....|....
gi 695764630  87 GDVPMAVEAVKKGAWDFLQKPVNP 110
Cdd:PRK11083  85 SDEVDRLVGLEIGADDYVAKPFSP 108
pleD PRK09581
response regulator PleD; Reviewed
 7-142 2.79e-05

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 46.05  E-value: 2.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   7 NILLIDDDSDVLDAYTQLLTQAgHRVYACGDPLRAQDLVSEAWPGIVLSDVcmpHCSGIDLLKI--LLKHDP---HLPVI 81
Cdd:PRK09581 157 RILLVDDDVSQAERIANILKEE-FRVVVVSDPSEALFNAAETNYDLVIVSA---NFENYDPLRLcsQLRSKErtrYVPIL 232

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 695764630  82 LITGHGDVPMAVEAVKKGAWDFLQKPVNPGQLldlidkaLAQRQSQVVRRQWQkEQLEDNL 142
Cdd:PRK09581 233 LLVDEDDDPRLVKALELGVNDYLMRPIDKNEL-------LARVRTQIRRKRYQ-DALRNNL 285
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 8-117 4.48e-05

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 42.40  E-value: 4.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITGHG 87
Cdd:cd17616    1 VLLIEDDSATAQSIELMLKSEGFNVYTTDLGEEGLDLGKLYDYDIILLDLNLPDMSGYEVLRTLRLAKVKTPILILSGLA 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 695764630  88 DVPMAVEAVKKGAWDFLQKPVNPGQLLDLI 117
Cdd:cd17616   81 DIEDKVKGLGFGADDYMTKPFHKDELVARI 110
REC_WspR-like cd17575
phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The ...
 8-106 4.49e-05

phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The GGDEF response regulator WspR is part of the Wsp system that is homologous to chemotaxis systems and also includes the membrane-bound receptor protein WspA. In response to growth on surfaces, WspR is phosphorylated by the Wsp signal transduction complex and is activated, functioning as a diguanylate cyclase (DGC) that catalyzes c-di-GMP synthesis. WspR is a hybrid response regulator-diguanylate cyclase, containing an N-terminal REC domain and a C-terminal GGDEF domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381117 [Multi-domain]  Cd Length: 128  Bit Score: 42.78  E-value: 4.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLT-QAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDP--HLPVILIT 84
Cdd:cd17575    3 VLLVDDQAIIGEAVRRALAdEEDIDFHYCSDPTEAIEVASQIKPTVILQDLVMPGVDGLTLVRFFRANPAtrDIPIIVLS 82

                         90       100
                 ....*....|....*....|..
gi 695764630  85 GHGDVPMAVEAVKKGAWDFLQK 106
Cdd:cd17575   83 TKEEPEVKSEAFALGANDYLVK 104
REC_PhyR cd17540
phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is ...
 8-122 4.65e-05

phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is a hybrid stress regulator that contains an N-terminal sigma-like (SL) domain and a C-terminal REC domain. Phosphorylation of the REC domain is known to promote binding of the SL domain to an anti-sigma factor. PhyR thus functions as an anti-anti-sigma factor in its phosphorylated state. It is involved in the general stress response. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381095 [Multi-domain]  Cd Length: 117  Bit Score: 42.62  E-value: 4.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVyaCGDPL---RAQDLVSEAWPGIVLSDVCMPH-CSGIDLLK-ILLKHDPhlPVIL 82
Cdd:cd17540    3 VLIIEDEPLIAMDLEQIVEDLGHQV--VGIARtrdEAVALARRERPDLILADIQLADgSSGIDAVNeILTTHDV--PVIF 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 695764630  83 ITGHgdvPmavEAVKKGAW---DFL-QKPVNPGQLLDLIDKALA 122
Cdd:cd17540   79 VTAY---P---ERLLTGERpepTFLiTKPFDPEMVKAAISQALF 116
PRK11517 PRK11517
DNA-binding response regulator HprR;
8-123 5.15e-05

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 44.12  E-value: 5.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILlKHDPHLPVILITGHG 87
Cdd:PRK11517   3 ILLIEDNQRTQEWVTQGLSEAGYVIDAVSDGRDGLYLALKDDYALIILDIMLPGMDGWQILQTL-RTAKQTPVICLTARD 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 695764630  88 DVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALAQ 123
Cdd:PRK11517  82 SVDDRVRGLDSGANDYLVKPFSFSELLARVRAQLRQ 117
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
2-186 6.15e-05

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 45.50  E-value: 6.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630    2 LTDHHNILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVI 81
Cdd:PRK09959  955 LPEKLSILIADDHPTNRLLLKRQLNLLGYDVDEATDGVQALHKVSMQHYDLLITDVNMPNMDGFELTRKLREQNSSLPIW 1034

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   82 LITGHGDVPMAVEAVKKGAWDFLQKPVNpgqlLDLIDKALAQRQsQVVR-----RQWQKEQLEDNLIGRSEWVTQMRQTL 156
Cdd:PRK09959 1035 GLTANAQANEREKGLSCGMNLCLFKPLT----LDVLKTHLSQLH-QVAHiapqyRHLDIEALKNNTANDLQLMQEILMTF 1109

                         170       180       190
                  ....*....|....*....|....*....|.
gi 695764630  157 QQLAETDVAVYFHG-ERGTGRTLAACyLHRL 186
Cdd:PRK09959 1110 QHETHKDLPAAFHAlEAGDNRTFHQC-IHRI 1139
FleQ pfam06490
Flagellar regulatory protein FleQ; This domain is found at the N terminus of a subset of ...
 7-117 7.21e-05

Flagellar regulatory protein FleQ; This domain is found at the N terminus of a subset of sigma54-dependent transcriptional activators that are involved in regulation of flagellar motility e.g. FleQ in Pseudomonas aeruginosa. It is clearly related to pfam00072, but lacks the conserved aspartate residue that undergoes phosphorylation in the classic two-component system response regulator (pfam00072).


Pssm-ID: 428975 [Multi-domain]  Cd Length: 108  Bit Score: 41.79  E-value: 7.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630    7 NILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVcmpHCSGIDLLKILLKHDPHLPVILITGH 86
Cdd:pfam06490   1 KILVIDDDAERRHDLSTILEFLGEQCEAISSEDLSAALWSSRWEALAVILG---SVSAAELLKALAKWDPHLPVLLLGET 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 695764630   87 GDVPMAVEAVKKgawdfLQKPVNPGQLLDLI 117
Cdd:pfam06490  78 DDALELANVIGT-----LEEPLNYPQLTDLL 103
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 8-122 8.29e-05

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 41.95  E-value: 8.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGH-RVYA-CGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILIT- 84
Cdd:cd19931    1 VLLIDDHPLLRKGIKQLIELDPDfTVVGeASSGEEGIELAERLDPDLILLDLNMKGMSGLDTLKALREEGVSARIVILTv 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 695764630  85 --GHGDVpmaVEAVKKGAWDFLQKPVNPGQLLDLIDKALA 122
Cdd:cd19931   81 sdAEDDV---VTALRAGADGYLLKDMEPEDLLEALKQAAS 117
REC_typeA_ARR cd17581
phosphoacceptor receiver (REC) domain of type A Arabidopsis response regulators (ARRs) and ...
 52-110 1.15e-04

phosphoacceptor receiver (REC) domain of type A Arabidopsis response regulators (ARRs) and similar proteins; Type-A response regulators of Arabidopsis (ARRs) are involved in cytokinin signaling, which involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Type-A ARRs function downstream of and are regulated by type-B ARRs, which are a class of MYB-type transcription factors. As primary cytokinin response genes, type-A ARRs act as redundant negative feedback regulators of cytokinin signaling by inactivating the phosphorelay. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-A ARRs are similar in domain structure to CheY, in that they lack a typical output domain and only contain a stand-alone receiver (REC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381119 [Multi-domain]  Cd Length: 122  Bit Score: 41.58  E-value: 1.15e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 695764630  52 IVLSDVCMPHCSGIDLLKILLKHDP--HLPVILITGHGDVPMAVEAVKKGAWDFLQKPVNP 110
Cdd:cd17581   56 MIITDYCMPGMTGYDLLKKVKESSAlkEIPVVIMSSENIPTRISRCLEEGAEDFLLKPVKL 116
PRK10336 PRK10336
two-component system response regulator QseB;
8-131 1.34e-04

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 42.96  E-value: 1.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQD-LVSEAWPGIVLsDVCMPHCSGIDLLKILLKHDPHLPVILITGH 86
Cdd:PRK10336   3 ILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEaLYSAPYDAVIL-DLTLPGMDGRDILREWREKGQREPVLILTAR 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 695764630  87 GDVPMAVEAVKKGAWDFLQKPvnpgqlLDLIDkaLAQRQSQVVRR 131
Cdd:PRK10336  82 DALAERVEGLRLGADDYLCKP------FALIE--VAARLEALMRR 118
PLN03029 PLN03029
type-a response regulator protein; Provisional
 52-158 1.65e-04

type-a response regulator protein; Provisional


Pssm-ID: 215544 [Multi-domain]  Cd Length: 222  Bit Score: 42.71  E-value: 1.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630  52 IVLSDVCMPHCSGIDLLKILLKHDP--HLPVILITGHgDVPMAV-EAVKKGAWDFLQKPVnpgQLLDL------IDKALA 122
Cdd:PLN03029  75 LIITDYCMPGMTGYDLLKKIKESSSlrNIPVVIMSSE-NVPSRItRCLEEGAEEFFLKPV---QLSDLnrlkphMMKTKS 150

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 695764630 123 QRQSQvvRRQWQKEQLEDNLIGRSEWVTQMRQTLQQ 158
Cdd:PLN03029 151 KNQKQ--ENQEKQEKLEESEIQSEKQEQPSQQPQSQ 184
PRK10816 PRK10816
two-component system response regulator PhoP;
8-107 1.81e-04

two-component system response regulator PhoP;


Pssm-ID: 182755 [Multi-domain]  Cd Length: 223  Bit Score: 42.42  E-value: 1.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITGHG 87
Cdd:PRK10816   3 VLVVEDNALLRHHLKVQLQDAGHQVDAAEDAKEADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSNDVSLPILVLTARE 82

                         90       100
                 ....*....|....*....|
gi 695764630  88 DVPMAVEAVKKGAWDFLQKP 107
Cdd:PRK10816  83 SWQDKVEVLSAGADDYVTKP 102
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 7-121 2.04e-04

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 42.48  E-value: 2.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   7 NILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPhLPVILITGH 86
Cdd:PRK10529   3 NVLIVEDEQAIRRFLRTALEGDGMRVFEAETLQRGLLEAATRKPDLIILDLGLPDGDGIEFIRDLRQWSA-IPVIVLSAR 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 695764630  87 GDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKAL 121
Cdd:PRK10529  82 SEESDKIAALDAGADDYLSKPFGIGELQARLRVAL 116
PRK11697 PRK11697
two-component system response regulator BtsR;
7-113 2.23e-04

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 42.53  E-value: 2.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   7 NILLIDDDSDVLDAYTQLLTQAGH-RVYA-CGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILlkhDP-HLP-VIL 82
Cdd:PRK11697   3 KVLIVDDEPLAREELRELLQEEGDiEIVGeCSNAIEAIGAIHRLKPDVVFLDIQMPRISGLELVGML---DPeHMPyIVF 79

                         90       100       110
                 ....*....|....*....|....*....|.
gi 695764630  83 ITGHGDvpMAVEAVKKGAWDFLQKPVNPGQL 113
Cdd:PRK11697  80 VTAFDE--YAIKAFEEHAFDYLLKPIDPARL 108
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
 8-121 2.43e-04

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 40.61  E-value: 2.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVldaytQLLTQ------AGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKiLLKHDP---HL 78
Cdd:cd17552    4 ILVIDDEEDI-----REVVQacleklAGWEVLTASSGQEGLEKAATEQPDAILLDVMMPDMDGLATLK-KLQANPetqSI 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 695764630  79 PVILITGHGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKAL 121
Cdd:cd17552   78 PVILLTAKAQPSDRQRFASLGVAGVIAKPFDPLTLAEQIAKLL 120
PRK13856 PRK13856
two-component response regulator VirG; Provisional
 7-130 3.45e-04

two-component response regulator VirG; Provisional


Pssm-ID: 172377 [Multi-domain]  Cd Length: 241  Bit Score: 41.72  E-value: 3.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   7 NILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKIL-LKHDphLPVILITG 85
Cdd:PRK13856   3 HVLVIDDDVAMRHLIVEYLTIHAFKVTAVADSQQFNRVLASETVDVVVVDLNLGREDGLEIVRSLaTKSD--VPIIIISG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 695764630  86 HG-DVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDKALAQRqSQVVR 130
Cdd:PRK13856  81 DRlEEADKVVALELGATDFIAKPFGTREFLARIRVALRVR-PNVVR 125
PRK10840 PRK10840
transcriptional regulator RcsB; Provisional
 52-130 3.96e-04

transcriptional regulator RcsB; Provisional


Pssm-ID: 182771 [Multi-domain]  Cd Length: 216  Bit Score: 41.36  E-value: 3.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630  52 IVLSDVCMP---HCSGIDLLKILLKHDPHLPVILITGHG------------------------DVPMAVEAVKKGAwDFL 104
Cdd:PRK10840  52 VLITDLSMPgdkYGDGITLIKYIKRHFPSLSIIVLTMNNnpailsavldldiegivlkqgaptDLPKALAALQKGK-KFT 130

                         90       100       110
                 ....*....|....*....|....*....|..
gi 695764630 105 qkPVNPGQLLDLI------DKALAQRQSQVVR 130
Cdd:PRK10840 131 --PESVSRLLEKIsaggygDKRLSPKESEVLR 160
REC_GlnL-like cd17565
phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar ...
 8-108 5.73e-04

phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar proteins; Bacillus subtilis GlnL is part of the GlnK-GlnL (formerly YcbA-YcbB) two-component system that positively regulates the expression of the glsA-glnT (formerly ybgJ-ybgH) operon in response to glutamine. It contains a REC domain and a DNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381112 [Multi-domain]  Cd Length: 103  Bit Score: 39.18  E-value: 5.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQA--GHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITG 85
Cdd:cd17565    1 FYIVDDDKNIIKILSDIIEDDdlGEVVGEADNGAQAYDEILFLQPDIVLIDLLMPGMDGIQLVRKLKDTGSNGKFIMISQ 80

                         90       100
                 ....*....|....*....|...
gi 695764630  86 HGDVPMAVEAVKKGAWDFLQKPV 108
Cdd:cd17565   81 VSDKEMIGKAYQAGIEFFINKPI 103
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
 8-107 6.02e-04

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 39.28  E-value: 6.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRA----------QDLVSEAWPgIVLSDVCMPHCSGIDLLKiLLKHDP- 76
Cdd:cd19924    1 ILVVDDSPTARKQLRDLLKNLGFEIAEAVDGEEAlnklenlakeGNDLSKELD-LIITDIEMPKMDGYELTF-ELRDDPr 78

                         90       100       110
                 ....*....|....*....|....*....|...
gi 695764630  77 --HLPVILITGHGDVPMAVEAVKKGAWDFLQKP 107
Cdd:cd19924   79 laNIPVILNSSLSGEFSRARGKKVGADAYLAKF 111
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 6-114 7.44e-04

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 38.90  E-value: 7.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   6 HNILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLVSEAWPGIVLSDVCMPhcsGIDLLKIL--LKHDPHLPVILI 83
Cdd:cd17622    1 TRILLVEDDPKLARLIADFLESHGFNVVVEHRGDRALEVIAREKPDAVLLDIMLP---GIDGLTLCrdLRPKYQGPILLL 77

                         90       100       110
                 ....*....|....*....|....*....|.
gi 695764630  84 TGHGDVPMAVEAVKKGAWDFLQKPVNPGQLL 114
Cdd:cd17622   78 TALDSDIDHILGLELGADDYVVKPVEPAVLL 108
PRK10693 PRK10693
two-component system response regulator RssB;
33-108 8.06e-04

two-component system response regulator RssB;


Pssm-ID: 182652 [Multi-domain]  Cd Length: 303  Bit Score: 41.13  E-value: 8.06e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 695764630  33 YACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITGHGDVPMAVEAVKKGAWDFLQKPV 108
Cdd:PRK10693   1 VLAANGVDALELLGGFTPDLIICDLAMPRMNGIEFVEHLRNRGDQTPVLVISATENMADIAKALRLGVQDVLLKPV 76
PRK10610 PRK10610
chemotaxis protein CheY;
9-119 8.39e-04

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 39.19  E-value: 8.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   9 LLIDDDSDVLDAYTQLLTQAG-HRVYACGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKIlLKHD---PHLPVILIT 84
Cdd:PRK10610   9 LVVDDFSTMRRIVRNLLKELGfNNVEEAEDGVDALNKLQAGGFGFVISDWNMPNMDGLELLKT-IRADgamSALPVLMVT 87

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 695764630  85 GHGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLIDK 119
Cdd:PRK10610  88 AEAKKENIIAAAQAGASGYVVKPFTAATLEEKLNK 122
PRK09483 PRK09483
response regulator; Provisional
 50-117 9.66e-04

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 40.47  E-value: 9.66e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 695764630  50 PGIVLSDVCMPHCSGIDLLKILLKHDPHLPVILITGHGDVPMAVEAVKKGAWDFLQKPVNPGQLLDLI 117
Cdd:PRK09483  48 VDVVLMDMNMPGIGGLEATRKILRYTPDVKIIMLTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAI 115
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
 7-107 3.49e-03

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 36.82  E-value: 3.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   7 NILLIDDDSD---VLDAYtqLLTQAGHRVYA-CGDPLRAQDLVSEAWPGIVLSDVCMPHCSGIDLLKIL----LKHDPHl 78
Cdd:cd17561    3 KVLIADDNREfvqLLEEY--LNSQPDMEVVGvAHNGQEALELIEEKEPDVLLLDIIMPHLDGIGVLEKLrrmrLEKRPK- 79

                         90       100
                 ....*....|....*....|....*....
gi 695764630  79 pVILITGHGDVPMAVEAVKKGAWDFLQKP 107
Cdd:cd17561   80 -IIMLTAFGQEDITQRAVELGASYYILKP 107
REC_TrxB cd17595
phosphoacceptor receiver (REC) domain a fused response regulator with a thioredoxin reductase ...
 8-118 3.85e-03

phosphoacceptor receiver (REC) domain a fused response regulator with a thioredoxin reductase output domain; This family is composed of uncharacterized fusion proteins containing a REC domain and a thioredoxin reductase domain. Thioredoxin reductase catalyzes the reduction of thioredoxin and is thus a central component in the thioredoxin system. Fusion proteins containing REC and thioredoxin reductase domains could play an important role in the environmental regulation of the cellular dithiol-disulfide ratio. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381126 [Multi-domain]  Cd Length: 135  Bit Score: 37.32  E-value: 3.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLT---QAGHRVYACGDPLRAQDLVSEAWP-----GIVLSDVCMPHCSGIDLLKILLKHDPHLP 79
Cdd:cd17595    3 ILTVDDDPQVLRAVARDLRrqyGKDYRVLRADSGAEALDALKELKLrgeavALFLVDQRMPEMDGVEFLEKAMELFPEAK 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 695764630  80 VILITGHGDVPMAVEAVKKGAWDF-LQKPVNPGQ------LLDLID 118
Cdd:cd17595   83 RVLLTAYADTDAAIRAINDVQLDYyLLKPWDPPEeklypvLDDLLD 128
psREC-like_D2_PleD cd17539
REC-like adaptor domain (D2) of response regulator PleD; PleD contains a REC domain (D1) with ...
 8-134 4.63e-03

REC-like adaptor domain (D2) of response regulator PleD; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a pseudo receiver (psREC)-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes the REC-like adaptor domain D2 of PleD, which is an inactive domain.


Pssm-ID: 381094 [Multi-domain]  Cd Length: 124  Bit Score: 36.91  E-value: 4.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTqAGHRVYACGDPlraQDLVSEAWPG-----IVLSDVcmphcSGIDLLKIL-----LKHDPH 77
Cdd:cd17539    1 VLLVDDRPSSAERIAAMLS-SEHEVVVEADP---DEALFRAAEGpfdlvIVSLAL-----EDFDGLRLCsqlrsLERTRQ 71

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 695764630  78 LPVILITGHGDVPMAVEAVKKGAWDFLQKPVNPGQLldlidkaLAQRQSQVVRRQWQ 134
Cdd:cd17539   72 LPILAVADPGDRGRLIRALEIGVNDYLVRPIDPNEL-------LARVRTQIRRKRYT 121
PRK13557 PRK13557
histidine kinase; Provisional
 8-114 5.35e-03

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 38.88  E-value: 5.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630   8 ILLIDDDSDVLDAYTQLLTQAGHRVYACGDPLRAQDLV-SEAWPGIVLSDVCMP-HCSGIDLLKILLKHDPHLPVILITG 85
Cdd:PRK13557 418 ILIVDDRPDVAELARMILEDFGYRTLVASNGREALEILdSHPEVDLLFTDLIMPgGMNGVMLAREARRRQPKIKVLLTTG 497

                         90       100
                 ....*....|....*....|....*....
gi 695764630  86 HGDVPMAVEAVKKGAWDFLQKPVNPGQLL 114
Cdd:PRK13557 498 YAEASIERTDAGGSEFDILNKPYRRAELA 526
REC_LytTR_AgrA-like cd17533
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; ...
 63-121 5.47e-03

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AgrA-like group of LytTR/AlgR family response regulators are Staphylococcus aureus accessory gene regulator protein A (AgrA) and Streptococcus pneumoniae response regulator ComE, which are members of two-component regulatory systems. AgrA is a global regulator that controls the synthesis of virulence factors and other exoproteins. ComE is part of the ComD-ComE system that is part of a quorum-sensing signaling pathway that controls the development of competence, a physiological state required for genetic transformation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381088 [Multi-domain]  Cd Length: 131  Bit Score: 36.83  E-value: 5.47e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764630  63 SGIDLLKILLKHDPHLPVILITGHGD-VPMAVEaVKKGAWDFLQKPVNPGQLLDLIDKAL 121
Cdd:cd17533   67 NGLEVAQKIRKYDPYAIIIFVTTHSEfAPLTFE-YKVAALDFILKPLKLEEFKKRIEECI 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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