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Conserved domains on  [gi|696297105|ref|WP_032872661|]
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MULTISPECIES: AraC family transcriptional regulator [Acinetobacter]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 12071874)

AraC family transcriptional regulator containing an AraC family helix-turn-helix (HTH) DNA-binding domain, may regulate the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|15808743|9409145|33837749|11282467

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AraC_N pfam06719
AraC-type transcriptional regulator N-terminus; This family represents the N-terminus of ...
 24-169 2.49e-40

AraC-type transcriptional regulator N-terminus; This family represents the N-terminus of bacterial ARAC-type transcriptional regulators. In E. coli, these regulate the L-arabinose operon through sensing the presence of arabinose, and when the sugar is present, transmitting this information from the arabinose-binding domains to the protein's DNA-binding domains. This family might represent the N-terminal arm of the protein, which binds to the C-terminal DNA binding domains to hold them in a state where the protein prefers to loop and remain non-activating. All family members contain the pfam00165 domain.


:

Pssm-ID: 461994  Cd Length: 152  Bit Score: 137.25  E-value: 2.49e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105   24 AIDGIVLMRVDHNTPPIAVLQEPTLVFVLQGQKRGYIGTETYSFQQGQCLIVSVSMPFDCDTI-ASAEAPMIAISMKLDA 102
Cdd:pfam06719   1 AIPGLTLFRTSEPTEPTPVVYEPSLCIVAQGAKRVHLGDETYEYDPGEYLVVSVDLPVTGEVTeASPEEPYLGLALDLDP 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 696297105  103 DTVNELLAKTYFENYQFKPlTTGMSVIEYDQAISSVLNRLLQTLTSEQDVLVLGEQIKRELLYRVIQ 169
Cdd:pfam06719  81 ALLAELLLEAPPPGPPPRA-GRGLAVSPLDEELLDAVLRLLRLLDTPEDIPVLAPLILREILYRLLT 146
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
202-283 2.13e-30

helix_turn_helix, arabinose operon control protein;


:

Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 109.56  E-value: 2.13e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105   202 KLTVDMLAEQANMSTSAFHKAFKQVTQHSPLQYLKVVRLHKAKQLLQNADQSVAQAAYAVGYQSSSQFSREFKKQFGFPP 281
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ..
gi 696297105   282 KH 283
Cdd:smart00342  81 SE 82
 
Name Accession Description Interval E-value
AraC_N pfam06719
AraC-type transcriptional regulator N-terminus; This family represents the N-terminus of ...
 24-169 2.49e-40

AraC-type transcriptional regulator N-terminus; This family represents the N-terminus of bacterial ARAC-type transcriptional regulators. In E. coli, these regulate the L-arabinose operon through sensing the presence of arabinose, and when the sugar is present, transmitting this information from the arabinose-binding domains to the protein's DNA-binding domains. This family might represent the N-terminal arm of the protein, which binds to the C-terminal DNA binding domains to hold them in a state where the protein prefers to loop and remain non-activating. All family members contain the pfam00165 domain.


Pssm-ID: 461994  Cd Length: 152  Bit Score: 137.25  E-value: 2.49e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105   24 AIDGIVLMRVDHNTPPIAVLQEPTLVFVLQGQKRGYIGTETYSFQQGQCLIVSVSMPFDCDTI-ASAEAPMIAISMKLDA 102
Cdd:pfam06719   1 AIPGLTLFRTSEPTEPTPVVYEPSLCIVAQGAKRVHLGDETYEYDPGEYLVVSVDLPVTGEVTeASPEEPYLGLALDLDP 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 696297105  103 DTVNELLAKTYFENYQFKPlTTGMSVIEYDQAISSVLNRLLQTLTSEQDVLVLGEQIKRELLYRVIQ 169
Cdd:pfam06719  81 ALLAELLLEAPPPGPPPRA-GRGLAVSPLDEELLDAVLRLLRLLDTPEDIPVLAPLILREILYRLLT 146
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
202-283 2.13e-30

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 109.56  E-value: 2.13e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105   202 KLTVDMLAEQANMSTSAFHKAFKQVTQHSPLQYLKVVRLHKAKQLLQNADQSVAQAAYAVGYQSSSQFSREFKKQFGFPP 281
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ..
gi 696297105   282 KH 283
Cdd:smart00342  81 SE 82
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
121-283 2.70e-28

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 109.48  E-value: 2.70e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105 121 PLTTGMSVIEYDQAISSVLNRLLQTLTSEQDVLVLGEQIKRELLYRVIQHAGADALKGLVAQGNLRPIYKICEYIQHHFT 200
Cdd:COG2207   87 ALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105 201 EKLTVDMLAEQANMSTSAFHKAFKQVTQHSPLQYLKVVRLHKAKQLLQNADQSVAQAAYAVGYQSSSQFSREFKKQFGFP 280
Cdd:COG2207  167 LLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVT 246


                 ...
gi 696297105 281 PKH 283
Cdd:COG2207  247 PSE 249
HTH_18 pfam12833
Helix-turn-helix domain;
208-283 4.78e-24

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 92.65  E-value: 4.78e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 696297105  208 LAEQANMSTSAFHKAFKQVTQHSPLQYLKVVRLHKAKQLL-QNADQSVAQAAYAVGYQSSSQFSREFKKQFGFPPKH 283
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLlEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSE 77
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
181-282 3.91e-16

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 76.64  E-value: 3.91e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105 181 AQGNLRPIYKICEYIQHHFTEKLTVDMLAEQANMSTSAFHKAFKQVTQHSPLQYLKVVRLHKAKQLLQNADQSVAQAAYA 260
Cdd:PRK13503 166 GENSDARLNQLLAWLEDHFAEEVNWEALADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKARHLLRHSDASVTDIAYR 245

                         90       100
                 ....*....|....*....|..
gi 696297105 261 VGYQSSSQFSREFKKQFGFPPK 282
Cdd:PRK13503 246 CGFGDSNHFSTLFRREFSWSPR 267
adjacent_YSIRK TIGR04094
YSIRK-targeted surface antigen transcriptional regulator; Bacteria whose genomes encode only ...
 188-282 1.23e-09

YSIRK-targeted surface antigen transcriptional regulator; Bacteria whose genomes encode only one protein with the YSIRK variant form of signal peptide (TIGR01168) were examined for conserved genes near that one tagged protein. This protein is found adjacent to at various classes of repetitive or low-complexity YSIRK proteins (whether unique in genome or not), in a range of species (Enterococcus faecalis X98, Ruminococcus torques, Coprobacillus sp. D7, Lysinibacillus fusiformis ZC1, Streptococcus equi subsp. equi 4047, etc). The affliated YSIRK proteins include Streptococcal protective antigen (see ) and proteins with the Rib/alpha/Esp surface antigen repeat (see TIGR02331). The last quarter of this protein has an AraC family helix-turn-helix (HTH)transcriptional regulator domain.


Pssm-ID: 274977 [Multi-domain]  Cd Length: 383  Bit Score: 58.53  E-value: 1.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105  188 IYKICEYIQHHFTEKLTVDMLAEQANMSTSAFHKAFKQVTQHSPLQYLKVVRLHKAKQLLQNAdQSVAQAAYAVGYQSSS 267
Cdd:TIGR04094 287 IRAVIQYINLNLYDPLKVEEIAKQFFMSESKLRKLFKKEMGISIQEYISKRKIEEAKYLLRSQ-IPVSEVSNELGFYDLS 365

                          90
                  ....*....|....*
gi 696297105  268 QFSREFKKQFGFPPK 282
Cdd:TIGR04094 366 HFSRTFKKHTGVSPK 380
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 98-281 1.17e-06

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 48.91  E-value: 1.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105  98 MKLDADTVNELLAKTYFENYQFK-PLT---TGMSVIEYDQAISSVLNRLLQTLTSEQDVLVLGEQIKRELLYRVIQHAGA 173
Cdd:PRK15186  91 IELDSASIKNAYNFFLYEHADFSaPLTkptTKHLLAPIETGVARVFNLLHSSNKSQKLSQDKKEYLIRFLLSEFIYEPEA 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105 174 DALKGLVAQGNL-RPIYKIceyIQHHFTEKLTVDMLAEQANMSTSAFHKAFKQVTQHSPLQYLKVvRLHKAKQLLQNADQ 252
Cdd:PRK15186 171 FALFRELSQNTLaENIYNI---IISDISRKWALKDISDSLYMSCSTLKRKLKQENTSFSEVYLNA-RMNKATKLLRNSEY 246

                        170       180
                 ....*....|....*....|....*....
gi 696297105 253 SVAQAAYAVGYQSSSQFSREFKKQFGFPP 281
Cdd:PRK15186 247 NITRVAYMCGYDSASYFTCVFKKHFKTTP 275
 
Name Accession Description Interval E-value
AraC_N pfam06719
AraC-type transcriptional regulator N-terminus; This family represents the N-terminus of ...
 24-169 2.49e-40

AraC-type transcriptional regulator N-terminus; This family represents the N-terminus of bacterial ARAC-type transcriptional regulators. In E. coli, these regulate the L-arabinose operon through sensing the presence of arabinose, and when the sugar is present, transmitting this information from the arabinose-binding domains to the protein's DNA-binding domains. This family might represent the N-terminal arm of the protein, which binds to the C-terminal DNA binding domains to hold them in a state where the protein prefers to loop and remain non-activating. All family members contain the pfam00165 domain.


Pssm-ID: 461994  Cd Length: 152  Bit Score: 137.25  E-value: 2.49e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105   24 AIDGIVLMRVDHNTPPIAVLQEPTLVFVLQGQKRGYIGTETYSFQQGQCLIVSVSMPFDCDTI-ASAEAPMIAISMKLDA 102
Cdd:pfam06719   1 AIPGLTLFRTSEPTEPTPVVYEPSLCIVAQGAKRVHLGDETYEYDPGEYLVVSVDLPVTGEVTeASPEEPYLGLALDLDP 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 696297105  103 DTVNELLAKTYFENYQFKPlTTGMSVIEYDQAISSVLNRLLQTLTSEQDVLVLGEQIKRELLYRVIQ 169
Cdd:pfam06719  81 ALLAELLLEAPPPGPPPRA-GRGLAVSPLDEELLDAVLRLLRLLDTPEDIPVLAPLILREILYRLLT 146
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
202-283 2.13e-30

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 109.56  E-value: 2.13e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105   202 KLTVDMLAEQANMSTSAFHKAFKQVTQHSPLQYLKVVRLHKAKQLLQNADQSVAQAAYAVGYQSSSQFSREFKKQFGFPP 281
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ..
gi 696297105   282 KH 283
Cdd:smart00342  81 SE 82
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
121-283 2.70e-28

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 109.48  E-value: 2.70e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105 121 PLTTGMSVIEYDQAISSVLNRLLQTLTSEQDVLVLGEQIKRELLYRVIQHAGADALKGLVAQGNLRPIYKICEYIQHHFT 200
Cdd:COG2207   87 ALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105 201 EKLTVDMLAEQANMSTSAFHKAFKQVTQHSPLQYLKVVRLHKAKQLLQNADQSVAQAAYAVGYQSSSQFSREFKKQFGFP 280
Cdd:COG2207  167 LLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVT 246


                 ...
gi 696297105 281 PKH 283
Cdd:COG2207  247 PSE 249
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 190-281 5.26e-27

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 107.17  E-value: 5.26e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105 190 KICEYIQHHFTEKLTVDMLAEQANMSTSAFHKAFKQVTQHSPLQYLKVVRLHKAKQLLQNADQSVAQAAYAVGYQSSSQF 269
Cdd:COG4977  214 RAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFGSASHF 293

                         90
                 ....*....|..
gi 696297105 270 SREFKKQFGFPP 281
Cdd:COG4977  294 RRAFRRRFGVSP 305
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 190-282 1.53e-26

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 106.68  E-value: 1.53e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105 190 KICEYIQHHFTEKLTVDMLAEQANMSTSAFHKAFKQVTQHSPLQYLKVVRLHKAKQLLQnADQSVAQAAYAVGYQSSSQF 269
Cdd:COG2169   88 RACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQ-TGLSVTDAAYAAGFGSLSRF 166

                         90
                 ....*....|...
gi 696297105 270 SREFKKQFGFPPK 282
Cdd:COG2169  167 YEAFKKLLGMTPS 179
HTH_18 pfam12833
Helix-turn-helix domain;
208-283 4.78e-24

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 92.65  E-value: 4.78e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 696297105  208 LAEQANMSTSAFHKAFKQVTQHSPLQYLKVVRLHKAKQLL-QNADQSVAQAAYAVGYQSSSQFSREFKKQFGFPPKH 283
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLlEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSE 77
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
181-282 3.91e-16

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 76.64  E-value: 3.91e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105 181 AQGNLRPIYKICEYIQHHFTEKLTVDMLAEQANMSTSAFHKAFKQVTQHSPLQYLKVVRLHKAKQLLQNADQSVAQAAYA 260
Cdd:PRK13503 166 GENSDARLNQLLAWLEDHFAEEVNWEALADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKARHLLRHSDASVTDIAYR 245

                         90       100
                 ....*....|....*....|..
gi 696297105 261 VGYQSSSQFSREFKKQFGFPPK 282
Cdd:PRK13503 246 CGFGDSNHFSTLFRREFSWSPR 267
ftrA PRK09393
transcriptional activator FtrA; Provisional
 180-281 2.03e-15

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 75.00  E-value: 2.03e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105 180 VAQGNLRPIYKICEYIQHHFTEKLTVDMLAEQANMSTSAFHKAFKQVTQHSPLQYLKVVRLHKAKQLLQNADQSVAQAAY 259
Cdd:PRK09393 212 VASRESDRLGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLESSALSIDQIAE 291

                         90       100
                 ....*....|....*....|..
gi 696297105 260 AVGYQSSSQFSREFKKQFGFPP 281
Cdd:PRK09393 292 RAGFGSEESLRHHFRRRAATSP 313
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
188-282 1.29e-11

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 63.84  E-value: 1.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105 188 IYKICEYIQHHFTEKLTVDMLAEQANMSTSAFHKAFKQVTQHSPLQYLKVVRLHKAKQLLQNADQSVAQAAYAVGYQSSS 267
Cdd:PRK10572 185 VREACQYISDHLASEFDIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKLLLQTTRMPIATIGRNVGYDDQL 264

                         90
                 ....*....|....*
gi 696297105 268 QFSREFKKQFGFPPK 282
Cdd:PRK10572 265 YFSRVFKKCTGASPS 279
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 180-282 1.61e-10

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 60.43  E-value: 1.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105 180 VAQGNLRPIYKICEYIQHHFT-EKLTVDMLAEQANMSTSAFHKAFKQvTQHSPLQYLKVVRLHKAKQLLQNA--DQSVAQ 256
Cdd:PRK09685 191 VQPRRERQFQKVVALIDQSIQeEILRPEWIAGELGISVRSLYRLFAE-QGLVVAQYIRNRRLDRCADDLRPAadDEKITS 269

                         90       100
                 ....*....|....*....|....*.
gi 696297105 257 AAYAVGYQSSSQFSREFKKQFGFPPK 282
Cdd:PRK09685 270 IAYKWGFSDSSHFSTAFKQRFGVSPG 295
PRK10371 PRK10371
transcriptional regulator MelR;
193-281 9.46e-10

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 58.29  E-value: 9.46e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105 193 EYIQHHFTEKLTVDMLAEQANMSTSAFHKAFKQVTQHSPLQYLKVVRLHKAKQLLQNADQSVAQAAYAVGYQSSSQFSRE 272
Cdd:PRK10371 198 GFIAENYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDTDKSILDIALTAGFRSSSRFYST 277


                 ....*....
gi 696297105 273 FKKQFGFPP 281
Cdd:PRK10371 278 FGKYVGMSP 286
adjacent_YSIRK TIGR04094
YSIRK-targeted surface antigen transcriptional regulator; Bacteria whose genomes encode only ...
 188-282 1.23e-09

YSIRK-targeted surface antigen transcriptional regulator; Bacteria whose genomes encode only one protein with the YSIRK variant form of signal peptide (TIGR01168) were examined for conserved genes near that one tagged protein. This protein is found adjacent to at various classes of repetitive or low-complexity YSIRK proteins (whether unique in genome or not), in a range of species (Enterococcus faecalis X98, Ruminococcus torques, Coprobacillus sp. D7, Lysinibacillus fusiformis ZC1, Streptococcus equi subsp. equi 4047, etc). The affliated YSIRK proteins include Streptococcal protective antigen (see ) and proteins with the Rib/alpha/Esp surface antigen repeat (see TIGR02331). The last quarter of this protein has an AraC family helix-turn-helix (HTH)transcriptional regulator domain.


Pssm-ID: 274977 [Multi-domain]  Cd Length: 383  Bit Score: 58.53  E-value: 1.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105  188 IYKICEYIQHHFTEKLTVDMLAEQANMSTSAFHKAFKQVTQHSPLQYLKVVRLHKAKQLLQNAdQSVAQAAYAVGYQSSS 267
Cdd:TIGR04094 287 IRAVIQYINLNLYDPLKVEEIAKQFFMSESKLRKLFKKEMGISIQEYISKRKIEEAKYLLRSQ-IPVSEVSNELGFYDLS 365

                          90
                  ....*....|....*
gi 696297105  268 QFSREFKKQFGFPPK 282
Cdd:TIGR04094 366 HFSRTFKKHTGVSPK 380
PRK11511 PRK11511
MDR efflux pump AcrAB transcriptional activator MarA;
188-292 3.10e-09

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 236920 [Multi-domain]  Cd Length: 127  Bit Score: 54.34  E-value: 3.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105 188 IYKICEYIQHHFTEKLTVDMLAEQANMSTSAFHKAFKQVTQHSPLQYLKVVRLHKAKQLLQNADQSVAQAAYAVGYQSSS 267
Cdd:PRK11511  11 IHSILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERYGFESQQ 90

                         90       100
                 ....*....|....*....|....*.
gi 696297105 268 QFSREFKKQFGFPP-KHAESNTETES 292
Cdd:PRK11511  91 TLTRTFKNYFDVPPhKYRMTNMQGES 116
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 195-236 2.05e-08

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 49.46  E-value: 2.05e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 696297105  195 IQHHFTEKLTVDMLAEQANMSTSAFHKAFKQVTQHSPLQYLK 236
Cdd:pfam00165   1 LRENLSTNLTIADIADELGFSRSYFSRLFKKYTGVTPSQYRH 42
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
188-281 3.76e-08

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 50.69  E-value: 3.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105 188 IYKICEYIQHHFTEKLTVDMLAEQANMSTSAFHKAFKQVTQHSPLQYLKVVRLHKAKQLLQNADQSVAQAAYAVGYQSSS 267
Cdd:PRK10219   7 IQTLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQ 86

                         90
                 ....*....|....
gi 696297105 268 QFSREFKKQFGFPP 281
Cdd:PRK10219  87 TFSRVFRRQFDRTP 100
PRK15435 PRK15435
bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;
169-282 9.89e-08

bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;


Pssm-ID: 185333 [Multi-domain]  Cd Length: 353  Bit Score: 52.49  E-value: 9.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105 169 QHAGADAlkglvAQGNLRPIYKICEYIQHHftEKLTVDMLAEQANMSTSAFHKAFKQVTQHSPLQYLKVVRLHKAKQLLQ 248
Cdd:PRK15435  73 QPDKANP-----QQHRLDKITHACRLLEQE--TPVTLEALADQVAMSPFHLHRLFKATTGMTPKAWQQAWRARRLREALA 145

                         90       100       110
                 ....*....|....*....|....*....|....
gi 696297105 249 NADqSVAQAAYAVGYQSSSQFSREFKKQFGFPPK 282
Cdd:PRK15435 146 KGE-SVTTSILNAGFPDSSSYYRKADETLGMTAK 178
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 98-281 1.17e-06

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 48.91  E-value: 1.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105  98 MKLDADTVNELLAKTYFENYQFK-PLT---TGMSVIEYDQAISSVLNRLLQTLTSEQDVLVLGEQIKRELLYRVIQHAGA 173
Cdd:PRK15186  91 IELDSASIKNAYNFFLYEHADFSaPLTkptTKHLLAPIETGVARVFNLLHSSNKSQKLSQDKKEYLIRFLLSEFIYEPEA 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105 174 DALKGLVAQGNL-RPIYKIceyIQHHFTEKLTVDMLAEQANMSTSAFHKAFKQVTQHSPLQYLKVvRLHKAKQLLQNADQ 252
Cdd:PRK15186 171 FALFRELSQNTLaENIYNI---IISDISRKWALKDISDSLYMSCSTLKRKLKQENTSFSEVYLNA-RMNKATKLLRNSEY 246

                        170       180
                 ....*....|....*....|....*....
gi 696297105 253 SVAQAAYAVGYQSSSQFSREFKKQFGFPP 281
Cdd:PRK15186 247 NITRVAYMCGYDSASYFTCVFKKHFKTTP 275
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
210-282 1.35e-05

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 45.67  E-value: 1.35e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 696297105 210 EQANMSTSAFHKAFKQVTQHSPLQYLKVVRLHKAKQLLQNADQSVAQAAYAVGYQSSSQFSREFKKQFGFPPK 282
Cdd:PRK13501 200 HKNQLVERSLKQLFRQQTGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDSNYFSAVFTREAGMTPR 272
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 180-281 2.36e-05

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 44.92  E-value: 2.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105 180 VAQGNLRPiyKICEYIQHHFTEKLTVDMLAEQANMSTSAFHKAFkQVTQHSPLQYLKVVRLHKAKQLLQNADQSVAQAAY 259
Cdd:PRK09978 138 VLQPNMRT--RVCTVINNNIAHEWTLARIASELLMSPSLLKKKL-REEETSYSQLLTECRMQRALQLIVIHGFSIKRVAV 214

                         90       100
                 ....*....|....*....|..
gi 696297105 260 AVGYQSSSQFSREFKKQFGFPP 281
Cdd:PRK09978 215 SCGYHSVSYFIYVFRNYYGMTP 236
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
203-281 9.12e-05

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 43.12  E-value: 9.12e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 696297105 203 LTVDMLAEQANMSTSAFHKAFKQVTQHSPLQYLKVVRLHKAKQLLQNADQSVAQAAYAVGYQSSSQFSREFKKQFGFPP 281
Cdd:PRK13502 193 FALDAFCQQEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSVVFTRETGMTP 271
PRK10296 PRK10296
DNA-binding transcriptional regulator ChbR; Provisional
 199-283 1.23e-04

DNA-binding transcriptional regulator ChbR; Provisional


Pssm-ID: 182362 [Multi-domain]  Cd Length: 278  Bit Score: 42.82  E-value: 1.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105 199 FTEKLTVDMLAEQANmSTSAFHKAFKQVTQHSPLQYLKVVRLHKAKQLLQNADQSVAQAAYAVGYQSSSQFSREFKKQFG 278
Cdd:PRK10296 186 FSESALENMVRLSGK-SQEYLTRATRRYYGKTPMQIINEIRINFAKKQLEMTNYSVTDIAFEAGYSSPSLFIKTFKKLTS 264


                 ....*
gi 696297105 279 FPPKH 283
Cdd:PRK10296 265 FTPGS 269
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
203-283 2.09e-04

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 42.01  E-value: 2.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105 203 LTVDMLAEQANMSTSAFHKAFKQVTQHSPLQYLKVVRLHKAKQLLQNADQSVAQAAYAVGYQSSSQFSREFKKQFGFPPK 282
Cdd:PRK13500 223 FALDKFCDEASCSERVLRQQFRQQTGMTINQYLRQVRVCHAQYLLQHSRLLISDISTECGFEDSNYFSVVFTRETGMTPS 302


                 .
gi 696297105 283 H 283
Cdd:PRK13500 303 Q 303
PRK15121 PRK15121
MDR efflux pump AcrAB transcriptional activator RobA;
198-281 1.38e-03

MDR efflux pump AcrAB transcriptional activator RobA;


Pssm-ID: 185076 [Multi-domain]  Cd Length: 289  Bit Score: 39.61  E-value: 1.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105 198 HFTEKLTVDMLAEQANMSTSAFHKAFKQVTQHSPLQYLKVVRLHKAKQLLQNADQSVAQAAYAVGYQSSSQFSREFKKQF 277
Cdd:PRK15121  17 HLDQPLSLDNVAAKAGYSKWHLQRMFKDVTGHAIGAYIRARRLSKAAVALRLTSRPILDIALQYRFDSQQTFTRAFKKQF 96


                 ....
gi 696297105 278 GFPP 281
Cdd:PRK15121  97 AQTP 100
PRK10130 PRK10130
HTH-type transcriptional regulator EutR;
173-281 2.25e-03

HTH-type transcriptional regulator EutR;


Pssm-ID: 182258 [Multi-domain]  Cd Length: 350  Bit Score: 39.13  E-value: 2.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696297105 173 ADALKGLVAQGNLRPIYKICEYIQHHFTEKLTVDMLAEQANMSTSAFHKAFKQVTQHSPLQYLKVVRLHKAKQLL---QN 249
Cdd:PRK10130 227 MVTAESISHQSYRRLLSRAREYVLENMSEPVTVLDLCNQLHVSRRTLQNAFHAILGIGPNAWLKRIRLNAVRRELispWS 306

                         90       100       110
                 ....*....|....*....|....*....|..
gi 696297105 250 ADQSVAQAAYAVGYQSSSQFSREFKKQFGFPP 281
Cdd:PRK10130 307 QSTTVKDAAMQWGFWHLGQFATDYQQLFAEKP 338
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 246-282 8.46e-03

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 33.67  E-value: 8.46e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 696297105  246 LLQNADQ--SVAQAAYAVGYqSSSQFSREFKKQFGFPPK 282
Cdd:pfam00165   1 LRENLSTnlTIADIADELGF-SRSYFSRLFKKYTGVTPS 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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