|
Name |
Accession |
Description |
Interval |
E-value |
| dkgB |
PRK11172 |
2,5-didehydrogluconate reductase DkgB; |
1-267 |
0e+00 |
|
2,5-didehydrogluconate reductase DkgB;
Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 571.58 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 1 MTLPAFGLGTFRLKDDVVIASVKTALELGYRAVDTAQIYENEAAVGQALEESGVPRNELFITTKIWIENLSKDKLIPSLK 80
Cdd:PRK11172 1 MSIPAFGLGTFRLKDQVVIDSVKTALELGYRAIDTAQIYDNEAAVGQAIAESGVPRDELFITTKIWIDNLAKDKLIPSLK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 81 ESLKKLRTDYVDLTLIHWPSPNDAVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIAAVGAENIATNQIELSPYLQ 160
Cdd:PRK11172 81 ESLQKLRTDYVDLTLIHWPSPNDEVSVEEFMQALLEAKKQGLTREIGISNFTIALMKQAIAAVGAENIATNQIELSPYLQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 161 NRKVVDWAKQNGIHITSYMTLAYGKALKDEVITRIAEKHNATAAQVILAWAMGEGYAVIPSSTKRENLASNLLAADLHLD 240
Cdd:PRK11172 161 NRKVVAFAKEHGIHVTSYMTLAYGKVLKDPVIARIAAKHNATPAQVILAWAMQLGYSVIPSSTKRENLASNLLAQDLQLD 240
|
250 260
....*....|....*....|....*..
gi 697052078 241 ADDKKAIAALECNDRLVSPEGLAPDWD 267
Cdd:PRK11172 241 AEDMAAIAALDRNGRLVSPEGLAPEWD 267
|
|
| AKR_AKR3F2 |
cd19139 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ... |
3-250 |
4.10e-175 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 482.24 E-value: 4.10e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 3 LPAFGLGTFRLKDDVVIASVKTALELGYRAVDTAQIYENEAAVGQALEESGVPRNELFITTKIWIENLSKDKLIPSLKES 82
Cdd:cd19139 1 IPAFGLGTFRLKDDVVIDSVRTALELGYRHIDTAQIYDNEAAVGQAIAESGVPRDELFITTKIWIDNLSKDKLLPSLEES 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 83 LKKLRTDYVDLTLIHWPSPNDAVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIAAVGAENIATNQIELSPYLQNR 162
Cdd:cd19139 81 LEKLRTDYVDLTLIHWPSPNDEVPVEEYIGALAEAKEQGLTRHIGVSNFTIALLDEAIAVVGAGAIATNQIELSPYLQNR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 163 KVVDWAKQNGIHITSYMTLAYGKALKDEVITRIAEKHNATAAQVILAWAMGEGYAVIPSSTKRENLASNLLAADLHLDAD 242
Cdd:cd19139 161 KLVAHCKQHGIHVTSYMTLAYGKVLDDPVLAAIAERHGATPAQIALAWAMARGYAVIPSSTKREHLRSNLLALDLTLDAD 240
|
....*...
gi 697052078 243 DKKAIAAL 250
Cdd:cd19139 241 DMAAIAAL 248
|
|
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
1-256 |
2.54e-135 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 382.10 E-value: 2.54e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 1 MTLPAFGLGTFRLKDDVVIASVKTALELGYRAVDTAQIYENEAAVGQALEESGVPRNELFITTKIWIENLSKDKLIPSLK 80
Cdd:COG0656 3 VEIPALGLGTWQLPGEEAAAAVRTALEAGYRHIDTAAMYGNEEGVGEAIAASGVPREELFVTTKVWNDNHGYDDTLAAFE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 81 ESLKKLRTDYVDLTLIHWPSPNDavsVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIAAVGaENIATNQIELSPYLQ 160
Cdd:COG0656 83 ESLERLGLDYLDLYLIHWPGPGP---YVETWRALEELYEEGLIRAIGVSNFDPEHLEELLAETG-VKPAVNQVELHPYLQ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 161 NRKVVDWAKQNGIHITSYMTLAYGKALKDEVITRIAEKHNATAAQVILAWAMGEGYAVIPSSTKRENLASNLLAADLHLD 240
Cdd:COG0656 159 QRELLAFCREHGIVVEAYSPLGRGKLLDDPVLAEIAEKHGKTPAQVVLRWHLQRGVVVIPKSVTPERIRENLDAFDFELS 238
|
250
....*....|....*.
gi 697052078 241 ADDKKAIAALECNDRL 256
Cdd:COG0656 239 DEDMAAIDALDRGERL 254
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
3-247 |
2.46e-122 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 348.49 E-value: 2.46e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 3 LPAFGLGTFRLKDDVVIASVKTALELGYRAVDTAQIYENEAAVGQALEESGVPRNELFITTKIWIENLSKDKLIPSLKES 82
Cdd:cd19073 1 IPALGLGTWQLRGDDCANAVKEALELGYRHIDTAEIYNNEAEVGEAIAESGVPREDLFITTKVWRDHLRPEDLKKSVDRS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 83 LKKLRTDYVDLTLIHWPSPndAVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIAAVGaENIATNQIELSPYLQNR 162
Cdd:cd19073 81 LEKLGTDYVDLLLIHWPNP--TVPLEETLGALKELKEAGKVKSIGVSNFTIELLEEALDISP-LPIAVNQVEFHPFLYQA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 163 KVVDWAKQNGIHITSYMTLAYGKALKDEVITRIAEKHNATAAQVILAWAMGEGYAVIPSSTKRENLASNLLAADLHLDAD 242
Cdd:cd19073 158 ELLEYCRENDIVITAYSPLARGEVLRDPVIQEIAEKYDKTPAQVALRWLVQKGIVVIPKASSEDHLKENLAIFDWELTSE 237
|
....*
gi 697052078 243 DKKAI 247
Cdd:cd19073 238 DVAKI 242
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
2-250 |
5.53e-110 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 317.66 E-value: 5.53e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 2 TLPAFGLGTFRLKDDVVIASVKTALELGYRAVDTAQIYENEAAVGQALEESGVPRNELFITTKIWIENLSKDKLIPSLKE 81
Cdd:cd19140 7 RIPALGLGTYPLTGEECTRAVEHALELGYRHIDTAQMYGNEAQVGEAIAASGVPRDELFLTTKVWPDNYSPDDFLASVEE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 82 SLKKLRTDYVDLTLIHWPSPNdaVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIAAVGAEnIATNQIELSPYLQN 161
Cdd:cd19140 87 SLRKLRTDYVDLLLLHWPNKD--VPLAETLGALNEAQEAGLARHIGVSNFTVALLREAVELSEAP-LFTNQVEYHPYLDQ 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 162 RKVVDWAKQNGIHITSYMTLAYGKALKDEVITRIAEKHNATAAQVILAWAM-GEGYAVIPSSTKRENLASNLLAADLHLD 240
Cdd:cd19140 164 RKLLDAAREHGIALTAYSPLARGEVLKDPVLQEIGRKHGKTPAQVALRWLLqQEGVAAIPKATNPERLEENLDIFDFTLS 243
|
250
....*....|
gi 697052078 241 ADDKKAIAAL 250
Cdd:cd19140 244 DEEMARIAAL 253
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
3-248 |
3.75e-104 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 302.86 E-value: 3.75e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 3 LPAFGLGTFRLKDDVVIASVKTALELGYRAVDTAQIYENEAAVGQALEESGVPRNELFITTKIWIENLSKDKLIPSLKES 82
Cdd:cd19071 1 MPLIGLGTYKLKPEETAEAVLAALEAGYRHIDTAAAYGNEAEVGEAIRESGVPREELFITTKLWPTDHGYERVREALEES 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 83 LKKLRTDYVDLTLIHWPSPNDAVSVEEFM----QALLEAKKQGLTREIGISNFTIPLMEKaIAAVGAENIATNQIELSPY 158
Cdd:cd19071 81 LKDLGLDYLDLYLIHWPVPGKEGGSKEARletwRALEELVDEGLVRSIGVSNFNVEHLEE-LLAAARIKPAVNQIELHPY 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 159 LQNRKVVDWAKQNGIHITSYMTLA--YGKALKDEVITRIAEKHNATAAQVILAWAMGEGYAVIPSSTKRENLASNLLAAD 236
Cdd:cd19071 160 LQQKELVEFCKEHGIVVQAYSPLGrgRRPLLDDPVLKEIAKKYGKTPAQVLLRWALQRGVVVIPKSSNPERIKENLDVFD 239
|
250
....*....|..
gi 697052078 237 LHLDADDKKAIA 248
Cdd:cd19071 240 FELSEEDMAAID 251
|
|
| AKR_AKR5C2 |
cd19131 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ... |
1-251 |
1.02e-85 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 256.15 E-value: 1.02e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 1 MTLPAFGLGTFRLKDDVVIASVKTALELGYRAVDTAQIYENEAAVGQALEESGVPRNELFITTKIWIENLSKDKLIPSLK 80
Cdd:cd19131 8 NTIPQLGLGVWQVSNDEAASAVREALEVGYRSIDTAAIYGNEEGVGKAIRASGVPREELFITTKLWNSDQGYDSTLRAFD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 81 ESLKKLRTDYVDLTLIHWPSPNDAVSVEEFmQALLEAKKQGLTREIGISNFTIPLMEKAIAAVGAENiATNQIELSPYLQ 160
Cdd:cd19131 88 ESLRKLGLDYVDLYLIHWPVPAQDKYVETW-KALIELKKEGRVKSIGVSNFTIEHLQRLIDETGVVP-VVNQIELHPRFQ 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 161 NRKVVDWAKQNGIHITSYMTLAYGKALKDEVITRIAEKHNATAAQVILAWAMGEGYAVIPSSTKRENLASNLLAADLHLD 240
Cdd:cd19131 166 QRELRAFHAKHGIQTESWSPLGQGGLLSDPVIGEIAEKHGKTPAQVVIRWHLQNGLVVIPKSVTPSRIAENFDVFDFELD 245
|
250
....*....|.
gi 697052078 241 ADDKKAIAALE 251
Cdd:cd19131 246 ADDMQAIAGLD 256
|
|
| AKR_AKR3G1 |
cd19123 |
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ... |
2-257 |
4.75e-84 |
|
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.
Pssm-ID: 381349 [Multi-domain] Cd Length: 297 Bit Score: 253.49 E-value: 4.75e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 2 TLPAFGLGTFRLKDDVVIASVKTALELGYRAVDTAQIYENEAAVGQAL----EESGVPRNELFITTKIWIENLSKDKLIP 77
Cdd:cd19123 11 LIPALGLGTWKSKPGEVGQAVKQALEAGYRHIDCAAIYGNEAEIGAALaevfKEGKVKREDLWITSKLWNNSHAPEDVLP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 78 SLKESLKKLRTDYVDLTLIHWP-----------SPNDAVS-----VEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIA 141
Cdd:cd19123 91 ALEKTLADLQLDYLDLYLMHWPvalkkgvgfpeSGEDLLSlspipLEDTWRAMEELVDKGLCRHIGVSNFSVKKLEDLLA 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 142 AvGAENIATNQIELSPYLQNRKVVDWAKQNGIHITSYMTLAYG------------KALKDEVITRIAEKHNATAAQVILA 209
Cdd:cd19123 171 T-ARIKPAVNQVELHPYLQQPELLAFCRDNGIHLTAYSPLGSGdrpaamkaegepVLLEDPVINKIAEKHGASPAQVLIA 249
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 697052078 210 WAMGEGYAVIPSSTKRENLASNLLAADLHLDADDKKAIAALECNDRLV 257
Cdd:cd19123 250 WAIQRGTVVIPKSVNPERIQQNLEAAEVELDASDMATIAALDRHHRYV 297
|
|
| AKR_AKR5D1_E1 |
cd19132 |
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ... |
2-251 |
4.34e-83 |
|
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 249.49 E-value: 4.34e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 2 TLPAFGLGTFRLKDDVVIASVKTALELGYRAVDTAQIYENEAAVGQALEESGVPRNELFITTKIWIENLSKDKLIPSLKE 81
Cdd:cd19132 6 QIPAIGFGTYPLKGDEGVEAVVAALQAGYRLLDTAFNYENEGAVGEAVRRSGVPREELFVTTKLPGRHHGYEEALRTIEE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 82 SLKKLRTDYVDLTLIHWPSPNDAVSVEEFmQALLEAKKQGLTREIGISNFTIPLMEKAIAAVGaENIATNQIELSPYLQN 161
Cdd:cd19132 86 SLYRLGLDYVDLYLIHWPNPSRDLYVEAW-QALIEAREEGLVRSIGVSNFLPEHLDRLIDETG-VTPAVNQIELHPYFPQ 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 162 RKVVDWAKQNGIHITSYMTLAYGKA-LKDEVITRIAEKHNATAAQVILAWAMGEGYAVIPSSTKRENLASNLLAADLHLD 240
Cdd:cd19132 164 AEQRAYHREHGIVTQSWSPLGRGSGlLDEPVIKAIAEKHGKTPAQVVLRWHVQLGVVPIPKSANPERQRENLAIFDFELS 243
|
250
....*....|.
gi 697052078 241 ADDKKAIAALE 251
Cdd:cd19132 244 DEDMAAIAALD 254
|
|
| AKR_DrGR-like |
cd19136 |
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ... |
3-250 |
2.58e-80 |
|
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).
Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 242.54 E-value: 2.58e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 3 LPAFGLGTFRLKD-DVVIASVKTALELGYRAVDTAQIYENEAAVGQALEES----GVPRNELFITTKIWIENLSKDKLIP 77
Cdd:cd19136 1 MPILGLGTFRLRGeEEVRQAVDAALKAGYRLIDTASVYRNEADIGKALRDLlpkyGLSREDIFITSKLAPKDQGYEKARA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 78 SLKESLKKLRTDYVDLTLIHWP-----SPNDAVSVE---EFMQALLEAKKQGLTREIGISNFTIPLMEKAIA------AV 143
Cdd:cd19136 81 ACLGSLERLGTDYLDLYLIHWPgvqglKPSDPRNAElrrESWRALEDLYKEGKLRAIGVSNYTVRHLEELLKycevppAV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 144 gaeniatNQIELSPYLQNRKVVDWAKQNGIHITSYMTLAYG--KALKDEVITRIAEKHNATAAQVILAWAMGEGYAVIPS 221
Cdd:cd19136 161 -------NQVEFHPHLVQKELLKFCKDHGIHLQAYSSLGSGdlRLLEDPTVLAIAKKYGRTPAQVLLRWALQQGIGVIPK 233
|
250 260
....*....|....*....|....*....
gi 697052078 222 STKRENLASNLLAADLHLDADDKKAIAAL 250
Cdd:cd19136 234 STNPERIAENIKVFDFELSEEDMAELNAL 262
|
|
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
4-250 |
1.56e-77 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 235.16 E-value: 1.56e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 4 PAFGLGTFRLKDDVVI-ASVKTALELGYRAVDTAQIYENEAAVGQALEESGVPRNELFITTKIWIENLSKDKLIPSLKES 82
Cdd:cd19133 10 PILGFGVFQIPDPEECeRAVLEAIKAGYRLIDTAAAYGNEEAVGRAIKKSGIPREELFITTKLWIQDAGYEKAKKAFERS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 83 LKKLRTDYVDLTLIHWPSPNdavsVEEFMQALLEAKKQGLTREIGISNFTiP--LMEkaIAAVGAENIATNQIELSPYLQ 160
Cdd:cd19133 90 LKRLGLDYLDLYLIHQPFGD----VYGAWRAMEELYKEGKIRAIGVSNFY-PdrLVD--LILHNEVKPAVNQIETHPFNQ 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 161 NRKVVDWAKQNGIHITSYMTLAYGK--ALKDEVITRIAEKHNATAAQVILAWAMGEGYAVIPSSTKRENLASNLLAADLH 238
Cdd:cd19133 163 QIEAVEFLKKYGVQIEAWGPFAEGRnnLFENPVLTEIAEKYGKSVAQVILRWLIQRGIVVIPKSVRPERIAENFDIFDFE 242
|
250
....*....|..
gi 697052078 239 LDADDKKAIAAL 250
Cdd:cd19133 243 LSDEDMEAIAAL 254
|
|
| AKR_AKR5G1-3 |
cd19157 |
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ... |
3-265 |
1.20e-76 |
|
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 233.44 E-value: 1.20e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 3 LPAFGLGTFRLKDD-VVIASVKTALELGYRAVDTAQIYENEAAVGQALEESGVPRNELFITTKIWIENLSKDKLIPSLKE 81
Cdd:cd19157 10 MPWLGLGVFKVEEGsEVVNAVKTALKNGYRSIDTAAIYGNEEGVGKGIKESGIPREELFITSKVWNADQGYDSTLKAFEA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 82 SLKKLRTDYVDLTLIHWPSPNdavSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIAAvgAENI-ATNQIELSPYLQ 160
Cdd:cd19157 90 SLERLGLDYLDLYLIHWPVKG---KYKETWKALEKLYKDGRVRAIGVSNFQVHHLEDLLAD--AEIVpMVNQVEFHPRLT 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 161 NRKVVDWAKQNGIHITSYMTLAYGKALKDEVITRIAEKHNATAAQVILAWAMGEGYAVIPSSTKRENLASNLLAADLHLD 240
Cdd:cd19157 165 QKELRDYCKKQGIQLEAWSPLMQGQLLDNPVLKEIAEKYNKSVAQVILRWDLQNGVVTIPKSIKEHRIIENADVFDFELS 244
|
250 260
....*....|....*....|....*
gi 697052078 241 ADDKKAIAALECNDRLvspeGLAPD 265
Cdd:cd19157 245 QEDMDKIDALNENLRV----GPDPD 265
|
|
| AKR_AKR2E1-5 |
cd19116 |
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ... |
2-257 |
2.20e-73 |
|
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.
Pssm-ID: 381342 [Multi-domain] Cd Length: 292 Bit Score: 226.01 E-value: 2.20e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 2 TLPAFGLGTFRLKDDV-VIASVKTALELGYRAVDTAQIYENEAAVGQAL----EESGVPRNELFITTKIWIENLSKDKLI 76
Cdd:cd19116 10 EIPAIALGTWKLKDDEgVRQAVKHAIEAGYRHIDTAYLYGNEAEVGEAIrekiAEGVVKREDLFITTKLWNSYHEREQVE 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 77 PSLKESLKKLRTDYVDLTLIHWP----------SPNDAVSVE----EFMQALLEAKKQGLTREIGISNFTIPLMEKAIAA 142
Cdd:cd19116 90 PALRESLKRLGLDYVDLYLIHWPvafkenndseSNGDGSLSDidylETWRGMEDLVKLGLTRSIGVSNFNSEQINRLLSN 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 143 VgaeNI--ATNQIELSPYLQNRKVVDWAKQNGIHITSYMTLAYGKA---------LKDEVITRIAEKHNATAAQVILAWA 211
Cdd:cd19116 170 C---NIkpAVNQIEVHPTLTQEKLVAYCQSNGIVVMAYSPFGRLVPrgqtnppprLDDPTLVAIAKKYGKTTAQIVLRYL 246
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 697052078 212 MGEGYAVIPSSTKRENLASNLLAADLHLDADDKKAIAALECNDRLV 257
Cdd:cd19116 247 IDRGVVPIPKSSNKKRIKENIDIFDFQLTPEEVAALNSFNTNQRVY 292
|
|
| AKR_AKR5C1 |
cd19130 |
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ... |
2-251 |
9.17e-73 |
|
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.
Pssm-ID: 381356 [Multi-domain] Cd Length: 256 Bit Score: 223.25 E-value: 9.17e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 2 TLPAFGLGTFRLKDDVVIASVKTALELGYRAVDTAQIYENEAAVGQALEESGVPRNELFITTKIWIENLSKDKLIPSLKE 81
Cdd:cd19130 9 SIPQLGYGVFKVPPADTQRAVATALEVGYRHIDTAAIYGNEEGVGAAIAASGIPRDELFVTTKLWNDRHDGDEPAAAFAE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 82 SLKKLRTDYVDLTLIHWPSP--NDAVSVEEFMQALLEAkkqGLTREIGISNFTIPLMEKAIAAVGAENiATNQIELSPYL 159
Cdd:cd19130 89 SLAKLGLDQVDLYLVHWPTPaaGNYVHTWEAMIELRAA---GRTRSIGVSNFLPPHLERIVAATGVVP-AVNQIELHPAY 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 160 QNRKVVDWAKQNGIHITSYMTLAYGKALKDEVITRIAEKHNATAAQVILAWAMGEGYAVIPSSTKRENLASNLLAADLHL 239
Cdd:cd19130 165 QQRTIRDWAQAHDVKIEAWSPLGQGKLLGDPPVGAIAAAHGKTPAQIVLRWHLQKGHVVFPKSVRRERMEDNLDVFDFDL 244
|
250
....*....|..
gi 697052078 240 DADDKKAIAALE 251
Cdd:cd19130 245 TDTEIAAIDALD 256
|
|
| dkgA |
PRK11565 |
2,5-didehydrogluconate reductase DkgA; |
3-265 |
1.70e-72 |
|
2,5-didehydrogluconate reductase DkgA;
Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 223.03 E-value: 1.70e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 3 LPAFGLGTFRLKDDVVIASVKTALELGYRAVDTAQIYENEAAVGQALEESGVPRNELFITTKIWienlSKDKLIP--SLK 80
Cdd:PRK11565 15 MPQLGLGVWQASNEEVITAIHKALEVGYRSIDTAAIYKNEEGVGKALKEASVAREELFITTKLW----NDDHKRPreALE 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 81 ESLKKLRTDYVDLTLIHWPSPNDAVSVEEFmQALLEAKKQGLTREIGISNFTIPLMEKAIAAVGAENiATNQIELSPYLQ 160
Cdd:PRK11565 91 ESLKKLQLDYVDLYLMHWPVPAIDHYVEAW-KGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTP-VINQIELHPLMQ 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 161 NRKVVDWAKQNGIHITSYMTLAY-GKALKD-EVITRIAEKHNATAAQVILAWAMGEGYAVIPSSTKRENLASNLLAADLH 238
Cdd:PRK11565 169 QRQLHAWNATHKIQTESWSPLAQgGKGVFDqKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVFDFR 248
|
250 260
....*....|....*....|....*..
gi 697052078 239 LDADDKKAIAALECNDRLvspeGLAPD 265
Cdd:PRK11565 249 LDKDELGEIAKLDQGKRL----GPDPD 271
|
|
| AKR_AKR5A_5G |
cd19126 |
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ... |
3-251 |
4.29e-72 |
|
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 221.54 E-value: 4.29e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 3 LPAFGLGTFRLKD-DVVIASVKTALELGYRAVDTAQIYENEAAVGQALEESGVPRNELFITTKIWIENLSKDKLIPSLKE 81
Cdd:cd19126 9 MPWLGLGVFQTPDgDETERAVQTALENGYRSIDTAAIYKNEEGVGEAIRESGVPREELFVTTKLWNDDQRARRTEDAFQE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 82 SLKKLRTDYVDLTLIHWPSPNDAVSVEEFMQALLEAKKqglTREIGISNFTIPLMEKaIAAVGAENIATNQIELSPYLQN 161
Cdd:cd19126 89 SLDRLGLDYVDLYLIHWPGKDKFIDTWKALEKLYASGK---VKAIGVSNFQEHHLEE-LLAHADVVPAVNQVEFHPYLTQ 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 162 RKVVDWAKQNGIHITSYMTLAYGKALKDEVITRIAEKHNATAAQVILAWAMGEGYAVIPSSTKRENLASNLLAADLHLDA 241
Cdd:cd19126 165 KELRGYCKSKGIVVEAWSPLGQGGLLSNPVLAAIGEKYGKSAAQVVLRWDIQHGVVTIPKSVHASRIKENADIFDFELSE 244
|
250
....*....|
gi 697052078 242 DDKKAIAALE 251
Cdd:cd19126 245 DDMTAIDALN 254
|
|
| AKR_AKR5H1 |
cd19134 |
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ... |
2-256 |
2.63e-71 |
|
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.
Pssm-ID: 381360 [Multi-domain] Cd Length: 263 Bit Score: 219.73 E-value: 2.63e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 2 TLPAFGLGTFRLKDDVVIASVKTALELGYRAVDTAQIYENEAAVGQALEESGVPRNELFITTKIWIENLSKDKLIPSLKE 81
Cdd:cd19134 10 TMPVIGLGVGELSDDEAERSVSAALEAGYRLIDTAAAYGNEAAVGRAIAASGIPRGELFVTTKLATPDQGFTASQAACRA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 82 SLKKLRTDYVDLTLIHWPSPNDAVSVEEFmQALLEAKKQGLTREIGISNFTIPLMEKAIAAVGaENIATNQIELSPYLQN 161
Cdd:cd19134 90 SLERLGLDYVDLYLIHWPAGREGKYVDSW-GGLMKLREEGLARSIGVSNFTAEHLENLIDLTF-FTPAVNQIELHPLLNQ 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 162 RKVVDWAKQNGIHITSYMTLAYGKALKDEVITRIAEKHNATAAQVILAWAMGEGYAVIPSSTKRENLASNLLAADLHLDA 241
Cdd:cd19134 168 AELRKVNAQHGIVTQAYSPLGVGRLLDNPAVTAIAAAHGRTPAQVLLRWSLQLGNVVISRSSNPERIASNLDVFDFELTA 247
|
250
....*....|....*
gi 697052078 242 DDKKAIAALECNDRL 256
Cdd:cd19134 248 DHMDALDGLDDGTRF 262
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
2-247 |
2.79e-70 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 217.10 E-value: 2.79e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 2 TLPAFGLGTFRL---------KDDVVIASVKTALELGYRAVDTAQIY---ENEAAVGQALEesGVPRNELFITTKIWIEN 69
Cdd:cd19072 3 EVPVLGLGTWGIgggmskdysDDKKAIEALRYAIELGINLIDTAEMYgggHAEELVGKAIK--GFDREDLFITTKVSPDH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 70 LSKDKLIPSLKESLKKLRTDYVDLTLIHWpsPNDAVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIAAVGAENIA 149
Cdd:cd19072 81 LKYDDVIKAAKESLKRLGTDYIDLYLIHW--PNPSIPIEETLRAMEELVEEGKIRYIGVSNFSLEELEEAQSYLKKGPIV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 150 TNQIELSpyLQNRKVVD----WAKQNGIHITSYMTLAYGKALKDE---VITRIAEKHNATAAQVILAWAMG-EGYAVIPS 221
Cdd:cd19072 159 ANQVEYN--LFDREEESgllpYCQKNGIAIIAYSPLEKGKLSNAKgspLLDEIAKKYGKTPAQIALNWLISkPNVIAIPK 236
|
250 260
....*....|....*....|....*.
gi 697052078 222 STKRENLASNLLAADLHLDADDKKAI 247
Cdd:cd19072 237 ASNIEHLEENAGALGWELSEEDLQRL 262
|
|
| AKR_AKR5B1 |
cd19127 |
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ... |
2-250 |
3.49e-68 |
|
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.
Pssm-ID: 381353 [Multi-domain] Cd Length: 268 Bit Score: 211.88 E-value: 3.49e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 2 TLPAFGLGTFRLKDDVVIASVKTALELGYRAVDTAQIYENEAAVGQALEESGVPRNELFITTKIWIENLSKDKLIPSLKE 81
Cdd:cd19127 8 EMPALGLGVFQTPPEETADAVATALADGYRLIDTAAAYGNEREVGEGIRRSGVDRSDIFVTTKLWISDYGYDKALRGFDA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 82 SLKKLRTDYVDLTLIHWPSPNDAVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIAAVGAENiATNQIELSPYLQN 161
Cdd:cd19127 88 SLRRLGLDYVDLYLLHWPVPNDFDRTIQAYKALEKLLAEGRVRAIGVSNFTPEHLERLIDATTVVP-AVNQVELHPYFSQ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 162 RKVVDWAKQNGIHITSYMTLA----YGKA--------LKDEVITRIAEKHNATAAQVILAWAMGEGYAVIPSSTKRENLA 229
Cdd:cd19127 167 KDLRAFHRRLGIVTQAWSPIGgvmrYGASgptgpgdvLQDPTITGLAEKYGKTPAQIVLRWHLQNGVSAIPKSVHPERIA 246
|
250 260
....*....|....*....|.
gi 697052078 230 SNLLAADLHLDADDKKAIAAL 250
Cdd:cd19127 247 ENIDIFDFALSAEDMAAIDAL 267
|
|
| AKR_AKR4C1-15 |
cd19125 |
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ... |
2-251 |
1.07e-67 |
|
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.
Pssm-ID: 381351 [Multi-domain] Cd Length: 287 Bit Score: 211.44 E-value: 1.07e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 2 TLPAFGLGTFRLKDDVVIASVKTALELGYRAVDTAQIYENEAAVGQALEESG----VPRNELFITTKIWIENLSKDKLIP 77
Cdd:cd19125 10 KIPAVGLGTWQADPGVVGNAVKTAIKEGYRHIDCAAIYGNEKEIGKALKKLFedgvVKREDLFITSKLWCTDHAPEDVPP 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 78 SLKESLKKLRTDYVDLTLIHWP---------------SPNDAVSVEEFMQALLEAkkqGLTREIGISNFTIPLMEKAIAA 142
Cdd:cd19125 90 ALEKTLKDLQLDYLDLYLIHWPvrlkkgahmpepeevLPPDIPSTWKAMEKLVDS---GKVRAIGVSNFSVKKLEDLLAV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 143 vgAENI-ATNQIELSPYLQNRKVVDWAKQNGIHITSY-------MTLAYGKALKDEVITRIAEKHNATAAQVILAWAMGE 214
Cdd:cd19125 167 --ARVPpAVNQVECHPGWQQDKLHEFCKSKGIHLSAYsplgspgTTWVKKNVLKDPIVTKVAEKLGKTPAQVALRWGLQR 244
|
250 260 270
....*....|....*....|....*....|....*..
gi 697052078 215 GYAVIPSSTKRENLASNLLAADLHLDADDKKAIAALE 251
Cdd:cd19125 245 GTSVLPKSTNEERIKENIDVFDWSIPEEDFAKFSSIE 281
|
|
| AKR_AKR3A1-2 |
cd19117 |
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ... |
3-232 |
2.03e-67 |
|
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.
Pssm-ID: 381343 [Multi-domain] Cd Length: 284 Bit Score: 210.43 E-value: 2.03e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 3 LPAFGLGTFRLKDDVVIASVKTALELGYRAVDTAQIYENEAAVGQALEESGVPRNELFITTKIWieNLSKDKLIPSLKES 82
Cdd:cd19117 14 IPAVGLGTWQSKPNEVAKAVEAALKAGYRHIDTAAIYGNEEEVGQGIKDSGVPREEIFITTKLW--CTWHRRVEEALDQS 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 83 LKKLRTDYVDLTLIHWPSPNDAVSVE----------------------EFMQALLeakKQGLTREIGISNFTIPLMEKAI 140
Cdd:cd19117 92 LKKLGLDYVDLYLMHWPVPLDPDGNDflfkkddgtkdhepdwdfiktwELMQKLP---ATGKVKAIGVSNFSIKNLEKLL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 141 AAVGAENI-ATNQIELSPYLQNRKVVDWAKQNGIHITSYMTLAYGKA--LKDEVITRIAEKHNATAAQVILAWAMGEGYA 217
Cdd:cd19117 169 ASPSAKIVpAVNQIELHPLLPQPKLVDFCKSKGIHATAYSPLGSTNAplLKEPVIIKIAKKHGKTPAQVIISWGLQRGYS 248
|
250
....*....|....*
gi 697052078 218 VIPSSTKRENLASNL 232
Cdd:cd19117 249 VLPKSVTPSRIESNF 263
|
|
| AKR_AKR3B1-3 |
cd19118 |
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ... |
2-250 |
6.11e-67 |
|
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.
Pssm-ID: 381344 [Multi-domain] Cd Length: 283 Bit Score: 209.19 E-value: 6.11e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 2 TLPAFGLGTFRLKDDVVIASVKTALELGYRAVDTAQIYENEAAVGQALEES-----GVPRNELFITTKIWIENLSKDKLI 76
Cdd:cd19118 6 KIPAIGLGTWQAEPGEVGAAVKIALKAGYRHLDLAKVYQNQHEVGQALKELlkeepGVKREDLFITSKLWNNSHRPEYVE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 77 PSLKESLKKLRTDYVDLTLIHWP--------------SPND--------AVSVEEFMQALLEAKKQGLTREIGISNFTIP 134
Cdd:cd19118 86 PALDDTLKELGLDYLDLYLIHWPvafkptgdlnpltaVPTNggevdldlSVSLVDTWKAMVELKKTGKVKSIGVSNFSID 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 135 LMEKAIAAVGaENIATNQIELSPYLQNRKVVDWAKQNGIHITSYMTL---AYGKAL--KDEVITRIAEKHNATAAQVILA 209
Cdd:cd19118 166 HLQAIIEETG-VVPAVNQIEAHPLLLQDELVDYCKSKNIHITAYSPLgnnLAGLPLlvQHPEVKAIAAKLGKTPAQVLIA 244
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 697052078 210 WAMGEGYAVIPSSTKRENLASNLlaADLHLDADDKKAIAAL 250
Cdd:cd19118 245 WGIQRGHSVIPKSVTPSRIRSNF--EQVELSDDEFNAVTAL 283
|
|
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
4-249 |
9.88e-67 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 208.24 E-value: 9.88e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 4 PAFGLGT--FRLKDDVV----IASVKTALELGYRAVDTAQIYENEAAVGQALEESGVPRNELFITTKIW--IENLSKdkl 75
Cdd:cd19120 7 IAFGTGTawYKSGDDDIqrdlVDSVKLALKAGFRHIDTAEMYGNEKEVGEALKESGVPREDLFITTKVSpgIKDPRE--- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 76 ipSLKESLKKLRTDYVDLTLIHWP--SPNDAVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKaIAAVGAENIATNQI 153
Cdd:cd19120 84 --ALRKSLAKLGVDYVDLYLIHSPffAKEGGPTLAEAWAELEALKDAGLVRSIGVSNFRIEDLEE-LLDTAKIKPAVNQI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 154 ELSPYLQNR--KVVDWAKQNGIHITSYMTLA-----YGKALkDEVITRIAEKHNATAAQVILAWAMGEGYAVIPSSTKRE 226
Cdd:cd19120 161 EFHPYLYPQqpALLEYCREHGIVVSAYSPLSpltrdAGGPL-DPVLEKIAEKYGVTPAQVLLRWALQKGIVVVTTSSKEE 239
|
250 260
....*....|....*....|...
gi 697052078 227 NLASNLLAADLHLDADDKKAIAA 249
Cdd:cd19120 240 RMKEYLEAFDFELTEEEVEEIDK 262
|
|
| AKR_AKR1G1_CeAKR |
cd19154 |
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ... |
3-256 |
2.12e-66 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 208.42 E-value: 2.12e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 3 LPAFGLGTFRLKDDVVIASVKTALELGYRAVDTAQIYENEAAVGQAL----EESGVPRNELFITTKIWIENLSKDKLIPS 78
Cdd:cd19154 12 MPLIGLGTWQSKGAEGITAVRTALKAGYRLIDTAFLYQNEEAIGEALaellEEGVVKREDLFITTKLWTHEHAPEDVEEA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 79 LKESLKKLRTDYVDLTLIHWPSP-----------------NDAVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEkAIA 141
Cdd:cd19154 92 LRESLKKLQLEYVDLYLIHAPAAfkddegesgtmengmsiHDAVDVEDVWRGMEKVYDEGLTKAIGVSNFNNDQIQ-RIL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 142 AVGAENIATNQIELSPYLQNRKVVDWAKQNGIHITSYMTLAY-GKA--------------LKDEVITRIAEKHNATAAQV 206
Cdd:cd19154 171 DNARVKPHNNQVECHLYFPQKELVEFCKKHNISVTSYATLGSpGRAnftkstgvspapnlLQDPIVKAIAEKHGKTPAQV 250
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 697052078 207 ILAWAMGEGYAVIPSSTKRENLASNLLAADLHLDADDKKAIAALECNDRL 256
Cdd:cd19154 251 LLRYLLQRGIAVIPKSATPSRIKENFNIFDFSLSEEDMATLEEIEKSLRL 300
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
3-243 |
7.69e-64 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 200.63 E-value: 7.69e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 3 LPAFGLGTFRL---KDDVVIASVKtalELGYRAVDTAQIYENEAAVGQALEESGVPRNELFITTKIWIENLSKDKLIPSL 79
Cdd:cd19135 13 MPILGLGTSHSggySHEAVVYALK---ECGYRHIDTAKRYGCEELLGKAIKESGVPREDLFLTTKLWPSDYGYESTKQAF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 80 KESLKKLRTDYVDLTLIHWPSPNDAV-----SVEEFMQALLEAKKQGLTREIGISNFTIP----LMEKAiaavgaeNIA- 149
Cdd:cd19135 90 EASLKRLGVDYLDLYLLHWPDCPSSGknvkeTRAETWRALEELYDEGLCRAIGVSNFLIEhleqLLEDC-------SVVp 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 150 -TNQIELSPYLQNRKVVDWAKQNGIHITSYMTLAYGKALKDEVITRIAEKHNATAAQVILAWAMGEGYAVIPSSTKRENL 228
Cdd:cd19135 163 hVNQVEFHPFQNPVELIEYCRDNNIVFEGYCPLAKGKALEEPTVTELAKKYQKTPAQILIRWSIQNGVVTIPKSTKEERI 242
|
250
....*....|....*
gi 697052078 229 ASNLLAADLHLDADD 243
Cdd:cd19135 243 KENCQVFDFSLSEED 257
|
|
| AKR_AKR5A1_2 |
cd19156 |
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ... |
3-265 |
4.57e-63 |
|
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 198.90 E-value: 4.57e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 3 LPAFGLGTFRLKD-DVVIASVKTALELGYRAVDTAQIYENEAAVGQALEESGVPRNELFITTKIWIENLSKDKLIPSLKE 81
Cdd:cd19156 9 MPRLGLGVWRVQDgAEAENAVKWAIEAGYRHIDTAAIYKNEEGVGQGIRESGVPREEVFVTTKLWNSDQGYESTLAAFEE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 82 SLKKLRTDYVDLTLIHWPSPNDAVSVEEFMQALLEAKKqglTREIGISNFTIPLMEKAIAAVgaeNIA--TNQIELSPYL 159
Cdd:cd19156 89 SLEKLGLDYVDLYLIHWPVKGKFKDTWKAFEKLYKEKK---VRAIGVSNFHEHHLEELLKSC---KVApmVNQIELHPLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 160 QNRKVVDWAKQNGIHITSYMTLAYGKALKDEVITRIAEKHNATAAQVILAWAMGEGYAVIPSSTKRENLASNLLAADLHL 239
Cdd:cd19156 163 TQEPLRKFCKEKNIAVEAWSPLGQGKLLSNPVLKAIGKKYGKSAAQVIIRWDIQHGIITIPKSVHEERIQENFDVFDFEL 242
|
250 260
....*....|....*....|....*.
gi 697052078 240 DADDKKAIAALECNDRLvspeGLAPD 265
Cdd:cd19156 243 TAEEIRQIDGLNTDHRY----GPDPD 264
|
|
| AKR_AKR4A_4B |
cd19124 |
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ... |
2-251 |
2.56e-62 |
|
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.
Pssm-ID: 381350 [Multi-domain] Cd Length: 281 Bit Score: 197.49 E-value: 2.56e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 2 TLPAFGLGT--FRLKDDVVIASVKTALELGYRAVDTAQIYENEAAVGQALEE---SGV--PRNELFITTKIWIENLSKDK 74
Cdd:cd19124 4 TMPVIGMGTasDPPSPEDIKAAVLEAIEVGYRHFDTAAAYGTEEALGEALAEalrLGLvkSRDELFVTSKLWCSDAHPDL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 75 LIPSLKESLKKLRTDYVDLTLIHWP------SPNDAVSVEEFM--------QALLEAKKQGLTREIGISNFTIPLMEK-- 138
Cdd:cd19124 84 VLPALKKSLRNLQLEYVDLYLIHWPvslkpgKFSFPIEEEDFLpfdikgvwEAMEECQRLGLTKAIGVSNFSCKKLQEll 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 139 AIAAVGAeniATNQIELSPYLQNRKVVDWAKQNGIHITSYMTL-AYGKA------LKDEVITRIAEKHNATAAQVILAWA 211
Cdd:cd19124 164 SFATIPP---AVNQVEMNPAWQQKKLREFCKANGIHVTAYSPLgAPGTKwgsnavMESDVLKEIAAAKGKTVAQVSLRWV 240
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 697052078 212 MGEGYAVIPSSTKRENLASNLLAADLHLDADDKKAIAALE 251
Cdd:cd19124 241 YEQGVSLVVKSFNKERMKQNLDIFDWELTEEDLEKISEIP 280
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
3-247 |
2.87e-61 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 193.94 E-value: 2.87e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 3 LPAFGLGTFRL---------KDDVVIASVKTALELGYRAVDTAQIY---ENEAAVGQALEEsgVPRNELFITTKIWIENL 70
Cdd:cd19137 4 IPALGLGTWGIggfltpdysRDEEMVELLKTAIELGYTHIDTAEMYgggHTEELVGKAIKD--FPREDLFIVTKVWPTNL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 71 SKDKLIPSLKESLKKLRTDYVDLTLIHWPSPNdaVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIAAVgAENIAT 150
Cdd:cd19137 82 RYDDLLRSLQNSLRRLDTDYIDLYLIHWPNPN--IPLEETLSAMAEGVRQGLIRYIGVSNFNRRLLEEAISKS-QTPIVC 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 151 NQIELSPY---LQNRKVVDWAKQNGIHITSYMTLAYGKALKDEVITRIAEKHNATAAQVILAWAMGEGYAV-IPSSTKRE 226
Cdd:cd19137 159 NQVKYNLEdrdPERDGLLEYCQKNGITVVAYSPLRRGLEKTNRTLEEIAKNYGKTIAQIALAWLIQKPNVVaIPKAGRVE 238
|
250 260
....*....|....*....|.
gi 697052078 227 NLASNLLAADLHLDADDKKAI 247
Cdd:cd19137 239 HLKENLKATEIKLSEEEMKLL 259
|
|
| AKR_AKR1G1_1I |
cd19111 |
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ... |
3-256 |
2.82e-59 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381337 [Multi-domain] Cd Length: 286 Bit Score: 189.63 E-value: 2.82e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 3 LPAFGLGTFRLKDDVVIASVKTALELGYRAVDTAQIYENEAAVGQA----LEESGVPRNELFITTKIWIENLSKDKLIPS 78
Cdd:cd19111 4 MPVIGLGTYQSPPEEVRAAVDYALFVGYRHIDTALSYQNEKAIGEAlkwwLKNGKLKREEVFITTKLPPVYLEFKDTEKS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 79 LKESLKKLRTDYVDLTLIHWP-----------SPNDAVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKaIAAVGAEN 147
Cdd:cd19111 84 LEKSLENLKLPYVDLYLIHHPcgfvnkkdkgeRELASSDVTSVWRAMEALVSEGKVKSIGLSNFNPRQINK-ILAYAKVK 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 148 IATNQIELSPYLQNRKVVDWAKQNGIHITSYMTL-AYGKA-----------LKDEVITRIAEKHNATAAQVILAWAMGEG 215
Cdd:cd19111 163 PSNLQLECHAYLQQRELRKFCNKKNIVVTAYAPLgSPGRAnqslwpdqpdlLEDPTVLAIAKELDKTPAQVLLRFVLQRG 242
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 697052078 216 YAVIPSSTKRENLASNLLAADLHLDADDKKAIAALECNDRL 256
Cdd:cd19111 243 TGVLPKSTNKERIEENFEVFDFELTEEHFKKLKTLDRNMKY 283
|
|
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
1-247 |
1.23e-58 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 187.46 E-value: 1.23e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 1 MTLPAFGLGTFRLKDDV-----VIASVKTALELGYRAVDTAQIYEN---EAAVGQALEESgvpRNELFITTKIWIENLSK 72
Cdd:cd19138 9 TKVPALGQGTWYMGEDPakraqEIEALRAGIDLGMTLIDTAEMYGDggsEELVGEAIRGR---RDKVFLVSKVLPSNASR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 73 DKLIPSLKESLKKLRTDYVDLTLIHWPSpndAVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIAAVGAENIATNQ 152
Cdd:cd19138 86 QGTVRACERSLRRLGTDYLDLYLLHWRG---GVPLAETVAAMEELKKEGKIRAWGVSNFDTDDMEELWAVPGGGNCAANQ 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 153 IELSpyLQNR----KVVDWAKQNGIHITSYMTLAYG-----KALKDEVITRIAEKHNATAAQVILAWAMGEGYAV-IPSS 222
Cdd:cd19138 163 VLYN--LGSRgieyDLLPWCREHGVPVMAYSPLAQGgllrrGLLENPTLKEIAARHGATPAQVALAWVLRDGNVIaIPKS 240
|
250 260
....*....|....*....|....*
gi 697052078 223 TKRENLASNLLAADLHLDADDKKAI 247
Cdd:cd19138 241 GSPEHARENAAAADLELTEEDLAEL 265
|
|
| AKR_AKR1A1-4 |
cd19106 |
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ... |
2-259 |
1.44e-57 |
|
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.
Pssm-ID: 381332 [Multi-domain] Cd Length: 305 Bit Score: 186.05 E-value: 1.44e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 2 TLPAFGLGTFRLKDDVVIASVKTALELGYRAVDTAQIYENEAAVGQALEES-----GVPRNELFITTKIWIENLSKDKLI 76
Cdd:cd19106 6 KMPLIGLGTWKSKPGQVKAAVKYALDAGYRHIDCAAVYGNEQEVGEALKEKvgpgkAVPREDLFVTSKLWNTKHHPEDVE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 77 PSLKESLKKLRTDYVDLTLIHWPS---------PNDA--------VSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKa 139
Cdd:cd19106 86 PALRKTLKDLQLDYLDLYLIHWPYafergdnpfPKNPdgtirydsTHYKETWKAMEKLVDKGLVKAIGLSNFNSRQIDD- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 140 IAAVGAENIATNQIELSPYLQNRKVVDWAKQNGIHITSYMTL-----AYGKA-----LKDEVITRIAEKHNATAAQVILA 209
Cdd:cd19106 165 ILSVARIKPAVLQVECHPYLAQNELIAHCKARGLVVTAYSPLgspdrPWAKPdepvlLEEPKVKALAKKYNKSPAQILLR 244
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 697052078 210 WAMGEGYAVIPSSTKRENLASNLLAADLHLDADDKKAIAALECNDRLVSP 259
Cdd:cd19106 245 WQVQRGVVVIPKSVTPSRIKQNIQVFDFTLSPEEMKQLDALNRNWRYIVP 294
|
|
| AKR_AKR3D1 |
cd19121 |
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ... |
3-247 |
4.53e-56 |
|
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.
Pssm-ID: 381347 [Multi-domain] Cd Length: 279 Bit Score: 181.19 E-value: 4.53e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 3 LPAFGLGTFRLKDDVVIASVKTALELGYRAVDTAQIYENEAAVGQALEES---GVPRNELFITTKIWieNLSKDKLIPSL 79
Cdd:cd19121 12 IPAVGLGTWQAKAGEVKAAVAHALKIGYRHIDGALCYQNEDEVGEGIKEAiagGVKREDLFVTTKLW--STYHRRVELCL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 80 KESLKKLRTDYVDLTLIHWP---SPN--------------------DAVSVEEFMQALLeakKQGLTREIGISNFTIPLM 136
Cdd:cd19121 90 DRSLKSLGLDYVDLYLVHWPvllNPNgnhdlfptlpdgsrdldwdwNHVDTWKQMEKVL---KTGKTKAIGVSNYSIPYL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 137 EKAIAAvgAENI-ATNQIELSPYLQNRKVVDWAKQNGIHITSYMTL--AYGKALKDEVITRIAEKHNATAAQVILAWAMG 213
Cdd:cd19121 167 EELLKH--ATVVpAVNQVENHPYLPQQELVDFCKEKGILIEAYSPLgsTGSPLISDEPVVEIAKKHNVGPGTVLISYQVA 244
|
250 260 270
....*....|....*....|....*....|....
gi 697052078 214 EGYAVIPSSTKRENLASNLLAADlhLDADDKKAI 247
Cdd:cd19121 245 RGAVVLPKSVTPDRIKSNLEIID--LDDEDMNKL 276
|
|
| AKR_AKR2C1 |
cd19114 |
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ... |
3-260 |
1.21e-54 |
|
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.
Pssm-ID: 381340 [Multi-domain] Cd Length: 302 Bit Score: 178.52 E-value: 1.21e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 3 LPAFGLGTFRLKDDVVIASVKTALELGYRAVDTAQIYENEAAVG----QALEESGVPRNELFITTKIWIENLSKDKLIPS 78
Cdd:cd19114 4 MPLVGFGTAKIKANETEEVIYNAIKVGYRLIDGALLYGNEAEVGrgirKAIQEGLVKREDLFIVTKLWNNFHGKDHVREA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 79 LKESLKKLRTDYVDLTLIHWPSPN---DAVSVEEFMQALLEAKK--------------------QGLTREIGISNFTIPL 135
Cdd:cd19114 84 FDRQLKDYGLDYIDLYLIHFPIPAayvDPAENYPFLWKDKELKKfpleqspmqecwremeklvdAGLVRNIGIANFNVQL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 136 MEKAIAAVGAENiATNQIELSPYLQNRKVVDWAKQNGIHITSYMTLA-------------YGKALKDEVITRIAEKHNAT 202
Cdd:cd19114 164 ILDLLTYAKIKP-AVLQIEHHPYLQQKRLIDWAKKQGIQITAYSSFGnavytkvtkhlkhFTNLLEHPVVKKLADKHKRD 242
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 697052078 203 AAQVILAWAMGEGYAVIPSSTKRENLASNLLAADLHLDADDKKAIAALECNDRLVSPE 260
Cdd:cd19114 243 TGQVLLRWAVQRNITVIPKSVNVERMKTNLDITSYKLDEEDMEALYELEANARFNDPV 300
|
|
| AKR_AKR2B1-10 |
cd19113 |
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ... |
3-267 |
3.42e-54 |
|
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.
Pssm-ID: 381339 [Multi-domain] Cd Length: 310 Bit Score: 177.25 E-value: 3.42e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 3 LPAFGLGTFRLKDDVVIASVKTALELGYRAVDTAQIYENEAAVGQ----ALEESGVPRNELFITTKIWIENLSKDKLIPS 78
Cdd:cd19113 11 MPSVGFGCWKLDNATAADQIYQAIKAGYRLFDGAEDYGNEKEVGEgvnrAIDEGLVKREELFLTSKLWNNFHDPKNVETA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 79 LKESLKKLRTDYVDLTLIHWPSPNDAVSVEE-----FM------------------QALLEAKKQGLTREIGISNFTIPL 135
Cdd:cd19113 91 LNKTLSDLKLDYVDLFLIHFPIAFKFVPIEEkyppgFYcgdgdnfvyedvpildtwKALEKLVDAGKIKSIGVSNFPGAL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 136 MEKAIAavGAE-NIATNQIELSPYLQNRKVVDWAKQNGIHITSY--------MTLAYGKAL------KDEVITRIAEKHN 200
Cdd:cd19113 171 ILDLLR--GATiKPAVLQIEHHPYLQQPKLIEYAQKAGITITAYssfgpqsfVELNQGRALntptlfEHDTIKSIAAKHN 248
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 697052078 201 ATAAQVILAWAMGEGYAVIPSSTKRENLASNLLAADLHLDADDKKAIAALECNDRLVSPeglapdWD 267
Cdd:cd19113 249 KTPAQVLLRWATQRGIAVIPKSNLPERLLQNLSVNDFDLTKEDFEEIAKLDIGLRFNDP------WD 309
|
|
| AKR_AKR2A1-2 |
cd19112 |
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ... |
3-260 |
5.74e-53 |
|
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.
Pssm-ID: 381338 [Multi-domain] Cd Length: 308 Bit Score: 174.21 E-value: 5.74e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 3 LPAFGLGTFRLKDDVVIASVKTALELGYRAVDTAQIYENEAAVGQALEESG----VPRNELFITTKIWieNLSKDKLIPS 78
Cdd:cd19112 11 MPVIGLGVWRMEPGEIKELILNAIKIGYRHFDCAADYKNEKEVGEALAEAFktglVKREDLFITTKLW--NSDHGHVIEA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 79 LKESLKKLRTDYVDLTLIHWP---------SPNDA------------VSVEEFMQALLEAKKQGLTREIGISNFTIPLME 137
Cdd:cd19112 89 CKDSLKKLQLDYLDLYLVHFPvatkhtgvgTTGSAlgedgvldidvtISLETTWHAMEKLVSAGLVRSIGISNYDIFLTR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 138 KAIAAVGAENiATNQIELSPYLQNRKVVDWAKQNGIHITSYMTLAYGKA----------LKDEVITRIAEKHNATAAQVI 207
Cdd:cd19112 169 DCLAYSKIKP-AVNQIETHPYFQRDSLVKFCQKHGISVTAHTPLGGAAAnaewfgsvspLDDPVLKDLAKKYGKSAAQIV 247
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 697052078 208 LAWAMGEGYAVIPSSTKRENLASNLLAADLHLDADDKKAIAALECNDRLVSPE 260
Cdd:cd19112 248 LRWGIQRNTAVIPKSSKPERLKENIDVFDFQLSKEDMKLIKSLDRKYRTNQPA 300
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
5-250 |
6.31e-53 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 173.65 E-value: 6.31e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 5 AFGLGTFRLKDDVVIASVKTALELGYRAVDTAQIY---ENEAAVGQALEESGVPRNELFITTKI------WIENLSKDKL 75
Cdd:pfam00248 7 QLGGGWGPISKEEALEALRAALEAGINFIDTAEVYgdgKSEELLGEALKDYPVKRDKVVIATKVpdgdgpWPSGGSKENI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 76 IPSLKESLKKLRTDYVDLTLIHWPSPNdaVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIAAVGAEnIATNQIEL 155
Cdd:pfam00248 87 RKSLEESLKRLGTDYIDLYYLHWPDPD--TPIEETWDALEELKKEGKIRAIGVSNFDAEQIEKALTKGKIP-IVAVQVEY 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 156 SPY--LQNRKVVDWAKQNGIHITSYMTLAYGKALK---------------------------DEVITRIAEKHNATAAQV 206
Cdd:pfam00248 164 NLLrrRQEEELLEYCKKNGIPLIAYSPLGGGLLTGkytrdpdkgpgerrrllkkgtplnleaLEALEEIAKEHGVSPAQV 243
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 697052078 207 ILAWAMGE--GYAVIPSSTKRENLASNLLAADLHLDADDKKAIAAL 250
Cdd:pfam00248 244 ALRWALSKpgVTIPIPGASNPEQLEDNLGALEFPLSDEEVARIDEL 289
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
1-250 |
7.32e-53 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 174.21 E-value: 7.32e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 1 MTLPAFGLGTFRL-------KDDVVIASVKTALELGYRAVDTAQIY---ENEAAVGQALEesGVPRNELFITTKI----- 65
Cdd:COG0667 11 LKVSRLGLGTMTFggpwggvDEAEAIAILDAALDAGINFFDTADVYgpgRSEELLGEALK--GRPRDDVVIATKVgrrmg 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 66 ---WIENLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPNdaVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIA- 141
Cdd:COG0667 89 pgpNGRGLSREHIRRAVEASLRRLGTDYIDLYQLHRPDPD--TPIEETLGALDELVREGKIRYIGVSNYSAEQLRRALAi 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 142 AVGAENIATNQIELSpyLQNRK----VVDWAKQNGIHITSYMTLAYG----KALKD------------------------ 189
Cdd:COG0667 167 AEGLPPIVAVQNEYS--LLDRSaeeeLLPAARELGVGVLAYSPLAGGlltgKYRRGatfpegdraatnfvqgylternla 244
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 697052078 190 --EVITRIAEKHNATAAQVILAWAMGEGY--AVIPSSTKRENLASNLLAADLHLDADDKKAIAAL 250
Cdd:COG0667 245 lvDALRAIAAEHGVTPAQLALAWLLAQPGvtSVIPGARSPEQLEENLAAADLELSAEDLAALDAA 309
|
|
| AKR_GlAR-like |
cd19128 |
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ... |
4-250 |
1.13e-52 |
|
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Pssm-ID: 381354 [Multi-domain] Cd Length: 277 Bit Score: 172.71 E-value: 1.13e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 4 PAFGLGTFRLKDDVVIASVKTALELGYRAVDTAQIYENEAAVGQALEE----SGVPRNELFITTKIWIENLSKDKLIPSL 79
Cdd:cd19128 2 PRLGFGTYKITESESKEAVKNAIKAGYRHIDCAYYYGNEAFIGIAFSEifkdGGVKREDLFITSKLWPTMHQPENVKEQL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 80 KESLKKLRTDYVDLTLIHWP---------SPNDA--------VSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIAA 142
Cdd:cd19128 82 LITLQDLQLEYLDLFLIHWPlafdmdtdgDPRDDnqiqslskKPLEDTWRAMEQCVDEKLTKNIGVSNYSTKLLTDLLNY 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 143 VGAENIaTNQIELSPYLQNRKVVDWAKQNGIHITSYMTL----AYGKA--LKDEVITRIAEKHNATAAQVILAWAMGE-- 214
Cdd:cd19128 162 CKIKPF-MNQIECHPYFQNDKLIKFCIENNIHVTAYRPLggsyGDGNLtfLNDSELKALATKYNTTPPQVIIAWHLQKwp 240
|
250 260 270
....*....|....*....|....*....|....*..
gi 697052078 215 -GYAVIPSSTKRENLASNLLAADLHLDADDKKAIAAL 250
Cdd:cd19128 241 kNYSVIPKSANKSRCQQNFDINDLALTKEDMDAINTL 277
|
|
| AKR_AKR1I_CgAKR1 |
cd19155 |
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ... |
3-256 |
6.75e-51 |
|
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381381 [Multi-domain] Cd Length: 307 Bit Score: 168.86 E-value: 6.75e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 3 LPAFGLGTFRLKDDVVIASVKTALELGYRAVDTAQIYENEAAVGQALEE---SG-VPRNELFITTKIWIENLSKDKLIPS 78
Cdd:cd19155 12 MPVVGLGTWQSSPEEIETAVDTALEAGYRHIDTAYVYRNEAAIGNVLKKwidSGkVKREELFIVTKLPPGGNRREKVEKF 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 79 LKESLKKLRTDYVDLTLIHWP----------------------SPNDAVSVEEFMQALLEakkQGLTREIGISNFTIPLM 136
Cdd:cd19155 92 LLKSLEKLQLDYVDLYLIHFPvgslskeddsgkldptgehkqdYTTDLLDIWKAMEAQVD---QGLTRSIGLSNFNREQM 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 137 EKaIAAVGAENIATNQIELSPYLQNRKVVDWAKQNGIHITSYMTL-----------------AYGKALKDEVITRIAEKH 199
Cdd:cd19155 169 AR-ILKNARIKPANLQVELHVYLQQKDLVDFCSTHSITVTAYAPLgspgaahfspgtgspsgSSPDLLQDPVVKAIAERH 247
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 697052078 200 NATAAQVILAWAMGEGYAVIPSSTKRENLASNLLAADLHLDADDKKAIAALECNDRL 256
Cdd:cd19155 248 GKSPAQVLLRWLMQRGVVVIPKSTNAARIKENFQVFDFELTEADMAKLSSLDKNIRG 304
|
|
| AKR_AKR2D1 |
cd19115 |
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ... |
3-259 |
4.74e-50 |
|
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.
Pssm-ID: 381341 [Multi-domain] Cd Length: 311 Bit Score: 166.83 E-value: 4.74e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 3 LPAFGLGTFRLKDDVVIASVKTALELGYRAVDTAQIYENEAAVGQ----ALEESGVPRNELFITTKIWIENLSKDKLIPS 78
Cdd:cd19115 13 MPLVGFGLWKVNNDTCADQVYNAIKAGYRLFDGACDYGNEVEAGQgvarAIKEGIVKREDLFIVSKLWNTFHDGERVEPI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 79 LKESLKKLRTDYVDLTLIHWP-----------------SPNDAV-----SVEEFMQALLEAKKQGLTREIGISNFTIPLM 136
Cdd:cd19115 93 CRKQLADWGIDYFDLFLIHFPialkyvdpavryppgwfYDGKKVefsnaPIQETWTAMEKLVDKGLARSIGVSNFSAQLL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 137 EKAI--AAVGAeniATNQIELSPYLQNRKVVDWAKQNGIHIT--------SYMTLAYGKA------LKDEVITRIAEKHN 200
Cdd:cd19115 173 MDLLryARIRP---ATLQIEHHPYLTQPRLVKYAQKEGIAVTayssfgpqSFLELDLPGAkdtpplFEHDVIKSIAEKHG 249
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 697052078 201 ATAAQVILAWAMGEGYAVIPSSTKRENLASNLLAADLHLDADDKKAIAALECNDRLVSP 259
Cdd:cd19115 250 KTPAQVLLRWATQRGIAVIPKSNNPKRLAQNLDVTGFDLEAEEIKAISALDIGLRFNNP 308
|
|
| AKR_AKR3C1 |
cd19119 |
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ... |
3-245 |
5.49e-49 |
|
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).
Pssm-ID: 381345 [Multi-domain] Cd Length: 294 Bit Score: 163.44 E-value: 5.49e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 3 LPAFGLGTFRLKDD--VVIASVKTALELGYRAVDTAQIYENEAAVGQAL----EESGVPRNELFITTKIWieNLSKDKLI 76
Cdd:cd19119 12 IPALGLGTASPHEDraEVKEAVEAAIKEGYRHIDTAYAYETEDFVGEAIkraiDDGSIKREELFITTKVW--PTFYDEVE 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 77 PSLKESLKKLRTDYVDLTLIHWPSPNDAVSVE-----------------------EFMQALLEAKKQGLTREIGISNFTI 133
Cdd:cd19119 90 RSLDESLKALGLDYVDLLLVHWPVCFEKDSDDsgkpftpvnddgktryaasgdhiTTYKQLEKIYLDGRAKAIGVSNYSI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 134 PLMEKAIAAVGAENiATNQIELSPYLQNRKVVDWAKQNGIHITSYMTLAYGKA--LKDEVITRIAEKHNATAAQVILAWA 211
Cdd:cd19119 170 VYLERLIKECKVVP-AVNQVELHPHLPQMDLRDFCFKHGILVTAYSPLGSHGApnLKNPLVKKIAEKYNVSTGDILISYH 248
|
250 260 270
....*....|....*....|....*....|....
gi 697052078 212 MGEGYAVIPSSTKRENLASNLLAAdlHLDADDKK 245
Cdd:cd19119 249 VRQGVIVLPKSLKPVRIVSNGKIV--SLTKEDLQ 280
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
15-247 |
6.28e-48 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 160.83 E-value: 6.28e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 15 DDVVIASVKTALELGYRAVDTAQIYEN---EAAVGQALEEsgvPRNELFITTKIWIENLSKDKLIPSLKESLKKLRTDYV 91
Cdd:cd19085 22 DEESIATIHAALDAGINFFDTAEAYGDghsEEVLGKALKG---RRDDVVIATKVSPDNLTPEDVRKSCERSLKRLGTDYI 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 92 DLTLIHWPSPndAVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIAAVgaeNIATNQIelsPY-LQNR----KVVD 166
Cdd:cd19085 99 DLYQIHWPSS--DVPLEETMEALEKLKEEGKIRAIGVSNFGPAQLEEALDAG---RIDSNQL---PYnLLWRaieyEILP 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 167 WAKQNGIHITSYMTLAYG----------------------------------KALkdEVITRIAEKHNATAAQVILAWAM 212
Cdd:cd19085 171 FCREHGIGVLAYSPLAQGlltgkfssaedfppgdartrlfrhfepgaeeetfEAL--EKLKEIADELGVTMAQLALAWVL 248
|
250 260 270
....*....|....*....|....*....|....*..
gi 697052078 213 GEGY--AVIPSSTKRENLASNLLAADLHLDADDKKAI 247
Cdd:cd19085 249 QQPGvtSVIVGARNPEQLEENAAAVDLELSPSVLERL 285
|
|
| AKR_AKR1B1-19 |
cd19107 |
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ... |
3-255 |
1.55e-46 |
|
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.
Pssm-ID: 381333 [Multi-domain] Cd Length: 307 Bit Score: 157.58 E-value: 1.55e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 3 LPAFGLGTFRLKDDVVIASVKTALELGYRAVDTAQIYENEAAVGQALE----ESGVPRNELFITTKIWIENLSKDKLIPS 78
Cdd:cd19107 4 MPILGLGTWKSPPGQVTEAVKVAIDAGYRHIDCAYVYQNENEVGEAIQekikEQVVKREDLFIVSKLWCTFHEKGLVKGA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 79 LKESLKKLRTDYVDLTLIHWPS---------PNDA-----VSVEEFMQ---ALLEAKKQGLTREIGISNFTIPLMEKAIA 141
Cdd:cd19107 84 CQKTLSDLKLDYLDLYLIHWPTgfkpgkelfPLDEsgnviPSDTTFLDtweAMEELVDEGLVKAIGVSNFNHLQIERILN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 142 AVGAE-NIATNQIELSPYLQNRKVVDWAKQNGIHITSYMTLA-----YGKA-----LKDEVITRIAEKHNATAAQVILAW 210
Cdd:cd19107 164 KPGLKyKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGspdrpWAKPedpslLEDPKIKEIAAKHNKTTAQVLIRF 243
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 697052078 211 AMGEGYAVIPSSTKRENLASNLLAADLHLDADDKKAIAALECNDR 255
Cdd:cd19107 244 PIQRNLVVIPKSVTPERIAENFKVFDFELSSEDMATILSFNRNWR 288
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
4-232 |
7.25e-46 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 153.44 E-value: 7.25e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 4 PAFGLGTFRLKDDV----VIASVKTALELGYRAVDTAQIY---ENEAAVGQALEESGVpRNELFITTKI--------WIE 68
Cdd:cd06660 1 SRLGLGTMTFGGDGdeeeAFALLDAALEAGGNFFDTADVYgdgRSERLLGRWLKGRGN-RDDVVIATKGghppggdpSRS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 69 NLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPNdaVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIAAVGAEN- 147
Cdd:cd06660 80 RLSPEHIRRDLEESLRRLGTDYIDLYYLHRDDPS--TPVEETLEALNELVREGKIRYIGVSNWSAERLAEALAYAKAHGl 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 148 --IATNQIELS---PYLQNRKVVDWAKQNGIHITSYMTLAYGkalkdevitriaekhnatAAQVILAWAMGEGY--AVIP 220
Cdd:cd06660 158 pgFAAVQPQYSlldRSPMEEELLDWAEENGLPLLAYSPLARG------------------PAQLALAWLLSQPFvtVPIV 219
|
250
....*....|..
gi 697052078 221 SSTKRENLASNL 232
Cdd:cd06660 220 GARSPEQLEENL 231
|
|
| AKR_BaDH-like |
cd19129 |
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ... |
2-236 |
3.87e-45 |
|
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.
Pssm-ID: 381355 [Multi-domain] Cd Length: 295 Bit Score: 153.77 E-value: 3.87e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 2 TLPAFGLGTFrLKDDVVIAS-VKTALELGYRAVDTAQIYENEAAVGQALEE----SGVPRNELFITTKIWIENLSKDKLI 76
Cdd:cd19129 5 AIPALGFGTL-IPDPSATRNaVKAALEAGFRHFDCAERYRNEAEVGEAMQEvfkaGKIRREDLFVTTKLWNTNHRPERVK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 77 PSLKESLKKLRTDYVDLTLIHWP---------SPNDA---------VSVEEFMQALLEAKKQGLTREIGISNFTIPLMeK 138
Cdd:cd19129 84 PAFEASLKRLQLDYLDLYLIHTPfafqpgdeqDPRDAngnviyddgVTLLDTWRAMERLVDEGRCKAIGLSDVSLEKL-R 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 139 AIAAVGAENIATNQIELSPYLQNRKVVDWAKQNGIHITSYMTLAYG---KALKDEVITRIAEKHNATAAQVILAWAMGEG 215
Cdd:cd19129 163 EIFEAARIKPAVVQVESHPYLPEWELLDFCKNHGIVLQAFAPLGHGmepKLLEDPVITAIARRVNKTPAQVLLAWAIQRG 242
|
250 260
....*....|....*....|....*
gi 697052078 216 YAVIPSSTK----RENLASNLLAAD 236
Cdd:cd19129 243 TALLTTSKTpsriRENFDISTLPED 267
|
|
| AKR_AKR1D1-3 |
cd19109 |
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ... |
2-257 |
1.38e-43 |
|
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.
Pssm-ID: 381335 [Multi-domain] Cd Length: 308 Bit Score: 149.95 E-value: 1.38e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 2 TLPAFGLGTF----RLKDDVVIASVKTALELGYRAVDTAQIYENEAAVGQALEES----GVPRNELFITTKIWIENLSKD 73
Cdd:cd19109 3 SIPIIGLGTYsepkTTPKGACAEAVKVAIDTGYRHIDGAYIYQNEHEVGQAIREKiaegKVKREDIFYCGKLWNTCHPPE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 74 KLIPSLKESLKKLRTDYVDLTLIHWP---SPNDAV--------------SVEEFMQALLEAKKQGLTREIGISNFTIPLM 136
Cdd:cd19109 83 LVRPTLERTLKVLQLDYVDLYIIEMPmafKPGDEIyprdengkwlyhktNLCATWEALEACKDAGLVKSIGVSNFNRRQL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 137 EKAIAAVGAE-NIATNQIELSPYLQNRKVVDWAKQNGIHITSYMTLAYGKA-----------LKDEVITRIAEKHNATAA 204
Cdd:cd19109 163 ELILNKPGLKhKPVSNQVECHPYFTQPKLLEFCQQHDIVIVAYSPLGTCRDpiwvnvsspplLEDPLLNSIGKKYNKTAA 242
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 697052078 205 QVILAWAMGEGYAVIPSSTKRENLASNLLAADLHLDADDKKAIAALECNDRLV 257
Cdd:cd19109 243 QVVLRFNIQRGVVVIPKSFNPERIKENFQIFDFSLTEEEMKDIEALNKNVRYV 295
|
|
| AKR_AKR1E1-2 |
cd19110 |
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ... |
3-256 |
4.90e-43 |
|
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.
Pssm-ID: 381336 [Multi-domain] Cd Length: 301 Bit Score: 148.18 E-value: 4.90e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 3 LPAFGLGTFRLKDDVVIASVKTALELGYRAVDTAQIYENEAAVG----QALEESGVPRNELFITTKIWIENLSKDKLIPS 78
Cdd:cd19110 4 IPAVGLGTWKASPGEVTEAVKVAIDAGYRHFDCAYLYHNESEVGagirEKIKEGVVRREDLFIVSKLWCTCHKKSLVKTA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 79 LKESLKKLRTDYVDLTLIHWP--------------------SPNDAVSVEEFMQALLeakKQGLTREIGISNFTIPLMEK 138
Cdd:cd19110 84 CTRSLKALKLNYLDLYLIHWPmgfkpgepdlpldrsgmvipSDTDFLDTWEAMEDLV---IEGLVKNIGVSNFNHEQLER 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 139 AIAAVGAE-NIATNQIELSPYLQNRKVVDWAKQNGIHITSYMTLAyGKA-----LKDEVITRIAEKHNATAAQVILAWAM 212
Cdd:cd19110 161 LLNKPGLRvKPVTNQIECHPYLTQKKLISFCQSRNVSVTAYRPLG-GSCegvdlIDDPVIQRIAKKHGKSPAQILIRFQI 239
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 697052078 213 GEGYAVIPSSTKRENLASNLLAADLHLDADDKKAIAALECNDRL 256
Cdd:cd19110 240 QRNVIVIPKSVTPSRIKENIQVFDFELTEHDMDNLLSLDRNLRL 283
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
1-247 |
2.24e-42 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 146.52 E-value: 2.24e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 1 MTLPAFGLGTF--------RLKDDVVIASVKTALELGYRAVDTAQIYEN---EAAVGQALEESgvpRNELFITTK---IW 66
Cdd:cd19084 2 LKVSRIGLGTWaiggtwwgEVDDQESIEAIKAAIDLGINFFDTAPVYGFghsEEILGKALKGR---RDDVVIATKcglRW 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 67 IE------NLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPNdaVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAI 140
Cdd:cd19084 79 DGgkgvtkDLSPESIRKEVEQSLRRLQTDYIDLYQIHWPDPN--TPIEETAEALEKLKKEGKIRYIGVSNFSVEQLEEAR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 141 AAVgaeNIATNQIELSPYLQN--RKVVDWAKQNGIHITSYMTLAYG------------------------------KALK 188
Cdd:cd19084 157 KYG---PIVSLQPPYSMLEREieEELLPYCRENGIGVLPYGPLAQGlltgkykkeptfppddrrsrfpffrgenfeKNLE 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 697052078 189 D-EVITRIAEKHNATAAQVILAWAMG--EGYAVIPSSTKRENLASNLLAADLHLDADDKKAI 247
Cdd:cd19084 234 IvDKLKEIAEKYGKSLAQLAIAWTLAqpGVTSAIVGAKNPEQLEENAGALDWELTEEELKEI 295
|
|
| AKR_AKR1C1-35 |
cd19108 |
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ... |
3-255 |
2.42e-42 |
|
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.
Pssm-ID: 381334 [Multi-domain] Cd Length: 303 Bit Score: 146.61 E-value: 2.42e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 3 LPAFGLGTFR----LKDDVVIAsVKTALELGYRAVDTAQIYENEAAVGQAL----EESGVPRNELFITTKIWIENLSKDK 74
Cdd:cd19108 11 IPVLGFGTYApeevPKSKALEA-TKLAIDAGFRHIDSAYLYQNEEEVGQAIrskiADGTVKREDIFYTSKLWCTFHRPEL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 75 LIPSLKESLKKLRTDYVDLTLIHWPSP-----------------NDAVSVEEFMQALLEAKKQGLTREIGISNFTIPLME 137
Cdd:cd19108 90 VRPALEKSLKKLQLDYVDLYLIHFPVAlkpgeelfpkdengkliFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNRRQLE 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 138 KAIAAVGAENIAT-NQIELSPYLQNRKVVDWAKQNGIHITSYMTLAYGKA-----------LKDEVITRIAEKHNATAAQ 205
Cdd:cd19108 170 MILNKPGLKYKPVcNQVECHPYLNQSKLLDFCKSKDIVLVAYSALGSQRDkewvdqnspvlLEDPVLCALAKKHKRTPAL 249
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 697052078 206 VILAWAMGEGYAVIPSSTKRENLASNLLAADLHLDADDKKAIAALECNDR 255
Cdd:cd19108 250 IALRYQLQRGVVVLAKSFNEKRIKENLQVFEFQLTSEDMKALDGLNRNLR 299
|
|
| AKR_AKR3E1 |
cd19122 |
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ... |
2-242 |
1.40e-40 |
|
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.
Pssm-ID: 381348 [Multi-domain] Cd Length: 291 Bit Score: 141.61 E-value: 1.40e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 2 TLPAFGLGTFRLK--DDVVIASVKTALELGYRAVDTAQIYENEAAVGQAL-----EESGVPRNELFITTKIWIENLSKDK 74
Cdd:cd19122 8 KIPAVGFGTFANEgaKGETYAAVTKALDVGYRHLDCAWFYLNEDEVGDAVrdflkENPSVKREDLFICTKVWNHLHEPED 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 75 LIPSLKESLKKLRTDYVDLTLIHWP---SPNDAVSV------------------EEFMQALLEAKKQGLTREIGISNFTI 133
Cdd:cd19122 88 VKWSIDNSLKNLKLDYIDLFLVHWPiaaEKNDQRSPklgpdgkyvilkdltenpEPTWRAMEEIYESGKAKAIGVSNWTI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 134 PLMEKAIAAVGAENiATNQIELSPYLQNRKVVDWAKQNGIHITSYMTL-------AYGKALKD-EVITRIAEKHNATAAQ 205
Cdd:cd19122 168 PGLKKLLSFAKVKP-HVNQIEIHPFLPNEELVDYCFSNDILPEAYSPLgsqnqvpSTGERVSEnPTLNEVAEKGGYSLAQ 246
|
250 260 270
....*....|....*....|....*....|....*..
gi 697052078 206 VILAWAMGEGYAVIPSSTKRENLASNLLAADLHlDAD 242
Cdd:cd19122 247 VLIAWGLRRGYVVLPKSSTPSRIESNFKSIELS-DED 282
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
1-243 |
2.09e-40 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 141.15 E-value: 2.09e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 1 MTLPAFGLGTFRLKDDV-----VIASVKTALELGYRAVDTAQIY---ENEAAVGQALEESGVPRNELFITTKIWIE---- 68
Cdd:cd19092 4 LEVSRLVLGCMRLADWGesaeeLLSLIEAALELGITTFDHADIYgggKCEELFGEALALNPGLREKIEIQTKCGIRlgdd 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 69 ---------NLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPndAVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEkA 139
Cdd:cd19092 84 prpgrikhyDTSKEHILASVEGSLKRLGTDYLDLLLLHRPDP--LMDPEEVAEAFDELVKSGKVRYFGVSNFTPSQIE-L 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 140 IAAVGAENIATNQIELSPY---LQNRKVVDWAKQNGIHITSYMTLAYGKALKD---------EVITRIAEKHNATAAQVI 207
Cdd:cd19092 161 LQSYLDQPLVTNQIELSLLhteAIDDGTLDYCQLLDITPMAWSPLGGGRLFGGfderfqrlrAALEELAEEYGVTIEAIA 240
|
250 260 270
....*....|....*....|....*....|....*...
gi 697052078 208 LAWAMGEGYAVIP--SSTKRENLASNLLAADLHLDADD 243
Cdd:cd19092 241 LAWLLRHPARIQPilGTTNPERIRSAVKALDIELTREE 278
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
3-251 |
4.44e-40 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 140.44 E-value: 4.44e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 3 LPAFGLGTF-----------RLKDDVVIASVKTALELGYRAVDTAQIY---ENEAAVGQALEESGvPRNELFITTKIWIE 68
Cdd:cd19093 2 VSPLGLGTWqwgdrlwwgygEYGDEDLQAAFDAALEAGVNLFDTAEVYgtgRSERLLGRFLKELG-DRDEVVIATKFAPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 69 --NLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPNDAvSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIAAVGAE 146
Cdd:cd19093 81 pwRLTRRSVVKALKASLERLGLDSIDLYQLHWPGPWYS-QIEALMDGLADAVEEGLVRAVGVSNYSADQLRRAHKALKER 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 147 NI--ATNQIE---LSPYLQNRKVVDWAKQNGIHITSYMTLAYG----------------------KALKD-----EVITR 194
Cdd:cd19093 160 GVplASNQVEyslLYRDPEQNGLLPACDELGITLIAYSPLAQGlltgkyspenpppggrrrlfgrKNLEKvqpllDALEE 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 697052078 195 IAEKHNATAAQVILAWAMGEGYAVIPSSTKRENLASNLLAADLHLDADDkkaIAALE 251
Cdd:cd19093 240 IAEKYGKTPAQVALNWLIAKGVVPIPGAKNAEQAEENAGALGWRLSEEE---VAELD 293
|
|
| YdhF |
COG4989 |
Predicted oxidoreductase YdhF [General function prediction only]; |
8-243 |
1.16e-39 |
|
Predicted oxidoreductase YdhF [General function prediction only];
Pssm-ID: 444013 [Multi-domain] Cd Length: 299 Bit Score: 139.52 E-value: 1.16e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 8 LGTFRLKD-----DVVIASVKTALELGYRAVDTAQIY---ENEAAVGQALEESGVPRNELFITTKIWIE----------- 68
Cdd:COG4989 18 LGCMRLGEwdlspAEAAALIEAALELGITTFDHADIYggyTCEALFGEALKLSPSLREKIELQTKCGIRlpseardnrvk 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 69 --NLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPndAVSVEEFMQALLEAKKQGLTREIGISNFT---IPLMEKAIaav 143
Cdd:COG4989 98 hyDTSKEHIIASVEGSLRRLGTDYLDLLLLHRPDP--LMDPEEVAEAFDELKASGKVRHFGVSNFTpsqFELLQSAL--- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 144 gAENIATNQIELSPY----LQNRkVVDWAKQNGIHITSYMTLAYGKALKD---------EVITRIAEKHNATAAQVILAW 210
Cdd:COG4989 173 -DQPLVTNQIELSLLhtdaFDDG-TLDYCQLNGITPMAWSPLAGGRLFGGfdeqfprlrAALDELAEKYGVSPEAIALAW 250
|
250 260 270
....*....|....*....|....*....|....*
gi 697052078 211 AMGEGYAVIP--SSTKRENLASNLLAADLHLDADD 243
Cdd:COG4989 251 LLRHPAGIQPviGTTNPERIKAAAAALDIELTREE 285
|
|
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
3-240 |
6.37e-36 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 128.49 E-value: 6.37e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 3 LPAFGLGTFRL----------KDDVVIASVKTALELGYRAVDTAQIY---ENEAAVGQALEesgvPRNE-LFITTKI--- 65
Cdd:cd19088 1 VSRLGYGAMRLtgpgiwgppaDREEAIAVLRRALELGVNFIDTADSYgpdVNERLIAEALH----PYPDdVVIATKGglv 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 66 ------WIENLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPNdaVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKA 139
Cdd:cd19088 77 rtgpgwWGPDGSPEYLRQAVEASLRRLGLDRIDLYQLHRIDPK--VPFEEQLGALAELQDEGLIRHIGLSNVTVAQIEEA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 140 IAAVGaenIATNQIELSPYlqNRK---VVDWAKQNGIHITSYMTLAYGKALKDEVITR-IAEKHNATAAQVILAW--AMG 213
Cdd:cd19088 155 RAIVR---IVSVQNRYNLA--NRDdegVLDYCEAAGIAFIPWFPLGGGDLAQPGGLLAeVAARLGATPAQVALAWllARS 229
|
250 260
....*....|....*....|....*..
gi 697052078 214 EGYAVIPSSTKRENLASNLLAADLHLD 240
Cdd:cd19088 230 PVMLPIPGTSSVEHLEENLAAAGLRLS 256
|
|
| AKR_unchar |
cd19102 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
15-250 |
1.23e-34 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 126.25 E-value: 1.23e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 15 DDVVIASVKTALELGYRAVDTAQIY---ENEAAVGQALEESgvpRNELFITTK---IWIEN------LSKDKLIPSLKES 82
Cdd:cd19102 25 DRDSIAAIRAALDLGINWIDTAAVYglgHSEEVVGRALKGL---RDRPIVATKcglLWDEEgrirrsLKPASIRAECEAS 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 83 LKKLRTDYVDLTLIHWPSPNDavSVEEFMQALLEAKKQGLTREIGISNFTIPLMeKAIAAVGAenIATNQIELSpyLQNR 162
Cdd:cd19102 102 LRRLGVDVIDLYQIHWPDPDE--PIEEAWGALAELKEEGKVRAIGVSNFSVDQM-KRCQAIHP--IASLQPPYS--LLRR 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 163 ----KVVDWAKQNGIHITSYMTLAYG---------KALKD------------------------EVITRIAEKHNATAAQ 205
Cdd:cd19102 175 gieaEILPFCAEHGIGVIVYSPMQSGlltgkmtpeRVASLpaddwrrrspffqepnlarnlalvDALRPIAERHGRTVAQ 254
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 697052078 206 VILAWAMG--EGYAVIPSSTKRENLASNLLAADLHLDADDKKAIAAL 250
Cdd:cd19102 255 LAIAWVLRrpEVTSAIVGARRPDQIDETVGAADLRLTPEELAEIEAL 301
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
1-247 |
6.16e-33 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 121.94 E-value: 6.16e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 1 MTLPAFGLGTFRL-------KDDVVIASVKTALELGYRAVDTAQIY---ENEAAVGQALEEsgvPRNELFITTKIWIENL 70
Cdd:cd19076 10 LEVSALGLGCMGMsafygpaDEEESIATLHRALELGVTFLDTADMYgpgTNEELLGKALKD---RRDEVVIATKFGIVRD 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 71 SKDKLIP----------SLKESLKKLRTDYVDLTLIHWPSPNdaVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKA- 139
Cdd:cd19076 87 PGSGFRGvdgrpeyvraACEASLKRLGTDVIDLYYQHRVDPN--VPIEETVGAMAELVEEGKVRYIGLSEASADTIRRAh 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 140 ----IAAVgaeniatnQIELSPYLQN--RKVVDWAKQNGIHITSYMTLAYG------KALKD------------------ 189
Cdd:cd19076 165 avhpITAV--------QSEYSLWTRDieDEVLPTCRELGIGFVAYSPLGRGfltgaiKSPEDlpeddfrrnnprfqgenf 236
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 697052078 190 -------EVITRIAEKHNATAAQVILAWAMGEGYAV--IPSSTKRENLASNLLAADLHLDADDKKAI 247
Cdd:cd19076 237 dknlklvEKLEAIAAEKGCTPAQLALAWVLAQGDDIvpIPGTKRIKYLEENVGALDVVLTPEELAEI 303
|
|
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
1-249 |
7.50e-32 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 119.30 E-value: 7.50e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 1 MTLPAFGLGTF---------RLKDDVVIASVKTALELGYRAVDTAQIYEN---EAAVGQALEESgvpRNELFITTK---I 65
Cdd:cd19149 9 IEASVIGLGTWaigggpwwgGSDDNESIRTIHAALDLGINLIDTAPAYGFghsEEIVGKAIKGR---RDKVVLATKcglR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 66 WIE----------------NLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPNdaVSVEEFMQALLEAKKQGLTREIGIS 129
Cdd:cd19149 86 WDReggsfffvrdgvtvykNLSPESIREEVEQSLKRLGTDYIDLYQTHWQDVE--TPIEETMEALEELKRQGKIRAIGAS 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 130 NFTIplmEKAIAAVGAENIATNQIELSpyLQNRKV----VDWAKQNGIHITSYMTLAYG----KALKD------------ 189
Cdd:cd19149 164 NVSV---EQIKEYVKAGQLDIIQEKYS--MLDRGIekelLPYCKKNNIAFQAYSPLEQGlltgKITPDrefdagdarsgi 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 697052078 190 ---------------EVITRIAEKHNATAAQVILAWAMGEG--YAVIPSSTKRENLASNLLAADLHLDADDKKAIAA 249
Cdd:cd19149 239 pwfspenrekvlallEKWKPLCEKYGCTLAQLVIAWTLAQPgiTSALCGARKPEQAEENAKAGDIRLSAEDIATMRS 315
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
13-250 |
7.41e-31 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 116.36 E-value: 7.41e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 13 LKDDVVIASVKTALELGYRAVDTAQIY---ENEAAVGQALEESGvpRNELFITTK---------IWIENlSKDKLIPSLK 80
Cdd:cd19083 30 LDEEEGKDLVREALDNGVNLLDTAFIYglgRSEELVGEVLKEYN--RNEVVIATKgahkfggdgSVLNN-SPEFLRSAVE 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 81 ESLKKLRTDYVDLTLIHWPSPNdaVSVEEFMQALLEAKKQGLTREIGISNFTIPLMeKAIAAVGAENIATNQIELSPYLQ 160
Cdd:cd19083 107 KSLKRLNTDYIDLYYIHFPDGE--TPKAEAVGALQELKDEGKIRAIGVSNFSLEQL-KEANKDGYVDVLQGEYNLLQREA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 161 NRKVVDWAKQNGIHITSYMTLAY----GKALKD---------------------------EVITRIAEKHNATAAQVILA 209
Cdd:cd19083 184 EEDILPYCVENNISFIPYFPLASgllaGKYTKDtkfpdndlrndkplfkgerfsenldkvDKLKSIADEKGVTVAHLALA 263
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 697052078 210 WAMGEGY--AVIPSSTKRENLASNLLAADLHLDADDKKAIAAL 250
Cdd:cd19083 264 WYLTRPAidVVIPGAKRAEQVIDNLKALDVTLTEEEIAFIDAL 306
|
|
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
22-247 |
1.80e-29 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 113.06 E-value: 1.80e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 22 VKTALELGYRAVDTAQIYEN---EAAVGQALEESGvPRNELFITTKIWI--------ENLSKDKLIPSLKESLKKLRTDY 90
Cdd:cd19079 41 IKRALDLGINFFDTANVYSGgasEEILGRALKEFA-PRDEVVIATKVYFpmgdgpngRGLSRKHIMAEVDASLKRLGTDY 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 91 VDLTLIHWPSPNdaVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIaavgaeNIATNQiELSPY--LQN------- 161
Cdd:cd19079 120 IDLYQIHRWDYE--TPIEETLEALHDVVKSGKVRYIGASSMYAWQFAKAL------HLAEKN-GWTKFvsMQNhynllyr 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 162 ---RKVVDWAKQNGIHITSYMTLAYG--------------------KALKD-------EVITR---IAEKHNATAAQVIL 208
Cdd:cd19079 191 eeeREMIPLCEEEGIGVIPWSPLARGrlarpwgdtterrrsttdtaKLKYDyfteadkEIVDRveeVAKERGVSMAQVAL 270
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 697052078 209 AWAMGEGYAVIP--SSTKRENLASNLLAADLHLDADDKKAI 247
Cdd:cd19079 271 AWLLSKPGVTAPivGATKLEHLEDAVAALDIKLSEEEIKYL 311
|
|
| COG1453 |
COG1453 |
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only]; |
1-251 |
2.69e-29 |
|
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 113.38 E-value: 2.69e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 1 MTLPAFGLGTFRL--KD-DVVIASVKTALELGYRAVDTAQIYEN-EAAVGQALEEsgvPRNELFITTKI--WIENlsKDK 74
Cdd:COG1453 11 LEVSVLGFGGMRLprKDeEEAEALIRRAIDNGINYIDTARGYGDsEEFLGKALKG---PRDKVILATKLppWVRD--PED 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 75 LIPSLKESLKKLRTDYVDLTLIHwpSPNDAVSVE------EFMQALLEAKKQGLTREIGISNF-TIPLMEKAIAavgAEN 147
Cdd:COG1453 86 MRKDLEESLKRLQTDYIDLYLIH--GLNTEEDLEkvlkpgGALEALEKAKAEGKIRHIGFSTHgSLEVIKEAID---TGD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 148 IATNQIELSPYLQN----RKVVDWAKQNGIHITSyM-TLAYGK-ALKDEVITRIAEKHNATAAQVIL-AWAMGEGYAVIP 220
Cdd:COG1453 161 FDFVQLQYNYLDQDnqagEEALEAAAEKGIGVII-MkPLKGGRlANPPEKLVELLCPPLSPAEWALRfLLSHPEVTTVLS 239
|
250 260 270
....*....|....*....|....*....|...
gi 697052078 221 SSTKRENLASNLLAADLH--LDADDKKAIAALE 251
Cdd:COG1453 240 GMSTPEQLDENLKTADNLepLTEEELAILERLA 272
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
27-247 |
3.05e-29 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 112.31 E-value: 3.05e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 27 ELGYRAVDTAQIY----------ENEAAVGQALEESGvPRNELFITTKI--WI----ENLSKDKLIPSLKESLKKLRTDY 90
Cdd:cd19081 37 DAGGNFIDTADVYsawvpgnaggESETIIGRWLKSRG-KRDRVVIATKVgfPMgpngPGLSRKHIRRAVEASLRRLQTDY 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 91 VDLTLIHWPSPndAVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIAAVGAENiatnqieLSPY--LQ------NR 162
Cdd:cd19081 116 IDLYQAHWDDP--ATPLEETLGALNDLIRQGKVRYIGASNYSAWRLQEALELSRQHG-------LPRYvsLQpeynlvDR 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 163 KVVDW-----AKQNGIHITSYMTLAYG-----------------------KALKD------EVITRIAEKHNATAAQVIL 208
Cdd:cd19081 187 ESFEGellplCREEGIGVIPYSPLAGGfltgkyrseadlpgstrrgeaakRYLNErglrilDALDEVAAEHGATPAQVAL 266
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 697052078 209 AWAMGEGY--AVIPSSTKRENLASNLLAADLHLDADDKKAI 247
Cdd:cd19081 267 AWLLARPGvtAPIAGARTVEQLEDLLAAAGLRLTDEEVARL 307
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
4-234 |
3.91e-29 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 110.79 E-value: 3.91e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 4 PAFGLGTFRLKDDVVIASVK-------TALELGYRAVDTAQIYEN-EAAVGQALeeSGVPRNELFITTKIWIEN------ 69
Cdd:cd19095 1 SVLGLGTSGIGRVWGVPSEAeaarllnTALDLGINLIDTAPAYGRsEERLGRAL--AGLRRDDLFIATKVGTHGeggrdr 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 70 --LSKDKLIPSLKESLKKLRTDYVDLTLIHwpSPNDAVSVEEFMQALLEAKKQGLTREIGISNFTiPLMEKAIAavgAEN 147
Cdd:cd19095 79 kdFSPAAIRASIERSLRRLGTDYIDLLQLH--GPSDDELTGEVLETLEDLKAAGKVRYIGVSGDG-EELEAAIA---SGV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 148 IATNQIELSPYLQ-NRKVVDWAKQNGIHITSYMTLAYGKALKDE-----------VITRIAEKHNATAAQVILAWAMGEG 215
Cdd:cd19095 153 FDVVQLPYNVLDReEEELLPLAAEAGLGVIVNRPLANGRLRRRVrrrplyadyarRPEFAAEIGGATWAQAALRFVLSHP 232
|
250 260
....*....|....*....|.
gi 697052078 216 Y--AVIPSSTKRENLASNLLA 234
Cdd:cd19095 233 GvsSAIVGTTNPEHLEENLAA 253
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
1-235 |
5.89e-29 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 109.98 E-value: 5.89e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 1 MTLPAFGLGTFRLkDDVVIASVKTALELGYRAVDTAQIY---ENEAAVGQALeeSGVPRNELFITTKIWIENLSKDK--L 75
Cdd:cd19105 11 LKVSRLGFGGGGL-PRESPELLRRALDLGINYFDTAEGYgngNSEEIIGEAL--KGLRRDKVFLATKASPRLDKKDKaeL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 76 IPSLKESLKKLRTDYVDLTLIHWPSPND-AVSVEEFMQALLEAKKQGLTREIGIS--NFTIPLMEKAI------AAVGAE 146
Cdd:cd19105 88 LKSVEESLKRLQTDYIDIYQLHGVDTPEeRLLNEELLEALEKLKKEGKVRFIGFSthDNMAEVLQAAIesgwfdVIMVAY 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 147 NIATNQIELspylqnRKVVDWAKQNGIHITSYMTLAYGKALKDEviTRIAEKHNATAAQVILAWAMGEGY--AVIPSSTK 224
Cdd:cd19105 168 NFLNQPAEL------EEALAAAAEKGIGVVAMKTLAGGYLQPAL--LSVLKAKGFSLPQAALKWVLSNPRvdTVVPGMRN 239
|
250
....*....|.
gi 697052078 225 RENLASNLLAA 235
Cdd:cd19105 240 FAELEENLAAA 250
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
24-236 |
5.39e-28 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 108.41 E-value: 5.39e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 24 TALELGYRAVDTAQIY-------ENEAAVGQALEESGVpRNELFITTK--------IWIENLSKDKLIPSLKESLKKLRT 88
Cdd:cd19082 25 AFVELGGNFIDTARVYgdwvergASERVIGEWLKSRGN-RDKVVIATKgghpdledMSRSRLSPEDIRADLEESLERLGT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 89 DYVDLTLIHWPSPNdaVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIA---AVGAENIATNQIELS------PYL 159
Cdd:cd19082 104 DYIDLYFLHRDDPS--VPVGEIVDTLNELVRAGKIRAFGASNWSTERIAEANAyakAHGLPGFAASSPQWSlarpnePPW 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 160 QNRKVV-------DWAKQNGIHITSYMTLAYG---KALKDEVIT---------------------RIAEKHNATAAQVIL 208
Cdd:cd19082 182 PGPTLVamdeemrAWHEENQLPVFAYSSQARGffsKRAAGGAEDdselrrvyyseenferlerakELAEEKGVSPTQIAL 261
|
250 260 270
....*....|....*....|....*....|
gi 697052078 209 AWAMGEGYAVIP--SSTKRENLASNLLAAD 236
Cdd:cd19082 262 AYVLNQPFPTVPiiGPRTPEQLRDSLAAAD 291
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
2-247 |
8.13e-28 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 108.68 E-value: 8.13e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 2 TLPAFGLGTF--------RLKDDVVIASVKTALELGYRAVDTAQIY-ENEAAVGQALEESGVPRNELFITTKIWIE---- 68
Cdd:cd19144 12 SVPALGFGAMglsafygpPKPDEERFAVLDAAFELGCTFWDTADIYgDSEELIGRWFKQNPGKREKIFLATKFGIEknve 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 69 ------NLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPNdaVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIAa 142
Cdd:cd19144 92 tgeysvDGSPEYVKKACETSLKRLGVDYIDLYYQHRVDGK--TPIEKTVAAMAELVQEGKIKHIGLSECSAETLRRAHA- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 143 vgAENIATNQIELSPYL-----QNRKVVDWAKQNGIHITSYMTLAYG--------------------------------K 185
Cdd:cd19144 169 --VHPIAAVQIEYSPFSldierPEIGVLDTCRELGVAIVAYSPLGRGfltgairspddfeegdfrrmaprfqaenfpknL 246
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 697052078 186 ALKDEvITRIAEKHNATAAQVILAW--AMGEGYAVIPSSTKRENLASNLLAADLHLDADDKKAI 247
Cdd:cd19144 247 ELVDK-IKAIAKKKNVTAGQLTLAWllAQGDDIIPIPGTTKLKRLEENLGALKVKLTEEEEKEI 309
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
7-242 |
1.02e-26 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 105.37 E-value: 1.02e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 7 GLGTF-----RLKDDVVIASVKTALELGYRAVDTAQIYEN---EAAVGQALeeSGVPRNELFITTKI-WI-------ENL 70
Cdd:cd19074 8 SLGTWltfggQVDDEDAKACVRKAYDLGINFFDTADVYAAgqaEEVLGKAL--KGWPRESYVISTKVfWPtgpgpndRGL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 71 SKDKLIPSLKESLKKLRTDYVDLTLIHWPSPNdaVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKA---IAAVGAEN 147
Cdd:cd19074 86 SRKHIFESIHASLKRLQLDYVDIYYCHRYDPE--TPLEETVRAMDDLIRQGKILYWGTSEWSAEQIAEAhdlARQFGLIP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 148 IATNQIELSpYLQNRK---VVDWAKQNGIHITSYMTLAYG-----------------------KALKDEVITR------- 194
Cdd:cd19074 164 PVVEQPQYN-MLWREIeeeVIPLCEKNGIGLVVWSPLAQGlltgkyrdgipppsrsratdednRDKKRRLLTDenlekvk 242
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 697052078 195 ----IAEKHNATAAQVILAWAMG--EGYAVIPSSTKRENLASNLLAADLHLDAD 242
Cdd:cd19074 243 klkpIADELGLTLAQLALAWCLRnpAVSSAIIGASRPEQLEENVKASGVKLSPE 296
|
|
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
4-140 |
4.95e-26 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 103.02 E-value: 4.95e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 4 PAFGLGTFRL-------KDDVVIASVKTALELGYRAVDTAQIY-ENEAAVGQALEEsgVPRNELFITTKI-----WIENL 70
Cdd:cd19090 1 SALGLGTAGLggvfggvDDDEAVATIRAALDLGINYIDTAPAYgDSEERLGLALAE--LPREPLVLSTKVgrlpeDTADY 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 697052078 71 SKDKLIPSLKESLKKLRTDYVDLTLIH---WPSPNDAVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAI 140
Cdd:cd19090 79 SADRVRRSVEESLERLGRDRIDLLMIHdpeRVPWVDILAPGGALEALLELKEEGLIKHIGLGGGPPDLLRRAI 151
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
19-184 |
4.73e-25 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 100.84 E-value: 4.73e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 19 IASVKTALELGYRAVDTAQIY---ENEAAVGQALEESGvPRNELFITTKI---WIE------NLSKDKLIPSLKESLKKL 86
Cdd:cd19148 28 IETIHKALDLGINLIDTAPVYgfgLSEEIVGKALKEYG-KRDRVVIATKVgleWDEggevvrNSSPARIRKEVEDSLRRL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 87 RTDYVDLTLIHWPSPndAVSVEEFMQALLEAKKQGLTREIGISNFTIPLME--KAIAAvgaenIATNQielSPY-----L 159
Cdd:cd19148 107 QTDYIDLYQVHWPDP--LVPIEETAEALKELLDEGKIRAIGVSNFSPEQMEtfRKVAP-----LHTVQ---PPYnlferE 176
|
170 180
....*....|....*....|....*
gi 697052078 160 QNRKVVDWAKQNGIhitsyMTLAYG 184
Cdd:cd19148 177 IEKDVLPYARKHNI-----VTLAYG 196
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
22-251 |
5.48e-25 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 101.15 E-value: 5.48e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 22 VKTALELGYRAVDTAQIY---ENEAAVGQALEESgvpRNELFITTKI--WIEN------LSKDKLIPSLKESLKKLRTDY 90
Cdd:cd19091 45 VDIALDAGINFFDTADVYsegESEEILGKALKGR---RDDVLIATKVrgRMGEgpndvgLSRHHIIRAVEASLKRLGTDY 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 91 VDLTLIHWPSPndAVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIA---AVGAENIATNQIELSpyLQNR----K 163
Cdd:cd19091 122 IDLYQLHGFDA--LTPLEETLRALDDLVRQGKVRYIGVSNFSAWQIMKALGiseRRGLARFVALQAYYS--LLGRdlehE 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 164 VVDWAKQNGIHITSYMTLAY----GKALKD----------------------------EVITRIAEKHNATAAQVILAWA 211
Cdd:cd19091 198 LMPLALDQGVGLLVWSPLAGgllsGKYRRGqpapegsrlrrtgfdfppvdrergydvvDALREIAKETGATPAQVALAWL 277
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 697052078 212 MGEGY--AVIPSSTKRENLASNLLAADLHLDADDkkaIAALE 251
Cdd:cd19091 278 LSRPTvsSVIIGARNEEQLEDNLGAAGLSLTPEE---IARLD 316
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
7-184 |
8.19e-25 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 98.70 E-value: 8.19e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 7 GLGTFRL--------KDDVVIASVKTALELGYRAVDTAQIY---ENEAAVGQALEEsgvPRNELFITTKI---------W 66
Cdd:cd19086 7 GFGTWGLggdwwgdvDDAEAIRALRAALDLGINFFDTADVYgdgHSERLLGKALKG---RRDKVVIATKFgnrfdggpeR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 67 IENLSKDKLIPSLKESLKKLRTDYVDLTLIHWPsPNDAVSVEEFMQALLEAKKQGLTREIGISnfTIPLmEKAIAAVGAE 146
Cdd:cd19086 84 PQDFSPEYIREAVEASLKRLGTDYIDLYQLHNP-PDEVLDNDELFEALEKLKQEGKIRAYGVS--VGDP-EEALAALRRG 159
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 697052078 147 NIATNQIELSPYLQN--RKVVDWAKQNGIHITSYMTLAYG 184
Cdd:cd19086 160 GIDVVQVIYNLLDQRpeEELFPLAEEHGVGVIARVPLASG 199
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
1-140 |
9.44e-25 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 98.71 E-value: 9.44e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 1 MTLPAFGLGT---FRLKDDVVIASVKTALELGYRAVDTAQIYEN-EAAVGQALEEsgvPRNELFITTKIWieNLSKDKLI 76
Cdd:cd19100 9 LKVSRLGFGGgplGRLSQEEAAAIIRRALDLGINYFDTAPSYGDsEEKIGKALKG---RRDKVFLATKTG--ARDYEGAK 83
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 697052078 77 PSLKESLKKLRTDYVDLTLIHWPS----PNDAVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAI 140
Cdd:cd19100 84 RDLERSLKRLGTDYIDLYQLHAVDteedLDQVFGPGGALEALLEAKEEGKIRFIGISGHSPEVLLRAL 151
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
26-236 |
8.18e-24 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 97.40 E-value: 8.18e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 26 LELGYRAVDTAQIY----------ENEAAVGQALEESGVpRNELFITTK------------IWIENLSKDKLIPSLKESL 83
Cdd:cd19752 27 VAAGGNFLDTANNYafwteggvggESERLIGRWLKDRGN-RDDVVIATKvgagprdpdggpESPEGLSAETIEQEIDKSL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 84 KKLRTDYVDLTLIHWPSPNdaVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAiaavgaENIATNQ-------IELS 156
Cdd:cd19752 106 RRLGTDYIDLYYAHVDDRD--TPLEETLEAFNELVKAGKVRAIGASNFAAWRLERA------RQIARQQgwaefsaIQQR 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 157 -PYLQNR-------------KVVDWAKQNG-IHITSYMTLAYG------KALKD-----------EVITRIAEKHNATAA 204
Cdd:cd19752 178 hSYLRPRpgadfgvqrivtdELLDYASSRPdLTLLAYSPLLSGaytrpdRPLPEqydgpdsdarlAVLEEVAGELGATPN 257
|
250 260 270
....*....|....*....|....*....|....
gi 697052078 205 QVILAWAMGEGYAVIP--SSTKRENLASNLLAAD 236
Cdd:cd19752 258 QVVLAWLLHRTPAIIPllGASTVEQLEENLAALD 291
|
|
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
19-247 |
8.68e-24 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 97.30 E-value: 8.68e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 19 IASVKTALELGYRAVDTAQIY---ENEAAVGQALEEsgvPRNELFITTK--IWIENLSKDKLIP---------SLKESLK 84
Cdd:cd19078 28 IELIRKAVELGITFFDTAEVYgpyTNEELVGEALKP---FRDQVVIATKfgFKIDGGKPGPLGLdsrpehirkAVEGSLK 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 85 KLRTDYVDLTLIHWPSPNdaVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKA-----IAAVGAE-NIATNQIE--LS 156
Cdd:cd19078 105 RLQTDYIDLYYQHRVDPN--VPIEEVAGTMKELIKEGKIRHWGLSEAGVETIRRAhavcpVTAVQSEySMMWREPEkeVL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 157 PYLQnrkvvdwakQNGIHITSYMTLAYG--------------------------KALKD-----EVITRIAEKHNATAAQ 205
Cdd:cd19078 183 PTLE---------ELGIGFVPFSPLGKGfltgkidentkfdegddraslprftpEALEAnqalvDLLKEFAEEKGATPAQ 253
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 697052078 206 VILAWAMGEG-YAV-IPSSTKRENLASNLLAADLHLDADDKKAI 247
Cdd:cd19078 254 IALAWLLAKKpWIVpIPGTTKLSRLEENIGAADIELTPEELREI 297
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
14-249 |
1.11e-23 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 97.28 E-value: 1.11e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 14 KDDVVIASVKTALELGYRAVDTAQIYEN-EAAVGQALEESG---------------VPRNELFITTKIWIENlskdklip 77
Cdd:cd19101 21 DEDAAVRAMAAYVDAGLTTFDCADIYGPaEELIGEFRKRLRrerdaaddvqihtkwVPDPGELTMTRAYVEA-------- 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 78 SLKESLKKLRTDYVDLTLIHWPSPNDAVSVEeFMQALLEAKKQGLTREIGISNFTIPLMEKAIAAvGAEnIATNQIELS- 156
Cdd:cd19101 93 AIDRSLKRLGVDRLDLVQFHWWDYSDPGYLD-AAKHLAELQEEGKIRHLGLTNFDTERLREILDA-GVP-IVSNQVQYSl 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 157 ----PylqNRKVVDWAKQNGIHITSYMTLAYG-------------------------KALKDE------------VITRI 195
Cdd:cd19101 170 ldrrP---ENGMAALCEDHGIKLLAYGTLAGGllsekylgvpeptgpaletrslqkyKLMIDEwggwdlfqellrTLKAI 246
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 697052078 196 AEKHNATAAQVILAWAM---GEGyAVIPSSTKRENLASNLLAADLHLDADDKKAIAA 249
Cdd:cd19101 247 ADKHGVSIANVAVRWVLdqpGVA-GVIVGARNSEHIDDNVRAFSFRLDDEDRAAIDA 302
|
|
| AKR_AKR8A1-2 |
cd19077 |
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ... |
6-247 |
2.74e-23 |
|
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 96.15 E-value: 2.74e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 6 FGLGTFRL-------KDDVVIASVKTALELGYRAVDTAQIY------ENEAAVGQALEESGVPRNELFITTKI-WIENL- 70
Cdd:cd19077 8 IGLGLMGLtwrpnptPDEEAFETMKAALDAGSNLWNGGEFYgppdphANLKLLARFFRKYPEYADKVVLSVKGgLDPDTl 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 71 ----SKDKLIPSLKESLKKLR-TDYVDltlIHWPSPND-AVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAiAAVg 144
Cdd:cd19077 88 rpdgSPEAVRKSIENILRALGgTKKID---IFEPARVDpNVPIEETIKALKELVKEGKIRGIGLSEVSAETIRRA-HAV- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 145 aENIATNQIELSPY----LQNrKVVDWAKQNGIHITSYMTLAYG------KALKD------------------------- 189
Cdd:cd19077 163 -HPIAAVEVEYSLFsreiEEN-GVLETCAELGIPIIAYSPLGRGlltgriKSLADipegdfrrhldrfngenfeknlklv 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 697052078 190 EVITRIAEKHNATAAQVILAWAMGEGYAV---IPSSTKRENLASNLLAADLHLDADDKKAI 247
Cdd:cd19077 241 DALQELAEKKGCTPAQLALAWILAQSGPKiipIPGSTTLERVEENLKAANVELTDEELKEI 301
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
5-250 |
1.00e-22 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 94.71 E-value: 1.00e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 5 AFGLGTF--RLKDDVVIASVKTALELGYRAVDTAQIY---ENEAAVGQALEEsgVPRNELFITTKI--WIENLSKDKLIP 77
Cdd:cd19103 19 AGGDQVFgnHLDEDTLKAVFDKAMAAGLNLWDTAAVYgmgASEKILGEFLKR--YPREDYIISTKFtpQIAGQSADPVAD 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 78 SLKESLKKLRTDYVDLTLIHWPSpndavSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIAAVGAENIATNQIELSP 157
Cdd:cd19103 97 MLEGSLARLGTDYIDIYWIHNPA-----DVERWTPELIPLLKSGKVKHVGVSNHNLAEIKRANEILAKAGVSLSAVQNHY 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 158 YLQNRK-----VVDWAKQNGIHITSYMTL-------AYGKA-------------------LKD--EVITRIAEKHNATAA 204
Cdd:cd19103 172 SLLYRSseeagILDYCKENGITFFAYMVLeqgalsgKYDTKhplpegsgraetynpllpqLEEltAVMAEIGAKHGASIA 251
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 697052078 205 QVILAWAMGEGYAVIPSSTKRENLASNLLAADLHLDADDKKAIAAL 250
Cdd:cd19103 252 QVAIAWAIAKGTTPIIGVTKPHHVEDAARAASITLTDDEIKELEQL 297
|
|
| AKR_AKR14A1_2 |
cd19089 |
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ... |
3-243 |
1.13e-21 |
|
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.
Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 91.94 E-value: 1.13e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 3 LPAFGLGTFRLKDD-----VVIASVKTALELGYRAVDTAQIY-----ENEAAVGQALEESGVP-RNELFITTKIWIENL- 70
Cdd:cd19089 11 LPAISLGLWHNFGDytspeEARELLRTAFDLGITHFDLANNYgpppgSAEENFGRILKRDLRPyRDELVISTKAGYGMWp 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 71 -------SKDKLIPSLKESLKKLRTDYVDLTLIHWPSPNdaVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIA-- 141
Cdd:cd19089 91 gpygdggSRKYLLASLDQSLKRMGLDYVDIFYHHRYDPD--TPLEETMTALADAVRSGKALYVGISNYPGAKARRAIAll 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 142 -AVGAEnIATNQIELSpyLQNR----KVVDWAKQNGIHITSYMTLAYG-------------------------------K 185
Cdd:cd19089 169 rELGVP-LIIHQPRYS--LLDRwaedGLLEVLEEAGIGFIAFSPLAQGlltdkylngippdsrraaeskflteealtpeK 245
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 697052078 186 ALKDEVITRIAEKHNATAAQVILAWAMGEGY--AVIPSSTKRENLASNLLAAD-LHLDADD 243
Cdd:cd19089 246 LEQLRKLNKIAAKRGQSLAQLALSWVLRDPRvtSVLIGASSPSQLEDNVAALKnLDFSEEE 306
|
|
| AKR_Fe-S_oxidoreductase |
cd19096 |
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ... |
4-173 |
2.39e-19 |
|
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 84.54 E-value: 2.39e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 4 PAFGLGTFRLKD--------DVVIASVKTALELGYRAVDTAQIY---ENEAAVGQALeeSGVPRNELFITTKI-WIENLS 71
Cdd:cd19096 1 SVLGFGTMRLPEsdddsideEKAIEMIRYAIDAGINYFDTAYGYgggKSEEILGEAL--KEGPREKFYLATKLpPWSVKS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 72 KDKLIPSLKESLKKLRTDYVDLTLIHWP-SPNDAVSVEEF--MQALLEAKKQGLTREIGISnF--TIPLMEKAIAavgAE 146
Cdd:cd19096 79 AEDFRRILEESLKRLGVDYIDFYLLHGLnSPEWLEKARKGglLEFLEKAKKEGLIRHIGFS-FhdSPELLKEILD---SY 154
|
170 180 190
....*....|....*....|....*....|.
gi 697052078 147 NIATNQIELS----PYLQNRKVVDWAKQNGI 173
Cdd:cd19096 155 DFDFVQLQYNyldqENQAGRPGIEYAAKKGM 185
|
|
| AKR_AKR9A_9B |
cd19080 |
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ... |
33-242 |
3.02e-19 |
|
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 84.96 E-value: 3.02e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 33 VDTAQIYEN---EAAVGQALEESgvpRNELFITTKiWIENLSKDK----------LIPSLKESLKKLRTDYVDLTLIHWP 99
Cdd:cd19080 48 IDTANNYTNgtsERLLGEFIAGN---RDRIVLATK-YTMNRRPGDpnaggnhrknLRRSVEASLRRLQTDYIDLLYVHAW 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 100 spnDAV-SVEEFMQALLEAKKQGLTREIGISNFtiPLMEKAIAAVGAE-----NIATNQIELSpyLQNRKV----VDWAK 169
Cdd:cd19080 124 ---DFTtPVEEVMRALDDLVRAGKVLYVGISDT--PAWVVARANTLAElrgwsPFVALQIEYS--LLERTPerelLPMAR 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 170 QNGIHITSYMTLAYGK------------------------ALKD------EVITRIAEKHNATAAQVILAWAMGEGYAVI 219
Cdd:cd19080 197 ALGLGVTPWSPLGGGLltgkyqrgeegrageakgvtvgfgKLTErnwaivDVVAAVAEELGRSAAQVALAWVRQKPGVVI 276
|
250 260
....*....|....*....|....*
gi 697052078 220 PS--STKRENLASNLLAADLHLDAD 242
Cdd:cd19080 277 PIigARTLEQLKDNLGALDLTLSPE 301
|
|
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
5-250 |
1.27e-18 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 83.39 E-value: 1.27e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 5 AFGLGTF--RLKDDVVIASVKTALELGYRAVDTAQIY---ENEAAVGQALEESgvpRNELFITTK--------IWIENLS 71
Cdd:cd19087 17 CLGTMNFggRTDEETSFAIMDRALDAGINFFDTADVYgggRSEEIIGRWIAGR---RDDIVLATKvfgpmgddPNDRGLS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 72 KDKLIPSLKESLKKLRTDYVDLTLIHwpSPNDAVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIAAVGAENIATN 151
Cdd:cd19087 94 RRHIRRAVEASLRRLQTDYIDLYQMH--HFDRDTPLEETLRALDDLVRQGKIRYIGVSNFAAWQIAKAQGIAARRGLLRF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 152 QIELSPY-LQNR----KVVDWAKQNGIHITSYMTLA-------YGKALKDEV------------------------ITRI 195
Cdd:cd19087 172 VSEQPMYnLLKRqaelEILPAARAYGLGVIPYSPLAgglltgkYGKGKRPESgrlveraryqarygleeyrdiaerFEAL 251
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 697052078 196 AEKHNATAAQVILAWAMGE---GYAVIPSSTKrENLASNLLAADLHLDADDKKAIAAL 250
Cdd:cd19087 252 AAEAGLTPASLALAWVLSHpavTSPIIGPRTL-EQLEDSLAALEITLTPELLAEIDEL 308
|
|
| AKR_ARA2 |
cd19164 |
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ... |
2-142 |
5.69e-18 |
|
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 81.55 E-value: 5.69e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 2 TLPA--FGLGTF--RLKDDV----VIASVKTALELGYRAVDTAQIY-ENEAAVGQALE--ESGVPRNELFITTK-----I 65
Cdd:cd19164 12 GLPPliFGAATFsyQYTTDPesipPVDIVRRALELGIRAFDTSPYYgPSEIILGRALKalRDEFPRDTYFIITKvgrygP 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 66 WIENLSKDKLIPSLKESLKKLRTDYVDLTLIHwpspnDA--VSVEEFMQA---LLEAKKQGLTREIGISNFTIP-LMEKA 139
Cdd:cd19164 92 DDFDYSPEWIRASVERSLRRLHTDYLDLVYLH-----DVefVADEEVLEAlkeLFKLKDEGKIRNVGISGYPLPvLLRLA 166
|
...
gi 697052078 140 IAA 142
Cdd:cd19164 167 ELA 169
|
|
| AKR_AKR7A1-5 |
cd19075 |
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ... |
6-132 |
1.04e-17 |
|
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 80.68 E-value: 1.04e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 6 FGLGTF-----RLKDDVVIASVKTALELGYRAVDTAQIY---ENEAAVGQAleesGVPRNELFITTKI--WIEN-LSKDK 74
Cdd:cd19075 5 LGTMTFgsqgrFTTAEAAAELLDAFLERGHTEIDTARVYpdgTSEELLGEL----GLGERGFKIDTKAnpGVGGgLSPEN 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 697052078 75 LIPSLKESLKKLRTDYVDLTLIHwpSPNDAVSVEEFMQALLEAKKQGLTREIGISNFT 132
Cdd:cd19075 81 VRKQLETSLKRLKVDKVDVFYLH--APDRSTPLEETLAAIDELYKEGKFKEFGLSNYS 136
|
|
| AKR_unchar |
cd19099 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
1-211 |
1.61e-17 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 80.44 E-value: 1.61e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 1 MTLPAFGLGTFRL-----KDDVVIASVKTALELGYRAVDTAQIY---ENEAAVGQAL----EESGVPRNELFITTKI--- 65
Cdd:cd19099 1 LTLSSLGLGTYRGdsddeTDEEYREALKAALDSGINVIDTAINYrggRSERLIGKALreliEKGGIKRDEVVIVTKAgyi 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 66 ------------WIENLSKDKLIP------------------SLKESLKKLRTDYVDLTLIHWPSPN-DAVSVEEFMQAL 114
Cdd:cd19099 81 pgdgdeplrplkYLEEKLGRGLIDvadsaglrhcispayledQIERSLKRLGLDTIDLYLLHNPEEQlLELGEEEFYDRL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 115 LEA-------KKQGLTREIGISNFTIPLMEKA--------IAAVGAENIATN-------QIELSPYLQ------------ 160
Cdd:cd19099 161 EEAfealeeaVAEGKIRYYGISTWDGFRAPPAlpghlsleKLVAAAEEVGGDnhhfkviQLPLNLLEPealtekntvkge 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 697052078 161 NRKVVDWAKQNGIHITSYMTLAYGKALKDEVITRIAEKHNA-TAAQVILAWA 211
Cdd:cd19099 241 ALSLLEAAKELGLGVIASRPLNQGQLLGELRLADLLALPGGaTLAQRALQFA 292
|
|
| AKR_galDH |
cd19163 |
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ... |
1-140 |
3.92e-17 |
|
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 79.13 E-value: 3.92e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 1 MTLPAFGLGT------FRLKDDV-VIASVKTALELGYRAVDTAQIY---ENEAAVGQALeeSGVPRNELFITTKI----- 65
Cdd:cd19163 11 LKVSKLGFGAsplggvFGPVDEEeAIRTVHEALDSGINYIDTAPWYgqgRSETVLGKAL--KGIPRDSYYLATKVgrygl 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 66 -WIE--NLSKDKLIPSLKESLKKLRTDYVDLTLIHWP--SPNDAVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAI 140
Cdd:cd19163 89 dPDKmfDFSAERITKSVEESLKRLGLDYIDIIQVHDIefAPSLDQILNETLPALQKLKEEGKVRFIGITGYPLDVLKEVL 168
|
|
| AKR_galDH-like |
cd19153 |
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ... |
13-184 |
2.46e-16 |
|
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 76.81 E-value: 2.46e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 13 LKDDVVIASVKTALELGYRAVDTAQIYEN---EAAVGQALEESGVPRNELFITTKI-----WIENLSKDKLIPSLKESLK 84
Cdd:cd19153 30 LEQDEAVAIVAEAFAAGINHFDTSPYYGAessEAVLGKALAALQVPRSSYTVATKVgryrdSEFDYSAERVRASVATSLE 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 85 KLRTDYVDLTLIHWPSPND-AVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIAAVgaeNIATNQIELSpY----L 159
Cdd:cd19153 110 RLHTTYLDVVYLHDIEFVDyDTLVDEALPALRTLKDEGVIKRIGIAGYPLDTLTRATRRC---SPGSLDAVLS-YchltL 185
|
170 180
....*....|....*....|....*....
gi 697052078 160 QNRKVVDWA----KQNGIHITSYMTLAYG 184
Cdd:cd19153 186 QDARLESDApglvRGAGPHVINASPLSMG 214
|
|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
14-199 |
3.13e-16 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 76.92 E-value: 3.13e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 14 KDDVVIASVKTALELGYRAVDTAQIY---ENEAAVGQALeeSGVPrNELFITTKIWIENLS----KDKLIPSLKESLKKL 86
Cdd:cd19104 30 TREEQIAAVRRALDLGINFFDTAPSYgdgKSEENLGRAL--KGLP-AGPYITTKVRLDPDDlgdiGGQIERSVEKSLKRL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 87 RTDYVDLTLIH-------------WPSPNDAVSVEEFMQALLEAKKQGLTREIGISNF-TIPLMEKAIA--AVGAENIAT 150
Cdd:cd19104 107 KRDSVDLLQLHnrigderdkpvggTLSTTDVLGLGGVADAFERLRSEGKIRFIGITGLgNPPAIRELLDsgKFDAVQVYY 186
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 697052078 151 NQIELSPYLQN---------RKVVDWAKQNGIHITSYMTLAYGkALKDEVITRIAEKH 199
Cdd:cd19104 187 NLLNPSAAEARprgwsaqdyGGIIDAAAEHGVGVMGIRVLAAG-ALTTSLDRGREAPP 243
|
|
| PRK10376 |
PRK10376 |
putative oxidoreductase; Provisional |
6-243 |
7.70e-16 |
|
putative oxidoreductase; Provisional
Pssm-ID: 236676 [Multi-domain] Cd Length: 290 Bit Score: 75.39 E-value: 7.70e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 6 FGLGTFRL---------KD-DVVIASVKTALELGYRAVDTAQIYeNEAAVGQALEESGVP-RNELFITTKI--------- 65
Cdd:PRK10376 20 LGYGAMQLagpgvfgppKDrDAAIAVLREAVALGVNHIDTSDFY-GPHVTNQLIREALHPyPDDLTIVTKVgarrgedgs 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 66 WIENLSKDKLIPSLKESLKKLRT---DYVDLTL---IHWPSPNdavSVEEFMQALLEAKKQGLTREIGISNFTiplmEKA 139
Cdd:PRK10376 99 WLPAFSPAELRRAVHDNLRNLGLdvlDVVNLRLmgdGHGPAEG---SIEEPLTVLAELQRQGLVRHIGLSNVT----PTQ 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 140 IAAvgAENIAT-----NQIELSpYLQNRKVVDWAKQNGIHITSYMTLAYGKALKDEVITRIAEKHNATAAQVILAWAM-- 212
Cdd:PRK10376 172 VAE--ARKIAEivcvqNHYNLA-HRADDALIDALARDGIAYVPFFPLGGFTPLQSSTLSDVAASLGATPMQVALAWLLqr 248
|
250 260 270
....*....|....*....|....*....|.
gi 697052078 213 GEGYAVIPSSTKRENLASNLLAADLHLDADD 243
Cdd:PRK10376 249 SPNILLIPGTSSVAHLRENLAAAELVLSEEV 279
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
25-250 |
1.22e-15 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 75.29 E-value: 1.22e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 25 ALELGYRAVDTAQIY----------ENEAAVGQALEESGvPRNELFITTKI--------WI----ENLSKDKLIPSLKES 82
Cdd:cd19094 27 AFDEGVNFIDTAEMYpvppspetqgRTEEIIGSWLKKKG-NRDKVVLATKVagpgegitWPrgggTRLDRENIREAVEGS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 83 LKKLRTDYVDLTLIHWPS----------------PNDAVSVEEFMQALLEAKKQGLTREIGISNFTiP--LME--KAIAA 142
Cdd:cd19094 106 LKRLGTDYIDLYQLHWPDrytplfgggyytepseEEDSVSFEEQLEALGELVKAGKIRHIGLSNET-PwgVMKflELAEQ 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 143 VGAENIATNQIELSpyLQNRK-VVDWA----KQNgIHITSYMTLAYG----KALKDEV-------------ITR------ 194
Cdd:cd19094 185 LGLPRIVSIQNPYS--LLNRNfEEGLAeachREN-VGLLAYSPLAGGvltgKYLDGAArpeggrlnlfpgyMARyrspqa 261
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 195 ---------IAEKHNATAAQVILAWA-----MGegyAVIPSSTKRENLASNLLAADLHLDADDKKAIAAL 250
Cdd:cd19094 262 leavaeyvkLARKHGLSPAQLALAWVrsrpfVT---STIIGATTLEQLKENIDAFDVPLSDELLAEIDAV 328
|
|
| AKR_AKR13D1 |
cd19145 |
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ... |
19-247 |
2.75e-15 |
|
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 74.01 E-value: 2.75e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 19 IASVKTALELGYRAVDTAQIY---ENEAAVGQALEesGVPRNELFITTKIWIENLSKDKLI---------PSLKESLKKL 86
Cdd:cd19145 36 IALIHHAFNSGVTFLDTSDIYgpnTNEVLLGKALK--DGPREKVQLATKFGIHEIGGSGVEvrgdpayvrAACEASLKRL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 87 RTDYVDLTLIHwpSPNDAVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKA-----IAAVgaeniatnQIELSPYLQN 161
Cdd:cd19145 114 DVDYIDLYYQH--RIDTTVPIEITMGELKKLVEEGKIKYIGLSEASADTIRRAhavhpITAV--------QLEWSLWTRD 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 162 --RKVVDWAKQNGIHITSYMTLAYG----KALKDEV---------------------------ITRIAEKHNATAAQVIL 208
Cdd:cd19145 184 ieEEIIPTCRELGIGIVPYSPLGRGffagKAKLEELlensdvrkshprfqgenleknkvlyerVEALAKKKGCTPAQLAL 263
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 697052078 209 AWAMGEGYAV--IPSSTKRENLASNLLAADLHLDADDKKAI 247
Cdd:cd19145 264 AWVLHQGEDVvpIPGTTKIKNLNQNIGALSVKLTKEDLKEI 304
|
|
| AKR_AKR6C1_2 |
cd19143 |
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ... |
10-247 |
2.93e-15 |
|
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 74.17 E-value: 2.93e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 10 TF--RLKDDVVIASVKTALELGYRAVDTAQIYEN---EAAVGQALEESGVPRNELFITTKI-W-----IEN---LSKDKL 75
Cdd:cd19143 23 TFgnQVDVDEAKECMKAAYDAGVNFFDNAEVYANgqsEEIMGQAIKELGWPRSDYVVSTKIfWggggpPPNdrgLSRKHI 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 76 IPSLKESLKKLRTDYVDLTLIHWPSPNdaVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIAAVGAENIATNQIEL 155
Cdd:cd19143 103 VEGTKASLKRLQLDYVDLVFCHRPDPA--TPIEETVRAMNDLIDQGKAFYWGTSEWSAQQIEEAHEIADRLGLIPPVMEQ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 156 SPY--LQNRKV-VDWA---KQNGIHITSYMTLAYG---------------------KALKDEV-------------ITRI 195
Cdd:cd19143 181 PQYnlFHRERVeVEYAplyEKYGLGTTTWSPLASGlltgkynngipegsrlalpgyEWLKDRKeelgqekiekvrkLKPI 260
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 697052078 196 AEKHNATAAQVILAWAMGEGY--AVIPSSTKRENLASNLLAADL--HLDADDKKAI 247
Cdd:cd19143 261 AEELGCSLAQLAIAWCLKNPNvsTVITGATKVEQLEENLKALEVlpKLTPEVMEKI 316
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
12-141 |
2.73e-14 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 70.63 E-value: 2.73e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 12 RLKDDVVIASVKTALELGYRAVDTAQIYEN-EAAVGQALEESGvprnELFITTKI----WIENLSKDKLIPSLKESLKKL 86
Cdd:cd19097 22 KPSEKEAKKILEYALKAGINTLDTAPAYGDsEKVLGKFLKRLD----KFKIITKLpplkEDKKEDEAAIEASVEASLKRL 97
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 697052078 87 RTDYVDLTLIHWPSPNDAVSvEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIA 141
Cdd:cd19097 98 KVDSLDGLLLHNPDDLLKHG-GKLVEALLELKKEGLIRKIGVSVYSPEELEKALE 151
|
|
| AKR_KCAB1B_AKR6A3-like |
cd19159 |
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ... |
6-234 |
4.39e-14 |
|
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.
Pssm-ID: 381385 [Multi-domain] Cd Length: 323 Bit Score: 70.84 E-value: 4.39e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 6 FGLGTF-----RLKDDVVIASVKTALELGYRAVDTAQIY---ENEAAVGQALEESGVPRNELFITTKIWI-------ENL 70
Cdd:cd19159 16 LGLGTWvtfggQISDEVAERLMTIAYESGVNLFDTAEVYaagKAEVILGSIIKKKGWRRSSLVITTKLYWggkaeteRGL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 71 SKDKLIPSLKESLKKLRTDYVDLTLIHWPSPNdaVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIAAVGAENIAT 150
Cdd:cd19159 96 SRKHIIEGLKGSLQRLQLEYVDVVFANRPDSN--TPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 151 NQIELSPY--LQNRKV---------------VDWAK----------QNGIHITSYMTLAYGKALKDEVITR--------- 194
Cdd:cd19159 174 PVCEQAEYhlFQREKVevqlpelyhkigvgaMTWSPlacgiisgkyGNGVPESSRASLKCYQWLKERIVSEegrkqqnkl 253
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 697052078 195 -----IAEKHNATAAQVILAWAM-GEGY-AVIPSSTKRENLASNLLA 234
Cdd:cd19159 254 kdlspIAERLGCTLPQLAVAWCLrNEGVsSVLLGSSTPEQLIENLGA 300
|
|
| AKR_AKR14A2 |
cd19151 |
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ... |
3-212 |
1.85e-13 |
|
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).
Pssm-ID: 381377 [Multi-domain] Cd Length: 309 Bit Score: 68.97 E-value: 1.85e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 3 LPAFGLGTFRLKDDVVI-----ASVKTALELGYRAVDTAQIY-----ENEAAVGQALEESGVP-RNELFITTK----IWI 67
Cdd:cd19151 12 LPAISLGLWHNFGDVDRyensrAMLRRAFDLGITHFDLANNYgpppgSAEENFGRILKEDLKPyRDELIISTKagytMWP 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 68 ----ENLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPNdaVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIAAV 143
Cdd:cd19151 92 gpygDWGSKKYLIASLDQSLKRMGLDYVDIFYHHRPDPE--TPLEETMGALDQIVRQGKALYVGISNYPPEEAREAAAIL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 144 gaENIAT----NQIELSpyLQNRKV----VDWAKQNGIHITSYMTLAYG--------------------KALKDEVIT-- 193
Cdd:cd19151 170 --KDLGTpcliHQPKYS--MFNRWVeeglLDVLEEEGIGCIAFSPLAQGlltdrylngipedsraakgsSFLKPEQITee 245
|
250 260
....*....|....*....|....*...
gi 697052078 194 ---------RIAEKHNATAAQVILAWAM 212
Cdd:cd19151 246 klakvrrlnEIAQARGQKLAQMALAWVL 273
|
|
| PLN02587 |
PLN02587 |
L-galactose dehydrogenase |
13-133 |
3.02e-13 |
|
L-galactose dehydrogenase
Pssm-ID: 178198 [Multi-domain] Cd Length: 314 Bit Score: 68.27 E-value: 3.02e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 13 LKDDVVIASVKTALELGYRAVDTAQIYEN---EAAVGQALEESGVPRNELFITTKI--WIE--NLSKDKLIPSLKESLKK 85
Cdd:PLN02587 28 VSEEDAIASVREAFRLGINFFDTSPYYGGtlsEKVLGKALKALGIPREKYVVSTKCgrYGEgfDFSAERVTKSVDESLAR 107
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 697052078 86 LRTDYVDLTLIH---WPSPNDAVSveEFMQALLEAKKQGLTREIGISNFTI 133
Cdd:PLN02587 108 LQLDYVDILHCHdieFGSLDQIVN--ETIPALQKLKESGKVRFIGITGLPL 156
|
|
| Aldo_ket_red_shaker |
cd19141 |
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ... |
5-234 |
1.67e-12 |
|
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381367 [Multi-domain] Cd Length: 310 Bit Score: 65.93 E-value: 1.67e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 5 AFGLGTF-----RLKDDVVIASVKTALELGYRAVDTAQIYENEAA---VGQALEESGVPRNELFITTKI-W---IEN--- 69
Cdd:cd19141 14 CLGLGTWvtfgsQISDEVAEELVTLAYENGINLFDTAEVYAAGKAeivLGKILKKKGWRRSSYVITTKIfWggkAETerg 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 70 LSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPNdaVSVEEFMQALLEAKKQGLTREIGISNFT-IPLMEkAIAAVGAENI 148
Cdd:cd19141 94 LSRKHIIEGLKASLERLQLEYVDIVFANRPDPN--TPMEEIVRAFTHVINQGMAMYWGTSRWSaMEIME-AYSVARQFNL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 149 ATNQIELSPY--LQNRKV---------------VDWAKQ----------NGIHITSYMTLAYGKALKDEVITR------- 194
Cdd:cd19141 171 IPPIVEQAEYhlFQREKVemqlpelfhkigvgaMTWSPLacgilsgkydDGVPEYSRASLKGYQWLKEKILSEegrrqqa 250
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 697052078 195 -------IAEKHNATAAQVILAWAM-GEG-YAVIPSSTKRENLASNLLA 234
Cdd:cd19141 251 klkelqiIADRLGCTLPQLAIAWCLkNEGvSSVLLGASSTEQLYENLQA 299
|
|
| AKR_FDH |
cd19162 |
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ... |
4-129 |
4.77e-12 |
|
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 64.69 E-value: 4.77e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 4 PAFGLGT------FRLKDDVVIASVKTALELGYRAVDTAQIY---ENEAAVGQALeeSGVPRNELFITTKI--------- 65
Cdd:cd19162 1 PRLGLGAaslgnlARAGEDEAAATLDAAWDAGIRYFDTAPLYglgLSERRLGAAL--ARHPRAEYVVSTKVgrllepgaa 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 697052078 66 -------WIENLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPNDAVSVEEFMQALLEAKKQGLTREIGIS 129
Cdd:cd19162 79 grpagadRRFDFSADGIRRSIEASLERLGLDRLDLVFLHDPDRHLLQALTDAFPALEELRAEGVVGAIGVG 149
|
|
| AKR_AKR9A1-2 |
cd19146 |
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ... |
33-247 |
1.28e-11 |
|
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.
Pssm-ID: 381372 [Multi-domain] Cd Length: 326 Bit Score: 63.60 E-value: 1.28e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 33 VDTAQIY---ENEAAVGQALEESGVpRNELFITTK--IWIENLSKDK------------LIPSLKESLKKLRTDYVDLTL 95
Cdd:cd19146 52 IDTANNYqgeESERWVGEWMASRGN-RDEMVLATKytTGYRRGGPIKiksnyqgnhaksLRLSVEASLKKLQTSYIDILY 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 96 IHWpsPNDAVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIAAV------------GAENIATNQIElspylqnRK 163
Cdd:cd19146 131 VHW--WDYTTSIPELMQSLNHLVAAGKVLYLGVSDTPAWVVSKANAYArahgltqfvvyqGHWSAAFRDFE-------RD 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 164 VVDWAKQNGIHITSYMTLAYGKALKDE------------------------VITRIAEKHNATAAQVILAWAMGEGYAVI 219
Cdd:cd19146 202 ILPMCEAEGMALAPWGVLGQGQFRTEEefkrrgrsgrkggpqtekerkvseKLEKVAEEKGTAITSVALAYVMHKAPYVF 281
|
250 260 270
....*....|....*....|....*....|
gi 697052078 220 P--SSTKRENLASNLLAADLHLDADDKKAI 247
Cdd:cd19146 282 PivGGRKVEHLKGNIEALGISLSDEEIQEI 311
|
|
| AKR_KCAB2B_AKR6A1-like |
cd19158 |
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos ... |
1-234 |
9.27e-11 |
|
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens, and Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A1 (AKR6A1), A2 (AKR6A2), A4 (AKR6A4), A5 (AKR6A5), and A6 (AKR6A6), respectively. KCAB2B, also called Shaker channel b-subunit 2 (Kvb2), or K(+) channel subunit beta-2, or Kv-beta-2, or Kvbeta2, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It may be involved in the regulation of nerve signaling, and prevents neuronal hyperexcitability.
Pssm-ID: 381384 [Multi-domain] Cd Length: 324 Bit Score: 61.25 E-value: 9.27e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 1 MTLPAFGLGTF-----RLKDDVVIASVKTALELGYRAVDTAQIY---ENEAAVGQALEESGVPRNELFITTKIWI----- 67
Cdd:cd19158 11 LRVSCLGLGTWvtfggQITDEMAEHLMTLAYDNGINLFDTAEVYaagKAEVVLGNIIKKKGWRRSSLVITTKIFWggkae 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 68 --ENLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPNdaVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIAAVGA 145
Cdd:cd19158 91 teRGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPN--TPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQ 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 146 ENIATNQIELSPY--LQNRKV---------------VDWAK----------QNGIHITSYMTLAYGKALKDEVITR---- 194
Cdd:cd19158 169 FNLIPPICEQAEYhmFQREKVevqlpelfhkigvgaMTWSPlacgivsgkyDSGIPPYSRASLKGYQWLKDKILSEegrr 248
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 697052078 195 ----------IAEKHNATAAQVILAWAM-GEGY-AVIPSSTKRENLASNLLA 234
Cdd:cd19158 249 qqaklkelqaIAERLGCTLPQLAIAWCLrNEGVsSVLLGASNAEQLMENIGA 300
|
|
| AKR_AKR6B1 |
cd19142 |
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ... |
3-137 |
1.26e-10 |
|
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.
Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 60.56 E-value: 1.26e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 3 LPAFGLGTF-----RLKDDVVIASVKTALELGYRAVDTAQIYENEAA---VGQALEESGVPRNELFITTKIWIEN----- 69
Cdd:cd19142 13 VSNVGLGTWstfstAISEEQAEEIVTLAYENGINYFDTSDAFTSGQAeteLGRILKKKGWKRSSYIVSTKIYWSYgseer 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 697052078 70 -LSKDKLIPSLKESLKKLRTDYVDLTLIHwpsPNDAV-SVEEFMQALLEAKKQGLTREIGISNFT-IPLME 137
Cdd:cd19142 93 gLSRKHIIESVRASLRRLQLDYIDIVIIH---KADPMcPMEEVVRAMSYLIDNGLIMYWGTSRWSpVEIME 160
|
|
| tas |
PRK10625 |
putative aldo-keto reductase; Provisional |
20-251 |
1.43e-10 |
|
putative aldo-keto reductase; Provisional
Pssm-ID: 236727 [Multi-domain] Cd Length: 346 Bit Score: 60.64 E-value: 1.43e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 20 ASVKTALELGYRAVDTAQIYE----------NEAAVGQALEESGvPRNELFITTKIWIENLSKDKLI------------P 77
Cdd:PRK10625 34 AQLDYAVAQGINLIDVAEMYPvpprpetqglTETYIGNWLAKRG-SREKLIIASKVSGPSRNNDKGIrpnqaldrknirE 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 78 SLKESLKKLRTDYVDLTLIHWP---------------SPNDAVSVEEFMQALLEAKKQGLTREIGISNFT-------IPL 135
Cdd:PRK10625 113 ALHDSLKRLQTDYLDLYQVHWPqrptncfgklgyswtDSAPAVSLLETLDALAEQQRAGKIRYIGVSNETafgvmryLHL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 136 MEKAiaavGAENIATNQielSPY-LQNRK----VVDWAKQNGIHITSYMTLAY----GKAL--------KDEVITR---- 194
Cdd:PRK10625 193 AEKH----DLPRIVTIQ---NPYsLLNRSfevgLAEVSQYEGVELLAYSCLAFgtltGKYLngakpagaRNTLFSRftry 265
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 697052078 195 --------------IAEKHNATAAQVILAWAMGEGY--AVIPSSTKRENLASNLLAADLHLDADdkkAIAALE 251
Cdd:PRK10625 266 sgeqtqkavaayvdIAKRHGLDPAQMALAFVRRQPFvaSTLLGATTMEQLKTNIESLHLTLSEE---VLAEIE 335
|
|
| AKR_KCAB3B_AKR6A9-like |
cd19160 |
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo ... |
7-232 |
2.39e-10 |
|
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo sapiens, Rattus norvegicus, and Mus musculus, are founding members of aldo-keto reductase family 6 member A9 (AKR6A9), A12 (AKR6A12), A14 (AKR6A14), respectively. KCAB3B, also called Shaker channel b-subunit 3 (Kvb3), K(+) channel subunit beta-3, or Kv-beta-3, is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. It alters the functional properties of Kv1.5.
Pssm-ID: 381386 [Multi-domain] Cd Length: 325 Bit Score: 60.00 E-value: 2.39e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 7 GLGTF-----RLKDDVVIASVKTALELGYRAVDTAQIY---ENEAAVGQALEESGVPRNELFITTKIWI-------ENLS 71
Cdd:cd19160 19 GLGTWvtfgsQISDETAEDLLTVAYEHGVNLFDTAEVYaagKAERTLGNILKSKGWRRSSYVVTTKIYWggqaeteRGLS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 72 KDKLIPSLKESLKKLRTDYVDLTLIHWPSPNDavSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIAAVGAENIATN 151
Cdd:cd19160 99 RKHIIEGLRGSLDRLQLEYVDIVFANRSDPNS--PMEEIVRAMTYVINQGMAMYWGTSRWSAMEIMEAYSVARQFNLIPP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 152 QIELSPY--LQNRKV----VDWAKQNGIHITSYMTLAYG---------------------KALKDEVITR---------- 194
Cdd:cd19160 177 VCEQAEYhlFQREKVemqlPELYHKIGVGSVTWSPLACGlitgkydgrvpdtcraavkgyQWLKEKVQSEegkkqqakvk 256
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 697052078 195 ----IAEKHNATAAQVILAWAM-GEGY-AVIPSSTKRENLASNL 232
Cdd:cd19160 257 elhpIADRLGCTVAQLAIAWCLrSEGVsSVLLGVSSAEQLIENL 300
|
|
| AKR_AKR14A1 |
cd19150 |
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar ... |
3-236 |
6.25e-10 |
|
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins; Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.
Pssm-ID: 381376 [Multi-domain] Cd Length: 309 Bit Score: 58.62 E-value: 6.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 3 LPAFGLGTFR-LKDDVVIAS----VKTALELGYRAVDTAQIY-----ENEAAVGQALEESGVP-RNELFITTK----IWI 67
Cdd:cd19150 12 LPALSLGLWHnFGDDTPLETqraiLRTAFDLGITHFDLANNYgpppgSAEENFGRILREDFAGyRDELIISTKagydMWP 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 68 ----ENLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPNdaVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIAAV 143
Cdd:cd19150 92 gpygEWGSRKYLLASLDQSLKRMGLDYVDIFYSHRFDPD--TPLEETMGALDHAVRSGKALYVGISSYSPERTREAAAIL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 144 GAENIATNQIELSPYLQNRKV-----VDWAKQNGIHITSYMTLAYG-------------------KALKDEVITR----- 194
Cdd:cd19150 170 RELGTPLLIHQPSYNMLNRWVeesglLDTLQELGVGCIAFTPLAQGlltdkylngipegsraskeRSLSPKMLTEanlns 249
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 697052078 195 ------IAEKHNATAAQVILAWAMGEG---YAVIPSStKRENLASNLLAAD 236
Cdd:cd19150 250 iralneIAQKRGQSLAQMALAWVLRDGrvtSALIGAS-RPEQLEENVGALD 299
|
|
| PRK09912 |
PRK09912 |
L-glyceraldehyde 3-phosphate reductase; Provisional |
1-247 |
3.90e-09 |
|
L-glyceraldehyde 3-phosphate reductase; Provisional
Pssm-ID: 182140 [Multi-domain] Cd Length: 346 Bit Score: 56.54 E-value: 3.90e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 1 MTLPAFGLG-----TFRLKDDVVIASVKTALELGYRAVDTAQIY-----ENEAAVGQALEESGVP-RNELFITTK----I 65
Cdd:PRK09912 23 LRLPALSLGlwhnfGHVNALESQRAILRKAFDLGITHFDLANNYgpppgSAEENFGRLLREDFAAyRDELIISTKagydM 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 66 WI----ENLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPNdaVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIA 141
Cdd:PRK09912 103 WPgpygSGGSRKYLLASLDQSLKRMGLEYVDIFYSHRVDEN--TPMEETASALAHAVQSGKALYVGISSYSPERTQKMVE 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 142 AVGAENIATNQIELSPYLQNRKV-----VDWAKQNGIHITSYMTLAYG-----------------------KALKDEVIT 193
Cdd:PRK09912 181 LLREWKIPLLIHQPSYNLLNRWVdksglLDTLQNNGVGCIAFTPLAQGlltgkylngipqdsrmhregnkvRGLTPKMLT 260
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 697052078 194 -----------RIAEKHNATAAQVILAWAMGEG--YAVIPSSTKRENLASNLLA-ADLHLDADDKKAI 247
Cdd:PRK09912 261 eanlnslrllnEMAQQRGQSMAQMALSWLLKDErvTSVLIGASRAEQLEENVQAlNNLTFSTEELAQI 328
|
|
| AKR_AKR9A3_9B1-4 |
cd19147 |
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; ... |
27-251 |
4.86e-09 |
|
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; Phanerochaete chrysosporium ADD (EC1.1.1.91) is a founding member of aldo-keto reductase family 9 member A3. It is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). This family also includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381373 [Multi-domain] Cd Length: 319 Bit Score: 55.99 E-value: 4.86e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 27 ELGYRAVDTAQIYENEAA---VGQALEESGVpRNELFITTKIWIENLS---------------KDKLIPSLKESLKKLRT 88
Cdd:cd19147 45 EAGGNFIDTANNYQDEQSetwIGEWMKSRKN-RDQIVIATKFTTDYKAyevgkgkavnycgnhKRSLHVSVRDSLRKLQT 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 89 DYVDLTLIHWpsPNDAVSVEEFMQALLEAKKQGLTREIGIS----------NFTIPLMEKAIAAV--GAENIATNQIE-- 154
Cdd:cd19147 124 DWIDILYVHW--WDYTTSIEEVMDSLHILVQQGKVLYLGVSdtpawvvsaaNYYATAHGKTPFSVyqGRWNVLNRDFErd 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 155 -----------LSPY-------LQNRKVVDWAKQNGIHITSYMTLAYGKALK---DEVITRIAEKHN-ATAAQVILAWAM 212
Cdd:cd19147 202 iipmarhfgmaLAPWdvlgggkFQSKKAVEERKKNGEGLRSFVGGTEQTPEEvkiSEALEKVAEEHGtESVTAIALAYVR 281
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 697052078 213 GEGYAVIPS--STKRENLASNLLAADLHLDADDkkaIAALE 251
Cdd:cd19147 282 SKAPNVFPLvgGRKIEHLKDNIEALSIKLTPEE---IEYLE 319
|
|
| AKR_AKR15A |
cd19152 |
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ... |
4-128 |
8.55e-08 |
|
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381378 [Multi-domain] Cd Length: 308 Bit Score: 52.23 E-value: 8.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 4 PAFGLGT------FR-LKDDVVIASVKTALELGYRAVDTAQIYEN---EAAVGQALeeSGVPRNELFITTKI-WI----- 67
Cdd:cd19152 1 PKLGFGTaplgnlYEaVSDEEAKATLVAAWDLGIRYFDTAPWYGAglsEERLGAAL--RELGREDYVISTKVgRLlvplq 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 68 -------------------ENLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPN--DAVSVEEFMQALLEA-------KK 119
Cdd:cd19152 79 eveptfepgfwnplpfdavFDYSYDGILRSIEDSLQRLGLSRIDLLSIHDPDEDlaGAESDEHFAQAIKGAfraleelRE 158
|
....*....
gi 697052078 120 QGLTREIGI 128
Cdd:cd19152 159 EGVIKAIGL 167
|
|
| AKR_AKR15A1 |
cd19161 |
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium ... |
4-128 |
7.35e-06 |
|
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium luteolum PLD (EC1.1.1.107) is a founding member of aldo-keto reductase family 15 member A1 (AKR15A1). It catalyzes irreversible oxidation of pyridoxal.
Pssm-ID: 381387 [Multi-domain] Cd Length: 310 Bit Score: 46.16 E-value: 7.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 4 PAFGLGTFRL-------KDDVVIASVKTALELGYRAVDTAQIYEN---EAAVGQALEEsgVPRNELFITTKI-------- 65
Cdd:cd19161 1 SELGLGTAGLgnlytavSNADADATLDAAWDSGIRYFDTAPMYGHglaEHRLGDFLRE--KPRDEFVLSTKVgrllkpar 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052078 66 ---------WIENL--------SKDKLIPSLKESLKKLRTDYVDLTLIHWPSP---NDAVSVEEFMQ-------ALLEAK 118
Cdd:cd19161 79 egsvpdpngFVDPLpfeivydySYDGIMRSFEDSLQRLGLNRIDILYVHDIGVythGDRKERHHFAQlmsggfkALEELK 158
|
170
....*....|
gi 697052078 119 KQGLTREIGI 128
Cdd:cd19161 159 KAGVIKAFGL 168
|
|
| |
