|
Name |
Accession |
Description |
Interval |
E-value |
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
9-352 |
0e+00 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 680.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 9 MDCFFAAVEMRDNPALRDIPIAIGGSRVQRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAYKEASLHIRE 88
Cdd:PRK02406 1 MDCFYAAVEMRDNPELRGKPVAVGGSPGRRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQIRE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 89 IFSRYTSLIEPLSLDEAYLDVTDSVHCHGSATLMAQEIRQRIFNELNLTASAGVAPVKFLAKIASDLNKPNGQYVITPDE 168
Cdd:PRK02406 81 IFRRYTDLIEPLSLDEAYLDVTDNKLCIGSATLIAQEIRQDIFEELGLTASAGVAPNKFLAKIASDWNKPNGLFVITPEE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 169 VPAFLKTLPLGKIPGVGKVSAAKLESMGLRTCEDVQRSDLAMLLKRFGKFGRVLWERSQGIDDRDVNSERLRKSVGVERT 248
Cdd:PRK02406 161 VDAFLATLPVEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIRHFGKFGRRLYERARGIDERPVKPDRERKSVGVERT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 249 LIEDIHDWSECETIItEQLYPELERRLSKVKPDLLIARQGIKLKFNDFQQTTQEHVWPRLNKDDLIATAKKAWEERRGGR 328
Cdd:PRK02406 241 FAEDLYDLEACLAEL-PRLAEKLERRLERAKPDKRIKTVGVKLKFADFQQTTKEHTADPLDKADLIELLAQALLRRLGGR 319
|
330 340
....*....|....*....|....
gi 697052096 329 GVRLVGLHVTLLDPQLERQLVLGL 352
Cdd:PRK02406 320 GVRLLGVGVTLLEPQLERQLLLDL 343
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
5-340 |
9.57e-177 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 493.58 E-value: 9.57e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 5 IHVDMDCFFAAVEMRDNPALRDIPIAIGGSRvQRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAYKEASL 84
Cdd:cd03586 1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSS-DRGVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 85 HIREIFSRYTSLIEPLSLDEAYLDVTDSVHCHGSATLMAQEIRQRIFNELNLTASAGVAPVKFLAKIASDLNKPNGQYVI 164
Cdd:cd03586 80 QIMEILREYTPLVEPLSIDEAYLDVTDYVRLFGSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPNGLTVI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 165 TPDEVPAFLKTLPLGKIPGVGKVSAAKLESMGLRTCEDVQRSDLAMLLKRFGKFGRVLWERSQGIDDRDVNSERLRKSVG 244
Cdd:cd03586 160 PPEDVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRERKSIG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 245 VERTLIEDIHDWSECETIITEqLYPELERRLSKVKpdLLIARQGIKLKFNDFQQTTQE--HVWPRLNKDDLIATAKKAWE 322
Cdd:cd03586 240 VERTFSEDLTDPEELLEELLE-LAEELAERLRKRG--LKGRTVTVKLKYADFSTRTRSrtLPEPTDDAEDIYELALELLE 316
|
330
....*....|....*...
gi 697052096 323 ERRGGRGVRLVGLHVTLL 340
Cdd:cd03586 317 ELLDGRPIRLLGVRLSGL 334
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
2-338 |
1.26e-155 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 439.96 E-value: 1.26e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 2 RKIIHVDMDCFFAAVEMRDNPALRDIPIAIGGSRvQRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAYKE 81
Cdd:COG0389 1 RRILHVDMDAFYASVEQRDRPELRGKPVAVGGDN-NRGVVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYRD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 82 ASLHIREIFSRYTSLIEPLSLDEAYLDVTDSVHCHGSATLMAQEIRQRIFNELNLTASAGVAPVKFLAKIASDLNKPNGQ 161
Cdd:COG0389 80 VSRRVMAILERYTPLVEPLSIDEAFLDVTGSARLFGSAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKPDGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 162 YVITPDEVPAFLKTLPLGKIPGVGKVSAAKLESMGLRTCEDVQRSDLAMLLKRFGKFGRVLWERSQGIDDRDVNSERLRK 241
Cdd:COG0389 160 TVIPPGEVAAFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELRRRFGKVGERLYRLARGIDPRPVEPRRPRK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 242 SVGVERTLIEDIHDWSECETIITEqLYPELERRLSKVkpDLLIARQGIKLKFNDFQQTTQEHVWPR--LNKDDLIATAKK 319
Cdd:COG0389 240 SIGVERTFGEDLTDLEELEAALRR-LAERLAERLRRQ--GLGARTVTVKLRTSDFRTTTRSRTLPEptDDTAELLRAARE 316
|
330 340
....*....|....*....|
gi 697052096 320 AWEER-RGGRGVRLVGLHVT 338
Cdd:COG0389 317 LLERIyRPGRPVRLLGVRLS 336
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
7-154 |
6.45e-64 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 199.72 E-value: 6.45e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 7 VDMDCFFAAVEMRDNPALRDIPIAIGGSrVQRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAYKEASLHI 86
Cdd:pfam00817 1 IDMDAFFASVELLRDPELKGKPVAVGGG-NGRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKI 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 697052096 87 REIFSRYTS-LIEPLSLDEAYLDVTDSVHCHGSATLMAQEIRQRIFNELNLTASAGVAPVKFLAKIASD 154
Cdd:pfam00817 80 FEILRRFSTpKVEQASIDEAFLDLTGLEKLFGAEEALAKRLRREIAEETGLTCSIGIAPNKLLAKLASD 148
|
|
| POLXc |
smart00483 |
DNA polymerase X family; includes vertebrate polymerase beta and terminal ... |
167-289 |
5.68e-03 |
|
DNA polymerase X family; includes vertebrate polymerase beta and terminal deoxynucleotidyltransferases
Pssm-ID: 214688 Cd Length: 334 Bit Score: 38.12 E-value: 5.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 167 DEVPAFLKtlPLGKIPGVGKVSAAKLESMGLRTCEDVqRSDLAMLLKRFGKFGRVLWErsqgiddrDVNSERLRKSVGVE 246
Cdd:smart00483 82 DEVYKSLK--LFTNVFGVGPKTAAKWYRKGIRTLEEL-KKNKELKLTKQQKAGLKYYE--------DILKKVSRAEAFAV 150
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 697052096 247 RTLIEDIHDWSECETIITeqLYPELERRLSKVKP-DLLIARQGI 289
Cdd:smart00483 151 EYIVKRAVRKILPDAIVT--LTGSFRRGKETGHDvDFLITSPHP 192
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
9-352 |
0e+00 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 680.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 9 MDCFFAAVEMRDNPALRDIPIAIGGSRVQRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAYKEASLHIRE 88
Cdd:PRK02406 1 MDCFYAAVEMRDNPELRGKPVAVGGSPGRRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQIRE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 89 IFSRYTSLIEPLSLDEAYLDVTDSVHCHGSATLMAQEIRQRIFNELNLTASAGVAPVKFLAKIASDLNKPNGQYVITPDE 168
Cdd:PRK02406 81 IFRRYTDLIEPLSLDEAYLDVTDNKLCIGSATLIAQEIRQDIFEELGLTASAGVAPNKFLAKIASDWNKPNGLFVITPEE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 169 VPAFLKTLPLGKIPGVGKVSAAKLESMGLRTCEDVQRSDLAMLLKRFGKFGRVLWERSQGIDDRDVNSERLRKSVGVERT 248
Cdd:PRK02406 161 VDAFLATLPVEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIRHFGKFGRRLYERARGIDERPVKPDRERKSVGVERT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 249 LIEDIHDWSECETIItEQLYPELERRLSKVKPDLLIARQGIKLKFNDFQQTTQEHVWPRLNKDDLIATAKKAWEERRGGR 328
Cdd:PRK02406 241 FAEDLYDLEACLAEL-PRLAEKLERRLERAKPDKRIKTVGVKLKFADFQQTTKEHTADPLDKADLIELLAQALLRRLGGR 319
|
330 340
....*....|....*....|....
gi 697052096 329 GVRLVGLHVTLLDPQLERQLVLGL 352
Cdd:PRK02406 320 GVRLLGVGVTLLEPQLERQLLLDL 343
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
5-340 |
9.57e-177 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 493.58 E-value: 9.57e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 5 IHVDMDCFFAAVEMRDNPALRDIPIAIGGSRvQRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAYKEASL 84
Cdd:cd03586 1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSS-DRGVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 85 HIREIFSRYTSLIEPLSLDEAYLDVTDSVHCHGSATLMAQEIRQRIFNELNLTASAGVAPVKFLAKIASDLNKPNGQYVI 164
Cdd:cd03586 80 QIMEILREYTPLVEPLSIDEAYLDVTDYVRLFGSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPNGLTVI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 165 TPDEVPAFLKTLPLGKIPGVGKVSAAKLESMGLRTCEDVQRSDLAMLLKRFGKFGRVLWERSQGIDDRDVNSERLRKSVG 244
Cdd:cd03586 160 PPEDVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRERKSIG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 245 VERTLIEDIHDWSECETIITEqLYPELERRLSKVKpdLLIARQGIKLKFNDFQQTTQE--HVWPRLNKDDLIATAKKAWE 322
Cdd:cd03586 240 VERTFSEDLTDPEELLEELLE-LAEELAERLRKRG--LKGRTVTVKLKYADFSTRTRSrtLPEPTDDAEDIYELALELLE 316
|
330
....*....|....*...
gi 697052096 323 ERRGGRGVRLVGLHVTLL 340
Cdd:cd03586 317 ELLDGRPIRLLGVRLSGL 334
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
2-338 |
1.26e-155 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 439.96 E-value: 1.26e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 2 RKIIHVDMDCFFAAVEMRDNPALRDIPIAIGGSRvQRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAYKE 81
Cdd:COG0389 1 RRILHVDMDAFYASVEQRDRPELRGKPVAVGGDN-NRGVVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYRD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 82 ASLHIREIFSRYTSLIEPLSLDEAYLDVTDSVHCHGSATLMAQEIRQRIFNELNLTASAGVAPVKFLAKIASDLNKPNGQ 161
Cdd:COG0389 80 VSRRVMAILERYTPLVEPLSIDEAFLDVTGSARLFGSAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKPDGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 162 YVITPDEVPAFLKTLPLGKIPGVGKVSAAKLESMGLRTCEDVQRSDLAMLLKRFGKFGRVLWERSQGIDDRDVNSERLRK 241
Cdd:COG0389 160 TVIPPGEVAAFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELRRRFGKVGERLYRLARGIDPRPVEPRRPRK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 242 SVGVERTLIEDIHDWSECETIITEqLYPELERRLSKVkpDLLIARQGIKLKFNDFQQTTQEHVWPR--LNKDDLIATAKK 319
Cdd:COG0389 240 SIGVERTFGEDLTDLEELEAALRR-LAERLAERLRRQ--GLGARTVTVKLRTSDFRTTTRSRTLPEptDDTAELLRAARE 316
|
330 340
....*....|....*....|
gi 697052096 320 AWEER-RGGRGVRLVGLHVT 338
Cdd:COG0389 317 LLERIyRPGRPVRLLGVRLS 336
|
|
| PRK14133 |
PRK14133 |
DNA polymerase IV; Provisional |
1-350 |
1.36e-100 |
|
DNA polymerase IV; Provisional
Pssm-ID: 184529 [Multi-domain] Cd Length: 347 Bit Score: 300.87 E-value: 1.36e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 1 MRKIIHVDMDCFFAAVEMRDNPALRDIPIAIGGSRvQRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAYK 80
Cdd:PRK14133 2 DRVIIHVDMDAFFASVEQMDNPKLKGKPVIVGGIS-ERGVVSTCSYEARKYGVHSAMPVFMAKKRCPHGIFLPVRHERYK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 81 EASLHIREIFSRYTSLIEPLSLDEAYLDVTDsvhCHGSATLMAQEIRQRIFNELNLTASAGVAPVKFLAKIASDLNKPNG 160
Cdd:PRK14133 81 EVSKNIFKILYEVTPIVEPVSIDEAYLDITN---IKEEPIKIAKYIKKKVKKETGLTLSVGISYNKFLAKLASDWNKPDG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 161 QYVITPDEVPAFLKTLPLGKIPGVGKVSAAKLESMGLRTCEDVQRSDLAMLLKRFGKFGRVLWERSQGIDDRDVNSERLR 240
Cdd:PRK14133 158 IKIITEDMIPDILKPLPISKVHGIGKKSVEKLNNIGIYTIEDLLKLSREFLIEYFGKFGVEIYERIRGIDYREVEVSRER 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 241 KSVGVERTLIEDIHDWSECET-------IITEQLYpelERRLSkvkpdlliARQ-GIKLKFNDFQQTTQEHVwprLNK-- 310
Cdd:PRK14133 238 KSIGKETTLKKDTKDKEELKKylkdfsnIISEELK---KRNLY--------GKTvTVKIKTSDFQTHTKSKT---LNDyi 303
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 697052096 311 ---DDLIATAKKAWEERRGGRGVRLVGLHVTLLDPQLERQLVL 350
Cdd:PRK14133 304 rdkEEIYNVACEILEHINIKEPIRLIGLSVSNLSENKIEQLSF 346
|
|
| PRK02794 |
PRK02794 |
DNA polymerase IV; Provisional |
4-346 |
6.29e-99 |
|
DNA polymerase IV; Provisional
Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 298.77 E-value: 6.29e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 4 IIHVDMDCFFAAVEMRDNPALRDIPIAIGGSRvqRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAYKEAS 83
Cdd:PRK02794 38 IAHIDCDAFYASVEKRDNPELRDKPVIIGGGK--RGVVSTACYIARIHGVRSAMPMFKALKLCPDAVVIKPDMEKYVRVG 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 84 LHIREIFSRYTSLIEPLSLDEAYLDVTDSVHCHG-SATLMAQEIRQRIFNELNLTASAGVAPVKFLAKIASDLNKPNGQY 162
Cdd:PRK02794 116 REVRAMMQALTPLVEPLSIDEAFLDLSGTERLHGaPPAVVLARFARRVEREIGITVSVGLSYNKFLAKIASDLDKPRGFS 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 163 VITPDEVPAFLKTLPLGKIPGVGKVSAAKLESMGLRTCEDVQRSDLAMLLKRFGKFGRVLWERSQGIDDRDVNSERLRKS 242
Cdd:PRK02794 196 VIGRAEALAFLAPKPVGIIWGVGPATAARLARDGIRTIGDLQRADEADLMRRFGSMGLRLWRLARGIDDRKVSPDREAKS 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 243 VGVERTLIEDIHDWSECETIiteqLYPELERRLSKVKPDLLIARQ-GIKLKFNDFQQTTQEHvwpRLNK-----DDLIAT 316
Cdd:PRK02794 276 VSAETTFETDLSDFEDLEPI----LWRLSEKVSRRLKAAGLAGRTvTLKLKTADFRLRTRRR---TLEDptqlaDRIFRT 348
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 697052096 317 AKKAWEERRGGRGVRLVGLHVT------------LLDPQLER 346
Cdd:PRK02794 349 ARELLEKETDGTAFRLIGIGVSdlspadeadppdLLDPQATR 390
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
2-341 |
4.21e-92 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 281.15 E-value: 4.21e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 2 RKIIHVDMDCFFAAVEMRDNPALRDIPIAIGGS-RVQRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAYK 80
Cdd:PRK01810 5 RVIFHVDMNSFFASVEIAYDPSLQGKPLAVAGNeKERKGIIVTCSYEARAYGIRTTMPLWEAKRLCPQLIVRRPNFDRYR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 81 EASLHIREIFSRYTSLIEPLSLDEAYLDVTDSVHChGSATLMAQEIRQRIFNELNLTASAGVAPVKFLAKIASDLNKPNG 160
Cdd:PRK01810 85 EASRQMFQILSEFTPLVQPVSIDEGYLDITDCYAL-GSPLEIAKMIQQRLLTELQLPCSIGIAPNKFLAKMASDMKKPLG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 161 QYVITPDEVPAFLKTLPLGKIPGVGKVSAAKLESMGLRTCEDVQRSDLAMLLKRFGKFGRVLWERSQGIDDRDVNSERL- 239
Cdd:PRK01810 164 ITVLRKRDVPEMLWPLPVGEMHGIGEKTAEKLKDIGIQTIGDLAKADEHILRAKLGINGVRLQRRANGIDDRPVDPEAIy 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 240 -RKSVGVERTLIEDIHDWSECETIITeQLYPELERRLSKVKpdLLIARQGIKLKFNDFQQTTQEHVW--PRLNKDDLIAT 316
Cdd:PRK01810 244 qFKSVGNSTTLSHDMDEEKELLDVLR-RLSKSVSKRLQKKT--VVSYNVQIMIRYHDRRTITRSKTLknPIWEKRDIFQA 320
|
330 340
....*....|....*....|....*
gi 697052096 317 AKKAWEERRGGRGVRLVGlhVTLLD 341
Cdd:PRK01810 321 ASRLFKQHWNGDPVRLLG--VTATD 343
|
|
| PRK03348 |
PRK03348 |
DNA polymerase IV; Provisional |
1-334 |
1.25e-78 |
|
DNA polymerase IV; Provisional
Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 247.93 E-value: 1.25e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 1 MRKIIHVDMDCFFAAVEMRDNPALRDIPIAIGGSRvQRGVISTANYPARKFGVRSAMPTAMALKLCPHLT-LLPGRFEAY 79
Cdd:PRK03348 4 QRWVLHLDMDAFFASVEQLTRPTLRGRPVLVGGLG-GRGVVAGASYEARVFGARSAMPMHQARRLVGNGAvVLPPRFVVY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 80 KEASLHIREIFSRYTSLIEPLSLDEAYLD----VTDSVhchGSATLMAQEIRQRIFNELNLTASAGVAPVKFLAKIASDL 155
Cdd:PRK03348 83 RAASRRVFDTLRELSPVVEQLSFDEAFVEpaelAGASA---EEVEAFAERLRARVREETGLPASVGAGSGKQIAKIASGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 156 NKPNGQYVITPDEVPAFLKTLPLGKIPGVGKVSAAKLESMGLRTCEDVQR---SDLAMLLKRfgKFGRVLWERSQGIDDR 232
Cdd:PRK03348 160 AKPDGIRVVPPGEERELLAPLPVRRLWGIGPVTEEKLHRLGIETIGDLAAlseAEVANLLGA--TVGPALHRLARGIDDR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 233 DVNSERLRKSVGVERTLIEDIHDWSECETIItEQLYPELERRLSKvkpDLLIARQ-GIKLKFNDFQQTTQEHV--WPRLN 309
Cdd:PRK03348 238 PVAERAEAKQISAESTFAVDLTTRAQLREAI-ERIAEHAHRRLLK---DGRGARTvTVKLRKSDFSTLTRSATlpYATDD 313
|
330 340
....*....|....*....|....*
gi 697052096 310 KDDLIATAKKAWEERRGGRGVRLVG 334
Cdd:PRK03348 314 AAVLAATARRLLLDPDEIGPIRLVG 338
|
|
| PolY_Rev1 |
cd01701 |
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
2-292 |
4.33e-77 |
|
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.
Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 242.22 E-value: 4.33e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 2 RKIIHVDMDCFFAAVEMRDNPALRDIPIAIGGSRVQRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAYKE 81
Cdd:cd01701 47 RIIMHVDFDCFFVSVSIRNRPDLKGKPVAVCHGKGPNSEIASCNYEARSYGIKNGMWVGQAKKLCPQLVTLPYDFEAYEE 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 82 ASLHIREIFSRYTSLIEPLSLDEAYLDVTDSVHCHG-SATLMAQEIRQRIFNELNLTASAGVAPVKFLAKIASDLNKPNG 160
Cdd:cd01701 127 VSLTFYEILASYTDNIEAVSCDEALIDITSLLEETYeLPEELAEAIRNEIRETTGCSASVGIGPNILLARLATRKAKPDG 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 161 QYVITPDEVPAFLKTLPLGKIPGVGKVSAAKLESMGLRTCEDVQRSDLAM--LLKRFG-KFGRVLWERSQGIDDRDVNSE 237
Cdd:cd01701 207 QYHLSAEKVEEFLSQLKVGDLPGVGSSLAEKLVKLFGDTCGGLELRSKTKekLQKVLGpKTGEKLYDYCRGIDDRPVTGE 286
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 238 RLRKSVGVE-----RTLIEDihdwsECETIItEQLYPELERRLSKVKpdlLIARQgIKLK 292
Cdd:cd01701 287 KERKSVSAEinygiRFTNVD-----DVEQFL-QRLSEELSKRLEESN---VTGRQ-ITLK 336
|
|
| PRK03858 |
PRK03858 |
DNA polymerase IV; Validated |
4-350 |
9.96e-77 |
|
DNA polymerase IV; Validated
Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 241.04 E-value: 9.96e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 4 IIHVDMDCFFAAVEMRDNPALRDIPIAIGGsrvqrGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAYKEAS 83
Cdd:PRK03858 6 ILHADLDSFYASVEQRDDPALRGRPVIVGG-----GVVLAASYEAKAYGVRTAMGGRQARRLCPQAVVVPPRMSAYSRAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 84 LHIREIFSRYTSLIEPLSLDEAYLDVTDSVHCHGSATLMAQEIRQRIFNELNLTASAGVAPVKFLAKIASDLNKPNGQYV 163
Cdd:PRK03858 81 KAVFEVFRDTTPLVEGLSIDEAFLDVGGLRRISGTPVQIAARLRRRVREEVGLPITVGVARTKFLAKVASQVAKPDGLLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 164 ITPDEVPAFLKTLPLGKIPGVGKVSAAKLESMGLRTCEDVQRSDLAMLLKRFGK-FGRVLWERSQGIDDRDVNSERLRKS 242
Cdd:PRK03858 161 VPPDRELAFLHPLPVRRLWGVGPVTAAKLRAHGITTVGDVAELPESALVSLLGPaAGRHLHALAHNRDPRRVETGRRRRS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 243 VGVERTLIEDIHDWSECETIITeQLYPELERRLSKVkpdlliARQG----IKLKFNDFQQTTQEHVWPRLNKD------- 311
Cdd:PRK03858 241 VGAQRALGRGPNSPAEVDAVVV-ALVDRVARRMRAA------GRTGrtvvLRLRFDDFTRATRSHTLPRPTAStatllaa 313
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 697052096 312 --DLIATAKKAWEErrggRGVRLVGLHVTLLDPQLERQLVL 350
Cdd:PRK03858 314 arDLVAAAAPLIAE----RGLTLVGFAVSNLDDDGAQQLEL 350
|
|
| PRK03103 |
PRK03103 |
DNA polymerase IV; Reviewed |
1-350 |
1.04e-72 |
|
DNA polymerase IV; Reviewed
Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 231.43 E-value: 1.04e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 1 MRKIIHVDMDCFFAAVEMRDNPALRDIPIAIGGSRVQR-GVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAY 79
Cdd:PRK03103 2 ERVILLVDMQSFYASVEKAANPELKGRPVIVSGDPERRsGVVLAACPLAKAYGVKTAERLWEAQQKCPDLVVVKPRMQRY 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 80 KEASLHIREIFSRYTSLIEPLSLDEAYLDVTDSVHCHGSATLMAQEIRQRIFNELNLTASAGVAPVKFLAKIASDL---N 156
Cdd:PRK03103 82 IDVSLQITRILEDFTDLVEPFSIDEQFLDVTGSQKLFGSPLEIAQKIQQRIMRETGVYARVGIGPNKLLAKMACDNfakK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 157 KPNGQYVITPDEVPAFLKTLPLGKIPGVGKVSAAKLESMGLRTCEDVQRSDLAMLLKRFGKFGRVLWERSQGIDDRDVNS 236
Cdd:PRK03103 162 NPDGLFTLDKEDVPADLWPLPVRKLFGVGSRMEKHLRRMGIRTIGQLANTPLERLKKRWGINGEVLWRTANGIDYSPVTP 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 237 ERL--RKSVGVERTLIEDIHDWSECETIITEqLYPELERRlskvkpdlliARQG--------IKLKFNDFQQTTQEHVWP 306
Cdd:PRK03103 242 HSLdrQKAIGHQMTLPRDYRGFEEIKVVLLE-LCEEVCRR----------ARAKgymgrtvsVSLRGADFDWPTGFSRQM 310
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 697052096 307 RLNK-----DDLIATAKKAWEERRGGRGVRLVGLHVTLLDPQLERQLVL 350
Cdd:PRK03103 311 TLPEptnlaMEVYEAACKLFHRHWDGKPVRRVGVTLSNLVSDDVWQLSL 359
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
6-275 |
4.04e-68 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 217.23 E-value: 4.04e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 6 HVDMDCFFAAVEMRDNPALRDIPIAIGGSRVQRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAYKEASLH 85
Cdd:cd00424 2 HIDFDNFFASVEQLARPELKGRPVVVVPFNSDSTCVIACSYEARKYGVKRGMPVREARKMCPNLILVPARLDLYRRLSER 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 86 IREIFSRYTSLIEPLSLDEAYLDVTDSVHCHGSATLMAQEIRQRIFNELN-LTASAGVAPVKFLAKIASDLNKPNGQYVI 164
Cdd:cd00424 82 LLSELEEVAPLVEVASIDELFLDLTGSARLLGLGSEVALRIKRHIAEQLGgITASIGIASNKLLAKLAAKYAKPDGLTIL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 165 TPDEVPAFLKTLPLGKIPGVGKVSAAKLESMGLRTCEDVQR-SDLAMLLKRFGKFGRVLWERSQGIDDRDVNSERLRKSV 243
Cdd:cd00424 162 DPEDLPGFLSKLPLTDLPGIGAVTAKRLEAVGINPIGDLLAaSPDALLALWGGVSGERLWYALRGIDDEPLSPPRPRKSF 241
|
250 260 270
....*....|....*....|....*....|..
gi 697052096 244 GVERTLIEDIHDWSECETIItEQLYPELERRL 275
Cdd:cd00424 242 SHERVLPRDSRNAEDARPLL-RLLLEKLARRL 272
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
7-154 |
6.45e-64 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 199.72 E-value: 6.45e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 7 VDMDCFFAAVEMRDNPALRDIPIAIGGSrVQRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAYKEASLHI 86
Cdd:pfam00817 1 IDMDAFFASVELLRDPELKGKPVAVGGG-NGRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKI 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 697052096 87 REIFSRYTS-LIEPLSLDEAYLDVTDSVHCHGSATLMAQEIRQRIFNELNLTASAGVAPVKFLAKIASD 154
Cdd:pfam00817 80 FEILRRFSTpKVEQASIDEAFLDLTGLEKLFGAEEALAKRLRREIAEETGLTCSIGIAPNKLLAKLASD 148
|
|
| PolY_Pol_eta |
cd01702 |
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
6-277 |
6.80e-56 |
|
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.
Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 186.37 E-value: 6.80e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 6 HVDMDCFFAAVEMRDNPALRDIPIAIggsrVQRGVISTANYPARKFGVRSAMPTAMALKLCPHL------TLLPGRFEA- 78
Cdd:cd01702 2 HIDMDAFFAQVEQVRLGLLRNDPVAV----VQWNSIIAVSYAARAFGVTRFMTIDEAKKKCPDLilahvaTYKKGEDEAd 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 79 ----------------YKEASLHIREIFSRYTSLIEPLSLDEAYLDVTDSVhchgsatlmAQEIRQRIFNELNLTASAGV 142
Cdd:cd01702 78 yhenpsparhkvsldpYRRASRKILNILKRFGDVVEKASIDEAYLDLGSRI---------VEEIRQQVYDELGYTCSAGI 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 143 APVKFLAKIASDLNKPNGQYVITPDEVPAFLKTLPLGKIPGV-GKVSAAKLESMGLRT-CEDVQRSDLAMLLKR--FGKF 218
Cdd:cd01702 149 AHNKMLAKLASGMNKPNAQTILRNDAVASFLSSLPITSIRGLgGKLGEEIIDLLGLPTeGDVAGFRSSESDLQEhfGEKL 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 697052096 219 GRVLWERSQGIDDRDVNSERLRKSVGVERTL-------IEDIHDWsecetiiTEQLYPELERRLSK 277
Cdd:cd01702 229 GEWLYNLLRGIDHEPVKPRPLPKSMGSSKNFpgktalsTEDVQHW-------LLVLASELNSRLED 287
|
|
| PRK01216 |
PRK01216 |
DNA polymerase IV; Validated |
4-217 |
3.94e-53 |
|
DNA polymerase IV; Validated
Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 178.83 E-value: 3.94e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 4 IIHVDMDCFFAAVEMRDNPALRDIPIAI---GGSRVQRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAYK 80
Cdd:PRK01216 3 ILFVDFDYFFAQVEEVLNPSLKGKPVVVcvySGRFEDSGAVATANYEARKLGIKAGMPIVEAKKILPNAVYLPMRKEVYQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 81 EASLHIREIFSRYTSLIEPLSLDEAYLDVTDSVHCHGSATLMAQEIRQRIFNELNLTASAGVAPVKFLAKIASDLNKPNG 160
Cdd:PRK01216 83 QVSNRIMKLLREYSEKIEIASIDEAYLDISDKVKNYQDAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNG 162
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 697052096 161 QYVITPDEVPAFLKTLPLGKIPGVGKVSAAKLESMGLRTCEDVQRSDLAMLLKRFGK 217
Cdd:PRK01216 163 IKVIDDEEVKRFINELDIADIPGIGDITAEKLKKLGVNKLVDTLRIEFDELKGIIGE 219
|
|
| PTZ00205 |
PTZ00205 |
DNA polymerase kappa; Provisional |
5-323 |
1.22e-52 |
|
DNA polymerase kappa; Provisional
Pssm-ID: 140232 [Multi-domain] Cd Length: 571 Bit Score: 182.91 E-value: 1.22e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 5 IHVDMDCFFAAVEMRDNPALRDIPIAIGgsrvQRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAYKEASL 84
Cdd:PTZ00205 136 IHLDMDMFYAAVEIKKHPEYAAIPLAIG----TMTMLQTANYVARGRGIRQGMPGFLALKICPNLLILPPDFDAYNEESN 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 85 HIREIFSRYTSLIEPLSLDEAYLDVTDSVH-CHGSATL--MAQEIRQRIFNELNLTASAGVAPVKFLAKIASDLNKPNGQ 161
Cdd:PTZ00205 212 TVRRIVAEYDPNYISFGLDELTLEVSAYIErFEGTKTAedVASELRVRVFGETKLTASAGIGPTAALAKIASNINKPNGQ 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 162 YVI---TPDEVPAFLKTLPLGKIPGVGKVSAAKLESMGLRTCEDV--QRSDLAMLLK----RF---GKFGRVLWE---RS 226
Cdd:PTZ00205 292 HDLnlhTRGDVMTYVRDLGLRSVPGVGKVTEALLKGLGITTLSDIynRRVELCYILHnnlfRFllgASIGIMQWPdaaTA 371
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 227 QGIDDRDVNSERLRKSVGVERTL--IEDIHDWSECETIITEQLYPELErrlskvKPDLLIARQGIKLKFNDFQQttQEHV 304
Cdd:PTZ00205 372 ANTENCEGATGGQRKAISSERSFttPRTKEGLQEMVDTVFNGAYEEMR------KSELMCRQISLTIRWASYRY--QQYT 443
|
330
....*....|....*....
gi 697052096 305 WPRLNKDDLIATAKKAWEE 323
Cdd:PTZ00205 444 KSLIQYSDDSATLRRAVDG 462
|
|
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
5-310 |
2.94e-51 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 174.58 E-value: 2.94e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 5 IHVDMDCFFAAVEMRDNPALRDIPIAIGgsrvQRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGR-FEAYKEAS 83
Cdd:cd01703 1 IHLDLDCFYAQVEEIRDPSLKSKPLGIQ----QKYIVVTCNYEARRLGVKKLMSIKDAKEICPDLVLVNGEdLTPFRDMS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 84 LHIREIFSRYT--SLIEPLSLDEAYLDVTDSVHCHGSAtlMAQEIRQRIFNELNLTASAGVAPVKFLAKIASDLNKPNGQ 161
Cdd:cd01703 77 KKVYRLLRSYSwnDRVERLGFDENFMDVTEMRLLVASH--IAYEMRERIENELGLTCCAGIASNKLLAKLVGSVNKPNQQ 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 162 YVITP---DEVPAFLKTLPLGKIPGVGKVSAAKLESMGLRTCEDVQ-------------RSDLAMLL--KRFGK-FGRVL 222
Cdd:cd01703 155 TTLLPpscADLMDFMDLHDLRKIPGIGYKTAAKLEAHGISSVRDLQefsnrnrqtvgaaPSLLELLLmvKEFGEgIGQRI 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 223 WERSQGIDDRDVNSER-LRKSVGVERTliedihdWSECETIITEQLYPELERRLS----KVKPDLLIA-----RQGIKLK 292
Cdd:cd01703 235 WKLLFGRDTSPVKPASdFPQQISIEDS-------YKKCSLEEIREARNKIEELLAslleRMKQDLQEVkagdgRRPHTLR 307
|
330
....*....|....*...
gi 697052096 293 FNDFQQTTQEHVWPRLNK 310
Cdd:cd01703 308 LTLRRYTSTKKHYNRESK 325
|
|
| PRK03352 |
PRK03352 |
DNA polymerase IV; Validated |
1-342 |
3.38e-51 |
|
DNA polymerase IV; Validated
Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 173.67 E-value: 3.38e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 1 MRKIIHVDMDCFFAAVEMRDNPALRDIPIAIGGS---RVQRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFE 77
Cdd:PRK03352 4 PRWVLHVDLDQFIAAVELLRRPELAGLPVIVGGNgdpTEPRKVVTCASYEARAFGVRAGMPLRTAARRCPDAVFLPSDPA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 78 AYKEASLHIREIFSRYTSLIEPLSLDEAYLDVTDsvhchGSATLMAQEIRQRIFNELNLTASAGVAPVKFLAKIASDLNK 157
Cdd:PRK03352 84 AYDAASEEVMATLRDLGVPVEVWGWDEAFLGVDT-----DDPEALAEEIRAAVLERTGLSCSVGIGDNKLRAKIATGFAK 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 158 PNGQYVITPDEVPAFLKTLPLGKIPGVGKVSAAKLESMGLRTCEDVQRSDLAMLLKRFG-KFGRVLWERSQGIDDRDVNS 236
Cdd:PRK03352 159 PAGVFRLTDANWMAVMGDRPTDALWGVGPKTAKRLAALGITTVADLAAADPAELAATFGpTTGPWLLLLARGGGDTEVSA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 237 E-RLRKSVGVERTLIEDIHDWSECETIITeqlypELERRLSK--VKPDLLIARQGIKLKFNDFqqTTQEHVW----PRLN 309
Cdd:PRK03352 239 EpWVPRSRSREVTFPQDLTDRAEVESAVR-----ELARRVLDevVAEGRPVTRVAVKVRTATF--YTRTKIRklpePTTD 311
|
330 340 350
....*....|....*....|....*....|...
gi 697052096 310 KDDLIATAKKAWEERRGGRGVRLVGLHVTLLDP 342
Cdd:PRK03352 312 PDVIEAAALDVLDRFELDRPVRLLGVRLELAMP 344
|
|
| PolY_Pol_V_umuC |
cd01700 |
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
7-265 |
1.54e-40 |
|
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 145.38 E-value: 1.54e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 7 VDMDCFFAAVEMRDNPALRDIPIAIGgSRVQRGVIStANYPARKFGVRSAMPTAMALKLCP--HLTLLPGRFEAYKEASL 84
Cdd:cd01700 3 VDCNSFYASCERVFRPLLLGRPLVVL-SNNDGCVIA-RSPEAKALGIKMGSPYFKVPDLLErhGVAVFSSNYALYGDMSR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 85 HIREIFSRYTSLIEPLSLDEAYLDVTDSVHChGSATLMAQEIRQRIFNELNLTASAGVAPVKFLAKIASDL----NKPNG 160
Cdd:cd01700 81 RIMSILERFSPDVEVYSIDESFLDLTGSLRF-GDLEELARKIRRRILQETGIPVTVGIGPTKTLAKLANDLakkkNPYGG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 161 QYVITPDEVP-AFLKTLPLGKIPGVGKVSAAKLESMGLRTCEDVQRSDLAMLLKRFGKFGRVLWERSQGIDDRDV-NSER 238
Cdd:cd01700 160 VVDLTDEEVRdKLLKILPVGDVWGIGRRTAKKLNAMGIHTAGDLAQADPDLLRKKFGVVGERLVRELNGIDCLPLeEYPP 239
|
250 260
....*....|....*....|....*..
gi 697052096 239 LRKSVGVERTLIEDIHDWSECETIITE 265
Cdd:cd01700 240 PKKSIGSSRSFGRDVTDLDELKQALAE 266
|
|
| PolY_like |
cd03468 |
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ... |
19-337 |
9.01e-28 |
|
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176458 [Multi-domain] Cd Length: 335 Bit Score: 110.93 E-value: 9.01e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 19 RDNPALRDIPIAIGgSRVQRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAYKEASLHIREIFSRYTSLIE 98
Cdd:cd03468 15 RNRPADDEAPLAVV-ERKKAGRILACNAAARAAGVRPGMPLAEALALCPNLQVVEYDPEADARALQELALWLLRFTPLVA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 99 PLSLDEAYLDVTDSVHCHGSATLMAQEIRQRiFNELNLTASAGVAPVKFLAKIASDLNKPNGQYVITPDEVPAFLKTLPL 178
Cdd:cd03468 94 LDGPDGLLLDVTGCLHLFGGEDALAASLRAA-LATLGLSARAGIADTPGAAWLLARAGGGRGVLRREALAAALVLLAPLP 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 179 GKIPGVGKVSAAKLESMGLRTCEDVQRSDLAMLLKRFGKFGRVLWERSQGIDDRDVNSERLRKSVG--VERTLIEDIHDW 256
Cdd:cd03468 173 VAALRLPPETVELLARLGLRTLGDLAALPRAELARRFGLALLLRLDQAYGRDPEPLLFSPPPPAFDfrLELQLEEPIARG 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 257 SECETI-ITEQLYPELERRlskvkpDLLIARQGIKLKFNDFQQTTQEHVWPRLNkDDLIATAK------KAWEERRGGRG 329
Cdd:cd03468 253 LLFPLRrLLEQLCAFLALR------GLGARRLSLTLFREDGRVTRVLVGLARPS-RDDLPLLRllrerlERLALPRGIAP 325
|
....*...
gi 697052096 330 VRLVGLHV 337
Cdd:cd03468 326 VRLLALTA 333
|
|
| umuC |
PRK03609 |
translesion error-prone DNA polymerase V subunit UmuC; |
6-226 |
1.87e-14 |
|
translesion error-prone DNA polymerase V subunit UmuC;
Pssm-ID: 179607 [Multi-domain] Cd Length: 422 Bit Score: 74.03 E-value: 1.87e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 6 HVDMDCFFAAVEMRDNPALRDIPIAIGGSrvQRGVISTANYPARKFGVRSAMP--TAMALKLCPHLTLLPGRFEAYKEAS 83
Cdd:PRK03609 4 LCDVNSFYASCETVFRPDLRGKPVVVLSN--NDGCVIARSAEAKALGIKMGDPwfKQKDLFRRCGVVCFSSNYELYADMS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 84 LHIREIFSRYTSLIEPLSLDEAYLDVTDSVHCHgSATLMAQEIRQRIFNELNLTASAGVAPVKFLAKIASDLNKP----- 158
Cdd:PRK03609 82 NRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCR-DLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKwqrqt 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 697052096 159 NGQYVIT-PDEVPAFLKTLPLGKIPGVGKVSAAKLESMGLRTCEDVQRSDLAMLLKRFGkfgrVLWERS 226
Cdd:PRK03609 161 GGVVDLSnLERQRKLLSLQPVEEVWGVGRRISKKLNAMGIKTALDLADTNIRFIRKHFN----VVLERT 225
|
|
| IMS_C |
pfam11799 |
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). |
240-343 |
2.73e-13 |
|
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
Pssm-ID: 463354 [Multi-domain] Cd Length: 104 Bit Score: 65.27 E-value: 2.73e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 240 RKSVGVERTLIEDIHDWSECETIITEqLYPELERRLSKVKpdlLIARQ-GIKLKFNDFQQTTQEHVWPRL--NKDDLIAT 316
Cdd:pfam11799 1 RKSIGAERTFGRDLTDLEELREALLE-LAEELAERLRRQG---LVARTvTVKIRYSDFRTITRSVTLPSPtdDTDEIYRA 76
|
90 100
....*....|....*....|....*..
gi 697052096 317 AKKAWEERRGGRGVRLVGLHVTLLDPQ 343
Cdd:pfam11799 77 ALRLLRRLYRGRPVRLLGVSLSNLVPE 103
|
|
| IMS_HHH |
pfam11798 |
IMS family HHH motif; These proteins are involved in UV protection, eg. |
166-197 |
5.74e-08 |
|
IMS family HHH motif; These proteins are involved in UV protection, eg.
Pssm-ID: 432081 [Multi-domain] Cd Length: 32 Bit Score: 48.16 E-value: 5.74e-08
10 20 30
....*....|....*....|....*....|..
gi 697052096 166 PDEVPAFLKTLPLGKIPGVGKVSAAKLESMGL 197
Cdd:pfam11798 1 PDDVPEFLWPLPISKIPGIGKKLAEKLKALGI 32
|
|
| POLXc |
smart00483 |
DNA polymerase X family; includes vertebrate polymerase beta and terminal ... |
167-289 |
5.68e-03 |
|
DNA polymerase X family; includes vertebrate polymerase beta and terminal deoxynucleotidyltransferases
Pssm-ID: 214688 Cd Length: 334 Bit Score: 38.12 E-value: 5.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697052096 167 DEVPAFLKtlPLGKIPGVGKVSAAKLESMGLRTCEDVqRSDLAMLLKRFGKFGRVLWErsqgiddrDVNSERLRKSVGVE 246
Cdd:smart00483 82 DEVYKSLK--LFTNVFGVGPKTAAKWYRKGIRTLEEL-KKNKELKLTKQQKAGLKYYE--------DILKKVSRAEAFAV 150
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 697052096 247 RTLIEDIHDWSECETIITeqLYPELERRLSKVKP-DLLIARQGI 289
Cdd:smart00483 151 EYIVKRAVRKILPDAIVT--LTGSFRRGKETGHDvDFLITSPHP 192
|
|
| |
