NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|702849685|ref|WP_033283720|]
View 

MULTISPECIES: MIP/aquaporin family protein [unclassified Streptomyces]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 10001739)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11964478|8849412|11473620
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 6-259 1.71e-78

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


:

Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 236.56  E-value: 1.71e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685   6 IFIGETIGTAVLILLGGGVCAavTLKASKArNAGWLAIAFGWGFAVMTAVYISAPLSGAHLNPAVTLALAIKDG-GWDNV 84
Cdd:COG0580    5 RLLAEFLGTFILVLLGCGVVA--VLAGTKG-GIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRfPWKDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685  85 PIYWAGQLLGAMIGATLVWVAYYGQFqahltdkeivgeptakaveAEEKGAGPVLGIFSTGPEVR-NVVQNLATEIIGTV 163
Cdd:COG0580   82 LPYIIAQLLGAFLGAALVYLIYGGHF-------------------DATEDGGAKLGVFATSPAIGySLGAAFLTEIIGTF 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685 164 VLILAILtqGLNDKGNGLGTLGALITAFVVVSIGLSLGGPTGYAINPARDLGPRIVHALlplpNKGGSDWSYAWIPVVGP 243
Cdd:COG0580  143 VLVFVIL--GITDKRAAPGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHAL----GKGGSDWGYLWVPIVAP 216

                        250
                 ....*....|....*.
gi 702849685 244 LIGGAIAAGIYNLAFA 259
Cdd:COG0580  217 ILGAALAALLYRALFG 232
 
Name Accession Description Interval E-value
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 6-259 1.71e-78

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 236.56  E-value: 1.71e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685   6 IFIGETIGTAVLILLGGGVCAavTLKASKArNAGWLAIAFGWGFAVMTAVYISAPLSGAHLNPAVTLALAIKDG-GWDNV 84
Cdd:COG0580    5 RLLAEFLGTFILVLLGCGVVA--VLAGTKG-GIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRfPWKDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685  85 PIYWAGQLLGAMIGATLVWVAYYGQFqahltdkeivgeptakaveAEEKGAGPVLGIFSTGPEVR-NVVQNLATEIIGTV 163
Cdd:COG0580   82 LPYIIAQLLGAFLGAALVYLIYGGHF-------------------DATEDGGAKLGVFATSPAIGySLGAAFLTEIIGTF 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685 164 VLILAILtqGLNDKGNGLGTLGALITAFVVVSIGLSLGGPTGYAINPARDLGPRIVHALlplpNKGGSDWSYAWIPVVGP 243
Cdd:COG0580  143 VLVFVIL--GITDKRAAPGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHAL----GKGGSDWGYLWVPIVAP 216

                        250
                 ....*....|....*.
gi 702849685 244 LIGGAIAAGIYNLAFA 259
Cdd:COG0580  217 ILGAALAALLYRALFG 232
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 7-254 3.50e-50

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 166.45  E-value: 3.50e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685   7 FIGETIGTAVLILLGGGVCAAVTLKASkarNAGWLAIAFGWGFAVMTAVYISAPLSGAHLNPAVTLALA-IKDGGWDNVP 85
Cdd:PTZ00016  53 YVAEFLGTFVLLFFGEGVVATTHTVGN---NGDYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAvFGKFPWKKLP 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685  86 IYWAGQLLGAMIGATLVWVAYYGQFQAHltdkeivgeptAKAVEAEEKGAGPVLGIFSTGPEVRNvVQNLATEIIGTVVL 165
Cdd:PTZ00016 130 GYFVAQLLGAFVGAACVYGLYYGFFKDH-----------GIPELPWETMANGFAGVFATYPREGN-FYAIFSELILTAIL 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685 166 ILAILtqGLNDKgNGLGTLGALITA--FVVVSIGLSLGGPTGYAINPARDLGPRIVHALLPLPNKGGSDWSYAWIPVVGP 243
Cdd:PTZ00016 198 LLVIL--AITDP-NNCPAFNYLPVAvgLLVFVIGISFGGNTGYALNPARDLGPRLFSAILWGSEVFTKDNYYFWVPLVAP 274

                        250
                 ....*....|.
gi 702849685 244 LIGGAIAAGIY 254
Cdd:PTZ00016 275 FVGAVLGMFLY 285
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 7-256 5.22e-47

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 156.26  E-value: 5.22e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685   7 FIGETIGTAVLILLGGGVCAAVTLKASKArnAGWLAIAFGWGFAVMTAVYISAPLSGAHLNPAVTLALAI-KDGGWDNVP 85
Cdd:cd00333    3 YLAEFLGTFLLVFFGCGSVLAVKLAGGAS--GGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVgGRFPLIRVI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685  86 IYWAGQLLGAMIGATLVWVAYYGQFQAHLTdkeivgeptakaveaeekGAGPVLGIFSTGP-EVRNVVQNLATEIIGTVV 164
Cdd:cd00333   81 PYIIAQLLGAILGAALLYGLYYGLYLEFLG------------------ANNIVAGIFGTYPsPGVSNGNAFFVEFIGTFI 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685 165 LILAILTQGLNDKGNGLGTLGALITAFVVVSIGLSLGGPTGYAINPARDLGPRIVHALLplpnkggSDWSYAWIPVVGPL 244
Cdd:cd00333  143 LVLVVFATTDDPNGPPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLA-------RHWHYFWVYWVGPL 215

                        250
                 ....*....|..
gi 702849685 245 IGGAIAAGIYNL 256
Cdd:cd00333  216 IGAIAGALVYDY 227
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 9-254 1.26e-37

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 131.65  E-value: 1.26e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685    9 GETIGTAVLILLGGGVCAAVTLKASK--ARNAGWLAIAFGWGFAVMTAVYISAPLSGAHLNPAVTLALAI-KDGGWDNVP 85
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYgaVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLgRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685   86 IYWAGQLLGAMIGATLVWVAYYGQFQAHLtdkeivgeptakaveaeekgagpvlGIFSTGPEVRNVVQNLATEIIGTVVL 165
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNL-------------------------AVNGSASAGVSSGQAFFVEFIGTAIL 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685  166 ILAILTQGLNDKGNGLGTLGALITAFVVVSIGLSLGGPTGYAINPARDLGPRIVHALLPlpnkggsdWSYAWIPVVGPLI 245
Cdd:TIGR00861 136 VLVIFATTDDRNRVPRGGFAPLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGLAG--------WGNHWVYWVGPII 207


                  ....*....
gi 702849685  246 GGAIAAGIY 254
Cdd:TIGR00861 208 GAILGALVY 216
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 7-254 1.19e-32

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 118.96  E-value: 1.19e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685    7 FIGETIGTAVLILLGGGVCAAVTLKASKARNAGWLAIAFGWGFAVMTAVYISAPLSGAHLNPAVTLALAIKDG-GWDNVP 85
Cdd:pfam00230  11 VIAEFLATLLFVFFGVGSALGVKKLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRRfSLLRAI 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685   86 IYWAGQLLGAMIGATLVWVAYYGqfqahltdkeivgeptakaveaeekGAGPVLGIFSTGPEVrNVVQNLATEIIGTVVL 165
Cdd:pfam00230  91 FYIVAQLLGAIAGAALLYGVTVG-------------------------LQRAGLFANTLAPGV-NAGQAFVVEIILTFQL 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685  166 ILAILTQGLNDKGNGLGTLGALITAFVVVSIGLSLGGPTGYAINPARDLGPRIVHallplpnkggSDWSYAWIPVVGPLI 245
Cdd:pfam00230 145 VYCVFATTDDRRNGSLGTVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVL----------WKWDDHWVYWVGPFI 214


                  ....*....
gi 702849685  246 GGAIAAGIY 254
Cdd:pfam00230 215 GAALGALVY 223
 
Name Accession Description Interval E-value
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 6-259 1.71e-78

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 236.56  E-value: 1.71e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685   6 IFIGETIGTAVLILLGGGVCAavTLKASKArNAGWLAIAFGWGFAVMTAVYISAPLSGAHLNPAVTLALAIKDG-GWDNV 84
Cdd:COG0580    5 RLLAEFLGTFILVLLGCGVVA--VLAGTKG-GIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRfPWKDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685  85 PIYWAGQLLGAMIGATLVWVAYYGQFqahltdkeivgeptakaveAEEKGAGPVLGIFSTGPEVR-NVVQNLATEIIGTV 163
Cdd:COG0580   82 LPYIIAQLLGAFLGAALVYLIYGGHF-------------------DATEDGGAKLGVFATSPAIGySLGAAFLTEIIGTF 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685 164 VLILAILtqGLNDKGNGLGTLGALITAFVVVSIGLSLGGPTGYAINPARDLGPRIVHALlplpNKGGSDWSYAWIPVVGP 243
Cdd:COG0580  143 VLVFVIL--GITDKRAAPGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHAL----GKGGSDWGYLWVPIVAP 216

                        250
                 ....*....|....*.
gi 702849685 244 LIGGAIAAGIYNLAFA 259
Cdd:COG0580  217 ILGAALAALLYRALFG 232
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 7-254 3.50e-50

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 166.45  E-value: 3.50e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685   7 FIGETIGTAVLILLGGGVCAAVTLKASkarNAGWLAIAFGWGFAVMTAVYISAPLSGAHLNPAVTLALA-IKDGGWDNVP 85
Cdd:PTZ00016  53 YVAEFLGTFVLLFFGEGVVATTHTVGN---NGDYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAvFGKFPWKKLP 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685  86 IYWAGQLLGAMIGATLVWVAYYGQFQAHltdkeivgeptAKAVEAEEKGAGPVLGIFSTGPEVRNvVQNLATEIIGTVVL 165
Cdd:PTZ00016 130 GYFVAQLLGAFVGAACVYGLYYGFFKDH-----------GIPELPWETMANGFAGVFATYPREGN-FYAIFSELILTAIL 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685 166 ILAILtqGLNDKgNGLGTLGALITA--FVVVSIGLSLGGPTGYAINPARDLGPRIVHALLPLPNKGGSDWSYAWIPVVGP 243
Cdd:PTZ00016 198 LLVIL--AITDP-NNCPAFNYLPVAvgLLVFVIGISFGGNTGYALNPARDLGPRLFSAILWGSEVFTKDNYYFWVPLVAP 274

                        250
                 ....*....|.
gi 702849685 244 LIGGAIAAGIY 254
Cdd:PTZ00016 275 FVGAVLGMFLY 285
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 7-256 5.22e-47

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 156.26  E-value: 5.22e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685   7 FIGETIGTAVLILLGGGVCAAVTLKASKArnAGWLAIAFGWGFAVMTAVYISAPLSGAHLNPAVTLALAI-KDGGWDNVP 85
Cdd:cd00333    3 YLAEFLGTFLLVFFGCGSVLAVKLAGGAS--GGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVgGRFPLIRVI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685  86 IYWAGQLLGAMIGATLVWVAYYGQFQAHLTdkeivgeptakaveaeekGAGPVLGIFSTGP-EVRNVVQNLATEIIGTVV 164
Cdd:cd00333   81 PYIIAQLLGAILGAALLYGLYYGLYLEFLG------------------ANNIVAGIFGTYPsPGVSNGNAFFVEFIGTFI 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685 165 LILAILTQGLNDKGNGLGTLGALITAFVVVSIGLSLGGPTGYAINPARDLGPRIVHALLplpnkggSDWSYAWIPVVGPL 244
Cdd:cd00333  143 LVLVVFATTDDPNGPPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLA-------RHWHYFWVYWVGPL 215

                        250
                 ....*....|..
gi 702849685 245 IGGAIAAGIYNL 256
Cdd:cd00333  216 IGAIAGALVYDY 227
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 9-254 1.26e-37

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 131.65  E-value: 1.26e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685    9 GETIGTAVLILLGGGVCAAVTLKASK--ARNAGWLAIAFGWGFAVMTAVYISAPLSGAHLNPAVTLALAI-KDGGWDNVP 85
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYgaVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLgRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685   86 IYWAGQLLGAMIGATLVWVAYYGQFQAHLtdkeivgeptakaveaeekgagpvlGIFSTGPEVRNVVQNLATEIIGTVVL 165
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNL-------------------------AVNGSASAGVSSGQAFFVEFIGTAIL 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685  166 ILAILTQGLNDKGNGLGTLGALITAFVVVSIGLSLGGPTGYAINPARDLGPRIVHALLPlpnkggsdWSYAWIPVVGPLI 245
Cdd:TIGR00861 136 VLVIFATTDDRNRVPRGGFAPLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGLAG--------WGNHWVYWVGPII 207


                  ....*....
gi 702849685  246 GGAIAAGIY 254
Cdd:TIGR00861 208 GAILGALVY 216
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 7-254 1.19e-32

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 118.96  E-value: 1.19e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685    7 FIGETIGTAVLILLGGGVCAAVTLKASKARNAGWLAIAFGWGFAVMTAVYISAPLSGAHLNPAVTLALAIKDG-GWDNVP 85
Cdd:pfam00230  11 VIAEFLATLLFVFFGVGSALGVKKLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRRfSLLRAI 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685   86 IYWAGQLLGAMIGATLVWVAYYGqfqahltdkeivgeptakaveaeekGAGPVLGIFSTGPEVrNVVQNLATEIIGTVVL 165
Cdd:pfam00230  91 FYIVAQLLGAIAGAALLYGVTVG-------------------------LQRAGLFANTLAPGV-NAGQAFVVEIILTFQL 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685  166 ILAILTQGLNDKGNGLGTLGALITAFVVVSIGLSLGGPTGYAINPARDLGPRIVHallplpnkggSDWSYAWIPVVGPLI 245
Cdd:pfam00230 145 VYCVFATTDDRRNGSLGTVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVL----------WKWDDHWVYWVGPFI 214


                  ....*....
gi 702849685  246 GGAIAAGIY 254
Cdd:pfam00230 215 GAALGALVY 223
PLN00166 PLN00166
aquaporin TIP2; Provisional
 1-258 3.46e-16

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 75.74  E-value: 3.46e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685   1 MSSSDIFIGETIGTAVLILLGGGVCAAVTLKASKAR--NAGWLAIAFGWGFAVMTAVYISAPLSGAHLNPAVTLALAIkd 78
Cdd:PLN00166  15 VASLKAYLSEFIATLLFVFAGVGSAIAFAKLTSDAAldPAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAI-- 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685  79 GGwdNVPI-----YWAGQLLGAMIGATLVWVAYYGqfqahltdkeivgeptaKAVEAEEKGAGpvlgifstgpevRNVVQ 153
Cdd:PLN00166  93 GG--NITIitgffYWIAQCLGSIVACLLLVFVTNG-----------------ESVPTHGVAAG------------LGAIE 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685 154 NLATEIIGTVVLILAILTQGLNDKGNGLGTLGALITAFVVVSIGLSLGGPTGYAINPARDLGPRIVhallplpnkgGSDW 233
Cdd:PLN00166 142 GVVMEIVVTFALVYTVYATAADPKKGSLGTIAPIAIGFIVGANILAAGPFSGGSMNPARSFGPAVV----------SGDF 211

                        250       260
                 ....*....|....*....|....*
gi 702849685 234 SYAWIPVVGPLIGGAIAAGIYNLAF 258
Cdd:PLN00166 212 SQIWIYWVGPLVGGALAGLIYGDVF 236
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 7-256 9.22e-15

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 72.25  E-value: 9.22e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685   7 FIGETIGTAVLILLGGGVCAAVTLKASKARNAGwlaIAFGWGFAVMTAVYISAPLSGAHLNPAVTLALAI-KDGGWDNVP 85
Cdd:PLN00182  45 LIAEMIGTYFIIFSGCGVVVVNVLYGGTITFPG---ICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIfRRFPWYQVP 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685  86 IYWAGQLLGAMIGATLVWVAYygqfqahltdkeivgEPTAKAveaeekgagpvlgIFSTGPeVRNVVQNLATEIIGTVVL 165
Cdd:PLN00182 122 LYIGAQLTGSLLASLTLRLMF---------------NVTPEA-------------FFGTTP-TDSSGQALVAEIIISFLL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685 166 ILAIltQGLNDKGNGLGTLGALITAFVVVSIGLSLGGPTGYAINPARDLGPRIVHALlplpnkggsdWSYAWIPVVGPLI 245
Cdd:PLN00182 173 MFVI--SGVATDSRAVGELAGIAVGMTIILNVFVAGPISGASMNPARSLGPAIVMGR----------YKGIWVYIVGPFV 240

                        250
                 ....*....|.
gi 702849685 246 GGAIAAGIYNL 256
Cdd:PLN00182 241 GIIAGGFVYNL 251
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 6-256 4.49e-14

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 70.27  E-value: 4.49e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685   6 IFIGETIGTAVLILLGGGVCAAVTLKASKArnaGWLAIAFGWGFAVMTAVYISAPLSGAHLNPAVTLALAIKDG-GWDNV 84
Cdd:PLN00183  47 MVLAEMVGTFILMFCVCGIIASTQLSGGEV---GLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGHfPWSKV 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685  85 PIYWAGQLLGAmIGATLVWVAYYGqfqahltdkeivgeptakaVEAEEKGAGPVLGIFSTgpevrnvvqnLATEIIGTvv 164
Cdd:PLN00183 124 PLYITAQTVGS-VLATYVGVSVYG-------------------VKADLMTTKPAQGCSSA----------FWVEFIAT-- 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685 165 LILAILTQGLNDKGNGLGTLGALITAfVVVSIGLSLGGP-TGYAINPARDLGPRIVhallplpnkgGSDWSYAWIPVVGP 243
Cdd:PLN00183 172 FIVMFLAASLTSQPQSLGHLSGFVIG-IAIGLAVLITGPvSGGSMNPARSLGPAIV----------SWDFKDIWIYITAP 240

                        250
                 ....*....|...
gi 702849685 244 LIGGAIAAGIYNL 256
Cdd:PLN00183 241 TIGAVAGALMFHL 253
PLN00184 PLN00184
aquaporin NIP1; Provisional
 7-256 5.23e-13

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 67.35  E-value: 5.23e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685   7 FIGETIGTAVLILLGggvCAAVTLKASKARNAGWLAIAFGWGFAVMTAVYISAPLSGAHLNPAVTLALA-IKDGGWDNVP 85
Cdd:PLN00184  57 LIAEVLGTYFLVFTG---CASVVVNMQNDNVVTLPGIAIVWGLTIMVLIYSLGHISGAHINPAVTIAFAsCGRFPLKQVP 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685  86 IYWAGQLLGAMIGATLVWVaYYGQFQAHLTDKEIVgeptakaveaeekgagpVLGIFSTGPEvrnvVQNLATEIIGTVVL 165
Cdd:PLN00184 134 AYVISQVIGSTLAAATLRL-LFGLDHDVCSGKHDV-----------------FIGSSPVGSD----LQAFVMEFIVTFYL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685 166 ILAIltQGLNDKGNGLGTLGALITAFVVVSIGLSLGGPTGYAINPARDLGPRIVHALlplpnkggsdWSYAWIPVVGPLI 245
Cdd:PLN00184 192 MFII--SGVATDNRAIGELAGLAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYGC----------YKGIWIYIVAPTL 259

                        250
                 ....*....|.
gi 702849685 246 GGAIAAGIYNL 256
Cdd:PLN00184 260 GAIAGAWVYNT 270
PLN00027 PLN00027
aquaporin TIP; Provisional
 38-258 6.47e-12

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 63.65  E-value: 6.47e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685  38 AGWLAIAFGWGFAVMTAVYISAPLSGAHLNPAVTLALAIkdGGwdNVP-----IYWAGQLLGAMIGATLVWVAYYGQfqa 112
Cdd:PLN00027  56 AGLVAAALAHAFALFVAVSVGANISGGHVNPAVTFGAFI--GG--NITllrgiLYWIAQLLGSVVACLLLKFSTGGL--- 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685 113 hltdkeivgeptakaveaeekgagpVLGIFSTGPEVrNVVQNLATEIIGTVVLILAILTQGLNDKGNGLGTLGALITAFV 192
Cdd:PLN00027 129 -------------------------ETSAFSLSSGV-GVWNAFVFEIVMTFGLVYTVYATAVDPKKGDLGIIAPIAIGFI 182

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 702849685 193 VVSIGLSLGGPTGYAINPARDLGPRIVhallplpnkgGSDWSYAWIPVVGPLIGGAIAAGIYNLAF 258
Cdd:PLN00027 183 VGANILAGGAFDGASMNPAVSFGPAVV----------SWTWTNHWVYWAGPLIGGGIAGLVYELIF 238
PLN00167 PLN00167
aquaporin TIP5; Provisional
 16-255 6.11e-11

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 61.07  E-value: 6.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685  16 VLILLGGGVCAAVTLKASKARNAGWLAIAFGWGFAVMTAVYISAPLSGAHLNPAVTLALAIkdGGWDNVP---IYWAGQL 92
Cdd:PLN00167  36 VFAAVGSAMSSRKLMPDAASDPSSLLIVAIANAFALSSAVYIAANISGGHVNPAVTFGMAV--GGHISVPtamFYWISQM 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685  93 LGAMIGATLVWVAYYGQfqaHLTDKEIVGEPTAkaveaeeKGAGPVLGIFstgpevrnvvqnlateiigTVVLILAILTQ 172
Cdd:PLN00167 114 LASVMACLFLKVTTVGQ---HVPTYKIAEEMTG-------FGASVLEGVL-------------------TFGLVYTVYAA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685 173 GLNDKGNgLGTLGALITAFVVVSIGLSLGGPTGYAINPARDLGPRIVHALLplpnkggSDWSYAWipvVGPLIGGAIAAG 252
Cdd:PLN00167 165 GDPRRGL-LGAIGPLAIGLVAGANVLAAGPFSGGSMNPACAFGSAVVAGSF-------KNQAVYW---VGPLLGGAVAGL 233


                 ...
gi 702849685 253 IYN 255
Cdd:PLN00167 234 LYD 236
PLN00026 PLN00026
aquaporin NIP; Provisional
 10-254 7.40e-09

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 55.25  E-value: 7.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685  10 ETIGTAVLILLGGGVcAAVTLKASKARNAgwLAIAFGWGFAVMTAVYISAPLSGAHLNPAVTLAL-AIKDGGWDNVPIYW 88
Cdd:PLN00026  77 EFVGTFILIFAATAG-PIVNQKYDGAETL--IGNAACAGLAVMIVILSTGHISGAHLNPSLTIAFaALRHFPWKHVPAYI 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685  89 AGQLLGAMIGAtlvwVAYYGQFQahltdkeivgeptakaveaeekgagPVLGIFSTGPEVrNVVQNLATEIIGTVVLILA 168
Cdd:PLN00026 154 AAQVSASICAS----FALKGVFH-------------------------PFMSGGVTVPSV-STGQAFALEFIITFNLLFV 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685 169 ILTQGLNDKGNGlGTLGALITAFVVVSIgLSLGGPTGYAINPARDLGPRIvhallplpnkGGSDWSYAWIPVVGPLIGGA 248
Cdd:PLN00026 204 VTAVATDTRAVG-ELAGIAVGATVMLNI-LVAGPSTGGSMNPVRTLGPAV----------AAGNYRAIWIYLVAPTLGAL 271


                 ....*.
gi 702849685 249 IAAGIY 254
Cdd:PLN00026 272 AGAGTY 277
PRK05420 PRK05420
aquaporin Z; Provisional
 7-256 9.54e-09

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 54.20  E-value: 9.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685   7 FIGETIGTAVLILlgGGVCAAVTLKASKARNAGWLAIAFGWGFAVMTAVYISAPLSGAHLNPAVTLALAIkdGG---WDN 83
Cdd:PRK05420   5 LAAEFFGTFWLVF--GGCGSAVLAAAFPELGIGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWA--GGrfpAKE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685  84 VPIYWAGQLLGAMIGATLVWVAYYGQfqahlTDKEIVGEPTAKAVEAEEKGAGPVLgifstgpevrnvVQNLATEIIGTV 163
Cdd:PRK05420  81 LVPYIIAQVVGGIAAAAVLYLIASGK-----AGFDLAGSGFASNGYGEHSPGGYSL------------LAALVCEVVLTA 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685 164 VLILAILtqGLNDKGNGLGtlgalitaFVVVSIGLSLG-------GPTGYAINPARDLGPRIVhallplpnKGGSDWSYA 236
Cdd:PRK05420 144 FFLLVIL--GATDKRAPAG--------FAPIAIGLALTlihlisiPVTNTSVNPARSTGVALF--------VGGWALEQL 205

                        250       260
                 ....*....|....*....|
gi 702849685 237 WIPVVGPLIGGAIAAGIYNL 256
Cdd:PRK05420 206 WLFWVAPIVGAIIGGLIYRL 225
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 1-99 3.98e-05

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 43.46  E-value: 3.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685    1 MSSSDIFIGETIGTAVLILlgggvCAAVTLKASKARNAGWLAiAFGWGFAVMTAVYISAPLSGAHLNPAVTLALAIKDGG 80
Cdd:pfam00230 128 VNAGQAFVVEIILTFQLVY-----CVFATTDDRRNGSLGTVA-PLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWK 201

                          90
                  ....*....|....*....
gi 702849685   81 WDNVPIYWAGQLLGAMIGA 99
Cdd:pfam00230 202 WDDHWVYWVGPFIGAALGA 220
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 1-101 2.15e-04

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 41.77  E-value: 2.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685   1 MSSSDIFIGETIGTAVLILLgggvcaAVTLkASKARNAGWLAiAFGWGFAVMTAVYISAPLSGAHLNPAVTLALAIKDGG 80
Cdd:PLN00183 158 QGCSSAFWVEFIATFIVMFL------AASL-TSQPQSLGHLS-GFVIGIAIGLAVLITGPVSGGSMNPARSLGPAIVSWD 229

                         90       100
                 ....*....|....*....|.
gi 702849685  81 WDNVPIYWAGQLLGAMIGATL 101
Cdd:PLN00183 230 FKDIWIYITAPTIGAVAGALM 250
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 2-99 1.52e-03

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 39.12  E-value: 1.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685   2 SSSDIFIGETIGTAVLILLGGGVcaavtlkASKARNAGWLAiAFGWGFAVMTAVYISAPLSGAHLNPAVTLALAIKDGGW 81
Cdd:PLN00182 157 SSGQALVAEIIISFLLMFVISGV-------ATDSRAVGELA-GIAVGMTIILNVFVAGPISGASMNPARSLGPAIVMGRY 228

                         90
                 ....*....|....*...
gi 702849685  82 DNVPIYWAGQLLGAMIGA 99
Cdd:PLN00182 229 KGIWVYIVGPFVGIIAGG 246
PLN00184 PLN00184
aquaporin NIP1; Provisional
 2-104 4.59e-03

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 37.69  E-value: 4.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 702849685   2 SSSDI--FIGETIGTAVLILLGGGVcaavtlkASKARNAGWLAiAFGWGFAVMTAVYISAPLSGAHLNPAVTLALAIKDG 79
Cdd:PLN00184 174 VGSDLqaFVMEFIVTFYLMFIISGV-------ATDNRAIGELA-GLAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYG 245

                         90       100
                 ....*....|....*....|....*
gi 702849685  80 GWDNVPIYWAGQLLGAMIGAtlvWV 104
Cdd:PLN00184 246 CYKGIWIYIVAPTLGAIAGA---WV 267
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH