|
Name |
Accession |
Description |
Interval |
E-value |
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
448-815 |
6.85e-83 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 269.75 E-value: 6.85e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 448 ERFTTVLESLDAAVSVLAADEAELLFANRYYRHLFGIRPDGHLELAGGGFDSAQASSDSIDMVDTYAGLPAAALTESTAD 527
Cdd:COG4191 2 LRLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 528 AQEIYVQSIQKWFEVRRQYIQWVDGHLAQmQIATDITTRKQAQELSRQQDEKLQFTSRLMTMGEMASSLAHELNQPLAAI 607
Cdd:COG4191 82 LGLLLLLLLEALLLLLLAALDAEENAELE-ELERDITELERAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 608 NNYCSGTVALVKSGRTtPDNLLPVLEKTAQQAVRAGMIIKRIREFVKRSEPKRQATRVADIVADAVGLAEIEVRKRRIRI 687
Cdd:COG4191 161 LGNAELLRRRLEDEPD-PEELREALERILEGAERAAEIVRSLRAFSRRDEEEREPVDLNELIDEALELLRPRLKARGIEV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 688 VTDMRSRLPVIYVDPVLIEQVLVNLLKNGAEAMAEARPnavdPVIRVVVRLESGFVCISVVDQGPGVDEATAERLFEPFY 767
Cdd:COG4191 240 ELDLPPDLPPVLGDPGQLEQVLLNLLINAIDAMEEGEG----GRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFF 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 703205144 768 STKS--DGMGMGLNICRSIIESHRGRLWVVNNVESdghitGATFHCSLPI 815
Cdd:COG4191 316 TTKPvgKGTGLGLSISYGIVEKHGGRIEVESEPGG-----GTTFTITLPL 360
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
437-818 |
7.63e-66 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 226.00 E-value: 7.63e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 437 KRAREELAAAHERFTTVLESLDAAVSVLAADEaELLFANRYYRHLFGIRPDghlELAGGGFDSAQASSDSIDMVdtyagl 516
Cdd:COG5000 79 KEQREELEERRRYLETILENLPAGVIVLDADG-RITLANPAAERLLGIPLE---ELIGKPLEELLPELDLAELL------ 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 517 paAALTESTADAQEIYVQSIQKWFEVRRQYIQwVDGHLAqmqIATDITTRKQAQelsrqqdeklqftsRLMTMGEMASSL 596
Cdd:COG5000 149 --REALERGWQEEIELTRDGRRTLLVRASPLR-DDGYVI---VFDDITELLRAE--------------RLAAWGELARRI 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 597 AHELNQPLAAINNYcSGTVA--LVKSGRTTPDNLLPVLEKTAQQAVRAGMIIKRIREFVKRSEPKRQATRVADIVADAVG 674
Cdd:COG5000 209 AHEIKNPLTPIQLS-AERLRrkLADKLEEDREDLERALDTIIRQVDRLKRIVDEFLDFARLPEPQLEPVDLNELLREVLA 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 675 LAEIEVRKRRIRIVTDMRSRLPVIYVDPVLIEQVLVNLLKNGAEAMAEArpnavdPVIRVVVRLESGFVCISVVDQGPGV 754
Cdd:COG5000 288 LYEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEG------GEIEVSTRREDGRVRIEVSDNGPGI 361
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 703205144 755 DEATAERLFEPFYSTKSDGMGMGLNICRSIIESHRGRLWVVNNVEsdghiTGATFHCSLPIGEP 818
Cdd:COG5000 362 PEEVLERIFEPFFTTKPKGTGLGLAIVKKIVEEHGGTIELESRPG-----GGTTFTIRLPLAEE 420
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
317-822 |
2.86e-63 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 217.02 E-value: 2.86e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 317 AEAFFRRAMENSVlIGMRVLDMHGRITHVNPAFCRMTGWDESDLVGKTApFAYWPRDAypEMQRQLDMTLRGKAPSSGFE 396
Cdd:COG3852 5 SEELLRAILDSLP-DAVIVLDADGRITYVNPAAERLLGLSAEELLGRPL-AELFPEDS--PLRELLERALAEGQPVTERE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 397 LRVRRKDGSTFHARLYVSPLIDSSGrQTGWMSSMTDITEPKRAREELaaaherfttvlesldaavsvlaadeaellfanr 476
Cdd:COG3852 81 VTLRRKDGEERPVDVSVSPLRDAEG-EGGVLLVLRDITERKRLEREL--------------------------------- 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 477 yyrhlfgirpdghlelagggfdsaqassdsidmvdtyaglpaaaltestadaqeiyvqsiqkwfevrrqyiqwvdghlaq 556
Cdd:COG3852 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 557 mqiatdittrkqaqelsrQQDEKLQftsrlmTMGEMASSLAHELNQPLAAInnycSGTVALVKSgRTTPDNLLPVLEKTA 636
Cdd:COG3852 127 ------------------RRAEKLA------AVGELAAGLAHEIRNPLTGI----RGAAQLLER-ELPDDELREYTQLII 177
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 637 QQAVRAGMIIKRIREFVKRSEPKRQATRVADIVADAVGLAEIEVrKRRIRIVTDMRSRLPVIYVDPVLIEQVLVNLLKNG 716
Cdd:COG3852 178 EEADRLNNLVDRLLSFSRPRPPEREPVNLHEVLERVLELLRAEA-PKNIRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNA 256
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 717 AEAMAEarpnavDPVIRVVVRLESGF----------VCISVVDQGPGVDEATAERLFEPFYSTKSDGMGMGLNICRSIIE 786
Cdd:COG3852 257 AEAMPE------GGTITIRTRVERQVtlgglrprlyVRIEVIDNGPGIPEEILDRIFEPFFTTKEKGTGLGLAIVQKIVE 330
|
490 500 510
....*....|....*....|....*....|....*..
gi 703205144 787 SHRGRLWvvnnVES-DGHitGATFHCSLPIGEPDGPS 822
Cdd:COG3852 331 QHGGTIE----VESePGK--GTTFRIYLPLEQAEEEP 361
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
335-815 |
2.08e-60 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 213.05 E-value: 2.08e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 335 VLDMHGRITHVNPAFCRMTGWDESDLVGKTAPFAYWPRDAYPEMQRQLDMTlrgKAPSSGFELRVRRKDGSTFHARLYVS 414
Cdd:COG5805 49 AVNREGKVIYINPAMEKLLGYTSEEIIGKTIFDFLEKEYHYRVKTRIERLQ---KGYDVVMIEQIYCKDGELIYVEVKLF 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 415 PLIDSSGRQTGWMSSmtDITEPKRAREELAAAHERFTTVLESLDAAVSVLAaDEAELLFANRYYRHLFGIRPDghlELAG 494
Cdd:COG5805 126 PIYNQNGQAAILALR--DITKKKKIEEILQEQEERLQTLIENSPDLICVID-TDGRILFINESIERLFGAPRE---ELIG 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 495 GGFDSAQASSDSIDMVDTYAGLpAAALTESTADAQEIYVQSIQKWFEVRrqYIQWVD---GHLAQMQIATDITTRKQAQE 571
Cdd:COG5805 200 KNLLELLHPCDKEEFKERIESI-TEVWQEFIIEREIITKDGRIRYFEAV--IVPLIDtdgSVKGILVILRDITEKKEAEE 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 572 LSRQQDeklqftsRLMTMGEMASSLAHELNQPLAAINnycsGTVALVKSGRTTPDNLLPVLEktaQQAVRAGMIIKrirE 651
Cdd:COG5805 277 LMARSE-------KLSIAGQLAAGIAHEIRNPLTSIK----GFLQLLQPGIEDKEEYFDIML---SELDRIESIIS---E 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 652 FV---KRSEPKRQATRVADIVADAVGLAEIEVRKRRIRIVTDMRSRLPVIYVDPVLIEQVLVNLLKNGAEAMaearPNAV 728
Cdd:COG5805 340 FLalaKPQAVNKEKENINELIQDVVTLLETEAILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAM----PNGG 415
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 729 DPVIRVvvRLESGFVCISVVDQGPGVDEATAERLFEPFYSTKSDGMGMGLNICRSIIESHRGRLWVVNNVEsdghiTGAT 808
Cdd:COG5805 416 TITIHT--EEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKEKGTGLGLMVSYKIIENHNGTIDIDSKVG-----KGTT 488
|
....*..
gi 703205144 809 FHCSLPI 815
Cdd:COG5805 489 FTITLPL 495
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
318-815 |
3.14e-59 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 209.83 E-value: 3.14e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 318 EAFFRRAMENS---VLIgmrvLDMHGRITHVNPAFCRMTGWDESDLVGKT-APFAYwprDAYPEMQRQLDMTLRGKAPSS 393
Cdd:COG5809 14 EQRFRSLFENApdaILI----LDLEGKILKVNPAAERIFGYTEDELLGTNiLDFLH---PDDEKELREILKLLKEGESRD 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 394 GFELRVRRKDGSTFHARLYVSPLIDSSGRQTGWMSSMTDITEPKRAREELAAAHERFTTVLESLDAAVSVLAADEaELLF 473
Cdd:COG5809 87 ELEFELRHKNGKRLEFSSKLSPIFDQNGDIEGMLAISRDITERKRMEEALRESEEKFRLIFNHSPDGIIVTDLDG-RIIY 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 474 ANRYYRHLFGIrpdGHLELAGGGFDSAQASSDSIDMVdtyAGLPAAALTESTADAQEIYVQSIQKWFEVRRQYIQWVD-- 551
Cdd:COG5809 166 ANPAACKLLGI---SIEELIGKSILELIHSDDQENVA---AFISQLLKDGGIAQGEVRFWTKDGRWRLLEASGAPIKKng 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 552 GHLAQMQIATDITTRKQAQELSRQQDeklqftsRLMTMGEMASSLAHELNQPLAAINnycsGTVALVKsGRTTPDNL--L 629
Cdd:COG5809 240 EVDGIVIIFRDITERKKLEELLRKSE-------KLSVVGELAAGIAHEIRNPLTSLK----GFIQLLK-DTIDEEQKtyL 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 630 PVLEKTAQqavRAGMIIKRIREFVKRSEPKRQATRVADIVADAVGLAEIEVRKRRIRIVTDMRSRLPVIYVDPVLIEQVL 709
Cdd:COG5809 308 DIMLSELD---RIESIISEFLVLAKPQAIKYEPKDLNTLIEEVIPLLQPQALLKNVQIELELEDDIPDILGDENQLKQVF 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 710 VNLLKNGAEAMaearPNAVDPVIRVVvRLESGFVCISVVDQGPGVDEATAERLFEPFYSTKSDGMGMGLNICRSIIESHR 789
Cdd:COG5809 385 INLLKNAIEAM----PEGGNITIETK-AEDDDKVVISVTDEGCGIPEERLKKLGEPFYTTKEKGTGLGLMVSYKIIEEHG 459
|
490 500
....*....|....*....|....*.
gi 703205144 790 GRLwvvnNVESDGHItGATFHCSLPI 815
Cdd:COG5809 460 GKI----TVESEVGK-GTTFSITLPI 480
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
574-818 |
3.68e-49 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 173.55 E-value: 3.68e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 574 RQQDEKLQFTSRLMTmgEMASSLAHELNQPLAAINNYCSgtvALVKSGRTTPDNLLPVLEKTAQQAVRAGMIIKRIREFV 653
Cdd:COG2205 3 EEALEELEELERLKS--EFLANVSHELRTPLTSILGAAE---LLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 654 K----RSEPKRQATRVADIVADAVGLAEIEVRKRRIRIVTDMRSRLPVIYVDPVLIEQVLVNLLKNGAEAMAEarpnavD 729
Cdd:COG2205 78 RlesgKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPP------G 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 730 PVIRVVVRLESGFVCISVVDQGPGVDEATAERLFEPFY----STKSDGMGMGLNICRSIIESHRGRLWVVNNVESdghit 805
Cdd:COG2205 152 GTITISARREGDGVRISVSDNGPGIPEEELERIFERFYrgdnSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGG----- 226
|
250
....*....|...
gi 703205144 806 GATFHCSLPIGEP 818
Cdd:COG2205 227 GTTFTVTLPLAES 239
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
469-816 |
1.75e-44 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 163.54 E-value: 1.75e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 469 AELLFANRYYRHLFGIRPDGHLELAGGGFDSAQASSDSIDMVDTYAGLPAAALTESTADAQEIYVQSIQKWFEVRRQYIQ 548
Cdd:COG0642 3 LLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 549 WVDGHLAQMQIATDITTRKQAQELSRQQdeklqftsrlmtmGEMASSLAHELNQPLAAInnycSGTVALVKsgRTTPDNL 628
Cdd:COG0642 83 LLLLLLLLLLLLLLLALLLLLEEANEAK-------------SRFLANVSHELRTPLTAI----RGYLELLL--EELDEEQ 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 629 LPVLEKTAQQAVRAGMIIKRIREFVK----RSEPKRQATRVADIVADAVGLAEIEVRKRRIRIVTDMRSRLPVIYVDPVL 704
Cdd:COG0642 144 REYLETILRSADRLLRLINDLLDLSRleagKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDR 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 705 IEQVLVNLLKNGAEAMAEARPnavdpvIRVVVRLESGFVCISVVDQGPGVDEATAERLFEPFYSTKSD----GMGMGLNI 780
Cdd:COG0642 224 LRQVLLNLLSNAIKYTPEGGT------VTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSrrggGTGLGLAI 297
|
330 340 350
....*....|....*....|....*....|....*.
gi 703205144 781 CRSIIESHRGRLWVVNNVEsdghiTGATFHCSLPIG 816
Cdd:COG0642 298 VKRIVELHGGTIEVESEPG-----KGTTFTVTLPLA 328
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
449-818 |
1.43e-41 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 157.02 E-value: 1.43e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 449 RFTTVLESLDAAVSVLAADEAELLFANRYYRHLFGIRPDGHLELAGGGFDSAQASSDSIDMVDTYAGLPAAALTESTADA 528
Cdd:COG5002 41 LLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 529 QEIYVQSIQKWFEVRRQYIQWVDGHLAQMQIATDITTRKQAQELSRqqdeklqftsrlmtmgEMASSLAHELNQPLAAIN 608
Cdd:COG5002 121 LSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRR----------------EFVANVSHELRTPLTSIR 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 609 NYCSgtvALVKSGRTTPDNLLPVLEKTAQQAVRAGMIIKRIREFVK----RSEPKRQATRVADIVADAVGLAEIEVRKRR 684
Cdd:COG5002 185 GYLE---LLLDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRlesgELKLEKEPVDLAELLEEVVEELRPLAEEKG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 685 IRIVTDMRSRLPVIYVDPVLIEQVLVNLLKNGAEAMAEarpnavDPVIRVVVRLESGFVCISVVDQGPGVDEATAERLFE 764
Cdd:COG5002 262 IELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPE------GGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFE 335
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 765 PFY------STKSDGMGMGLNICRSIIESHRGRLWVVNNVESdghitGATFHCSLPIGEP 818
Cdd:COG5002 336 RFYrvdksrSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGK-----GTTFTITLPLARE 390
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
310-571 |
1.10e-39 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 147.48 E-value: 1.10e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 310 EAQQALYAEAFFRRAMENSVLIGMRVLDMHGRITHVNPAFCRMTGWDESDLVGKTAPFAYWPRDAyPEMQRQLDMTLRGK 389
Cdd:COG2202 1 TAEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDD-DEFLELLRAALAGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 390 APSSGfELRVRRKDGSTFHARLYVSPLIDSSGRQTGWMSSMTDITEPKRAREELAAAHERFTTVLESLDAAVSVLAADeA 469
Cdd:COG2202 80 GVWRG-ELRNRRKDGSLFWVELSISPVRDEDGEITGFVGIARDITERKRAEEALRESEERLRLLVENAPDGIFVLDLD-G 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 470 ELLFANRYYRHLFGIRPDghlELAGGGFDSAQASSDSIDMVDTYAGLPAAALTESTADAQEIYVQSIQKWFEVRRQYIQW 549
Cdd:COG2202 158 RILYVNPAAEELLGYSPE---ELLGKSLLDLLHPEDRERLLELLRRLLEGGRESYELELRLKDGDGRWVWVEASAVPLRD 234
|
250 260
....*....|....*....|..
gi 703205144 550 VDGHLAQMQIATDITTRKQAQE 571
Cdd:COG2202 235 GGEVIGVLGIVRDITERKRAEE 256
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
315-818 |
1.41e-39 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 153.79 E-value: 1.41e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 315 LYAEAFFRRAMENSVLIGMRVLDMHGRITHVNPAFCRMTGWDESDLVGKTAPFAYWPRDAYPEMQRQLDMTLRGKAPSSG 394
Cdd:COG4251 1 LLLLALLLLLLLLLLLLLLLLLLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 395 FELRVRRKDGSTFHARLYVSPLIDSSGRQTGWMSSMTDITEPKRAREELAAAHERFTTVLESLDAAVSVLAADEAELLFA 474
Cdd:COG4251 81 LLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 475 NRYYRHLFGIRPDGHLELAGGGFDSAQASSDSIDMVDTYAGLPAAALTESTADAQEIYVQSIQKWFEVRRQYIQWVDGHL 554
Cdd:COG4251 161 LLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 555 AQMQIATDITTRKQAQ---ELSRQQDEKLQFTSRLMT----MGEMASSLAHELNQPLAAINNYCSgtvaLVKS--GRTTP 625
Cdd:COG4251 241 LILLLLLLILVLELLElrlELEELEEELEERTAELERsneeLEQFAYVASHDLREPLRKISGFSQ----LLEEdyGDKLD 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 626 DNLLPVLEKTAQQAVRAGMIIKRIREF--VKRSEPKRQATRVADIVADAVGLAEIEVRKRRIRIVTDmrsRLPVIYVDPV 703
Cdd:COG4251 317 EEGREYLERIRDAAERMQALIDDLLAYsrVGRQELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVG---PLPTVRGDPT 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 704 LIEQVLVNLLKNGAEAMAEARPnavdPVIRVVVRLESGFVCISVVDQGPGVDEATAERLFEPFY----STKSDGMGMGLN 779
Cdd:COG4251 394 LLRQVFQNLISNAIKYSRPGEP----PRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQrlhsRDEYEGTGIGLA 469
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 703205144 780 ICRSIIESHRGRLWvvnnVESD-GHitGATFHCSLPIGEP 818
Cdd:COG4251 470 IVKKIVERHGGRIW----VESEpGE--GATFYFTLPKAPA 503
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
558-799 |
8.10e-39 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 153.69 E-value: 8.10e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 558 QIATDITTRKQAQELSRQQDEKLQFTSRLMTMGEMASSLAHELNQPLAAINNYC-SGTVALVKSGrttPDNLLPVLEKTA 636
Cdd:COG4192 402 ELETEIEERKRIEKNLRQTQDELIQAAKMAVVGQTMTSLAHELNQPLNAMSMYLfSAKKALEQEN---YAQLPTSLDKIE 478
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 637 QQAVRAGMIIKRIREFVKRSEPKRQATRVADIVADAVGLAEIEVRKRRIRIVTDMRsrlPVIYVDPVLIEQVLVNLLKNG 716
Cdd:COG4192 479 GLIERMDKIIKSLRQFSRKSDTPLQPVDLRQVIEQAWELVESRAKPQQITLHIPDD---LMVQGDQVLLEQVLVNLLVNA 555
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 717 AEAMAEArpnavdPVIRVVVRLESGFVCISVVDQGPGVdeATAERLFEPFYSTKSDGMGMGLNICRSIIESHRGRLWVVN 796
Cdd:COG4192 556 LDAVATQ------PQISVDLLSNAENLRVAISDNGNGW--PLVDKLFTPFTTTKEVGLGLGLSICRSIMQQFGGDLYLAS 627
|
...
gi 703205144 797 NVE 799
Cdd:COG4192 628 TLE 630
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
562-821 |
2.38e-38 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 151.66 E-value: 2.38e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 562 DITTRKQAQELSRQQDeklqftsRLMTMGEMASSLAHELNQPLAAINNYCSgtvALVKSGRTTP-DNLLPVLektAQQAV 640
Cdd:PRK11360 370 DLTERKRLQRRVARQE-------RLAALGELVAGVAHEIRNPLTAIRGYVQ---IWRQQTSDPPsQEYLSVV---LREVD 436
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 641 RAGMIIKRIREFVKRSEPKRQATRVADIVADAVGLAEIEVRKRRIRIVTDMRSRLPVIYVDPVLIEQVLVNLLKNGAEAM 720
Cdd:PRK11360 437 RLNKVIDQLLEFSRPRESQWQPVSLNALVEEVLQLFQTAGVQARVDFETELDNELPPIWADPELLKQVLLNILINAVQAI 516
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 721 AEarpnavDPVIRVVVRLES-GFVCISVVDQGPGVDEATAERLFEPFYSTKSDGMGMGLNICRSIIESHRGRLWVVNNVE 799
Cdd:PRK11360 517 SA------RGKIRIRTWQYSdGQVAVSIEDNGCGIDPELLKKIFDPFFTTKAKGTGLGLALSQRIINAHGGDIEVESEPG 590
|
250 260
....*....|....*....|..
gi 703205144 800 SdghitGATFHCSLPIGEPDGP 821
Cdd:PRK11360 591 V-----GTTFTLYLPINPQGNQ 607
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
705-814 |
2.01e-37 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 135.60 E-value: 2.01e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 705 IEQVLVNLLKNGAEAMAEARPNAVDPVIRVVvRLESGFVCISVVDQGPGVDEATAERLFEPFYSTKSDGMGMGLNICRSI 784
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGCERRELTIRTS-PADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSI 79
|
90 100 110
....*....|....*....|....*....|
gi 703205144 785 IESHRGRLWVVNNVESdghitGATFHCSLP 814
Cdd:cd16920 80 IEAHGGRLSVESPAGG-----GATFQFTLP 104
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
455-835 |
2.22e-31 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 131.72 E-value: 2.22e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 455 ESLDAAVSVLAADEAELLFANRYYRHlfgiRPDGHLELAGGGFDS--AQASSDSIDmvdtyaglpaAALTestadaqeiy 532
Cdd:PRK13837 341 DRLRALASTVKAAERDVVFVDRNGPV----RKRSCLTRRGPALWAclAFKSGDRIV----------ALLG---------- 396
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 533 vqsiqkwFEVRRQYIQWVDGHLAQMQIATDitTRKQAQELSRQQDEK------LQFTSRLMTMGEMASSLAHELNQPLAA 606
Cdd:PRK13837 397 -------LGRQRYGLRPPAGELQLLELALD--CLAHAIERRRLETERdalerrLEHARRLEAVGTLASGIAHNFNNILGA 467
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 607 INNYCSGTVALVKSGRTTPDNLLPVLEKTAqqavRAGMIIKRIREFVKRSEPKRQATRVADIVADAVGLAEIEVrKRRIR 686
Cdd:PRK13837 468 ILGYAEMALNKLARHSRAARYIDEIISAGA----RARLIIDQILAFGRKGERNTKPFDLSELVTEIAPLLRVSL-PPGVE 542
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 687 IVTDMRSRLPVIYVDPVLIEQVLVNLLKNGAEAMAEA-----RPNAVDpvIRVVVRLESG------FVCISVVDQGPGVD 755
Cdd:PRK13837 543 LDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAgrvdiSLSRAK--LRAPKVLSHGvlppgrYVLLRVSDTGAGID 620
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 756 EATAERLFEPFYSTKSDGMGMGLNICRSIIESHRGRLWVVNNVesdGHitGATFHCSLPIGEPdgPSNGGSEAPTPQTVT 835
Cdd:PRK13837 621 EAVLPHIFEPFFTTRAGGTGLGLATVHGIVSAHAGYIDVQSTV---GR--GTRFDVYLPPSSK--VPVAPQAFFGPGPLP 693
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
578-814 |
9.41e-29 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 119.59 E-value: 9.41e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 578 EKLQFTSRLMTMGEMASSLAHELNQPLAAINnycsGTVALVKSGRTTPDNLLPVLEKTAQQAVRAGMIIKRIREFVKRSE 657
Cdd:COG5806 190 KELQRAEKLEVVSELAASIAHEVRNPLTVVR----GFIQLLQEPELSDEKRKQYIRIALEELDRAEAIITDYLTFAKPQP 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 658 PKRQATRVADIVADAVGLAEIEVRKRRIRIVTDMRSRLpVIYVDPVLIEQVLVNLLKNGAEAMaearPNavDPVIRVVVR 737
Cdd:COG5806 266 EKLEKIDVSEELEHVIDVLSPYANMNNVEIQTELEPGL-YIEGDRQKLQQCLINIIKNGIEAM----PN--GGTLTIDVS 338
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 703205144 738 LESGFVCISVVDQGPGVDEATAERLFEPFYSTKSDGMGMGLNICRSIIESHRGRLwvvnNVESDGHiTGATFHCSLP 814
Cdd:COG5806 339 IDKNKVIISIKDTGVGMTKEQLERLGEPYFSTKEKGTGLGTMVSYRIIEAMNGTI----RVESEVG-KGTTFTITLP 410
|
|
| sensory_box |
TIGR00229 |
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ... |
318-443 |
1.51e-26 |
|
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]
Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 105.07 E-value: 1.51e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 318 EAFFRRAMENSVlIGMRVLDMHGRITHVNPAFCRMTGWDESDLVGKTAPFaYWPRDAYPEMQRQLDMTLRGKAPSSGFEL 397
Cdd:TIGR00229 2 EERYRAIFESSP-DAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLE-LIPEEDREEVRERIERRLEGEPEPVSEER 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 703205144 398 RVRRKDGSTFHARLYVSPlIDSSGRQTGWMSSMTDITEPKRAREEL 443
Cdd:TIGR00229 80 RVRRKDGSEIWVEVSVSP-IRTNGGELGVVGIVRDITERKEAEEAL 124
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
701-815 |
1.83e-26 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 104.27 E-value: 1.83e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 701 DPVLIEQVLVNLLKNGAEAMAEarpnavDPVIRVVVRLESGFVCISVVDQGPGVDEATAERLFEPFYSTKSD-----GMG 775
Cdd:smart00387 2 DPDRLRQVLSNLLDNAIKYTPE------GGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRsrkigGTG 75
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 703205144 776 MGLNICRSIIESHRGRLWVVNNVEsdghiTGATFHCSLPI 815
Cdd:smart00387 76 LGLSIVKKLVELHGGEISVESEPG-----GGTTFTITLPL 110
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
437-817 |
2.12e-26 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 112.25 E-value: 2.12e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 437 KRAREELAAAHERFTTVLESLDAAVSVLAADEaELLFANRYYRHLFGIRPDGHlelagggfdsaqassdsidmvdTYAGL 516
Cdd:COG3290 73 LKLLEEIARLVEEREAVLESIREGVIAVDRDG-RITLINDAARRLLGLDAIGR----------------------PIDEV 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 517 PAAALTESTADaQEIYVQsiQKWFEVRRQYIQWVDGHLAQMQIATDITtrkqaqELSRQQDEklqfTSRLMTMGEMASSL 596
Cdd:COG3290 130 LAEVLETGERD-EEILLN--GRVLVVNRVPIRDDGRVVGAVATFRDRT------ELERLEEE----LEGVKELAEALRAQ 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 597 AHELNQPLAAInnycsgtVALVKSGRTtpdnllpvlektaQQAVRagmIIKRIREfVKRSEPKRQATRVADIVADAVGLA 676
Cdd:COG3290 197 RHDFRNHLHTI-------SGLLQLGEY-------------DEALE---YIDEISE-ELQELIDSLLSRIGNPVLAALLLG 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 677 EI-EVRKRRIRIVTDMRSRLPVIYVDPVLIEQVLVNLLKNGAEAMAEARPNavDPVIRVVVRLESGFVCISVVDQGPGVD 755
Cdd:COG3290 253 KAaRARERGIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAIEAVEKLPEE--ERRVELSIRDDGDELVIEVEDSGPGIP 330
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 703205144 756 EATAERLFEPFYSTK-SDGMGMGLNICRSIIESHRGRLWVVNNVEsdghiTGATFHCSLPIGE 817
Cdd:COG3290 331 EELLEKIFERGFSTKlGEGRGLGLALVKQIVEKYGGTIEVESEEG-----EGTVFTVRLPKEG 388
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
533-815 |
7.55e-25 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 107.34 E-value: 7.55e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 533 VQSIQKWFEVRRQYIQWVDGHLAQMQiATDITTRKQAQELSRQQDE-------------KLQFTSRLMTMgemassLAHE 599
Cdd:PRK09303 89 FQQLKNWWPRWQQEGATYSGLGENLQ-PSEIDSGRYSQELLQLSDElfvlrqenetlleQLKFKDRVLAM------LAHD 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 600 LNQPLAAinnycsGTVAL--VKSGRTTPDNLLPV--LEKTAQQAVRAGMIIKR----IREFVKRSEPK----RQATRVAD 667
Cdd:PRK09303 162 LRTPLTA------ASLALetLELGQIDEDTELKPalIEQLQDQARRQLEEIERlitdLLEVGRTRWEAlrfnPQKLDLGS 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 668 IVADAVGLAEIEVRKRRIRIVTDMRSRLPVIYVDPVLIEQVLVNLLKNgaeAMAEARPNAVdpvIRVVV--RlESGFVCI 745
Cdd:PRK09303 236 LCQEVILELEKRWLAKSLEIQTDIPSDLPSVYADQERIRQVLLNLLDN---AIKYTPEGGT---ITLSMlhR-TTQKVQV 308
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 703205144 746 SVVDQGPGVDEATAERLFEPFYSTKSD----GMGMGLNICRSIIESHRGRLWVVNNVESdghitGATFHCSLPI 815
Cdd:PRK09303 309 SICDTGPGIPEEEQERIFEDRVRLPRDegteGYGIGLSVCRRIVRVHYGQIWVDSEPGQ-----GSCFHFTLPV 377
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
705-813 |
1.97e-24 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 98.44 E-value: 1.97e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 705 IEQVLVNLLKNGAEAMAEarpnavDPVIRVVVRLESGFVCISVVDQGPGVDEATAERLFEPFYSTKSD----GMGMGLNI 780
Cdd:cd00075 1 LEQVLSNLLDNALKYSPP------GGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSreggGTGLGLAI 74
|
90 100 110
....*....|....*....|....*....|...
gi 703205144 781 CRSIIESHRGRLWVVNNVEsdghiTGATFHCSL 813
Cdd:cd00075 75 VRRIVEAHGGRITVESEPG-----GGTTFTVTL 102
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
566-794 |
2.61e-23 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 104.10 E-value: 2.61e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 566 RKQAQELSRQQDEKLQFTSRLMTMGEMASSLAHELNQPLAAINNYCSGTVALVKSGrTTPDNLLPVLektAQQAVRAGMI 645
Cdd:PRK10364 214 YRRYLRSRQLLQDEMKRKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFAERAPAG-GEAHQLAQVM---AKEADRLNRV 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 646 IKRIREFVKRSEPKRQATRVADIVADAVGLAEIEVRKRRIRIVTDMRSRLPVIYVDPVLIEQVLVNLLKNGAEAMAEarp 725
Cdd:PRK10364 290 VSELLELVKPTHLALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQ--- 366
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 703205144 726 navDPVIRVVVRLESGFVCISVVDQGPGVDEATAERLFEPFYSTKSDGMGMGLNICRSIIESHRGRLWV 794
Cdd:PRK10364 367 ---HGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQV 432
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
701-814 |
2.22e-21 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 89.73 E-value: 2.22e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 701 DPVLIEQVLVNLLKNGAEAMAEARPnavdpvIRVVVRlESGFVCISVVDQGPGVDEATAERLFEPFYS---TKSDGMGMG 777
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGE------ITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPFSTadkRGGGGTGLG 74
|
90 100 110
....*....|....*....|....*....|....*..
gi 703205144 778 LNICRSIIESHRGRLWVVNNVEsdghiTGATFHCSLP 814
Cdd:pfam02518 75 LSIVRKLVELLGGTITVESEPG-----GGTTVTLTLP 106
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
705-809 |
2.81e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 89.44 E-value: 2.81e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 705 IEQVLVNLLKNGAEAMAEARpnavDPVIRVVVRLESGFVCISVVDQGPGVDEATAERLFEPFYSTK--SDGMGMGLNICR 782
Cdd:cd16976 1 IQQVLMNLLQNALDAMGKVE----NPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKpvGKGTGLGLSISY 76
|
90 100
....*....|....*....|....*..
gi 703205144 783 SIIESHRGRLWVVNnvESDGhitGATF 809
Cdd:cd16976 77 GIVEEHGGRLSVAN--EEGA---GARF 98
|
|
| nifL_nitrog |
TIGR02938 |
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ... |
321-790 |
2.02e-20 |
|
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]
Pssm-ID: 131984 [Multi-domain] Cd Length: 494 Bit Score: 95.74 E-value: 2.02e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 321 FRRAMENSVlIGMRVLDMHGRITHVNPAFCRMTGWDESDLVGKTAPFAYwPRDAYPEMQRQLDMTLRGKAPSSGfELRVR 400
Cdd:TIGR02938 6 YRQTVDQAP-LAISITDLKANILYANDAFTRITGYTKEEIIGKNESVLS-NHTTPPEVYQALWGSLAEQKPWAG-KLLNR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 401 RKDGSTFHARLYVSPLIDSSGRQTGWMSSMTDITEPKRAREELAAAHERFTTVLESLDAAVSVLAADEAELLFANRYYRH 480
Cdd:TIGR02938 83 RKDGELYLAELTVAPVLNEAGETTHFLGMHRDITELHRLEQVVANQKLLIESVVDAAPVAFVLLDPTGRVILDNQEYKKL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 481 LFGIRPDGhlelagggfdSAQASSDSIdmvdtyagLPAAALTESTADAQEIYVQSIQ-----------KWFEVRRQYIQW 549
Cdd:TIGR02938 163 ATDLRVKE----------PAHTVLDLL--------REAWREALAENWPQQLAFSNREarfdrgggrpaRWLSCTGSVIGM 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 550 ----VDGHLAQMQ------IATDITTRKQAQELSRQQDEK--LQFTSRLMTMGEMASSLAHELNQPLaainNYCSGTVAL 617
Cdd:TIGR02938 225 esdcADSFFCAAEqpylllTIADISNLREEQERARLSALQalMAEEERLEAIRETLSAAIHRLQGPM----NLISAAISV 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 618 VKsgRTTPDNLLPVLEKTAQQAVRAGMiikRIREFVKRSEPKRQATRVADIVADAVGLAEIEVRKRRIR---IVTDMR-- 692
Cdd:TIGR02938 301 LQ--RRGDDAGNPASAAMLQQALSAGR---EHMEALRQVIPQSPQEIVVPVNLNQILRDVITLSTPRLLaagIVVDWQpa 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 693 SRLPVIYVDPVLIEQVLVNLLKNGAEAMAEARPNAVDpvIRVVVRLESGFVCISVVDQGPGVDEATAERLFEPFYSTKSD 772
Cdd:TIGR02938 376 ATLPAILGRELQLRSLFKALVDNAIEAMNIKGWKRRE--LSITTALNGDLIVVSILDSGPGIPQDLRYKVFEPFFTTKGG 453
|
490 500
....*....|....*....|.
gi 703205144 773 ---GMGMGLNICRSIIESHRG 790
Cdd:TIGR02938 454 srkHIGMGLSVAQEIVADHGG 474
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
701-809 |
3.76e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 86.44 E-value: 3.76e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 701 DPVLIEQVLVNLLKNGAEAmAEARPnavDPVIRVVVRLESGFV---CISVVDQGPGVDEATAERLFEPFYSTKSDGMGMG 777
Cdd:cd16944 1 DTTQISQVLTNILKNAAEA-IEGRP---SDVGEVRIRVEADQDgriVLIVCDNGKGFPREMRHRATEPYVTTRPKGTGLG 76
|
90 100 110
....*....|....*....|....*....|..
gi 703205144 778 LNICRSIIESHRGRLwVVNNVESDGHITGATF 809
Cdd:cd16944 77 LAIVKKIMEEHGGRI-SLSNREAGGACIRIIL 107
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
319-433 |
1.24e-19 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 85.16 E-value: 1.24e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 319 AFFRRAMENSVlIGMRVLDMHGRITHVNPAFCRMTGWDESDLVGKTaPFAYWPRDAYPEMQRQLDMTLRGKAPSSGFELR 398
Cdd:pfam00989 1 EDLRAILESLP-DGIFVVDEDGRILYVNAAAEELLGLSREEVIGKS-LLDLIPEEDDAEVAELLRQALLQGEESRGFEVS 78
|
90 100 110
....*....|....*....|....*....|....*
gi 703205144 399 VRRKDGSTFHARLYVSPLIDSSGRQTGWMSSMTDI 433
Cdd:pfam00989 79 FRVPDGRPRHVEVRASPVRDAGGEILGFLGVLRDI 113
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
667-818 |
3.24e-19 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 93.18 E-value: 3.24e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 667 DIVADAVGLAEIEVRKRRIRIvtDMRSRLPVIYVDPVLIEQVLVNLLKNGAEAMAEARPNAVDpvirvvVRLESGFVCIS 746
Cdd:PRK10490 743 EVVGSALQMLEPGLSGHPINL--SLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQAEIGID------AHVEGERLQLD 814
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 703205144 747 VVDQGPGVDEATAERLFEPFYSTKSD----GMGMGLNICRSIIESHRGRLWVVNNVESdghitGATFHCSLPIGEP 818
Cdd:PRK10490 815 VWDNGPGIPPGQEQLIFDKFARGNKEsaipGVGLGLAICRAIVEVHGGTIWAENRPEG-----GACFRVTLPLETP 885
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
307-443 |
7.41e-19 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 87.00 E-value: 7.41e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 307 QRFEAQQAL-YAEAFFRRAMENSvLIGMRVLDMHGRITHVNPAFCRMTGWDESDLVGKTaPFAYWPRDAYPEMQRQLDMT 385
Cdd:COG2202 124 ERKRAEEALrESEERLRLLVENA-PDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKS-LLDLLHPEDRERLLELLRRL 201
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 703205144 386 LRGKAPSSGFELRVRRKDGSTFHARLYVSPLIDsSGRQTGWMSSMTDITEPKRAREEL 443
Cdd:COG2202 202 LEGGRESYELELRLKDGDGRWVWVEASAVPLRD-GGEVIGVLGIVRDITERKRAEEAL 258
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
595-802 |
1.54e-18 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 89.52 E-value: 1.54e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 595 SLAHELNQPLAAInnycSGTVALVKSGrTTPDNLLPVLEKTAQQAVRAGMIIKRIREFVK---RSEP-KRQATRVADIVA 670
Cdd:PRK11100 262 TLTHELKSPLAAI----RGAAELLQED-PPPEDRARFTGNILTQSARLQQLIDRLLELARleqRQELeVLEPVALAALLE 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 671 DAVGLAEIEVRKRRIRIvtdmRSRLPVIYV--DPVLIEQVLVNLLKNgaeAMAEARPNAVdpvIRVVVRLESGFVCISVV 748
Cdd:PRK11100 337 ELVEAREAQAAAKGITL----RLRPDDARVlgDPFLLRQALGNLLDN---AIDFSPEGGT---ITLSAEVDGEQVALSVE 406
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 703205144 749 DQGPGVDEATAERLFEPFYST-------KSDgmGMGLNICRSIIESHRGRLwVVNNVESDG 802
Cdd:PRK11100 407 DQGPGIPDYALPRIFERFYSLprpangrKST--GLGLAFVREVARLHGGEV-TLRNRPEGG 464
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
332-433 |
9.02e-17 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 76.52 E-value: 9.02e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 332 GMRVLDMHGRITHVNPAFCRMTGWDESDLVGKTApFAYWPRDAYPEMQRQLDMTLRGKAPSSgFELRVRRKDGSTFHARL 411
Cdd:cd00130 4 GVIVLDLDGRILYANPAAEQLLGYSPEELIGKSL-LDLIHPEDREELRERLENLLSGGEPVT-LEVRLRRKDGSVIWVLV 81
|
90 100
....*....|....*....|..
gi 703205144 412 YVSPLIDSSGRQTGWMSSMTDI 433
Cdd:cd00130 82 SLTPIRDEGGEVIGLLGVVRDI 103
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
705-814 |
2.69e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 75.06 E-value: 2.69e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 705 IEQVLVNLLKNGAEAMAEARPnavdPVIRVVVRLESGFVCISVVDQGPGVDEATAERLFEPFYSTKSD----GMGMGLNI 780
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRP----PRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSReeyeGTGVGLAI 76
|
90 100 110
....*....|....*....|....*....|....
gi 703205144 781 CRSIIESHRGRLWvvnnVESdGHITGATFHCSLP 814
Cdd:cd16921 77 VRKIIERHGGRIW----LES-EPGEGTTFYFTLP 105
|
|
| PRK09776 |
PRK09776 |
putative diguanylate cyclase; Provisional |
308-451 |
4.43e-16 |
|
putative diguanylate cyclase; Provisional
Pssm-ID: 182070 [Multi-domain] Cd Length: 1092 Bit Score: 83.18 E-value: 4.43e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 308 RFEAQQALYAEAFFRRAMENSVlIGMRVLDMHGRITHVNPAFCRMTGWDESDLVGKTAPFAYWPRDAYPEMqRQLDMTLR 387
Cdd:PRK09776 272 RAERKHISESETRFRNAMEYSA-IGMALVGTEGQWLQVNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL-QQVEKLLS 349
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 703205144 388 GKAPSSGFELRVRRKDGSTFHARLYVSPLIDSSGRQTGWMSSMTDITEPKRAREELAAAHERFT 451
Cdd:PRK09776 350 GEINSYSMEKRYYRRDGEVVWALLAVSLVRDTDGTPLYFIAQIEDINELKRTEQVNERLMERIT 413
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
702-815 |
5.99e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 74.38 E-value: 5.99e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 702 PVLIEQVLVNLLKNGAEAM-AEARpnavdpvIRVVVRLESGFVCISVVDQGPGVDEATAERLFEPFYSTK--SDGMGMGL 778
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAMeGRGR-------ITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKpvGEGTGLGL 73
|
90 100 110
....*....|....*....|....*....|....*...
gi 703205144 779 NICRSIIESHRGRLwvvnNVES-DGHitGATFHCSLPI 815
Cdd:cd16943 74 SLSYRIIQKHGGTI----RVASvPGG--GTRFTIILPI 105
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
566-815 |
1.40e-15 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 78.97 E-value: 1.40e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 566 RKQAQELSRQQDeklQFTSRLMTMGemassLAHELNQPLAAINnycsGTVALVksGRTTPDnllPVLEKTAQqavragMI 645
Cdd:PRK11073 115 RRLSQEQLQHAQ---QVAARDLVRG-----LAHEIKNPLGGLR----GAAQLL--SKALPD---PALTEYTK------VI 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 646 IK---RIREFVKR----SEPKRQATRVADIVADAV-GLAEIEVrKRRIRIVTDMRSRLPVIYVDPVLIEQVLVNLLKNGA 717
Cdd:PRK11073 172 IEqadRLRNLVDRllgpQRPGTHVTESIHKVAERVvQLVSLEL-PDNVRLIRDYDPSLPELAHDPDQIEQVLLNIVRNAL 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 718 EAMAEA------RPNAVDPVI------RVVVRlesgfvcISVVDQGPGVDEATAERLFEPFYSTKSDGMGMGLNICRSII 785
Cdd:PRK11073 251 QALGPEggtitlRTRTAFQLTlhgeryRLAAR-------IDIEDNGPGIPPHLQDTLFYPMVSGREGGTGLGLSIARNLI 323
|
250 260 270
....*....|....*....|....*....|.
gi 703205144 786 ESHRGRLwvvnNVES-DGHitgATFHCSLPI 815
Cdd:PRK11073 324 DQHSGKI----EFTSwPGH---TEFSVYLPI 347
|
|
| PAS_9 |
pfam13426 |
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ... |
339-435 |
1.52e-15 |
|
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463873 [Multi-domain] Cd Length: 93 Bit Score: 72.49 E-value: 1.52e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 339 HGRITHVNPAFCRMTGWDESDLVGKTAPFAYWPRDAypemQRQLDMTLRGKAPSSGFELRVRRKDGSTFHARLYVSPLID 418
Cdd:pfam13426 1 DGRIIYVNDAALRLLGYTREELLGKSITDLFAEPED----SERLREALREGKAVREFEVVLYRKDGEPFPVLVSLAPIRD 76
|
90
....*....|....*..
gi 703205144 419 SSGRQTGWMSSMTDITE 435
Cdd:pfam13426 77 DGGELVGIIAILRDITE 93
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
705-814 |
9.29e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 70.89 E-value: 9.29e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 705 IEQVLVNLLKNGAEAMAEArpnavDPVIRVVVRLESGF---------VC-ISVVDQGPGVDEATAERLFEPFYSTKSDGM 774
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGS-----GGEIILRTRTQRQVtlghprhrlALrVSVIDNGPGIPPDLQDTIFYPMVSGRENGT 75
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 703205144 775 GMGLNICRSIIESHRGRlwvvnnVESDGHITGATFHCSLP 814
Cdd:cd16918 76 GLGLAIAQNIVSQHGGV------IECDSQPGHTVFSVSLP 109
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
739-814 |
2.77e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 69.28 E-value: 2.77e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 739 ESGFVCISVVDQGPGVDEATAERLFEPFY------STKSDGMGMGLNICRSIIESHRGRLWVvnnveSDGHITGATFHCS 812
Cdd:cd16949 27 DGDQWTITITDDGPGVPEDQLEQIFLPFYrvdsarDRESGGTGLGLAIAERAIEQHGGKIKA-----SNRKPGGLRVRIW 101
|
..
gi 703205144 813 LP 814
Cdd:cd16949 102 LP 103
|
|
| PEP_his_kin |
TIGR02916 |
putative PEP-CTERM system histidine kinase; Members of this protein family have a novel ... |
564-794 |
2.85e-13 |
|
putative PEP-CTERM system histidine kinase; Members of this protein family have a novel N-terminal domain, a single predicted membrane-spanning helix, and a predicted cystosolic histidine kinase domain. We designate this protein PrsK, and its companion DNA-binding response regulator protein (TIGR02915) PrsR. These predicted signal-transducing proteins appear to enable enhancer-dependent transcriptional activation. The prsK gene is often associated with exopolysaccharide biosynthesis genes. [Protein fate, Protein and peptide secretion and trafficking, Signal transduction, Two-component systems]
Pssm-ID: 274349 [Multi-domain] Cd Length: 679 Bit Score: 73.60 E-value: 2.85e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 564 TTRKQAQELSRQQ-DEKLQFTSRLMTMGEMASSLAHELNQPLAAInnycSGTVALVKSGRTTPDNLLPVLEKTAQQAVRA 642
Cdd:TIGR02916 449 AGRQAASYLAQMEaSEALAEARQFEAFNRMSAFVVHDLKNLVAQL----SLLLRNAERHKDNPEFQDDMLETVENAVNRM 524
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 643 GMIIKRIREfvKRSEPKRQATRVADIVADAVGLAEIEVRKRRIRIVTDMRSRlpviyVDPVLIEQVLVNLLKNGAEAMAE 722
Cdd:TIGR02916 525 KKLLAQLRS--KGLEEEKLCVDLVDLLRRAIASKRAQGPRPEVSIDTDLSVR-----ADRERLERVLGHLVQNALEATPG 597
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 703205144 723 ARpnavdpviRVVVRLES--GFVCISVVDQGPGVDEA-TAERLFEPFYSTKSDGMGMGLNICRSIIESHRGRLWV 794
Cdd:TIGR02916 598 EG--------RVAIRVERecGAARIEIEDSGCGMSPAfIRERLFKPFDTTKGAGMGIGVYECRQYVEEIGGRIEV 664
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
562-778 |
5.29e-13 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 72.40 E-value: 5.29e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 562 DITTRKQAQELSRQQdEKLQftsrlmTMGEMASSLAHELNQPLAAINNYCSGTVALVKSGRTTPDNLLPVLEKTAQQAVR 641
Cdd:PRK13557 143 DVSRRRDAEDALRQA-QKME------ALGQLTGGIAHDFNNLLQVMSGYLDVIQAALSHPDADRGRMARSVENIRAAAER 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 642 AGMIIKRIREFVKRsepKRQATRVADIVADAVGLAEIEVRK--RRIRIVTDMRSRLPVIYVDPVLIEQVLVNLLKNGAEA 719
Cdd:PRK13557 216 AATLTQQLLAFARK---QRLEGRVLNLNGLVSGMGELAERTlgDAVTIETDLAPDLWNCRIDPTQAEVALLNVLINARDA 292
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 703205144 720 MAEARpnavdpviRVVVR----------------LESG-FVCISVVDQGPGVDEATAERLFEPFYSTKSDGMGMGL 778
Cdd:PRK13557 293 MPEGG--------RVTIRtrnveiededlamyhgLPPGrYVSIAVTDTGSGMPPEILARVMDPFFTTKEEGKGTGL 360
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
705-814 |
7.21e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 65.59 E-value: 7.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 705 IEQVLVNLLKNgaeamaearpnAV------DPVIRVVVRLESGF---VCISVVDQGPGVDEATAERLFEPF------YST 769
Cdd:cd16922 1 LRQILLNLLGN-----------AIkfteegEVTLRVSLEEEEEDgvqLRFSVEDTGIGIPEEQQARLFEPFsqadssTTR 69
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 703205144 770 KSDGMGMGLNICRSIIESHRGRLWVVNNVESdghitGATFHCSLP 814
Cdd:cd16922 70 KYGGTGLGLAISKKLVELMGGDISVESEPGQ-----GSTFTFTLP 109
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
707-814 |
1.66e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 64.52 E-value: 1.66e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 707 QVLVNLLKNgaeamaeARPNAVDPVIRVVVRL--ESGFVCISVVDQGPGVDEATAERLFEPFYSTKSDG------MGMGL 778
Cdd:cd16953 3 QVLRNLIGN-------AISFSPPDTGRITVSAmpTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANeafgqhSGLGL 75
|
90 100 110
....*....|....*....|....*....|....*.
gi 703205144 779 NICRSIIESHRGRLwVVNNVESDGHITGATFHCSLP 814
Cdd:cd16953 76 SISRQIIEAHGGIS-VAENHNQPGQVIGARFTVQLP 110
|
|
| PAS_4 |
pfam08448 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
335-438 |
1.87e-12 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 64.36 E-value: 1.87e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 335 VLDMHGRITHVNPAFCRMTGWDESDLVGKTaPFAYWPRDAYPEMQRQLDMTLRGKAPSSGFELRVRrkDGSTFHARLYVS 414
Cdd:pfam08448 10 VLDPDGRVRYANAAAAELFGLPPEELLGKT-LAELLPPEDAARLERALRRALEGEEPIDFLEELLL--NGEERHYELRLT 86
|
90 100
....*....|....*....|....
gi 703205144 415 PLIDSSGRQTGWMSSMTDITEPKR 438
Cdd:pfam08448 87 PLRDPDGEVIGVLVISRDITERRR 110
|
|
| PRK13560 |
PRK13560 |
hypothetical protein; Provisional |
305-447 |
2.25e-12 |
|
hypothetical protein; Provisional
Pssm-ID: 106506 [Multi-domain] Cd Length: 807 Bit Score: 70.86 E-value: 2.25e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 305 TRQRFEAQQALYAEAFFRRAMEnSVLIGMRVLDMHGRITHV-NPAFCRMTGWDESDLVGKTAP--------------FAY 369
Cdd:PRK13560 318 SGRRAAERELLEKEDMLRAIIE-AAPIAAIGLDADGNICFVnNNAAERMLGWSAAEVMGKPLPgmdpelneefwcgdFQE 396
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 370 WPRDAYPEMQRQLDM--TLRGKAPSSGFELRVRRKDGSTFHARLYVSPLIDSSGRQTGWMSSMTDITEPKRAREELAAAH 447
Cdd:PRK13560 397 WYPDGRPMAFDACPMakTIKGGKIFDGQEVLIEREDDGPADCSAYAEPLHDADGNIIGAIALLVDITERKQVEEQLLLAN 476
|
|
| PRK13558 |
PRK13558 |
bacterio-opsin activator; Provisional |
331-541 |
2.83e-12 |
|
bacterio-opsin activator; Provisional
Pssm-ID: 237426 [Multi-domain] Cd Length: 665 Bit Score: 70.25 E-value: 2.83e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 331 IGMRVLDMHGR---ITHVNPAFCRMTGWDESDLVGKTAPFAYWPR---DAYPEMQRQLDmtlrGKAPSSgFELRVRRKDG 404
Cdd:PRK13558 159 VGITIADATLPdepLIYINDAFERITGYSPDEVLGRNCRFLQGEDtneERVAELREAID----EERPTS-VELRNYRKDG 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 405 STFHARLYVSPLIDSSGRQTGWMSSMTDITEPKRAREELAAAHERFTTVLESLDAavsvLAADEAELLfanryyrhlfgI 484
Cdd:PRK13558 234 STFWNQVDIAPIRDEDGTVTHYVGFQTDVTERKEAELALQRERRKLQRLLERVEG----LVNDVTSAL-----------V 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 485 RPDGHLEL---------AGGGFDSA-----QASSDSIDMVDTYAGL--------------PAA-ALTESTADAQEIYVQS 535
Cdd:PRK13558 299 RATDREEIeaavcdrvgAGGEYDGAwigeyDPTSGTITVAEAAGGCdgadgdvldlaaagPAAaALQSVVAETEAVESTD 378
|
....*.
gi 703205144 536 IQKWFE 541
Cdd:PRK13558 379 VDGVSG 384
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
701-796 |
8.68e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 62.48 E-value: 8.68e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 701 DPVLIEQVLVNLLKNgaeAMAEARPNAVdpvIRVVVRLESGFVCISVVDQGPGVDEATAERLFEPFYS-----TKSDGMG 775
Cdd:cd16945 1 DPFLLRQAINNLLDN---AIDFSPEGGL---IALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSlprphSGQKSTG 74
|
90 100
....*....|....*....|.
gi 703205144 776 MGLNICRSIIESHRGRLWVVN 796
Cdd:cd16945 75 LGLAFVQEVAQLHGGRITLRN 95
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
685-816 |
9.74e-12 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 68.09 E-value: 9.74e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 685 IRIVTDMRSRLPVIYVDPVLIEQVLVNLLKNgAEAMAEARpnavdpvIRVVVRLESGFVCISVVDQGPGVDEATAERLFE 764
Cdd:PRK10604 300 KTVRLDTPHQGDYGALDMRLMERVLDNLLNN-ALRYAHSR-------VRVSLLLDGNQACLIVEDDGPGIPPEERERVFE 371
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 703205144 765 PFY------STKSDGMGMGLNICRSIIESHRGRlwvVNNVESDghITGATFHCSLPIG 816
Cdd:PRK10604 372 PFVrldpsrDRATGGCGLGLAIVHSIALAMGGS---VNCDESE--LGGARFSFSWPVW 424
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
711-814 |
1.22e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 61.92 E-value: 1.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 711 NLLKNGAEAMAEA-RPNAVdpvIRVVVRLESGFVCISVVDQGPGVDEATAERLFEPFYSTKSDG-MGMGLNICRSIIESH 788
Cdd:cd16915 7 NLIDNALDALAATgAPNKQ---VEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGeRGIGLALVRQSVERL 83
|
90 100
....*....|....*....|....*.
gi 703205144 789 RGRLWVVNNVESdghitGATFHCSLP 814
Cdd:cd16915 84 GGSITVESEPGG-----GTTFSIRIP 104
|
|
| CHASE |
COG3452 |
Extracellular (periplasmic) sensor domain CHASE (specificity unknown) [Signal transduction ... |
27-786 |
7.48e-11 |
|
Extracellular (periplasmic) sensor domain CHASE (specificity unknown) [Signal transduction mechanisms];
Pssm-ID: 442675 [Multi-domain] Cd Length: 785 Bit Score: 66.10 E-value: 7.48e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 27 HHGPWWSNSYLLTPLLSILVFLVVMSLILWSLNRREQQQQEDTLYRNVAWAQQQIRLSMTGAQEQIQALARDLVA-GHAD 105
Cdd:COG3452 4 SALLLLRRRPLLLALLAFLLLLAVGAVLERLLREQEEQQLRAEVLQELSAIRARLEGELNARLSLLRGLAALVEAnPGIS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 106 PQSFQVSTTDIMQGHPEILYMNWYTSQQQpRWpstALPVFGQRLAKPNDTQMDEAVKAAFTEARSTRRQV-YSPLiydDL 184
Cdd:COG3452 84 QEEFERLARNLLEDYPGIRNIALAPDGVI-RY---VYPLAGNEAALGLDLRTDPEQRAAALRARESGQLVlAGPV---NL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 185 ---GNGYItLQTPVY---RDREFLGSIAAVFSVEGILKHDIPPELSAKYKISI--IDANNRELTTTSTRPRLPRDMFYDL 256
Cdd:COG3452 157 vqgGRGLI-GRLPVFldgGDDRFWGFVSAVIDLDRLLDSAGLDDAQDGYQIALrgRDGDGAEGEVFYGDAALFDQDPVTL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 257 PLDPPGQGVSVRVYAFPQMTNFTNNTLVWLVAGL--SCFVLWSLWSLWKHTRQRFEAQQALYAEAFFRRAMensvliGMR 334
Cdd:COG3452 236 EVNLPGGSWQLAAAPKGGWLASPRNALPLRLAGLliSLLLALLVYLLRQLLLLRLLLLLLRLELIAAALLL------LLL 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 335 VLDMHGRITHVNPAFCRMTGWDESDLVGKtapFAYWPRDAYPEMQRQLDmtlRGKAPSSGFELRVRRKDGSTFHARLYVS 414
Cdd:COG3452 310 ALDLLLELLLLLRLAEALLQERLRALALL---AALEDLLLLKFDRDLLD---LLLLLELEAILALLLLLRRLLRSREARG 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 415 PLIDSSGRQTGWMSSMTDITEPKRAREELAAAHERFTTVLESLDAAVSVLAADEAELLFANRYYRHLFGIRPDGHLELAG 494
Cdd:COG3452 384 GLGGDLVRVGGVIDGRVAVILIIEALELAEARLAALDQERDASDVALGAALVVLEALLIIALLRELALLAGALLARKSLL 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 495 GGFDSAQASSDSIDMVDTYAGLPAAALTESTADAQEIYVQSIQKWFEVRRQYIQWVDghlaQMQIATDITTRKQAQELSR 574
Cdd:COG3452 464 LALDLAAESERLRYLELLLGDALRERIRRALLRLQLLSLDLSALAAVLGAESLAGLL----ISVFIDARILEAERLELAL 539
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 575 QQDEKLQFTSRLMTMGEMASSLAHELNQPLAAINNYCSGTVALVKSGRTTPDNLLPVLEKTAQQAVRAGMIIKRIREFVK 654
Cdd:COG3452 540 VAGEVALEELLLRLLGEILLLRAELILALLDAKSGLSALELSGLLAGRAALDSLLLLLALALRQLDESALFILEELLLRL 619
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 655 RS--EPKRQATRVADIVADAVGLAEIEVRKRRIRIVTDMRSRLPVIYVDPVLIeQVLVNLLKNGAEAMAEARPNAVDPVI 732
Cdd:COG3452 620 IIdlRIERLLLLLLGGEILLGELALLLLLLVLIILILLSVEEAGLILALSLLL-ALLLLAILDAAVSLLATLLLLFQLLL 698
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....
gi 703205144 733 RVVVRLESGFVCISVVDQGPGVDEATAERLFEPFYSTKSDGMGMGLNICRSIIE 786
Cdd:COG3452 699 LLLIILEGLLAELVAEALRLALALAQLLLRLLLAELLQLLLLLLGLILLELLLR 752
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
701-792 |
7.96e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 59.78 E-value: 7.96e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 701 DPVLIEQVLVNLLKNGAeamaeaRPNAVDPVIRVVVRLESGFVCISVVDQGPGVDEATAERLFEPFYSTKSD------GM 774
Cdd:cd16946 1 DRDRLQQLFVNLLENSL------RYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSrnrasgGS 74
|
90
....*....|....*...
gi 703205144 775 GMGLNICRSIIESHRGRL 792
Cdd:cd16946 75 GLGLAICHNIALAHGGTI 92
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
672-822 |
1.17e-10 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 65.31 E-value: 1.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 672 AVGLAEIEVRKRRIRIVTDMRSRLPV-IYVDPVLIEQVLVNLLKNGAEAMAEArpnavdpVIRVVVRLESGFVCISVVDQ 750
Cdd:PRK11466 528 TLQLMSGRVKGRPIRLATDIADDLPTaLMGDPRRIRQVITNLLSNALRFTDEG-------SIVLRSRTDGEQWLVEVEDS 600
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 703205144 751 GPGVDEATAERLFEPFY--STKSDGMGMGLNICRSIIESHRGRLWVVNNVEsdghiTGATFHCSLPIGEPDGPS 822
Cdd:PRK11466 601 GCGIDPAKLAEIFQPFVqvSGKRGGTGLGLTISSRLAQAMGGELSATSTPE-----VGSCFCLRLPLRVATAPV 669
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
706-792 |
6.14e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 57.39 E-value: 6.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 706 EQVLVNLLKNGAEAMAEA-----------RPNAVDPVIRvvvRLESG-FVCISVVDQGPGVDEATAERLFEPFYSTK--S 771
Cdd:cd16919 2 ELAILNLAVNARDAMPEGgrltietsnqrVDADYALNYR---DLIPGnYVCLEVSDTGSGMPAEVLRRAFEPFFTTKevG 78
|
90 100
....*....|....*....|.
gi 703205144 772 DGMGMGLNICRSIIESHRGRL 792
Cdd:cd16919 79 KGTGLGLSMVYGFVKQSGGHL 99
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
705-814 |
3.65e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 54.74 E-value: 3.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 705 IEQVLVNLLKNgaeAMAEARPNavdpvIRVVVRLESGFVCISVVDQGPGVDEATAERLFEPF------YSTKSDGMGMGL 778
Cdd:cd16939 1 MARALDNLLRN---ALRYAHRT-----VRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFvrldpsRDRATGGFGLGL 72
|
90 100 110
....*....|....*....|....*....|....*.
gi 703205144 779 NICRSIIESHRGRlwvVNNVESDghITGATFHCSLP 814
Cdd:cd16939 73 AIVHRVALWHGGH---VECDDSE--LGGACFRLTWP 103
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
327-447 |
8.13e-09 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 58.63 E-value: 8.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 327 NSVLIGMRVLDMHGRITHVNPAFCRMTGWDESDLVGKTApfaywpRDAYPEmqRQLDMTLRGKAPSSGFELRVRRKdGST 406
Cdd:COG3829 18 DSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNV------TELIPN--SPLLEVLKTGKPVTGVIQKTGGK-GKT 88
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 703205144 407 FHARLYvsPLIDsSGRQTGWMSSMTDITEPKRAREELAAAH 447
Cdd:COG3829 89 VIVTAI--PIFE-DGEVIGAVETFRDITELKRLERKLREEE 126
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
708-814 |
9.18e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 53.54 E-value: 9.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 708 VLVNLLKNgaeAMAEARPNAVdpvIRVVVRLESGFVCISVVDQGPGVDEATAERLFEPFY----STKSDGMGMGLNICRS 783
Cdd:cd16923 4 VFSNLLSN---AIKYSPENTR---IYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYrgdnSRNTEGAGLGLSIAKA 77
|
90 100 110
....*....|....*....|....*....|.
gi 703205144 784 IIESHRGRLwvvnNVESDGHITgaTFHCSLP 814
Cdd:cd16923 78 IIELHGGSA----SAEYDDNHD--LFKVRLP 102
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
539-814 |
9.88e-09 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 59.18 E-value: 9.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 539 WFEVRR-QYIQWVDGHLAQMQIATDITTRKQAQE-LSRQQDEKLQFTSrlmtmgemasSLAHELNQPLaainnycSGTVA 616
Cdd:PRK11091 241 CFELRKvPFYDRVGKRHGLMGFGRDITERKRYQDaLEKASRDKTTFIS----------TISHELRTPL-------NGIVG 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 617 LVKSGRTTpdnllpvlEKTAQQ----------AVRAGMIIKRIREFVK----RSEPKRQATRVADIVADAVGLAEIEVRK 682
Cdd:PRK11091 304 LSRILLDT--------ELTAEQrkylktihvsAITLGNIFNDIIDMDKmerrKLQLDNQPIDFTDFLADLENLSGLQAEQ 375
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 683 RRIRIVTDMRSRLP-VIYVDPVLIEQVLVNLLKNGAEAMAEARpnavdpvIRVVVRLESG-FVCISVVDQGPGVDEATAE 760
Cdd:PRK11091 376 KGLRFDLEPLLPLPhKVITDGTRLRQILWNLISNAVKFTQQGG-------VTVRVRYEEGdMLTFEVEDSGIGIPEDELD 448
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 703205144 761 RLFEPFYSTKSD-------GMGMGLNICRSIIESHRGRLwvvnNVESD-GHitGATFHCSLP 814
Cdd:PRK11091 449 KIFAMYYQVKDShggkpatGTGIGLAVSKRLAQAMGGDI----TVTSEeGK--GSCFTLTIH 504
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
703-814 |
1.04e-08 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 58.77 E-value: 1.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 703 VLIeQVLVNLLKNGAEAMAEARPNAVDpvirVVVRLESGFVCISVVDQGPGVDEATAERLFEPFYSTKSDGMGMGLNICR 782
Cdd:PRK11086 433 ELI-TILGNLIENALEAVGGEEGGEIS----VSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYSTKGSNRGVGLYLVK 507
|
90 100 110
....*....|....*....|....*....|..
gi 703205144 783 SIIESHRGRLwvvnNVESDGHItGATFHCSLP 814
Cdd:PRK11086 508 QSVENLGGSI----AVESEPGV-GTQFFVQIP 534
|
|
| PRK13559 |
PRK13559 |
hypothetical protein; Provisional |
321-447 |
1.23e-08 |
|
hypothetical protein; Provisional
Pssm-ID: 237427 [Multi-domain] Cd Length: 361 Bit Score: 57.91 E-value: 1.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 321 FRRAMENSVLiGMRVLDMHGR---ITHVNPAFCRMTGWDESDLVGKTAPFAYWPRDAyPEMQRQLDMTLRGKAPSSgFEL 397
Cdd:PRK13559 45 FEQAMEQTRM-AMCITDPHQPdlpIVLANQAFLDLTGYAAEEVVGRNCRFLQGAATD-PIAVAKIRAAIAAEREIV-VEL 121
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 703205144 398 RVRRKDGSTFHARLYVSPLIDSSGRQTGWMSSMTDITEPKRAREELAAAH 447
Cdd:PRK13559 122 LNYRKDGEPFWNALHLGPVYGEDGRLLYFFGSQWDVTDIRAVRALEAHER 171
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
585-802 |
1.24e-08 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 57.67 E-value: 1.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 585 RLMTmgemaSSLAHELNQPLAAINNYcsgtvalvksgrttpdnlLPVLEKtaQQAVRAGMIIKRIREFVKRSEPKRQATR 664
Cdd:PRK10755 138 RLFT-----ADVAHELRTPLAGIRLH------------------LELLEK--QHHIDVAPLIARLDQMMHTVEQLLQLAR 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 665 VA-----------DIVADAVGLAEIEVR----KRRIRIVTDMRSRLPVIYVDPVLIEQVLVNLLKNGAeamaeaRPNAVD 729
Cdd:PRK10755 193 AGqsfssghyqtvKLLEDVILPSQDELSemleQRQQTLLLPESAADITVQGDATLLRLLLRNLVENAH------RYSPEG 266
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 703205144 730 PVIRVVVRLESGFVCISVVDQGPGVDEATAERLFEPF--YSTKSDGMGMGLNICRSIIESHRGRLWVVNNVESDG 802
Cdd:PRK10755 267 STITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFvrMDSRYGGIGLGLSIVSRITQLHHGQFFLQNRQERSG 341
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
319-387 |
1.39e-08 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 52.02 E-value: 1.39e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 703205144 319 AFFRRAMENSVlIGMRVLDMHGRITHVNPAFCRMTGWDESDLVGKTApFAYWPRDAYPEMQRQLDMTLR 387
Cdd:smart00091 1 ERLRAILESLP-DGIFVLDLDGRILYANPAAEELLGYSPEELIGKSL-LELIHPEDRERVQEALQRLLS 67
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
701-800 |
1.81e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 53.18 E-value: 1.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 701 DPVLIEQVLVNLLKNgaeAMAEARPNAvdpviRVVVRLESGFVC-ISVVDQGPGVDEATAERLFEPFY---STKSDGMGM 776
Cdd:cd16940 10 DALLLFLLLRNLVDN---AVRYSPQGS-----RVEIKLSADDGAvIRVEDNGPGIDEEELEALFERFYrsdGQNYGGSGL 81
|
90 100
....*....|....*....|....
gi 703205144 777 GLNICRSIIESHRGRLWVVNNVES 800
Cdd:cd16940 82 GLSIVKRIVELHGGQIFLGNAQGG 105
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
566-784 |
2.02e-08 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 58.11 E-value: 2.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 566 RKQAQELSRQQDEKLQftsrlMTMGEMASSLAHELNQPLAAInnycSGTVALVKSGRTTPDNLlpVLEKTAQQAVRAGM- 644
Cdd:PRK15347 380 RTQALAEAKQRAEQAN-----KRKSEHLTTISHEIRTPLNGV----LGALELLQNTPLTAEQM--DLADTARQCTLSLLa 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 645 IIKRIREFvKRSEPKR-----QATRVADIVADAVGLAEIEVRKRRIRIVTDMRSRLP-VIYVDPVLIEQVLVNLLKNGAE 718
Cdd:PRK15347 449 IINNLLDF-SRIESGQmtlslEETALLPLLDQAMLTIQGPAQSKSLTLRTFVGAHVPlYLHLDSLRLRQILVNLLGNAVK 527
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 703205144 719 AMAEARpnavdpvIRVVVRLESGFVCISVVDQGPGVDEATAERLFEPFY--STKSDGMGMGLNICRSI 784
Cdd:PRK15347 528 FTETGG-------IRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYqaDTHSQGTGLGLTIASSL 588
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
705-796 |
2.25e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 52.45 E-value: 2.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 705 IEQVLVNLLKNGAEAMAEArpnavdpvIRVVVRLESGFVCISVVDQGPGVDEATAERLFEPFY----STKSDGMGMGLNI 780
Cdd:cd16950 1 LKRVLSNLVDNALRYGGGW--------VEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYrgdnARGTSGTGLGLAI 72
|
90
....*....|....*.
gi 703205144 781 CRSIIESHRGRLWVVN 796
Cdd:cd16950 73 VQRISDAHGGSLTLAN 88
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
657-799 |
4.73e-08 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 56.46 E-value: 4.73e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 657 EPKRQATRVADIVADAVgLAEievRKRRIRIVTDMRSRLPVIYVDPVLIEQVLVNLLKNGAeamaeaRPNAVDpvirvvV 736
Cdd:PRK09467 288 EMPMEMADLNALLGEVI-AAE---SGYEREIETALQPGPIEVPMNPIAIKRALANLVVNAA------RYGNGW------I 351
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 703205144 737 RLESGF----VCISVVDQGPGVDEATAERLFEPFysTKSD------GMGMGLNICRSIIESHRGRLWVVNNVE 799
Cdd:PRK09467 352 KVSSGTegkrAWFQVEDDGPGIPPEQLKHLFQPF--TRGDsargssGTGLGLAIVKRIVDQHNGKVELGNSEE 422
|
|
| PRK13560 |
PRK13560 |
hypothetical protein; Provisional |
336-575 |
8.28e-08 |
|
hypothetical protein; Provisional
Pssm-ID: 106506 [Multi-domain] Cd Length: 807 Bit Score: 56.22 E-value: 8.28e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 336 LDMHGRITHVNPAFCRMTGWDESDLVGKT----APfaYWPRDAYPEmqrqLDMTLRGKAPSSGFELRVRRKDGSTFHA-- 409
Cdd:PRK13560 220 KDEDAKVFGCNDAACLACGFRREEIIGMSihdfAP--AQPADDYQE----ADAAKFDADGSQIIEAEFQNKDGRTRPVdv 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 410 RLYVSPLIDSSGRQTGWMSSMTDITEPKRAREELAAAHERFTTVLESLDAAVSVLAAD---------EAELLF----ANR 476
Cdd:PRK13560 294 IFNHAEFDDKENHCAGLVGAITDISGRRAAERELLEKEDMLRAIIEAAPIAAIGLDADgnicfvnnnAAERMLgwsaAEV 373
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 477 YYRHLFGIRPDGHLELAGGGF-----DSAQASSDSIDMVDTYAGlpaaaltESTADAQEIYVQSIQKWFEVRRQY---IQ 548
Cdd:PRK13560 374 MGKPLPGMDPELNEEFWCGDFqewypDGRPMAFDACPMAKTIKG-------GKIFDGQEVLIEREDDGPADCSAYaepLH 446
|
250 260
....*....|....*....|....*...
gi 703205144 549 WVDGHL-AQMQIATDITTRKQAQELSRQ 575
Cdd:PRK13560 447 DADGNIiGAIALLVDITERKQVEEQLLL 474
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
671-792 |
1.12e-07 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 55.02 E-value: 1.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 671 DAVGLAEIEV-------RKRRIRIVTDMRSRLPViYVDPVLIEQVLVNLLKNgaeamaEARPNAVDPVIRVVVRLESGFV 743
Cdd:PRK10549 313 DLVPLLEVAGgafrerfASRGLTLQLSLPDSATV-FGDPDRLMQLFNNLLEN------SLRYTDSGGSLHISAEQRDKTL 385
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 703205144 744 CISVVDQGPGVDEATAERLFEPFYSTK------SDGMGMGLNICRSIIESHRGRL 792
Cdd:PRK10549 386 RLTFADSAPGVSDEQLQKLFERFYRTEgsrnraSGGSGLGLAICLNIVEAHNGRI 440
|
|
| PAS_3 |
pfam08447 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
342-430 |
1.99e-07 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.
Pssm-ID: 430001 [Multi-domain] Cd Length: 89 Bit Score: 49.26 E-value: 1.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 342 ITHVNPAFCRMTGWDESDLVGKTAPFA--YWPRDAyPEMQRQLDMTLRGKAPSSGfELRVRRKDGSTFHARLYVSPLIDS 419
Cdd:pfam08447 1 IIYWSPRFEEILGYTPEELLGKGESWLdlVHPDDR-ERVREALWEALKGGEPYSG-EYRIRRKDGEYRWVEARARPIRDE 78
|
90
....*....|.
gi 703205144 420 SGRQTGWMSSM 430
Cdd:pfam08447 79 NGKPVRVIGVA 89
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
701-814 |
2.48e-07 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 49.80 E-value: 2.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 701 DPVLIEQVLVNLLKNGAEAMAEARpnavdpviRVVVRLE---SGFVCISVVDQGPGVDEATAERLFEPFY------STKS 771
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGG--------RIRCILEkfrLNRFLLTVSDSGPGIPPNLREEIFERFRqgdgssTRAH 72
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 703205144 772 DGMGMGLNICRSIIESHRGRLWVvnnveSDGHITGATFHCSLP 814
Cdd:cd16925 73 GGTGLGLSIVKEFVELHGGTVTV-----SDAPGGGALFQVELP 110
|
|
| PAC |
smart00086 |
Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); PAC motif ... |
395-435 |
5.30e-07 |
|
Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); PAC motif occurs C-terminal to a subset of all known PAS motifs. It is proposed to contribute to the PAS domain fold.
Pssm-ID: 197509 Cd Length: 43 Bit Score: 46.79 E-value: 5.30e-07
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 703205144 395 FELRVRRKDGSTFHARLYVSPLIDSSGRQTGWMSSMTDITE 435
Cdd:smart00086 2 VEYRLRRKDGSYIWVLVSASPIRDEDGEVEGILGVVRDITE 42
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
686-814 |
5.62e-07 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 50.66 E-value: 5.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 686 RIVTDMRSRL--PVIYV--------DPVLIEQV---LVNLLKN----GAEAMAEARPNAVDPV--IRVVVRLESGFVCIS 746
Cdd:cd16916 7 RLVRDLARELgkQVELVvegedtelDKSVLEKLadpLTHLLRNavdhGIEAPEERLAAGKPPEgtITLRAEHQGNQVVIE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 747 VVDQGPGVD---------------EATAERL---------FEPFYSTKSD-----GMGMGLNICRSIIESHRGRLwvvnN 797
Cdd:cd16916 87 VSDDGRGIDrekirekaierglitADEAATLsddevlnliFAPGFSTAEQvtdvsGRGVGMDVVKRSIESLGGTI----E 162
|
170
....*....|....*...
gi 703205144 798 VESD-GhiTGATFHCSLP 814
Cdd:cd16916 163 VESEpG--QGTTFTIRLP 178
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
699-817 |
6.71e-07 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 52.71 E-value: 6.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 699 YVDPVLIEQVLV-NLLKNGAEAMAEarpnavDPVIRVVVRLESGFVCISVVDQGPGVDEATAERLFEPFySTKSDGMGMG 777
Cdd:COG2972 334 LLIPKLILQPLVeNAIEHGIEPKEG------GGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-SSKGEGRGIG 406
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 703205144 778 LNICRSIIESHRGRLWVVNNVESDGHITGATFHcsLPIGE 817
Cdd:COG2972 407 LRNVRERLKLYYGEEYGLEIESEPGEGTTVTIR--IPLEE 444
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
645-785 |
9.85e-07 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 52.67 E-value: 9.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 645 IIKRIREFVK------RSEPKRQATR--VADIVADAVGLaeieVRKRRIRIVTDMRSRLPVIYV-DPVLIEQVLVNLLKN 715
Cdd:PRK10841 498 IISDILDFSKieseqlKIEPREFSPRevINHITANYLPL----VVKKRLGLYCFIEPDVPVALNgDPMRLQQVISNLLSN 573
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 703205144 716 gaeAMAEARPNAVdpVIRVVVRleSGFVCISVVDQGPGVDEATAERLFEPFY------STKSDGMGMGLNICRSII 785
Cdd:PRK10841 574 ---AIKFTDTGCI--VLHVRVD--GDYLSFRVRDTGVGIPAKEVVRLFDPFFqvgtgvQRNFQGTGLGLAICEKLI 642
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
658-800 |
9.91e-07 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 52.08 E-value: 9.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 658 PKRQATRVADIVADAVGLAEIEVRKRRIRIvtDMRSRLPVIYVDPVLIEQVLVNLLKNGAEAMAEARpnavdpviRVVVR 737
Cdd:PRK09835 331 PEKKMLDLADEVGKVFDFFEAWAEERGVEL--RFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGE--------AITVR 400
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 703205144 738 LE--SGFVCISVVDQGPGVDEATAERLFEPFYST------KSDGMGMGLNICRSIIESHRGRLWVVNNVES 800
Cdd:PRK09835 401 CQevDHQVQLVVENPGTPIAPEHLPRLFDRFYRVdpsrqrKGEGSGIGLAIVKSIVVAHKGTVAVTSDARG 471
|
|
| PAS_8 |
pfam13188 |
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ... |
319-359 |
1.08e-06 |
|
PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 46.77 E-value: 1.08e-06
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 703205144 319 AFFRRAMENSvLIGMRVLDMHGRITHVNPAFCRMTGWDESD 359
Cdd:pfam13188 1 ERLRALFESS-PDGILVLDEGGRIIYVNPAALELLGYELLG 40
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
732-809 |
3.24e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 47.24 E-value: 3.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 732 IRVVVRLESGFVCISVVDQGPGVDEATAERLFEpfYSTKSD----GMGMGLNICRSIIESHRGRLWVvnnveSDGHITGA 807
Cdd:cd16954 57 VEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQ--RGQRLDeqrpGQGLGLAIAKEIVEQYGGELSL-----SDSPLGGA 129
|
..
gi 703205144 808 TF 809
Cdd:cd16954 130 RF 131
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
745-793 |
5.90e-06 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 49.55 E-value: 5.90e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 703205144 745 ISVVDQGPGVDEATAERLFEPFYST------KSDGMGMGLNICRSIIESHRGRLW 793
Cdd:PRK09470 386 ITVDDDGPGVPEEEREQIFRPFYRVdeardrESGGTGLGLAIVENAIQQHRGWVK 440
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
697-815 |
1.03e-05 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 49.35 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 697 VIYVDPVLIEQVLVNLLKNGAEAMAEARPNAVDPVIRVvvRLESGFVCISVVDQGPGVDEATAERLFEPFYST----KSD 772
Cdd:PRK09959 821 LVKIDPQAFKQVLSNLLSNALKFTTEGAVKITTSLGHI--DDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTsagrQQT 898
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 703205144 773 GMGMGLNICRSIIESHRGRLwvvnNVESDGHItGATFHCSLPI 815
Cdd:PRK09959 899 GSGLGLMICKELIKNMQGDL----SLESHPGI-GTTFTITIPV 936
|
|
| HATPase_AgrC-ComD-like |
cd16935 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
711-792 |
1.09e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.
Pssm-ID: 340412 [Multi-domain] Cd Length: 134 Bit Score: 45.65 E-value: 1.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 711 NLLKNGAEAMAEARPNavDPVIRVVVRLESGFVCISVVDQGPGvdeaTAERLFEPFYSTKSD-GMGMGLNICRSIIESHR 789
Cdd:cd16935 43 NLLDNAIEACAKIDKE--NRFIHLKIRQKKGFLIISIENSYEG----ELKKKNGLFLSTKKDkNHGIGLKSIREIVKKYN 116
|
...
gi 703205144 790 GRL 792
Cdd:cd16935 117 GNL 119
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
586-654 |
2.68e-05 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 42.58 E-value: 2.68e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 703205144 586 LMTMGEMASSLAHELNQPLAAInnycSGTVALVKSGRTTPDNLLPVLEKTAQQAVRAGMIIKRIREFVK 654
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAI----RGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
589-658 |
2.92e-05 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 42.58 E-value: 2.92e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 589 MGEMASSLAHELNQPLAAInnycSGTVALVKSGRTTPDnLLPVLEKTAQQAVRAGMIIKRIREFVKRSEP 658
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAI----RGYLELLRDEKLDEE-QREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| PRK11359 |
PRK11359 |
cyclic-di-GMP phosphodiesterase; Provisional |
335-441 |
4.65e-05 |
|
cyclic-di-GMP phosphodiesterase; Provisional
Pssm-ID: 183097 [Multi-domain] Cd Length: 799 Bit Score: 47.07 E-value: 4.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 335 VLDMHGRITHVNPAFCRMTGWDESDLVGKTAP-FAYWPRDAYPEMQRqLDMTLRGKAPSSGfELRVRRKDGSTFHARLYV 413
Cdd:PRK11359 151 VLDPERRIVQCNRAFTEMFGYCISEASGMQPDtLLNIPEFPADNRIR-LQQLLWKTARDQD-EFLLLTRTGEKIWIKASI 228
|
90 100
....*....|....*....|....*...
gi 703205144 414 SPLIDSSGRQTGWMSSMTDITEPKRARE 441
Cdd:PRK11359 229 SPVYDVLAHLQNLVMTFSDITEERQIRQ 256
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
745-814 |
5.52e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 42.96 E-value: 5.52e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 703205144 745 ISVVDQGPGVDEATAERLFEPFY------STKSDGMGMGLNICRSIIESHRGRLwvvnNVESDGHiTGATFHCSLP 814
Cdd:cd16952 35 LSVEDTGPGIPPEHIPRLTERFYrvdierCRNTGGTGLGLAIVKHVMSRHDARL----LIASELG-KGSRFTCLFP 105
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
589-658 |
1.49e-04 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 40.63 E-value: 1.49e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 703205144 589 MGEMASSLAHELNQPLAAInnycSGTVALVKSGRTTPD--NLLPVLEKTAQQAVRagmIIKRIREFVKRSEP 658
Cdd:smart00388 2 KREFLANLSHELRTPLTAI----RGYLELLLDTELSEEqrEYLETILREAERLLR---LINDLLDLSRIEAG 66
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
723-795 |
6.30e-04 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 40.67 E-value: 6.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 723 ARPNAVDPVIRVVVRLESGFVCISVVDQGPGVDEATAERLFEPfystkSDGMGMGLNICRSI-----IESHRG--RLWVV 795
Cdd:COG2172 50 AYGGDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLPDPYST-----LAEGGRGLFLIRRLmdeveYESDPGgtTVRLV 124
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
697-794 |
6.48e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 40.57 E-value: 6.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 697 VIY--VDPVLIEQVLVNLLKNGAEAMAEARpnavdpVIRVVVRLESGFVCISVVDQGPGVDEATAERLFEPFYSTKSD-- 772
Cdd:cd16947 11 PIYanANTEALQRILKNLISNAIKYGSDGK------FLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSrn 84
|
90 100
....*....|....*....|....*.
gi 703205144 773 ----GMGMGLNICRSIIESHRGRLWV 794
Cdd:cd16947 85 sakqGNGLGLTITKRLAESMGGSIYV 110
|
|
| HATPase_PDK-like |
cd16929 |
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ... |
684-782 |
1.55e-03 |
|
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.
Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 40.02 E-value: 1.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 684 RIRIVTDMRSRLPVIyvdPVLIEQVLVNLLKNGAEAMAE--ARPNAVDPVIRVVVRLESGFVCISVVDQGPGVDEATAER 761
Cdd:cd16929 26 ELEIEGDPSIRFPYV---PSHLYYILFELLKNAMRATVEshGDDSDDLPPIKVTVAKGDEDLTIKISDRGGGIPREDLAR 102
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 703205144 762 LFEPFYSTKSD-------------------GMGMGLNICR 782
Cdd:cd16929 103 LFSYMYSTAPQpslddfsdlisgtqpsplaGFGYGLPMSR 142
|
|
| PAS_7 |
pfam12860 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
327-441 |
6.19e-03 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.
Pssm-ID: 432837 [Multi-domain] Cd Length: 115 Bit Score: 37.52 E-value: 6.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 327 NSVLIGMRVLDMHGRITHVNPAFCRMTGWDEsDLVGKTAPFA-----------YWPRDAYPEMQRQLDMTLRGKAPSsgF 395
Cdd:pfam12860 2 ENMSQGLSVFDADLRLVAWNRRYRELLDLPE-DLVQVGVPFEeiirynaergeYGPGDVEAHVRRRLAAARAGSPHY--F 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 703205144 396 ElrVRRKDGSTFHARLyvSPLIDSsgrqtGWMSSMTDITEPKRARE 441
Cdd:pfam12860 79 E--RERPDGRVIEIRG--NPLPDG-----GFVTTFTDITERRRAEE 115
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
701-805 |
7.41e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 37.06 E-value: 7.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703205144 701 DPVLIEQVLVNLLKNGAEAMAEARpnavdpVIRVVVRLESGFVCISVVDQGPGVDEATAERLFEPFY----STKSDG-MG 775
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGG------TVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYrddtSRRSGGhYG 74
|
90 100 110
....*....|....*....|....*....|
gi 703205144 776 MGLNICRSIIESHRGRLWVVNNVESDGHIT 805
Cdd:cd16975 75 MGLYIAKNLVEKHGGSLIIENSQKGGAEVT 104
|
|
| HATPase_SpoIIAB-like |
cd16942 |
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein ... |
719-787 |
8.04e-03 |
|
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of SpoIIAB, an anti sigma-F factor and a serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli where, early in sporulation, the cell divides into two unequal compartments: a larger mother cell and a smaller forespore. Sigma-F transcription factor is activated in the forespore directly after the asymmetric septum forms, and its spatial and temporal activation is required for sporulation. Free sigma-F can associate with the RNA polymerase core and activate transcription of the sigma-F regulon, its regulation may comprise a partner-switching mechanism involving SpoIIAB, SpoIIAA, and sigma-F as follows: SpoIIAB can form alternative complexes with either: i) sigma-F, holding it in an inactive form and preventing its association with RNA polymerase, or ii) unphosphorylated SpoIIAA and a nucleotide, either ATP or ADP. In the presence of ATP, SpoIIAB acts as a kinase to specifically phosphorylate a serine residue of SpoIIAA; this phosphorylated form has low affinity for SpoIIAB and dissociates, making SpoIIAB available to capture sigma-F. SpoIIAA may then be dephosphorylated by a SpoIIE serine phosphatase and be free to attack the SpoIIAB sigma-F complex to induce the release of sigma-F.
Pssm-ID: 340418 [Multi-domain] Cd Length: 135 Bit Score: 37.52 E-value: 8.04e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 703205144 719 AMAEARPNAV------DP--VIRVVVRLESGFVCISVVDQGPGVDEATAERlfEPFYSTKS--DGMGMGLNICRSIIES 787
Cdd:cd16942 42 VVSEAVTNAIihgynnDPngIVSISVIIEDGVVHLTVRDEGVGIPDIEEAR--QPLFTTKPelERSGMGFTIMENFMDE 118
|
|
| |
