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penicillin-binding protein 2 [Helicobacter pylori]
Protein Classification
peptidoglycan D,D-transpeptidase FtsI family protein ( domain architecture ID 11433609 )
peptidoglycan D,D-transpeptidase FtsI (penicillin-binding protein (PBP) 2) family protein is a membrane-associated enzyme that is most likely involved in the synthesis of cross-linked peptidoglycan
List of domain hits
Name
Accession
Description
Interval
E-value
FtsI
COG0768 Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
63-594
4.86e-120
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440531 [Multi-domain]
Cd Length: 568
Bit Score: 367.61
E-value: 4.86e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 63 A T RG T IY SQDNYS LAT SQTLFK L GF D TRFLNPDK E D ff IDF L SIYSNIPKKS L KDAINT K G -- YII L AYD L T P NM AA N IR 140
Cdd:COG0768 59 A P RG L IY DRNGNV LAT NVPVYS L YA D PEEVKDPE E T -- AEK L AKLLGLDPEE L RKKLKK K S rf PVY L KRN L S P EE AA R IR 136
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 141 D L N kkflafgvfqn FK dahdkvwqkq G LNI E VSGV s R H YPY QNSLEPII GYV QKQEEDKLT ltt GK K G V EK SQDH LL KAQ 220
Cdd:COG0768 137 A L K ----------- LP ---------- G VYV E AEYK - R Y YPY GELAAHVL GYV GEINGGDGI --- GK S G L EK AYED LL RGT 191
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 221 q N G IKTGKR D VSFNF I QN h SYT E VERLD G YEVY L SVPLK LQ REI E TL L D K TKDKL KAK EIL V GIIN PK S GEIL SL AS SKR 300
Cdd:COG0768 192 - P G KRRVEV D ARGRV I RD - LGE E KPPVP G KDLV L TIDSD LQ KIA E EA L K K AVEEY KAK SGA V VVMD PK T GEIL AM AS YPS 269
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 301 F N PN AIKTSDY E S L - N LS V AE k VF EPGST I KP IVYSLL L DKNL I N P KERI D LN h GYY QL G KY TI K D DFIPSKKAV - VEDI 378
Cdd:COG0768 270 F D PN LFVGGPD E P L r N RA V QG - TY EPGST F KP FTAAAA L EEGV I T P DTTF D CP - GYY RV G GR TI R D WDRGGHGTL t LTEA 347
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 379 L IQ SSNVG MI K ISKN L NPEDF Y NG L LGY G FS QKTGIDL SL EA T G KI P PLSAF k REVLKGSV S Y G Y GL NA T F LQL LR AYA V 458
Cdd:COG0768 348 L AK SSNVG FY K LALR L GIDKL Y DY L KKF G LG QKTGIDL PG EA S G LL P SPKRW - YPGETATM S I G Q GL SV T P LQL AQ AYA A 426
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 459 FS N E G K L TT P Y LV QRETA P N G DIYIPS P KPTFQ VISP KS A RKMK E TLIK VV -- RY GT GKN A QFE G LYIG GKTGTA R V A -- 534
Cdd:COG0768 427 IA N G G V L VK P H LV KEIVD P D G EVVKEE P EVLRR VISP ET A ETVR E GMEG VV ne PG GT ARR A AIP G YRVA GKTGTA Q V V di 506
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727100697 535 K NG S Y SAESYNS SF F GFA -- EDE R qv FTIG VV I lg SHGKEEY Y ASKI AAP I F K EI T E ILV R Y 594
Cdd:COG0768 507 G NG G Y YKGRHIA SF V GFA pa DNP R -- YAVA VV V -- ENPGGGA Y GGTV AAP V F R EI M E AYL R L 564
Name
Accession
Description
Interval
E-value
FtsI
COG0768 Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
63-594
4.86e-120
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440531 [Multi-domain]
Cd Length: 568
Bit Score: 367.61
E-value: 4.86e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 63 A T RG T IY SQDNYS LAT SQTLFK L GF D TRFLNPDK E D ff IDF L SIYSNIPKKS L KDAINT K G -- YII L AYD L T P NM AA N IR 140
Cdd:COG0768 59 A P RG L IY DRNGNV LAT NVPVYS L YA D PEEVKDPE E T -- AEK L AKLLGLDPEE L RKKLKK K S rf PVY L KRN L S P EE AA R IR 136
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 141 D L N kkflafgvfqn FK dahdkvwqkq G LNI E VSGV s R H YPY QNSLEPII GYV QKQEEDKLT ltt GK K G V EK SQDH LL KAQ 220
Cdd:COG0768 137 A L K ----------- LP ---------- G VYV E AEYK - R Y YPY GELAAHVL GYV GEINGGDGI --- GK S G L EK AYED LL RGT 191
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 221 q N G IKTGKR D VSFNF I QN h SYT E VERLD G YEVY L SVPLK LQ REI E TL L D K TKDKL KAK EIL V GIIN PK S GEIL SL AS SKR 300
Cdd:COG0768 192 - P G KRRVEV D ARGRV I RD - LGE E KPPVP G KDLV L TIDSD LQ KIA E EA L K K AVEEY KAK SGA V VVMD PK T GEIL AM AS YPS 269
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 301 F N PN AIKTSDY E S L - N LS V AE k VF EPGST I KP IVYSLL L DKNL I N P KERI D LN h GYY QL G KY TI K D DFIPSKKAV - VEDI 378
Cdd:COG0768 270 F D PN LFVGGPD E P L r N RA V QG - TY EPGST F KP FTAAAA L EEGV I T P DTTF D CP - GYY RV G GR TI R D WDRGGHGTL t LTEA 347
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 379 L IQ SSNVG MI K ISKN L NPEDF Y NG L LGY G FS QKTGIDL SL EA T G KI P PLSAF k REVLKGSV S Y G Y GL NA T F LQL LR AYA V 458
Cdd:COG0768 348 L AK SSNVG FY K LALR L GIDKL Y DY L KKF G LG QKTGIDL PG EA S G LL P SPKRW - YPGETATM S I G Q GL SV T P LQL AQ AYA A 426
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 459 FS N E G K L TT P Y LV QRETA P N G DIYIPS P KPTFQ VISP KS A RKMK E TLIK VV -- RY GT GKN A QFE G LYIG GKTGTA R V A -- 534
Cdd:COG0768 427 IA N G G V L VK P H LV KEIVD P D G EVVKEE P EVLRR VISP ET A ETVR E GMEG VV ne PG GT ARR A AIP G YRVA GKTGTA Q V V di 506
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727100697 535 K NG S Y SAESYNS SF F GFA -- EDE R qv FTIG VV I lg SHGKEEY Y ASKI AAP I F K EI T E ILV R Y 594
Cdd:COG0768 507 G NG G Y YKGRHIA SF V GFA pa DNP R -- YAVA VV V -- ENPGGGA Y GGTV AAP V F R EI M E AYL R L 564
Transpeptidase
pfam00905 Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
282-589
1.52e-76
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.
Pssm-ID: 425939 [Multi-domain]
Cd Length: 296
Bit Score: 245.40
E-value: 1.52e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 282 VGIIN PK S GE I L SLASSKRFN PN AIKTS dyes L NLSVAEKVF EPGST I KP IVYSLL LD KNLIN P K E R I DLNH G YY Q ---- 357
Cdd:pfam00905 3 AVVLD PK T GE V L AMVGKPSYD PN GFIGP ---- L RNRAVTSRY EPGST F KP FTALAA LD NGVLK P D E T I FDWP G KQ Q ggks 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 358 L G KYTIKDDF I PS kkav VEDI L IQ SSN VG M I K ISKN L NPEDFYNG L LGY G FSQ KTGI D L SL E AT G KIP P lsafk REVLKG 437
Cdd:pfam00905 79 I G DWNQDQVG I GT ---- LRQA L EY SSN WY M Q K LAQK L GADKLRSY L KKF G YGN KTGI G L PG E NA G YLT P ----- YWLEGA 149
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 438 SV S Y G Y GL NA T F LQ LLR AYA VFS N E GKL TT P Y LV QRETA pngdi YIPSPKPTFQV IS PKS A R K M K ET L IK VV RY GTG KN - 516
Cdd:pfam00905 150 TA S F G I GL TI T P LQ QAQ AYA AIA N G GKL VP P H LV KSIED ----- KVDPKVLNKLP IS KST A E K V K DM L RL VV ND GTG TG t 224
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727100697 517 A QFE G LYIG GKTGTA R VA -- K N G S Y SAESYNSS F F G F A EDERQVFTIG V V I LGSHG kee YY AS K I AAPIFK E I T E 589
Cdd:pfam00905 225 A AVP G YKVA GKTGTA Q VA gp K G G G Y YDGAQIGW F V G Y A PADNPKYAFA V L I DDPKR --- YY GG K V AAPIFK D I L E 296
pbp2_mrdA
TIGR03423 penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
63-587
2.87e-61
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 274573 [Multi-domain]
Cd Length: 592
Bit Score: 213.92
E-value: 2.87e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 63 AT RG T I YSQDNYS LA TSQTL F K L gfdtr FLN P D K - E D F -- FI D F L SIYSNIP ---- KKS LK DAINTKGY -- I I L AY DLT P 133
Cdd:TIGR03423 48 PP RG L I LDRNGVL LA DNRPS F S L ----- EIV P E K v D D L da TL D R L AKLLDLD pedi ARF LK ELKRSRRF ep I P L KS DLT E 122
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 134 NMA A NIR dlnkkflafg V F Q N - FK dahdkvwqkq G LN IE V s GVS R H YPY QNSLEPII GYV QK - Q EED --------- KLTL 202
Cdd:TIGR03423 123 EEV A RFA ---------- V N Q Y r LP ---------- G VE IE A - RLK R Y YPY GELAAHVL GYV GE i N EED lerlepany AGGD 181
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 203 TT GK K G V EK SQDHL L KAQ q N G IKTGKRDVSFNF I QNH S YTEVER ld G YEVY L SVPLK LQ REI E TL L dkt KDKLK A keil V 282
Cdd:TIGR03423 182 YI GK S G I EK YYEDE L RGK - P G YREVEVNARGRV I RTL S RVPPVP -- G KDLV L TIDAR LQ QAA E KA L --- GGRRG A ---- V 251
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 283 GIIN P KS GEIL SLA S SKR F N PN A ---- I KTS DY ES L NLS -------- VAEK V FE PGST I KP I V YSLL L DKNL I N P KE RI D 350
Cdd:TIGR03423 252 VVMD P RT GEIL AMV S TPS F D PN L fvdg I SSK DY KA L LND pdrpllnr AIQG V YP PGST F KP V V ALAA L EEGV I T P ET RI Y 331
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 351 LN h GY Y QLG KYTIKDD fips K KAV ----- VEDILIQ S SN V GMIKISKN L NPEDFYNGLLGY GF S QKTGIDL SL E AT G KI P 425
Cdd:TIGR03423 332 CP - GY F QLG GRRFRCW ---- K RGG hgrvd LRKAIEE S CD V YFYQLALR L GIDKIAEYAKRF GF G QKTGIDL PG E KS G LV P 406
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 426 P l SAF KR EVLKG -------- S VS Y G Y G - LNA T F LQL LR A Y A VFS N E GKL TT P Y LV QRETA P N G DI -- YIPSPKPTFQV IS 494
Cdd:TIGR03423 407 S - REW KR KRFGQ pwypgdtl N VS I G Q G y VLV T P LQL AV A T A ALA N G GKL YK P H LV KSIED P D G GV vr RTEPEVLRPLP IS 485
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 495 P KSARKMK E TLIK VV -- RY GT GKN A QF - EGLYIG GKTGTA R V --- AKNGS Y S AE SY ------ NSS F FG FA EDERQVFTIG 562
Cdd:TIGR03423 486 P ENLDVVR E GMRD VV ng PG GT ARR A RL g LPYKMA GKTGTA Q V vsl KQGEK Y D AE QI perlrd HAL F VA FA PYDNPKIAVA 565
570 580
....*....|....*....|....*.
gi 727100697 563 V VI - L G SH G keeyya S KI AAPI FKE I 587
Cdd:TIGR03423 566 V IV e H G GG G ------ S SA AAPI ARK I 585
PRK15105
PRK15105 peptidoglycan synthase FtsI; Provisional
177-614
1.97e-29
peptidoglycan synthase FtsI; Provisional
Pssm-ID: 185060 [Multi-domain]
Cd Length: 578
Bit Score: 123.01
E-value: 1.97e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 177 R H YP YQNSLEPI IG YVQKQEE dkltltt G KK GVEKS Q D HL L KA Q Q n G IKTGKR D VSFNF I QNH S yt EVERLDGYEVY LS V 256
Cdd:PRK15105 166 R Y YP SGEVTAHL IG FTNVDSQ ------- G IE GVEKS F D KW L TG Q P - G ERIVRK D RYGRV I EDI S -- STDSQAAHNLA LS I 235
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 257 PLK LQ REIETL L DKTKDKL KA KEILVGIINPKS GE I L SL A S S KRF NPN AIKTSDYESLNLSVAEK VFEPGST I KP I V YSL 336
Cdd:PRK15105 236 DER LQ ALVYRE L NNAVAFN KA ESGSAVLVDVNT GE V L AM A N S PSY NPN NLSGTPKDAMRNRAITD VFEPGST V KP M V VMT 315
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 337 L L DKNLI np KE RID LN HGY Y QLGKYT IK d D FIPSKKAVVEDI L IQ SSNVG MI K ISKNLNPEDFYNGLLGY G FSQK T GID L 416
Cdd:PRK15105 316 A L QRGVV -- KE NSV LN TVP Y RINGHE IK - D VARYSELTLTGV L QK SSNVG VS K LALAMPSSALVDTYSRF G LGKA T NLG L 392
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 417 SL E AT G KI P PLSAFK r EVLKGSV S Y GYGL NA T F LQL L R A YA VFSNE G k LTT P YLVQRETA P ngdiy I P SPK p T F QVISPK 496
Cdd:PRK15105 393 VG E RS G LY P QKQRWS - DIERATF S F GYGL MV T P LQL A R V YA TIGSY G - IYR P LSITKVDP P ----- V P GER - V F PESIVR 464
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 497 SARK M K E TL ik VVRY G T G KN A QFE G LY I GG KTGTA R - V AKN G S Y s AES Y NSSFF G F A EDERQV F TI g VV ILGSHGKEE YY 575
Cdd:PRK15105 465 TVVH M M E SV -- ALPG G G G VK A AIK G YR I AI KTGTA K k V GPD G R Y - INK Y IAYTA G V A PASQPR F AL - VV VINDPQAGK YY 540
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 727100697 576 ASKIA AP I F KE I TEILV R YNYLS P siaiq N AL --- E KN R F K I 614
Cdd:PRK15105 541 GGAVS AP V F GA I MGGVL R TMNIE P ----- D AL ptg D KN E F V I 577
Name
Accession
Description
Interval
E-value
FtsI
COG0768 Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
63-594
4.86e-120
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440531 [Multi-domain]
Cd Length: 568
Bit Score: 367.61
E-value: 4.86e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 63 A T RG T IY SQDNYS LAT SQTLFK L GF D TRFLNPDK E D ff IDF L SIYSNIPKKS L KDAINT K G -- YII L AYD L T P NM AA N IR 140
Cdd:COG0768 59 A P RG L IY DRNGNV LAT NVPVYS L YA D PEEVKDPE E T -- AEK L AKLLGLDPEE L RKKLKK K S rf PVY L KRN L S P EE AA R IR 136
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 141 D L N kkflafgvfqn FK dahdkvwqkq G LNI E VSGV s R H YPY QNSLEPII GYV QKQEEDKLT ltt GK K G V EK SQDH LL KAQ 220
Cdd:COG0768 137 A L K ----------- LP ---------- G VYV E AEYK - R Y YPY GELAAHVL GYV GEINGGDGI --- GK S G L EK AYED LL RGT 191
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 221 q N G IKTGKR D VSFNF I QN h SYT E VERLD G YEVY L SVPLK LQ REI E TL L D K TKDKL KAK EIL V GIIN PK S GEIL SL AS SKR 300
Cdd:COG0768 192 - P G KRRVEV D ARGRV I RD - LGE E KPPVP G KDLV L TIDSD LQ KIA E EA L K K AVEEY KAK SGA V VVMD PK T GEIL AM AS YPS 269
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 301 F N PN AIKTSDY E S L - N LS V AE k VF EPGST I KP IVYSLL L DKNL I N P KERI D LN h GYY QL G KY TI K D DFIPSKKAV - VEDI 378
Cdd:COG0768 270 F D PN LFVGGPD E P L r N RA V QG - TY EPGST F KP FTAAAA L EEGV I T P DTTF D CP - GYY RV G GR TI R D WDRGGHGTL t LTEA 347
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 379 L IQ SSNVG MI K ISKN L NPEDF Y NG L LGY G FS QKTGIDL SL EA T G KI P PLSAF k REVLKGSV S Y G Y GL NA T F LQL LR AYA V 458
Cdd:COG0768 348 L AK SSNVG FY K LALR L GIDKL Y DY L KKF G LG QKTGIDL PG EA S G LL P SPKRW - YPGETATM S I G Q GL SV T P LQL AQ AYA A 426
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 459 FS N E G K L TT P Y LV QRETA P N G DIYIPS P KPTFQ VISP KS A RKMK E TLIK VV -- RY GT GKN A QFE G LYIG GKTGTA R V A -- 534
Cdd:COG0768 427 IA N G G V L VK P H LV KEIVD P D G EVVKEE P EVLRR VISP ET A ETVR E GMEG VV ne PG GT ARR A AIP G YRVA GKTGTA Q V V di 506
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727100697 535 K NG S Y SAESYNS SF F GFA -- EDE R qv FTIG VV I lg SHGKEEY Y ASKI AAP I F K EI T E ILV R Y 594
Cdd:COG0768 507 G NG G Y YKGRHIA SF V GFA pa DNP R -- YAVA VV V -- ENPGGGA Y GGTV AAP V F R EI M E AYL R L 564
Transpeptidase
pfam00905 Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
282-589
1.52e-76
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.
Pssm-ID: 425939 [Multi-domain]
Cd Length: 296
Bit Score: 245.40
E-value: 1.52e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 282 VGIIN PK S GE I L SLASSKRFN PN AIKTS dyes L NLSVAEKVF EPGST I KP IVYSLL LD KNLIN P K E R I DLNH G YY Q ---- 357
Cdd:pfam00905 3 AVVLD PK T GE V L AMVGKPSYD PN GFIGP ---- L RNRAVTSRY EPGST F KP FTALAA LD NGVLK P D E T I FDWP G KQ Q ggks 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 358 L G KYTIKDDF I PS kkav VEDI L IQ SSN VG M I K ISKN L NPEDFYNG L LGY G FSQ KTGI D L SL E AT G KIP P lsafk REVLKG 437
Cdd:pfam00905 79 I G DWNQDQVG I GT ---- LRQA L EY SSN WY M Q K LAQK L GADKLRSY L KKF G YGN KTGI G L PG E NA G YLT P ----- YWLEGA 149
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 438 SV S Y G Y GL NA T F LQ LLR AYA VFS N E GKL TT P Y LV QRETA pngdi YIPSPKPTFQV IS PKS A R K M K ET L IK VV RY GTG KN - 516
Cdd:pfam00905 150 TA S F G I GL TI T P LQ QAQ AYA AIA N G GKL VP P H LV KSIED ----- KVDPKVLNKLP IS KST A E K V K DM L RL VV ND GTG TG t 224
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727100697 517 A QFE G LYIG GKTGTA R VA -- K N G S Y SAESYNSS F F G F A EDERQVFTIG V V I LGSHG kee YY AS K I AAPIFK E I T E 589
Cdd:pfam00905 225 A AVP G YKVA GKTGTA Q VA gp K G G G Y YDGAQIGW F V G Y A PADNPKYAFA V L I DDPKR --- YY GG K V AAPIFK D I L E 296
pbp2_mrdA
TIGR03423 penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
63-587
2.87e-61
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 274573 [Multi-domain]
Cd Length: 592
Bit Score: 213.92
E-value: 2.87e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 63 AT RG T I YSQDNYS LA TSQTL F K L gfdtr FLN P D K - E D F -- FI D F L SIYSNIP ---- KKS LK DAINTKGY -- I I L AY DLT P 133
Cdd:TIGR03423 48 PP RG L I LDRNGVL LA DNRPS F S L ----- EIV P E K v D D L da TL D R L AKLLDLD pedi ARF LK ELKRSRRF ep I P L KS DLT E 122
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 134 NMA A NIR dlnkkflafg V F Q N - FK dahdkvwqkq G LN IE V s GVS R H YPY QNSLEPII GYV QK - Q EED --------- KLTL 202
Cdd:TIGR03423 123 EEV A RFA ---------- V N Q Y r LP ---------- G VE IE A - RLK R Y YPY GELAAHVL GYV GE i N EED lerlepany AGGD 181
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 203 TT GK K G V EK SQDHL L KAQ q N G IKTGKRDVSFNF I QNH S YTEVER ld G YEVY L SVPLK LQ REI E TL L dkt KDKLK A keil V 282
Cdd:TIGR03423 182 YI GK S G I EK YYEDE L RGK - P G YREVEVNARGRV I RTL S RVPPVP -- G KDLV L TIDAR LQ QAA E KA L --- GGRRG A ---- V 251
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 283 GIIN P KS GEIL SLA S SKR F N PN A ---- I KTS DY ES L NLS -------- VAEK V FE PGST I KP I V YSLL L DKNL I N P KE RI D 350
Cdd:TIGR03423 252 VVMD P RT GEIL AMV S TPS F D PN L fvdg I SSK DY KA L LND pdrpllnr AIQG V YP PGST F KP V V ALAA L EEGV I T P ET RI Y 331
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 351 LN h GY Y QLG KYTIKDD fips K KAV ----- VEDILIQ S SN V GMIKISKN L NPEDFYNGLLGY GF S QKTGIDL SL E AT G KI P 425
Cdd:TIGR03423 332 CP - GY F QLG GRRFRCW ---- K RGG hgrvd LRKAIEE S CD V YFYQLALR L GIDKIAEYAKRF GF G QKTGIDL PG E KS G LV P 406
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 426 P l SAF KR EVLKG -------- S VS Y G Y G - LNA T F LQL LR A Y A VFS N E GKL TT P Y LV QRETA P N G DI -- YIPSPKPTFQV IS 494
Cdd:TIGR03423 407 S - REW KR KRFGQ pwypgdtl N VS I G Q G y VLV T P LQL AV A T A ALA N G GKL YK P H LV KSIED P D G GV vr RTEPEVLRPLP IS 485
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 495 P KSARKMK E TLIK VV -- RY GT GKN A QF - EGLYIG GKTGTA R V --- AKNGS Y S AE SY ------ NSS F FG FA EDERQVFTIG 562
Cdd:TIGR03423 486 P ENLDVVR E GMRD VV ng PG GT ARR A RL g LPYKMA GKTGTA Q V vsl KQGEK Y D AE QI perlrd HAL F VA FA PYDNPKIAVA 565
570 580
....*....|....*....|....*.
gi 727100697 563 V VI - L G SH G keeyya S KI AAPI FKE I 587
Cdd:TIGR03423 566 V IV e H G GG G ------ S SA AAPI ARK I 585
MrcB
COG0744 Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall ...
248-587
4.32e-32
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440507 [Multi-domain]
Cd Length: 630
Bit Score: 131.58
E-value: 4.32e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 248 D G YEV Y LSVPL KLQ REI E TLLDKTKDKL K AKEILVGI -- IN PK S GE I L SLASSKRFN pnaiktsd YESL N LSVAE K v FE P 325
Cdd:COG0744 293 G G LKI Y TTLDP KLQ KAA E KAVKNVLPEG K PGGLQAAL vv VD PK T GE V L AMVGGRDYG -------- KSQF N RATQA K - RQ P 363
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 326 GST I KP I VY SLL L DKN l IN P KERI D LNHGYYQL G KYTI K DDFIPSKKA V - VEDI L IQ S S N VGMIKISKNLNPEDFYN gll 404
Cdd:COG0744 364 GST F KP F VY AAA L EQG - YT P ATTV D DEPVTFPG G GWSP K NYDGRYRGP V t LREA L AN S L N TPAVRLAQEVGLDKVVD --- 439
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 405 gyg FSQKT GI dlslea T GKIP P LSAF kre V L k G SVS ygygln ATF L QLLR AYA V F S N E G KLTT P YLVQRE T APN G D - I Y I 483
Cdd:COG0744 440 --- TARRL GI ------ T SPLD P NPSL --- A L - G TSE ------ VSP L EMAS AYA T F A N G G VYVE P HAITKV T DAD G K v L Y E 500
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 484 PS PK PT f QVISP KS A RK M KET L IK VV RY GTG KN A QFE G LYIG GKTGT arvakngsys AESYNSSF F - G FAED erqv FTIG 562
Cdd:COG0744 501 AK PK CE - QVISP EV A YL M TDM L QD VV TS GTG RA A RLP G RPVA GKTGT ---------- TNDNRDAW F v G YTPQ ---- LVTA 565
330 340
....*....|....*....|....*..
gi 727100697 563 V VILGSHGKEEY Y A -- SKIA API FKEI 587
Cdd:COG0744 566 V WVGNDDNSPMG Y V tg GSLP API WRDF 592
PRK15105
PRK15105 peptidoglycan synthase FtsI; Provisional
177-614
1.97e-29
peptidoglycan synthase FtsI; Provisional
Pssm-ID: 185060 [Multi-domain]
Cd Length: 578
Bit Score: 123.01
E-value: 1.97e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 177 R H YP YQNSLEPI IG YVQKQEE dkltltt G KK GVEKS Q D HL L KA Q Q n G IKTGKR D VSFNF I QNH S yt EVERLDGYEVY LS V 256
Cdd:PRK15105 166 R Y YP SGEVTAHL IG FTNVDSQ ------- G IE GVEKS F D KW L TG Q P - G ERIVRK D RYGRV I EDI S -- STDSQAAHNLA LS I 235
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 257 PLK LQ REIETL L DKTKDKL KA KEILVGIINPKS GE I L SL A S S KRF NPN AIKTSDYESLNLSVAEK VFEPGST I KP I V YSL 336
Cdd:PRK15105 236 DER LQ ALVYRE L NNAVAFN KA ESGSAVLVDVNT GE V L AM A N S PSY NPN NLSGTPKDAMRNRAITD VFEPGST V KP M V VMT 315
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 337 L L DKNLI np KE RID LN HGY Y QLGKYT IK d D FIPSKKAVVEDI L IQ SSNVG MI K ISKNLNPEDFYNGLLGY G FSQK T GID L 416
Cdd:PRK15105 316 A L QRGVV -- KE NSV LN TVP Y RINGHE IK - D VARYSELTLTGV L QK SSNVG VS K LALAMPSSALVDTYSRF G LGKA T NLG L 392
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 417 SL E AT G KI P PLSAFK r EVLKGSV S Y GYGL NA T F LQL L R A YA VFSNE G k LTT P YLVQRETA P ngdiy I P SPK p T F QVISPK 496
Cdd:PRK15105 393 VG E RS G LY P QKQRWS - DIERATF S F GYGL MV T P LQL A R V YA TIGSY G - IYR P LSITKVDP P ----- V P GER - V F PESIVR 464
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 497 SARK M K E TL ik VVRY G T G KN A QFE G LY I GG KTGTA R - V AKN G S Y s AES Y NSSFF G F A EDERQV F TI g VV ILGSHGKEE YY 575
Cdd:PRK15105 465 TVVH M M E SV -- ALPG G G G VK A AIK G YR I AI KTGTA K k V GPD G R Y - INK Y IAYTA G V A PASQPR F AL - VV VINDPQAGK YY 540
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 727100697 576 ASKIA AP I F KE I TEILV R YNYLS P siaiq N AL --- E KN R F K I 614
Cdd:PRK15105 541 GGAVS AP V F GA I MGGVL R TMNIE P ----- D AL ptg D KN E F V I 577
PRK10795
PRK10795 penicillin-binding protein 2; Provisional
64-547
9.84e-25
penicillin-binding protein 2; Provisional
Pssm-ID: 236761 [Multi-domain]
Cd Length: 634
Bit Score: 109.09
E-value: 9.84e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 64 T RG T IY SQDNYS LA TSQ T LFK L G fdtrf LN P D K E D ffidflsiysnipkk S L KDAINTKGYII lay DLT PNMA A NI --- R 140
Cdd:PRK10795 68 S RG I IY DRNGTP LA LNR T IYQ L E ----- MM P E K V D --------------- N L QQTLDALRSVV --- DLT DDDI A AF rke R 124
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 141 DLNKK F LAFG V FQ N FKD --- A HDK V W Q KQGLNI EV S G VS - R H YPY QNS L EPI IGYV Q K --------- QE E D KL ----- T L 202
Cdd:PRK10795 125 ARSRR F TSIP V KT N LTE vqv A RFA V N Q YRFPGV EV K G YQ r R Y YPY GSA L THV IGYV S K indkdverl DK E G KL anyaa T H 204
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 203 TT GK K G V E KSQDHL L KA qqngi KTG KRD V SF N ----- FI Q N H syt E VERLD G YEV YL SVP LKLQ RE IETLL DKTKDK lka 277
Cdd:PRK10795 205 DI GK L G I E RYYEDV L HG ----- KTG YEE V EV N nrgrv IR Q L H --- E QPPQA G HDI YL TLD LKLQ QY IETLL AGSRAA --- 273
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 278 keil V GIIN P KS G E IL S L A S SKRFN PN ---- A I KTS DY ES L --------- N l SVAEK V FE P G ST I KP I V YSLL L DKNL I N 344
Cdd:PRK10795 274 ---- V VVTD P RT G G IL A L V S TPSYD PN lfvd G I SSK DY SG L lndpnrpli N - RATQG V YP P A ST V KP Y V AVSA L SAGV I T 348
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 345 PKERI d LNH G YY QL --------------- G KYTI kddfips K K AVV E diliq S SNVGMIKISKNLNPEDFYNGLLGY G FS 409
Cdd:PRK10795 349 RNTSL - FDP G WW QL pgsekryrdwkkwgh G RLNV ------- T K SLE E ----- S ADTFFYQVAYDMGIDRLSEWMGKF G YG 415
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 410 QK TGIDL SL E AT G KI P ---- PLSA FK REVLK G --- S V SY G Y G L - N AT FL Q LLR A YAVFS N E G KLTT P Y L VQ r E TA PN G DI 481
Cdd:PRK10795 416 HY TGIDL AE E RS G NM P trew KQKR FK KPWYQ G dti P V GI G Q G Y w T AT PI Q MSK A LMTLI N D G IVKV P H L LM - S TA ED G KQ 494
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727100697 482 YIPSPKPTFQ V ISPK S A -- RKM K ETLIK V VRY -- GT GKNAQFEGL Y - I GG K T GTA R V A kn G SYSA E S YN SS 547
Cdd:PRK10795 495 VPWVQPHEPP V GDIH S G yw EIA K DGMYG V ANR pn GT AHKYFASAP Y k I AA K S GTA Q V F -- G LKAN E T YN AH 563
MrcA
COG5009 Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
325-586
9.05e-17
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 444033 [Multi-domain]
Cd Length: 785
Bit Score: 84.06
E-value: 9.05e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 325 PGS TI KP I VY SLL LD KN ----- L IN -- P KERI D LNH G ------- Y Y ql GK Y tik DDFIPSKK A vvedi L IQ S S N VGMIK i 390
Cdd:COG5009 459 PGS SF KP F VY AAA LD NG ytpat I IN da P IVFD D GGG G gvwrpkn Y S -- GK F --- YGPTTLRE A ----- L EK S R N LVTVR - 527
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 391 sknlnpedfyng LL gygfs Q KT GID LSLE ------ ATG K I PP - LS A fkre V L k GS VS ygygln A T F L QLL RAYAVF S N E G 463
Cdd:COG5009 528 ------------ LL ----- Q DV GID YVID yaerfg IYS K L PP n LS L ---- A L - GS GE ------ V T P L EMA RAYAVF A N G G 579
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 464 KLTT PYL VQ R ETAP NG ---------------- DIYIPSPK P TF ----- QVI S P KS A RK M KET L IK VV RY GTG KN A QFE G L 522
Cdd:COG5009 580 YRVE PYL ID R IEDR NG kviyradparacedcd AAEWDGAE P RL pdpae QVI D P RT A YQ M TSM L RG VV QR GTG RR A RAL G R 659
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727100697 523 Y I G GKTGT A rvak N G S YS A esyns S F F GF AE D erqv FTI GV VI ------- LG SHG keey YASKI A A PI FKE 586
Cdd:COG5009 660 D I A GKTGT T ---- N D S KD A ----- W F V GF TP D ---- LVA GV WV gfddprs LG RGE ---- TGGRA A L PI WID 713
PBP_dimer
pfam03717 Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of ...
63-238
9.39e-13
Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of Class B High Molecular Weight Penicillin-Binding Proteins. Its function has not been precisely defined, but is strongly implicated in PBP polymerization. The domain forms a largely disordered 'sugar tongs' structure.
Pssm-ID: 427460 [Multi-domain]
Cd Length: 178
Bit Score: 66.96
E-value: 9.39e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 63 A T RG T IY SQDNYS LAT SQTLFK L GFDTRF L NPDKEDFFID ---- F LS I Y SNIPKKS L KDAI ---- NT K G Y -- IILAYD L T 132
Cdd:pfam03717 4 A P RG E IY DRNGVV LAT NKPVYS L TITPSK L KKADALKTAL klak L LS N Y EDLDDED L TERF lkmn SY K S Y yp VVIKKN L S 83
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727100697 133 PNMA A N I RDLNKKF lafgvfqnfkdahdkvwqk Q G LN IE VS g VS R H YPY QNSLEPII GYV QKQE E DK L ---------- TL 202
Cdd:pfam03717 84 EEEV A R I EENLLEL ------------------- P G VS IE TD - PV R Y YPY GELAAHLL GYV GEIT E EE L ekyldkgysr GD 143
170 180 190
....*....|....*....|....*....|....*.
gi 727100697 203 TT GK K G V EK SQDHL L KA q QN G IKTGKR D VSFNF I QN 238
Cdd:pfam03717 144 LV GK S G L EK QYESV L RG - KD G VRQVEV D ALGRV I RE 178
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
