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Conserved domains on  [gi|727165479|ref|WP_033636207|]
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MULTISPECIES: 4-hydroxybenzoate octaprenyltransferase [Serratia]

Protein Classification

UbiA prenyltransferase family protein( domain architecture ID 91)

UbiA prenyltransferase family protein, an aromatic prenyltransferase, plays an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PT_UbiA super family cl00337
UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA ...
 10-288 1.03e-100

UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


The actual alignment was detected with superfamily member TIGR01474:

Pssm-ID: 469727  Cd Length: 281  Bit Score: 296.15  E-value: 1.03e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479   10 WRAYSHLMRIDKPIGTLLLLWPTLWALWLA--GKGVPPLSILLVFVLGVFLMRAAGCVVNDYADRAVDGYVKRTAGRPMP 87
Cdd:TIGR01474   1 LLPYAKLMRADKPIGTLLLLWPCLWSLLLAaqAGGIPPLYLLGLFTVGAILMRGAGCVINDIWDRDFDPQVERTKSRPLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479   88 SGRVSAKEAKVLFVVLVLISFCLVLTLNAMTIWLSLAALALAWAYPFMKRVTNLPQFVLGAAFGWGIPMGYAAVSESLPL 167
Cdd:TIGR01474  81 SGAVSVRQAILFLLVQLLVALGVLLQLNPLTILLGVASLALVATYPFMKRITYWPQLVLGLAFGWGALMGWAAVTGDLST 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479  168 SCWLLLLANICWTVAYDTLYAMVDRDDDLKIGIKSTAILFGRYDKLIVGLLQFATLLLLVWVGYLAQLGGAFYWSLLLAG 247
Cdd:TIGR01474 161 AAWVLYLANILWTLGYDTIYAMQDKEDDIKIGVKSTALRFGDNTKPWLGGLYALMILLLALAGLIAGLGPVYYLGLAAAA 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 727165479  248 ALFIHQQKQIAGREREACFKAFLQNNYVGLVVFIGIALSYL 288
Cdd:TIGR01474 241 LLLIRQIATLDIRDPENCLKLFKANNYVGLLLFAGIALGWL 281
 
Name Accession Description Interval E-value
ubiA_proteo TIGR01474
4-hydroxybenzoate polyprenyl transferase, proteobacterial; This model represents a family of ...
 10-288 1.03e-100

4-hydroxybenzoate polyprenyl transferase, proteobacterial; This model represents a family of integral membrane proteins that condenses para-hydroxybenzoate with any of several polyprenyldiphosphates. Heterologous expression studies suggest that for, many but not all members, the activity seen (e.g. octaprenyltransferase in E. coli) reflects available host isoprenyl pools rather than enzyme specificity. A fairly deep split by both clustering (UPGMA) and phylogenetics (NJ tree) separates this group (mostly Proteobacterial and mitochondrial), with several characterized members, from another group (mostly archaeal and Gram-positive bacterial) lacking characterized members. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 130539  Cd Length: 281  Bit Score: 296.15  E-value: 1.03e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479   10 WRAYSHLMRIDKPIGTLLLLWPTLWALWLA--GKGVPPLSILLVFVLGVFLMRAAGCVVNDYADRAVDGYVKRTAGRPMP 87
Cdd:TIGR01474   1 LLPYAKLMRADKPIGTLLLLWPCLWSLLLAaqAGGIPPLYLLGLFTVGAILMRGAGCVINDIWDRDFDPQVERTKSRPLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479   88 SGRVSAKEAKVLFVVLVLISFCLVLTLNAMTIWLSLAALALAWAYPFMKRVTNLPQFVLGAAFGWGIPMGYAAVSESLPL 167
Cdd:TIGR01474  81 SGAVSVRQAILFLLVQLLVALGVLLQLNPLTILLGVASLALVATYPFMKRITYWPQLVLGLAFGWGALMGWAAVTGDLST 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479  168 SCWLLLLANICWTVAYDTLYAMVDRDDDLKIGIKSTAILFGRYDKLIVGLLQFATLLLLVWVGYLAQLGGAFYWSLLLAG 247
Cdd:TIGR01474 161 AAWVLYLANILWTLGYDTIYAMQDKEDDIKIGVKSTALRFGDNTKPWLGGLYALMILLLALAGLIAGLGPVYYLGLAAAA 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 727165479  248 ALFIHQQKQIAGREREACFKAFLQNNYVGLVVFIGIALSYL 288
Cdd:TIGR01474 241 LLLIRQIATLDIRDPENCLKLFKANNYVGLLLFAGIALGWL 281
PT_UbiA_COQ2 cd13959
4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known ...
 17-286 3.22e-93

4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known as Coq2, catalyzes the prenylation of p-hydroxybenzoate with an all-trans polyprenyl group, an important step in ubiquinone (CoQ) biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260122 [Multi-domain]  Cd Length: 272  Bit Score: 276.65  E-value: 3.22e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479  17 MRIDKPIGTLLLLWPTLWALWLAGKGVPP--LSILLVFVLGVFLMRAAGCVVNDYADRAVDGYVKRTAGRPMPSGRVSAK 94
Cdd:cd13959    1 MRLDKPIGTLLLLPPALWGLLLAAGGLPLplLKLLLLFLLGAFLMRSAGCTINDIADRDIDAKVPRTKNRPLASGAISVK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479  95 EAKVLFVVLVLISFCLVLTLNAMTIWLSLAALALAWAYPFMKRVTNLPQFVLGAAFGWGIPMGYAAVSESLPLSCWLLLL 174
Cdd:cd13959   81 EALLFLAVQLLLGLALLLQLNPLTILLSPIALLLVLIYPLMKRFTYWPQLVLGLAFGWGPLMGWAAVTGSLPLPALLLYL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479 175 ANICWTVAYDTLYAMVDRDDDLKIGIKSTAILFGRYDKLIVGLLQFATLLLLVWVGYLAQLGGAFYWSLLLAGALFIHQQ 254
Cdd:cd13959  161 AVIFWTAGYDTIYAHQDREDDRKIGVKSTAVLFGDRTKLILALLLHLFVALLLLAGGLAGLGWPYYLGLGAAAHLLWQEH 240

                        250       260       270
                 ....*....|....*....|....*....|..
gi 727165479 255 KQIAGREREACFKAFLQNNYVGLVVFIGIALS 286
Cdd:cd13959  241 RLDLPDPLRSCLAFFLSNGWVGLLLFAGLLLD 272
UbiA COG0382
4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate ...
 11-285 2.85e-75

4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate polyprenyltransferase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440151  Cd Length: 280  Bit Score: 231.27  E-value: 2.85e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479  11 RAYSHLMRIDKPIGTLLLLWPTLWALWLAGKGVPPLSILLVFVLGVFLMRAAGCVVNDYADRAVDGYVKRTAGRPMPSGR 90
Cdd:COG0382    1 RAYLRLLRLDRPIGILLLLWPTLWALFLAAGGLPDLLLLLLAVLGTVLMRSAGYVINDYFDREIDRINERKPNRPLASGR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479  91 VSAKEAKVLFVVLVLISFCLVLTLNAMTIWLSLAALALAWAYP-FMKRVTNLPQFVLGAAFGWGIPMGYAAVSESLPLSC 169
Cdd:COG0382   81 ISLREALLLAIVLLLLALALALLLNPLTFLLALAALALAWAYSlFLKRFTLLGNLVLGLLFGLGILMGFAAVTGSLPLSA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479 170 WLLLLANICWTVAYDTLYAMVDRDDDLKIGIKSTAILFGRYDKL-IVGLLQFATLLLLVWVGYLAQLGGAFYWSLLLAG- 247
Cdd:COG0382  161 WLLALAAFLWTLAYDTIYDLEDREGDRKIGIKTLAILFGVRDALiIAGVLYALAVLLLLLLGLLAGLGLLYLLGLLAALl 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 727165479 248 ALFIHQQKQIAGR--EREACFKAFLQNNYVGLVVFIGIAL 285
Cdd:COG0382  241 LLYLSQLWLLRPRkkDPARALKLFKLNMLLGLLLFLGIAL 280
PLN02809 PLN02809
4-hydroxybenzoate nonaprenyltransferase
 8-288 1.84e-54

4-hydroxybenzoate nonaprenyltransferase


Pssm-ID: 178405  Cd Length: 289  Bit Score: 178.35  E-value: 1.84e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479   8 SKWRAYSHLMRIDKPIGTLLLLWPTLWALWLAGK--GVPPLSILLVFVLGVFLMRAAGCVVNDYADRAVDGYVKRTAGRP 85
Cdd:PLN02809   4 PSLRPYAKLARLDKPIGTWLLAWPCMWSIALAAPpgSLPDLKMLALFGCGALLLRGAGCTINDLLDRDIDKKVERTKLRP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479  86 MPSGRVSAKEAKVLFVVLVLISFCLVLTLNAMTIWLSLAALALAWAYPFMKRVTNLPQFVLGAAFGWGIPMGYAAVSESL 165
Cdd:PLN02809  84 IASGALTPFQGVGFLGAQLLLGLGILLQLNNYSRILGASSLLLVFTYPLMKRFTFWPQAFLGLTFNWGALLGWAAVKGSL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479 166 PLSCWL-LLLANICWTVAYDTLYAMVDRDDDLKIGIKSTAILFGRYDKLIVGLLQFATLLLLVWVGYLAQLGGAFYWSLL 244
Cdd:PLN02809 164 DPAVVLpLYASGVCWTLVYDTIYAHQDKEDDLKVGVKSTALRFGDDTKLWLTGFGAASIGGLALSGYNAGLGWPYYAGLA 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 727165479 245 LAGALFIHQQKQIAGREREACFKAFLQNNYVGLVVFIGIALSYL 288
Cdd:PLN02809 244 AAAGHLAWQIQTVDLSSRADCNRKFVSNKWFGAIVFAGIVLGKL 287
UbiA pfam01040
UbiA prenyltransferase family;
39-270 7.24e-48

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 160.09  E-value: 7.24e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479   39 AGKGVPPLSILLVFVLGVFLMRAAGCVVNDYADRAVDGYVKRTAGRPMPSGRVSAKEAKVLFVVLVLISFCLVLTLNAMT 118
Cdd:pfam01040  12 AAGGVPDLLLLLLALLGTVLARAAANALNDYYDRDIDAIMPRTPNRPLPSGRISPREALIFALVLLALGLLLLLLLNPLT 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479  119 IWLSLAALALAWAYP-FMKRVTNLPQFVLGAAFGWGIPMGYAAVSESLPLSCWLLLLANICWTVAYDTLYAMVDRDDDLK 197
Cdd:pfam01040  92 ALLGLAALLLYVLYTlRLKRRTLLGQLVGGLAFGLPPLLGWAAVTGSLSPLALLLALALFLWTWAIALANDLRDREDDRK 171

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 727165479  198 IGIKSTAILFGRYDKLIVGLLQFATLLLLVWVGYLAQLGGAFYWSLLLAGALFI-HQQKQIAGREREACFKAFL 270
Cdd:pfam01040 172 AGIKTLPVVLGRKAARILLALLLAVALLLLLLLLLLLLGGLYLLLALLLAALALlYAARLLRLRDPKKDAKAFF 245
 
Name Accession Description Interval E-value
ubiA_proteo TIGR01474
4-hydroxybenzoate polyprenyl transferase, proteobacterial; This model represents a family of ...
 10-288 1.03e-100

4-hydroxybenzoate polyprenyl transferase, proteobacterial; This model represents a family of integral membrane proteins that condenses para-hydroxybenzoate with any of several polyprenyldiphosphates. Heterologous expression studies suggest that for, many but not all members, the activity seen (e.g. octaprenyltransferase in E. coli) reflects available host isoprenyl pools rather than enzyme specificity. A fairly deep split by both clustering (UPGMA) and phylogenetics (NJ tree) separates this group (mostly Proteobacterial and mitochondrial), with several characterized members, from another group (mostly archaeal and Gram-positive bacterial) lacking characterized members. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 130539  Cd Length: 281  Bit Score: 296.15  E-value: 1.03e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479   10 WRAYSHLMRIDKPIGTLLLLWPTLWALWLA--GKGVPPLSILLVFVLGVFLMRAAGCVVNDYADRAVDGYVKRTAGRPMP 87
Cdd:TIGR01474   1 LLPYAKLMRADKPIGTLLLLWPCLWSLLLAaqAGGIPPLYLLGLFTVGAILMRGAGCVINDIWDRDFDPQVERTKSRPLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479   88 SGRVSAKEAKVLFVVLVLISFCLVLTLNAMTIWLSLAALALAWAYPFMKRVTNLPQFVLGAAFGWGIPMGYAAVSESLPL 167
Cdd:TIGR01474  81 SGAVSVRQAILFLLVQLLVALGVLLQLNPLTILLGVASLALVATYPFMKRITYWPQLVLGLAFGWGALMGWAAVTGDLST 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479  168 SCWLLLLANICWTVAYDTLYAMVDRDDDLKIGIKSTAILFGRYDKLIVGLLQFATLLLLVWVGYLAQLGGAFYWSLLLAG 247
Cdd:TIGR01474 161 AAWVLYLANILWTLGYDTIYAMQDKEDDIKIGVKSTALRFGDNTKPWLGGLYALMILLLALAGLIAGLGPVYYLGLAAAA 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 727165479  248 ALFIHQQKQIAGREREACFKAFLQNNYVGLVVFIGIALSYL 288
Cdd:TIGR01474 241 LLLIRQIATLDIRDPENCLKLFKANNYVGLLLFAGIALGWL 281
PT_UbiA_COQ2 cd13959
4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known ...
 17-286 3.22e-93

4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known as Coq2, catalyzes the prenylation of p-hydroxybenzoate with an all-trans polyprenyl group, an important step in ubiquinone (CoQ) biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260122 [Multi-domain]  Cd Length: 272  Bit Score: 276.65  E-value: 3.22e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479  17 MRIDKPIGTLLLLWPTLWALWLAGKGVPP--LSILLVFVLGVFLMRAAGCVVNDYADRAVDGYVKRTAGRPMPSGRVSAK 94
Cdd:cd13959    1 MRLDKPIGTLLLLPPALWGLLLAAGGLPLplLKLLLLFLLGAFLMRSAGCTINDIADRDIDAKVPRTKNRPLASGAISVK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479  95 EAKVLFVVLVLISFCLVLTLNAMTIWLSLAALALAWAYPFMKRVTNLPQFVLGAAFGWGIPMGYAAVSESLPLSCWLLLL 174
Cdd:cd13959   81 EALLFLAVQLLLGLALLLQLNPLTILLSPIALLLVLIYPLMKRFTYWPQLVLGLAFGWGPLMGWAAVTGSLPLPALLLYL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479 175 ANICWTVAYDTLYAMVDRDDDLKIGIKSTAILFGRYDKLIVGLLQFATLLLLVWVGYLAQLGGAFYWSLLLAGALFIHQQ 254
Cdd:cd13959  161 AVIFWTAGYDTIYAHQDREDDRKIGVKSTAVLFGDRTKLILALLLHLFVALLLLAGGLAGLGWPYYLGLGAAAHLLWQEH 240

                        250       260       270
                 ....*....|....*....|....*....|..
gi 727165479 255 KQIAGREREACFKAFLQNNYVGLVVFIGIALS 286
Cdd:cd13959  241 RLDLPDPLRSCLAFFLSNGWVGLLLFAGLLLD 272
UbiA COG0382
4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate ...
 11-285 2.85e-75

4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate polyprenyltransferase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440151  Cd Length: 280  Bit Score: 231.27  E-value: 2.85e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479  11 RAYSHLMRIDKPIGTLLLLWPTLWALWLAGKGVPPLSILLVFVLGVFLMRAAGCVVNDYADRAVDGYVKRTAGRPMPSGR 90
Cdd:COG0382    1 RAYLRLLRLDRPIGILLLLWPTLWALFLAAGGLPDLLLLLLAVLGTVLMRSAGYVINDYFDREIDRINERKPNRPLASGR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479  91 VSAKEAKVLFVVLVLISFCLVLTLNAMTIWLSLAALALAWAYP-FMKRVTNLPQFVLGAAFGWGIPMGYAAVSESLPLSC 169
Cdd:COG0382   81 ISLREALLLAIVLLLLALALALLLNPLTFLLALAALALAWAYSlFLKRFTLLGNLVLGLLFGLGILMGFAAVTGSLPLSA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479 170 WLLLLANICWTVAYDTLYAMVDRDDDLKIGIKSTAILFGRYDKL-IVGLLQFATLLLLVWVGYLAQLGGAFYWSLLLAG- 247
Cdd:COG0382  161 WLLALAAFLWTLAYDTIYDLEDREGDRKIGIKTLAILFGVRDALiIAGVLYALAVLLLLLLGLLAGLGLLYLLGLLAALl 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 727165479 248 ALFIHQQKQIAGR--EREACFKAFLQNNYVGLVVFIGIAL 285
Cdd:COG0382  241 LLYLSQLWLLRPRkkDPARALKLFKLNMLLGLLLFLGIAL 280
PLN02809 PLN02809
4-hydroxybenzoate nonaprenyltransferase
 8-288 1.84e-54

4-hydroxybenzoate nonaprenyltransferase


Pssm-ID: 178405  Cd Length: 289  Bit Score: 178.35  E-value: 1.84e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479   8 SKWRAYSHLMRIDKPIGTLLLLWPTLWALWLAGK--GVPPLSILLVFVLGVFLMRAAGCVVNDYADRAVDGYVKRTAGRP 85
Cdd:PLN02809   4 PSLRPYAKLARLDKPIGTWLLAWPCMWSIALAAPpgSLPDLKMLALFGCGALLLRGAGCTINDLLDRDIDKKVERTKLRP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479  86 MPSGRVSAKEAKVLFVVLVLISFCLVLTLNAMTIWLSLAALALAWAYPFMKRVTNLPQFVLGAAFGWGIPMGYAAVSESL 165
Cdd:PLN02809  84 IASGALTPFQGVGFLGAQLLLGLGILLQLNNYSRILGASSLLLVFTYPLMKRFTFWPQAFLGLTFNWGALLGWAAVKGSL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479 166 PLSCWL-LLLANICWTVAYDTLYAMVDRDDDLKIGIKSTAILFGRYDKLIVGLLQFATLLLLVWVGYLAQLGGAFYWSLL 244
Cdd:PLN02809 164 DPAVVLpLYASGVCWTLVYDTIYAHQDKEDDLKVGVKSTALRFGDDTKLWLTGFGAASIGGLALSGYNAGLGWPYYAGLA 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 727165479 245 LAGALFIHQQKQIAGREREACFKAFLQNNYVGLVVFIGIALSYL 288
Cdd:PLN02809 244 AAAGHLAWQIQTVDLSSRADCNRKFVSNKWFGAIVFAGIVLGKL 287
UbiA pfam01040
UbiA prenyltransferase family;
39-270 7.24e-48

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 160.09  E-value: 7.24e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479   39 AGKGVPPLSILLVFVLGVFLMRAAGCVVNDYADRAVDGYVKRTAGRPMPSGRVSAKEAKVLFVVLVLISFCLVLTLNAMT 118
Cdd:pfam01040  12 AAGGVPDLLLLLLALLGTVLARAAANALNDYYDRDIDAIMPRTPNRPLPSGRISPREALIFALVLLALGLLLLLLLNPLT 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479  119 IWLSLAALALAWAYP-FMKRVTNLPQFVLGAAFGWGIPMGYAAVSESLPLSCWLLLLANICWTVAYDTLYAMVDRDDDLK 197
Cdd:pfam01040  92 ALLGLAALLLYVLYTlRLKRRTLLGQLVGGLAFGLPPLLGWAAVTGSLSPLALLLALALFLWTWAIALANDLRDREDDRK 171

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 727165479  198 IGIKSTAILFGRYDKLIVGLLQFATLLLLVWVGYLAQLGGAFYWSLLLAGALFI-HQQKQIAGREREACFKAFL 270
Cdd:pfam01040 172 AGIKTLPVVLGRKAARILLALLLAVALLLLLLLLLLLLGGLYLLLALLLAALALlYAARLLRLRDPKKDAKAFF 245
ubiA PRK12873
4-hydroxybenzoate polyprenyltransferase;
7-250 2.66e-32

4-hydroxybenzoate polyprenyltransferase;


Pssm-ID: 171787 [Multi-domain]  Cd Length: 294  Bit Score: 120.54  E-value: 2.66e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479   7 QSKWRAYSHLMRIDKPIGTLLLLWPTLWALWLAGKGVPPLSILLVFVLGVFLMRAAGCVVNDYADRAVDGYVKRTAGRPM 86
Cdd:PRK12873   4 SIKLSPWFELLRWNKPTGRLILLIPAGWSLWLTPSAPPSLLLLLLIILGGLAVSGAGCIANDLWDRRIDRKVERTKNRPL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479  87 PSGRVSAKEAKVLFVVLVLISFCLVLTLNA----MTIWLSLAALALAWAYPFMKRVTNLPQFVLgaAFGWG----IPMGY 158
Cdd:PRK12873  84 ARGKISLKTAYSLLIVLLLLSLFVVLSLPQpsrnLCLSLAFLALPPILIYPSAKRWFAYPQAIL--ALCWGfavlIPWAA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479 159 AAVSESLPLSCWLLLLANICWTVAYDTLYAMVDRDDDLKIGIKSTAILFGRYDKLIVGLLQFATLLLLVWVGYLAQLGGA 238
Cdd:PRK12873 162 AEGSLNGGWPLLFCWLATLLWTFGFDTVYAMADRRDDAKIGLNSSALSLGSNALKTVQICYFLTSIFLALAAFIAQVGFI 241

                        250
                 ....*....|..
gi 727165479 239 FYWSLLLAGALF 250
Cdd:PRK12873 242 FWPFWLIASIGM 253
ubiA PRK13106
prenyltransferase; Reviewed
 6-288 2.56e-24

prenyltransferase; Reviewed


Pssm-ID: 237283  Cd Length: 300  Bit Score: 99.42  E-value: 2.56e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479   6 TQSKWRAYSHLMRIDKpigTLLLLWPTLWALWLAGKGVPPLSILLVFVLGVFLMRAAGCVVNDYADRAVDGYVKRTAGRP 85
Cdd:PRK13106  11 TRSKFYIILRFLRIEQ---TFFSLPMAYLGAFVAIKGIPPISTLILIFLALFFLRTAGMTNDNLADLEIDAKNPRTKNRP 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479  86 MPSGRVSAKEAKVLFVVLVLISFCLVLTLNAMTIWLSLAALALAWAYPFMKRVTNLPQFVLG-----AAFGWGIP---MG 157
Cdd:PRK13106  88 LVTGAIKISEAKALITAGLILFFASAYLVNRWALLLSPIVALIAMSYPYMKRYTAFANYHLAsiqglAVFSGAVAvlgLY 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479 158 YAAVSESLPLSCWLLLLANICWTVAYDTLYAMVDRDDDLKIGIKSTAILFGRYDKLIVGLLQFATLLLLVWVGYLAQLGG 237
Cdd:PRK13106 168 ANSLIQVLLRVPWLFVIGTILWAAGFDLYNHIPDAEFDREMGLHSFAVVLGKWALTFAGLNQLFSVVLDLLGDLYYGLGP 247

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 727165479 238 AFYWSLLLAGALFIHQQKQIAGREREAcfKAFLQNNYVGLVVFIGIALSYL 288
Cdd:PRK13106 248 IAIAATILHGLIMAYAYYLASKKGDFG--RAFYYNIYSSIVLGLGIIIDVL 296
ubiA PRK12888
4-hydroxybenzoate octaprenyltransferase;
66-280 2.55e-17

4-hydroxybenzoate octaprenyltransferase;


Pssm-ID: 183814  Cd Length: 284  Bit Score: 79.76  E-value: 2.55e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479  66 VNDYADRAVDGYVKRTAGRPMPSGRVSAKEAKVLFVVLVLISFCLVLTLNAMTIWLSLAALALAWAYPFMKRVTNLPQFV 145
Cdd:PRK12888  58 ANRIIDREIDARNPRTAGRELVTGAVSVRTAWTGALVALAVFLGAAALLNPLCLALAPLAVAPLVVYPYAKRFTNFPHAI 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479 146 LGAAFGWGIPMGYAAVSESLPLSCWLLLLANICWTVAYDTLYAMVDRDDDLKIGIKSTAILFGRYDKLIVGLLQ-FATLL 224
Cdd:PRK12888 138 LGLAQAVGPVGAWIAVTGTWSWPAVLLGLAVGLWIGGFDLIYACQDAEVDRRIGVRSVPARFGVRAALWASRVAhVVTFA 217

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 727165479 225 LLVWVGYLAQLGGAFYWSLLLAGALFIHQQKQIAGREREACFKAFLQ-NNYVGLVVF 280
Cdd:PRK12888 218 LFVWFGLAVGFGALWWIGLAITAGAFAYEHAIVSPTDLSRVNRAFFTaNGFVGIALF 274
ubiA PRK12886
prenyltransferase; Reviewed
 39-285 3.17e-16

prenyltransferase; Reviewed


Pssm-ID: 237247  Cd Length: 291  Bit Score: 77.04  E-value: 3.17e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479  39 AGKGVPPLSILLVFVLGVFLMRAAGCVVNDYADRAVDGYVKRTAGRPMPSGRVSaKEAKVLFVVLVLISFCLV-LTLNAM 117
Cdd:PRK12886  34 AALGLPGASQLDWILMAMVGARTAAMGFNRLIDAEIDARNPRTAGRAIPAGLIS-KGSAILFIVLSSLLMLFAaWFLNPL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479 118 TIWLSLAALALAWAYPFMKRVTNLPQFVLGAAFGwGIPMG-YAAVSESLPLSCWLLLLANICWTVAYDTLYAMVDRDDDL 196
Cdd:PRK12886 113 CLYLSPPALFFLLLYSYCKRFTALAHVVLGFCLA-LAPLGaWIAIRGTIELPAILLGLAVLFWVAGFDILYALQDLEFDR 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479 197 KIGIKSTAILFGRYDKLIVGLLQ-FATLLLLVWVGYLAQLGGAFYWSLLLAGALFIHQQKQIAGREREACFKAFLQ-NNY 274
Cdd:PRK12886 192 KEGLHSIPAKLGVNGSLWIARVFhLLMIGFLFALGISAGLGPWFLAGLAVTGILLLYEHWLLRGGDLTRLDAAFFNmNGY 271

                        250
                 ....*....|.
gi 727165479 275 VGLVVFIGIAL 285
Cdd:PRK12886 272 ISVTLFAATLF 282
PT_UbiA cd13956
UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA ...
 42-286 6.12e-16

UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260119 [Multi-domain]  Cd Length: 271  Bit Score: 75.85  E-value: 6.12e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479  42 GVPPLSILLVFVLGVFLMRAAGCVVNDYADRAVDGyvKRTAGRPMPSGRVSAKEAKVLFVVLVLISFCLVLTLNAMTIWL 121
Cdd:cd13956   27 AGPLPALLLLALLAVFLGAGAGYALNDYTDRELDA--INKPDRPLPSGRLSPRQALAFAAALLLVGLALALALGPLALLL 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479 122 SLAALALAWAYPFM-KRVTNLPQFVLGAAFGWGIPMGYAAVSESLPLSCWLLLLANIC-WTVAYDTLYAMVDRDDDLKIG 199
Cdd:cd13956  105 LLAGLLLGLAYSLGlKRLKLGGWGVLGYATGLALLPGLGAVAAGGLVPLALLLALVFLlLGLGINLYNDLPDVEGDRAAG 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479 200 IKSTAILFG--RYDKLIVGLLQFATLLLLVWVGYLAQLGGAFYWSLLLAGALFIHQQKQIAGREREAcfKAFLQNNYVGL 277
Cdd:cd13956  185 IRTLPVRLGprRARRLAAGLLLAALILVVLLAVAGLLGPLALLALLAVALLALRARFARADRLPALP--RGFLLLAVYRL 262


                 ....*....
gi 727165479 278 VVFIGIALS 286
Cdd:cd13956  263 LLFAALLLA 271
PRK04375 PRK04375
protoheme IX farnesyltransferase; Provisional
 39-118 1.08e-12

protoheme IX farnesyltransferase; Provisional


Pssm-ID: 235293  Cd Length: 296  Bit Score: 66.70  E-value: 1.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479  39 AGKGVPPLSILLVFVLGVFLMRAAGCVVNDYADRAVDGYVKRTAGRPMPSGRVSAKEAKVLFVVLVLISF-CLVLTLNAM 117
Cdd:PRK04375  36 APPGVPPLLLLLLTLLGIALVAGAAGALNNYIDRDIDAKMERTKNRPLVTGRISPREALIFGLVLGVLGFlLLGLFVNPL 115


                 .
gi 727165479 118 T 118
Cdd:PRK04375 116 A 116
PT_UbiA_Cox10 cd13957
Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O ...
 39-162 2.40e-12

Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O synthase, heme A:farnesyltransferase, cytochrome c oxidase subunit X [Cox10]) converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of the heme B porphyrin ring with a hydroxyethyl farnesyl side group. It is localized at the mitochondrial inner membrane. Eukaryotic Cox10 is important for the maturation of the heme A prosthetic group of cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, that catalyzes the electron transfer from reduced cytochrome c to oxygen. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260120  Cd Length: 271  Bit Score: 65.54  E-value: 2.40e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479  39 AGKGVPPLSILLVFVLGVFLMRAAGCVVNDYADRAVDGYVKRTAGRPMPSGRVSAKEAKVLFVVLVLISFC-LVLTLNAM 117
Cdd:cd13957   23 APGGVPDLLLLLLTLLGTALVSASANALNQYIERDIDAKMKRTRNRPLPSGRISPKHALIFGLVLGILGLAlLALFVNPL 102

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 727165479 118 TIWLSLAALAL-AWAYPFMKRVTNLPQFVLGAAFGwGIP--MGYAAVS 162
Cdd:cd13957  103 TALLGLLGIFLyVFVYTPLKKRTTPLNTVIGGIAG-AIPplIGWAAAT 149
ubiA PRK12874
4-hydroxybenzoate polyprenyltransferase;
66-286 5.76e-10

4-hydroxybenzoate polyprenyltransferase;


Pssm-ID: 237242  Cd Length: 291  Bit Score: 58.86  E-value: 5.76e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479  66 VNDYADRAVDGYVKRTAGRPMPSGRVSAKeAKVLFVVLVLISFCLVLTL-NAMTIWLSLAALALAWAYPFMKRVTNLPQF 144
Cdd:PRK12874  66 FNRLVDRDIDKDNPRTANRPSVDGRISVK-SMVLFIVLNALIFIGVSYFiNPLAFKLSFPFLIVLGGYSYFKRFSSLAHL 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479 145 VLGAAFGWGIPMGYAAVSESLPLSCWLLLLANICWTVAYDTLYAMVDRDDDLKIGIKSTAILFGRyDKLIVGLLQFATLL 224
Cdd:PRK12874 145 VLGLSLGLAPIAGVVAVLGEIPLWSVFLALGVMFWVAGFDLLYSLQDMEFDKKRGLHSIPSKFGE-KATLFISRLFHLLA 223

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 727165479 225 LLVWVGYLAQLG-GAFYWSLLLAGALFIHQQKQIAGREREACFKAFLQ-NNYVGLVVFIGIALS 286
Cdd:PRK12874 224 VLFWLLFVWCAHlGLFAYLGVIVSALILLYEHYLVRKDFKKIDKAFFTlNGYLGIVFFIFIVLD 287
ubiA PRK12876
prenyltransferase; Reviewed
 46-281 6.53e-10

prenyltransferase; Reviewed


Pssm-ID: 237244  Cd Length: 300  Bit Score: 58.60  E-value: 6.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479  46 LSILLVFVLGVFLMRAAGCVVNDYADRAVDGYVKRTAGRPMPSGRVSAKEAkvlFVVLVLISFCLVLT---LNAMTIWLS 122
Cdd:PRK12876  46 IKTISLGGSAFFCARTVGIIVNQIIDCAIDKKNPRTSSRVLPAKLLSINFS---MLLLTLCSFLFLSLcwlLNPLCFSLA 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479 123 LAALALAWAYPFMKRVTNLPQFVLGAAFGWGIPMGYAAVSESLPLSCWLLLLANICWTV-----AYDTLYAMVDRDDDLK 197
Cdd:PRK12876 123 VLSTLLMIIYPYTKRVTFLCHWILGLVYYLAILMNFFAIIETPLSFSLFCMASLWGISFgmiiaANDIIYAIQDLEFDRK 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479 198 IGIKSTAILFGRYDKL-IVGLLQFATLLLLVWVGYLAQLGGAFYWSLLLAGALFIHQQKQIAGRER-----EACFkaFLQ 271
Cdd:PRK12876 203 EGLFSIPARFGEKKAIrIASANLIASAIAYLLIGYFVSNKKIFYLCSLVPLTVILKTIKHYSLIDKkkstlEQKF--FLG 280

                        250
                 ....*....|
gi 727165479 272 NNYVGLVVFI 281
Cdd:PRK12876 281 NIYLALSFFV 290
ubiA PRK12895
prenyltransferase; Reviewed
 39-286 1.40e-08

prenyltransferase; Reviewed


Pssm-ID: 237251  Cd Length: 286  Bit Score: 54.82  E-value: 1.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479  39 AGKGVPPLSILLVFVLGVfLMRAAGCVVNDYADRAVDGYVKRTAGRPMPSGRVSAKEAKVLFVVLVLISFCLVLTLNAMT 118
Cdd:PRK12895  30 AGHYIHPIKILLILIAAV-SARTSAMSINRIEGLRYDMINPRKKDWALVSGRIKMREAIAFTIIFIAIFEICTFLLNRLV 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479 119 IWLSLAALALAWAYPFMKRVTNLPQFVLGAAFGWGIPMGYAAVSES--LPLSCWLLLLANICWTVAYDTLYAMVDRDDDL 196
Cdd:PRK12895 109 FILSPIVIFLFIIDPFLKRYTAWRHIYMGSIIGLGVLAGYLAVIPAfpYNLLIYIIFISSSLWIAGFDIIYVIPDIEYDK 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479 197 KIGIKSTAILFGRYDKLIVGLLQFATLLLLVWVGYLAQLGGAFYWSLLLAGALFIHQQKQIAGREREACFKAFLQ-NNYV 275
Cdd:PRK12895 189 INGLKTIMNTYGIKNGLYISDIFHISSLILFWISGIYIRTLWYLAALIIIYTLVIYQHLIIDPRNPINKRMSFFNaNSFI 268

                        250
                 ....*....|.
gi 727165479 276 GLVVFIGIALS 286
Cdd:PRK12895 269 GFVFLIGIILS 279
ubiA PRK12884
prenyltransferase; Reviewed
 9-110 1.18e-07

prenyltransferase; Reviewed


Pssm-ID: 183812  Cd Length: 279  Bit Score: 51.88  E-value: 1.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479   9 KWRAYSHLMRIDKPIGtllLLWPTLWALWLAGKGVPPLSILLVFvLGVFLMRAAGCVVNDYADRAVDgYVKRTAgRPMPS 88
Cdd:PRK12884   3 KMKAYLELLRPEHGLM---AGIAVVLGAIIALGGLPLDEALLGF-LTAFFASGSANALNDYFDYEVD-RINRPD-RPIPS 76

                         90       100
                 ....*....|....*....|..
gi 727165479  89 GRVSAKEAKVLFVVLVLISFCL 110
Cdd:PRK12884  77 GRISRREALLLAILLFILGLIA 98
PT_UbiA_DGGGPS cd13961
Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Digeranylgeranylglyceryl phosphate ...
 48-115 6.35e-07

Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Digeranylgeranylglyceryl phosphate synthase (DGGGPS) transfers a geranylgeranyl group from geranylgeranyl diphosphate to (S)-3-O-geranylgeranylglyceryl phosphate to form (S)-2,3-di-O-geranylgeranylglyceryl phosphate, as part of the isoprenoid ether lipid biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260124  Cd Length: 270  Bit Score: 49.42  E-value: 6.35e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727165479  48 ILLVFVlgVFLMRAAGCVVNDYADRAVDgYVKRTaGRPMPSGRVSAKEAKVLFVVLVLISFCLVLTLN 115
Cdd:cd13961   38 LLLFLS--VFLIAAAGYIINDYFDVEID-RINKP-DRPIPSGRISRREALILSILLNALGLILAFLLS 101
ubiA PRK12882
prenyltransferase; Reviewed
 44-119 1.86e-06

prenyltransferase; Reviewed


Pssm-ID: 183811  Cd Length: 276  Bit Score: 48.05  E-value: 1.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479  44 PPLSILLVFVlgVFLMRAAGCVVNDYADRAVDGyVKRtAGRPMPSGRVSAKEAK----VLFVVLVLISFclVLTLNAMTI 119
Cdd:PRK12882  37 PSLTGLAFAA--VFLATGAGNAINDYFDREIDR-INR-PDRPIPSGAVSPRGALafsiLLFAAGVALAF--LLPPLCLAI 110
PRK09573 PRK09573
(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase; Reviewed
 45-115 2.96e-06

(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase; Reviewed


Pssm-ID: 181963  Cd Length: 279  Bit Score: 47.65  E-value: 2.96e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727165479  45 PLSILLVFvLGVFLMRAAGCVVNDYADRAVDGYVKrtAGRPMPSGRVSAKEAKVLFVVLVLISFCLVLTLN 115
Cdd:PRK09573  36 LKGIILAA-LVVFLVCAGGNVINDIYDIEIDKINK--PERPIPSGRISLKEAKIFSITLFIVGLILSIFIN 103
PT_UbiA_UBIAD1 cd13962
1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Human UBIAD1 is an enzyme involved in the ...
 42-286 7.21e-06

1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Human UBIAD1 is an enzyme involved in the synthesis of MK-4. Menaquinones (MKs, also called bacterial forms) are one of the two forms of natural vitamin K, the other being the plant form, phylloquinone (PK). All forms of vitamin K have a 2-methyl-1,4-naphthoquinone (menadione; K3) ring structure in common. At the 3-position of the ring, PK has a phytyl side chain while MKs have several repeating prenyl units. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260125  Cd Length: 283  Bit Score: 46.35  E-value: 7.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479  42 GVPPLSILLVFVLGVFLMRAAGCVVNDYAD--RAVDGYVKRTAGRPMPSGRVSAKEAK----VLFVVLVLISFCLVLTLN 115
Cdd:cd13962   28 GFFNWLLFLLALLAALLLQIGVNLANDYFDykKGTDTEPRSGPSRVLVSGLLSPRQVLraalVLLLLAALLGLYLVALGG 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479 116 AMTIWLSLAALALAWAY---PFMKRVTNLPQFVLGAAFGWGIPMG-YAAVSESLPLSCWLLLLANICWTVAydTLYA--M 189
Cdd:cd13962  108 WLLLLLGLLGILAGYFYtggPFPLSYRGLGELFVFLFFGLLAVLGtYYVQTGSLSWEVLLAALPLGLLIAA--ILLAnnI 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479 190 VDRDDDLKIGIKSTAILFGRydKLIVGLLQFATLLLLVWVGYLAQLGGAFYWSL--LLAGALFIHQQKQIAGREREACFK 267
Cdd:cd13962  186 RDIEADRAAGKRTLAVRLGR--KRARRLYAALLLLAYLLLLLLVLLGLLPLWSLlaLLSLPLAIKLLRRLLRKADKPLLL 263

                        250
                 ....*....|....*....
gi 727165479 268 AFLQNNyVGLVVFIGIALS 286
Cdd:cd13962  264 IALKLT-ALLTLLFGLLLA 281
PT_UbiA_chlorophyll cd13958
Bacteriochlorophyll/chlorophyll synthetase; Chlorophyll synthase catalyzes the last step of ...
 39-119 8.78e-06

Bacteriochlorophyll/chlorophyll synthetase; Chlorophyll synthase catalyzes the last step of chlorophyll (Chl) biosynthesis, the addition of the tetraprenyl (phytyl or geranylgeranyl) side chain. In plant chloroplast, the chlorophyll synthase is located in thylakoid membrane and has been shown to also have a regulatory or channeling function. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260121  Cd Length: 277  Bit Score: 46.07  E-value: 8.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479  39 AGKGVPPLSILLVFVLGVFLMRAAGC----VVNDYADRAVDGYVKRTagRPMPSGRVSAKEAKVLFVVLVLISFCLVLTL 114
Cdd:cd13958   24 SGAFQWSNWDVWLLLLGMLLAGPLLTgtsqTINDYYDREVDAINEPY--RPIPSGRISEREALWNIWVLLLLSLLVALFL 101


                 ....*
gi 727165479 115 NAMTI 119
Cdd:cd13958  102 DGPWV 106
PT_UbiA_2 cd13963
UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of ...
 46-115 2.77e-05

UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways. The function of this subgroup is unknown.


Pssm-ID: 260126  Cd Length: 278  Bit Score: 44.77  E-value: 2.77e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 727165479  46 LSILLVFVLgvFLMrAAGCV--VNDYADRAVDGY--VKRTagRPMPSGRVSAKEAKVLFVVLVLISFCLVLTLN 115
Cdd:cd13963   33 LAALLAFVA--FCL-AASAVyiLNDLLDLEADRLhpTKRN--RPIASGRLSIPAALALAVVLLLAGLALALLLS 101
ubiA PRK12871
prenyltransferase; Reviewed
 62-208 1.04e-04

prenyltransferase; Reviewed


Pssm-ID: 106000  Cd Length: 297  Bit Score: 42.88  E-value: 1.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479  62 AGCVVNDYADRAVDG---------YVKRTAGRPMPSGRVSAKEAKVLFVVLVLISFCLVLTL----NAMTIWLSLAALAL 128
Cdd:PRK12871  56 AGFVLNDYVDRKRDRldventltrYWRPFKERPIPSGKLSSKNAFALFILLAAVTSALILTLpypnSLYVFVIMLYSYGI 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479 129 AWAYPFMKRVTNLP--QFVLGAAFGWGIPMGYAAVSESLPLSCWLLLLAnICWTVAYDTLYAMVDRDDDLKIGIKSTAIL 206
Cdd:PRK12871 136 EAFYQVKKRNQKYPvaQLLGRTDFTLFPAAGYLCYGQPDMTALLYMVFF-YPWTMAHLGLNDFIDLENDRARGMKSIAVL 214


                 ..
gi 727165479 207 FG 208
Cdd:PRK12871 215 YG 216
PT_UbiA_1 cd13964
UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of ...
 42-108 2.00e-04

UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways. The function of this subgroup is unknown.


Pssm-ID: 260127  Cd Length: 282  Bit Score: 42.18  E-value: 2.00e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727165479  42 GVPPLSILLVFVLGVFLMrAAGCVVNDYADRAVDGyVKRtAGRPMPSGRVSAKEAKV----LFVVLVLISF 108
Cdd:cd13964   28 LGPVLRLALLLLASVLLY-AAGMVLNDVFDAELDA-RER-PERPIPSGRVSRGAALAlgagLLAAGVALAA 95
PLN02776 PLN02776
prenyltransferase
 53-162 3.50e-04

prenyltransferase


Pssm-ID: 215415  Cd Length: 341  Bit Score: 41.65  E-value: 3.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727165479  53 VLGVFLMRAAGCVVNDYADRAVDGYVKRTAGRPMPSGRVSAKEAkVLFVVLVLISFCLVLTL--NAMTIWLSLA-ALALA 129
Cdd:PLN02776  35 CAGTMLCAASANTLNQVFEVKNDSKMKRTMRRPLPSGRISVPHA-VAWAVVVGAAGVALLAYktNMLTAGLGAGnILLYA 113

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 727165479 130 WAYPFMKRVTNLPQFVlGAAFGwGIP--MGYAAVS 162
Cdd:PLN02776 114 FVYTPLKQIHPANTWV-GAVVG-AIPplMGWAAAS 146
PRK12324 PRK12324
decaprenyl-phosphate phosphoribosyltransferase;
46-115 3.96e-04

decaprenyl-phosphate phosphoribosyltransferase;


Pssm-ID: 237058  Cd Length: 295  Bit Score: 41.39  E-value: 3.96e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 727165479  46 LSILLVFVLgvFLMrAAGCV--VNDYADRAVDGY--VKRTagRPMPSGRVSAKEAKVLFVVLVLISFCLVLTLN 115
Cdd:PRK12324  46 LKVLLAFVL--FCL-ASSAVylVNDIRDVEADRLhpTKRN--RPIASGVVSVSLAYILAVVLLVASLALAYLLS 114
PRK07566 PRK07566
chlorophyll synthase ChlG;
45-114 5.92e-04

chlorophyll synthase ChlG;


Pssm-ID: 236052  Cd Length: 314  Bit Score: 40.68  E-value: 5.92e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 727165479  45 PLSILLVFVLGVFL----MRAAGCVVNDYADRAVDGYvkRTAGRPMPSGRVSAKEAKVLFVVLVLISFCLVLTL 114
Cdd:PRK07566  59 TLENVLKLLAGMLLagplLCGTSQTLNDYFDREVDAI--NEPYRPIPSGAISLRWVLYLIAVLTVLGLAVAYLL 130
PRK12392 PRK12392
bacteriochlorophyll c synthase; Provisional
 66-110 3.83e-03

bacteriochlorophyll c synthase; Provisional


Pssm-ID: 171463  Cd Length: 331  Bit Score: 38.13  E-value: 3.83e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 727165479  66 VNDYADRAVDGYVKRTagRPMPSGRVSAKEAKVLFVVLVLISFCL 110
Cdd:PRK12392  69 VNDYFDLELDRVNEPT--RPIPSGRLSEKEALWNSIIVLLLAIGL 111
ubiA PRK12883
prenyltransferase UbiA-like protein; Reviewed
 39-115 7.24e-03

prenyltransferase UbiA-like protein; Reviewed


Pssm-ID: 171796  Cd Length: 277  Bit Score: 37.40  E-value: 7.24e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 727165479  39 AGKGVPPLSILLVFVLGVFLMRAAGCVVNDYADRAVDGyVKRtAGRPMPSGRVSAKEAKVLFVVLVLISFCLVLTLN 115
Cdd:PRK12883  29 ALGGIPPIKTLILIFLVVYLGCSGGNTINDYFDYEIDK-INR-PNRPLPRGAMSRKAALYYSLLLFAVGLALAYLIN 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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