|
Name |
Accession |
Description |
Interval |
E-value |
| murB |
PRK00046 |
UDP-N-acetylmuramate dehydrogenase; |
1-332 |
0e+00 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 234593 [Multi-domain] Cd Length: 334 Bit Score: 588.27 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 1 MSTESASLKNHNTFALPVNAAHLIMADRIELMLKVWQQTRKRQEPLLILGEGSNVLFLEDFSGTVMVNQLKGIDV-REDN 79
Cdd:PRK00046 2 QLQMNHSLKPLNTFGIDARARHLVEAESEEQLLEALADARAAGLPVLVLGGGSNVLFTEDFDGTVLLNRIKGIEVlSEDD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 80 DAWYLHVSSGENWHDLVQYTLQAGICGLENLALIPGLAGSAPIQNIGAYGVELKDVCEYVDLLDFSTGAIDRIPAAECGF 159
Cdd:PRK00046 82 DAWYLHVGAGENWHDLVLWTLQQGMPGLENLALIPGTVGAAPIQNIGAYGVELKDVCDYVEALDLATGEFVRLSAAECRF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 160 GYRESIFKHRFQTGHVIVGLGLRLNKQWQPKLSYGDLAKLDPATVTPLQVFESVCAMRRSKLPDPRETGNAGSFFKNPLV 239
Cdd:PRK00046 162 GYRDSIFKHEYPDRYAITAVGFRLPKQWQPVLDYGDLARLDPDTVTAQDVFDAVCAIRRSKLPDPKVLGNAGSFFKNPVV 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 240 NAEKAAELIAKYPGMPHYPQQDGQVKLAAGWLIDQCELKGYRIGGAAVHRQQALVLVNIDNAHSQDVVALARHVRKTVAD 319
Cdd:PRK00046 242 SAEQFEALLAQYPDIPHYPQADGSVKLAAGWLIDQCGLKGFQIGGAAVHEKQALVLVNYGNATGADVLALARHIQQDVRE 321
|
330
....*....|...
gi 727166623 320 KFGVWLEPEVRFI 332
Cdd:PRK00046 322 KFGVELEPEPRFI 334
|
|
| MurB |
COG0812 |
UDP-N-acetylenolpyruvoylglucosamine reductase [Cell wall/membrane/envelope biogenesis]; ... |
6-332 |
8.26e-129 |
|
UDP-N-acetylenolpyruvoylglucosamine reductase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylenolpyruvoylglucosamine reductase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440574 [Multi-domain] Cd Length: 279 Bit Score: 369.34 E-value: 8.26e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 6 ASLKNHNTFALPVNAAHLIMADRIELMLKVWQQTRKRQEPLLILGEGSNVLFLED-FSGTVMVN-QLKGIDVREDndaWY 83
Cdd:COG0812 1 EPLAPHTTFRIGGPADLLVEPASEEELAALLRAAREAGLPVLVLGGGSNLLVRDDgFDGLVIRLgRLKGIEVDDG---VL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 84 LHVSSGENWHDLVQYTLQAGICGLENLALIPGLAGSAPIQNIGAYGVELKDVCEYVDLLDfSTGAIDRIPAAECGFGYRE 163
Cdd:COG0812 78 VTAGAGENWHDLVRFALEAGLSGLEFLAGIPGTVGGAPVMNAGAYGGEIKDVLESVEVLD-RTGEVRTLSAEECGFGYRD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 164 SIFKHRfqtGHVIVGLGLRLNKQwqpklSYGDLAkldpatvtplQVFESVCAMRRSKlpDPRETGNAGSFFKNPlvnaek 243
Cdd:COG0812 157 SIFKRE---RYIILSVTFRLKKG-----DPAEIA----------AVMDAVLAIRRSK--QPLELPSAGSFFKNP------ 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 244 aaeliakyPGMPhypqqdgqvklaAGWLIDQCELKGYRIGGAAVHRQQALVLVNIDNAHSQDVVALARHVRKTVADKFGV 323
Cdd:COG0812 211 --------PGDS------------AGWLIEQAGLKGYRIGGAQVSEKHANFLVNRGGATAADVLALIEEVQARVKEKFGV 270
|
....*....
gi 727166623 324 WLEPEVRFI 332
Cdd:COG0812 271 ELEPEVRII 279
|
|
| murB |
TIGR00179 |
UDP-N-acetylenolpyruvoylglucosamine reductase; This model describes MurB, ... |
8-333 |
1.57e-118 |
|
UDP-N-acetylenolpyruvoylglucosamine reductase; This model describes MurB, UDP-N-acetylenolpyruvoylglucosamine reductase, which is also called UDP-N-acetylmuramate dehydrogenase. It is part of the pathway for the biosynthesis of the UDP-N-acetylmuramoyl-pentapeptide that is a precursor of bacterial peptidoglycan. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 272945 [Multi-domain] Cd Length: 284 Bit Score: 343.67 E-value: 1.57e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 8 LKNHNTFALPVNAAHLIMADRIELMLKVWQQTRKRQEPLLILGEGSNVLFLEDFSGTVMVNQLKGIDVREDnDAWYLHVS 87
Cdd:TIGR00179 1 LAEFTTYKIGGNARHIVCPESIEQLVNVLDNAKEEDQPLLILGEGSNLLILDDGRGGVIINLGKGIDIEDD-EGEYVHVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 88 SGENWHDLVQYTLQAGICGLENLALIPGLAGSAPIQNIGAYGVELKDVCEYVDLLdFSTGAIDRIPAAECGFGYRESIFK 167
Cdd:TIGR00179 80 GGENWHKLVKYALKNGLSGLEFLAGIPGTVGGAVIMNAGAYGVEISEVLVYATIL-LATGKTEWLTNEQLGFGYRTSIFQ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 168 HRFqtghvivgLGLRLNKQWQPKLSYGDlaKLDPATVTPLQVFESVCAMRRSKLPDPretgNAGSFFKNPLvnaekaael 247
Cdd:TIGR00179 159 HKY--------VGLVLKAEFQLTLGFGT--RLDPETITAQQVFNKVCRMRTSHYPDP----NAGSFFKNPS--------- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 248 iakypgmPHYpqqdgqvklaAGWLIDQCELKGYRIGGAAVHRQQALVLVNIDNAHSQDVVALARHVRKTVADKFGVWLEP 327
Cdd:TIGR00179 216 -------PNH----------AGRLIEECGLKGYQIGGAAVSKQHANFLVNIDNAKSEDVLDLIEHVKAEVGEKYGILLEP 278
|
....*.
gi 727166623 328 EVRFIG 333
Cdd:TIGR00179 279 EVKIIG 284
|
|
| MurB_C |
pfam02873 |
UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Members of this family are ... |
209-332 |
3.92e-46 |
|
UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Members of this family are UDP-N-acetylenolpyruvoylglucosamine reductase enzymes EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan.
Pssm-ID: 460730 [Multi-domain] Cd Length: 99 Bit Score: 152.12 E-value: 3.92e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 209 VFESVCAMRRSKL-PDPRETGNAGSFFKNPlvnaekaaeliakypgmphypqqdgqVKLAAGWLIDQCELKGYRIGGAAV 287
Cdd:pfam02873 1 IRAAMLELRRRRLaKQPLDPPSAGSFFKNP--------------------------VGHSAGWLIEQAGLKGYRIGGAQV 54
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 727166623 288 HRQQALVLVNIDNAHSQDVVALARHVRKTVADKFGVWLEPEVRFI 332
Cdd:pfam02873 55 SEKHANFLVNTGGATAADVLALIEEVRERVKEKFGVELEPEVRII 99
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| murB |
PRK00046 |
UDP-N-acetylmuramate dehydrogenase; |
1-332 |
0e+00 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 234593 [Multi-domain] Cd Length: 334 Bit Score: 588.27 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 1 MSTESASLKNHNTFALPVNAAHLIMADRIELMLKVWQQTRKRQEPLLILGEGSNVLFLEDFSGTVMVNQLKGIDV-REDN 79
Cdd:PRK00046 2 QLQMNHSLKPLNTFGIDARARHLVEAESEEQLLEALADARAAGLPVLVLGGGSNVLFTEDFDGTVLLNRIKGIEVlSEDD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 80 DAWYLHVSSGENWHDLVQYTLQAGICGLENLALIPGLAGSAPIQNIGAYGVELKDVCEYVDLLDFSTGAIDRIPAAECGF 159
Cdd:PRK00046 82 DAWYLHVGAGENWHDLVLWTLQQGMPGLENLALIPGTVGAAPIQNIGAYGVELKDVCDYVEALDLATGEFVRLSAAECRF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 160 GYRESIFKHRFQTGHVIVGLGLRLNKQWQPKLSYGDLAKLDPATVTPLQVFESVCAMRRSKLPDPRETGNAGSFFKNPLV 239
Cdd:PRK00046 162 GYRDSIFKHEYPDRYAITAVGFRLPKQWQPVLDYGDLARLDPDTVTAQDVFDAVCAIRRSKLPDPKVLGNAGSFFKNPVV 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 240 NAEKAAELIAKYPGMPHYPQQDGQVKLAAGWLIDQCELKGYRIGGAAVHRQQALVLVNIDNAHSQDVVALARHVRKTVAD 319
Cdd:PRK00046 242 SAEQFEALLAQYPDIPHYPQADGSVKLAAGWLIDQCGLKGFQIGGAAVHEKQALVLVNYGNATGADVLALARHIQQDVRE 321
|
330
....*....|...
gi 727166623 320 KFGVWLEPEVRFI 332
Cdd:PRK00046 322 KFGVELEPEPRFI 334
|
|
| MurB |
COG0812 |
UDP-N-acetylenolpyruvoylglucosamine reductase [Cell wall/membrane/envelope biogenesis]; ... |
6-332 |
8.26e-129 |
|
UDP-N-acetylenolpyruvoylglucosamine reductase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylenolpyruvoylglucosamine reductase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440574 [Multi-domain] Cd Length: 279 Bit Score: 369.34 E-value: 8.26e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 6 ASLKNHNTFALPVNAAHLIMADRIELMLKVWQQTRKRQEPLLILGEGSNVLFLED-FSGTVMVN-QLKGIDVREDndaWY 83
Cdd:COG0812 1 EPLAPHTTFRIGGPADLLVEPASEEELAALLRAAREAGLPVLVLGGGSNLLVRDDgFDGLVIRLgRLKGIEVDDG---VL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 84 LHVSSGENWHDLVQYTLQAGICGLENLALIPGLAGSAPIQNIGAYGVELKDVCEYVDLLDfSTGAIDRIPAAECGFGYRE 163
Cdd:COG0812 78 VTAGAGENWHDLVRFALEAGLSGLEFLAGIPGTVGGAPVMNAGAYGGEIKDVLESVEVLD-RTGEVRTLSAEECGFGYRD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 164 SIFKHRfqtGHVIVGLGLRLNKQwqpklSYGDLAkldpatvtplQVFESVCAMRRSKlpDPRETGNAGSFFKNPlvnaek 243
Cdd:COG0812 157 SIFKRE---RYIILSVTFRLKKG-----DPAEIA----------AVMDAVLAIRRSK--QPLELPSAGSFFKNP------ 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 244 aaeliakyPGMPhypqqdgqvklaAGWLIDQCELKGYRIGGAAVHRQQALVLVNIDNAHSQDVVALARHVRKTVADKFGV 323
Cdd:COG0812 211 --------PGDS------------AGWLIEQAGLKGYRIGGAQVSEKHANFLVNRGGATAADVLALIEEVQARVKEKFGV 270
|
....*....
gi 727166623 324 WLEPEVRFI 332
Cdd:COG0812 271 ELEPEVRII 279
|
|
| murB |
TIGR00179 |
UDP-N-acetylenolpyruvoylglucosamine reductase; This model describes MurB, ... |
8-333 |
1.57e-118 |
|
UDP-N-acetylenolpyruvoylglucosamine reductase; This model describes MurB, UDP-N-acetylenolpyruvoylglucosamine reductase, which is also called UDP-N-acetylmuramate dehydrogenase. It is part of the pathway for the biosynthesis of the UDP-N-acetylmuramoyl-pentapeptide that is a precursor of bacterial peptidoglycan. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 272945 [Multi-domain] Cd Length: 284 Bit Score: 343.67 E-value: 1.57e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 8 LKNHNTFALPVNAAHLIMADRIELMLKVWQQTRKRQEPLLILGEGSNVLFLEDFSGTVMVNQLKGIDVREDnDAWYLHVS 87
Cdd:TIGR00179 1 LAEFTTYKIGGNARHIVCPESIEQLVNVLDNAKEEDQPLLILGEGSNLLILDDGRGGVIINLGKGIDIEDD-EGEYVHVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 88 SGENWHDLVQYTLQAGICGLENLALIPGLAGSAPIQNIGAYGVELKDVCEYVDLLdFSTGAIDRIPAAECGFGYRESIFK 167
Cdd:TIGR00179 80 GGENWHKLVKYALKNGLSGLEFLAGIPGTVGGAVIMNAGAYGVEISEVLVYATIL-LATGKTEWLTNEQLGFGYRTSIFQ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 168 HRFqtghvivgLGLRLNKQWQPKLSYGDlaKLDPATVTPLQVFESVCAMRRSKLPDPretgNAGSFFKNPLvnaekaael 247
Cdd:TIGR00179 159 HKY--------VGLVLKAEFQLTLGFGT--RLDPETITAQQVFNKVCRMRTSHYPDP----NAGSFFKNPS--------- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 248 iakypgmPHYpqqdgqvklaAGWLIDQCELKGYRIGGAAVHRQQALVLVNIDNAHSQDVVALARHVRKTVADKFGVWLEP 327
Cdd:TIGR00179 216 -------PNH----------AGRLIEECGLKGYQIGGAAVSKQHANFLVNIDNAKSEDVLDLIEHVKAEVGEKYGILLEP 278
|
....*.
gi 727166623 328 EVRFIG 333
Cdd:TIGR00179 279 EVKIIG 284
|
|
| murB |
PRK13903 |
UDP-N-acetylmuramate dehydrogenase; |
3-335 |
2.11e-82 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 237552 [Multi-domain] Cd Length: 363 Bit Score: 254.50 E-value: 2.11e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 3 TESASLKNHNTFALPVNAAHLIMADRIELMLKVWQQTRKRQEPLLILGEGSNVLFLED-FSGTVMVNQLKGIDVREDNDA 81
Cdd:PRK13903 16 AEDVPLAPLTTLRVGGPARRLVTCTSTEELVAAVRELDAAGEPLLVLGGGSNLVIADDgFDGTVVRVATRGVTVDCGGGL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 82 wyLHVSSGENWHDLVQYTLQAGICGLENLALIPGLAGSAPIQNIGAYGVELKDVCEYVDLLDFSTGAIDRIPAAECGFGY 161
Cdd:PRK13903 96 --VRAEAGAVWDDVVARTVEAGLGGLECLSGIPGSAGATPVQNVGAYGQEVSDTITRVRLLDRRTGEVRWVPAADLGFGY 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 162 RESIFKHRFQtgHVI--VGLGLRLNKQWQPkLSYGDLAK---LDPATVTPL-QVFESVCAMRRSK---L-PDPRETGNAG 231
Cdd:PRK13903 174 RTSVLKHSDR--AVVleVEFQLDPSGLSAP-LRYGELARalgVEPGERVPPaAVREAVLALRAGKgmvLdPADHDTWSAG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 232 SFFKNPLVNAEKAAELIAK-----YPGMPHYPQQDGQVKLAAGWLIDQCEL-KGYRIGG--AAVHRQQALVLVNIDNAHS 303
Cdd:PRK13903 251 SFFTNPVVSPAVAERLAARvaerlGDPVPRYPAGDGGVKLSAAWLIERAGFgKGYPGGGapARLSTKHTLALTNRGGATT 330
|
330 340 350
....*....|....*....|....*....|..
gi 727166623 304 QDVVALARHVRKTVADKFGVWLEPEVRFIGAT 335
Cdd:PRK13903 331 ADLVALAREVRDGVRDAFGVTLVPEPVLVGCS 362
|
|
| murB |
PRK13905 |
UDP-N-acetylmuramate dehydrogenase; |
3-333 |
6.96e-53 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 237553 [Multi-domain] Cd Length: 298 Bit Score: 176.07 E-value: 6.96e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 3 TESASLKNHNTF---------ALPVNAAHLImadrielmlKVWQQTRKRQEPLLILGEGSNVLFLED-FSGTV--MVNQL 70
Cdd:PRK13905 14 LENEPLARYTSFrvggpadylVEPADIEDLQ---------EFLKLLKENNIPVTVLGNGSNLLVRDGgIRGVVirLGKGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 71 KGIDVREDNdawyLHVSSGENWHDLVQYTLQAGICGLENLALIPGLAGSAPIQNIGAYGVELKDVCEYVDLLDFStGAID 150
Cdd:PRK13905 85 NEIEVEGNR----ITAGAGAPLIKLARFAAEAGLSGLEFAAGIPGTVGGAVFMNAGAYGGETADVLESVEVLDRD-GEIK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 151 RIPAAECGFGYRESIFKhrfQTGHVIVGLGLRLNKqwqpklsyGDLAKLdpatvtpLQVFESVCAMRRSKLP--DPretg 228
Cdd:PRK13905 160 TLSNEELGFGYRHSALQ---EEGLIVLSATFQLEP--------GDKEEI-------KARMDELLARREATQPleYP---- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 229 NAGSFFKNPLvnaekaaeliakypgmPHYpqqdgqvklaAGWLIDQCELKGYRIGGAAVHRQQALVLVNIDNAHSQDVVA 308
Cdd:PRK13905 218 SAGSVFKNPP----------------GHF----------AGKLIEEAGLKGYRIGGAQVSEKHANFIINTGGATAADIED 271
|
330 340
....*....|....*....|....*
gi 727166623 309 LARHVRKTVADKFGVWLEPEVRFIG 333
Cdd:PRK13905 272 LIEHVQKTVKEKFGVELEWEVRIIG 296
|
|
| MurB_C |
pfam02873 |
UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Members of this family are ... |
209-332 |
3.92e-46 |
|
UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Members of this family are UDP-N-acetylenolpyruvoylglucosamine reductase enzymes EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan.
Pssm-ID: 460730 [Multi-domain] Cd Length: 99 Bit Score: 152.12 E-value: 3.92e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 209 VFESVCAMRRSKL-PDPRETGNAGSFFKNPlvnaekaaeliakypgmphypqqdgqVKLAAGWLIDQCELKGYRIGGAAV 287
Cdd:pfam02873 1 IRAAMLELRRRRLaKQPLDPPSAGSFFKNP--------------------------VGHSAGWLIEQAGLKGYRIGGAQV 54
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 727166623 288 HRQQALVLVNIDNAHSQDVVALARHVRKTVADKFGVWLEPEVRFI 332
Cdd:pfam02873 55 SEKHANFLVNTGGATAADVLALIEEVRERVKEKFGVELEPEVRII 99
|
|
| PRK14649 |
PRK14649 |
UDP-N-acetylmuramate dehydrogenase; |
40-333 |
5.91e-31 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 173112 [Multi-domain] Cd Length: 295 Bit Score: 118.79 E-value: 5.91e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 40 RKRQEPLLILGEGSNVLFL-EDFSGTVMVNQLKGIDVREDNDAWYLHVSSGENWHDLVQYTLQAGICGLENLALIPGLAG 118
Cdd:PRK14649 41 EQRQLPLFWLGGGSNLLVRdEGFDGLVARYRGQRWELHEHGDTAEVWVEAGAPMAGTARRLAAQGWAGLEWAEGLPGTIG 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 119 SAPIQNIGAYGVELKDVCEYVDLLdFSTGAIDRIPAAECGFGYRESIFKHRFQTGhvivglglrlnKQWQPKLSYGDLAK 198
Cdd:PRK14649 121 GAIYGNAGCYGGDTATVLIRAWLL-LNGSECVEWSVHDFAYGYRTSVLKQLRADG-----------ITWRPPLVLAARFR 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 199 L---DPATVTplQVFESVCAMRRSKLPdprETGNAGSFFKNPlvnaekaaeliakyPGMphypqqdgqvklAAGWLIDQC 275
Cdd:PRK14649 189 LhrdDPTALA--ARMEAIAAERKQKTP---AGSSCGSVFKNP--------------PGD------------SAGRLIEAA 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 727166623 276 ELKGYRIGGAAVHRQQALVLVNIDNAHSQDVVALARHVRKTVADKFGVWLEPEVRFIG 333
Cdd:PRK14649 238 GLKGTRIGDAEIATRHANYIINLGGARAADILRLIDLARTRVLAQFGIELELEVRIIG 295
|
|
| PRK14653 |
PRK14653 |
UDP-N-acetylmuramate dehydrogenase; |
8-329 |
1.18e-28 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 237778 [Multi-domain] Cd Length: 297 Bit Score: 112.62 E-value: 1.18e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 8 LKNHNTFALPVNAAHLIMADRIELMLKVWQQTRKRQEpLLILGEGSNVLFLEDFSGTVMV--NQLKGIDVREDNdawyLH 85
Cdd:PRK14653 22 MKCHVSFKIGGPVPLFAIPNSTNGFIETINLLKEGIE-VKILGNGTNVLPKDEPMDFVVVstERLDDIFVDNDK----II 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 86 VSSGENWHDLVQYTLQAGICGLENLALIPGLAGSAPIQNIGAYGVELKDVCEYVDLLDfsTGAIDRIPAAECGFGYRESI 165
Cdd:PRK14653 97 CESGLSLKKLCLVAAKNGLSGFENAYGIPGSVGGAVYMNAGAYGWETAENIVEVVAYD--GKKIIRLGKNEIKFSYRNSI 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 166 FKHrfQTGHVIVGLGLRLNKQwQPKLSYGDLAKLdpatvtplqvfesvcaMRRSKLPDPRETGNAGSFFKNplvnaekaa 245
Cdd:PRK14653 175 FKE--EKDLIILRVTFKLKKG-NKNEIYNLMLET----------------MKKRVEKQPLEFPSAGSVFKR--------- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 246 eliakypgmphyPQQDGQVklaaGWLIDQCELKGYRIGGAAVHRQQALVLVNIDNAHSQDVVALARHVRKTVADKFGVWL 325
Cdd:PRK14653 227 ------------PRKDFYV----GSAIEKLGLKGFSIGGAQISEKHAGFIINYNNAKAEDVLKLIEYVKDKIYENYNVEL 290
|
....
gi 727166623 326 EPEV 329
Cdd:PRK14653 291 ETEI 294
|
|
| murB |
PRK13906 |
UDP-N-acetylmuramate dehydrogenase; |
19-333 |
1.23e-24 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 184386 [Multi-domain] Cd Length: 307 Bit Score: 101.82 E-value: 1.23e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 19 NAAHLIMADRIELMLKVWQQTRKRQEPLLILGEGSNVLFLED-FSGTVM-VNQLKGIDVREDNdawyLHVSSGENWHDLV 96
Cdd:PRK13906 36 NADFYITPTKNEEVQAVVKYAYQNEIPVTYLGNGSNIIIREGgIRGIVIsLLSLDHIEVSDDA----IIAGSGAAIIDVS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 97 QYTLQAGICGLENLALIPGLAGSAPIQNIGAYGVELKDVCEYVDLLDfSTGAIDRIPAAECGFGYRESIFkhrfQTGHVI 176
Cdd:PRK13906 112 RVARDYALTGLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDYALCVN-EQGSLIKLTTKELELDYRNSII----QKEHLV 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 177 VglglrLNKQWqpklsygdlaKLDPATVTPLQ-VFESVCAMRRSKlpDPRETGNAGSFFKNPlvnaekaaeliakyPGmp 255
Cdd:PRK13906 187 V-----LEAAF----------TLAPGKMTEIQaKMDDLTERRESK--QPLEYPSCGSVFQRP--------------PG-- 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727166623 256 HYpqqdgqvklaAGWLIDQCELKGYRIGGAAVHRQQALVLVNIDNAHSQDVVALARHVRKTVADKFGVWLEPEVRFIG 333
Cdd:PRK13906 234 HF----------AGKLIQDSNLQGHRIGGVEVSTKHAGFMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRIIG 301
|
|
| PRK12436 |
PRK12436 |
UDP-N-acetylmuramate dehydrogenase; |
8-333 |
2.20e-23 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 171497 [Multi-domain] Cd Length: 305 Bit Score: 98.16 E-value: 2.20e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 8 LKNHNTFALPVNAAHLIMADRIELMLKVWQQTRKRQEPLLILGEGSNVLFLED-FSG-TVMVNQLKGIDVREDNdawyLH 85
Cdd:PRK12436 25 LKNHTHIKVGGKADVFVAPTNYDEIQEVIKYANKYNIPVTFLGNGSNVIIKDGgIRGiTVSLIHITGVTVTGTT----IV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 86 VSSGENWHDLVQYTLQAGICGLENLALIPGLAGSAPIQNIGAYGVELKDVCEYVDLLDfSTGAIDRIPAAECGFGYRESI 165
Cdd:PRK12436 101 AQCGAAIIDVSRIALDHNLTGLEFACGIPGSVGGALYMNAGAYGGEISFVLTEAVVMT-GDGELRTLTKEAFEFGYRKSV 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 166 FKHRFqtgHVIVGLGLRLNKQWQPKLSygdlAKLDPATVTplqvfesvcamRRSKlpDPRETGNAGSFFKNPLVNaekaa 245
Cdd:PRK12436 180 FANNH---YIILEARFELEEGVYEEIK----AKMDDLTFK-----------RESK--QPLEYPSCGSVFKRPPNN----- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 246 eliakypgmphypqqdgqvklAAGWLIDQCELKGYRIGGAAVHRQQALVLVNIDNAHSQDVVALARHVRKTVADKFGVWL 325
Cdd:PRK12436 235 ---------------------FAGKLIQESGLQGKRIGGVEVSLKHAGFMVNVDNGTAQDYIDLIHFVQKTVEEKFGVKL 293
|
....*...
gi 727166623 326 EPEVRFIG 333
Cdd:PRK12436 294 EREVRIIG 301
|
|
| PRK14652 |
PRK14652 |
UDP-N-acetylmuramate dehydrogenase; |
40-333 |
2.27e-21 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 237777 [Multi-domain] Cd Length: 302 Bit Score: 92.63 E-value: 2.27e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 40 RKRQEPLLILGEGSNVLfLEDFSGTVMVNQLKGIDVREDNDAWYLHVSSGENWHDLVQYTLQAGICGLENLALIPGLAGS 119
Cdd:PRK14652 56 RELGVPLSILGGGANTL-VADAGVRGVVLRLPQDFPGESTDGGRLVLGAGAPISRLPARAHAHGLVGMEFLAGIPGTLGG 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 120 APIQNIGAYGVELKDVCEYVDLLdfSTGAIDRIPAAECGFGYRESifkhRFQTGHVIVGLGLRLNKqwqpklsyGDLAkl 199
Cdd:PRK14652 135 AVAMNAGTKLGEMKDVVTAVELA--TADGAGFVPAAALGYAYRTC----RLPPGAVITRVEVRLRP--------GDVA-- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 200 dpatvtplqvfESVCAMR----RSKLPDPRETGNAGSFFKNPlvnaekaaeliakyPGMphypqqdgqvklAAGWLIDQC 275
Cdd:PRK14652 199 -----------ASEALMRadreRRRRTQPLDRPTFGSTFTNP--------------PGD------------YAGRLVEAV 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 727166623 276 ELKGYRIGGAAVHRQQALVLVNIDNAHSQDVVALARHVRKTVADKFGVWLEPEVRFIG 333
Cdd:PRK14652 242 GLKGHRVGGAIWSPVHANFVTNLGGATARDVLALVRLARARVKERFGIALETEVRLLG 299
|
|
| PRK14651 |
PRK14651 |
UDP-N-acetylmuramate dehydrogenase; |
43-328 |
2.73e-20 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 237776 [Multi-domain] Cd Length: 273 Bit Score: 89.11 E-value: 2.73e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 43 QEPLLILGEGSNvLFLEDFSGTVMVNQLKGIDVREDNDAWylhVSSGENWHDLVQYTLQAGICGLENLALIPGLAGSAPI 122
Cdd:PRK14651 37 EAPYRVLGGGSN-LLVSDAGVPERVIRLGGEFAEWDLDGW---VGGGVPLPGLVRRAARLGLSGLEGLVGIPAQVGGAVK 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 123 QNIGAYGVELKDVCEYVDLldFSTGAIDRIPAAECGFGYRESifkhRFQTGHVIVGLGLRLNKQwqpklsygdlakldpa 202
Cdd:PRK14651 113 MNAGTRFGEMADALHTVEI--VHDGGFHQYSPDELGFGYRHS----GLPPGHVVTRVRLKLRPS---------------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 203 tvTPLQVFESVCAMRRSKLPDPRETgNAGSFFKNPlvnaekaaeliakyPGMphypqqdgqvklAAGWLIDQCELKGYRI 282
Cdd:PRK14651 171 --TPEAVLAKMALVDAARKGQPKKK-SAGCAFKNP--------------PGD------------SAGRLIDEAGLKGTRV 221
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 727166623 283 GGAAVHRQQALVLVNIDNAHSQDVVALARHVRKTVadkfGVWLEPE 328
Cdd:PRK14651 222 GDAMISPEHGNFIVNLGGATAADVHALLRRVRARV----GLPLELE 263
|
|
| FAD_binding_4 |
pfam01565 |
FAD binding domain; This family consists of various enzymes that use FAD as a co-factor, most ... |
14-143 |
1.88e-17 |
|
FAD binding domain; This family consists of various enzymes that use FAD as a co-factor, most of the enzymes are similar to oxygen oxidoreductase. One of the enzymes Vanillyl-alcohol oxidase (VAO) has a solved structure, the alignment includes the FAD binding site, called the PP-loop, between residues 99-110. The FAD molecule is covalently bound in the known structure, however the residue that links to the FAD is not in the alignment. VAO catalyzes the oxidation of a wide variety of substrates, ranging form aromatic amines to 4-alkylphenols. Other members of this family include D-lactate dehydrogenase, this enzyme catalyzes the conversion of D-lactate to pyruvate using FAD as a co-factor; mitomycin radical oxidase, this enzyme oxidizes the reduced form of mitomycins and is involved in mitomycin resistance. This family includes MurB an UDP-N-acetylenolpyruvoylglucosamine reductase enzyme EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan.
Pssm-ID: 426326 [Multi-domain] Cd Length: 139 Bit Score: 77.63 E-value: 1.88e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 14 FALPVNAAHLImadrielmlKVWQQTRKRQEPLLILGEGSNVLFLEDFSGTVMVN--QLKGIdVREDNDAWYLHVSSGEN 91
Cdd:pfam01565 4 VVLPESEEEVA---------AIVRLANENGLPVLPRGGGSSLLGGAVQTGGIVLDlsRLNGI-LEIDPEDGTATVEAGVT 73
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 727166623 92 WHDLVQYTLQAGIC-GLENLALIPGLAGSAPIQNIGAYGVEL----KDVCEYVDLLD 143
Cdd:pfam01565 74 LGDLVRALAAKGLLlGLDPGSGIPGTVGGAIATNAGGYGSEKygltRDNVLGLEVVL 130
|
|
| murB |
PRK13904 |
UDP-N-acetylmuramate dehydrogenase; |
75-329 |
1.45e-16 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 184384 [Multi-domain] Cd Length: 257 Bit Score: 78.04 E-value: 1.45e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 75 VREDNDawYLHVSSGENWHDLVQYTLQAGICGLENLALIPGLAGSAPIQNIGAYGVELKDVCEYVDLLDfstgaiDRIPA 154
Cdd:PRK13904 62 IKIDGE--CLEIGGATKSGKIFNYAKKNNLGGFEFLGKLPGTLGGLVKMNAGLKEYEISNNLESICTNG------GWIEK 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 155 AECGFGYRES-----IFKHRFqtghvivglglrlnkqwqpKLSYGDLAKLDpatvtplqvfESVCAMRRS--KLPdpret 227
Cdd:PRK13904 134 EDIGFGYRSSgingvILEARF-------------------KKTHGFDEELL----------EAFKSMRKNqpKGP----- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 228 gNAGSFFKNPlvnaekaaeliakyPGmpHYpqqdgqvklaAGWLIDQCELKGYRIGGAAVHRQQALVLVNIDNAHSQDVV 307
Cdd:PRK13904 180 -SFGSCFKNP--------------KG--DY----------AGRLIEAVGLKGYCKGGAGFSEEHANFLVNLGGATFEDAL 232
|
250 260
....*....|....*....|..
gi 727166623 308 ALARHVRKTVADKFGVWLEPEV 329
Cdd:PRK13904 233 DLIELAKKRVLEEFGINLEEEV 254
|
|
| PRK14650 |
PRK14650 |
UDP-N-acetylmuramate dehydrogenase; |
4-333 |
2.07e-13 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 173113 [Multi-domain] Cd Length: 302 Bit Score: 69.87 E-value: 2.07e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 4 ESASLKNHNTFALPVNAAHLIMADRIELMLKVWQQTRKRQEPLLILGEGSNVLFLE----DFSgTVMVNQLKGIDVREDN 79
Cdd:PRK14650 17 QTKNLANYTTYKIGGISKLFLTPKTIKDAEHIFKAAIEEKIKIFILGGGSNILINDeeeiDFP-IIYTGHLNKIEIHDNQ 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 80 dawyLHVSSGENWHDLVQYTLQAGICGLENLALIPGLAGSAPIQNIGAYGVELKDVCEYVDLLDFSTGAIDRIPAAEcGF 159
Cdd:PRK14650 96 ----IVAECGTNFEDLCKFALQNELSGLEFIYGLPGTLGGAIWMNARCFGNEISEILDKITFIDEKGKTICKKFKKE-EF 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 160 GYRESIFKHRfqtGHVIVGLGLRLNKQ----WQPKLSYGDLAKLDPATVtplqVFESvcamrrsklpdpretgnAGSFFK 235
Cdd:PRK14650 171 KYKISPFQNK---NTFILKATLNLKKGnkkhIEEIMKQNKQIRINKGHY----LFPS-----------------SGSTFK 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 236 NplvnaEKAaeliakypgmphYPQQDGQVklaagwlIDQCELKGYRIGGAAVHRQQALVLVNIDNAHSQDVVALARHVRK 315
Cdd:PRK14650 227 N-----NKA------------FLKPTGQI-------IEECKLKGLSIGGATVSHYHGNFIININNATSKDIKTLIEKVKT 282
|
330
....*....|....*...
gi 727166623 316 TVADKFGVWLEPEVRFIG 333
Cdd:PRK14650 283 EVQIKTGFLLEEEVLYIG 300
|
|
| PRK14648 |
PRK14648 |
UDP-N-acetylmuramate dehydrogenase; |
37-335 |
5.19e-09 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 173111 [Multi-domain] Cd Length: 354 Bit Score: 57.04 E-value: 5.19e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 37 QQTRKRQEPLLILGEGSNVLFLEDFSGTVMVN--QLKGIDVREDNDAWYL-HVSSGENWHDLVQYTLQAGICGLENLALI 113
Cdd:PRK14648 47 EEAQRARIPLSLIGGGSNVLIADEGVPGLMLSlrRFRSLHTQTQRDGSVLvHAGAGLPVAALLAFCAHHALRGLETFAGL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 114 PGLAGSAPIQNIGAYGVELKDV--------------------------------CEYVDLLDFSTGAIDRIPAAECGFGY 161
Cdd:PRK14648 127 PGSVGGAAYMNARCYGRAIADCfhsartlvlhpvrsrakelpevrknaqdkrgeCLGLDGGPFTCSSFQTVFARAGDWGY 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 162 RESifkhRFQTGHvivglGLRLNKQWQPKLSYgdLAKLDPAtvTPLQVFESVcamrRSKLPDPRETG-----NAGSFFKN 236
Cdd:PRK14648 207 KRS----PFQSPH-----GVELHAGRRLILSL--CVRLTPG--NPAQIRKHM----QEKIADRISKGqfrfpSAGSAFKN 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166623 237 PlvnaekaaeliakypgmPHYPQqdgqvklAAGWLIDQCELKGYRIGGAAVHRQQALVLVNIDNAHSQDVVALARHVRKT 316
Cdd:PRK14648 270 N-----------------PAFGK-------PSGILIEEAGLRGTSCGAAQVAPWHGNLIINTGNATAHQVRTLLRVVRQR 325
|
330
....*....|....*....
gi 727166623 317 VADKFGVWLEPEVRFIGAT 335
Cdd:PRK14648 326 VFETHGVWLEREIIFSGES 344
|
|
| |
