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Conserved domains on  [gi|727169815|ref|WP_033638048|]
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MULTISPECIES: manganese-binding transcriptional regulator MntR [Serratia]

Protein Classification

manganese-binding transcriptional regulator MntR( domain architecture ID 11485168)

manganese-binding transcriptional regulator MntR, in the presence of manganese, represses the expression of mntH and mntS, and up-regulates the expression of mntP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11050 PRK11050
manganese-binding transcriptional regulator MntR;
15-155 5.68e-73

manganese-binding transcriptional regulator MntR;


:

Pssm-ID: 182927 [Multi-domain]  Cd Length: 152  Bit Score: 215.65  E-value: 5.68e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727169815  15 TDMPDEAEHALRFSRAREAQSNALIEDYVELIADLLQSTREARTTDIARRFGVSHPTAIKNIARLKSAGLVESRPYRGVF 94
Cdd:PRK11050  11 TQLVDVEEHVEGFRQVREAHRRELIEDYVELIADLIAEVGEARQVDIAARLGVSQPTVAKMLKRLARDGLVEMRPYRGVF 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727169815  95 LTEEGELLAQKVRRRHRIVVDLLMCVGVPSETAELDSEGIEHHISDETLAVFEHYLQKHAK 155
Cdd:PRK11050  91 LTPEGEKLAQESRERHQIVENFLLALGVSPETARRDAEGIEHHVSEETLAAFRRFLQRHGA 151
 
Name Accession Description Interval E-value
PRK11050 PRK11050
manganese-binding transcriptional regulator MntR;
15-155 5.68e-73

manganese-binding transcriptional regulator MntR;


Pssm-ID: 182927 [Multi-domain]  Cd Length: 152  Bit Score: 215.65  E-value: 5.68e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727169815  15 TDMPDEAEHALRFSRAREAQSNALIEDYVELIADLLQSTREARTTDIARRFGVSHPTAIKNIARLKSAGLVESRPYRGVF 94
Cdd:PRK11050  11 TQLVDVEEHVEGFRQVREAHRRELIEDYVELIADLIAEVGEARQVDIAARLGVSQPTVAKMLKRLARDGLVEMRPYRGVF 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727169815  95 LTEEGELLAQKVRRRHRIVVDLLMCVGVPSETAELDSEGIEHHISDETLAVFEHYLQKHAK 155
Cdd:PRK11050  91 LTPEGEKLAQESRERHQIVENFLLALGVSPETARRDAEGIEHHVSEETLAAFRRFLQRHGA 151
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
39-152 1.33e-39

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 130.32  E-value: 1.33e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727169815  39 IEDYVELIADLLQSTREARTTDIARRFGVSHPTAIKNIARLKSAGLVESRPYRGVFLTEEGELLAQKVRRRHRIVVDLLM 118
Cdd:COG1321    8 EEDYLKAIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITLTEEGRELALRIVRRHRLLERFLV 87

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 727169815 119 CV-GVPSETAELDSEGIEHHISDETLAVFEHYLQK 152
Cdd:COG1321   88 EVlGVDWDEAHEEAERLEHVLSDETIERLDAFLGF 122
HTH_DTXR smart00529
Helix-turn-helix diphteria tox regulatory element; iron dependent repressor
 58-151 4.68e-24

Helix-turn-helix diphteria tox regulatory element; iron dependent repressor


Pssm-ID: 197774 [Multi-domain]  Cd Length: 95  Bit Score: 89.58  E-value: 4.68e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727169815    58 TTDIARRFGVSHPTAIKNIARLKSAGLVESRPYRGVFLTEEGELLAQKVRRRHRIVVDLLMCV-GVPSETAELDSEGIEH 136
Cdd:smart00529   1 TSEIAERLNVSPPTVTEMLKKLEKMGLVEYEPYRGITLTEKGRRLARRLLRKHRLLERFLVDVlGVDEEEVHEEAERLEH 80

                           90
                   ....*....|....*
gi 727169815   137 HISDETLAVFEHYLQ 151
Cdd:smart00529  81 VLSDELEDRLDRFLG 95
Fe_dep_repress pfam01325
Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria ...
 39-93 1.46e-10

Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria toxin repressor. DNA binding is through a helix-turn-helix motif.


Pssm-ID: 396062 [Multi-domain]  Cd Length: 57  Bit Score: 53.53  E-value: 1.46e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 727169815   39 IEDYVELIADLLQSTREARTTDIARRFGVSHPTAIKNIARLKSAGLVESRPYRGV 93
Cdd:pfam01325   3 TEDYLETIYTLSEEKGVVKTKDLAERLNVSPSTVSEMLKKLEKMGYVDYEPYKGL 57
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 48-96 7.10e-05

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 38.97  E-value: 7.10e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 727169815  48 DLLQSTREarttdIARRFGVSHPTAIKNIARLKSAGLVESRPYRGVFLT 96
Cdd:cd07377   23 DRLPSERE-----LAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 46-92 2.45e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 36.56  E-value: 2.45e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 727169815   46 IADLLQSTREARTTDIARRFGVSHPTAIKNIARLKSAGLVESRPYRG 92
Cdd:TIGR01884 148 ILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVEQKGRKG 194
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 46-88 6.24e-03

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 33.97  E-value: 6.24e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 727169815  46 IADLLqSTREARTTDIARRFGVSHPTAIKNIARLKSAGLVESR 88
Cdd:NF033788  16 ILELL-AEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSR 57
 
Name Accession Description Interval E-value
PRK11050 PRK11050
manganese-binding transcriptional regulator MntR;
15-155 5.68e-73

manganese-binding transcriptional regulator MntR;


Pssm-ID: 182927 [Multi-domain]  Cd Length: 152  Bit Score: 215.65  E-value: 5.68e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727169815  15 TDMPDEAEHALRFSRAREAQSNALIEDYVELIADLLQSTREARTTDIARRFGVSHPTAIKNIARLKSAGLVESRPYRGVF 94
Cdd:PRK11050  11 TQLVDVEEHVEGFRQVREAHRRELIEDYVELIADLIAEVGEARQVDIAARLGVSQPTVAKMLKRLARDGLVEMRPYRGVF 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727169815  95 LTEEGELLAQKVRRRHRIVVDLLMCVGVPSETAELDSEGIEHHISDETLAVFEHYLQKHAK 155
Cdd:PRK11050  91 LTPEGEKLAQESRERHQIVENFLLALGVSPETARRDAEGIEHHVSEETLAAFRRFLQRHGA 151
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
39-152 1.33e-39

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 130.32  E-value: 1.33e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727169815  39 IEDYVELIADLLQSTREARTTDIARRFGVSHPTAIKNIARLKSAGLVESRPYRGVFLTEEGELLAQKVRRRHRIVVDLLM 118
Cdd:COG1321    8 EEDYLKAIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITLTEEGRELALRIVRRHRLLERFLV 87

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 727169815 119 CV-GVPSETAELDSEGIEHHISDETLAVFEHYLQK 152
Cdd:COG1321   88 EVlGVDWDEAHEEAERLEHVLSDETIERLDAFLGF 122
HTH_DTXR smart00529
Helix-turn-helix diphteria tox regulatory element; iron dependent repressor
 58-151 4.68e-24

Helix-turn-helix diphteria tox regulatory element; iron dependent repressor


Pssm-ID: 197774 [Multi-domain]  Cd Length: 95  Bit Score: 89.58  E-value: 4.68e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727169815    58 TTDIARRFGVSHPTAIKNIARLKSAGLVESRPYRGVFLTEEGELLAQKVRRRHRIVVDLLMCV-GVPSETAELDSEGIEH 136
Cdd:smart00529   1 TSEIAERLNVSPPTVTEMLKKLEKMGLVEYEPYRGITLTEKGRRLARRLLRKHRLLERFLVDVlGVDEEEVHEEAERLEH 80

                           90
                   ....*....|....*
gi 727169815   137 HISDETLAVFEHYLQ 151
Cdd:smart00529  81 VLSDELEDRLDRFLG 95
PRK03902 PRK03902
transcriptional regulator MntR;
40-143 2.77e-18

transcriptional regulator MntR;


Pssm-ID: 179669 [Multi-domain]  Cd Length: 142  Bit Score: 75.80  E-value: 2.77e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727169815  40 EDYVELIADLLQSTREARTTDIARRFGVsHPTAI-KNIARLKSAGLVESRPYRGVFLTEEGELLAQKVRRRHRIVVDLLM 118
Cdd:PRK03902   7 EDYIEQIYLLIEEKGYARVSDIAEALSV-HPSSVtKMVQKLDKDEYLIYEKYRGLVLTPKGKKIGKRLVYRHELLEQFLR 85

                         90       100
                 ....*....|....*....|....*
gi 727169815 119 CVGVPSETAELDSEGIEHHISDETL 143
Cdd:PRK03902  86 IIGVDESKIYNDVEGIEHHLSWNAI 110
Fe_dep_repress pfam01325
Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria ...
 39-93 1.46e-10

Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria toxin repressor. DNA binding is through a helix-turn-helix motif.


Pssm-ID: 396062 [Multi-domain]  Cd Length: 57  Bit Score: 53.53  E-value: 1.46e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 727169815   39 IEDYVELIADLLQSTREARTTDIARRFGVSHPTAIKNIARLKSAGLVESRPYRGV 93
Cdd:pfam01325   3 TEDYLETIYTLSEEKGVVKTKDLAERLNVSPSTVSEMLKKLEKMGYVDYEPYKGL 57
Fe_dep_repr_C pfam02742
Iron dependent repressor, metal binding and dimerization domain; This family includes the ...
 96-143 4.53e-10

Iron dependent repressor, metal binding and dimerization domain; This family includes the Diphtheria toxin repressor. It acts as an iron-binding repressor of diphtheria toxin gene expression and may serve as a global regulator of gene expression. DTXR comprises an N-terminal DNA-binding domain, an interface domain (which contains two metal-binding sites) and a third, very flexible C-terminal domain. The second domain is responsible for dimerization and metal binding. Binding of DTXR to Tox operator requires a divalent metal ion such as cobalt, ferric, manganese and nickel whereas zinc shows weak activation. This domain can also bind Cd(II), Ca(II) and Cu(II) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426954  Cd Length: 69  Bit Score: 52.47  E-value: 4.53e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 727169815   96 TEEGELLAQKVRRRHRIVVDLL-MCVGVPSETAELDSEGIEHHISDETL 143
Cdd:pfam02742   1 TEKGRKIALRVVRRHRLLERFLvDVLGVDWDEVHEEAERLEHALSDELI 49
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
59-119 3.50e-05

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 40.66  E-value: 3.50e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 727169815    59 TDIARRFGVSHPTAIKNIARLKSAGLVESRPYRG------VFLTEEGELLAQKVRRRHRIVVDLLMC 119
Cdd:smart00347  28 SELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEdrrsvlVSLTEEGRELIEQLLEARSETLAELLA 94
COG3432 COG3432
Predicted transcriptional regulator [Transcription];
43-113 5.17e-05

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442658 [Multi-domain]  Cd Length: 83  Bit Score: 39.47  E-value: 5.17e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727169815  43 VELIADLLQSTRE--ARTTDIARRFGVSHPTAIKNIARLKSAGLVESRPYRG---VFLTEEGELLAQKVRRRHRIV 113
Cdd:COG3432    7 LEIIADILEALKNegAKKTRIMYKANLSYDRLKKYLDLLEEKGLIEKEDDGGrriYRITEKGREFLEKYEEIKELL 82
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 48-96 7.10e-05

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 38.97  E-value: 7.10e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 727169815  48 DLLQSTREarttdIARRFGVSHPTAIKNIARLKSAGLVESRPYRGVFLT 96
Cdd:cd07377   23 DRLPSERE-----LAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
49-152 2.63e-04

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 38.80  E-value: 2.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727169815  49 LLQSTREARTTDIARRFGVSHPTAIKNIARLKSAGLVESRP------YRGVFLTEEGELLAQKVRRRHRIVVDLLMcvgv 122
Cdd:COG1846   46 ALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPdpedrrAVLVRLTEKGRALLEEARPALEALLAELL---- 121

                         90       100       110
                 ....*....|....*....|....*....|
gi 727169815 123 psetaeldsegieHHISDETLAVFEHYLQK 152
Cdd:COG1846  122 -------------AGLSEEELEALLRLLRR 138
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 54-103 3.42e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 37.28  E-value: 3.42e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 727169815  54 REARTTDIARRFGVSHPTAIKNIARLKSAGLVESR---PYRGVFLTEEGELLA 103
Cdd:cd00090   19 GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRregRRVYYSLTDAERLLA 71
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
46-89 5.08e-04

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 37.18  E-value: 5.08e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 727169815  46 IADLLqSTREARTTDIARRFGVSHPTAIKNIARLKSAGLVESRP 89
Cdd:COG0640   25 ILRLL-AEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRR 67
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
48-94 9.42e-04

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 35.63  E-value: 9.42e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 727169815    48 DLLQSTREarttdIARRFGVSHPTAIKNIARLKSAGLVESRPYRGVF 94
Cdd:smart00345  18 DKLPSERE-----LAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTF 59
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
 44-92 1.38e-03

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 35.10  E-value: 1.38e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 727169815   44 ELIADLLQSTREART-TDIARRFGVSHPTAIKNIARLKSAGL-VESRPYRG 92
Cdd:pfam08279   1 LQILQLLLEARGPISgQELAEKLGVSRRTIRRDIKILEELGVpIEAEPGRG 51
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 60-94 2.29e-03

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 34.90  E-value: 2.29e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 727169815   60 DIARRFGVSHPTAIKNIARLKSAGLVESRPYRGVF 94
Cdd:pfam00392  29 ELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTF 63
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 46-92 2.45e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 36.56  E-value: 2.45e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 727169815   46 IADLLQSTREARTTDIARRFGVSHPTAIKNIARLKSAGLVESRPYRG 92
Cdd:TIGR01884 148 ILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVEQKGRKG 194
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
54-88 2.65e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 34.49  E-value: 2.65e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 727169815    54 REARTTDIARRFGVSHPTAIKNIARLKSAGLVESR 88
Cdd:smart00418   9 GELCVCELAEILGLSQSTVSHHLKKLREAGLVESR 43
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
52-132 2.72e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 35.78  E-value: 2.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727169815  52 STREARTTDIARRFGVSHPTAIKNIARLKSAGLVESRPYRGvfltEEGellaqKVRRRHRIVVDLLMCVGVPSETAELDS 131
Cdd:COG1777   27 SEEPAYVSELARELGVSRQAVYKHLRKLEEAGLVESYREGR----EDG-----RARKYYRLSAFRLEVTLTPDLFARLAR 97


                 .
gi 727169815 132 E 132
Cdd:COG1777   98 E 98
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 44-86 2.93e-03

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 36.65  E-value: 2.93e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 727169815  44 ELIADLLQSTREARTTDIARRFGVSHPTAIKNIARLKSAGLVE 86
Cdd:COG1349    8 QKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLR 50
COG3177 COG3177
Fic family protein [Transcription];
19-88 3.13e-03

Fic family protein [Transcription];


Pssm-ID: 442410 [Multi-domain]  Cd Length: 316  Bit Score: 36.59  E-value: 3.13e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727169815  19 DEAEHALRFSRAREAQSNALIEDYVELIADLLQSTREARTTDIARRFGVSHPTAIKNIARLKSAGLVESR 88
Cdd:COG3177  239 EAAEEALALLERLLELARGRLNERQRKLLELLFENPVLTASELAELLGVSRRTARRDLKDLVELGILEKV 308
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 59-89 3.53e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 34.10  E-value: 3.53e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 727169815   59 TDIARRFGVSHPTAIKNIARLKSAGLVESRP 89
Cdd:pfam12802  23 AELARRLGISKQTVSRLVKRLEAKGLVEREP 53
Rrf2 pfam02082
Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur ...
 49-93 3.55e-03

Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur clusters enabling iron dependent DNA transcription regulation. The iron binding is mediated by three conserved cysteine residues. Members of this family can also bind O-acetyl-L-serine, [Fe-S] and nitric oxide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 396591 [Multi-domain]  Cd Length: 131  Bit Score: 35.61  E-value: 3.55e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 727169815   49 LLQSTREARTTDIARRFGVSHPTAIKNIARLKSAGLVESRpyRGV 93
Cdd:pfam02082  17 LHPGGEPVTSEEIAERQNISPVYLEKILAKLRKAGLVESV--RGA 59
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
54-113 4.40e-03

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 36.03  E-value: 4.40e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727169815  54 REARTTDIARRFGVSHPTAIKNIARLKSAGLVESrpYRGVF-LTEEGELLAQKVRRRHRIV 113
Cdd:COG4742   28 GPKTRSELAESLDVSRSTILRQLKELEERGLIER--DDGEYeLTTLGRLVVEEMEPLLDTL 86
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 46-88 6.24e-03

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 33.97  E-value: 6.24e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 727169815  46 IADLLqSTREARTTDIARRFGVSHPTAIKNIARLKSAGLVESR 88
Cdd:NF033788  16 ILELL-AEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSR 57
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
52-93 7.91e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 34.17  E-value: 7.91e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 727169815  52 STREARTTDIARRFGVSHPTAIKNIARLKSAGLVESRPYRGV 93
Cdd:COG4189   29 AEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEYKPGK 70
CasRa_I-A cd09655
CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly ...
 46-92 9.53e-03

CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Predicted transcriptional regulator of CRISPR/Cas system


Pssm-ID: 187786 [Multi-domain]  Cd Length: 198  Bit Score: 35.05  E-value: 9.53e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 727169815  46 IADLLQSTREARTTDIARRFGVSHPTAIKNIARLKSAGLVESRPYRG 92
Cdd:cd09655  144 ILEVLKAKGEKSVKNIAKKLGKSLSTISRHLRELEKKGLVEQKGTKG 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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