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Conserved domains on  [gi|727178650|ref|WP_033642028|]
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MULTISPECIES: GNAT family N-acetyltransferase [Serratia]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10006981)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
9-153 1.19e-18

Predicted N-acetyltransferase YhbS [General function prediction only];


:

Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 76.66  E-value: 1.19e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727178650   9 SDCPQFADVCAAwAFGQwgsqrggslERTQLRFAQCSRPGDDHLTLMMIDGDRPVGMASLWPSDDHqRQDLTPWLAGVFV 88
Cdd:COG3153    7 EDAEAIAALLRA-AFGP---------GREAELVDRLREDPAAGLSLVAEDDGEIVGHVALSPVDID-GEGPALLLGPLAV 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 727178650  89 HPDHRRKGIARRLEMAIVEAARQRHHSVLHLITD-KSEALYAGWGWQPLERRR-QHDEEVVVMEKKL 153
Cdd:COG3153   76 DPEYRGQGIGRALMRAALEAARERGARAVVLLGDpSLLPFYERFGFRPAGELGlTLGPDEVFLAKEL 142
 
Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
9-153 1.19e-18

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 76.66  E-value: 1.19e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727178650   9 SDCPQFADVCAAwAFGQwgsqrggslERTQLRFAQCSRPGDDHLTLMMIDGDRPVGMASLWPSDDHqRQDLTPWLAGVFV 88
Cdd:COG3153    7 EDAEAIAALLRA-AFGP---------GREAELVDRLREDPAAGLSLVAEDDGEIVGHVALSPVDID-GEGPALLLGPLAV 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 727178650  89 HPDHRRKGIARRLEMAIVEAARQRHHSVLHLITD-KSEALYAGWGWQPLERRR-QHDEEVVVMEKKL 153
Cdd:COG3153   76 DPEYRGQGIGRALMRAALEAARERGARAVVLLGDpSLLPFYERFGFRPAGELGlTLGPDEVFLAKEL 142
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 49-129 7.41e-12

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 58.68  E-value: 7.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727178650   49 DDHLTLMMIDGDRPVGMASLWPSDDHQRqdlTPWLAGVFVHPDHRRKGIARRLEMAIVEAARQRHHSVLHLITDK----S 124
Cdd:pfam00583  31 ASEGFFVAEEDGELVGFASLSIIDDEPP---VGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAAdnlaA 107


                  ....*
gi 727178650  125 EALYA 129
Cdd:pfam00583 108 IALYE 112
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 58-119 1.15e-11

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 56.52  E-value: 1.15e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727178650  58 DGDRPVGMASLWPSDDHQRqdlTPWLAGVFVHPDHRRKGIARRLEMAIVEAARQRHHSVLHL 119
Cdd:cd04301    6 DDGEIVGFASLSPDGSGGD---TAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRL 64
mycothiol_MshD TIGR03448
mycothiol synthase; Members of this family are MshD, the acetyltransferase that catalyzes the ...
 45-108 7.47e-05

mycothiol synthase; Members of this family are MshD, the acetyltransferase that catalyzes the final step of mycothiol biosynthesis in various members of the Actinomyctes, Mycothiol replaces glutathione in these species. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]


Pssm-ID: 132489 [Multi-domain]  Cd Length: 292  Bit Score: 41.23  E-value: 7.47e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727178650   45 SRPGDDHLT-LMMIDGDRPVGMASLWPSDDHQrqdltPWLAGVFVHPDHRRKGIARRLEMAIVEA 108
Cdd:TIGR03448  39 REPGAGHTRhLVAVDSDPIVGYANLVPARGTD-----PAMAELVVHPAHRRRGIGRALIRALLAK 98
PRK01346 PRK01346
enhanced intracellular survival protein Eis;
1-101 1.08e-04

enhanced intracellular survival protein Eis;


Pssm-ID: 234945 [Multi-domain]  Cd Length: 411  Bit Score: 41.07  E-value: 1.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727178650   1 MTQRIIPLSDCPQFADVCAAwAFGQWGSqrggslERTQLRFAQCSRPGDdhlTLMMIDGDRPVGMASLWPSD---DHQRQ 77
Cdd:PRK01346   7 ITIRTATEEDWPAWFRAAAT-GFGDSPS------DEELEAWRALVEPDR---TLGAFDGDEVVGTAGAFDLRltvPGGAV 76

                         90       100
                 ....*....|....*....|....
gi 727178650  78 DLTPWLAGVFVHPDHRRKGIARRL 101
Cdd:PRK01346  77 LPAAGVTAVTVAPTHRRRGLLTAL 100
 
Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
9-153 1.19e-18

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 76.66  E-value: 1.19e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727178650   9 SDCPQFADVCAAwAFGQwgsqrggslERTQLRFAQCSRPGDDHLTLMMIDGDRPVGMASLWPSDDHqRQDLTPWLAGVFV 88
Cdd:COG3153    7 EDAEAIAALLRA-AFGP---------GREAELVDRLREDPAAGLSLVAEDDGEIVGHVALSPVDID-GEGPALLLGPLAV 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 727178650  89 HPDHRRKGIARRLEMAIVEAARQRHHSVLHLITD-KSEALYAGWGWQPLERRR-QHDEEVVVMEKKL 153
Cdd:COG3153   76 DPEYRGQGIGRALMRAALEAARERGARAVVLLGDpSLLPFYERFGFRPAGELGlTLGPDEVFLAKEL 142
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 58-153 7.15e-14

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 64.24  E-value: 7.15e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727178650  58 DGDRPVGMASLwpsddHQRQDLTPWLAGVFVHPDHRRKGIARRLEMAIVEAARQRHHSVLHLIT-DKSEALYAGWGWQPL 136
Cdd:COG1246   35 EDGEIVGCAAL-----HPLDEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTtSAAIHFYEKLGFEEI 109

                         90       100
                 ....*....|....*....|..
gi 727178650 137 ER-----RRQHDEEVVVMEKKL 153
Cdd:COG1246  110 DKedlpyAKVWQRDSVVMEKDL 131
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 64-153 2.02e-13

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 61.98  E-value: 2.02e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727178650  64 GMASLWPSDDHQRQdltpWLAGVFVHPDHRRKGIARRLEMAIVEAARQRHHSVLHLITDKS----EALYAGWGWQPLERR 139
Cdd:COG0456    1 GFALLGLVDGGDEA----EIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDneaaIALYEKLGFEEVGER 76

                         90
                 ....*....|....*
gi 727178650 140 RQH-DEEVVVMEKKL 153
Cdd:COG0456   77 PNYyGDDALVMEKEL 91
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
33-153 1.01e-12

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 61.93  E-value: 1.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727178650  33 SLERTQLRFAQCSRPGddHLTLMMIDGDRPVGMASLWPSDDHQRQDLTPWLAgVFVHPDHRRKGIARRLeM-AIVEAARQ 111
Cdd:COG1247   36 SEEEREAWFAAILAPG--RPVLVAEEDGEVVGFASLGPFRPRPAYRGTAEES-IYVDPDARGRGIGRAL-LeALIERARA 111

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 727178650 112 RHHSVLHLITDK----SEALYAGWGWQPLERRRQHDE------EVVVMEKKL 153
Cdd:COG1247  112 RGYRRLVAVVLAdneaSIALYEKLGFEEVGTLPEVGFkfgrwlDLVLMQKRL 163
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
61-135 1.42e-12

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 59.54  E-value: 1.42e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 727178650  61 RPVGMASLWPSDDHqrqdlTPWLAGVFVHPDHRRKGIARRLEMAIVEAARQRHHSVLHLITDK----SEALYAGWGWQP 135
Cdd:COG3393    1 ELVAMAGVRAESPG-----VAEISGVYTHPEYRGRGLASALVAALAREALARGARTPFLYVDAdnpaARRLYERLGFRP 74
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 49-129 7.41e-12

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 58.68  E-value: 7.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727178650   49 DDHLTLMMIDGDRPVGMASLWPSDDHQRqdlTPWLAGVFVHPDHRRKGIARRLEMAIVEAARQRHHSVLHLITDK----S 124
Cdd:pfam00583  31 ASEGFFVAEEDGELVGFASLSIIDDEPP---VGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAAdnlaA 107


                  ....*
gi 727178650  125 EALYA 129
Cdd:pfam00583 108 IALYE 112
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 58-119 1.15e-11

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 56.52  E-value: 1.15e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727178650  58 DGDRPVGMASLWPSDDHQRqdlTPWLAGVFVHPDHRRKGIARRLEMAIVEAARQRHHSVLHL 119
Cdd:cd04301    6 DDGEIVGFASLSPDGSGGD---TAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRL 64
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 49-135 1.34e-10

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 54.38  E-value: 1.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727178650   49 DDHLTLMMIDGDRPVGMASLWPSDDHQrqdlTPWLAGVFVHPDHRRKGIARRLEMAIVEAARQRHHSVLHLITDKSEA-L 127
Cdd:pfam13508   1 PGGRFFVAEDDGKIVGFAALLPLDDEG----ALAELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTNRAAaF 76


                  ....*...
gi 727178650  128 YAGWGWQP 135
Cdd:pfam13508  77 YEKLGFEE 84
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 58-153 3.17e-09

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 51.89  E-value: 3.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727178650   58 DGDRPVGMASLwpsDDHQRqdltpwLAGVFVHPDHRRKGIARRLeMAIVEAARQRHHSVLHLIT----DKSEALYAGWGW 133
Cdd:pfam13673  38 EGGQIVGVIAL---RDRGH------ISLLFVDPDYQGQGIGKAL-LEAVEDYAEKDGIKLSELTvnasPYAVPFYEKLGF 107

                          90       100
                  ....*....|....*....|.
gi 727178650  134 QPLERRRQHDE-EVVVMEKKL 153
Cdd:pfam13673 108 RATGPEQEFNGiRFVPMEKEL 128
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 58-153 1.60e-08

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 50.05  E-value: 1.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727178650  58 DGDRPVGMASLWPSDDHqrqdlTPWLAGVFVHPDHRRKGIARRLEMAIVEAARQRHHSVLHLIT----DKSEALYAGWGW 133
Cdd:COG0454   41 DKGEPIGFAGLRRLDDK-----VLELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALELDTldgnPAAIRFYERLGF 115

                         90       100
                 ....*....|....*....|
gi 727178650 134 QPLERRRqhDEEVVVMEKKL 153
Cdd:COG0454  116 KEIERYV--AYVGGEFEKEL 133
Eis COG4552
Predicted acetyltransferase [General function prediction only];
1-133 4.65e-07

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 443616 [Multi-domain]  Cd Length: 393  Bit Score: 47.97  E-value: 4.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727178650   1 MTQRIIPLSDCPQFADVcAAWAFGQwgsqrGGSLERTQlRFAQCSRPGDdhlTLMMIDGDRPVGMASLWPSDDHQRQDLT 80
Cdd:COG4552    1 MEIRPLTEDDLDAFARL-LAYAFGP-----EPDDEELE-AYRPLLEPGR---VLGVFDDGELVGTLALYPFTLNVGGARV 70

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 727178650  81 P--WLAGVFVHPDHRRKGIARRLEMAIVEAARQRHH--SVLHLItdkSEALYAGWGW 133
Cdd:COG4552   71 PmaGITGVAVAPEHRRRGVARALLREALAELRERGQplSALYPF---EPGFYRRFGY 124
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
49-153 3.80e-06

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 43.63  E-value: 3.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727178650  49 DDHLTLMMIDGDRPVGMASLWPSDDHqrqdlTPWLAGVFVHPDHRRKGIARRLEMAIVEAARQRHHSVLHLITDKS-EAL 127
Cdd:COG2153   32 EDARHLLAYDDGELVATARLLPPGDG-----EAKIGRVAVLPEYRGQGLGRALMEAAIEEARERGARRIVLSAQAHaVGF 106

                         90       100       110
                 ....*....|....*....|....*....|.
gi 727178650 128 YAGWGWQP-----LERRRQHdeevVVMEKKL 153
Cdd:COG2153  107 YEKLGFVPvgeefLEAGIPH----IDMRKPL 133
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 1-112 7.17e-06

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 43.45  E-value: 7.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727178650   1 MTQRII--PL--SDCPQFADVCAAWAFGQWGSQRGGSLERTQLRFAQCSRPGDDHLTLMMI----DGDRPVGMASLWPSD 72
Cdd:COG1670    4 ETERLRlrPLrpEDAEALAELLNDPEVARYLPGPPYSLEEARAWLERLLADWADGGALPFAiedkEDGELIGVVGLYDID 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 727178650  73 DHQRqdlTPWLaGVFVHPDHRRKGIARRLEMAIVEAARQR 112
Cdd:COG1670   84 RANR---SAEI-GYWLAPAYWGKGYATEALRALLDYAFEE 119
Acetyltransf_9 pfam13527
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 58-133 6.06e-05

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 404421 [Multi-domain]  Cd Length: 124  Bit Score: 40.25  E-value: 6.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727178650   58 DGDRPVGMASLWPSD--DHQRQDLTPWLAGVFVHPDHRRKGIARRLEMAIVEAARQRHH--SVLHLItdkSEALYAGWGW 133
Cdd:pfam13527  46 DDGELVSTLALYPFElnVPGKTLPAAGITGVATYPEYRGRGVMSRLLRRSLEEMRERGVplSFLYPS---SYPIYRRFGY 122
mycothiol_MshD TIGR03448
mycothiol synthase; Members of this family are MshD, the acetyltransferase that catalyzes the ...
 45-108 7.47e-05

mycothiol synthase; Members of this family are MshD, the acetyltransferase that catalyzes the final step of mycothiol biosynthesis in various members of the Actinomyctes, Mycothiol replaces glutathione in these species. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]


Pssm-ID: 132489 [Multi-domain]  Cd Length: 292  Bit Score: 41.23  E-value: 7.47e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727178650   45 SRPGDDHLT-LMMIDGDRPVGMASLWPSDDHQrqdltPWLAGVFVHPDHRRKGIARRLEMAIVEA 108
Cdd:TIGR03448  39 REPGAGHTRhLVAVDSDPIVGYANLVPARGTD-----PAMAELVVHPAHRRRGIGRALIRALLAK 98
Acetyltransf_13 pfam13880
ESCO1/2 acetyl-transferase;
86-125 9.06e-05

ESCO1/2 acetyl-transferase;


Pssm-ID: 464015  Cd Length: 69  Bit Score: 38.62  E-value: 9.06e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 727178650   86 VFVHPDHRRKGIARRLemaiVEAArqRHHSVLHLITDKSE 125
Cdd:pfam13880  10 IWVSPSHRRKGIATRL----LDAA--RSNFIYGYILEKDE 43
PRK01346 PRK01346
enhanced intracellular survival protein Eis;
1-101 1.08e-04

enhanced intracellular survival protein Eis;


Pssm-ID: 234945 [Multi-domain]  Cd Length: 411  Bit Score: 41.07  E-value: 1.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727178650   1 MTQRIIPLSDCPQFADVCAAwAFGQWGSqrggslERTQLRFAQCSRPGDdhlTLMMIDGDRPVGMASLWPSD---DHQRQ 77
Cdd:PRK01346   7 ITIRTATEEDWPAWFRAAAT-GFGDSPS------DEELEAWRALVEPDR---TLGAFDGDEVVGTAGAFDLRltvPGGAV 76

                         90       100
                 ....*....|....*....|....
gi 727178650  78 DLTPWLAGVFVHPDHRRKGIARRL 101
Cdd:PRK01346  77 LPAAGVTAVTVAPTHRRRGLLTAL 100
COG3981 COG3981
Predicted acetyltransferase [General function prediction only];
54-117 1.11e-03

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 443180  Cd Length: 170  Bit Score: 37.20  E-value: 1.11e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727178650  54 LMMIDGDRPVGMASLwpsddhqRQDLTPWLA------GVFVHPDHRRKGIARR-LEMAIVEAARQRHHSVL 117
Cdd:COG3981   66 WLVDEDGRIVGAINL-------RHELNEFLLrvgghiGYGVRPSERGKGYATEmLRLALEEARELGLDRVL 129
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
 83-140 1.20e-03

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 36.15  E-value: 1.20e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727178650   83 LAGVFVHPDHRRKGIARRLEMAIVEAARQRHHSVLHLI---TDKSEALYAGWGWQPLERRR 140
Cdd:pfam08445  24 LGALQTLPEHRRRGLGSRLVAALARGIAERGITPFAVVvagNTPSRRLYEKLGFRKIDETY 84
PTZ00330 PTZ00330
acetyltransferase; Provisional
 86-143 2.07e-03

acetyltransferase; Provisional


Pssm-ID: 140351 [Multi-domain]  Cd Length: 147  Bit Score: 36.36  E-value: 2.07e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 727178650  86 VFVHPDHRRKGIARRLEMAIVEAARQRH-HSVLHLITDKSEALYAGWGWQPLERRRQHD 143
Cdd:PTZ00330  88 VVVDPSYRGQGLGRALISDLCEIARSSGcYKVILDCTEDMVAFYKKLGFRACERQMRLD 146
PRK03624 PRK03624
putative acetyltransferase; Provisional
 48-153 2.49e-03

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 36.06  E-value: 2.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727178650  48 GDDHLTLMMIDGDRPVG--MASLwpsDDHQrqdltPWLAGVFVHPDHRRKGIARRLeMAIVEAA-RQRHHSVLHLI---- 120
Cdd:PRK03624  42 HDPSLFLVAEVGGEVVGtvMGGY---DGHR-----GWAYYLAVHPDFRGRGIGRAL-VARLEKKlIARGCPKINLQvred 112

                         90       100       110
                 ....*....|....*....|....*....|...
gi 727178650 121 TDKSEALYAGWGWQplerrrqhDEEVVVMEKKL 153
Cdd:PRK03624 113 NDAVLGFYEALGYE--------EQDRISLGKRL 137
Acetyltransf_CG pfam14542
GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both ...
 87-117 6.57e-03

GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.


Pssm-ID: 434030 [Multi-domain]  Cd Length: 79  Bit Score: 33.65  E-value: 6.57e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 727178650   87 FVHPDHRRKGIARRLEMAIVEAARQRHHSVL 117
Cdd:pfam14542  30 EVPPALRGQGIASKLVKAALDDAREEGLKIV 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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