NCBI Conserved Domain Search

Conserved domains on [gi|727180512|ref|WP_033642984|]

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MULTISPECIES: osmoprotectant ABC transporter ATP-binding protein OsmV [Serratia]

Protein Classification

ABC transporter ATP-binding protein( domain architecture ID 11438324)

ABC transporter ATP-binding protein/permease contains the ATPase catalytic subunit and permease component of an ATP transporter complex responsible for coupling the energy of ATP hydrolysis to the import of one or more from a variety of substrates

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

OpuBA

COG1125

ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and ...

1-311

0e+00

ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism];

Pssm-ID: 440742 [Multi-domain] Cd Length: 306 Bit Score: 548.92 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqKNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRR 80
Cdd:COG1125    1 MIEFENVTKRY--PDGTV--AVDDLSLTIPAGEFTVLVGPSGCGKTTTLRMINRLIEPTSGRILIDGEDIRDLDPVELRR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKRFLHRYPKEMSGGQQQRIGVIRALAADPP 160
Cdd:COG1125   77 RIGYVIQQIGLFPHMTVAENIATVPRLLGWDKERIRARVDELLELVGLDPEEYRDRYPHELSGGQQQRVGVARALAADPP 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 161 VLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEFVASF 240
Cdd:COG1125  157 ILLMDEPFGALDPITREQLQDELLRLQRELGKTIVFVTHDIDEALKLGDRIAVMREGRIVQYDTPEEILANPANDFVADF 236

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727180512 241 VGQDRTLKRLLLVQAGDVAgQQETVTVRRETPLVEAFGLMDDIDARSVTVVDADGKPLGYVKRREARGAPG 311
Cdd:COG1125  237 VGADRGLRRLSLLRVEDLM-LPEPPTVSPDASLREALSLMLERGVDWLLVVDEDGRPLGWLTLEDLLRALA 306

CBS_pair_ABC_OpuCA_assoc

cd04582

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found associated with ...

258-368

3.38e-61

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found associated with the ABC transporter OpuCA; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment but the function of the CBS domains in OpuCA remains unknown. In the related ABC transporter, OpuA, the tandem CBS domains have been shown to function as sensors for ionic strength, whereby they control the transport activity through an electronic switching mechanism. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. They are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).

Pssm-ID: 341359 [Multi-domain] Cd Length: 111 Bit Score: 192.22 E-value: 3.38e-61

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 258 VAGQQETVTVRRETPLVEAFGLMDDIDARSVTVVDADGKPLGYVKRREARGAPGVCADSLHRFRVTARAEENLRVVLSKL 337
Cdd:cd04582    1 EDAATPTPTVRPSTPLSDALGIMDDADSRYLVVVDADGRPLGYVTRRDARGASGTCGDFAHPFKATVPVDENLRVVLSRM 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 727180512 338 YEHNTSWMPIVDEDGRYSGEISQDYIADYLS 368
Cdd:cd04582   81 YEHNTSWLPVVDEDGRYAGEVTQDSIADYLS 111

Name

Accession

Description

Interval

E-value

OpuBA

COG1125

ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and ...

1-311

0e+00

ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism];

Pssm-ID: 440742 [Multi-domain] Cd Length: 306 Bit Score: 548.92 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqKNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRR 80
Cdd:COG1125    1 MIEFENVTKRY--PDGTV--AVDDLSLTIPAGEFTVLVGPSGCGKTTTLRMINRLIEPTSGRILIDGEDIRDLDPVELRR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKRFLHRYPKEMSGGQQQRIGVIRALAADPP 160
Cdd:COG1125   77 RIGYVIQQIGLFPHMTVAENIATVPRLLGWDKERIRARVDELLELVGLDPEEYRDRYPHELSGGQQQRVGVARALAADPP 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 161 VLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEFVASF 240
Cdd:COG1125  157 ILLMDEPFGALDPITREQLQDELLRLQRELGKTIVFVTHDIDEALKLGDRIAVMREGRIVQYDTPEEILANPANDFVADF 236

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727180512 241 VGQDRTLKRLLLVQAGDVAgQQETVTVRRETPLVEAFGLMDDIDARSVTVVDADGKPLGYVKRREARGAPG 311
Cdd:COG1125  237 VGADRGLRRLSLLRVEDLM-LPEPPTVSPDASLREALSLMLERGVDWLLVVDEDGRPLGWLTLEDLLRALA 306

ABC_OpuCA_Osmoprotection

cd03295

ATP-binding cassette domain of the osmoprotectant transporter; OpuCA is a the ATP binding ...

2-247

1.49e-143

ATP-binding cassette domain of the osmoprotectant transporter; OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition, to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213262 [Multi-domain] Cd Length: 242 Bit Score: 407.07 E-value: 1.49e-143

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFmqKNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRK 81
Cdd:cd03295    1 IEFENVTKRY--GGGKK--AVNNLNLEIAKGEFLVLIGPSGSGKTTTMKMINRLIEPTSGEIFIDGEDIREQDPVELRRK 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKRFLHRYPKEMSGGQQQRIGVIRALAADPPV 161
Cdd:cd03295   77 IGYVIQQIGLFPHMTVEENIALVPKLLKWPKEKIRERADELLALVGLDPAEFADRYPHELSGGQQQRVGVARALAADPPL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 162 LLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEFVASFV 241
Cdd:cd03295  157 LLMDEPFGALDPITRDQLQEEFKRLQQELGKTIVFVTHDIDEAFRLADRIAIMKNGEIVQVGTPDEILRSPANDFVAEFV 236


                 ....*.
gi 727180512 242 GQDRTL 247
Cdd:cd03295  237 GADRLL 242

proV

TIGR01186

glycine betaine/L-proline transport ATP binding subunit; This model describes the glycine ...

21-371

1.44e-108

glycine betaine/L-proline transport ATP binding subunit; This model describes the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. Functionally, this transport system is involved in osmoregulation. Under conditions of stress, the organism recruits these transport system to accumulate glycine betaine and other solutes which offer osmo-protection. It has been demonstrated that glycine betaine uptake is accompanied by symport with sodium ions. The locus has been named variously as proU or opuA. A gene library from L.lactis functionally complements an E.coli proU mutant. The comlementing locus is similar to a opuA locus in B.sutlis. This clarifies the differences in nomenclature. [Transport and binding proteins, Amino acids, peptides and amines]

Pssm-ID: 130254 [Multi-domain] Cd Length: 363 Bit Score: 322.57 E-value: 1.44e-108

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   21 AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSL----RRKIGYVIQQIGLFPNMT 96
Cdd:TIGR01186   8 GVNDADLAIAKGEIFVIMGLSGSGKSTTVRMLNRLIEPTAGQIFIDGENIMKQSPVELrevrRKKIGMVFQQFALFPHMT 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   97 IEENITVVPRMLGWDKKRCHARAEELMSMVALDpkRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINR 176
Cdd:TIGR01186  88 ILQNTSLGPELLGWPEQERKEKALELLKLVGLE--EYEHRYPDELSGGMQQRVGLARALAAEPDILLMDEAFSALDPLIR 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  177 ETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEFVASFVGQDRTLKRLllvQAG 256
Cdd:TIGR01186 166 DSMQDELKKLQATLQKTIVFITHDLDEAIRIGDRIVIMKAGEIVQVGTPDEILRNPANEYVEEFIGKVDLSQVF---DAE 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  257 DVAGQQET--VTVRRETPLVEAFGLMDDIDARSVTVVDADGKPLGYVK---RREARGAPGVCADSLHRFRVTARAEENLR 331
Cdd:TIGR01186 243 RIAQRMNTgpITKTADKGPRSALQLMRDERVDSLYVVDRQNKLVGVVDvesIKQARKKAQGLQDVLIDDIYTVDAGTLLR 322

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 727180512  332 VVLSKLYEHNTSwMPIVDEDGRYSGEISQDYIADYLSSGR 371
Cdd:TIGR01186 323 ETVRKVLKAGIK-VPVVDEDQRLVGIVTRGSLVDALYDSR 361

potA

PRK09452

spermidine/putrescine ABC transporter ATP-binding protein PotA;

2-243

8.26e-64

spermidine/putrescine ABC transporter ATP-binding protein PotA;

Pssm-ID: 236523 [Multi-domain] Cd Length: 375 Bit Score: 208.26 E-value: 8.26e-64

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFmqkNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDtvSLRRK 81
Cdd:PRK09452  15 VELRGISKSF---DGKE--VISNLDLTINNGEFLTLLGPSGCGKTTVLRLIAGFETPDSGRIMLDGQDITHVP--AENRH 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDpkRFLHRYPKEMSGGQQQRIGVIRALAADPPV 161
Cdd:PRK09452  88 VNTVFQSYALFPHMTVFENVAFGLRMQKTPAAEITPRVMEALRMVQLE--EFAQRKPHQLSGGQQQRVAIARAVVNKPKV 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 162 LLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEFVASFV 241
Cdd:PRK09452 166 LLLDESLSALDYKLRKQMQNELKALQRKLGITFVFVTHDQEEALTMSDRIVVMRDGRIEQDGTPREIYEEPKNLFVARFI 245


                 ..
gi 727180512 242 GQ 243
Cdd:PRK09452 246 GE 247

CBS_pair_ABC_OpuCA_assoc

cd04582

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found associated with ...

258-368

3.38e-61

Pssm-ID: 341359 [Multi-domain] Cd Length: 111 Bit Score: 192.22 E-value: 3.38e-61

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 258 VAGQQETVTVRRETPLVEAFGLMDDIDARSVTVVDADGKPLGYVKRREARGAPGVCADSLHRFRVTARAEENLRVVLSKL 337
Cdd:cd04582    1 EDAATPTPTVRPSTPLSDALGIMDDADSRYLVVVDADGRPLGYVTRRDARGASGTCGDFAHPFKATVPVDENLRVVLSRM 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 727180512 338 YEHNTSWMPIVDEDGRYSGEISQDYIADYLS 368
Cdd:cd04582   81 YEHNTSWLPVVDEDGRYAGEVTQDSIADYLS 111

ABC_tran

pfam00005

ABC transporter; ABC transporters for a large family of proteins responsible for translocation ...

22-168

3.12e-52

ABC transporter; ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains.

Pssm-ID: 394964 [Multi-domain] Cd Length: 150 Bit Score: 170.52 E-value: 3.12e-52

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   22 VDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRKIGYVIQQIGLFPNMTIEENI 101
Cdd:pfam00005   1 LKNVSLTLNPGEILALVGPNGAGKSTLLKLIAGLLSPTEGTILLDGQDLTDDERKSLRKEIGYVFQDPQLFPRLTVRENL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 727180512  102 TVVPRMLGWDKKRCHARAEELMSMVAL--DPKRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPF 168
Cdd:pfam00005  81 RLGLLLKGLSKREKDARAEEALEKLGLgdLADRPVGERPGTLSGGQRQRVAIARALLTKPKLLLLDEPT 149

ABC_ATP_DarD

NF038007

darobactin export ABC transporter ATP-binding protein;

1-219

1.39e-35

darobactin export ABC transporter ATP-binding protein;

Pssm-ID: 411600 [Multi-domain] Cd Length: 218 Bit Score: 129.45 E-value: 1.39e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQKNgTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSAL---DTVS 77
Cdd:NF038007   1 MLNMQNAEKCYITKT-IKTKVLNHLNFSVEKGDFVSIMGPSGSGKSTLLNIIGMFDSLDSGSLTLAGKEVTNLsysQKII 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  78 LRRK-IGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIGVIRALA 156
Cdd:NF038007  80 LRRElIGYIFQSFNLIPHLSIFDNVALPLKYRGVAKKERIERVNQVLNLFGIDNRR--NHKPMQLSGGQQQRVAIARAMV 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 157 ADPPVLLMDEPFGAVDPIN-RETIQnefldmqrQLKK------TVMLVSHDiDEALKLGDRIAVFRQGKI 219
Cdd:NF038007 158 SNPALLLADEPTGNLDSKNaRAVLQ--------QLKYinqkgtTIIMVTHS-DEASTYGNRIINMKDGKL 218

AztA

NF040873

zinc ABC transporter ATP-binding protein AztA;

21-205

1.53e-25

zinc ABC transporter ATP-binding protein AztA;

Pssm-ID: 468810 [Multi-domain] Cd Length: 191 Bit Score: 101.93 E-value: 1.53e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  21 AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTIlingedtsaldTVSLRRKIGYVIQQIGL---FPnMTI 97
Cdd:NF040873   7 VLHGVDLTIPAGSLTAVVGPNGSGKSTLLKVLAGVLRPTSGTV-----------RRAGGARVAYVPQRSEVpdsLP-LTV 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  98 EENITV--VPRMLGWDKKRCHARAEELMSMVALDPKRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPIN 175
Cdd:NF040873  75 RDLVAMgrWARRGLWRRLTRDDRAAVDDALERVGLADLAGRQLGELSGGQRQRALLAQGLAQEADLLLLDEPTTGLDAES 154

                        170       180       190
                 ....*....|....*....|....*....|
gi 727180512 176 RETIqNEFLDMQRQLKKTVMLVSHDIDEAL 205
Cdd:NF040873 155 RERI-IALLAEEHARGATVVVVTHDLELVR 183

ABC2_perm_RbbA

NF033858

ribosome-associated ATPase/putative transporter RbbA;

2-231

1.53e-22

ribosome-associated ATPase/putative transporter RbbA;

Pssm-ID: 468210 [Multi-domain] Cd Length: 907 Bit Score: 99.43 E-value: 1.53e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFmqknGTpFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDtVSLRRK 81
Cdd:NF033858 267 IEARGLTMRF----GD-FTAVDHVSFRIRRGEIFGFLGSNGCGKSTTMKMLTGLLPASEGEAWLFGQPVDAGD-IATRRR 340

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPkrFLHRYPKEMSGGQQQRIgvirALAA---- 157
Cdd:NF033858 341 VGYMSQAFSLYGELTVRQNLELHARLFHLPAAEIAARVAEMLERFDLAD--VADALPDSLPLGIRQRL----SLAVavih 414

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 727180512 158 DPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLgDRIAVFRQGKIVQNASADELLAR 231
Cdd:NF033858 415 KPELLILDEPTSGVDPVARDMFWRLLIELSREDGVTIFISTHFMNEAERC-DRISLMHAGRVLASDTPAALVAA 487

ABC2_perm_RbbA

NF033858

ribosome-associated ATPase/putative transporter RbbA;

21-231

2.17e-18

ribosome-associated ATPase/putative transporter RbbA;

Pssm-ID: 468210 [Multi-domain] Cd Length: 907 Bit Score: 87.10 E-value: 2.17e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  21 AVDNINLDVPEGEICVLLGPSGCGKTTTLKMIN--RLIEptGGTILINGED-TSALDTVSLRRKIGYVIQQIG--LFPNM 95
Cdd:NF033858  16 ALDDVSLDIPAGCMVGLIGPDGVGKSSLLSLIAgaRKIQ--QGRVEVLGGDmADARHRRAVCPRIAYMPQGLGknLYPTL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  96 TIEENITVVPRMLGWDKKRCHARAEELMSMVALDPkrFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPIN 175
Cdd:NF033858  94 SVFENLDFFGRLFGQDAAERRRRIDELLRATGLAP--FADRPAGKLSGGMKQKLGLCCALIHDPDLLILDEPTTGVDPLS 171

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727180512 176 R-------ETIQNEFLDMqrqlkkTVMLVSHDIDEALKLgDRIAVFRQGKIVQNASADELLAR 231
Cdd:NF033858 172 RrqfweliDRIRAERPGM------SVLVATAYMEEAERF-DWLVAMDAGRVLATGTPAELLAR 227

40850658_otr

NF000106

oxytetracycline efflux ABC transporter Otr(C) ATP-binding subunit;

2-228

3.72e-17

oxytetracycline efflux ABC transporter Otr(C) ATP-binding subunit;

Pssm-ID: 411078 [Multi-domain] Cd Length: 351 Bit Score: 81.71 E-value: 3.72e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFMQkngtpFNAVDNINLDVPEGEICVLLGPSGCGKTTTlKMINRLIEPTGGTILINGEdTSALDTVSLRRK 81
Cdd:NF000106  14 VEVRGLVKHFGE-----VKAVDGVDLDVREGTVLGVLGP*GAA**RG-ALPAHV*GPDAGRRPWRF*-TWCANRRALRRT 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IG-YVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIGVIRALAADPP 160
Cdd:NF000106  87 IG*HRPVR*GRRESFSGRENLYMIGR*LDLSRKDARARADELLERFSLTEAA--GRAAAKYSGGMRRRLDLAASMIGRPA 164

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727180512 161 VLLMDEPFGAVDPINRETIQNEFLDMQRQlKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADEL 228
Cdd:NF000106 165 VLYLDEPTTGLDPRTRNEVWDEVRSMVRD-GATVLLTTQYMEEAEQLAHELTVIDRGRVIADGKVDEL 231

GguA

NF040905

sugar ABC transporter ATP-binding protein;

21-221

1.13e-16

sugar ABC transporter ATP-binding protein;

Pssm-ID: 468840 [Multi-domain] Cd Length: 500 Bit Score: 81.37 E-value: 1.13e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  21 AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRlIEPTG---GTILINGEdTSALDTVSLRRKIGYVI--QQIGLFPNM 95
Cdd:NF040905  16 ALDDVNLSVREGEIHALCGENGAGKSTLMKVLSG-VYPHGsyeGEILFDGE-VCRFKDIRDSEALGIVIihQELALIPYL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  96 TIEENItvvprMLG----------WDkkRCHARAEELMSMVALD--PKRFLhrypKEMSGGQQQRIGVIRALAADPPVLL 163
Cdd:NF040905  94 SIAENI-----FLGnerakrgvidWN--ETNRRARELLAKVGLDesPDTLV----TDIGVGKQQLVEIAKALSKDVKLLI 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727180512 164 MDEPFGAvdpINRETIQNeFLDMQRQLKK---TVMLVSHDIDEALKLGDRIAVFRQGKIVQ 221
Cdd:NF040905 163 LDEPTAA---LNEEDSAA-LLDLLLELKAqgiTSIIISHKLNEIRRVADSITVLRDGRTIE 219

COG3448

CBS-domain-containing membrane protein [Signal transduction mechanisms];

265-367

1.66e-10

CBS-domain-containing membrane protein [Signal transduction mechanisms];

Pssm-ID: 442671 [Multi-domain] Cd Length: 136 Bit Score: 58.34 E-value: 1.66e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 265 VTVRRETPLVEAFGLMDDIDARSVTVVDADGKPLGYV-----KRREARGAPGVCADSLHRFRV---------TARAEENL 330
Cdd:COG3448   13 VTVSPDTTLREALELMREHGIRGLPVVDEDGRLVGIVterdlLRALLPDRLDELEERLLDLPVedvmtrpvvTVTPDTPL 92

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 727180512 331 RVVLSKLYEHNTSWMPIVDEDGRYSGEISQDYIADYL 367
Cdd:COG3448   93 EEAAELMLEHGIHRLPVVDDDGRLVGIVTRTDLLRAL 129

AAA

smart00382

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...

32-216

3.18e-10

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.

Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 58.15 E-value: 3.18e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512    32 GEICVLLGPSGCGKTTTLKMINRLIEPTGGT-ILINGEDTSALDTVSLRRKIGyviqqiglfpnmtieenitvvprmlgw 110
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPGGGvIYIDGEDILEEVLDQLLLIIV--------------------------- 54

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   111 dkkrcharaeelmsmvaldpkrflHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRETIQ-----NEFLD 185
Cdd:smart00382  55 ------------------------GGKKASGSGELRLRLALALARKLKPDVLILDEITSLLDAEQEALLLlleelRLLLL 110

                          170       180       190
                   ....*....|....*....|....*....|.
gi 727180512   186 MQRQLKKTVMLVSHDIDEALKLGDRIAVFRQ 216
Cdd:smart00382 111 LKSEKNLTVILTTNDEKDLGPALLRRRFDRR 141

GguA

NF040905

sugar ABC transporter ATP-binding protein;

22-227

8.41e-06

sugar ABC transporter ATP-binding protein;

Pssm-ID: 468840 [Multi-domain] Cd Length: 500 Bit Score: 47.48 E-value: 8.41e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  22 VDNINLDVPEGEICVLLGPSGCGKTTtLKM------INRLIeptGGTILINGEDTSaLDTVS--LRRKIGYVIQ---QIG 90
Cdd:NF040905 276 VDDVSLNVRRGEIVGIAGLMGAGRTE-LAMsvfgrsYGRNI---SGTVFKDGKEVD-VSTVSdaIDAGLAYVTEdrkGYG 350

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  91 LFPNMTIEENITVvPRMLGWDKKRCHARAEELMsmVAldpkrflHRYPKEM--------------SGGQQQRIGVIRALA 156
Cdd:NF040905 351 LNLIDDIKRNITL-ANLGKVSRRGVIDENEEIK--VA-------EEYRKKMniktpsvfqkvgnlSGGNQQKVVLSKWLF 420

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727180512 157 ADPPVLLMDEP-----FGAVDPInrETIQNEFLDMqrqlKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADE 227
Cdd:NF040905 421 TDPDVLILDEPtrgidVGAKYEI--YTIINELAAE----GKGVIVISSELPELLGMCDRIYVMNEGRITGELPREE 490

CBS

pfam00571

CBS domain; CBS domains are small intracellular modules that pair together to form a stable ...

322-369

8.34e-05

CBS domain; CBS domains are small intracellular modules that pair together to form a stable globular domain. This family represents a single CBS domain. Pairs of these domains have been termed a Bateman domain. CBS domains have been shown to bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet. CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl carrying ligands. The region containing the CBS domains in Cystathionine-beta synthase is involved in regulation by S-AdoMet. CBS domain pairs from AMPK bind AMP or ATP. The CBS domains from IMPDH and the chloride channel CLC2 bind ATP.

Pssm-ID: 425756 [Multi-domain] Cd Length: 57 Bit Score: 39.89 E-value: 8.34e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 727180512  322 VTARAEENLRVVLSKLYEHNTSWMPIVDEDGRYSGEISQDYIADYLSS 369
Cdd:pfam00571  10 VTVSPDTTLEEALELMREHGISRLPVVDEDGKLVGIVTLKDLLRALLG 57

Name

Accession

Description

Interval

E-value

OpuBA

COG1125

ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and ...

1-311

0e+00

ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism];

Pssm-ID: 440742 [Multi-domain] Cd Length: 306 Bit Score: 548.92 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqKNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRR 80
Cdd:COG1125    1 MIEFENVTKRY--PDGTV--AVDDLSLTIPAGEFTVLVGPSGCGKTTTLRMINRLIEPTSGRILIDGEDIRDLDPVELRR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKRFLHRYPKEMSGGQQQRIGVIRALAADPP 160
Cdd:COG1125   77 RIGYVIQQIGLFPHMTVAENIATVPRLLGWDKERIRARVDELLELVGLDPEEYRDRYPHELSGGQQQRVGVARALAADPP 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 161 VLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEFVASF 240
Cdd:COG1125  157 ILLMDEPFGALDPITREQLQDELLRLQRELGKTIVFVTHDIDEALKLGDRIAVMREGRIVQYDTPEEILANPANDFVADF 236

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727180512 241 VGQDRTLKRLLLVQAGDVAgQQETVTVRRETPLVEAFGLMDDIDARSVTVVDADGKPLGYVKRREARGAPG 311
Cdd:COG1125  237 VGADRGLRRLSLLRVEDLM-LPEPPTVSPDASLREALSLMLERGVDWLLVVDEDGRPLGWLTLEDLLRALA 306

ABC_OpuCA_Osmoprotection

cd03295

ATP-binding cassette domain of the osmoprotectant transporter; OpuCA is a the ATP binding ...

2-247

1.49e-143

Pssm-ID: 213262 [Multi-domain] Cd Length: 242 Bit Score: 407.07 E-value: 1.49e-143

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFmqKNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRK 81
Cdd:cd03295    1 IEFENVTKRY--GGGKK--AVNNLNLEIAKGEFLVLIGPSGSGKTTTMKMINRLIEPTSGEIFIDGEDIREQDPVELRRK 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKRFLHRYPKEMSGGQQQRIGVIRALAADPPV 161
Cdd:cd03295   77 IGYVIQQIGLFPHMTVEENIALVPKLLKWPKEKIRERADELLALVGLDPAEFADRYPHELSGGQQQRVGVARALAADPPL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 162 LLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEFVASFV 241
Cdd:cd03295  157 LLMDEPFGALDPITRDQLQEEFKRLQQELGKTIVFVTHDIDEAFRLADRIAIMKNGEIVQVGTPDEILRSPANDFVAEFV 236


                 ....*.
gi 727180512 242 GQDRTL 247
Cdd:cd03295  237 GADRLL 242

proV

TIGR01186

glycine betaine/L-proline transport ATP binding subunit; This model describes the glycine ...

21-371

1.44e-108

Pssm-ID: 130254 [Multi-domain] Cd Length: 363 Bit Score: 322.57 E-value: 1.44e-108

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   21 AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSL----RRKIGYVIQQIGLFPNMT 96
Cdd:TIGR01186   8 GVNDADLAIAKGEIFVIMGLSGSGKSTTVRMLNRLIEPTAGQIFIDGENIMKQSPVELrevrRKKIGMVFQQFALFPHMT 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   97 IEENITVVPRMLGWDKKRCHARAEELMSMVALDpkRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINR 176
Cdd:TIGR01186  88 ILQNTSLGPELLGWPEQERKEKALELLKLVGLE--EYEHRYPDELSGGMQQRVGLARALAAEPDILLMDEAFSALDPLIR 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  177 ETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEFVASFVGQDRTLKRLllvQAG 256
Cdd:TIGR01186 166 DSMQDELKKLQATLQKTIVFITHDLDEAIRIGDRIVIMKAGEIVQVGTPDEILRNPANEYVEEFIGKVDLSQVF---DAE 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  257 DVAGQQET--VTVRRETPLVEAFGLMDDIDARSVTVVDADGKPLGYVK---RREARGAPGVCADSLHRFRVTARAEENLR 331
Cdd:TIGR01186 243 RIAQRMNTgpITKTADKGPRSALQLMRDERVDSLYVVDRQNKLVGVVDvesIKQARKKAQGLQDVLIDDIYTVDAGTLLR 322

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 727180512  332 VVLSKLYEHNTSwMPIVDEDGRYSGEISQDYIADYLSSGR 371
Cdd:TIGR01186 323 ETVRKVLKAGIK-VPVVDEDQRLVGIVTRGSLVDALYDSR 361

ProV

COG4175

ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and ...

21-361

5.54e-107

ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism];

Pssm-ID: 443334 [Multi-domain] Cd Length: 389 Bit Score: 319.36 E-value: 5.54e-107

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  21 AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSL----RRKIGYVIQQIGLFPNMT 96
Cdd:COG4175   42 GVNDASFDVEEGEIFVIMGLSGSGKSTLVRCLNRLIEPTAGEVLIDGEDITKLSKKELrelrRKKMSMVFQHFALLPHRT 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  97 IEENITVVPRMLGWDKKRCHARAEELMSMVALDPkrFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINR 176
Cdd:COG4175  122 VLENVAFGLEIQGVPKAERRERAREALELVGLAG--WEDSYPDELSGGMQQRVGLARALATDPDILLMDEAFSALDPLIR 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 177 ETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEFVASFV-GQDRTlkRLLlvQA 255
Cdd:COG4175  200 REMQDELLELQAKLKKTIVFITHDLDEALRLGDRIAIMKDGRIVQIGTPEEILTNPANDYVADFVeDVDRS--KVL--TA 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 256 GDVAGQQETVTVRRETPLVeAFGLMDDIDARSVTVVDADGKPLGYVKRREARGA---PGVCADSLHRFRVTARAEENLRV 332
Cdd:COG4175  276 GSVMRPPEAVVSEKDGPRV-ALRRMREEGISSLYVVDRDRRLLGVVTADDALEAvkgEKDLEEILLTDVPTVSPDTPLRD 354

                        330       340
                 ....*....|....*....|....*....
gi 727180512 333 VLSKLYEHNTSwMPIVDEDGRYSGEISQD 361
Cdd:COG4175  355 LLPLVAESPYP-LAVVDEDGRLLGVISRG 382

PotA

COG3842

ABC-type Fe3+/spermidine/putrescine transport systems, ATPase component [Amino acid transport ...

1-243

2.55e-98

ABC-type Fe3+/spermidine/putrescine transport systems, ATPase component [Amino acid transport and metabolism];

Pssm-ID: 443052 [Multi-domain] Cd Length: 353 Bit Score: 295.85 E-value: 2.55e-98

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqknGTpFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALdtVSLRR 80
Cdd:COG3842    5 ALELENVSKRY----GD-VTALDDVSLSIEPGEFVALLGPSGCGKTTLLRMIAGFETPDSGRILLDGRDVTGL--PPEKR 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPkrFLHRYPKEMSGGQQQRIGVIRALAADPP 160
Cdd:COG3842   78 NVGMVFQDYALFPHLTVAENVAFGLRMRGVPKAEIRARVAELLELVGLEG--LADRYPHQLSGGQQQRVALARALAPEPR 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 161 VLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEFVASF 240
Cdd:COG3842  156 VLLLDEPLSALDAKLREEMREELRRLQRELGITFIYVTHDQEEALALADRIAVMNDGRIEQVGTPEEIYERPATRFVADF 235


                 ...
gi 727180512 241 VGQ 243
Cdd:COG3842  236 IGE 238

ABC_Pro_Gly_Betaine

cd03294

ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; This ...

2-246

1.24e-91

ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporters is the obligatory coupling of ATP hydrolysis to substrate translocation. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213261 [Multi-domain] Cd Length: 269 Bit Score: 276.06 E-value: 1.24e-91

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQF---------MQKNGTPFN----------AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGT 62
Cdd:cd03294    1 IKIKGLYKIFgknpqkafkLLAKGKSKEeilkktgqtvGVNDVSLDVREGEIFVIMGLSGSGKSTLLRCINRLIEPTSGK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  63 ILINGEDTSALDTVSL----RRKIGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALdpKRFLHRYP 138
Cdd:cd03294   81 VLIDGQDIAAMSRKELrelrRKKISMVFQSFALLPHRTVLENVAFGLEVQGVPRAEREERAAEALELVGL--EGWEHKYP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 139 KEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGK 218
Cdd:cd03294  159 DELSGGMQQRVGLARALAVDPDILLMDEAFSALDPLIRREMQDELLRLQAELQKTIVFITHDLDEALRLGDRIAIMKDGR 238

                        250       260
                 ....*....|....*....|....*....
gi 727180512 219 IVQNASADELLARPANEFVASFV-GQDRT 246
Cdd:cd03294  239 LVQVGTPEEILTNPANDYVREFFrGVDRA 267

TauB

COG1116

ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion ...

1-220

7.25e-89

ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism];

Pssm-ID: 440733 [Multi-domain] Cd Length: 260 Bit Score: 268.50 E-value: 7.25e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQKNGtPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDtvslrR 80
Cdd:COG1116    7 ALELRGVSKRFPTGGG-GVTALDDVSLTVAAGEFVALVGPSGCGKSTLLRLIAGLEKPTSGEVLVDGKPVTGPG-----P 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPkrFLHRYPKEMSGGQQQRIGVIRALAADPP 160
Cdd:COG1116   81 DRGVVFQEPALLPWLTVLDNVALGLELRGVPKAERRERARELLELVGLAG--FEDAYPHQLSGGMRQRVAIARALANDPE 158

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727180512 161 VLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVF--RQGKIV 220
Cdd:COG1116  159 VLLMDEPFGALDALTRERLQDELLRLWQETGKTVLFVTHDVDEAVFLADRVVVLsaRPGRIV 220

ABC_NrtD_SsuB_transporters

cd03293

ATP-binding cassette domain of the nitrate and sulfonate transporters; NrtD and SsuB are the ...

2-221

1.14e-86

ATP-binding cassette domain of the nitrate and sulfonate transporters; NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213260 [Multi-domain] Cd Length: 220 Bit Score: 261.64 E-value: 1.14e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFmQKNGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALdtvslRRK 81
Cdd:cd03293    1 LEVRNVSKTY-GGGGGAVTALEDISLSVEEGEFVALVGPSGCGKSTLLRIIAGLERPTSGEVLVDGEPVTGP-----GPD 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALdpKRFLHRYPKEMSGGQQQRIGVIRALAADPPV 161
Cdd:cd03293   75 RGYVFQQDALLPWLTVLDNVALGLELQGVPKAEARERAEELLELVGL--SGFENAYPHQLSGGMRQRVALARALAVDPDV 152

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727180512 162 LLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVF--RQGKIVQ 221
Cdd:cd03293  153 LLLDEPFSALDALTREQLQEELLDIWRETGKTVLLVTHDIDEAVFLADRVVVLsaRPGRIVA 214

ABC_Carb_Solutes_like

cd03259

ATP-binding cassette domain of the carbohydrate and solute transporters-like; This family is ...

2-221

3.18e-86

ATP-binding cassette domain of the carbohydrate and solute transporters-like; This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213226 [Multi-domain] Cd Length: 213 Bit Score: 260.14 E-value: 3.18e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFmqkNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVslRRK 81
Cdd:cd03259    1 LELKGLSKTY---GSVR--ALDDLSLTVEPGEFLALLGPSGCGKTTLLRLIAGLERPDSGEILIDGRDVTGVPPE--RRN 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPkrFLHRYPKEMSGGQQQRIGVIRALAADPPV 161
Cdd:cd03259   74 IGMVFQDYALFPHLTVAENIAFGLKLRGVPKAEIRARVRELLELVGLEG--LLNRYPHELSGGQQQRVALARALAREPSL 151

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 162 LLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQ 221
Cdd:cd03259  152 LLLDEPLSALDAKLREELREELKELQRELGITTIYVTHDQEEALALADRIAVMNEGRIVQ 211

MalK

COG3839

ABC-type sugar transport system, ATPase component MalK [Carbohydrate transport and metabolism]; ...

1-242

1.27e-85

ABC-type sugar transport system, ATPase component MalK [Carbohydrate transport and metabolism];

Pssm-ID: 443050 [Multi-domain] Cd Length: 352 Bit Score: 263.47 E-value: 1.27e-85

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqkNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVslRR 80
Cdd:COG3839    3 SLELENVSKSY---GGVE--ALKDIDLDIEDGEFLVLLGPSGCGKSTLLRMIAGLEDPTSGEILIGGRDVTDLPPK--DR 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPkrFLHRYPKEMSGGQQQRIGVIRALAADPP 160
Cdd:COG3839   76 NIAMVFQSYALYPHMTVYENIAFPLKLRKVPKAEIDRRVREAAELLGLED--LLDRKPKQLSGGQRQRVALGRALVREPK 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 161 VLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEFVASF 240
Cdd:COG3839  154 VFLLDEPLSNLDAKLRVEMRAEIKRLHRRLGTTTIYVTHDQVEAMTLADRIAVMNDGRIQQVGTPEELYDRPANLFVAGF 233


                 ..
gi 727180512 241 VG 242
Cdd:COG3839  234 IG 235

CysA

COG1118

ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and ...

2-242

1.35e-84

ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism];

Pssm-ID: 440735 [Multi-domain] Cd Length: 348 Bit Score: 260.85 E-value: 1.35e-84

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFMQkngtpFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSAlDTVSLRRK 81
Cdd:COG1118    3 IEVRNISKRFGS-----FTLLDDVSLEIASGELVALLGPSGSGKTTLLRIIAGLETPDSGRIVLNGRDLFT-NLPPRERR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPkrFLHRYPKEMSGGQQQRIGVIRALAADPPV 161
Cdd:COG1118   77 VGFVFQHYALFPHMTVAENIAFGLRVRPPSKAEIRARVEELLELVQLEG--LADRYPSQLSGGQRQRVALARALAVEPEV 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 162 LLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEFVASFV 241
Cdd:COG1118  155 LLLDEPFGALDAKVRKELRRWLRRLHDELGGTTVFVTHDQEEALELADRVVVMNQGRIEQVGTPDEVYDRPATPFVARFL 234


                 .
gi 727180512 242 G 242
Cdd:COG1118  235 G 235

ABC_PotA_N

cd03300

ATP-binding cassette domain of the polyamine transporter; PotA is an ABC-type transporter and ...

2-242

3.31e-79

ATP-binding cassette domain of the polyamine transporter; PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required for homodimerization with PotA and heterdimerization with PotB. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213267 [Multi-domain] Cd Length: 232 Bit Score: 242.91 E-value: 3.31e-79

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFMQkngtpFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTvsLRRK 81
Cdd:cd03300    1 IELENVSKFYGG-----FVALDGVSLDIKEGEFFTLLGPSGCGKTTLLRLIAGFETPTSGEILLDGKDITNLPP--HKRP 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDpkRFLHRYPKEMSGGQQQRIGVIRALAADPPV 161
Cdd:cd03300   74 VNTVFQNYALFPHLTVFENIAFGLRLKKLPKAEIKERVAEALDLVQLE--GYANRKPSQLSGGQQQRVAIARALVNEPKV 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 162 LLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEFVASFV 241
Cdd:cd03300  152 LLLDEPLGALDLKLRKDMQLELKRLQKELGITFVFVTHDQEEALTMSDRIAVMNKGKIQQIGTPEEIYEEPANRFVADFI 231


                 .
gi 727180512 242 G 242
Cdd:cd03300  232 G 232

CcmA

COG1131

ABC-type multidrug transport system, ATPase component [Defense mechanisms];

2-231

1.03e-76

ABC-type multidrug transport system, ATPase component [Defense mechanisms];

Pssm-ID: 440746 [Multi-domain] Cd Length: 236 Bit Score: 236.50 E-value: 1.03e-76

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFmqkngTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSAlDTVSLRRK 81
Cdd:COG1131    1 IEVRGLTKRY-----GDKTALDGVSLTVEPGEIFGLLGPNGAGKTTTIRMLLGLLRPTSGEVRVLGEDVAR-DPAEVRRR 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIGVIRALAADPPV 161
Cdd:COG1131   75 IGYVPQEPALYPDLTVRENLRFFARLYGLPRKEARERIDELLELFGLTDAA--DRKVGTLSGGMKQRLGLALALLHDPEL 152

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727180512 162 LLMDEPFGAVDPINRetiqNEFLDMQRQLK---KTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLAR 231
Cdd:COG1131  153 LILDEPTSGLDPEAR----RELWELLRELAaegKTVLLSTHYLEEAERLCDRVAIIDKGRIVADGTPDELKAR 221

GsiA

COG1123

ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain ...

1-235

2.69e-76

ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain [Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 440740 [Multi-domain] Cd Length: 514 Bit Score: 244.43 E-value: 2.69e-76

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQKNGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVS--- 77
Cdd:COG1123  260 LLEVRNLSKRYPVRGKGGVRAVDDVSLTLRRGETLGLVGESGSGKSTLARLLLGLLRPTSGSILFDGKDLTKLSRRSlre 339

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  78 LRRKIGYVIQ----QigLFPNMTIEENITVVPRMLGW-DKKRCHARAEELMSMVALDPkRFLHRYPKEMSGGQQQRIGVI 152
Cdd:COG1123  340 LRRRVQMVFQdpysS--LNPRMTVGDIIAEPLRLHGLlSRAERRERVAELLERVGLPP-DLADRYPHELSGGQRQRVAIA 416

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 153 RALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARP 232
Cdd:COG1123  417 RALALEPKLLILDEPTSALDVSVQAQILNLLRDLQRELGLTYLFISHDLAVVRYIADRVAVMYDGRIVEDGPTEEVFANP 496


                 ...
gi 727180512 233 ANE 235
Cdd:COG1123  497 QHP 499

PhnT2

TIGR03265

putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; This ABC transporter ...

2-327

5.45e-74

putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; This ABC transporter ATP-binding protein is found in a number of genomes in operon-like contexts strongly suggesting a substrate specificity for 2-aminoethylphosphonate (2-AEP). The characterized PhnSTUV system is absent in the genomes in which this system is found. These genomes encode systems for the catabolism of 2-AEP, making the need for a 2-AEP-specific transporter likely. [Transport and binding proteins, Amino acids, peptides and amines]

Pssm-ID: 274496 [Multi-domain] Cd Length: 353 Bit Score: 233.78 E-value: 5.45e-74

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512    2 IKLENLTKQFMQkngtpFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDtvSLRRK 81
Cdd:TIGR03265   5 LSIDNIRKRFGA-----FTALKDISLSVKKGEFVCLLGPSGCGKTTLLRIIAGLERQTAGTIYQGGRDITRLP--PQKRD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   82 IGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIGVIRALAADPPV 161
Cdd:TIGR03265  78 YGIVFQSYALFPNLTVADNIAYGLKNRGMGRAEVAERVAELLDLVGLPGSE--RKYPGQLSGGQQQRVALARALATSPGL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  162 LLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEFVASFV 241
Cdd:TIGR03265 156 LLLDEPLSALDARVREHLRTEIRQLQRRLGVTTIMVTHDQEEALSMADRIVVMNHGVIEQVGTPQEIYRHPATPFVADFV 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  242 GQDRTLKRLLLVQAGDVAGQQETVTVRRETPLVEAFGLM---DDIdaRSVTVVDADGKPLGYVKRREARGApgvcadslh 318
Cdd:TIGR03265 236 GEVNWLPGTRGGGSRARVGGLTLACAPGLAQPGASVRLAvrpEDI--RVSPAGNAANLLLARVEDMEFLGA--------- 304


                  ....*....
gi 727180512  319 RFRVTARAE 327
Cdd:TIGR03265 305 FYRLRLRLE 313

ABC_choXWV_ATP

TIGR03415

choline ABC transporter, ATP-binding protein; Members of this protein family are the ...

21-363

3.51e-73

choline ABC transporter, ATP-binding protein; Members of this protein family are the ATP-binding subunit of a three-protein transporter. This family belongs, more broadly, to the family of proline and glycine-betaine transporters, but members have been identified by direct characterization and by bioinformatic means as choline transporters. Many species have several closely-related members of this family, probably with variable abilities to act additionally on related quaternary amines. [Transport and binding proteins, Amino acids, peptides and amines]

Pssm-ID: 188317 [Multi-domain] Cd Length: 382 Bit Score: 232.75 E-value: 3.51e-73

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   21 AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTS----ALDTVSLRR----KIGYVIQQIGLF 92
Cdd:TIGR03415  39 GVHNASLDIEEGEICVLMGLSGSGKSTLLRAVNGLNPVSRGSVLVKDGDGSvdvaNCDAATLRRlrthRVSMVFQQFALL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   93 PNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVD 172
Cdd:TIGR03415 119 PWRTVEENVAFGLEMQGMPKAERRKRVDEQLELVGLAQWA--DRKPGELSGGMQQRVGLARAFATEAPILLMDEPFSALD 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  173 PINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEFVASFVGQDRTLKRLLl 252
Cdd:TIGR03415 197 PLIRTQLQDELLELQSKLKKTIVFVSHDLDEALKIGNRIAIMEGGRIIQHGTPEEIVLNPANDYVADFVAHTNPLNVLT- 275

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  253 vqAGDVAGQQETVTvRRETPLVEAFGLMDDIDARSVTVVDADGKPlgyvkrREARGAPGVCADSLHRFRVTARAEENLRV 332
Cdd:TIGR03415 276 --ARDLMRPLTTLE-KVDGEWCVSKRYDTWLKTADKQVRRAAAGL------PVAAWAAEQEVESLEKLPTVINPDTPMRD 346

                         330       340       350
                  ....*....|....*....|....*....|.
gi 727180512  333 VLSKLYEHNTSwmPIVDEDGRYSGEISQDYI 363
Cdd:TIGR03415 347 VLAARHRTGGA--ILLVENGRIVGVIGDQNI 375

MlaF

COG1127

ATPase subunit MlaF of the ABC-type intermembrane phospholipid transporter Mla [Cell wall ...

1-241

7.65e-73

ATPase subunit MlaF of the ABC-type intermembrane phospholipid transporter Mla [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 440744 [Multi-domain] Cd Length: 241 Bit Score: 226.78 E-value: 7.65e-73

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqknGTpfNAV-DNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDT---V 76
Cdd:COG1127    5 MIEVRNLTKSF----GD--RVVlDGVSLDVPRGEILAIIGGSGSGKSVLLKLIIGLLRPDSGEILVDGQDITGLSEkelY 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  77 SLRRKIGYVIQQIGLFPNMTIEENITVVPRMLG-WDKKRCHARAEELMSMVALDPkrFLHRYPKEMSGGQQQRIGVIRAL 155
Cdd:COG1127   79 ELRRRIGMLFQGGALFDSLTVFENVAFPLREHTdLSEAEIRELVLEKLELVGLPG--AADKMPSELSGGMRKRVALARAL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 156 AADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPaNE 235
Cdd:COG1127  157 ALDPEILLYDEPTAGLDPITSAVIDELIRELRDELGLTSVVVTHDLDSAFAIADRVAVLADGKIIAEGTPEELLASD-DP 235


                 ....*.
gi 727180512 236 FVASFV 241
Cdd:COG1127  236 WVRQFL 241

GlnQ

COG1126

ABC-type polar amino acid transport system, ATPase component [Amino acid transport and ...

1-243

1.80e-72

ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism];

Pssm-ID: 440743 [Multi-domain] Cd Length: 239 Bit Score: 225.64 E-value: 1.80e-72

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqknGTpFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGED--TSALDTVSL 78
Cdd:COG1126    1 MIEIENLHKSF----GD-LEVLKGISLDVEKGEVVVIIGPSGSGKSTLLRCINLLEEPDSGTITVDGEDltDSKKDINKL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  79 RRKIGYVIQQIGLFPNMTIEENITVVPRM-LGWDKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIGVIRALAA 157
Cdd:COG1126   76 RRKVGMVFQQFNLFPHLTVLENVTLAPIKvKKMSKAEAEERAMELLERVGLADKA--DAYPAQLSGGQQQRVAIARALAM 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 158 DPPVLLMDEPFGAVDPinrETIqNEFLDMQRQLKK---TVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPAN 234
Cdd:COG1126  154 EPKVMLFDEPTSALDP---ELV-GEVLDVMRDLAKegmTMVVVTHEMGFAREVADRVVFMDGGRIVEEGPPEEFFENPQH 229


                 ....*....
gi 727180512 235 EFVASFVGQ 243
Cdd:COG1126  230 ERTRAFLSK 238

ABC_MJ0796_LolCDE_FtsE

cd03255

ATP-binding cassette domain of the transporters involved in export of lipoprotein and ...

2-219

8.48e-72

ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and Cell division ATP-binding protein FtsE; This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. The FtsEX complex resembles an ABC transporter, where FtsE is the ATPase and the membrane subunit FtsX resembles a permease subunit. But rather than transporting any substrate, the complex acts in cell division by undergoing conformational changes that alter the activity of cell wall hydrolases located outside the plasma membrane. The complex is widely conserved in bacteria, but also extremely divergent in sequence between different lineages. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.

Pssm-ID: 213222 [Multi-domain] Cd Length: 218 Bit Score: 223.52 E-value: 8.48e-72

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFmQKNGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSL--- 78
Cdd:cd03255    1 IELKNLSKTY-GGGGEKVQALKGVSLSIEKGEFVAIVGPSGSGKSTLLNILGGLDRPTSGEVRVDGTDISKLSEKELaaf 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  79 -RRKIGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALdpKRFLHRYPKEMSGGQQQRIGVIRALAA 157
Cdd:cd03255   80 rRRHIGFVFQSFNLLPDLTALENVELPLLLAGVPKKERRERAEELLERVGL--GDRLNHYPSELSGGQQQRVAIARALAN 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727180512 158 DPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEAlKLGDRIAVFRQGKI 219
Cdd:cd03255  158 DPKIILADEPTGNLDSETGKEVMELLRELNKEAGTTIVVVTHDPELA-EYADRIIELRDGKI 218

ABC_CysA_sulfate_importer

cd03296

ATP-binding cassette domain of the sulfate transporter; Part of the ABC transporter complex ...

2-243

1.58e-71

ATP-binding cassette domain of the sulfate transporter; Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a solute-binding protein (cysP). ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213263 [Multi-domain] Cd Length: 239 Bit Score: 223.37 E-value: 1.58e-71

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFMQkngtpFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTvsLRRK 81
Cdd:cd03296    3 IEVRNVSKRFGD-----FVALDDVSLDIPSGELVALLGPSGSGKTTLLRLIAGLERPDSGTILFGGEDATDVPV--QERN 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPNMTIEENIT----VVPRMLGWDKKRCHARAEELMSMVALDpkRFLHRYPKEMSGGQQQRIGVIRALAA 157
Cdd:cd03296   76 VGFVFQHYALFRHMTVFDNVAfglrVKPRSERPPEAEIRAKVHELLKLVQLD--WLADRYPAQLSGGQRQRVALARALAV 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 158 DPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEFV 237
Cdd:cd03296  154 EPKVLLLDEPFGALDAKVRKELRRWLRRLHDELHVTTVFVTHDQEEALEVADRVVVMNKGRIEQVGTPDEVYDHPASPFV 233


                 ....*.
gi 727180512 238 ASFVGQ 243
Cdd:cd03296  234 YSFLGE 239

LolD

COG1136

ABC-type lipoprotein export system, ATPase component [Cell wall/membrane/envelope biogenesis];

1-222

1.83e-70

ABC-type lipoprotein export system, ATPase component [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 440751 [Multi-domain] Cd Length: 227 Bit Score: 220.30 E-value: 1.83e-70

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmQKNGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSL-- 78
Cdd:COG1136    4 LLELRNLTKSY-GTGEGEVTALRGVSLSIEAGEFVAIVGPSGSGKSTLLNILGGLDRPTSGEVLIDGQDISSLSERELar 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  79 --RRKIGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKrfLHRYPKEMSGGQQQRIGVIRALA 156
Cdd:COG1136   83 lrRRHIGFVFQFFNLLPELTALENVALPLLLAGVSRKERRERARELLERVGLGDR--LDHRPSQLSGGQQQRVAIARALV 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727180512 157 ADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDiDEALKLGDRIAVFRQGKIVQN 222
Cdd:COG1136  161 NRPKLILADEPTGNLDSKTGEEVLELLRELNRELGTTIVMVTHD-PELAARADRVIRLRDGRIVSD 225

ABC_Class3

cd03229

ATP-binding cassette domain of the binding protein-dependent transport systems; This class is ...

2-218

6.73e-69

ATP-binding cassette domain of the binding protein-dependent transport systems; This class is comprised of all BPD (Binding Protein Dependent) systems that are largely represented in archaea and eubacteria and are primarily involved in scavenging solutes from the environment. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213196 [Multi-domain] Cd Length: 178 Bit Score: 214.36 E-value: 6.73e-69

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFMQKNgtpfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALD--TVSLR 79
Cdd:cd03229    1 LELKNVSKRYGQKT-----VLNDVSLNIEAGEIVALLGPSGSGKSTLLRCIAGLEEPDSGSILIDGEDLTDLEdeLPPLR 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  80 RKIGYVIQQIGLFPNMTIEENITvvprmlgwdkkrcharaeelmsmvaldpkrflhrYPkeMSGGQQQRIGVIRALAADP 159
Cdd:cd03229   76 RRIGMVFQDFALFPHLTVLENIA----------------------------------LG--LSGGQQQRVALARALAMDP 119

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 727180512 160 PVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGK 218
Cdd:cd03229  120 DVLLLDEPTSALDPITRREVRALLKSLQAQLGITVVLVTHDLDEAARLADRVVVLRDGK 178

3a0106s01

TIGR00968

sulfate ABC transporter, ATP-binding protein; [Transport and binding proteins, Anions]

2-247

2.62e-68

sulfate ABC transporter, ATP-binding protein; [Transport and binding proteins, Anions]

Pssm-ID: 130041 [Multi-domain] Cd Length: 237 Bit Score: 215.05 E-value: 2.62e-68

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512    2 IKLENLTKQFMQkngtpFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTvsLRRK 81
Cdd:TIGR00968   1 IEIANISKRFGS-----FQALDDVNLEVPTGSLVALLGPSGSGKSTLLRIIAGLEQPDSGRIRLNGQDATRVHA--RDRK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   82 IGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDpkRFLHRYPKEMSGGQQQRIGVIRALAADPPV 161
Cdd:TIGR00968  74 IGFVFQHYALFKHLTVRDNIAFGLEIRKHPKAKIKARVEELLELVQLE--GLGDRYPNQLSGGQRQRVALARALAVEPQV 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  162 LLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEFVASFV 241
Cdd:TIGR00968 152 LLLDEPFGALDAKVRKELRSWLRKLHDEVHVTTVFVTHDQEEAMEVADRIVVMSNGKIEQIGSPDEVYDHPANPFVMSFL 231


                  ....*.
gi 727180512  242 GQDRTL 247
Cdd:TIGR00968 232 GEVNVL 237

ABC_ModC_like

cd03299

ATP-binding cassette domain similar to the molybdate transporter; Archaeal protein closely ...

2-242

1.58e-67

ATP-binding cassette domain similar to the molybdate transporter; Archaeal protein closely related to ModC. ModC is an ABC-type transporter and the ATPase component of a molybdate transport system that also includes the periplasmic binding protein ModA and the membrane protein ModB. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213266 [Multi-domain] Cd Length: 235 Bit Score: 212.97 E-value: 1.58e-67

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKqfmqkNGTPFNaVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVslRRK 81
Cdd:cd03299    1 LKVENLSK-----DWKEFK-LKNVSLEVERGDYFVILGPTGSGKSVLLETIAGFIKPDSGKILLNGKDITNLPPE--KRD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDpkRFLHRYPKEMSGGQQQRIGVIRALAADPPV 161
Cdd:cd03299   73 ISYVPQNYALFPHMTVYKNIAYGLKKRKVDKKEIERKVLEIAEMLGID--HLLNRKPETLSGGEQQRVAIARALVVNPKI 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 162 LLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEFVASFV 241
Cdd:cd03299  151 LLLDEPFSALDVRTKEKLREELKKIRKEFGVTVLHVTHDFEEAWALADKVAIMLNGKLIQVGKPEEVFKKPKNEFVAEFL 230


                 .
gi 727180512 242 G 242
Cdd:cd03299  231 G 231

AbcC

COG1135

ABC-type methionine transport system, ATPase component [Amino acid transport and metabolism];

1-243

8.47e-67

ABC-type methionine transport system, ATPase component [Amino acid transport and metabolism];

Pssm-ID: 440750 [Multi-domain] Cd Length: 339 Bit Score: 214.56 E-value: 8.47e-67

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQKNGtPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSL-- 78
Cdd:COG1135    1 MIELENLSKTFPTKGG-PVTALDDVSLTIEKGEIFGIIGYSGAGKSTLIRCINLLERPTSGSVLVDGVDLTALSERELra 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  79 -RRKIGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIGVIRALAA 157
Cdd:COG1135   80 aRRKIGMIFQHFNLLSSRTVAENVALPLEIAGVPKAEIRKRVAELLELVGLSDKA--DAYPSQLSGGQKQRVGIARALAN 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 158 DPPVLLMDEPFGAVDPinrETIQN--EFL-DMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPAN 234
Cdd:COG1135  158 NPKVLLCDEATSALDP---ETTRSilDLLkDINRELGLTIVLITHEMDVVRRICDRVAVLENGRIVEQGPVLDVFANPQS 234


                 ....*....
gi 727180512 235 EFVASFVGQ 243
Cdd:COG1135  235 ELTRRFLPT 243

ABC_MalK_N

cd03301

The N-terminal ATPase domain of the maltose transporter, MalK; ATP binding cassette (ABC) ...

2-221

4.79e-66

The N-terminal ATPase domain of the maltose transporter, MalK; ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two transmembrane-spanning domains (TMDs) or subunits and two nucleotide binding domains (NBDs) or subunits that couple transport to the hydrolysis of ATP. In the maltose transport system, the periplasmic maltose binding protein (MBP) stimulates the ATPase activity of the membrane-associated transporter, which consists of two transmembrane subunits, MalF and MalG, and two copies of the ATP binding subunit, MalK, and becomes tightly bound to the transporter in the catalytic transition state, ensuring that maltose is passed to the transporter as ATP is hydrolyzed.

Pssm-ID: 213268 [Multi-domain] Cd Length: 213 Bit Score: 208.65 E-value: 4.79e-66

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFmqkngTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSalDTVSLRRK 81
Cdd:cd03301    1 VELENVTKRF-----GNVTALDDLNLDIADGEFVVLLGPSGCGKTTTLRMIAGLEEPTSGRIYIGGRDVT--DLPPKDRD 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDpkRFLHRYPKEMSGGQQQRIGVIRALAADPPV 161
Cdd:cd03301   74 IAMVFQNYALYPHMTVYDNIAFGLKLRKVPKDEIDERVREVAELLQIE--HLLDRKPKQLSGGQRQRVALGRAIVREPKV 151

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 162 LLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQ 221
Cdd:cd03301  152 FLMDEPLSNLDAKLRVQMRAELKRLQQRLGTTTIYVTHDQVEAMTMADRIAVMNDGQIQQ 211

ABC_NikE_OppD_transporters

cd03257

ATP-binding cassette domain of nickel/oligopeptides specific transporters; The ABC transporter ...

1-220

8.21e-66

ATP-binding cassette domain of nickel/oligopeptides specific transporters; The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane components (NikB and NikC), and two ATPase (NikD and NikE). The NikABCDE transporter is synthesized under anaerobic conditions to meet the increased demand for nickel resulting from hydrogenase synthesis. The molecular mechanism of nickel uptake in many bacteria and most archaea is not known. Many other members of this ABC family are also involved in the uptake of dipeptides and oligopeptides. The oligopeptide transport system (Opp) is a five-component ABC transport composed of a membrane-anchored substrate binding proteins (SRP), OppA, two transmembrane proteins, OppB and OppC, and two ATP-binding domains, OppD and OppF.

Pssm-ID: 213224 [Multi-domain] Cd Length: 228 Bit Score: 208.51 E-value: 8.21e-66

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQKNGtPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSL-- 78
Cdd:cd03257    1 LLEVKNLSVSFPTGGG-SVKALDDVSFSIKKGETLGLVGESGSGKSTLARAILGLLKPTSGSIIFDGKDLLKLSRRLRki 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  79 -RRKIGYVIQQIG--LFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVAL-DPKRFLHRYPKEMSGGQQQRIGVIRA 154
Cdd:cd03257   80 rRKEIQMVFQDPMssLNPRMTIGEQIAEPLRIHGKLSKKEARKEAVLLLLVGVgLPEEVLNRYPHELSGGQRQRVAIARA 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727180512 155 LAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIV 220
Cdd:cd03257  160 LALNPKLLIADEPTSALDVSVQAQILDLLKKLQEELGLTLLFITHDLGVVAKIADRVAVMYAGKIV 225

NatA

COG4555

ABC-type Na+ transport system, ATPase component NatA [Energy production and conversion, ...

1-235

2.21e-65

ABC-type Na+ transport system, ATPase component NatA [Energy production and conversion, Inorganic ion transport and metabolism];

Pssm-ID: 443618 [Multi-domain] Cd Length: 243 Bit Score: 207.79 E-value: 2.21e-65

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQKNgtpfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDtSALDTVSLRR 80
Cdd:COG4555    1 MIEVENLSKKYGKVP-----ALKDVSFTAKDGEITGLLGPNGAGKTTLLRMLAGLLKPDSGSILIDGED-VRKEPREARR 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPkrFLHRYPKEMSGGQQQRIGVIRALAADPP 160
Cdd:COG4555   75 QIGVLPDERGLYDRLTVRENIRYFAELYGLFDEELKKRIEELIELLGLEE--FLDRRVGELSTGMKKKVALARALVHDPK 152

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727180512 161 VLLMDEPFGAVDPINRETIQNEFLDMqRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANE 235
Cdd:COG4555  153 VLLLDEPTNGLDVMARRLLREILRAL-KKEGKTVLFSSHIMQEVEALCDRVVILHKGKVVAQGSLDELREEIGEE 226

ABC_MetN_methionine_transporter

cd03258

ATP-binding cassette domain of methionine transporter; MetN (also known as YusC) is an ...

1-232

3.07e-64

ATP-binding cassette domain of methionine transporter; MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213225 [Multi-domain] Cd Length: 233 Bit Score: 204.74 E-value: 3.07e-64

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQKNGTpFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSL-- 78
Cdd:cd03258    1 MIELKNVSKVFGDTGGK-VTALKDVSLSVPKGEIFGIIGRSGAGKSTLIRCINGLERPTSGSVLVDGTDLTLLSGKELrk 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  79 -RRKIGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIGVIRALAA 157
Cdd:cd03258   80 aRRRIGMIFQHFNLLSSRTVFENVALPLEIAGVPKAEIEERVLELLELVGLEDKA--DAYPAQLSGGQKQRVGIARALAN 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727180512 158 DPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARP 232
Cdd:cd03258  158 NPKVLLCDEATSALDPETTQSILALLRDINRELGLTIVLITHEMEVVKRICDRVAVMEKGEVVEEGTVEEVFANP 232

ABC_HisP_GlnQ

cd03262

ATP-binding cassette domain of the histidine and glutamine transporters; HisP and GlnQ are the ...

2-219

7.01e-64

ATP-binding cassette domain of the histidine and glutamine transporters; HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, respectively. Histidine permease is a multi-subunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP has properties intermediate between those of integral and peripheral membrane proteins and is accessible from both sides of the membrane, presumably by its interaction with HisQ and HisM. The two HisP subunits form a homodimer within the complex. The domain structure of the amino acid uptake systems is typical for prokaryotic extracellular solute binding protein-dependent uptake systems. All of the amino acid uptake systems also have at least one, and in a few cases, two extracellular solute binding proteins located in the periplasm of Gram-negative bacteria, or attached to the cell membrane of Gram-positive bacteria. The best-studied member of the PAAT (polar amino acid transport) family is the HisJQMP system of S. typhimurium, where HisJ is the extracellular solute binding proteins and HisP is the ABC protein.

Pssm-ID: 213229 [Multi-domain] Cd Length: 213 Bit Score: 202.76 E-value: 7.01e-64

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFmqkngTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGE--DTSALDTVSLR 79
Cdd:cd03262    1 IEIKNLHKSF-----GDFHVLKGIDLTVKKGEVVVIIGPSGSGKSTLLRCINLLEEPDSGTIIIDGLklTDDKKNINELR 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  80 RKIGYVIQQIGLFPNMTIEENITVVPR-MLGWDKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIGVIRALAAD 158
Cdd:cd03262   76 QKVGMVFQQFNLFPHLTVLENITLAPIkVKGMSKAEAEERALELLEKVGLADKA--DAYPAQLSGGQQQRVAIARALAMN 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 727180512 159 PPVLLMDEPFGAVDPinrETIqNEFLDMQRQLKK---TVMLVSHDIDEALKLGDRIAVFRQGKI 219
Cdd:cd03262  154 PKVMLFDEPTSALDP---ELV-GEVLDVMKDLAEegmTMVVVTHEMGFAREVADRVIFMDDGRI 213

potA

PRK09452

spermidine/putrescine ABC transporter ATP-binding protein PotA;

2-243

8.26e-64

spermidine/putrescine ABC transporter ATP-binding protein PotA;

Pssm-ID: 236523 [Multi-domain] Cd Length: 375 Bit Score: 208.26 E-value: 8.26e-64

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFmqkNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDtvSLRRK 81
Cdd:PRK09452  15 VELRGISKSF---DGKE--VISNLDLTINNGEFLTLLGPSGCGKTTVLRLIAGFETPDSGRIMLDGQDITHVP--AENRH 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDpkRFLHRYPKEMSGGQQQRIGVIRALAADPPV 161
Cdd:PRK09452  88 VNTVFQSYALFPHMTVFENVAFGLRMQKTPAAEITPRVMEALRMVQLE--EFAQRKPHQLSGGQQQRVAIARAVVNKPKV 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 162 LLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEFVASFV 241
Cdd:PRK09452 166 LLLDESLSALDYKLRKQMQNELKALQRKLGITFVFVTHDQEEALTMSDRIVVMRDGRIEQDGTPREIYEEPKNLFVARFI 245


                 ..
gi 727180512 242 GQ 243
Cdd:PRK09452 246 GE 247

ABC_Org_Solvent_Resistant

cd03261

ATP-binding cassette transport system involved in resistance to organic solvents; ABC ...

2-240

1.52e-63

ATP-binding cassette transport system involved in resistance to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213228 [Multi-domain] Cd Length: 235 Bit Score: 202.73 E-value: 1.52e-63

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFmqknGTpfNAV-DNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSAL---DTVS 77
Cdd:cd03261    1 IELRGLTKSF----GG--RTVlKGVDLDVRRGEILAIIGPSGSGKSTLLRLIVGLLRPDSGEVLIDGEDISGLseaELYR 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  78 LRRKIGYVIQQIGLFPNMTIEENITVVPRMLG-WDKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIGVIRALA 156
Cdd:cd03261   75 LRRRMGMLFQSGALFDSLTVFENVAFPLREHTrLSEEEIREIVLEKLEAVGLRGAE--DLYPAELSGGMKKRVALARALA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 157 ADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPaNEF 236
Cdd:cd03261  153 LDPELLLYDEPTAGLDPIASGVIDDLIRSLKKELGLTSIMVTHDLDTAFAIADRIAVLYDGKIVAEGTPEELRASD-DPL 231


                 ....
gi 727180512 237 VASF 240
Cdd:cd03261  232 VRQF 235

EcfA2

COG1122

Energy-coupling factor transporter ATP-binding protein EcfA2 [Inorganic ion transport and ...

2-232

3.91e-63

Energy-coupling factor transporter ATP-binding protein EcfA2 [Inorganic ion transport and metabolism, General function prediction only];

Pssm-ID: 440739 [Multi-domain] Cd Length: 230 Bit Score: 201.41 E-value: 3.91e-63

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFMqkNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRK 81
Cdd:COG1122    1 IELENLSFSYP--GGTP--ALDDVSLSIEKGEFVAIIGPNGSGKSTLLRLLNGLLKPTSGEVLVDGKDITKKNLRELRRK 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQ----QigLFpNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPkrFLHRYPKEMSGGQQQRIGVIRALAA 157
Cdd:COG1122   77 VGLVFQnpddQ--LF-APTVEEDVAFGPENLGLPREEIRERVEEALELVGLEH--LADRPPHELSGGQKQRVAIAGVLAM 151

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727180512 158 DPPVLLMDEPFGAVDPINRETIQNEFLDMQRQlKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARP 232
Cdd:COG1122  152 EPEVLVLDEPTAGLDPRGRRELLELLKRLNKE-GKTVIIVTHDLDLVAELADRVIVLDDGRIVADGTPREVFSDY 225

potA

TIGR01187

spermidine/putrescine ABC transporter ATP-binding subunit; This model describes spermidine ...

37-243

1.51e-62

spermidine/putrescine ABC transporter ATP-binding subunit; This model describes spermidine/putrescine ABC transporter, ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. Polyamines like spermidine and putrescine play vital role in cell proliferation, differentiation, and ion homeostasis. The concentration of polyamines within the cell are regulated by biosynthesis, degradation and transport (uptake and efflux included). [Transport and binding proteins, Amino acids, peptides and amines]

Pssm-ID: 162242 [Multi-domain] Cd Length: 325 Bit Score: 203.49 E-value: 1.51e-62

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   37 LLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSalDTVSLRRKIGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCH 116
Cdd:TIGR01187   1 LLGPSGCGKTTLLRLLAGFEQPDSGSIMLDGEDVT--NVPPHLRHINMVFQSYALFPHMTVEENVAFGLKMRKVPRAEIK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  117 ARAEELMSMVALdpKRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVML 196
Cdd:TIGR01187  79 PRVLEALRLVQL--EEFADRKPHQLSGGQQQRVALARALVFKPKILLLDEPLSALDKKLRDQMQLELKTIQEQLGITFVF 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 727180512  197 VSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEFVASFVGQ 243
Cdd:TIGR01187 157 VTHDQEEAMTMSDRIAIMRKGKIAQIGTPEEIYEEPANLFVARFIGE 203

ABC_PstB_phosphate_transporter

cd03260

ATP-binding cassette domain of the phosphate transport system; Phosphate uptake is of ...

2-228

9.20e-62

ATP-binding cassette domain of the phosphate transport system; Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein is a phosphate-binding protein located in the periplasmic space. PstA and PstC are hydrophobic and they form the transmembrane portion of the Pst system. PstB is the catalytic subunit, which couples the energy of ATP hydrolysis to the import of phosphate across cellular membranes through the Pst system, often referred as ABC-protein. PstB belongs to one of the largest superfamilies of proteins characterized by a highly conserved adenosine triphosphate (ATP) binding cassette (ABC), which is also a nucleotide binding domain (NBD).

Pssm-ID: 213227 [Multi-domain] Cd Length: 227 Bit Score: 197.79 E-value: 9.20e-62

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFmqkngTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIE-----PTGGTILINGEDTSALDT- 75
Cdd:cd03260    1 IELRDLNVYY-----GDKHALKDISLDIPKGEITALIGPSGCGKSTLLRLLNRLNDlipgaPDEGEVLLDGKDIYDLDVd 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  76 -VSLRRKIGYVIQQIGLFPnMTIEENITVVPRMLG-WDKKRCHARAEELMSMVALDP--KRFLHryPKEMSGGQQQRIGV 151
Cdd:cd03260   76 vLELRRRVGMVFQKPNPFP-GSIYDNVAYGLRLHGiKLKEELDERVEEALRKAALWDevKDRLH--ALGLSGGQQQRLCL 152

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 727180512 152 IRALAADPPVLLMDEPFGAVDPINRETIQneflDMQRQLKK--TVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADEL 228
Cdd:cd03260  153 ARALANEPEVLLLDEPTSALDPISTAKIE----ELIAELKKeyTIVIVTHNMQQAARVADRTAFLLNGRLVEFGPTEQI 227

PhnC

COG3638

ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and ...

1-228

2.94e-61

ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism];

Pssm-ID: 442855 [Multi-domain] Cd Length: 249 Bit Score: 197.20 E-value: 2.94e-61

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqKNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSL-- 78
Cdd:COG3638    2 MLELRNLSKRY--PGGTP--ALDDVSLEIERGEFVALIGPSGAGKSTLLRCLNGLVEPTSGEILVDGQDVTALRGRALrr 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  79 -RRKIGYVIQQIGLFPNMTIEENI--------TVVPRMLGWDKKRCHARAEELMSMVALDPKrfLHRYPKEMSGGQQQRI 149
Cdd:COG3638   78 lRRRIGMIFQQFNLVPRLSVLTNVlagrlgrtSTWRSLLGLFPPEDRERALEALERVGLADK--AYQRADQLSGGQQQRV 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 727180512 150 GVIRALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADEL 228
Cdd:COG3638  156 AIARALVQEPKLILADEPVASLDPKTARQVMDLLRRIAREDGITVVVNLHQVDLARRYADRIIGLRDGRVVFDGPPAEL 234

CBS_pair_ABC_OpuCA_assoc

cd04582

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found associated with ...

258-368

3.38e-61

Pssm-ID: 341359 [Multi-domain] Cd Length: 111 Bit Score: 192.22 E-value: 3.38e-61

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 258 VAGQQETVTVRRETPLVEAFGLMDDIDARSVTVVDADGKPLGYVKRREARGAPGVCADSLHRFRVTARAEENLRVVLSKL 337
Cdd:cd04582    1 EDAATPTPTVRPSTPLSDALGIMDDADSRYLVVVDADGRPLGYVTRRDARGASGTCGDFAHPFKATVPVDENLRVVLSRM 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 727180512 338 YEHNTSWMPIVDEDGRYSGEISQDYIADYLS 368
Cdd:cd04582   81 YEHNTSWLPVVDEDGRYAGEVTQDSIADYLS 111

ABC_DR_subfamily_A

cd03230

ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily ...

2-219

6.73e-61

ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; This family of ATP-binding proteins belongs to a multi-subunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding protein and one or two integral membrane proteins. Eukaryotic systems of the ABCA subfamily display ABC domains that are quite similar to this family. The ATP-binding domain shows the highest similarity between all members of the ABC transporter family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213197 [Multi-domain] Cd Length: 173 Bit Score: 193.77 E-value: 6.73e-61

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFmqknGTpFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSAlDTVSLRRK 81
Cdd:cd03230    1 IEVRNLSKRY----GK-KTALDDISLTVEKGEIYGLLGPNGAGKTTLIKIILGLLKPDSGEIKVLGKDIKK-EPEEVKRR 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPNMTIEENItvvprmlgwdkkrcharaeelmsmvaldpkrflhrypkEMSGGQQQRIGVIRALAADPPV 161
Cdd:cd03230   75 IGYLPEEPSLYENLTVRENL--------------------------------------KLSGGMKQRLALAQALLHDPEL 116

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 727180512 162 LLMDEPFGAVDPINRETIQNEFLDMQRQlKKTVMLVSHDIDEALKLGDRIAVFRQGKI 219
Cdd:cd03230  117 LILDEPTSGLDPESRREFWELLRELKKE-GKTILLSSHILEEAERLCDRVAILNNGRI 173

fbpC

PRK11432

ferric ABC transporter ATP-binding protein;

4-243

2.81e-60

ferric ABC transporter ATP-binding protein;

Pssm-ID: 183133 [Multi-domain] Cd Length: 351 Bit Score: 198.40 E-value: 2.81e-60

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   4 LENLTKQFmqknGTpfNAV-DNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSalDTVSLRRKI 82
Cdd:PRK11432   9 LKNITKRF----GS--NTViDNLNLTIKQGTMVTLLGPSGCGKTTVLRLVAGLEKPTEGQIFIDGEDVT--HRSIQQRDI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  83 GYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPkrFLHRYPKEMSGGQQQRIGVIRALAADPPVL 162
Cdd:PRK11432  81 CMVFQSYALFPHMSLGENVGYGLKMLGVPKEERKQRVKEALELVDLAG--FEDRYVDQISGGQQQRVALARALILKPKVL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 163 LMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEFVASFVG 242
Cdd:PRK11432 159 LFDEPLSNLDANLRRSMREKIRELQQQFNITSLYVTHDQSEAFAVSDTVIVMNKGKIMQIGSPQELYRQPASRFMASFMG 238


                 .
gi 727180512 243 Q 243
Cdd:PRK11432 239 D 239

DppF

COG1124

ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid ...

1-236

3.09e-60

ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];

Pssm-ID: 440741 [Multi-domain] Cd Length: 248 Bit Score: 194.64 E-value: 3.09e-60

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQKNGTPFnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRR 80
Cdd:COG1124    1 MLEVRNLSVSYGQGGRRVP-VLKDVSLEVAPGESFGLVGESGSGKSTLLRALAGLERPWSGEVTFDGRPVTRRRRKAFRR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQQIG--LFPNMTIEENITVVPRMLGWDKKRchARAEELMSMVALDPkRFLHRYPKEMSGGQQQRIGVIRALAAD 158
Cdd:COG1124   80 RVQMVFQDPYasLHPRHTVDRILAEPLRIHGLPDRE--ERIAELLEQVGLPP-SFLDRYPHQLSGGQRQRVAIARALILE 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727180512 159 PPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEF 236
Cdd:COG1124  157 PELLLLDEPTSALDVSVQAEILNLLKDLREERGLTYLFVSHDLAVVAHLCDRVAVMQNGRIVEELTVADLLAGPKHPY 234

FtsE

COG2884

Cell division ATPase FtsE [Cell cycle control, cell division, chromosome partitioning];

1-220

2.03e-59

Cell division ATPase FtsE [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 442130 [Multi-domain] Cd Length: 223 Bit Score: 191.80 E-value: 2.03e-59

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqKNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSAL---DTVS 77
Cdd:COG2884    1 MIRFENVSKRY--PGGRE--ALSDVSLEIEKGEFVFLTGPSGAGKSTLLKLLYGEERPTSGQVLVNGQDLSRLkrrEIPY 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  78 LRRKIGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKrfLHRYPKEMSGGQQQRIGVIRALAA 157
Cdd:COG2884   77 LRRRIGVVFQDFRLLPDRTVYENVALPLRVTGKSRKEIRRRVREVLDLVGLSDK--AKALPHELSGGEQQRVAIARALVN 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727180512 158 DPPVLLMDEPFGAVDPINRETIQNEFLDMQRqLKKTVMLVSHDIDEALKLGDRIAVFRQGKIV 220
Cdd:COG2884  155 RPELLLADEPTGNLDPETSWEIMELLEEINR-RGTTVLIATHDLELVDRMPKRVLELEDGRLV 216

DppD

COG0444

ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid ...

1-233

3.52e-59

ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];

Pssm-ID: 440213 [Multi-domain] Cd Length: 320 Bit Score: 194.50 E-value: 3.52e-59

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQKNGTpFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEP---TGGTILINGEDTSALDTVS 77
Cdd:COG0444    1 LLEVRNLKVYFPTRRGV-VKAVDGVSFDVRRGETLGLVGESGSGKSTLARAILGLLPPpgiTSGEILFDGEDLLKLSEKE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  78 LR----RKIGYVIQ--QIGLFPNMTIEENITVVPRM-LGWDKKRCHARAEELMSMVAL-DPKRFLHRYPKEMSGGQQQRI 149
Cdd:COG0444   80 LRkirgREIQMIFQdpMTSLNPVMTVGDQIAEPLRIhGGLSKAEARERAIELLERVGLpDPERRLDRYPHELSGGMRQRV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 150 GVIRALAADPPVLLMDEPFGAVDPinreTIQ----NEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASA 225
Cdd:COG0444  160 MIARALALEPKLLIADEPTTALDV----TIQaqilNLLKDLQRELGLAILFITHDLGVVAEIADRVAVMYAGRIVEEGPV 235


                 ....*...
gi 727180512 226 DELLARPA 233
Cdd:COG0444  236 EELFENPR 243

ECF_ATPase_2

TIGR04521

energy-coupling factor transporter ATPase; Members of this family are ATP-binding cassette ...

2-232

4.50e-59

energy-coupling factor transporter ATPase; Members of this family are ATP-binding cassette (ABC) proteins by homology, but belong to energy coupling factor (ECF) transport systems. The architecture in general is two ATPase subunits (or a double-length fusion protein), a T component, and a substrate capture (S) component that is highly variable, and may be interchangeable in genomes with only one T component. This model identifies many but not examples of the downstream member of the pair of ECF ATPases in Firmicutes and Mollicutes. [Transport and binding proteins, Unknown substrate]

Pssm-ID: 275314 [Multi-domain] Cd Length: 277 Bit Score: 192.67 E-value: 4.50e-59

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512    2 IKLENLTKQFMQknGTPF--NAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVS-- 77
Cdd:TIGR04521   1 IKLKNVSYIYQP--GTPFekKALDDVSLTIEDGEFVAIIGHTGSGKSTLIQHLNGLLKPTSGTVTIDGRDITAKKKKKlk 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   78 -LRRKIGYVIQ----QigLFPNmTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKrFLHRYPKEMSGGQQQRIGVI 152
Cdd:TIGR04521  79 dLRKKVGLVFQfpehQ--LFEE-TVYKDIAFGPKNLGLSEEEAEERVKEALELVGLDEE-YLERSPFELSGGQMRRVAIA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  153 RALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARP 232
Cdd:TIGR04521 155 GVLAMEPEVLILDEPTAGLDPKGRKEILDLFKRLHKEKGLTVILVTHSMEDVAEYADRVIVMHKGKIVLDGTPREVFSDV 234

metN

PRK11153

DL-methionine transporter ATP-binding subunit; Provisional

1-244

1.50e-58

DL-methionine transporter ATP-binding subunit; Provisional

Pssm-ID: 236863 [Multi-domain] Cd Length: 343 Bit Score: 193.48 E-value: 1.50e-58

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQKNGtPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSL-- 78
Cdd:PRK11153   1 MIELKNISKVFPQGGR-TIHALNNVSLHIPAGEIFGVIGASGAGKSTLIRCINLLERPTSGRVLVDGQDLTALSEKELrk 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  79 -RRKIGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIGVIRALAA 157
Cdd:PRK11153  80 aRRQIGMIFQHFNLLSSRTVFDNVALPLELAGTPKAEIKARVTELLELVGLSDKA--DRYPAQLSGGQKQRVAIARALAS 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 158 DPPVLLMDEPFGAVDPinrETIQN--EFL-DMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARP-- 232
Cdd:PRK11153 158 NPKVLLCDEATSALDP---ATTRSilELLkDINRELGLTIVLITHEMDVVKRICDRVAVIDAGRLVEQGTVSEVFSHPkh 234

                        250
                 ....*....|....
gi 727180512 233 --ANEFVASFVGQD 244
Cdd:PRK11153 235 plTREFIQSTLHLD 248

3a0107s01c2

TIGR00972

phosphate ABC transporter, ATP-binding protein; This model represents the ATP-binding protein ...

2-241

5.72e-58

phosphate ABC transporter, ATP-binding protein; This model represents the ATP-binding protein of a family of ABC transporters for inorganic phosphate. In the model species Escherichia coli, a constitutive transporter for inorganic phosphate, with low affinity, is also present. The high affinity transporter that includes this polypeptide is induced when extracellular phosphate concentrations are low. The proteins most similar to the members of this family but not included appear to be amino acid transporters. [Transport and binding proteins, Anions]

Pssm-ID: 273372 [Multi-domain] Cd Length: 247 Bit Score: 189.04 E-value: 5.72e-58

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512    2 IKLENLTKQFMQkngtpFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIE-----PTGGTILINGED--TSALD 74
Cdd:TIGR00972   2 IEIENLNLFYGE-----KEALKNINLDIPKNQVTALIGPSGCGKSTLLRSLNRMNDlvpgvRIEGKVLFDGQDiyDKKID 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   75 TVSLRRKIGYVIQQIGLFPnMTIEENITVVPRMLGW-DKKRCHARAEELMSMVAL--DPKRFLHRYPKEMSGGQQQRIGV 151
Cdd:TIGR00972  77 VVELRRRVGMVFQKPNPFP-MSIYDNIAYGPRLHGIkDKKELDEIVEESLKKAALwdEVKDRLHDSALGLSGGQQQRLCI 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  152 IRALAADPPVLLMDEPFGAVDPINRETIQneflDMQRQLKK--TVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELL 229
Cdd:TIGR00972 156 ARALAVEPEVLLLDEPTSALDPIATGKIE----ELIQELKKkyTIVIVTHNMQQAARISDRTAFFYDGELVEYGPTEQIF 231

                         250
                  ....*....|..
gi 727180512  230 ARPANEFVASFV 241
Cdd:TIGR00972 232 TNPKEKRTEDYI 243

ABC_cobalt_CbiO_domain1

cd03225

First domain of the ATP-binding cassette component of cobalt transport system; Domain I of the ...

3-218

7.65e-58

First domain of the ATP-binding cassette component of cobalt transport system; Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.

Pssm-ID: 213192 [Multi-domain] Cd Length: 211 Bit Score: 187.29 E-value: 7.65e-58

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   3 KLENLTKQFmqkNGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRKI 82
Cdd:cd03225    1 ELKNLSFSY---PDGARPALDDISLTIKKGEFVLIVGPNGSGKSTLLRLLNGLLGPTSGEVLVDGKDLTKLSLKELRRKV 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  83 GYVIQ----QigLFpNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPkrFLHRYPKEMSGGQQQRIGVIRALAAD 158
Cdd:cd03225   78 GLVFQnpddQ--FF-GPTVEEEVAFGLENLGLPEEEIEERVEEALELVGLEG--LRDRSPFTLSGGQKQRVAIAGVLAMD 152

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 159 PPVLLMDEPFGAVDPINRETIQNEFLDMQRQlKKTVMLVSHDIDEALKLGDRIAVFRQGK 218
Cdd:cd03225  153 PDILLLDEPTAGLDPAGRRELLELLKKLKAE-GKTIIIVTHDLDLLLELADRVIVLEDGK 211

TauB

COG4525

ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism];

1-221

2.43e-57

ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism];

Pssm-ID: 443596 [Multi-domain] Cd Length: 262 Bit Score: 187.76 E-value: 2.43e-57

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmQKNGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEdtsALDTVSLRR 80
Cdd:COG4525    3 MLTVRHVSVRY-PGGGQPQPALQDVSLTIESGEFVVALGASGCGKTTLLNLIAGFLAPSSGEITLDGV---PVTGPGADR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 kiGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDpkRFLHRYPKEMSGGQQQRIGVIRALAADPP 160
Cdd:COG4525   79 --GVVFQKDALLPWLNVLDNVAFGLRLRGVPKAERRARAEELLALVGLA--DFARRRIWQLSGGMRQRVGIARALAADPR 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727180512 161 VLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVF--RQGKIVQ 221
Cdd:COG4525  155 FLLMDEPFGALDALTREQMQELLLDVWQRTGKGVFLITHSVEEALFLATRLVVMspGPGRIVE 217

PRK10070

proline/glycine betaine ABC transporter ATP-binding protein ProV;

9-360

6.02e-57

proline/glycine betaine ABC transporter ATP-binding protein ProV;

Pssm-ID: 182221 [Multi-domain] Cd Length: 400 Bit Score: 191.01 E-value: 6.02e-57

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   9 KQFMQKNGTPFnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLR----RKIGY 84
Cdd:PRK10070  32 EQILEKTGLSL-GVKDASLAIEEGEIFVIMGLSGSGKSTMVRLLNRLIEPTRGQVLIDGVDIAKISDAELRevrrKKIAM 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  85 VIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDpkRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLM 164
Cdd:PRK10070 111 VFQSFALMPHMTVLDNTAFGMELAGINAEERREKALDALRQVGLE--NYAHSYPDELSGGMRQRVGLARALAINPDILLM 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 165 DEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEFVASFVgqd 244
Cdd:PRK10070 189 DEAFSALDPLIRTEMQDELVKLQAKHQRTIVFISHDLDEAMRIGDRIAIMQNGEVVQVGTPDEILNNPANDYVRTFF--- 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 245 RTLKRLLLVQAGDVAgQQETVTVRRETPLV---EAFGLMDDIDARSVTVVDADGKPLGYVKRREARGAPGVcADSLHRFR 321
Cdd:PRK10070 266 RGVDISQVFSAKDIA-RRTPNGLIRKTPGFgprSALKLLQDEDREYGYVIERGNKFVGAVSIDSLKTALTQ-QQGLDAAL 343

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 727180512 322 VTARAEENLRVVLSKLYEH---NTSWMPIVDEDGRYSGEISQ 360
Cdd:PRK10070 344 IDAPLAVDAQTPLSELLSHvgqAPCAVPVVDEDQQYVGIISK 385

ABC_subfamily_A

cd03263

ATP-binding cassette domain of the lipid transporters, subfamily A; The ABCA subfamily ...

2-228

1.31e-56

ATP-binding cassette domain of the lipid transporters, subfamily A; The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency, degenerative retinopathies, and congenital keratinization disorders. The ABCA1 protein is involved in disorders of cholesterol transport and high-density lipoprotein (HDL) biosynthesis. The ABCA4 (ABCR) protein transports vitamin A derivatives in the outer segments of photoreceptor cells, and therefore, performs a crucial step in the visual cycle. The ABCA genes are not present in yeast. However, evolutionary studies of ABCA genes indicate that they arose as transporters that subsequently duplicated and that certain sets of ABCA genes were lost in different eukaryotic lineages.

Pssm-ID: 213230 [Multi-domain] Cd Length: 220 Bit Score: 184.25 E-value: 1.31e-56

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFmqkNGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSAlDTVSLRRK 81
Cdd:cd03263    1 LQIRNLTKTY---KKGTKPAVDDLSLNVYKGEIFGLLGHNGAGKTTTLKMLTGELRPTSGTAYINGYSIRT-DRKAARQS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIGVIRALAADPPV 161
Cdd:cd03263   77 LGYCPQFDALFDELTVREHLRFYARLKGLPKSEIKEEVELLLRVLGLTDKA--NKRARTLSGGMKRKLSLAIALIGGPSV 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 727180512 162 LLMDEPFGAVDPINRETIQNEFLDMQRQlkKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADEL 228
Cdd:cd03263  155 LLLDEPTSGLDPASRRAIWDLILEVRKG--RSIILTTHSMDEAEALCDRIAIMSDGKLRCIGSPQEL 219

PRK10851

sulfate/thiosulfate ABC transporter ATP-binding protein CysA;

2-262

8.49e-56

sulfate/thiosulfate ABC transporter ATP-binding protein CysA;

Pssm-ID: 182778 [Multi-domain] Cd Length: 353 Bit Score: 186.83 E-value: 8.49e-56

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFMQKNgtpfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSaldTVSLR-R 80
Cdd:PRK10851   3 IEIANIKKSFGRTQ-----VLNDISLDIPSGQMVALLGPSGSGKTTLLRIIAGLEHQTSGHIRFHGTDVS---RLHARdR 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQQIGLFPNMTIEENI----TVVPRMLGWDKKRCHARAEELMSMVALDpkRFLHRYPKEMSGGQQQRIGVIRALA 156
Cdd:PRK10851  75 KVGFVFQHYALFRHMTVFDNIafglTVLPRRERPNAAAIKAKVTQLLEMVQLA--HLADRYPAQLSGGQKQRVALARALA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 157 ADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEF 236
Cdd:PRK10851 153 VEPQILLLDEPFGALDAQVRKELRRWLRQLHEELKFTSVFVTHDQEEAMEVADRVVVMSQGNIEQAGTPDQVWREPATRF 232

                        250       260
                 ....*....|....*....|....*.
gi 727180512 237 VASFVGQDRTLKrlllvqaGDVAGQQ 262
Cdd:PRK10851 233 VLEFMGEVNRLQ-------GTIRGGQ 251

YhaQ

COG4152

ABC-type uncharacterized transport system, ATPase component [General function prediction only]; ...

1-271

1.42e-55

ABC-type uncharacterized transport system, ATPase component [General function prediction only];

Pssm-ID: 443322 [Multi-domain] Cd Length: 298 Bit Score: 184.16 E-value: 1.42e-55

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqknGTpFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDtvslRR 80
Cdd:COG4152    1 MLELKGLTKRF----GD-KTAVDDVSFTVPKGEIFGLLGPNGAGKTTTIRIILGILAPDSGEVLWDGEPLDPED----RR 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMsmvaldpKRF-LHRYPK----EMSGGQQQRIGVIRAL 155
Cdd:COG4152   72 RIGYLPEERGLYPKMKVGEQLVYLARLKGLSKAEAKRRADEWL-------ERLgLGDRANkkveELSKGNQQKVQLIAAL 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 156 AADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQlKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLAR-PAN 234
Cdd:COG4152  145 LHDPELLILDEPFSGLDPVNVELLKDVIRELAAK-GTTVIFSSHQMELVEELCDRIVIINKGRKVLSGSVDEIRRQfGRN 223

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 727180512 235 EFVASFVGQDRTLKRLLLVQAGDVAGQQETVTVRRET 271
Cdd:COG4152  224 TLRLEADGDAGWLRALPGVTVVEEDGDGAELKLEDGA 260

GsiA

COG1123

ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain ...

1-279

1.63e-55

ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain [Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 440740 [Multi-domain] Cd Length: 514 Bit Score: 190.11 E-value: 1.63e-55

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqkNGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTG---GTILINGEDTSALDTVS 77
Cdd:COG1123    4 LLEVRDLSVRY---PGGDVPAVDGVSLTIAPGETVALVGESGSGKSTLALALMGLLPHGGrisGEVLLDGRDLLELSEAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  78 LRRKIGYVIQQIG--LFPnMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDpkRFLHRYPKEMSGGQQQRIGVIRAL 155
Cdd:COG1123   81 RGRRIGMVFQDPMtqLNP-VTVGDQIAEALENLGLSRAEARARVLELLEAVGLE--RRLDRYPHQLSGGQRQRVAIAMAL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 156 AADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPAne 235
Cdd:COG1123  158 ALDPDLLIADEPTTALDVTTQAEILDLLRELQRERGTTVLLITHDLGVVAEIADRVVVMDDGRIVEDGPPEEILAAPQ-- 235

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 727180512 236 fvasfvgqdrtlkRLLLVQAGDVAGQQETVTVRRETPLVEAFGL 279
Cdd:COG1123  236 -------------ALAAVPRLGAARGRAAPAAAAAEPLLEVRNL 266

ABC_PhnC_transporter

cd03256

ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; ...

2-228

4.48e-55

ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all kingdoms of wildlife, but only prokaryotic microorganisms are able to cleave this bond. Certain bacteria such as E. coli can use alkylphosphonates as a phosphorus source. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213223 [Multi-domain] Cd Length: 241 Bit Score: 181.23 E-value: 4.48e-55

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFmqknGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSL--- 78
Cdd:cd03256    1 IEVENLSKTY----PNGKKALKDVSLSINPGEFVALIGPSGAGKSTLLRCLNGLVEPTSGSVLIDGTDINKLKGKALrql 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  79 RRKIGYVIQQIGLFPNMTIEENI--------TVVPRMLGWDKKRCHARAEELMSMVALDPKrfLHRYPKEMSGGQQQRIG 150
Cdd:cd03256   77 RRQIGMIFQQFNLIERLSVLENVlsgrlgrrSTWRSLFGLFPKEEKQRALAALERVGLLDK--AYQRADQLSGGQQQRVA 154

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727180512 151 VIRALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADEL 228
Cdd:cd03256  155 IARALMQQPKLILADEPVASLDPASSRQVMDLLKRINREEGITVIVSLHQVDLAREYADRIVGLKDGRIVFDGPPAEL 232

FetA

COG4619

ABC-type iron transporter FetAB, ATPase component [Inorganic ion transport and metabolism];

2-219

2.37e-54

ABC-type iron transporter FetAB, ATPase component [Inorganic ion transport and metabolism];

Pssm-ID: 443661 [Multi-domain] Cd Length: 209 Bit Score: 178.09 E-value: 2.37e-54

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFMQKNGtpfnaVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRK 81
Cdd:COG4619    1 LELEGLSFRVGGKPI-----LSPVSLTLEAGECVAITGPSGSGKSTLLRALADLDPPTSGEIYLDGKPLSAMPPPEWRRQ 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPNmTIEENITVVPRMLgwDKKRCHARAEELMSMVALDPKrFLHRYPKEMSGGQQQRIGVIRALAADPPV 161
Cdd:COG4619   76 VAYVPQEPALWGG-TVRDNLPFPFQLR--ERKFDRERALELLERLGLPPD-ILDKPVERLSGGERQRLALIRALLLQPDV 151

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 727180512 162 LLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKI 219
Cdd:COG4619  152 LLLDEPTSALDPENTRRVEELLREYLAEEGRAVLWVSHDPEQIERVADRVLTLEAGRL 209

AppF

COG4608

ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; ...

2-233

2.52e-54

ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism];

Pssm-ID: 443658 [Multi-domain] Cd Length: 329 Bit Score: 181.85 E-value: 2.52e-54

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQF------MQKNGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDT 75
Cdd:COG4608    8 LEVRDLKKHFpvrgglFGRTVGVVKAVDGVSFDIRRGETLGLVGESGCGKSTLGRLLLRLEEPTSGEILFDGQDITGLSG 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  76 ---VSLRRKIGYVIQ--QIGLFPNMTIEENITVVPRMLG-WDKKRCHARAEELMSMVALDPkRFLHRYPKEMSGGQQQRI 149
Cdd:COG4608   88 relRPLRRRMQMVFQdpYASLNPRMTVGDIIAEPLRIHGlASKAERRERVAELLELVGLRP-EHADRYPHEFSGGQRQRI 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 150 GVIRALAADPPVLLMDEPFGAVDpinrETIQ----NEFLDMQRQLKKTVMLVSHDidealkLG------DRIAVFRQGKI 219
Cdd:COG4608  167 GIARALALNPKLIVCDEPVSALD----VSIQaqvlNLLEDLQDELGLTYLFISHD------LSvvrhisDRVAVMYLGKI 236

                        250
                 ....*....|....
gi 727180512 220 VQNASADELLARPA 233
Cdd:COG4608  237 VEIAPRDELYARPL 250

potG

PRK11607

putrescine ABC transporter ATP-binding subunit PotG;

1-242

3.69e-54

putrescine ABC transporter ATP-binding subunit PotG;

Pssm-ID: 183226 [Multi-domain] Cd Length: 377 Bit Score: 183.11 E-value: 3.69e-54

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqkNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSalDTVSLRR 80
Cdd:PRK11607  19 LLEIRNLTKSF---DGQH--AVDDVSLTIYKGEIFALLGASGCGKSTLLRMLAGFEQPTAGQIMLDGVDLS--HVPPYQR 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALdpKRFLHRYPKEMSGGQQQRIGVIRALAADPP 160
Cdd:PRK11607  92 PINMMFQSYALFPHMTVEQNIAFGLKQDKLPKAEIASRVNEMLGLVHM--QEFAKRKPHQLSGGQRQRVALARSLAKRPK 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 161 VLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEFVASF 240
Cdd:PRK11607 170 LLLLDEPMGALDKKLRDRMQLEVVDILERVGVTCVMVTHDQEEAMTMAGRIAIMNRGKFVQIGEPEEIYEHPTTRYSAEF 249


                 ..
gi 727180512 241 VG 242
Cdd:PRK11607 250 IG 251

PstB

COG1117

ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; ...

19-235

1.34e-53

ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism];

Pssm-ID: 440734 [Multi-domain] Cd Length: 258 Bit Score: 177.92 E-value: 1.34e-53

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  19 FNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIE--P---TGGTILINGEDTSA--LDTVSLRRKIGYVIQQIGL 91
Cdd:COG1117   24 KQALKDINLDIPENKVTALIGPSGCGKSTLLRCLNRMNDliPgarVEGEILLDGEDIYDpdVDVVELRRRVGMVFQKPNP 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  92 FPnMTIEENITVVPRMLGW-DKKRCHARAEELMSMVAL--DPKRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPF 168
Cdd:COG1117  104 FP-KSIYDNVAYGLRLHGIkSKSELDEIVEESLRKAALwdEVKDRLKKSALGLSGGQQQRLCIARALAVEPEVLLMDEPT 182

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 727180512 169 GAVDPINRETIQneflDMQRQLKK--TVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANE 235
Cdd:COG1117  183 SALDPISTAKIE----ELILELKKdyTIVIVTHNMQQAARVSDYTAFFYLGELVEFGPTEQIFTNPKDK 247

glnQ

PRK09493

glutamine ABC transporter ATP-binding protein GlnQ;

1-240

6.86e-53

glutamine ABC transporter ATP-binding protein GlnQ;

Pssm-ID: 181906 [Multi-domain] Cd Length: 240 Bit Score: 175.67 E-value: 6.86e-53

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQKNgtpfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDT--SALDTVSL 78
Cdd:PRK09493   1 MIEFKNVSKHFGPTQ-----VLHNIDLNIDQGEVVVIIGPSGSGKSTLLRCINKLEEITSGDLIVDGLKVndPKVDERLI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  79 RRKIGYVIQQIGLFPNMTIEENITVVP-RMLGWDKKRCHARAEELMSMVALDPKrfLHRYPKEMSGGQQQRIGVIRALAA 157
Cdd:PRK09493  76 RQEAGMVFQQFYLFPHLTALENVMFGPlRVRGASKEEAEKQARELLAKVGLAER--AHHYPSELSGGQQQRVAIARALAV 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 158 DPPVLLMDEPFGAVDPinreTIQNEFLDMQRQLKK---TVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPAN 234
Cdd:PRK09493 154 KPKLMLFDEPTSALDP----ELRHEVLKVMQDLAEegmTMVIVTHEIGFAEKVASRLIFIDKGRIAEDGDPQVLIKNPPS 229


                 ....*.
gi 727180512 235 EFVASF 240
Cdd:PRK09493 230 QRLQEF 235

ABC_ModC_molybdenum_transporter

cd03297

ATP-binding cassette domain of the molybdenum transport system; ModC is an ABC-type ...

24-221

9.07e-53

ATP-binding cassette domain of the molybdenum transport system; ModC is an ABC-type transporter and the ATPase component of a molybdate transport system that also includes the periplasmic binding protein ModA and the membrane protein ModB. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213264 [Multi-domain] Cd Length: 214 Bit Score: 174.41 E-value: 9.07e-53

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  24 NINLDVPEgEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGE---DTS-ALDTVSLRRKIGYVIQQIGLFPNMTIEE 99
Cdd:cd03297   16 KIDFDLNE-EVTGIFGASGAGKSTLLRCIAGLEKPDGGTIVLNGTvlfDSRkKINLPPQQRKIGLVFQQYALFPHLNVRE 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 100 NITVVPRMLGWDKKRchARAEELMSMVALDPkrFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRETI 179
Cdd:cd03297   95 NLAFGLKRKRNREDR--ISVDELLDLLGLDH--LLNRYPAQLSGGEKQRVALARALAAQPELLLLDEPFSALDRALRLQL 170

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 727180512 180 QNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQ 221
Cdd:cd03297  171 LPELKQIKKNLNIPVIFVTHDLSEAEYLADRIVVMEDGRLQY 212

FepC

COG1120

ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component [Inorganic ion ...

1-229

1.37e-52

ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component [Inorganic ion transport and metabolism, Coenzyme transport and metabolism];

Pssm-ID: 440737 [Multi-domain] Cd Length: 254 Bit Score: 175.23 E-value: 1.37e-52

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqkNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRR 80
Cdd:COG1120    1 MLEAENLSVGY---GGRP--VLDDVSLSLPPGEVTALLGPNGSGKSTLLRALAGLLKPSSGEVLLDGRDLASLSRRELAR 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQQIGLFPNMTIEEnitVV-----P--RMLGWDKKRCHARAEELMSMVALDPkrFLHRYPKEMSGGQQQRIGVIR 153
Cdd:COG1120   76 RIAYVPQEPPAPFGLTVRE---LValgryPhlGLFGRPSAEDREAVEEALERTGLEH--LADRPVDELSGGERQRVLIAR 150

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727180512 154 ALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELL 229
Cdd:COG1120  151 ALAQEPPLLLLDEPTSHLDLAHQLEVLELLRRLARERGRTVVMVLHDLNLAARYADRLVLLKDGRIVAQGPPEEVL 226

ABC_DrrA

cd03265

Daunorubicin/doxorubicin resistance ATP-binding protein; DrrA is the ATP-binding protein ...

2-228

1.80e-52

Daunorubicin/doxorubicin resistance ATP-binding protein; DrrA is the ATP-binding protein component of a bacterial exporter complex that confers resistance to the antibiotics daunorubicin and doxorubicin. In addition to DrrA, the complex includes an integral membrane protein called DrrB. DrrA belongs to the ABC family of transporters and shares sequence and functional similarities with a protein found in cancer cells called P-glycoprotein. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region in addition to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213232 [Multi-domain] Cd Length: 220 Bit Score: 173.71 E-value: 1.80e-52

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFMQkngtpFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSAlDTVSLRRK 81
Cdd:cd03265    1 IEVENLVKKYGD-----FEAVRGVSFRVRRGEIFGLLGPNGAGKTTTIKMLTTLLKPTSGRATVAGHDVVR-EPREVRRR 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIGVIRALAADPPV 161
Cdd:cd03265   75 IGIVFQDLSVDDELTGWENLYIHARLYGVPGAERRERIDELLDFVGLLEAA--DRLVKTYSGGMRRRLEIARSLVHRPEV 152

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 727180512 162 LLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADEL 228
Cdd:cd03265  153 LFLDEPTIGLDPQTRAHVWEYIEKLKEEFGMTILLTTHYMEEAEQLCDRVAIIDHGRIIAEGTPEEL 219

ThiQ

COG3840

ABC-type thiamine transport system, ATPase component ThiQ [Coenzyme transport and metabolism];

1-243

2.42e-52

ABC-type thiamine transport system, ATPase component ThiQ [Coenzyme transport and metabolism];

Pssm-ID: 443051 [Multi-domain] Cd Length: 232 Bit Score: 173.79 E-value: 2.42e-52

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqkNGTPFNAvdniNLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDtsALDTVSLRR 80
Cdd:COG3840    1 MLRLDDLTYRY---GDFPLRF----DLTIAAGERVAILGPSGAGKSTLLNLIAGFLPPDSGRILWNGQD--LTALPPAER 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQQIGLFPNMTIEENITvvprmLGWDKKR-----CHARAEELMSMVALDPkrFLHRYPKEMSGGQQQRIGVIRAL 155
Cdd:COG3840   72 PVSMLFQENNLFPHLTVAQNIG-----LGLRPGLkltaeQRAQVEQALERVGLAG--LLDRLPGQLSGGQRQRVALARCL 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 156 AADPPVLLMDEPFGAVDPINREtiqnEFLDMQRQLKK----TVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLAR 231
Cdd:COG3840  145 VRKRPILLLDEPFSALDPALRQ----EMLDLVDELCRerglTVLMVTHDPEDAARIADRVLLVADGRIAADGPTAALLDG 220

                        250
                 ....*....|..
gi 727180512 232 PANEFVASFVGQ 243
Cdd:COG3840  221 EPPPALAAYLGI 232

ABC_tran

pfam00005

ABC transporter; ABC transporters for a large family of proteins responsible for translocation ...

22-168

3.12e-52

Pssm-ID: 394964 [Multi-domain] Cd Length: 150 Bit Score: 170.52 E-value: 3.12e-52

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   22 VDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRKIGYVIQQIGLFPNMTIEENI 101
Cdd:pfam00005   1 LKNVSLTLNPGEILALVGPNGAGKSTLLKLIAGLLSPTEGTILLDGQDLTDDERKSLRKEIGYVFQDPQLFPRLTVRENL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 727180512  102 TVVPRMLGWDKKRCHARAEELMSMVAL--DPKRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPF 168
Cdd:pfam00005  81 RLGLLLKGLSKREKDARAEEALEKLGLgdLADRPVGERPGTLSGGQRQRVAIARALLTKPKLLLLDEPT 149

SunT

COG2274

ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase ...

2-231

6.62e-51

ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms];

Pssm-ID: 441875 [Multi-domain] Cd Length: 711 Bit Score: 181.19 E-value: 6.62e-51

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFmqkNGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRK 81
Cdd:COG2274  474 IELENVSFRY---PGDSPPVLDNISLTIKPGERVAIVGRSGSGKSTLLKLLLGLYEPTSGRILIDGIDLRQIDPASLRRQ 550

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFpNMTIEENITVvprmlgWDKKRCHARAEELMSMVALDpkRFLHRYPK-------EM----SGGQQQRIG 150
Cdd:COG2274  551 IGVVLQDVFLF-SGTIRENITL------GDPDATDEEIIEAARLAGLH--DFIEALPMgydtvvgEGgsnlSGGQRQRLA 621

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 151 VIRALAADPPVLLMDEPFGAVDPINRETIQnEFLDmQRQLKKTVMLVSHDiDEALKLGDRIAVFRQGKIVQNASADELLA 230
Cdd:COG2274  622 IARALLRNPRILILDEATSALDAETEAIIL-ENLR-RLLKGRTVIIIAHR-LSTIRLADRIIVLDKGRIVEDGTHEELLA 698


                 .
gi 727180512 231 R 231
Cdd:COG2274  699 R 699

ABCC_MRP_Like

cd03228

ATP-binding cassette domain of multidrug resistance protein-like transporters; The MRP ...

2-218

1.11e-50

ATP-binding cassette domain of multidrug resistance protein-like transporters; The MRP (Multidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a diverse functional spectrum that includes ion transport, cell surface receptor, and toxin secretion activities. The MRP-like family, similar to all ABC proteins, have a common four-domain core structure constituted by two membrane-spanning domains, each composed of six transmembrane (TM) helices, and two nucleotide-binding domains (NBD). ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213195 [Multi-domain] Cd Length: 171 Bit Score: 167.56 E-value: 1.11e-50

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFmqkNGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRK 81
Cdd:cd03228    1 IEFKNVSFSY---PGRPKPVLKDVSLTIKPGEKVAIVGPSGSGKSTLLKLLLRLYDPTSGEILIDGVDLRDLDLESLRKN 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFpNMTIEENItvvprmlgwdkkrcharaeelmsmvaldpkrflhrypkeMSGGQQQRIGVIRALAADPPV 161
Cdd:cd03228   78 IAYVPQDPFLF-SGTIRENI---------------------------------------LSGGQRQRIAIARALLRDPPI 117

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 727180512 162 LLMDEPFGAVDPINRETIQNEFLDMQRqlKKTVMLVSHDIdEALKLGDRIAVFRQGK 218
Cdd:cd03228  118 LILDEATSALDPETEALILEALRALAK--GKTVIVIAHRL-STIRDADRIIVLDDGR 171

ZnuC

COG1121

ABC-type Mn2+/Zn2+ transport system, ATPase component [Inorganic ion transport and metabolism]; ...

1-228

1.43e-50

ABC-type Mn2+/Zn2+ transport system, ATPase component [Inorganic ion transport and metabolism];

Pssm-ID: 440738 [Multi-domain] Cd Length: 245 Bit Score: 169.50 E-value: 1.43e-50

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqkNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALdtvslRR 80
Cdd:COG1121    6 AIELENLTVSY---GGRP--VLEDVSLTIPPGEFVAIVGPNGAGKSTLLKAILGLLPPTSGTVRLFGKPPRRA-----RR 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQQIGL---FPnMTIEEnitVVprMLGWD---------KKRCHARAEELMSMVALDPkrFLHRYPKEMSGGQQQR 148
Cdd:COG1121   76 RIGYVPQRAEVdwdFP-ITVRD---VV--LMGRYgrrglfrrpSRADREAVDEALERVGLED--LADRPIGELSGGQQQR 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 149 IGVIRALAADPPVLLMDEPFGAVDPINRETIQnEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADEL 228
Cdd:COG1121  148 VLLARALAQDPDLLLLDEPFAGVDAATEEALY-ELLRELRREGKTILVVTHDLGAVREYFDRVLLLNRGLVAHGPPEEVL 226

ABC_phnC

TIGR02315

phosphonate ABC transporter, ATP-binding protein; Phosphonates are a class of ...

1-228

1.75e-50

phosphonate ABC transporter, ATP-binding protein; Phosphonates are a class of phosphorus-containing organic compound with a stable direct C-P bond rather than a C-O-P linkage. A number of bacterial species have operons, typically about 14 genes in size, with genes for ATP-dependent transport of phosphonates, degradation, and regulation of the expression of the system. Members of this protein family are the ATP-binding cassette component of tripartite ABC transporters of phosphonates. [Transport and binding proteins, Anions]

Pssm-ID: 131368 [Multi-domain] Cd Length: 243 Bit Score: 169.40 E-value: 1.75e-50

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512    1 MIKLENLTKQFmqKNGTpfNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSAL---DTVS 77
Cdd:TIGR02315   1 MLEVENLSKVY--PNGK--QALKNINLNINPGEFVAIIGPSGAGKSTLLRCINRLVEPSSGSILLEGTDITKLrgkKLRK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   78 LRRKIGYVIQQIGLFPNMTIEENI--------TVVPRMLGWDKKRCHARAEELMSMVALDpkRFLHRYPKEMSGGQQQRI 149
Cdd:TIGR02315  77 LRRRIGMIFQHYNLIERLTVLENVlhgrlgykPTWRSLLGRFSEEDKERALSALERVGLA--DKAYQRADQLSGGQQQRV 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 727180512  150 GVIRALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADEL 228
Cdd:TIGR02315 155 AIARALAQQPDLILADEPIASLDPKTSKQVMDYLKRINKEDGITVIINLHQVDLAKKYADRIVGLKAGEIVFDGAPSEL 233

ArtP

COG4161

ABC-type arginine transport system, ATPase component [Amino acid transport and metabolism];

2-240

3.77e-50

ABC-type arginine transport system, ATPase component [Amino acid transport and metabolism];

Pssm-ID: 443326 [Multi-domain] Cd Length: 242 Bit Score: 168.65 E-value: 3.77e-50

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFMQkngtpFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGE------DTSALDT 75
Cdd:COG4161    3 IQLKNINCFYGS-----HQALFDINLECPSGETLVLLGPSGAGKSSLLRVLNLLETPDSGQLNIAGHqfdfsqKPSEKAI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  76 VSLRRKIGYVIQQIGLFPNMTIEENITVVP-RMLGWDKKRCHARAEELMSMVALDPkrFLHRYPKEMSGGQQQRIGVIRA 154
Cdd:COG4161   78 RLLRQKVGMVFQQYNLWPHLTVMENLIEAPcKVLGLSKEQAREKAMKLLARLRLTD--KADRFPLHLSGGQQQRVAIARA 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 155 LAADPPVLLMDEPFGAVDPinreTIQNEFLDMQRQLKK---TVMLVSHDIDEALKLGDRIAVFRQGKIVQNASAdELLAR 231
Cdd:COG4161  156 LMMEPQVLLFDEPTAALDP----EITAQVVEIIRELSQtgiTQVIVTHEVEFARKVASQVVYMEKGRIIEQGDA-SHFTQ 230


                 ....*....
gi 727180512 232 PANEFVASF 240
Cdd:COG4161  231 PQTEAFAHY 239

cbiO

PRK13637

energy-coupling factor transporter ATPase;

2-220

1.72e-49

energy-coupling factor transporter ATPase;

Pssm-ID: 237455 [Multi-domain] Cd Length: 287 Bit Score: 168.30 E-value: 1.72e-49

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFMQknGTPFN--AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTS--ALDTVS 77
Cdd:PRK13637   3 IKIENLTHIYME--GTPFEkkALDNVNIEIEDGEFVGLIGHTGSGKSTLIQHLNGLLKPTSGKIIIDGVDITdkKVKLSD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  78 LRRKIGYVIQ--QIGLFPNmTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKRFLHRYPKEMSGGQQQRIGVIRAL 155
Cdd:PRK13637  81 IRKKVGLVFQypEYQLFEE-TIEKDIAFGPINLGLSEEEIENRVKRAMNIVGLDYEDYKDKSPFELSGGQKRRVAIAGVV 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727180512 156 AADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIV 220
Cdd:PRK13637 160 AMEPKILILDEPTAGLDPKGRDEILNKIKELHKEYNMTIILVSHSMEDVAKLADRIIVMNKGKCE 224

ABC_putative_ATPase

cd03269

ATP-binding cassette domain of an uncharacterized transporter; This subgroup is related to the ...

2-220

2.27e-49

ATP-binding cassette domain of an uncharacterized transporter; This subgroup is related to the subfamily A transporters involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two integral membranes. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region in addition to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213236 [Multi-domain] Cd Length: 210 Bit Score: 165.53 E-value: 2.27e-49

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFMQKNgtpfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDtvslRRK 81
Cdd:cd03269    1 LEVENVTKRFGRVT-----ALDDISFSVEKGEIFGLLGPNGAGKTTTIRMILGIILPDSGEVLFDGKPLDIAA----RNR 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIGVIRALAADPPV 161
Cdd:cd03269   72 IGYLPEERGLYPKMKVIDQLVYLAQLKGLKKEEARRRIDEWLERLELSEYA--NKRVEELSKGNQQKVQFIAAVIHDPEL 149

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 727180512 162 LLMDEPFGAVDPINRETIQNEFLDMQRQlKKTVMLVSHDIDEALKLGDRIAVFRQGKIV 220
Cdd:cd03269  150 LILDEPFSGLDPVNVELLKDVIRELARA-GKTVILSTHQMELVEELCDRVLLLNKGRAV 207

ABC_Mj1267_LivG_branched

cd03219

ATP-binding cassette component of branched chain amino acids transport system; The Mj1267/LivG ...

2-233

9.35e-49

ATP-binding cassette component of branched chain amino acids transport system; The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E. coli branched-chain amino acid transporter. MJ1267 contains an insertion from residues 114 to 123 characteristic of LivG (Leucine-Isoleucine-Valine) homologs. The branched-chain amino acid transporter from E. coli comprises a heterodimer of ABCs (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ).

Pssm-ID: 213186 [Multi-domain] Cd Length: 236 Bit Score: 164.53 E-value: 9.35e-49

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFmqkngTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSL-RR 80
Cdd:cd03219    1 LEVRGLTKRF-----GGLVALDDVSFSVRPGEIHGLIGPNGAGKTTLFNLISGFLRPTSGSVLFDGEDITGLPPHEIaRL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQQIGLFPNMTIEENITVV------PRMLGW----DKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIG 150
Cdd:cd03219   76 GIGRTFQIPRLFPELTVLENVMVAaqartgSGLLLArarrEEREARERAEELLERVGLADLA--DRPAGELSYGQQRRLE 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 151 VIRALAADPPVLLMDEPFGAVDPINRETIQNEFLDMqRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLA 230
Cdd:cd03219  154 IARALATDPKLLLLDEPAAGLNPEETEELAELIREL-RERGITVLLVEHDMDVVMSLADRVTVLDQGRVIAEGTPDEVRN 232


                 ...
gi 727180512 231 RPA 233
Cdd:cd03219  233 NPR 235

artP

PRK11124

arginine transporter ATP-binding subunit; Provisional

21-226

2.21e-48

arginine transporter ATP-binding subunit; Provisional

Pssm-ID: 182980 [Multi-domain] Cd Length: 242 Bit Score: 164.03 E-value: 2.21e-48

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  21 AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILING------EDTSALDTVSLRRKIGYVIQQIGLFPN 94
Cdd:PRK11124  17 ALFDITLDCPQGETLVLLGPSGAGKSSLLRVLNLLEMPRSGTLNIAGnhfdfsKTPSDKAIRELRRNVGMVFQQYNLWPH 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  95 MTIEENITVVP-RMLGWDKKRCHARAEELMSMVALDPkrFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDP 173
Cdd:PRK11124  97 LTVQQNLIEAPcRVLGLSKDQALARAEKLLERLRLKP--YADRFPLHLSGGQQQRVAIARALMMEPQVLLFDEPTAALDP 174

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 727180512 174 inreTIQNEFLDMQRQLKKT---VMLVSHDIDEALKLGDRIAVFRQGKIVQNASAD 226
Cdd:PRK11124 175 ----EITAQIVSIIRELAETgitQVIVTHEVEVARKTASRVVYMENGHIVEQGDAS 226

LivG

COG0411

ABC-type branched-chain amino acid transport system, ATPase component LivG [Amino acid ...

1-220

7.16e-48

ABC-type branched-chain amino acid transport system, ATPase component LivG [Amino acid transport and metabolism];

Pssm-ID: 440180 [Multi-domain] Cd Length: 257 Bit Score: 162.90 E-value: 7.16e-48

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqknGTpFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSL-R 79
Cdd:COG0411    4 LLEVRGLTKRF----GG-LVAVDDVSLEVERGEIVGLIGPNGAGKTTLFNLITGFYRPTSGRILFDGRDITGLPPHRIaR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  80 RKIGYVIQQIGLFPNMTIEENITV----------VPRMLGWDK-----KRCHARAEELMSMVALDPKRflHRYPKEMSGG 144
Cdd:COG0411   79 LGIARTFQNPRLFPELTVLENVLVaaharlgrglLAALLRLPRarreeREARERAEELLERVGLADRA--DEPAGNLSYG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 145 QQQRIGVIRALAADPPVLLMDEPFGAVDPinRETiqNEFLDMQRQLKK----TVMLVSHDIDEALKLGDRIAVFRQGKIV 220
Cdd:COG0411  157 QQRRLEIARALATEPKLLLLDEPAAGLNP--EET--EELAELIRRLRDergiTILLIEHDMDLVMGLADRIVVLDFGRVI 232

ugpC

PRK11650

sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC;

1-242

1.15e-47

sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC;

Pssm-ID: 236947 [Multi-domain] Cd Length: 356 Bit Score: 165.40 E-value: 1.15e-47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqKNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSlrR 80
Cdd:PRK11650   3 GLKLQAVRKSY--DGKTQ--VIKGIDLDVADGEFIVLVGPSGCGKSTLLRMVAGLERITSGEIWIGGRVVNELEPAD--R 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPkrFLHRYPKEMSGGQQQRIGVIRALAADPP 160
Cdd:PRK11650  77 DIAMVFQNYALYPHMSVRENMAYGLKIRGMPKAEIEERVAEAARILELEP--LLDRKPRELSGGQRQRVAMGRAIVREPA 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 161 VLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEFVASF 240
Cdd:PRK11650 155 VFLFDEPLSNLDAKLRVQMRLEIQRLHRRLKTTSLYVTHDQVEAMTLADRVVVMNGGVAEQIGTPVEVYEKPASTFVASF 234


                 ..
gi 727180512 241 VG 242
Cdd:PRK11650 235 IG 236

PRK11264

putative amino-acid ABC transporter ATP-binding protein YecC; Provisional

1-243

1.38e-47

putative amino-acid ABC transporter ATP-binding protein YecC; Provisional

Pssm-ID: 183063 [Multi-domain] Cd Length: 250 Bit Score: 162.23 E-value: 1.38e-47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqKNGTPFNAVDninLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVS--- 77
Cdd:PRK11264   3 AIEVKNLVKKF--HGQTVLHGID---LEVKPGEVVAIIGPSGSGKTTLLRCINLLEQPEAGTIRVGDITIDTARSLSqqk 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  78 -----LRRKIGYVIQQIGLFPNMTIEENITVVPRML-GWDKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIGV 151
Cdd:PRK11264  78 glirqLRQHVGFVFQNFNLFPHRTVLENIIEGPVIVkGEPKEEATARARELLAKVGLAGKE--TSYPRRLSGGQQQRVAI 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 152 IRALAADPPVLLMDEPFGAVDPinreTIQNEFLDMQRQL---KKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADEL 228
Cdd:PRK11264 156 ARALAMRPEVILFDEPTSALDP----ELVGEVLNTIRQLaqeKRTMVIVTHEMSFARDVADRAIFMDQGRIVEQGPAKAL 231

                        250
                 ....*....|....*....
gi 727180512 229 LARPANE----FVASFVGQ 243
Cdd:PRK11264 232 FADPQQPrtrqFLEKFLLQ 250

ABC_BcrA_bacitracin_resist

cd03268

ATP-binding cassette domain of the bacitracin-resistance transporter; The BcrA subfamily ...

2-220

4.94e-47

ATP-binding cassette domain of the bacitracin-resistance transporter; The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.

Pssm-ID: 213235 [Multi-domain] Cd Length: 208 Bit Score: 159.30 E-value: 4.94e-47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFMQKNgtpfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSalDTVSLRRK 81
Cdd:cd03268    1 LKTNDLTKTYGKKR-----VLDDISLHVKKGEIYGFLGPNGAGKTTTMKIILGLIKPDSGEITFDGKSYQ--KNIEALRR 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCharaEELMSMVALDPKRflHRYPKEMSGGQQQRIGVIRALAADPPV 161
Cdd:cd03268   74 IGALIEAPGFYPNLTARENLRLLARLLGIRKKRI----DEVLDVVGLKDSA--KKKVKGFSLGMKQRLGIALALLGNPDL 147

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 727180512 162 LLMDEPFGAVDPINRETIQNEFLDMQRQlKKTVMLVSHDIDEALKLGDRIAVFRQGKIV 220
Cdd:cd03268  148 LILDEPTNGLDPDGIKELRELILSLRDQ-GITVLISSHLLSEIQKVADRIGIINKGKLI 205

CydC

COG4987

ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease ...

2-233

5.84e-47

ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 444011 [Multi-domain] Cd Length: 569 Bit Score: 168.02 E-value: 5.84e-47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFmqkNGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRK 81
Cdd:COG4987  334 LELEDVSFRY---PGAGRPVLDGLSLTLPPGERVAIVGPSGSGKSTLLALLLRFLDPQSGSITLGGVDLRDLDEDDLRRR 410

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFpNMTIEENITVVprmlgwdkkRCHARAEELMSM---VALDPkrFLHRYPK-----------EMSGGQQQ 147
Cdd:COG4987  411 IAVVPQRPHLF-DTTLRENLRLA---------RPDATDEELWAAlerVGLGD--WLAALPDgldtwlgeggrRLSGGERR 478

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 148 RIGVIRALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQlkKTVMLVSHDIdEALKLGDRIAVFRQGKIVQNASADE 227
Cdd:COG4987  479 RLALARALLRDAPILLLDEPTEGLDAATEQALLADLLEALAG--RTVLLITHRL-AGLERMDRILVLEDGRIVEQGTHEE 555


                 ....*.
gi 727180512 228 LLARPA 233
Cdd:COG4987  556 LLAQNG 561

ABC_ATPase

cd00267

ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ...

3-218

5.85e-47

ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213179 [Multi-domain] Cd Length: 157 Bit Score: 157.41 E-value: 5.85e-47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   3 KLENLTKQFMQKNgtpfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRKI 82
Cdd:cd00267    1 EIENLSFRYGGRT-----ALDNVSLTLKAGEIVALVGPNGSGKSTLLRAIAGLLKPTSGEILIDGKDIAKLPLEELRRRI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  83 GYVIQqiglfpnmtieenitvvprmlgwdkkrcharaeelmsmvaldpkrflhrypkeMSGGQQQRIGVIRALAADPPVL 162
Cdd:cd00267   76 GYVPQ-----------------------------------------------------LSGGQRQRVALARALLLNPDLL 102

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 727180512 163 LMDEPFGAVDPINRETIQNEFLDMQRQlKKTVMLVSHDIDEALKLGDRIAVFRQGK 218
Cdd:cd00267  103 LLDEPTSGLDPASRERLLELLRELAEE-GRTVIIVTHDPELAELAADRVIVLKDGK 157

FtsE

TIGR02673

cell division ATP-binding protein FtsE; This model describes FtsE, a member of the ABC ...

1-218

1.08e-46

cell division ATP-binding protein FtsE; This model describes FtsE, a member of the ABC transporter ATP-binding protein family. This protein, and its permease partner FtsX, localize to the division site. In a number of species, the ftsEX gene pair is located next to FtsY, the signal recognition particle-docking protein. [Cellular processes, Cell division]

Pssm-ID: 131721 [Multi-domain] Cd Length: 214 Bit Score: 158.57 E-value: 1.08e-46

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512    1 MIKLENLTKQFmqknGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSAL---DTVS 77
Cdd:TIGR02673   1 MIEFHNVSKAY----PGGVAALHDVSLHIRKGEFLFLTGPSGAGKTTLLKLLYGALTPSRGQVRIAGEDVNRLrgrQLPL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   78 LRRKIGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKrfLHRYPKEMSGGQQQRIGVIRALAA 157
Cdd:TIGR02673  77 LRRRIGVVFQDFRLLPDRTVYENVALPLEVRGKKEREIQRRVGAALRQVGLEHK--ADAFPEQLSGGEQQRVAIARAIVN 154

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 727180512  158 DPPVLLMDEPFGAVDPINRETIqnefLDMQRQLKK---TVMLVSHDIDEALKLGDRIAVFRQGK 218
Cdd:TIGR02673 155 SPPLLLADEPTGNLDPDLSERI----LDLLKRLNKrgtTVIVATHDLSLVDRVAHRVIILDDGR 214

ABC_NatA_sodium_exporter

cd03266

ATP-binding cassette domain of the Na+ transporter; NatA is the ATPase component of a ...

1-220

1.99e-46

ATP-binding cassette domain of the Na+ transporter; NatA is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled proton or K+ uptake. NatB possess six putative membrane spanning regions at its C-terminus. In B. subtilis, NatAB is inducible by agents such as ethanol and protonophores, which lower the proton-motive force across the membrane. The closest sequence similarity to NatA is exhibited by DrrA of the two-component daunorubicin- and doxorubicin-efflux system. Hence, the functional NatAB is presumably assembled with two copies of a single ATP-binding protein and a single integral membrane protein.

Pssm-ID: 213233 [Multi-domain] Cd Length: 218 Bit Score: 157.91 E-value: 1.99e-46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmQKNGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSAlDTVSLRR 80
Cdd:cd03266    1 MITADALTKRF-RDVKKTVQAVDGVSFTVKPGEVTGLLGPNGAGKTTTLRMLAGLLEPDAGFATVDGFDVVK-EPAEARR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMvaLDPKRFLHRYPKEMSGGQQQRIGVIRALAADPP 160
Cdd:cd03266   79 RLGFVSDSTGLYDRLTARENLEYFAGLYGLKGDELTARLEELADR--LGMEELLDRRVGGFSTGMRQKVAIARALVHDPP 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 161 VLLMDEPFGAVDPINRETIQnEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIV 220
Cdd:cd03266  157 VLLLDEPTTGLDVMATRALR-EFIRQLRALGKCILFSTHIMQEVERLCDRVVVLHRGRVV 215

ABC_TM1139_LivF_branched

cd03224

ATP-binding cassette domain of branched-chain amino acid transporter; LivF (TM1139) is part of ...

21-230

4.00e-46

ATP-binding cassette domain of branched-chain amino acid transporter; LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ). ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules.

Pssm-ID: 213191 [Multi-domain] Cd Length: 222 Bit Score: 157.21 E-value: 4.00e-46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  21 AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVS-LRRKIGYVIQQIGLFPNMTIEE 99
Cdd:cd03224   15 ILFGVSLTVPEGEIVALLGRNGAGKTTLLKTIMGLLPPRSGSIRFDGRDITGLPPHErARAGIGYVPEGRRIFPELTVEE 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 100 NItvvprMLGWDKKRCHARAEELMSMVALDP--KRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPInre 177
Cdd:cd03224   95 NL-----LLGAYARRRAKRKARLERVYELFPrlKERRKQLAGTLSGGEQQMLAIARALMSRPKLLLLDEPSEGLAPK--- 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 727180512 178 tIQNEFLDMQRQLKK---TVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLA 230
Cdd:cd03224  167 -IVEEIFEAIRELRDegvTILLVEQNARFALEIADRAYVLERGRVVLEGTAAELLA 221

MdlB

COG1132

ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms];

2-231

1.53e-45

ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms];

Pssm-ID: 440747 [Multi-domain] Cd Length: 579 Bit Score: 164.57 E-value: 1.53e-45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTkqFMQKNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRK 81
Cdd:COG1132  340 IEFENVS--FSYPGDRP--VLKDISLTIPPGETVALVGPSGSGKSTLVNLLLRFYDPTSGRILIDGVDIRDLTLESLRRQ 415

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFpNMTIEENITvvprmLGwdkkRCHARAEELMS---MVALDpkRFLHRYPK-----------EMSGGQQQ 147
Cdd:COG1132  416 IGVVPQDTFLF-SGTIRENIR-----YG----RPDATDEEVEEaakAAQAH--EFIEALPDgydtvvgergvNLSGGQRQ 483

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 148 RIGVIRALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQlkKTVMLVSHD---IDEAlklgDRIAVFRQGKIVQNAS 224
Cdd:COG1132  484 RIAIARALLKDPPILILDEATSALDTETEALIQEALERLMKG--RTTIVIAHRlstIRNA----DRILVLDDGRIVEQGT 557


                 ....*..
gi 727180512 225 ADELLAR 231
Cdd:COG1132  558 HEELLAR 564

PRK11000

maltose/maltodextrin ABC transporter ATP-binding protein MalK;

24-242

1.54e-45

maltose/maltodextrin ABC transporter ATP-binding protein MalK;

Pssm-ID: 182893 [Multi-domain] Cd Length: 369 Bit Score: 160.20 E-value: 1.54e-45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  24 NINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSalDTVSLRRKIGYVIQQIGLFPNMTIEENITV 103
Cdd:PRK11000  21 DINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLEDITSGDLFIGEKRMN--DVPPAERGVGMVFQSYALYPHLSVAENMSF 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 104 VPRMLGWDKKRCHARAEELMSMVALDpkRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRETIQNEF 183
Cdd:PRK11000  99 GLKLAGAKKEEINQRVNQVAEVLQLA--HLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEI 176

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 727180512 184 LDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEFVASFVG 242
Cdd:PRK11000 177 SRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPANRFVAGFIG 235

ABC_Iron-Siderophores_B12_Hemin

cd03214

ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related ...

3-220

3.40e-45

ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC transporter mediating vitamin B12 uptake. The two ATP-binding cassettes (BtuD) are in close contact with each other, as are the two membrane-spanning subunits (BtuC); this arrangement is distinct from that observed for the E. coli lipid flippase MsbA. The BtuC subunits provide 20 transmembrane helices grouped around a translocation pathway that is closed to the cytoplasm by a gate region, whereas the dimer arrangement of the BtuD subunits resembles the ATP-bound form of the Rad50 DNA repair enzyme. A prominent cytoplasmic loop of BtuC forms the contact region with the ATP-binding cassette and represent a conserved motif among the ABC transporters.

Pssm-ID: 213181 [Multi-domain] Cd Length: 180 Bit Score: 153.36 E-value: 3.40e-45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   3 KLENLTKQFMQKNgtpfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRKI 82
Cdd:cd03214    1 EVENLSVGYGGRT-----VLDDLSLSIEAGEIVGILGPNGAGKSTLLKTLAGLLKPSSGEILLDGKDLASLSPKELARKI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  83 GYVIQqiglfpnmtieenitvvprmlgwdkkrcharaeelmSMVALDPKRFLHRYPKEMSGGQQQRIGVIRALAADPPVL 162
Cdd:cd03214   76 AYVPQ------------------------------------ALELLGLAHLADRPFNELSGGERQRVLLARALAQEPPIL 119

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727180512 163 LMDEPFGAVDPINretiQNEFLDMQRQLK----KTVMLVSHDIDEALKLGDRIAVFRQGKIV 220
Cdd:cd03214  120 LLDEPTSHLDIAH----QIELLELLRRLArergKTVVMVLHDLNLAARYADRVILLKDGRIV 177

ModC

COG4148

ABC-type molybdate transport system, ATPase component ModC [Inorganic ion transport and ...

24-233

7.35e-45

ABC-type molybdate transport system, ATPase component ModC [Inorganic ion transport and metabolism]; ABC-type molybdate transport system, ATPase component ModC is part of the Pathway/BioSystem: Molybdopterin biosynthesis

Pssm-ID: 443319 [Multi-domain] Cd Length: 358 Bit Score: 157.96 E-value: 7.35e-45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  24 NINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGE---DTSALDTVSL-RRKIGYVIQQIGLFPNMTIEE 99
Cdd:COG4148   17 DVDFTLPGRGVTALFGPSGSGKTTLLRAIAGLERPDSGRIRLGGEvlqDSARGIFLPPhRRRIGYVFQEARLFPHLSVRG 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 100 NITvvprmLGWdkKRCHARA-----EELMSMVALDPkrFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPI 174
Cdd:COG4148   97 NLL-----YGR--KRAPRAErrisfDEVVELLGIGH--LLDRRPATLSGGERQRVAIGRALLSSPRLLLMDEPLAALDLA 167

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 727180512 175 NRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPA 233
Cdd:COG4148  168 RKAEILPYLERLRDELDIPILYVSHSLDEVARLADHVVLLEQGRVVASGPLAEVLSRPD 226

tauB

PRK11248

taurine ABC transporter ATP-binding subunit;

1-205

8.20e-45

taurine ABC transporter ATP-binding subunit;

Pssm-ID: 183056 [Multi-domain] Cd Length: 255 Bit Score: 154.86 E-value: 8.20e-45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqkNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGedtSALDTVSLRR 80
Cdd:PRK11248   1 MLQISHLYADY---GGKP--ALEDINLTLESGELLVVLGPSGCGKTTLLNLIAGFVPYQHGSITLDG---KPVEGPGAER 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 kiGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDpkRFLHRYPKEMSGGQQQRIGVIRALAADPP 160
Cdd:PRK11248  73 --GVVFQNEGLLPWRNVQDNVAFGLQLAGVEKMQRLEIAHQMLKKVGLE--GAEKRYIWQLSGGQRQRVGIARALAANPQ 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 727180512 161 VLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEAL 205
Cdd:PRK11248 149 LLLLDEPFGALDAFTREQMQTLLLKLWQETGKQVLLITHDIEEAV 193

ABC_YhbG

cd03218

ATP-binding cassette component of YhbG transport system; The ABC transporters belonging to the ...

2-233

1.24e-44

ATP-binding cassette component of YhbG transport system; The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in cell envelope during biogenesis. YhbG is the putative ATP-binding cassette component and YhbN is the putative periplasmic-binding protein. Depletion of each gene product leads to growth arrest, irreversible cell damage and loss of viability in E. coli. The YhbG homolog (NtrA) is essential in Rhizobium meliloti, a symbiotic nitrogen-fixing bacterium.

Pssm-ID: 213185 [Multi-domain] Cd Length: 232 Bit Score: 153.85 E-value: 1.24e-44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFMQKNgtpfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRK 81
Cdd:cd03218    1 LRAENLSKRYGKRK-----VVNGVSLSVKQGEIVGLLGPNGAGKTTTFYMIVGLVKPDSGKILLDGQDITKLPMHKRARL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 -IGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIGVIRALAADPP 160
Cdd:cd03218   76 gIGYLPQEASIFRKLTVEENILAVLEIRGLSKKEREEKLEELLEEFHITHLR--KSKASSLSGGERRRVEIARALATNPK 153

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727180512 161 VLLMDEPFGAVDPINRETIQNefldMQRQLKKT---VMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPA 233
Cdd:cd03218  154 FLLLDEPFAGVDPIAVQDIQK----IIKILKDRgigVLITDHNVRETLSITDRAYIIYEGKVLAEGTPEEIAANEL 225

ABC_drug_resistance_like

cd03264

ABC-type multidrug transport system, ATPase component; The biological function of this family ...

2-222

4.32e-44

ABC-type multidrug transport system, ATPase component; The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213231 [Multi-domain] Cd Length: 211 Bit Score: 151.58 E-value: 4.32e-44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFMQKNgtpfnAVDNINLDVPEGeICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSAlDTVSLRRK 81
Cdd:cd03264    1 LQLENLTKRYGKKR-----ALDGVSLTLGPG-MYGLLGPNGAGKTTLMRILATLTPPSSGTIRIDGQDVLK-QPQKLRRR 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIGVIRALAADPPV 161
Cdd:cd03264   74 IGYLPQEFGVYPNFTVREFLDYIAWLKGIPSKEVKARVDEVLELVNLGDRA--KKKIGSLSGGMRRRVGIAQALVGDPSI 151

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727180512 162 LLMDEPFGAVDPINRetiqNEFLDMQRQL--KKTVMLVSHDIDEALKLGDRIAVFRQGKIVQN 222
Cdd:cd03264  152 LIVDEPTAGLDPEER----IRFRNLLSELgeDRIVILSTHIVEDVESLCNQVAVLNKGKLVFE 210

modC_ABC

TIGR02142

molybdenum ABC transporter, ATP-binding protein; This model represents the ATP-binding ...

25-233

6.71e-44

molybdenum ABC transporter, ATP-binding protein; This model represents the ATP-binding cassette (ABC) protein of the three subunit molybdate ABC transporter. The three proteins of this complex are homologous to proteins of the sulfate ABC transporter. Molybdenum may be used in nitrogenases of nitrogen-fixing bacteria and in molybdopterin cofactors. In some cases, molybdate may be transported by a sulfate transporter rather than by a specific molybdate transporter. [Transport and binding proteins, Anions]

Pssm-ID: 131197 [Multi-domain] Cd Length: 354 Bit Score: 155.27 E-value: 6.71e-44

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   25 INLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGE---DTSA-LDTVSLRRKIGYVIQQIGLFPNMTIEEN 100
Cdd:TIGR02142  16 ADFTLPGQGVTAIFGRSGSGKTTLIRLIAGLTRPDEGEIVLNGRtlfDSRKgIFLPPEKRRIGYVFQEARLFPHLSVRGN 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  101 itvvprmLGWDKKRC-----HARAEELMSMVALDPkrFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPIN 175
Cdd:TIGR02142  96 -------LRYGMKRArpserRISFERVIELLGIGH--LLGRLPGRLSGGEKQRVAIGRALLSSPRLLLMDEPLAALDDPR 166

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 727180512  176 RETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPA 233
Cdd:TIGR02142 167 KYEILPYLERLHAEFGIPILYVSHSLQEVLRLADRVVVLEDGRVAAAGPIAEVWASPD 224

LivF

COG0410

ABC-type branched-chain amino acid transport system, ATPase component LivF [Amino acid ...

21-233

2.52e-43

ABC-type branched-chain amino acid transport system, ATPase component LivF [Amino acid transport and metabolism];

Pssm-ID: 440179 [Multi-domain] Cd Length: 236 Bit Score: 150.52 E-value: 2.52e-43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  21 AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSL-RRKIGYVIQQIGLFPNMTIEE 99
Cdd:COG0410   18 VLHGVSLEVEEGEIVALLGRNGAGKTTLLKAISGLLPPRSGSIRFDGEDITGLPPHRIaRLGIGYVPEGRRIFPSLTVEE 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 100 NItVVPRMLGWDKKRCHARAEELMSMValdP--KRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPInre 177
Cdd:COG0410   98 NL-LLGAYARRDRAEVRADLERVYELF---PrlKERRRQRAGTLSGGEQQMLAIGRALMSRPKLLLLDEPSLGLAPL--- 170

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 727180512 178 tIQNEFLDMQRQLKK---TVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPA 233
Cdd:COG0410  171 -IVEEIFEIIRRLNRegvTILLVEQNARFALEIADRAYVLERGRIVLEGTAAELLADPE 228

LptB

COG1137

ABC-type lipopolysaccharide export system, ATPase component [Cell wall/membrane/envelope ...

1-232

4.67e-43

ABC-type lipopolysaccharide export system, ATPase component [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 440752 [Multi-domain] Cd Length: 240 Bit Score: 149.79 E-value: 4.67e-43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQKNgtpfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDtVSLR- 79
Cdd:COG1137    3 TLEAENLVKSYGKRT-----VVKDVSLEVNQGEIVGLLGPNGAGKTTTFYMIVGLVKPDSGRIFLDGEDITHLP-MHKRa 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  80 RK-IGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIGVIRALAAD 158
Cdd:COG1137   77 RLgIGYLPQEASIFRKLTVEDNILAVLELRKLSKKEREERLEELLEEFGITHLR--KSKAYSLSGGERRRVEIARALATN 154

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 727180512 159 PPVLLMDEPFGAVDPINRETIQneflDMQRQLKKT---VMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARP 232
Cdd:COG1137  155 PKFILLDEPFAGVDPIAVADIQ----KIIRHLKERgigVLITDHNVRETLGICDRAYIISEGKVLAEGTPEEILNNP 227

PRK14247

phosphate ABC transporter ATP-binding protein; Provisional

22-241

5.66e-43

phosphate ABC transporter ATP-binding protein; Provisional

Pssm-ID: 172735 [Multi-domain] Cd Length: 250 Bit Score: 150.06 E-value: 5.66e-43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  22 VDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIE-----PTGGTILINGEDTSALDTVSLRRKIGYVIQQIGLFPNMT 96
Cdd:PRK14247  19 LDGVNLEIPDNTITALMGPSGSGKSTLLRVFNRLIElypeaRVSGEVYLDGQDIFKMDVIELRRRVQMVFQIPNPIPNLS 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  97 IEENITVVPRM--LGWDKKRCHARAEELMSMVAL--DPKRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVD 172
Cdd:PRK14247  99 IFENVALGLKLnrLVKSKKELQERVRWALEKAQLwdEVKDRLDAPAGKLSGGQQQRLCIARALAFQPEVLLADEPTANLD 178

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 727180512 173 PINRETIQNEFLDMQRQLkkTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEFVASFV 241
Cdd:PRK14247 179 PENTAKIESLFLELKKDM--TIVLVTHFPQQAARISDYVAFLYKGQIVEWGPTREVFTNPRHELTEKYV 245

CydD

COG4988

ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease ...

2-231

1.53e-42

ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 444012 [Multi-domain] Cd Length: 563 Bit Score: 156.07 E-value: 1.53e-42

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTkqFMQKNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRK 81
Cdd:COG4988  337 IELEDVS--FSYPGGRP--ALDGLSLTIPPGERVALVGPSGAGKSTLLNLLLGFLPPYSGSILINGVDLSDLDPASWRRQ 412

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPnMTIEENITvvprmLGwdkkRCHARAEELMS---MVALDpkRFLHRYPKEM-----------SGGQQQ 147
Cdd:COG4988  413 IAWVPQNPYLFA-GTIRENLR-----LG----RPDASDEELEAaleAAGLD--EFVAALPDGLdtplgeggrglSGGQAQ 480

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 148 RIGVIRALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQlkKTVMLVSHDIdEALKLGDRIAVFRQGKIVQNASADE 227
Cdd:COG4988  481 RLALARALLRDAPLLLLDEPTAHLDAETEAEILQALRRLAKG--RTVILITHRL-ALLAQADRILVLDDGRIVEQGTHEE 557


                 ....
gi 727180512 228 LLAR 231
Cdd:COG4988  558 LLAK 561

PRK13651

cobalt transporter ATP-binding subunit; Provisional

2-230

3.22e-42

cobalt transporter ATP-binding subunit; Provisional

Pssm-ID: 184210 [Multi-domain] Cd Length: 305 Bit Score: 149.85 E-value: 3.22e-42

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFMQKNGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGED----------TS 71
Cdd:PRK13651   3 IKVKNIVKIFNKKLPTELKALDNVSVEINQGEFIAIIGQTGSGKTTFIEHLNALLLPDTGTIEWIFKDeknkkktkekEK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  72 ALDTV--------------SLRRKIGYVIQ--QIGLFPNmTIEENITVVPRMLGWDKKRCHARAEELMSMVALdPKRFLH 135
Cdd:PRK13651  83 VLEKLviqktrfkkikkikEIRRRVGVVFQfaEYQLFEQ-TIEKDIIFGPVSMGVSKEEAKKRAAKYIELVGL-DESYLQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 136 RYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQlKKTVMLVSHDIDEALKLGDRIAVFR 215
Cdd:PRK13651 161 RSPFELSGGQKRRVALAGILAMEPDFLVFDEPTAGLDPQGVKEILEIFDNLNKQ-GKTIILVTHDLDNVLEWTKRTIFFK 239

                        250
                 ....*....|....*
gi 727180512 216 QGKIVQNASADELLA 230
Cdd:PRK13651 240 DGKIIKDGDTYDILS 254

ABC_FtsE

cd03292

Cell division ATP-binding protein FtsE; The FtsEX complex resembles an ABC transporter, where ...

2-219

9.66e-42

Cell division ATP-binding protein FtsE; The FtsEX complex resembles an ABC transporter, where FtsE is the ATPase and the membrane subunit FtsX resembles a permease subunit. But rather than transporting any substrate, the complex acts in cell division by undergoing conformational changes that alter the activity of cell wall hydrolases located outside the plasma membrane. The complex is widely conserved in bacteria, but also extremely divergent in sequence between different lineages

Pssm-ID: 213259 [Multi-domain] Cd Length: 214 Bit Score: 145.63 E-value: 9.66e-42

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFmqKNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALD---TVSL 78
Cdd:cd03292    1 IEFINVTKTY--PNGTA--ALDGINISISAGEFVFLVGPSGAGKSTLLKLIYKEELPTSGTIRVNGQDVSDLRgraIPYL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  79 RRKIGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIGVIRALAAD 158
Cdd:cd03292   77 RRKIGVVFQDFRLLPDRNVYENVAFALEVTGVPPREIRKRVPAALELVGLSHKH--RALPAELSGGEQQRVAIARAIVNS 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727180512 159 PPVLLMDEPFGAVDPINRETIQNEFLDMQrQLKKTVMLVSHDIDEALKLGDRIAVFRQGKI 219
Cdd:cd03292  155 PTILIADEPTGNLDPDTTWEIMNLLKKIN-KAGTTVVVATHAKELVDTTRHRVIALERGKL 214

ABC_Metallic_Cations

cd03235

ATP-binding cassette domain of the metal-type transporters; This family includes transporters ...

3-219

1.81e-41

ATP-binding cassette domain of the metal-type transporters; This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-siderophore uptake family suggesting that they share a common ancestor. The best characterized metal-type ABC transporters are the YfeABCD system of Y. pestis, the SitABCD system of Salmonella enterica serovar Typhimurium, and the SitABCD transporter of Shigella flexneri. Moreover other uncharacterized homologs of these metal-type transporters are mainly found in pathogens like Haemophilus or enteroinvasive E. coli isolates.

Pssm-ID: 213202 [Multi-domain] Cd Length: 213 Bit Score: 144.98 E-value: 1.81e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   3 KLENLTKQFMQKNgtpfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALdtvslRRKI 82
Cdd:cd03235    1 EVEDLTVSYGGHP-----VLEDVSFEVKPGEFLAIVGPNGAGKSTLLKAILGLLKPTSGSIRVFGKPLEKE-----RKRI 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  83 GYVIQQIGL---FPnMTIEEnitVV-------PRMLGWDKKRCHARAEELMSMVALdpKRFLHRYPKEMSGGQQQRIGVI 152
Cdd:cd03235   71 GYVPQRRSIdrdFP-ISVRD---VVlmglyghKGLFRRLSKADKAKVDEALERVGL--SELADRQIGELSGGQQQRVLLA 144

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 153 RALAADPPVLLMDEPFGAVDPINretiQNEFLDMQRQLK---KTVMLVSHDIDEALKLGDRIAVFRQGKI 219
Cdd:cd03235  145 RALVQDPDLLLLDEPFAGVDPKT----QEDIYELLRELRregMTILVVTHDLGLVLEYFDRVLLLNRTVV 210

L_ocin_972_ABC

TIGR03608

putative bacteriocin export ABC transporter, lactococcin 972 group; A gene pair with a fairly ...

4-211

4.12e-41

putative bacteriocin export ABC transporter, lactococcin 972 group; A gene pair with a fairly wide distribution consists of a polypeptide related to the lactococcin 972 (see TIGR01653) and multiple-membrane-spanning putative immunity protein (see TIGR01654). This model represents a small clade within the ABC transporters that regularly are found adjacent to these bacteriocin system gene pairs and are likely serve as export proteins. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]

Pssm-ID: 188353 [Multi-domain] Cd Length: 206 Bit Score: 143.52 E-value: 4.12e-41

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512    4 LENLTKQFMQKNgtpfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVS----LR 79
Cdd:TIGR03608   1 LKNISKKFGDKV-----ILDDLNLTIEKGKMYAIIGESGSGKSTLLNIIGLLEKFDSGQVYLNGQETPPLNSKKaskfRR 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   80 RKIGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKrfLHRYPKEMSGGQQQRIGVIRALAADP 159
Cdd:TIGR03608  76 EKLGYLFQNFALIENETVEENLDLGLKYKKLSKKEKREKKKEALEKVGLNLK--LKQKIYELSGGEQQRVALARAILKPP 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 727180512  160 PVLLMDEPFGAVDPINRETIQNEFLDMQRQlKKTVMLVSHDIdEALKLGDRI 211
Cdd:TIGR03608 154 PLILADEPTGSLDPKNRDEVLDLLLELNDE-GKTIIIVTHDP-EVAKQADRV 203

MglA

COG1129

ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism];

1-244

4.52e-41

ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism];

Pssm-ID: 440745 [Multi-domain] Cd Length: 497 Bit Score: 150.94 E-value: 4.52e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqkNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTV-SLR 79
Cdd:COG1129    4 LLEMRGISKSF---GGVK--ALDGVSLELRPGEVHALLGENGAGKSTLMKILSGVYQPDSGEILLDGEPVRFRSPRdAQA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  80 RKIGYVIQQIGLFPNMTIEENITV--VPRMLGW-DKKRCHARAEELMSMV--ALDPKRFLhrypKEMSGGQQQRIGVIRA 154
Cdd:COG1129   79 AGIAIIHQELNLVPNLSVAENIFLgrEPRRGGLiDWRAMRRRARELLARLglDIDPDTPV----GDLSVAQQQLVEIARA 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 155 LAADPPVLLMDEPFGAVDPinRETiqNEFLDMQRQLKK---TVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELlar 231
Cdd:COG1129  155 LSRDARVLILDEPTASLTE--REV--ERLFRIIRRLKAqgvAIIYISHRLDEVFEIADRVTVLRDGRLVGTGPVAEL--- 227

                        250
                 ....*....|...
gi 727180512 232 PANEFVASFVGQD 244
Cdd:COG1129  228 TEDELVRLMVGRE 240

ABC_ThiQ_thiamine_transporter

cd03298

ATP-binding cassette domain of the thiamine transport system; Part of the ...

7-220

4.74e-41

ATP-binding cassette domain of the thiamine transport system; Part of the binding-protein-dependent transport system tbpA-thiPQ for thiamine and TPP. Probably responsible for the translocation of thiamine across the membrane. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213265 [Multi-domain] Cd Length: 211 Bit Score: 143.79 E-value: 4.74e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   7 LTKQFMQKNGTPFNavdnINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVslRRKIGYVI 86
Cdd:cd03298    3 LDKIRFSYGEQPMH----FDLTFAQGEITAIVGPSGSGKSTLLNLIAGFETPQSGRVLINGVDVTAAPPA--DRPVSMLF 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  87 QQIGLFPNMTIEENIT--VVP--RMLGWDKKRCHARAEElmsmVALDpkRFLHRYPKEMSGGQQQRIGVIRALAADPPVL 162
Cdd:cd03298   77 QENNLFAHLTVEQNVGlgLSPglKLTAEDRQAIEVALAR----VGLA--GLEKRLPGELSGGERQRVALARVLVRDKPVL 150

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 727180512 163 LMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIV 220
Cdd:cd03298  151 LLDEPFAALDPALRAEMLDLVLDLHAETKMTVLMVTHQPEDAKRLAQRVVFLDNGRIA 208

YejF

COG4172

ABC-type microcin C transport system, duplicated ATPase component YejF [Secondary metabolites ...

2-235

6.01e-41

ABC-type microcin C transport system, duplicated ATPase component YejF [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 443332 [Multi-domain] Cd Length: 533 Bit Score: 150.99 E-value: 6.01e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFMQKNG------TPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIePTGGTILINGEDTSALDT 75
Cdd:COG4172  276 LEARDLKVWFPIKRGlfrrtvGHVKAVDGVSLTLRRGETLGLVGESGSGKSTLGLALLRLI-PSEGEIRFDGQDLDGLSR 354

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  76 ---VSLRRKIgyviqQI-------GLFPNMTIEENIT---VVPRMlGWDKKRCHARAEELMSMVALDPkRFLHRYPKEMS 142
Cdd:COG4172  355 ralRPLRRRM-----QVvfqdpfgSLSPRMTVGQIIAeglRVHGP-GLSAAERRARVAEALEEVGLDP-AARHRYPHEFS 427

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 143 GGQQQRIGVIRALAADPPVLLMDEPFGAVDpinrETIQNEFLDMQRQLKK----TVMLVSHDideaLK----LGDRIAVF 214
Cdd:COG4172  428 GGQRQRIAIARALILEPKLLVLDEPTSALD----VSVQAQILDLLRDLQRehglAYLFISHD----LAvvraLAHRVMVM 499

                        250       260
                 ....*....|....*....|.
gi 727180512 215 RQGKIVQNASADELLARPANE 235
Cdd:COG4172  500 KDGKVVEQGPTEQVFDAPQHP 520

PRK14239

phosphate transporter ATP-binding protein; Provisional

21-235

6.76e-41

phosphate transporter ATP-binding protein; Provisional

Pssm-ID: 184585 [Multi-domain] Cd Length: 252 Bit Score: 144.53 E-value: 6.76e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  21 AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRL--IEP---TGGTILINGEDTSA--LDTVSLRRKIGYVIQQIGLFP 93
Cdd:PRK14239  20 ALNSVSLDFYPNEITALIGPSGSGKSTLLRSINRMndLNPevtITGSIVYNGHNIYSprTDTVDLRKEIGMVFQQPNPFP 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  94 nMTIEENITVVPRMLGW-DKKRCHARAEELMSMVAL--DPKRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGA 170
Cdd:PRK14239 100 -MSIYENVVYGLRLKGIkDKQVLDEAVEKSLKGASIwdEVKDRLHDSALGLSGGQQQRVCIARVLATSPKIILLDEPTSA 178

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727180512 171 VDPINRETIQNEFLDMQRQLkkTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANE 235
Cdd:PRK14239 179 LDPISAGKIEETLLGLKDDY--TMLLVTRSMQQASRISDRTGFFLDGDLIEYNDTKQMFMNPKHK 241

cbiO

PRK13645

energy-coupling factor transporter ATPase;

2-230

1.73e-40

energy-coupling factor transporter ATPase;

Pssm-ID: 184204 [Multi-domain] Cd Length: 289 Bit Score: 144.77 E-value: 1.73e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFMQKNGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRL-IEPTGGTILINGEDTSALDTVS--- 77
Cdd:PRK13645   7 IILDNVSYTYAKKTPFEFKALNNTSLTFKKNKVTCVIGTTGSGKSTMIQLTNGLiISETGQTIVGDYAIPANLKKIKevk 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  78 -LRRKIGYVIQ--QIGLFPNmTIEENITVVPRMLGWDKKRCHARAEELMSMVALdPKRFLHRYPKEMSGGQQQRIGVIRA 154
Cdd:PRK13645  87 rLRKEIGLVFQfpEYQLFQE-TIEKDIAFGPVNLGENKQEAYKKVPELLKLVQL-PEDYVKRSPFELSGGQKRRVALAGI 164

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727180512 155 LAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLA 230
Cdd:PRK13645 165 IAMDGNTLVLDEPTGGLDPKGEEDFINLFERLNKEYKKRIIMVTHNMDQVLRIADEVIVMHEGKVISIGSPFEIFS 240

CcmA

COG4133

ABC-type transport system involved in cytochrome c biogenesis, ATPase component ...

1-210

1.91e-40

ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 443308 [Multi-domain] Cd Length: 206 Bit Score: 141.85 E-value: 1.91e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqkNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSAlDTVSLRR 80
Cdd:COG4133    2 MLEAENLSCRR---GERL--LFSGLSFTLAAGEALALTGPNGSGKTTLLRILAGLLPPSAGEVLWNGEPIRD-AREDYRR 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRchARAEELMSMVALDPkrFLHRYPKEMSGGQQQRIGVIRALAADPP 160
Cdd:COG4133   76 RLAYLGHADGLKPELTVRENLRFWAALYGLRADR--EAIDEALEAVGLAG--LADLPVRQLSAGQKRRVALARLLLSPAP 151

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 727180512 161 VLLMDEPFGAVDPINRETIQnEFLDMQRQLKKTVMLVSHDIDEA-----LKLGDR 210
Cdd:COG4133  152 LWLLDEPFTALDAAGVALLA-ELIAAHLARGGAVLLTTHQPLELaaarvLDLGDF 205

YbbA

COG4181

Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase ...

1-227

3.61e-40

Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 443338 [Multi-domain] Cd Length: 233 Bit Score: 142.19 E-value: 3.61e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQkNGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSL-- 78
Cdd:COG4181    8 IIELRGLTKTVGT-GAGELTILKGISLEVEAGESVAIVGASGSGKSTLLGLLAGLDRPTSGTVRLAGQDLFALDEDARar 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  79 --RRKIGYVIQQIGLFPNMTIEENITVvPRMLGwDKKRCHARAEELMSMVALDpKRfLHRYPKEMSGGQQQRIGVIRALA 156
Cdd:COG4181   87 lrARHVGFVFQSFQLLPTLTALENVML-PLELA-GRRDARARARALLERVGLG-HR-LDHYPAQLSGGEQQRVALARAFA 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727180512 157 ADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLgDRIAVFRQGKIVQNASADE 227
Cdd:COG4181  163 TEPAILFADEPTGNLDAATGEQIIDLLFELNRERGTTLVLVTHDPALAARC-DRVLRLRAGRLVEDTAATA 232

thiQ

PRK10771

thiamine ABC transporter ATP-binding protein ThiQ;

1-235

4.73e-40

thiamine ABC transporter ATP-binding protein ThiQ;

Pssm-ID: 182716 [Multi-domain] Cd Length: 232 Bit Score: 141.64 E-value: 4.73e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLT----KQFMQkngtpfnavdnINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSAldTV 76
Cdd:PRK10771   1 MLKLTDITwlyhHLPMR-----------FDLTVERGERVAILGPSGAGKSTLLNLIAGFLTPASGSLTLNGQDHTT--TP 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  77 SLRRKIGYVIQQIGLFPNMTIEENITvvprmLGWDK--KRCHARAEELMSM---VALDPkrFLHRYPKEMSGGQQQRIGV 151
Cdd:PRK10771  68 PSRRPVSMLFQENNLFSHLTVAQNIG-----LGLNPglKLNAAQREKLHAIarqMGIED--LLARLPGQLSGGQRQRVAL 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 152 IRALAADPPVLLMDEPFGAVDPINRetiqNEFLDM------QRQLkkTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASA 225
Cdd:PRK10771 141 ARCLVREQPILLLDEPFSALDPALR----QEMLTLvsqvcqERQL--TLLMVSHSLEDAARIAPRSLVVADGRIAWDGPT 214

                        250
                 ....*....|
gi 727180512 226 DELLARPANE 235
Cdd:PRK10771 215 DELLSGKASA 224

ntrCD

TIGR01184

nitrate transport ATP-binding subunits C and D; This model describes the ATP binding subunits ...

22-217

5.21e-40

nitrate transport ATP-binding subunits C and D; This model describes the ATP binding subunits of nitrate transport in bacteria and archaea. This protein belongs to the ATP-binding cassette (ABC) superfamily. It is thought that the two subunits encoded by ntrC and ntrD form the binding surface for interaction with ATP. This model is restricted in identifying ATP binding subunit associated with the nitrate transport. Nitrate assimilation is aided by other proteins derived from the operon which among others include products of ntrA - a regulatory protein; ntrB - a hydropbobic transmembrane permease and narB - a reductase. [Transport and binding proteins, Anions, Transport and binding proteins, Other]

Pssm-ID: 130252 [Multi-domain] Cd Length: 230 Bit Score: 141.45 E-value: 5.21e-40

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   22 VDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDtsaLDTVSLRRKIgyVIQQIGLFPNMTIEENI 101
Cdd:TIGR01184   1 LKGVNLTIQQGEFISLIGHSGCGKSTLLNLISGLAQPTSGGVILEGKQ---ITEPGPDRMV--VFQNYSLLPWLTVRENI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  102 TVVPRMLGWDKKRCHARA--EELMSMVALdpKRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRETI 179
Cdd:TIGR01184  76 ALAVDRVLPDLSKSERRAivEEHIALVGL--TEAADKRPGQLSGGMKQRVAIARALSIRPKVLLLDEPFGALDALTRGNL 153

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 727180512  180 QNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQG 217
Cdd:TIGR01184 154 QEELMQIWEEHRVTVLMVTHDVDEALLLSDRVVMLTNG 191

YnjD

COG4136

ABC-type uncharacterized transport system YnjBCD, ATPase component [General function ...

1-205

2.32e-39

ABC-type uncharacterized transport system YnjBCD, ATPase component [General function prediction only];

Pssm-ID: 443311 [Multi-domain] Cd Length: 211 Bit Score: 139.15 E-value: 2.32e-39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTkqfMQKNGTPFnaVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEP---TGGTILINGEDTSALDTvs 77
Cdd:COG4136    1 MLSLENLT---ITLGGRPL--LAPLSLTVAPGEILTLMGPSGSGKSTLLAAIAGTLSPafsASGEVLLNGRRLTALPA-- 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  78 LRRKIGYVIQQIGLFPNMTIEENITV-VPRMLGWDKKRchARAEELMSMVALDPkrFLHRYPKEMSGGQQQRIGVIRALA 156
Cdd:COG4136   74 EQRRIGILFQDDLLFPHLSVGENLAFaLPPTIGRAQRR--ARVEQALEEAGLAG--FADRDPATLSGGQRARVALLRALL 149

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 727180512 157 ADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEAL 205
Cdd:COG4136  150 AEPRALLLDEPFSKLDAALRAQFREFVFEQIRQRGIPALLVTHDEEDAP 198

LPS_export_lptB

TIGR04406

LPS export ABC transporter ATP-binding protein; Members of this fmaily are LptB, the ...

2-232

9.61e-39

LPS export ABC transporter ATP-binding protein; Members of this fmaily are LptB, the ATP-binding cassette protein of an ABC transporter involved in lipopolysaccharide export. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides, Transport and binding proteins, Other]

Pssm-ID: 275199 [Multi-domain] Cd Length: 239 Bit Score: 138.56 E-value: 9.61e-39

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512    2 IKLENLTKQFMQKNgtpfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVS-LRR 80
Cdd:TIGR04406   2 LVAENLIKSYKKRK-----VVNDVSLSVKSGEIVGLLGPNGAGKTTSFYMIVGLVRPDAGKILIDGQDITHLPMHErARL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   81 KIGYVIQQIGLFPNMTIEENI-TVVPRMLGWDKKRCHARAEELMSMVALdpKRFLHRYPKEMSGGQQQRIGVIRALAADP 159
Cdd:TIGR04406  77 GIGYLPQEASIFRKLTVEENImAVLEIRKDLDRAEREERLEALLEEFQI--SHLRDNKAMSLSGGERRRVEIARALATNP 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727180512  160 PVLLMDEPFGAVDPINRETIQN--EFLdmqRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARP 232
Cdd:TIGR04406 155 KFILLDEPFAGVDPIAVGDIKKiiKHL---KERGIGVLITDHNVRETLDICDRAYIISDGKVLAEGTPAEIVANE 226

HisP

COG4598

ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism];

25-240

1.17e-38

ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism];

Pssm-ID: 443652 [Multi-domain] Cd Length: 259 Bit Score: 138.78 E-value: 1.17e-38

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  25 INLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGE---------------DTSALDtvSLRRKIGYVIQQI 89
Cdd:COG4598   27 VSLTARKGDVISIIGSSGSGKSTFLRCINLLETPDSGEIRVGGEeirlkpdrdgelvpaDRRQLQ--RIRTRLGMVFQSF 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  90 GLFPNMTIEENITVVP-RMLGWDKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPF 168
Cdd:COG4598  105 NLWSHMTVLENVIEAPvHVLGRPKAEAIERAEALLAKVGLADKR--DAYPAHLSGGQQQRAAIARALAMEPEVMLFDEPT 182

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727180512 169 GAVDPinrETIQnEFLDMQRQLK---KTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEFVASF 240
Cdd:COG4598  183 SALDP---ELVG-EVLKVMRDLAeegRTMLVVTHEMGFARDVSSHVVFLHQGRIEEQGPPAEVFGNPKSERLRQF 253

PRK14246

phosphate ABC transporter ATP-binding protein; Provisional

24-241

1.33e-38

phosphate ABC transporter ATP-binding protein; Provisional

Pssm-ID: 172734 [Multi-domain] Cd Length: 257 Bit Score: 138.64 E-value: 1.33e-38

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  24 NINLDVPEGEICVLLGPSGCGKTTTLKMINRLIE------PTGGTILINGEDTSALDTVSLRRKIGYVIQQIGLFPNMTI 97
Cdd:PRK14246  28 DITIKIPNNSIFGIMGPSGSGKSTLLKVLNRLIEiydskiKVDGKVLYFGKDIFQIDAIKLRKEVGMVFQQPNPFPHLSI 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  98 EENITVVPRMLGW-DKKRCHARAEELMSMVALDPKRF--LHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPI 174
Cdd:PRK14246 108 YDNIAYPLKSHGIkEKREIKKIVEECLRKVGLWKEVYdrLNSPASQLSGGQQQRLTIARALALKPKVLLMDEPTSMIDIV 187

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 727180512 175 NRETIQNEFLDMQRQLkkTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEFVASFV 241
Cdd:PRK14246 188 NSQAIEKLITELKNEI--AIVIVSHNPQQVARVADYVAFLYNGELVEWGSSNEIFTSPKNELTEKYV 252

PhnL

COG4778

Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnL [Inorganic ion ...

1-211

2.36e-38

Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnL [Inorganic ion transport and metabolism];

Pssm-ID: 443809 [Multi-domain] Cd Length: 229 Bit Score: 137.18 E-value: 2.36e-38

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFM--QKNGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDT-------S 71
Cdd:COG4778    4 LLEVENLSKTFTlhLQGGKRLPVLDGVSFSVAAGECVALTGPSGAGKSTLLKCIYGNYLPDSGSILVRHDGGwvdlaqaS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  72 ALDTVSLRRK-IGYVIQqiglFpnmtieenITVVPRM------------LGWDKKRCHARAEELMSMVALdPKRFLHRYP 138
Cdd:COG4778   84 PREILALRRRtIGYVSQ----F--------LRVIPRVsaldvvaeplleRGVDREEARARARELLARLNL-PERLWDLPP 150

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727180512 139 KEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRETIqnefLDMQRQLKK--TVML-VSHDIDEALKLGDRI 211
Cdd:COG4778  151 ATFSGGEQQRVNIARGFIADPPLLLLDEPTASLDAANRAVV----VELIEEAKArgTAIIgIFHDEEVREAVADRV 222

cbiO

PRK13634

cobalt transporter ATP-binding subunit; Provisional

16-233

4.92e-38

cobalt transporter ATP-binding subunit; Provisional

Pssm-ID: 237454 [Multi-domain] Cd Length: 290 Bit Score: 138.23 E-value: 4.92e-38

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  16 GTPFN--AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILInGED-----TSALDTVSLRRKIGYVIQq 88
Cdd:PRK13634  15 KTPFErrALYDVNVSIPSGSYVAIIGHTGSGKSTLLQHLNGLLQPTSGTVTI-GERvitagKKNKKLKPLRKKVGIVFQ- 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  89 iglFPNM-----TIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKrFLHRYPKEMSGGQQQRIGVIRALAADPPVLL 163
Cdd:PRK13634  93 ---FPEHqlfeeTVEKDICFGPMNFGVSEEDAKQKAREMIELVGLPEE-LLARSPFELSGGQMRRVAIAGVLAMEPEVLV 168

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 164 MDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPA 233
Cdd:PRK13634 169 LDEPTAGLDPKGRKEMMEMFYKLHKEKGLTTVLVTHSMEDAARYADQIVVMHKGTVFLQGTPREIFADPD 238

met_CoM_red_A2

TIGR03269

methyl coenzyme M reductase system, component A2; The enzyme that catalyzes the final step in ...

1-230

5.95e-38

methyl coenzyme M reductase system, component A2; The enzyme that catalyzes the final step in methanogenesis, methyl coenzyme M reductase, contains alpha, beta, and gamma chains. In older literature, the complex of alpha, beta, and gamma chains was termed component C, while this single chain protein was termed methyl coenzyme M reductase system component A2. [Energy metabolism, Methanogenesis]

Pssm-ID: 132313 [Multi-domain] Cd Length: 520 Bit Score: 143.02 E-value: 5.95e-38

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512    1 MIKLENLTKQFMQKNGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILIN-GEDTsaLDTVSLR 79
Cdd:TIGR03269 279 IIKVRNVSKRYISVDRGVVKAVDNVSLEVKEGEIFGIVGTSGAGKTTLSKIIAGVLEPTSGEVNVRvGDEW--VDMTKPG 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   80 --------RKIGYVIQQIGLFPNMTIEENITvvpRMLGWD--KKRCHARAEELMSMVALDPKR---FLHRYPKEMSGGQQ 146
Cdd:TIGR03269 357 pdgrgrakRYIGILHQEYDLYPHRTVLDNLT---EAIGLElpDELARMKAVITLKMVGFDEEKaeeILDKYPDELSEGER 433

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  147 QRIGVIRALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASAD 226
Cdd:TIGR03269 434 HRVALAQVLIKEPRIVILDEPTGTMDPITKVDVTHSILKAREEMEQTFIIVSHDMDFVLDVCDRAALMRDGKIVKIGDPE 513


                  ....
gi 727180512  227 ELLA 230
Cdd:TIGR03269 514 EIVE 517

ABCC_bacteriocin_exporters

cd03245

ATP-binding cassette domain of bacteriocin exporters, subfamily C; Many non-lantibiotic ...

15-220

7.23e-38

ATP-binding cassette domain of bacteriocin exporters, subfamily C; Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors which have N-terminal leader peptides that share similarities in amino acid sequence and contain a conserved processing site of two glycine residues in positions -1 and -2. A dedicated ATP-binding cassette (ABC) transporter is responsible for the proteolytic cleavage of the leader peptides and subsequent translocation of the bacteriocins across the cytoplasmic membrane.

Pssm-ID: 213212 [Multi-domain] Cd Length: 220 Bit Score: 135.79 E-value: 7.23e-38

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  15 NGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRKIGYVIQQIGLFpN 94
Cdd:cd03245   13 PNQEIPALDNVSLTIRAGEKVAIIGRVGSGKSTLLKLLAGLYKPTSGSVLLDGTDIRQLDPADLRRNIGYVPQDVTLF-Y 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  95 MTIEENITVvprmlgwdkKRCHARAEELM--SMVA-LDPkrFLHRYPKEM-----------SGGQQQRIGVIRALAADPP 160
Cdd:cd03245   92 GTLRDNITL---------GAPLADDERILraAELAgVTD--FVNKHPNGLdlqigergrglSGGQRQAVALARALLNDPP 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727180512 161 VLLMDEPFGAVDpinrETIQNEFLDMQRQLK--KTVMLVSHDIdEALKLGDRIAVFRQGKIV 220
Cdd:cd03245  161 ILLLDEPTSAMD----MNSEERLKERLRQLLgdKTLIIITHRP-SLLDLVDRIIVMDSGRIV 217

YejF

COG4172

ABC-type microcin C transport system, duplicated ATPase component YejF [Secondary metabolites ...

1-233

1.36e-37

ABC-type microcin C transport system, duplicated ATPase component YejF [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 443332 [Multi-domain] Cd Length: 533 Bit Score: 142.13 E-value: 1.36e-37

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQKNGTpFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEP----TGGTILINGEDTSALDTV 76
Cdd:COG4172    6 LLSVEDLSVAFGQGGGT-VEAVKGVSFDIAAGETLALVGESGSGKSVTALSILRLLPDpaahPSGSILFDGQDLLGLSER 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  77 SLRR----KIGYVIQQ--IGLFPNMTIEENITVVPRM-LGWDKKRCHARAEELMSMVAL-DPKRFLHRYPKEMSGGQQQR 148
Cdd:COG4172   85 ELRRirgnRIAMIFQEpmTSLNPLHTIGKQIAEVLRLhRGLSGAAARARALELLERVGIpDPERRLDAYPHQLSGGQRQR 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 149 IGVIRALAADPPVLLMDEPFGAVDPinreTIQNEFL----DMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNAS 224
Cdd:COG4172  165 VMIAMALANEPDLLIADEPTTALDV----TVQAQILdllkDLQRELGMALLLITHDLGVVRRFADRVAVMRQGEIVEQGP 240


                 ....*....
gi 727180512 225 ADELLARPA 233
Cdd:COG4172  241 TAELFAAPQ 249

ABCC_MsbA

cd03251

ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; ...

15-231

1.64e-37

ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213218 [Multi-domain] Cd Length: 234 Bit Score: 135.05 E-value: 1.64e-37

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  15 NGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRKIGYVIQQIGLFpN 94
Cdd:cd03251   11 PGDGPPVLRDISLDIPAGETVALVGPSGSGKSTLVNLIPRFYDVDSGRILIDGHDVRDYTLASLRRQIGLVSQDVFLF-N 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  95 MTIEENITVVPRMLGWDKKRCHARAEELMSmvaldpkrFLHRYPK-----------EMSGGQQQRIGVIRALAADPPVLL 163
Cdd:cd03251   90 DTVAENIAYGRPGATREEVEEAARAANAHE--------FIMELPEgydtvigergvKLSGGQRQRIAIARALLKDPPILI 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 727180512 164 MDEPFGAVDPINRETIQNEfldMQRQLK-KTVMLVSHDIdEALKLGDRIAVFRQGKIVQNASADELLAR 231
Cdd:cd03251  162 LDEATSALDTESERLVQAA---LERLMKnRTTFVIAHRL-STIENADRIVVLEDGKIVERGTHEELLAQ 226

ABCC_Glucan_exporter_like

cd03254

ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Glucan ...

2-231

2.44e-37

ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virulence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and lipid export. The MRP-like family, similar to all ABC proteins, have a common four-domain core structure constituted by two membrane-spanning domains each composed of six transmembrane (TM) helices and two nucleotide-binding domains (NBD). ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213221 [Multi-domain] Cd Length: 229 Bit Score: 134.66 E-value: 2.44e-37

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLtkQFMQKNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRK 81
Cdd:cd03254    3 IEFENV--NFSYDEKKP--VLKDINFSIKPGETVAIVGPTGAGKTTLINLLMRFYDPQKGQILIDGIDIRDISRKSLRSM 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPNmTIEENITvvprmLGwdkkRCHARAEELM-SMVALDPKRFLHRYPK-----------EMSGGQQQRI 149
Cdd:cd03254   79 IGVVLQDTFLFSG-TIMENIR-----LG----RPNATDEEVIeAAKEAGAHDFIMKLPNgydtvlgenggNLSQGERQLL 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 150 GVIRALAADPPVLLMDEPFGAVDPINRETIQNeflDMQRQLK-KTVMLVSHDIDeALKLGDRIAVFRQGKIVQNASADEL 228
Cdd:cd03254  149 AIARAMLRDPKILILDEATSNIDTETEKLIQE---ALEKLMKgRTSIIIAHRLS-TIKNADKILVLDDGKIIEEGTHDEL 224


                 ...
gi 727180512 229 LAR 231
Cdd:cd03254  225 LAK 227

NupO

COG3845

ABC-type guanosine uptake system NupNOPQ, ATPase component NupO [Nucleotide transport and ...

1-228

6.25e-37

ABC-type guanosine uptake system NupNOPQ, ATPase component NupO [Nucleotide transport and metabolism];

Pssm-ID: 443055 [Multi-domain] Cd Length: 504 Bit Score: 139.78 E-value: 6.25e-37

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqkngTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGED---TSALDtvS 77
Cdd:COG3845    5 ALELRGITKRF-----GGVVANDDVSLTVRPGEIHALLGENGAGKSTLMKILYGLYQPDSGEILIDGKPvriRSPRD--A 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  78 LRRKIGYVIQQIGLFPNMTIEENItvvprMLGW--------DKKRCHARAEELMSM--VALDPkrflHRYPKEMSGGQQQ 147
Cdd:COG3845   78 IALGIGMVHQHFMLVPNLTVAENI-----VLGLeptkggrlDRKAARARIRELSERygLDVDP----DAKVEDLSVGEQQ 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 148 RIGVIRALAADPPVLLMDEPFGAVDPinRETiqNEFLDMQRQLK---KTVMLVSHDIDEALKLGDRIAVFRQGKIV---- 220
Cdd:COG3845  149 RVEILKALYRGARILILDEPTAVLTP--QEA--DELFEILRRLAaegKSIIFITHKLREVMAIADRVTVLRRGKVVgtvd 224


                 ....*....
gi 727180512 221 -QNASADEL 228
Cdd:COG3845  225 tAETSEEEL 233

fecE

PRK11231

Fe(3+) dicitrate ABC transporter ATP-binding protein FecE;

1-229

7.44e-37

Fe(3+) dicitrate ABC transporter ATP-binding protein FecE;

Pssm-ID: 183044 [Multi-domain] Cd Length: 255 Bit Score: 133.99 E-value: 7.44e-37

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQKNgtpfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRR 80
Cdd:PRK11231   2 TLRTENLTVGYGTKR-----ILNDLSLSLPTGKITALIGPNGCGKSTLLKCFARLLTPQSGTVFLGDKPISMLSSRQLAR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQQiglfpnMTIEENITV--------VPRMLGWDK--KRCHARAEELMSMVALDpkRFLHRYPKEMSGGQQQRIG 150
Cdd:PRK11231  77 RLALLPQH------HLTPEGITVrelvaygrSPWLSLWGRlsAEDNARVNQAMEQTRIN--HLADRRLTDLSGGQRQRAF 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 151 VIRALAADPPVLLMDEPFGAVDpINRetiQNEFLDMQRQLK---KTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADE 227
Cdd:PRK11231 149 LAMVLAQDTPVVLLDEPTTYLD-INH---QVELMRLMRELNtqgKTVVTVLHDLNQASRYCDHLVVLANGHVMAQGTPEE 224


                 ..
gi 727180512 228 LL 229
Cdd:PRK11231 225 VM 226

PRK14267

phosphate ABC transporter ATP-binding protein; Provisional

22-241

2.09e-36

phosphate ABC transporter ATP-binding protein; Provisional

Pssm-ID: 184596 [Multi-domain] Cd Length: 253 Bit Score: 132.66 E-value: 2.09e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  22 VDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIE-----PTGGTILINGED--TSALDTVSLRRKIGYVIQQIGLFPN 94
Cdd:PRK14267  20 IKGVDLKIPQNGVFALMGPSGCGKSTLLRTFNRLLElneeaRVEGEVRLFGRNiySPDVDPIEVRREVGMVFQYPNPFPH 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  95 MTIEENITVVPRM--LGWDKKRCHARAEELMSMVAL--DPKRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGA 170
Cdd:PRK14267 100 LTIYDNVAIGVKLngLVKSKKELDERVEWALKKAALwdEVKDRLNDYPSNLSGGQRQRLVIARALAMKPKILLMDEPTAN 179

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727180512 171 VDPINRETIQNEFLDMQRQLkkTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEFVASFV 241
Cdd:PRK14267 180 IDPVGTAKIEELLFELKKEY--TIVLVTHSPAQAARVSDYVAFLYLGKLIEVGPTRKVFENPEHELTEKYV 248

ABC_cobalt_CbiO_domain2

cd03226

Second domain of the ATP-binding cassette component of cobalt transport system; Domain II of ...

20-220

4.11e-36

Second domain of the ATP-binding cassette component of cobalt transport system; Domain II of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. The CbiMNQO family ABC transport system is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.

Pssm-ID: 213193 [Multi-domain] Cd Length: 205 Bit Score: 130.45 E-value: 4.11e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  20 NAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDtvsLRRKIGYVIQQIG--LFPNmTI 97
Cdd:cd03226   14 EILDDLSLDLYAGEIIALTGKNGAGKTTLAKILAGLIKESSGSILLNGKPIKAKE---RRKSIGYVMQDVDyqLFTD-SV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  98 EENITVVPRMLGWDKkrchARAEELMSMvaLDPKRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRE 177
Cdd:cd03226   90 REELLLGLKELDAGN----EQAETVLKD--LDLYALKERHPLSLSGGQKQRLAIAAALLSGKDLLIFDEPTSGLDYKNME 163

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 727180512 178 TIQNEFLDMQRQlKKTVMLVSHDIDEALKLGDRIAVFRQGKIV 220
Cdd:cd03226  164 RVGELIRELAAQ-GKAVIVITHDYEFLAKVCDRVLLLANGAIV 205

cbiO

PRK13632

cobalt transporter ATP-binding subunit; Provisional

1-229

4.65e-36

cobalt transporter ATP-binding subunit; Provisional

Pssm-ID: 237452 [Multi-domain] Cd Length: 271 Bit Score: 132.42 E-value: 4.65e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTkqFMQKNGTPfNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRR 80
Cdd:PRK13632   7 MIKVENVS--FSYPNSEN-NALKNVSFEINEGEYVAILGHNGSGKSTISKILTGLLKPQSGEIKIDGITISKENLKEIRK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQQ-----IGLfpnmTIEENIT--VVPRMLgwDKKRCHARAEELMSMVALdpKRFLHRYPKEMSGGQQQRIGVIR 153
Cdd:PRK13632  84 KIGIIFQNpdnqfIGA----TVEDDIAfgLENKKV--PPKKMKDIIDDLAKKVGM--EDYLDKEPQNLSGGQKQRVAIAS 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727180512 154 ALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALkLGDRIAVFRQGKIVQNASADELL 229
Cdd:PRK13632 156 VLALNPEIIIFDESTSMLDPKGKREIKKIMVDLRKTRKKTLISITHDMDEAI-LADKVIVFSEGKLIAQGKPKEIL 230

ModF

COG1119

ABC-type molybdenum transport system, ATPase component ModF/photorepair protein PhrA ...

1-229

5.58e-36

ABC-type molybdenum transport system, ATPase component ModF/photorepair protein PhrA [Inorganic ion transport and metabolism];

Pssm-ID: 440736 [Multi-domain] Cd Length: 250 Bit Score: 131.36 E-value: 5.58e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTkqfMQKNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPT-GGTILINGEDTSALDTVSLR 79
Cdd:COG1119    3 LLELRNVT---VRRGGKT--ILDDISWTVKPGEHWAILGPNGAGKSTLLSLITGDLPPTyGNDVRLFGERRGGEDVWELR 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  80 RKIGYV---IQQ-------------------IGLFPNMTIEEnitvvprmlgwdkkrcHARAEELMSMVALDPKRflHRY 137
Cdd:COG1119   78 KRIGLVspaLQLrfprdetvldvvlsgffdsIGLYREPTDEQ----------------RERARELLELLGLAHLA--DRP 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 138 PKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINREtiqnEFLDMQRQL----KKTVMLVSHDIDEALKLGDRIAV 213
Cdd:COG1119  140 FGTLSQGEQRRVLIARALVKDPELLILDEPTAGLDLGARE----LLLALLDKLaaegAPTLVLVTHHVEEIPPGITHVLL 215

                        250
                 ....*....|....*.
gi 727180512 214 FRQGKIVQNASADELL 229
Cdd:COG1119  216 LKDGRVVAAGPKEEVL 231

ABC_MTABC3_MDL1_MDL2

cd03249

ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; MTABC3 ...

23-231

5.87e-36

ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the yeast MDL1 (multidrug resistance-like protein 1) and MDL2 (multidrug resistance-like protein 2) transporters are also included in this CD. MDL1 is an ATP-dependent permease that acts as a high-copy suppressor of ATM1 and is thought to have a role in resistance to oxidative stress. Interestingly, subfamily B is more closely related to the carboxyl-terminal component of subfamily C than the two halves of ABCC molecules are with one another.

Pssm-ID: 213216 [Multi-domain] Cd Length: 238 Bit Score: 131.12 E-value: 5.87e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  23 DNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRKIGYVIQQIGLFpNMTIEENI- 101
Cdd:cd03249   20 KGLSLTIPPGKTVALVGSSGCGKSTVVSLLERFYDPTSGEILLDGVDIRDLNLRWLRSQIGLVSQEPVLF-DGTIAENIr 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 102 ------TVVPRMLGwdkkrchARAEELMSMVALDPKRF---LHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVD 172
Cdd:cd03249   99 ygkpdaTDEEVEEA-------AKKANIHDFIMSLPDGYdtlVGERGSQLSGGQKQRIAIARALLRNPKILLLDEATSALD 171

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 727180512 173 PINRETIQnEFLDmQRQLKKTVMLVSHDIdEALKLGDRIAVFRQGKIVQNASADELLAR 231
Cdd:cd03249  172 AESEKLVQ-EALD-RAMKGRTTIVIAHRL-STIRNADLIAVLQNGQVVEQGTHDELMAQ 227

ABC_ATP_DarD

NF038007

darobactin export ABC transporter ATP-binding protein;

1-219

1.39e-35

darobactin export ABC transporter ATP-binding protein;

Pssm-ID: 411600 [Multi-domain] Cd Length: 218 Bit Score: 129.45 E-value: 1.39e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQKNgTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSAL---DTVS 77
Cdd:NF038007   1 MLNMQNAEKCYITKT-IKTKVLNHLNFSVEKGDFVSIMGPSGSGKSTLLNIIGMFDSLDSGSLTLAGKEVTNLsysQKII 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  78 LRRK-IGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIGVIRALA 156
Cdd:NF038007  80 LRRElIGYIFQSFNLIPHLSIFDNVALPLKYRGVAKKERIERVNQVLNLFGIDNRR--NHKPMQLSGGQQQRVAIARAMV 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 157 ADPPVLLMDEPFGAVDPIN-RETIQnefldmqrQLKK------TVMLVSHDiDEALKLGDRIAVFRQGKI 219
Cdd:NF038007 158 SNPALLLADEPTGNLDSKNaRAVLQ--------QLKYinqkgtTIIMVTHS-DEASTYGNRIINMKDGKL 218

type_I_sec_LssB

TIGR03375

type I secretion system ATPase, LssB family; Type I protein secretion is a system in some ...

2-230

2.17e-35

type I secretion system ATPase, LssB family; Type I protein secretion is a system in some Gram-negative bacteria to export proteins (often proteases) across both inner and outer membranes to the extracellular medium. This is one of three proteins of the type I secretion apparatus. Targeted proteins are not cleaved at the N-terminus, but rather carry signals located toward the extreme C-terminus to direct type I secretion. This model is related to models TIGR01842 and TIGR01846, and to bacteriocin ABC transporters that cleave their substrates during export. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]

Pssm-ID: 274550 [Multi-domain] Cd Length: 694 Bit Score: 137.30 E-value: 2.17e-35

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512    2 IKLENLTKQFmQKNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRK 81
Cdd:TIGR03375 464 IEFRNVSFAY-PGQETP--ALDNVSLTIRPGEKVAIIGRIGSGKSTLLKLLLGLYQPTEGSVLLDGVDIRQIDPADLRRN 540

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   82 IGYVIQQIGLFpNMTIEENITvvprmLGwdkkRCHARAEELM---------SMVALDPKRF---LHRYPKEMSGGQQQRI 149
Cdd:TIGR03375 541 IGYVPQDPRLF-YGTLRDNIA-----LG----APYADDEEILraaelagvtEFVRRHPDGLdmqIGERGRSLSGGQRQAV 610

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  150 GVIRALAADPPVLLMDEPFGAVDpinrETIQNEFLDMQRQL--KKTVMLVSHDIdEALKLGDRIAVFRQGKIVQNASADE 227
Cdd:TIGR03375 611 ALARALLRDPPILLLDEPTSAMD----NRSEERFKDRLKRWlaGKTLVLVTHRT-SLLDLVDRIIVMDNGRIVADGPKDQ 685


                  ...
gi 727180512  228 LLA 230
Cdd:TIGR03375 686 VLE 688

ABC_Carb_Monos_I

cd03216

First domain of the ATP-binding cassette component of monosaccharide transport system; This ...

2-220

4.90e-35

First domain of the ATP-binding cassette component of monosaccharide transport system; This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (such as xylose, arabinose, and ribose), that cannot be broken down to simple sugars by hydrolysis. Pentoses include xylose, arabinose, and ribose. Important hexoses include glucose, galactose, and fructose. In members of the Carb_monos family, the single hydrophobic gene product forms a homodimer while the ABC protein represents a fusion of two nucleotide-binding domains. However, it is assumed that two copies of the ABC domains are present in the assembled transporter.

Pssm-ID: 213183 [Multi-domain] Cd Length: 163 Bit Score: 126.39 E-value: 4.90e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFmqkngTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTV-SLRR 80
Cdd:cd03216    1 LELRGITKRF-----GGVKALDGVSLSVRRGEVHALLGENGAGKSTLMKILSGLYKPDSGEILVDGKEVSFASPRdARRA 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQqiglfpnmtieenitvvprmlgwdkkrcharaeelmsmvaldpkrflhrypkeMSGGQQQRIGVIRALAADPP 160
Cdd:cd03216   76 GIAMVYQ-----------------------------------------------------LSVGERQMVEIARALARNAR 102

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727180512 161 VLLMDEPFGAVDPinRETiqNEFLDMQRQLKK---TVMLVSHDIDEALKLGDRIAVFRQGKIV 220
Cdd:cd03216  103 LLILDEPTAALTP--AEV--ERLFKVIRRLRAqgvAVIFISHRLDEVFEIADRVTVLRDGRVV 161

cbiO

PRK13641

energy-coupling factor transporter ATPase;

2-232

1.51e-34

energy-coupling factor transporter ATPase;

Pssm-ID: 237456 [Multi-domain] Cd Length: 287 Bit Score: 128.79 E-value: 1.51e-34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTkqFMQKNGTPFNA--VDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGE----DTSALDT 75
Cdd:PRK13641   3 IKFENVD--YIYSPGTPMEKkgLDNISFELEEGSFVALVGHTGSGKSTLMQHFNALLKPSSGTITIAGYhitpETGNKNL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  76 VSLRRKIGYVIQ--QIGLFPNmTIEENITVVPRMLGWDKKRCHARAEELMSMVALdPKRFLHRYPKEMSGGQQQRIGVIR 153
Cdd:PRK13641  81 KKLRKKVSLVFQfpEAQLFEN-TVLKDVEFGPKNFGFSEDEAKEKALKWLKKVGL-SEDLISKSPFELSGGQMRRVAIAG 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 727180512 154 ALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQlKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARP 232
Cdd:PRK13641 159 VMAYEPEILCLDEPAAGLDPEGRKEMMQLFKDYQKA-GHTVILVTHNMDDVAEYADDVLVLEHGKLIKHASPKEIFSDK 236

thiQ

TIGR01277

thiamine ABC transporter, ATP-binding protein; This model describes the energy-transducing ...

26-221

1.59e-34

thiamine ABC transporter, ATP-binding protein; This model describes the energy-transducing ATPase subunit ThiQ of the ThiBPQ thiamine (and thiamine pyrophosphate) ABC transporter in several Proteobacteria. This protein is found so far only in Proteobacteria, and is found in complete genomes only if the ThiB and ThiP subunits are also found. [Transport and binding proteins, Other]

Pssm-ID: 130344 [Multi-domain] Cd Length: 213 Bit Score: 126.51 E-value: 1.59e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   26 NLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTsaLDTVSLRRKIGYVIQQIGLFPNMTIEENIT--V 103
Cdd:TIGR01277  18 DLNVADGEIVAIMGPSGAGKSTLLNLIAGFIEPASGSIKVNDQSH--TGLAPYQRPVSMLFQENNLFAHLTVRQNIGlgL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  104 VP--RMLGWDKKRCHARAEElmsmVALDpkRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRETIQN 181
Cdd:TIGR01277  96 HPglKLNAEQQEKVVDAAQQ----VGIA--DYLDRLPEQLSGGQRQRVALARCLVRPNPILLLDEPFSALDPLLREEMLA 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 727180512  182 EFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQ 221
Cdd:TIGR01277 170 LVKQLCSERQRTLLMVTHHLSDARAIASQIAVVSQGKIKV 209

PRK14243

phosphate transporter ATP-binding protein; Provisional

19-241

2.48e-34

phosphate transporter ATP-binding protein; Provisional

Pssm-ID: 184588 [Multi-domain] Cd Length: 264 Bit Score: 127.59 E-value: 2.48e-34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  19 FNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINR---LIEP--TGGTILINGEDTSA--LDTVSLRRKIGYVIQQIGL 91
Cdd:PRK14243  23 FLAVKNVWLDIPKNQITAFIGPSGCGKSTILRCFNRlndLIPGfrVEGKVTFHGKNLYApdVDPVEVRRRIGMVFQKPNP 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  92 FPNmTIEENITVVPRMLGWdKKRCHARAEELMSMVAL--DPKRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFG 169
Cdd:PRK14243 103 FPK-SIYDNIAYGARINGY-KGDMDELVERSLRQAALwdEVKDKLKQSGLSLSGGQQQRLCIARAIAVQPEVILMDEPCS 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 170 AVDPINRETIQneflDMQRQLKK--TVMLVSHDIDEALKLGDRIAVF---------RQGKIVQNASADELLARPANEFVA 238
Cdd:PRK14243 181 ALDPISTLRIE----ELMHELKEqyTIIIVTHNMQQAARVSDMTAFFnveltegggRYGYLVEFDRTEKIFNSPQQQATR 256


                 ...
gi 727180512 239 SFV 241
Cdd:PRK14243 257 DYV 259

ABCC_Protease_Secretion

cd03246

ATP-binding cassette domain of PrtD, subfamily C; This family represents the ABC component of ...

2-219

8.42e-34

ATP-binding cassette domain of PrtD, subfamily C; This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export degradative enzymes by using a type I protein secretion system and lack an N-terminal signal peptide, but contain a C-terminal secretion signal. The Type I secretion apparatus is made up of three components, an ABC transporter, a membrane fusion protein (MFP), and an outer membrane protein (OMP). For the HlyA transporter complex, HlyB (ABC transporter) and HlyD (MFP) reside in the inner membrane of E. coli. The OMP component is TolC, which is thought to interact with the MFP to form a continuous channel across the periplasm from the cytoplasm to the exterior. HlyB belongs to the family of ABC transporters, which are ubiquitous, ATP-dependent transmembrane pumps or channels. The spectrum of transport substrates ranges from inorganic ions, nutrients such as amino acids, sugars, or peptides, hydrophobic drugs, to large polypeptides, such as HlyA.

Pssm-ID: 213213 [Multi-domain] Cd Length: 173 Bit Score: 123.48 E-value: 8.42e-34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTkqFMQKNGTPFnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRK 81
Cdd:cd03246    1 LEVENVS--FRYPGAEPP-VLRNVSFSIEPGESLAIIGPSGSGKSTLARLILGLLRPTSGRVRLDGADISQWDPNELGDH 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPNmTIEENItvvprmlgwdkkrcharaeelmsmvaldpkrflhrypkeMSGGQQQRIGVIRALAADPPV 161
Cdd:cd03246   78 VGYLPQDDELFSG-SIAENI---------------------------------------LSGGQRQRLGLARALYGNPRI 117

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 727180512 162 LLMDEPFGAVDPINRETIQNEFLDMQRQlKKTVMLVSHDIdEALKLGDRIAVFRQGKI 219
Cdd:cd03246  118 LVLDEPNSHLDVEGERALNQAIAALKAA-GATRIVIAHRP-ETLASADRILVLEDGRV 173

cbiO

PRK13646

energy-coupling factor transporter ATPase;

2-230

1.07e-33

energy-coupling factor transporter ATPase;

Pssm-ID: 184205 [Multi-domain] Cd Length: 286 Bit Score: 126.43 E-value: 1.07e-33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFMQknGTPFN--AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILING----EDTSALDT 75
Cdd:PRK13646   3 IRFDNVSYTYQK--GTPYEhqAIHDVNTEFEQGKYYAIVGQTGSGKSTLIQNINALLKPTTGTVTVDDititHKTKDKYI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  76 VSLRRKIGYVIQ--QIGLFPNmTIEENITVVPRMLGWDKKRCHARAEELMSMVALdPKRFLHRYPKEMSGGQQQRIGVIR 153
Cdd:PRK13646  81 RPVRKRIGMVFQfpESQLFED-TVEREIIFGPKNFKMNLDEVKNYAHRLLMDLGF-SRDVMSQSPFQMSGGQMRKIAIVS 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 727180512 154 ALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLA 230
Cdd:PRK13646 159 ILAMNPDIIVLDEPTAGLDPQSKRQVMRLLKSLQTDENKTIILVSHDMNEVARYADEVIVMKEGSIVSQTSPKELFK 235

PRK10619

histidine ABC transporter ATP-binding protein HisP;

25-241

1.41e-33

histidine ABC transporter ATP-binding protein HisP;

Pssm-ID: 182592 [Multi-domain] Cd Length: 257 Bit Score: 125.47 E-value: 1.41e-33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  25 INLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSAL-DT------------VSLRRKIGYVIQQIGL 91
Cdd:PRK10619  24 VSLQANAGDVISIIGSSGSGKSTFLRCINFLEKPSEGSIVVNGQTINLVrDKdgqlkvadknqlRLLRTRLTMVFQHFNL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  92 FPNMTIEENITVVP-RMLGWDKKRCHARAEELMSMVALDpKRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGA 170
Cdd:PRK10619 104 WSHMTVLENVMEAPiQVLGLSKQEARERAVKYLAKVGID-ERAQGKYPVHLSGGQQQRVSIARALAMEPEVLLFDEPTSA 182

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 727180512 171 VDPinreTIQNEFLDMQRQLK---KTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEFVASFV 241
Cdd:PRK10619 183 LDP----ELVGEVLRIMQQLAeegKTMVVVTHEMGFARHVSSHVIFLHQGKIEEEGAPEQLFGNPQSPRLQQFL 252

urea_trans_UrtE

TIGR03410

urea ABC transporter, ATP-binding protein UrtE; Members of this protein family are ABC ...

21-228

1.49e-33

urea ABC transporter, ATP-binding protein UrtE; Members of this protein family are ABC transporter ATP-binding subunits associated with urea transport and metabolism. This protein is found in a conserved five-gene transport operon typically found adjacent to urease genes. It was shown in Cyanobacteria that disruption leads to the loss of high-affinity urea transport activity. [Transport and binding proteins, Amino acids, peptides and amines]

Pssm-ID: 274567 [Multi-domain] Cd Length: 230 Bit Score: 124.56 E-value: 1.49e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   21 AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSL-RRKIGYVIQQIGLFPNMTIEE 99
Cdd:TIGR03410  15 ILRGVSLEVPKGEVTCVLGRNGVGKTTLLKTLMGLLPVKSGSIRLDGEDITKLPPHERaRAGIAYVPQGREIFPRLTVEE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  100 NITVVprmLGWDKKRCHARAEELMsmvALDP--KRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPfgavdpinRE 177
Cdd:TIGR03410  95 NLLTG---LAALPRRSRKIPDEIY---ELFPvlKEMLGRRGGDLSGGQQQQLAIARALVTRPKLLLLDEP--------TE 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 727180512  178 TIQ-NEFLDMQRQLKK-------TVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADEL 228
Cdd:TIGR03410 161 GIQpSIIKDIGRVIRRlraeggmAILLVEQYLDFARELADRYYVMERGRVVASGAGDEL 219

PhnK

COG1101

ABC-type uncharacterized transport system, ATPase component [General function prediction only]; ...

1-227

2.07e-33

ABC-type uncharacterized transport system, ATPase component [General function prediction only];

Pssm-ID: 440718 [Multi-domain] Cd Length: 264 Bit Score: 125.20 E-value: 2.07e-33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqKNGTP--FNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSL 78
Cdd:COG1101    1 MLELKNLSKTF--NPGTVneKRALDGLNLTIEEGDFVTVIGSNGAGKSTLLNAIAGSLPPDSGSILIDGKDVTKLPEYKR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  79 RRKIGYVIQ--QIGLFPNMTIEENITVV-----PRMLGW--DKKRcHARAEELMSMVALD-PKRfLHRYPKEMSGGQQQR 148
Cdd:COG1101   79 AKYIGRVFQdpMMGTAPSMTIEENLALAyrrgkRRGLRRglTKKR-RELFRELLATLGLGlENR-LDTKVGLLSGGQRQA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 149 IGVIRALAADPPVLLMDEPFGAVDPINRETIqnefLDMQRQL----KKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNAS 224
Cdd:COG1101  157 LSLLMATLTKPKLLLLDEHTAALDPKTAALV----LELTEKIveenNLTTLMVTHNMEQALDYGNRLIMMHEGRIILDVS 232


                 ...
gi 727180512 225 ADE 227
Cdd:COG1101  233 GEE 235

nickel_nikE

TIGR02769

nickel import ATP-binding protein NikE; This family represents the NikE subunit of a ...

22-233

3.57e-33

nickel import ATP-binding protein NikE; This family represents the NikE subunit of a multisubunit nickel import ABC transporter complex. Nickel, once imported, may be used in urease and in certain classes of hydrogenase and superoxide dismutase. [Transport and binding proteins, Cations and iron carrying compounds]

Pssm-ID: 131816 [Multi-domain] Cd Length: 265 Bit Score: 124.53 E-value: 3.57e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   22 VDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVS---LRRKIGYVIQQ-IGLF-PNMT 96
Cdd:TIGR02769  27 LTNVSLSIEEGETVGLLGRSGCGKSTLARLLLGLEKPAQGTVSFRGQDLYQLDRKQrraFRRDVQLVFQDsPSAVnPRMT 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   97 IEENITVVPR-MLGWDKKRCHARAEELMSMVALDPKrFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPIN 175
Cdd:TIGR02769 107 VRQIIGEPLRhLTSLDESEQKARIAELLDMVGLRSE-DADKLPRQLSGGQLQRINIARALAVKPKLIVLDEAVSNLDMVL 185

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  176 RETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELL--ARPA 233
Cdd:TIGR02769 186 QAVILELLRKLQQAFGTAYLFITHDLRLVQSFCQRVAVMDKGQIVEECDVAQLLsfKHPA 245

cbiO

PRK13647

cobalt transporter ATP-binding subunit; Provisional

2-233

5.62e-33

cobalt transporter ATP-binding subunit; Provisional

Pssm-ID: 237457 [Multi-domain] Cd Length: 274 Bit Score: 124.08 E-value: 5.62e-33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTkqFMQKNGTpfNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRK 81
Cdd:PRK13647   5 IEVEDLH--FRYKDGT--KALKGLSLSIPEGSKTALLGPNGAGKSTLLLHLNGIYLPQRGRVKVMGREVNAENEKWVRSK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQ----QIglFpNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALdpKRFLHRYPKEMSGGQQQRIGVIRALAA 157
Cdd:PRK13647  81 VGLVFQdpddQV--F-SSTVWDDVAFGPVNMGLDKDEVERRVEEALKAVRM--WDFRDKPPYHLSYGQKKRVAIAGVLAM 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727180512 158 DPPVLLMDEPFGAVDPINRETIQnEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQnASADELLARPA 233
Cdd:PRK13647 156 DPDVIVLDEPMAYLDPRGQETLM-EILDRLHNQGKTVIVATHDVDLAAEWADQVIVLKEGRVLA-EGDKSLLTDED 229

ABCC_Hemolysin

cd03252

ATP-binding cassette domain of hemolysin B, subfamily C; The ABC-transporter hemolysin B is a ...

21-231

6.07e-33

ATP-binding cassette domain of hemolysin B, subfamily C; The ABC-transporter hemolysin B is a central component of the secretion machinery that translocates the toxin, hemolysin A, in a Sec-independent fashion across both membranes of E. coli. The hemolysin A (HlyA) transport machinery is composed of the ATP-binding cassette (ABC) transporter HlyB located in the inner membrane, hemolysin D (HlyD), also anchored in the inner membrane, and TolC, which resides in the outer membrane. HlyD apparently forms a continuous channel that bridges the entire periplasm, interacting with TolC and HlyB. This arrangement prevents the appearance of periplasmic intermediates of HlyA during substrate transport. Little is known about the molecular details of HlyA transport, but it is evident that ATP-hydrolysis by the ABC-transporter HlyB is a necessary source of energy.

Pssm-ID: 213219 [Multi-domain] Cd Length: 237 Bit Score: 122.98 E-value: 6.07e-33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  21 AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRKIGYVIQQIGLFpNMTIEEN 100
Cdd:cd03252   17 ILDNISLRIKPGEVVGIVGRSGSGKSTLTKLIQRFYVPENGRVLVDGHDLALADPAWLRRQVGVVLQENVLF-NRSIRDN 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 101 ITVVPRMLGWDKKRCHAR---AEELMSMVALDPKRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRE 177
Cdd:cd03252   96 IALADPGMSMERVIEAAKlagAHDFISELPEGYDTIVGEQGAGLSGGQRQRIAIARALIHNPRILIFDEATSALDYESEH 175

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 727180512 178 TIQNeflDMQRQLK-KTVMLVSHDIdEALKLGDRIAVFRQGKIVQNASADELLAR 231
Cdd:cd03252  176 AIMR---NMHDICAgRTVIIIAHRL-STVKNADRIIVMEKGRIVEQGSHDELLAE 226

ABC_NatA_like

cd03267

ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; ...

2-220

1.31e-32

ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; NatA is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled to proton or K+ uptake. NatB possess six putative membrane spanning regions at its C-terminus. In B. subtilis, NatAB is inducible by agents such as ethanol and protonophores, which lower the proton-motive force across the membrane. The closest sequence similarity to NatA is exhibited by DrrA of the two-component daunorubicin- and doxorubicin-efflux system. Hence, the functional NatAB is presumably assembled with two copies of the single ATP-binding protein and the single integral membrane protein.

Pssm-ID: 213234 [Multi-domain] Cd Length: 236 Bit Score: 122.06 E-value: 1.31e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFMQKNGTPF----------------NAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILI 65
Cdd:cd03267    1 IEVSNLSKSYRVYSKEPGligslkslfkrkyrevEALKGISFTIEKGEIVGFIGPNGAGKTTTLKILSGLLQPTSGEVRV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  66 NGEDTSAlDTVSLRRKIGYVI-QQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMvaLDPKRFLHRYPKEMSGG 144
Cdd:cd03267   81 AGLVPWK-RRKKFLRRIGVVFgQKTQLWWDLPVIDSFYLLAAIYDLPPARFKKRLDELSEL--LDLEELLDTPVRQLSLG 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727180512 145 QQQRIGVIRALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIV 220
Cdd:cd03267  158 QRMRAEIAAALLHEPEILFLDEPTIGLDVVAQENIRNFLKEYNRERGTTVLLTSHYMKDIEALARRVLVIDKGRLL 233

ABC_KpsT_Wzt

cd03220

ATP-binding cassette component of polysaccharide transport system; The KpsT/Wzt ABC ...

2-220

2.00e-32

ATP-binding cassette component of polysaccharide transport system; The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and teichoic acids have been shown to be exported by ABC transporters. A typical system is made of a conserved integral membrane and an ABC. In addition to these proteins, capsular polysaccharide exporter systems require two 'accessory' proteins to perform their function: a periplasmic (E.coli) or a lipid-anchored outer membrane protein called OMA (Neisseria meningitidis and Haemophilus influenza) and a cytoplasmic membrane protein MPA2.

Pssm-ID: 213187 [Multi-domain] Cd Length: 224 Bit Score: 121.49 E-value: 2.00e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQF-----------------MQKNGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTIL 64
Cdd:cd03220    1 IELENVSKSYptykggssslkklgilgRKGEVGEFWALKDVSFEVPRGERIGLIGRNGAGKSTLLRLLAGIYPPDSGTVT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  65 INGEDTSALDtvslrrkIGYviqqiGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALdpKRFLHRYPKEMSGG 144
Cdd:cd03220   81 VRGRVSSLLG-------LGG-----GFNPELTGRENIYLNGRLLGLSRKEIDEKIDEIIEFSEL--GDFIDLPVKTYSSG 146

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727180512 145 QQQRIGVIRALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQlKKTVMLVSHDIDEALKLGDRIAVFRQGKIV 220
Cdd:cd03220  147 MKARLAFAIATALEPDILLIDEVLAVGDAAFQEKCQRRLRELLKQ-GKTVILVSHDPSSIKRLCDRALVLEKGKIR 221

PRK13633

energy-coupling factor transporter ATPase;

1-228

2.19e-32

energy-coupling factor transporter ATPase;

Pssm-ID: 237453 [Multi-domain] Cd Length: 280 Bit Score: 122.89 E-value: 2.19e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQ-KNGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTV-SL 78
Cdd:PRK13633   4 MIKCKNVSYKYESnEESTEKLALDDVNLEVKKGEFLVILGRNGSGKSTIAKHMNALLIPSEGKVYVDGLDTSDEENLwDI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  79 RRKIGYVIQQiglfPNMTI-----EENITVVPRMLGWDKKRCHARAEELMSMVALDPKRflhRYPKEM-SGGQQQRIGVI 152
Cdd:PRK13633  84 RNKAGMVFQN----PDNQIvativEEDVAFGPENLGIPPEEIRERVDESLKKVGMYEYR---RHAPHLlSGGQKQRVAIA 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727180512 153 RALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKlGDRIAVFRQGKIVQNASADEL 228
Cdd:PRK13633 157 GILAMRPECIIFDEPTAMLDPSGRREVVNTIKELNKKYGITIILITHYMEEAVE-ADRIIVMDSGKVVMEGTPKEI 231

CydD

TIGR02857

thiol reductant ABC exporter, CydD subunit; The gene pair cydCD encodes an ABC-family ...

2-213

2.36e-32

thiol reductant ABC exporter, CydD subunit; The gene pair cydCD encodes an ABC-family transporter in which each gene contains an N-terminal membrane-spanning domain (pfam00664) and a C-terminal ATP-binding domain (pfam00005). In E. coli these genes were discovered as mutants which caused the terminal heme-copper oxidase complex cytochrome bd to fail to assemble. Recent work has shown that the transporter is involved in export of redox-active thiol compounds such as cysteine and glutathione. The linkage to assembly of the cytochrome bd complex is further supported by the conserved operon structure found outside the gammaproteobacteria (cydABCD) containing both the transporter and oxidase genes components. The genes used as the seed members for this model are all either found in the gammproteobacterial context or the CydABCD context. All members of this family scoring above trusted at the time of its creation were from genomes which encode a cytochrome bd complex. Unfortunately, the gene symbol nomenclature adopted based on this operon in B. subtilis assigns cydC to the third gene in the operon where this gene is actually homologous to the E. coli cydD gene. We have chosen to name all homologs in this family in accordance with the precedence of publication of the E. coli name, CydD

Pssm-ID: 274323 [Multi-domain] Cd Length: 529 Bit Score: 127.40 E-value: 2.36e-32

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512    2 IKLENLTkqFMQKNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRK 81
Cdd:TIGR02857 322 LEFSGVS--VAYPGRRP--ALRPVSFTVPPGERVALVGPSGAGKSTLLNLLLGFVDPTEGSIAVNGVPLADADADSWRDQ 397

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   82 IGYVIQQIGLFPNmTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPK---RFLHRYPKEMSGGQQQRIGVIRALAAD 158
Cdd:TIGR02857 398 IAWVPQHPFLFAG-TIAENIRLARPDASDAEIREALERAGLDEFVAALPQgldTPIGEGGAGLSGGQAQRLALARAFLRD 476

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 727180512  159 PPVLLMDEPFGAVDPinrETiQNEFLDMQRQLK--KTVMLVSHDiDEALKLGDRIAV 213
Cdd:TIGR02857 477 APLLLLDEPTAHLDA---ET-EAEVLEALRALAqgRTVLLVTHR-LALAALADRIVV 528

rim_protein

TIGR01257

retinal-specific rim ABC transporter; This model describes the photoreceptor protein (rim ...

4-219

3.02e-32

retinal-specific rim ABC transporter; This model describes the photoreceptor protein (rim protein) in eukaryotes. It is the member of ABC transporter superfamily. Rim protein is a membrane glycoprotein which is localized in the photoreceptor outer segment discs. Mutation/s in its genetic loci is implicated in the recessive Stargardt's disease. [Transport and binding proteins, Other]

Pssm-ID: 130324 [Multi-domain] Cd Length: 2272 Bit Score: 128.98 E-value: 3.02e-32

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512     4 LENLTKQFmQKNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDT-SALDTVslRRKI 82
Cdd:TIGR01257  931 VKNLVKIF-EPSGRP--AVDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGKDIeTNLDAV--RQSL 1005

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512    83 GYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIGVIRALAADPPVL 162
Cdd:TIGR01257 1006 GMCPQHNILFHHLTVAEHILFYAQLKGRSWEEAQLEMEAMLEDTGLHHKR--NEEAQDLSGGMQRKLSVAIAFVGDAKVV 1083

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 727180512   163 LMDEPFGAVDPINRETIQNefLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKI 219
Cdd:TIGR01257 1084 VLDEPTSGVDPYSRRSIWD--LLLKYRSGRTIIMSTHHMDEADLLGDRIAIISQGRL 1138

CeuD

COG4604

ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and ...

1-229

3.42e-32

ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism];

Pssm-ID: 443654 [Multi-domain] Cd Length: 252 Bit Score: 121.34 E-value: 3.42e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqkNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRR 80
Cdd:COG4604    1 MIEIKNVSKRY---GGKV--VLDDVSLTIPKGGITALIGPNGAGKSTLLSMISRLLPPDSGEVLVDGLDVATTPSRELAK 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQQIGLFPNMTIEEnitVV-----PRMLGWDKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIGVIRAL 155
Cdd:COG4604   76 RLAILRQENHINSRLTVRE---LVafgrfPYSKGRLTAEDREIIDEAIAYLDLEDLA--DRYLDELSGGQRQRAFIAMVL 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 156 AADPPVLLMDEPfgavdpINretiqNefLDMQ-------------RQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQN 222
Cdd:COG4604  151 AQDTDYVLLDEP------LN-----N--LDMKhsvqmmkllrrlaDELGKTVVIVLHDINFASCYADHIVAMKDGRVVAQ 217


                 ....*..
gi 727180512 223 ASADELL 229
Cdd:COG4604  218 GTPEEII 224

PRK10895

lipopolysaccharide ABC transporter ATP-binding protein; Provisional

5-230

4.09e-32

lipopolysaccharide ABC transporter ATP-binding protein; Provisional

Pssm-ID: 182817 [Multi-domain] Cd Length: 241 Bit Score: 121.15 E-value: 4.09e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   5 ENLTKQFMQKNgtpfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDT-VSLRRKIG 83
Cdd:PRK10895   7 KNLAKAYKGRR-----VVEDVSLTVNSGEIVGLLGPNGAGKTTTFYMVVGIVPRDAGNIIIDDEDISLLPLhARARRGIG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  84 YVIQQIGLFPNMTIEENITVVPRML-GWDKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIGVIRALAADPPVL 162
Cdd:PRK10895  82 YLPQEASIFRRLSVYDNLMAVLQIRdDLSAEQREDRANELMEEFHIEHLR--DSMGQSLSGGERRRVEIARALAANPKFI 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727180512 163 LMDEPFGAVDPINRETIQnEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLA 230
Cdd:PRK10895 160 LLDEPFAGVDPISVIDIK-RIIEHLRDSGLGVLITDHNVRETLAVCERAYIVSQGHLIAHGTPTEILQ 226

PRK15079

oligopeptide ABC transporter ATP-binding protein OppF; Provisional

11-232

4.38e-32

oligopeptide ABC transporter ATP-binding protein OppF; Provisional

Pssm-ID: 185037 [Multi-domain] Cd Length: 331 Bit Score: 123.28 E-value: 4.38e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  11 FMQKNGTpFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLR--RKigyVIQQ 88
Cdd:PRK15079  27 FWQPPKT-LKAVDGVTLRLYEGETLGVVGESGCGKSTFARAIIGLVKATDGEVAWLGKDLLGMKDDEWRavRS---DIQM 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  89 I------GLFPNMTIEENI-----TVVPRMlgwDKKRCHARAEELMSMVALDPKrFLHRYPKEMSGGQQQRIGVIRALAA 157
Cdd:PRK15079 103 IfqdplaSLNPRMTIGEIIaeplrTYHPKL---SRQEVKDRVKAMMLKVGLLPN-LINRYPHEFSGGQCQRIGIARALIL 178

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727180512 158 DPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARP 232
Cdd:PRK15079 179 EPKLIICDEPVSALDVSIQAQVVNLLQQLQREMGLSLIFIAHDLAVVKHISDRVLVMYLGHAVELGTYDEVYHNP 253

type_I_sec_HlyB

TIGR01846

type I secretion system ABC transporter, HlyB family; Type I protein secretion is a system in ...

2-234

5.37e-32

type I secretion system ABC transporter, HlyB family; Type I protein secretion is a system in some Gram-negative bacteria to export proteins (often proteases) across both inner and outer membranes to the extracellular medium. This is one of three proteins of the type I secretion apparatus. Targeted proteins are not cleaved at the N-terminus, but rather carry signals located toward the extreme C-terminus to direct type I secretion. [Protein fate, Protein and peptide secretion and trafficking]

Pssm-ID: 273831 [Multi-domain] Cd Length: 694 Bit Score: 127.55 E-value: 5.37e-32

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512    2 IKLENLTkqFMQKNGTPfNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRK 81
Cdd:TIGR01846 456 ITFENIR--FRYAPDSP-EVLSNLNLDIKPGEFIGIVGPSGSGKSTLTKLLQRLYTPQHGQVLVDGVDLAIADPAWLRRQ 532

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   82 IGYVIQQIGLFpNMTIEENITVVPRMLGWDKKRCHAR---AEELMSmvaldpkRFLHRYPKE-------MSGGQQQRIGV 151
Cdd:TIGR01846 533 MGVVLQENVLF-SRSIRDNIALCNPGAPFEHVIHAAKlagAHDFIS-------ELPQGYNTEvgekganLSGGQRQRIAI 604

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  152 IRALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRqlKKTVMLVSHDIDeALKLGDRIAVFRQGKIVQNASADELLAR 231
Cdd:TIGR01846 605 ARALVGNPRILIFDEATSALDYESEALIMRNMREICR--GRTVIIIAHRLS-TVRACDRIIVLEKGQIAESGRHEELLAL 681


                  ...
gi 727180512  232 PAN 234
Cdd:TIGR01846 682 QGL 684

ABC_Carb_Monos_II

cd03215

Second domain of the ATP-binding cassette component of monosaccharide transport system; This ...

21-219

6.75e-32

Second domain of the ATP-binding cassette component of monosaccharide transport system; This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (such as xylose, arabinose, and ribose), that cannot be broken down to simple sugars by hydrolysis. In members of Carb_Monos family the single hydrophobic gene product forms a homodimer, while the ABC protein represents a fusion of two nucleotide-binding domains. However, it is assumed that two copies of the ABC domains are present in the assembled transporter.

Pssm-ID: 213182 [Multi-domain] Cd Length: 182 Bit Score: 118.69 E-value: 6.75e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  21 AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDT-VSLRRKIGYVI---QQIGLFPNMT 96
Cdd:cd03215   15 AVRDVSFEVRAGEIVGIAGLVGNGQTELAEALFGLRPPASGEITLDGKPVTRRSPrDAIRAGIAYVPedrKREGLVLDLS 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  97 IEENITVvPRMLgwdkkrcharaeelmsmvaldpkrflhrypkemSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINR 176
Cdd:cd03215   95 VAENIAL-SSLL---------------------------------SGGNQQKVVLARWLARDPRVLILDEPTRGVDVGAK 140

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 727180512 177 ETIQNEFLDMQRQlKKTVMLVSHDIDEALKLGDRIAVFRQGKI 219
Cdd:cd03215  141 AEIYRLIRELADA-GKAVLLISSELDELLGLCDRILVMYEGRI 182

cbiO

PRK13631

cobalt transporter ATP-binding subunit; Provisional

1-233

8.53e-32

cobalt transporter ATP-binding subunit; Provisional

Pssm-ID: 237451 [Multi-domain] Cd Length: 320 Bit Score: 122.27 E-value: 8.53e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQKNGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILI----NGEDTSALDTV 76
Cdd:PRK13631  21 ILRVKNLYCVFDEKQENELVALNNISYTFEKNKIYFIIGNSGSGKSTLVTHFNGLIKSKYGTIQVgdiyIGDKKNNHELI 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  77 S------------LRRKIGYVIQ--QIGLFPNmTIEENITVVPRMLGWDKKRCHARAEELMSMVALDpKRFLHRYPKEMS 142
Cdd:PRK13631 101 TnpyskkiknfkeLRRRVSMVFQfpEYQLFKD-TIEKDIMFGPVALGVKKSEAKKLAKFYLNKMGLD-DSYLERSPFGLS 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 143 GGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQlKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQN 222
Cdd:PRK13631 179 GGQKRRVAIAGILAIQPEILIFDEPTAGLDPKGEHEMMQLILDAKAN-NKTVFVITHTMEHVLEVADEVIVMDKGKILKT 257

                        250
                 ....*....|.
gi 727180512 223 ASADELLARPA 233
Cdd:PRK13631 258 GTPYEIFTDQH 268

ABCC_ATM1_transporter

cd03253

ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; ATM1 is an ABC ...

23-231

1.14e-31

ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; ATM1 is an ABC transporter that is expressed in the mitochondria. Although the specific function of ATM1 is unknown, its disruption results in the accumulation of excess mitochondrial iron, loss of mitochondrial cytochromes, oxidative damage to mitochondrial DNA, and decreased levels of cytosolic heme proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213220 [Multi-domain] Cd Length: 236 Bit Score: 119.64 E-value: 1.14e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  23 DNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRKIGYVIQQIGLFpNMTIEENIT 102
Cdd:cd03253   18 KDVSFTIPAGKKVAIVGPSGSGKSTILRLLFRFYDVSSGSILIDGQDIREVTLDSLRRAIGVVPQDTVLF-NDTIGYNIR 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 103 VvprmlgwdkKRCHARAEELMSMV-ALDPKRFLHRYPK-----------EMSGGQQQRIGVIRALAADPPVLLMDEPFGA 170
Cdd:cd03253   97 Y---------GRPDATDEEVIEAAkAAQIHDKIMRFPDgydtivgerglKLSGGEKQRVAIARAILKNPPILLLDEATSA 167

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727180512 171 VDPINRETIQNEFLDMQRqlKKTVMLVSHDIDEALKlGDRIAVFRQGKIVQNASADELLAR 231
Cdd:cd03253  168 LDTHTEREIQAALRDVSK--GRTTIVIAHRLSTIVN-ADKIIVLKDGRIVERGTHEELLAK 225

PRK10261

glutathione transporter ATP-binding protein; Provisional

20-221

1.92e-31

glutathione transporter ATP-binding protein; Provisional

Pssm-ID: 182342 [Multi-domain] Cd Length: 623 Bit Score: 125.35 E-value: 1.92e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  20 NAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGE--DT-SALDTVSLRRKIGYVIQQ--IGLFPN 94
Cdd:PRK10261 338 HAVEKVSFDLWPGETLSLVGESGSGKSTTGRALLRLVESQGGEIIFNGQriDTlSPGKLQALRRDIQFIFQDpyASLDPR 417

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  95 MTIEENITVVPRMLGW-DKKRCHARAEELMSMVALDPKRFLhRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDP 173
Cdd:PRK10261 418 QTVGDSIMEPLRVHGLlPGKAAAARVAWLLERVGLLPEHAW-RYPHEFSGGQRQRICIARALALNPKVIIADEAVSALDV 496

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 727180512 174 INRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQ 221
Cdd:PRK10261 497 SIRGQIINLLLDLQRDFGIAYLFISHDMAVVERISHRVAVMYLGQIVE 544

COG4586

ABC-type uncharacterized transport system, ATPase component [General function prediction only]; ...

1-231

2.60e-31

ABC-type uncharacterized transport system, ATPase component [General function prediction only];

Pssm-ID: 443643 [Multi-domain] Cd Length: 323 Bit Score: 120.96 E-value: 2.60e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQKNGTP----------------FNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTIL 64
Cdd:COG4586    1 IIEVENLSKTYRVYEKEPglkgalkglfrreyreVEAVDDISFTIEPGEIVGFIGPNGAGKSTTIKMLTGILVPTSGEVR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  65 INGEDTSAlDTVSLRRKIGYVI---QQigLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPkrFLHRYPKEM 141
Cdd:COG4586   81 VLGYVPFK-RRKEFARRIGVVFgqrSQ--LWWDLPAIDSFRLLKAIYRIPDAEYKKRLDELVELLDLGE--LLDTPVRQL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 142 SGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRETIQnEFL-DMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIV 220
Cdd:COG4586  156 SLGQRMRCELAAALLHRPKILFLDEPTIGLDVVSKEAIR-EFLkEYNRERGTTILLTSHDMDDIEALCDRVIVIDHGRII 234

                        250
                 ....*....|.
gi 727180512 221 QNASADELLAR 231
Cdd:COG4586  235 YDGSLEELKER 245

PRK13657

glucan ABC transporter ATP-binding protein/ permease;

21-231

2.87e-31

glucan ABC transporter ATP-binding protein/ permease;

Pssm-ID: 184214 [Multi-domain] Cd Length: 588 Bit Score: 124.69 E-value: 2.87e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  21 AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRKIGYVIQQIGLFpNMTIEEN 100
Cdd:PRK13657 350 GVEDVSFEAKPGQTVAIVGPTGAGKSTLINLLQRVFDPQSGRILIDGTDIRTVTRASLRRNIAVVFQDAGLF-NRSIEDN 428

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 101 ITVvprmlgwdkKRCHARAEELMSMV----ALDpkrFLHRYPK-----------EMSGGQQQRIGVIRALAADPPVLLMD 165
Cdd:PRK13657 429 IRV---------GRPDATDEEMRAAAeraqAHD---FIERKPDgydtvvgergrQLSGGERQRLAIARALLKDPPILILD 496

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 727180512 166 EPFGAVDPINRETIQnEFLDMQRQlKKTVMLVSH---DIDEAlklgDRIAVFRQGKIVQNASADELLAR 231
Cdd:PRK13657 497 EATSALDVETEAKVK-AALDELMK-GRTTFIIAHrlsTVRNA----DRILVFDNGRVVESGSFDELVAR 559

cbiO

PRK13642

energy-coupling factor transporter ATPase;

1-230

6.98e-31

energy-coupling factor transporter ATPase;

Pssm-ID: 184202 [Multi-domain] Cd Length: 277 Bit Score: 118.66 E-value: 6.98e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTkqFMQKNGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRR 80
Cdd:PRK13642   4 ILEVENLV--FKYEKESDVNQLNGVSFSITKGEWVSIIGQNGSGKSTTARLIDGLFEEFEGKVKIDGELLTAENVWNLRR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQQI-GLFPNMTIEENITVVPRMLGWDKKRCHARAEElmSMVALDPKRFLHRYPKEMSGGQQQRIGVIRALAADP 159
Cdd:PRK13642  82 KIGMVFQNPdNQFVGATVEDDVAFGMENQGIPREEMIKRVDE--ALLAVNMLDFKTREPARLSGGQKQRVAVAGIIALRP 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727180512 160 PVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKlGDRIAVFRQGKIVQNASADELLA 230
Cdd:PRK13642 160 EIIILDESTSMLDPTGRQEIMRVIHEIKEKYQLTVLSITHDLDEAAS-SDRILVMKAGEIIKEAAPSELFA 229

PRK11831

phospholipid ABC transporter ATP-binding protein MlaF;

23-232

9.79e-31

phospholipid ABC transporter ATP-binding protein MlaF;

Pssm-ID: 236997 [Multi-domain] Cd Length: 269 Bit Score: 117.94 E-value: 9.79e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  23 DNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSL---RRKIGYVIQQIGLFPNMTIEE 99
Cdd:PRK11831  24 DNISLTVPRGKITAIMGPSGIGKTTLLRLIGGQIAPDHGEILFDGENIPAMSRSRLytvRKRMSMLFQSGALFTDMNVFD 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 100 NI-------TVVPRMLgwdkkrchARAEELMSMVALDPKRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVD 172
Cdd:PRK11831 104 NVayplrehTQLPAPL--------LHSTVMMKLEAVGLRGAAKLMPSELSGGMARRAALARAIALEPDLIMFDEPFVGQD 175

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 173 PINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARP 232
Cdd:PRK11831 176 PITMGVLVKLISELNSALGVTCVVVSHDVPEVLSIADHAYIVADKKIVAHGSAQALQANP 235

PRK13537

nodulation factor ABC transporter ATP-binding protein NodI;

2-276

1.04e-30

nodulation factor ABC transporter ATP-binding protein NodI;

Pssm-ID: 237420 [Multi-domain] Cd Length: 306 Bit Score: 119.14 E-value: 1.04e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFMQKNgtpfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSlRRK 81
Cdd:PRK13537   8 IDFRNVEKRYGDKL-----VVDGLSFHVQRGECFGLLGPNGAGKTTTLRMLLGLTHPDAGSISLCGEPVPSRARHA-RQR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIGVIRALAADPPV 161
Cdd:PRK13537  82 VGVVPQFDNLDPDFTVRENLLVFGRYFGLSAAAARALVPPLLEFAKLENKA--DAKVGELSGGMKRRLTLARALVNDPDV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 162 LLMDEPFGAVDPINRETIQnEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEFVASFV 241
Cdd:PRK13537 160 LVLDEPTTGLDPQARHLMW-ERLRSLLARGKTILLTTHFMEEAERLCDRLCVIEEGRKIAEGAPHALIESEIGCDVIEIY 238

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 727180512 242 GQD-RTLKRLL--LVQAGDVAGQQETVTVRRETPLVEA 276
Cdd:PRK13537 239 GPDpVALRDELapLAERTEISGETLFCYVRDPEPLHAR 276

PRK14258

phosphate ABC transporter ATP-binding protein; Provisional

2-242

1.53e-30

phosphate ABC transporter ATP-binding protein; Provisional

Pssm-ID: 184593 [Multi-domain] Cd Length: 261 Bit Score: 117.45 E-value: 1.53e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQF-MQKngtpfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTG-----GTILINGEDT--SAL 73
Cdd:PRK14258   8 IKVNNLSFYYdTQK------ILEGVSMEIYQSKVTAIIGPSGCGKSTFLKCLNRMNELESevrveGRVEFFNQNIyeRRV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  74 DTVSLRRKIGYVIQQIGLFPnMTIEENITVVPRMLGWDKK-------RCHARAEELMSMValdpKRFLHRYPKEMSGGQQ 146
Cdd:PRK14258  82 NLNRLRRQVSMVHPKPNLFP-MSVYDNVAYGVKIVGWRPKleiddivESALKDADLWDEI----KHKIHKSALDLSGGQQ 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 147 QRIGVIRALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVF-----RQGKIVQ 221
Cdd:PRK14258 157 QRLCIARALAVKPKVLLMDEPCFGLDPIASMKVESLIQSLRLRSELTMVIVSHNLHQVSRLSDFTAFFkgnenRIGQLVE 236

                        250       260
                 ....*....|....*....|....*
gi 727180512 222 NASADELLARPAN----EFVASFVG 242
Cdd:PRK14258 237 FGLTKKIFNSPHDsrtrEYVLSRLG 261

COG4559

ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism];

1-229

2.30e-30

ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism];

Pssm-ID: 443620 [Multi-domain] Cd Length: 258 Bit Score: 116.75 E-value: 2.30e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQKNgtpfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRR 80
Cdd:COG4559    1 MLEAENLSVRLGGRT-----LLDDVSLTLRPGELTAIIGPNGAGKSTLLKLLTGELTPSSGEVRLNGRPLAAWSPWELAR 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQQIGL-FPnMTIEEnitVVpRM----LGWDKKRCHARAEELMSMVALDPkrFLHRYPKEMSGGQQQRIGVIRAL 155
Cdd:COG4559   76 RRAVLPQHSSLaFP-FTVEE---VV-ALgrapHGSSAAQDRQIVREALALVGLAH--LAGRSYQTLSGGEQQRVQLARVL 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 156 A-------ADPPVLLMDEPFGAVDPINretiQNEFLDMQRQLKK---TVMLVSHDIDEALKLGDRIAVFRQGKIVQNASA 225
Cdd:COG4559  149 AqlwepvdGGPRWLFLDEPTSALDLAH----QHAVLRLARQLARrggGVVAVLHDLNLAAQYADRILLLHQGRLVAQGTP 224


                 ....
gi 727180512 226 DELL 229
Cdd:COG4559  225 EEVL 228

cbiO

PRK13635

energy-coupling factor ABC transporter ATP-binding protein;

21-231

2.33e-30

energy-coupling factor ABC transporter ATP-binding protein;

Pssm-ID: 184195 [Multi-domain] Cd Length: 279 Bit Score: 117.42 E-value: 2.33e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  21 AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSAlDTV-SLRRKIGYVIQ----QiglFPNM 95
Cdd:PRK13635  22 ALKDVSFSVYEGEWVAIVGHNGSGKSTLAKLLNGLLLPEAGTITVGGMVLSE-ETVwDVRRQVGMVFQnpdnQ---FVGA 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  96 TIEENITV------VPR--MLgwdkKRCHArAEELMSMVAldpkrFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEP 167
Cdd:PRK13635  98 TVQDDVAFglenigVPReeMV----ERVDQ-ALRQVGMED-----FLNREPHRLSGGQKQRVAIAGVLALQPDIIILDEA 167

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727180512 168 FGAVDPINREtiqnEFLDMQRQLKK----TVMLVSHDIDEALKlGDRIAVFRQGKIVQNASADELLAR 231
Cdd:PRK13635 168 TSMLDPRGRR----EVLETVRQLKEqkgiTVLSITHDLDEAAQ-ADRVIVMNKGEILEEGTPEEIFKS 230

PRK14271

phosphate ABC transporter ATP-binding protein; Provisional

6-249

2.90e-30

phosphate ABC transporter ATP-binding protein; Provisional

Pssm-ID: 172759 [Multi-domain] Cd Length: 276 Bit Score: 117.12 E-value: 2.90e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   6 NLTKQFMQKNgtpfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGG-----TILINGEDT-SALDTVSLR 79
Cdd:PRK14271  26 NLTLGFAGKT-----VLDQVSMGFPARAVTSLMGPTGSGKTTFLRTLNRMNDKVSGyrysgDVLLGGRSIfNYRDVLEFR 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  80 RKIGYVIQQIGLFPnMTIEENI-------TVVPRmlgwdkKRCHARAEELMSMVAL--DPKRFLHRYPKEMSGGQQQRIG 150
Cdd:PRK14271 101 RRVGMLFQRPNPFP-MSIMDNVlagvrahKLVPR------KEFRGVAQARLTEVGLwdAVKDRLSDSPFRLSGGQQQLLC 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 151 VIRALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLkkTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLA 230
Cdd:PRK14271 174 LARTLAVNPEVLLLDEPTSALDPTTTEKIEEFIRSLADRL--TVIIVTHNLAQAARISDRAALFFDGRLVEEGPTEQLFS 251

                        250       260
                 ....*....|....*....|...
gi 727180512 231 RPAN----EFVASFVGQDRTLKR 249
Cdd:PRK14271 252 SPKHaetaRYVAGLSGDVKDAKR 274

MsbA_rel

TIGR02204

ABC transporter, permease/ATP-binding protein; This protein is related to a Proteobacterial ...

21-230

7.31e-30

ABC transporter, permease/ATP-binding protein; This protein is related to a Proteobacterial ATP transporter that exports lipid A and to eukaryotic P-glycoproteins.

Pssm-ID: 131259 [Multi-domain] Cd Length: 576 Bit Score: 120.58 E-value: 7.31e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   21 AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRKIGYVIQQIGLFPNmTIEEN 100
Cdd:TIGR02204 355 ALDGLNLTVRPGETVALVGPSGAGKSTLFQLLLRFYDPQSGRILLDGVDLRQLDPAELRARMALVPQDPVLFAA-SVMEN 433

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  101 ITVvprmlgwdkKRCHARAEELM-SMVALDPKRFLHRYP-----------KEMSGGQQQRIGVIRALAADPPVLLMDEPF 168
Cdd:TIGR02204 434 IRY---------GRPDATDEEVEaAARAAHAHEFISALPegydtylgergVTLSGGQRQRIAIARAILKDAPILLLDEAT 504

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 727180512  169 GAVDPINRETIQnEFLD--MQrqlKKTVMLVSHDIDEALKlGDRIAVFRQGKIVQNASADELLA 230
Cdd:TIGR02204 505 SALDAESEQLVQ-QALEtlMK---GRTTLIIAHRLATVLK-ADRIVVMDQGRIVAQGTHAELIA 563

TagH

COG1134

ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate ...

1-231

8.00e-30

ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism];

Pssm-ID: 440749 [Multi-domain] Cd Length: 245 Bit Score: 114.79 E-value: 8.00e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQF-----------------MQKNGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTI 63
Cdd:COG1134    4 MIEVENVSKSYrlyhepsrslkelllrrRRTRREEFWALKDVSFEVERGESVGIIGRNGAGKSTLLKLIAGILEPTSGRV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  64 LINGEDTSALDTvslrrkigyviqQIGLFPNMTIEENITVVPRMLGWDKKRCHARAE------ELmsmvaldpKRFLH-- 135
Cdd:COG1134   84 EVNGRVSALLEL------------GAGFHPELTGRENIYLNGRLLGLSRKEIDEKFDeivefaEL--------GDFIDqp 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 136 --RYpkemSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQlKKTVMLVSHDIDEALKLGDRIAV 213
Cdd:COG1134  144 vkTY----SSGMRARLAFAVATAVDPDILLVDEVLAVGDAAFQKKCLARIRELRES-GRTVIFVSHSMGAVRRLCDRAIW 218

                        250
                 ....*....|....*...
gi 727180512 214 FRQGKIVQNASADELLAR 231
Cdd:COG1134  219 LEKGRLVMDGDPEEVIAA 236

ABCC_cytochrome_bd

cd03247

ATP-binding cassette domain of CydCD, subfamily C; The CYD subfamily implicated in cytochrome ...

2-220

9.06e-30

ATP-binding cassette domain of CydCD, subfamily C; The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd quinol oxidase and for periplasmic c-type cytochromes. CydCD were proposed to determine a heterooligomeric complex important for heme export into the periplasm or to be involved in the maintenance of the proper redox state of the periplasmic space. In Bacillus subtilis, the absence of CydCD does not affect the presence of halo-cytochrome c in the membrane and this observation suggests that CydCD proteins are not involved in the export of heme in this organism.

Pssm-ID: 213214 [Multi-domain] Cd Length: 178 Bit Score: 112.79 E-value: 9.06e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFMQKNGTpfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTvSLRRK 81
Cdd:cd03247    1 LSINNVSFSYPEQEQQ---VLKNLSLELKQGEKIALLGRSGSGKSTLLQLLTGDLKPQQGEITLDGVPVSDLEK-ALSSL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFpNMTIEENITvvprmlgwdkkrcharaeelmsmvaldpKRFlhrypkemSGGQQQRIGVIRALAADPPV 161
Cdd:cd03247   77 ISVLNQRPYLF-DTTLRNNLG----------------------------RRF--------SGGERQRLALARILLQDAPI 119

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 727180512 162 LLMDEPFGAVDPINRETIQNEFLDMQRQlkKTVMLVSHDIdEALKLGDRIAVFRQGKIV 220
Cdd:cd03247  120 VLLDEPTVGLDPITERQLLSLIFEVLKD--KTLIWITHHL-TGIEHMDKILFLENGKII 175

PRK09984

phosphonate ABC transporter ATP-binding protein;

1-228

3.15e-29

phosphonate ABC transporter ATP-binding protein;

Pssm-ID: 182182 [Multi-domain] Cd Length: 262 Bit Score: 113.95 E-value: 3.15e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQKNGtpFNAVDninLDVPEGEICVLLGPSGCGKTTTLKMINRLI----------EPTGGTILINGEdt 70
Cdd:PRK09984   4 IIRVEKLAKTFNQHQA--LHAVD---LNIHHGEMVALLGPSGSGKSTLLRHLSGLItgdksagshiELLGRTVQREGR-- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  71 SALDTVSLRRKIGYVIQQIGLFPNMTIEENITV-----VP---RMLGWDKKRCHARAEELMSMVALdpKRFLHRYPKEMS 142
Cdd:PRK09984  77 LARDIRKSRANTGYIFQQFNLVNRLSVLENVLIgalgsTPfwrTCFSWFTREQKQRALQALTRVGM--VHFAHQRVSTLS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 143 GGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQN 222
Cdd:PRK09984 155 GGQQQRVAIARALMQQAKVILADEPIASLDPESARIVMDTLRDINQNDGITVVVTLHQVDYALRYCERIVALRQGHVFYD 234


                 ....*.
gi 727180512 223 ASADEL 228
Cdd:PRK09984 235 GSSQQF 240

nikE

PRK10419

nickel ABC transporter ATP-binding protein NikE;

22-230

7.68e-29

nickel ABC transporter ATP-binding protein NikE;

Pssm-ID: 236689 [Multi-domain] Cd Length: 268 Bit Score: 112.86 E-value: 7.68e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  22 VDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTV---SLRRKIGYVIQQ-IGLF-PNMT 96
Cdd:PRK10419  28 LNNVSLSLKSGETVALLGRSGCGKSTLARLLVGLESPSQGNVSWRGEPLAKLNRAqrkAFRRDIQMVFQDsISAVnPRKT 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  97 IEENITVVPR-MLGWDKKRCHARAEELMSMVALDPKrFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPIN 175
Cdd:PRK10419 108 VREIIREPLRhLLSLDKAERLARASEMLRAVDLDDS-VLDKRPPQLSGGQLQRVCLARALAVEPKLLILDEAVSNLDLVL 186

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 727180512 176 RETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLA 230
Cdd:PRK10419 187 QAGVIRLLKKLQQQFGTACLFITHDLRLVERFCQRVMVMDNGQIVETQPVGDKLT 241

cbiO

PRK13643

energy-coupling factor transporter ATPase;

1-229

9.22e-29

energy-coupling factor transporter ATPase;

Pssm-ID: 184203 [Multi-domain] Cd Length: 288 Bit Score: 113.29 E-value: 9.22e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQKNGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTI----LINGEDTSALDTV 76
Cdd:PRK13643   1 MIKFEKVNYTYQPNSPFASRALFDIDLEVKKGSYTALIGHTGSGKSTLLQHLNGLLQPTEGKVtvgdIVVSSTSKQKEIK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  77 SLRRKIGYVIQ--QIGLFPNmTIEENITVVPRMLGWDKKRCHARAEELMSMVALDpKRFLHRYPKEMSGGQQQRIGVIRA 154
Cdd:PRK13643  81 PVRKKVGVVFQfpESQLFEE-TVLKDVAFGPQNFGIPKEKAEKIAAEKLEMVGLA-DEFWEKSPFELSGGQMRRVAIAGI 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727180512 155 LAADPPVLLMDEPFGAVDPINRETIQNEFLDMQrQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELL 229
Cdd:PRK13643 159 LAMEPEVLVLDEPTAGLDPKARIEMMQLFESIH-QSGQTVVLVTHLMDDVADYADYVYLLEKGHIISCGTPSDVF 232

PRK10575

Fe3+-hydroxamate ABC transporter ATP-binding protein FhuC;

25-229

1.37e-28

Fe3+-hydroxamate ABC transporter ATP-binding protein FhuC;

Pssm-ID: 182561 [Multi-domain] Cd Length: 265 Bit Score: 112.19 E-value: 1.37e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  25 INLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRKIGYVIQQIGLFPNMTIEEnITVV 104
Cdd:PRK10575  30 LSLTFPAGKVTGLIGHNGSGKSTLLKMLGRHQPPSEGEILLDAQPLESWSSKAFARKVAYLPQQLPAAEGMTVRE-LVAI 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 105 PR-----MLGWDKKRCHARAEELMSMVALDPkrFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRETI 179
Cdd:PRK10575 109 GRypwhgALGRFGAADREKVEEAISLVGLKP--LAHRLVDSLSGGERQRAWIAMLVAQDSRCLLLDEPTSALDIAHQVDV 186

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 727180512 180 QNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELL 229
Cdd:PRK10575 187 LALVHRLSQERGLTVIAVLHDINMAARYCDYLVALRGGEMIAQGTPAELM 236

bacteriocin_ABC

TIGR01193

ABC-type bacteriocin transporter; This model describes ABC-type bacteriocin transporter. The ...

20-239

1.52e-28

ABC-type bacteriocin transporter; This model describes ABC-type bacteriocin transporter. The amino terminal domain (pfam03412) processes the N-terminal leader peptide from the bacteriocin while C-terminal domains resemble ABC transporter membrane protein and ATP-binding cassette domain. In general, bacteriocins are agents which are responsible for killing or inhibiting the closely related species or even different strains of the same species. Bacteriocins are usually encoded by bacterial plasmids. Bacteriocins are named after the species and hence in literature one encounters various names e.g., leucocin from Leuconostic geldium; pedicocin from Pedicoccus acidilactici; sakacin from Lactobacillus sake etc. [Protein fate, Protein and peptide secretion and trafficking, Protein fate, Protein modification and repair, Transport and binding proteins, Other]

Pssm-ID: 130261 [Multi-domain] Cd Length: 708 Bit Score: 117.15 E-value: 1.52e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   20 NAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRKIGYVIQQIGLFPNmTIEE 99
Cdd:TIGR01193 488 NILSDISLTIKMNSKTTIVGMSGSGKSTLAKLLVGFFQARSGEILLNGFSLKDIDRHTLRQFINYLPQEPYIFSG-SILE 566

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  100 NItvvprMLGWDKKrchARAEELMSMVAL-----DPKRFLHRYPKEM-------SGGQQQRIGVIRALAADPPVLLMDEP 167
Cdd:TIGR01193 567 NL-----LLGAKEN---VSQDEIWAACEIaeikdDIENMPLGYQTELseegssiSGGQKQRIALARALLTDSKVLILDES 638

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727180512  168 FGAVDPINRETIQNEFLDMQrqlKKTVMLVSHDIDEAlKLGDRIAVFRQGKIVQNASADELLARpaNEFVAS 239
Cdd:TIGR01193 639 TSNLDTITEKKIVNNLLNLQ---DKTIIFVAHRLSVA-KQSDKIIVLDHGKIIEQGSHDELLDR--NGFYAS 704

ssuB

PRK11247

aliphatic sulfonates transport ATP-binding subunit; Provisional

4-232

1.59e-28

aliphatic sulfonates transport ATP-binding subunit; Provisional

Pssm-ID: 183055 [Multi-domain] Cd Length: 257 Bit Score: 111.69 E-value: 1.59e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   4 LENLTKQFMQKNgtpfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINgedTSALDTVslRRKIG 83
Cdd:PRK11247  15 LNAVSKRYGERT-----VLNQLDLHIPAGQFVAVVGRSGCGKSTLLRLLAGLETPSAGELLAG---TAPLAEA--REDTR 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  84 YVIQQIGLFPNMTIEENITvvprmLGWdKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIGVIRALAADPPVLL 163
Cdd:PRK11247  85 LMFQDARLLPWKKVIDNVG-----LGL-KGQWRDAALQALAAVGLADRA--NEWPAALSGGQKQRVALARALIHRPGLLL 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 727180512 164 MDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADelLARP 232
Cdd:PRK11247 157 LDEPLGALDALTRIEMQDLIESLWQQHGFTVLLVTHDVSEAVAMADRVLLIEEGKIGLDLTVD--LPRP 223

cbiO

PRK13650

energy-coupling factor transporter ATPase;

1-231

1.65e-28

energy-coupling factor transporter ATPase;

Pssm-ID: 184209 [Multi-domain] Cd Length: 279 Bit Score: 112.52 E-value: 1.65e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQKNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRR 80
Cdd:PRK13650   4 IIEVKNLTFKYKEDQEKY--TLNDVSFHVKQGEWLSIIGHNGSGKSTTVRLIDGLLEAESGQIIIDGDLLTEENVWDIRH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQQI-GLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALdpKRFLHRYPKEMSGGQQQRIGVIRALAADP 159
Cdd:PRK13650  82 KIGMVFQNPdNQFVGATVEDDVAFGLENKGIPHEEMKERVNEALELVGM--QDFKEREPARLSGGQKQRVAIAGAVAMRP 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727180512 160 PVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEaLKLGDRIAVFRQGKIVQNASADELLAR 231
Cdd:PRK13650 160 KIIILDEATSMLDPEGRLELIKTIKGIRDDYQMTVISITHDLDE-VALSDRVLVMKNGQVESTSTPRELFSR 230

cbiO

PRK13649

energy-coupling factor transporter ATPase;

2-220

2.34e-28

energy-coupling factor transporter ATPase;

Pssm-ID: 184208 [Multi-domain] Cd Length: 280 Bit Score: 112.15 E-value: 2.34e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTkqFMQKNGTPFN--AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSAL----DT 75
Cdd:PRK13649   3 INLQNVS--YTYQAGTPFEgrALFDVNLTIEDGSYTAFIGHTGSGKSTIMQLLNGLHVPTQGSVRVDDTLITSTsknkDI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  76 VSLRRKIGYVIQqiglFPNM-----TIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKRFlHRYPKEMSGGQQQRIG 150
Cdd:PRK13649  81 KQIRKKVGLVFQ----FPESqlfeeTVLKDVAFGPQNFGVSQEEAEALAREKLALVGISESLF-EKNPFELSGGQMRRVA 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727180512 151 VIRALAADPPVLLMDEPFGAVDPINREtiqnEFLDMQRQLKK---TVMLVSHDIDEALKLGDRIAVFRQGKIV 220
Cdd:PRK13649 156 IAGILAMEPKILVLDEPTAGLDPKGRK----ELMTLFKKLHQsgmTIVLVTHLMDDVANYADFVYVLEKGKLV 224

modC

PRK11144

molybdenum ABC transporter ATP-binding protein ModC;

24-220

2.51e-28

molybdenum ABC transporter ATP-binding protein ModC;

Pssm-ID: 182993 [Multi-domain] Cd Length: 352 Bit Score: 113.43 E-value: 2.51e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  24 NINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGE---DTSAldTVSL---RRKIGYVIQQIGLFPNMTI 97
Cdd:PRK11144  16 TVNLTLPAQGITAIFGRSGAGKTSLINAISGLTRPQKGRIVLNGRvlfDAEK--GICLppeKRRIGYVFQDARLFPHYKV 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  98 EENITvvprmLGWDKKRcHARAEELMSMVALDPkrFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVD-PINR 176
Cdd:PRK11144  94 RGNLR-----YGMAKSM-VAQFDKIVALLGIEP--LLDRYPGSLSGGEKQRVAIGRALLTAPELLLMDEPLASLDlPRKR 165

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 727180512 177 ETIQneFLD-MQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIV 220
Cdd:PRK11144 166 ELLP--YLErLAREINIPILYVSHSLDEILRLADRVVVLEQGKVK 208

cbiO

PRK13644

energy-coupling factor transporter ATPase;

1-233

3.49e-28

energy-coupling factor transporter ATPase;

Pssm-ID: 106587 [Multi-domain] Cd Length: 274 Bit Score: 111.23 E-value: 3.49e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqKNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTV-SLR 79
Cdd:PRK13644   1 MIRLENVSYSY--PDGTP--ALENINLVIKKGEYIGIIGKNGSGKSTLALHLNGLLRPQKGKVLVSGIDTGDFSKLqGIR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  80 RKIGYVIQQIGL-FPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIGVIRALAAD 158
Cdd:PRK13644  77 KLVGIVFQNPETqFVGRTVEEDLAFGPENLCLPPIEIRKRVDRALAEIGLEKYR--HRSPKTLSGGQGQCVALAGILTME 154

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727180512 159 PPVLLMDEPFGAVDPINRETIQNEFLDMQRQlKKTVMLVSHDIDEaLKLGDRIAVFRQGKIVQNASADELLARPA 233
Cdd:PRK13644 155 PECLIFDEVTSMLDPDSGIAVLERIKKLHEK-GKTIVYITHNLEE-LHDADRIIVMDRGKIVLEGEPENVLSDVS 227

dppF

PRK11308

dipeptide transporter ATP-binding subunit; Provisional

21-232

4.96e-28

dipeptide transporter ATP-binding subunit; Provisional

Pssm-ID: 236898 [Multi-domain] Cd Length: 327 Bit Score: 111.98 E-value: 4.96e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  21 AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINrLIE-PTGGTILINGEDTSALDTV---SLRRKIGYVIQQ--IGLFPN 94
Cdd:PRK11308  30 ALDGVSFTLERGKTLAVVGESGCGKSTLARLLT-MIEtPTGGELYYQGQDLLKADPEaqkLLRQKIQIVFQNpyGSLNPR 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  95 MTIE---ENITVVPRMLGWDKKRchARAEELMSMVALDPKrFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAV 171
Cdd:PRK11308 109 KKVGqilEEPLLINTSLSAAERR--EKALAMMAKVGLRPE-HYDRYPHMFSGGQRQRIAIARALMLDPDVVVADEPVSAL 185

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727180512 172 DPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARP 232
Cdd:PRK11308 186 DVSVQAQVLNLMMDLQQELGLSYVFISHDLSVVEHIADEVMVMYLGRCVEKGTKEQIFNNP 246

PRK09700

D-allose ABC transporter ATP-binding protein AlsA;

1-229

8.74e-28

D-allose ABC transporter ATP-binding protein AlsA;

Pssm-ID: 182036 [Multi-domain] Cd Length: 510 Bit Score: 114.11 E-value: 8.74e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqkngTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALD-TVSLR 79
Cdd:PRK09700   5 YISMAGIGKSF-----GPVHALKSVNLTVYPGEIHALLGENGAGKSTLMKVLSGIHEPTKGTITINNINYNKLDhKLAAQ 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  80 RKIGYVIQQIGLFPNMTIEENITV----VPRMLG-----WDKKRchARAEELMSMVALdpKRFLHRYPKEMSGGQQQRIG 150
Cdd:PRK09700  80 LGIGIIYQELSVIDELTVLENLYIgrhlTKKVCGvniidWREMR--VRAAMMLLRVGL--KVDLDEKVANLSISHKQMLE 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 151 VIRALAADPPVLLMDEPfgaVDPINRETIQNEFLDMqRQLK---KTVMLVSHDIDEALKLGDRIAVFRQG-----KIVQN 222
Cdd:PRK09700 156 IAKTLMLDAKVIIMDEP---TSSLTNKEVDYLFLIM-NQLRkegTAIVYISHKLAEIRRICDRYTVMKDGssvcsGMVSD 231


                 ....*..
gi 727180512 223 ASADELL 229
Cdd:PRK09700 232 VSNDDIV 238

btuD

PRK09536

corrinoid ABC transporter ATPase; Reviewed

1-219

1.07e-27

corrinoid ABC transporter ATPase; Reviewed

Pssm-ID: 236554 [Multi-domain] Cd Length: 402 Bit Score: 112.63 E-value: 1.07e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqkNGTPFnaVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRR 80
Cdd:PRK09536   3 MIDVSDLSVEF---GDTTV--LDGVDLSVREGSLVGLVGPNGAGKTTLLRAINGTLTPTAGTVLVAGDDVEALSARAASR 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQQIGLFPNMTIEENITV-----VPRMLGWDKKRCHArAEELMSMVALDpkRFLHRYPKEMSGGQQQRIGVIRAL 155
Cdd:PRK09536  78 RVASVPQDTSLSFEFDVRQVVEMgrtphRSRFDTWTETDRAA-VERAMERTGVA--QFADRPVTSLSGGERQRVLLARAL 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 727180512 156 AADPPVLLMDEPFGAVDpINRetiQNEFLDMQRQL---KKTVMLVSHDIDEALKLGDRIAVFRQGKI 219
Cdd:PRK09536 155 AQATPVLLLDEPTASLD-INH---QVRTLELVRRLvddGKTAVAAIHDLDLAARYCDELVLLADGRV 217

cbiO

PRK13639

cobalt transporter ATP-binding subunit; Provisional

21-232

1.34e-27

cobalt transporter ATP-binding subunit; Provisional

Pssm-ID: 184199 [Multi-domain] Cd Length: 275 Bit Score: 109.78 E-value: 1.34e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  21 AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGE----DTSALdtVSLRRKIGYVIQQIG--LFPN 94
Cdd:PRK13639  17 ALKGINFKAEKGEMVALLGPNGAGKSTLFLHFNGILKPTSGEVLIKGEpikyDKKSL--LEVRKTVGIVFQNPDdqLFAP 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  95 mTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPkrFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPI 174
Cdd:PRK13639  95 -TVEEDVAFGPLNLGLSKEEVEKRVKEALKAVGMEG--FENKPPHHLSGGQKKRVAIAGILAMKPEIIVLDEPTSGLDPM 171

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 727180512 175 NRETIQNEFLDMQRQlKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARP 232
Cdd:PRK13639 172 GASQIMKLLYDLNKE-GITIIISTHDVDLVPVYADKVYVMSDGKIIKEGTPKEVFSDI 228

NupO

COG3845

ABC-type guanosine uptake system NupNOPQ, ATPase component NupO [Nucleotide transport and ...

3-228

2.11e-27

ABC-type guanosine uptake system NupNOPQ, ATPase component NupO [Nucleotide transport and metabolism];

Pssm-ID: 443055 [Multi-domain] Cd Length: 504 Bit Score: 112.81 E-value: 2.11e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   3 KLENLTkqfmQKNGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRK- 81
Cdd:COG3845  259 EVENLS----VRDDRGVPALKDVSLEVRAGEILGIAGVAGNGQSELAEALAGLRPPASGSIRLDGEDITGLSPRERRRLg 334

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVI---QQIGLFPNMTIEENITV----VPRMLGW---DKKRCHARAEELMsmvaldpKRFLHRYP------KEMSGGQ 145
Cdd:COG3845  335 VAYIPedrLGRGLVPDMSVAENLILgryrRPPFSRGgflDRKAIRAFAEELI-------EEFDVRTPgpdtpaRSLSGGN 407

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 146 QQRIGVIRALAADPPVLLMDEPFGAVDPINRETIQNEFLDMqRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIV----- 220
Cdd:COG3845  408 QQKVILARELSRDPKLLIAAQPTRGLDVGAIEFIHQRLLEL-RDAGAAVLLISEDLDEILALSDRIAVMYEGRIVgevpa 486


                 ....*...
gi 727180512 221 QNASADEL 228
Cdd:COG3845  487 AEATREEI 494

PRK10247

putative ABC transporter ATP-binding protein YbbL; Provisional

13-203

2.94e-27

putative ABC transporter ATP-binding protein YbbL; Provisional

Pssm-ID: 182331 [Multi-domain] Cd Length: 225 Bit Score: 107.49 E-value: 2.94e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  13 QKNGTPFnaVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRKIGYVIQQIGLF 92
Cdd:PRK10247  16 LAGDAKI--LNNISFSLRAGEFKLITGPSGCGKSTLLKIVASLISPTSGTLLFEGEDISTLKPEIYRQQVSYCAQTPTLF 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  93 PNmTIEENItVVPRMLGWDKKRCHARAEELMSMvALdPKRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVD 172
Cdd:PRK10247  94 GD-TVYDNL-IFPWQIRNQQPDPAIFLDDLERF-AL-PDTILTKNIAELSGGEKQRISLIRNLQFMPKVLLLDEITSALD 169

                        170       180       190
                 ....*....|....*....|....*....|.
gi 727180512 173 PINRETIQNEFLDMQRQLKKTVMLVSHDIDE 203
Cdd:PRK10247 170 ESNKHNVNEIIHRYVREQNIAVLWVTHDKDE 200

cbiO

PRK13652

cobalt transporter ATP-binding subunit; Provisional

1-232

3.26e-27

cobalt transporter ATP-binding subunit; Provisional

Pssm-ID: 172200 [Multi-domain] Cd Length: 277 Bit Score: 108.74 E-value: 3.26e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMqkngTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRR 80
Cdd:PRK13652   3 LIETRDLCYSYS----GSKEALNNINFIAPRNSRIAVIGPNGAGKSTLFRHFNGILKPTSGSVLIRGEPITKENIREVRK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQ----QIGlfpNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDpkRFLHRYPKEMSGGQQQRIGVIRALA 156
Cdd:PRK13652  79 FVGLVFQnpddQIF---SPTVEQDIAFGPINLGLDEETVAHRVSSALHMLGLE--ELRDRVPHHLSGGEKKRVAIAGVIA 153

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727180512 157 ADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARP 232
Cdd:PRK13652 154 MEPQVLVLDEPTAGLDPQGVKELIDFLNDLPETYGMTVIFSTHQLDLVPEMADYIYVMDKGRIVAYGTVEEIFLQP 229

PRK10535

macrolide ABC transporter ATP-binding protein/permease MacB;

23-222

3.35e-27

macrolide ABC transporter ATP-binding protein/permease MacB;

Pssm-ID: 182528 [Multi-domain] Cd Length: 648 Bit Score: 113.28 E-value: 3.35e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  23 DNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDT---VSLRRK-IGYVIQQIGLFPNMTIE 98
Cdd:PRK10535  25 KGISLDIYAGEMVAIVGASGSGKSTLMNILGCLDKPTSGTYRVAGQDVATLDAdalAQLRREhFGFIFQRYHLLSHLTAA 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  99 ENITVVPRMLGWDKKRCHARAEELMSMVALDPKrfLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRET 178
Cdd:PRK10535 105 QNVEVPAVYAGLERKQRLLRAQELLQRLGLEDR--VEYQPSQLSGGQQQRVSIARALMNGGQVILADEPTGALDSHSGEE 182

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 727180512 179 IQNeFLDMQRQLKKTVMLVSHDIDEALKlGDRIAVFRQGKIVQN 222
Cdd:PRK10535 183 VMA-ILHQLRDRGHTVIIVTHDPQVAAQ-AERVIEIRDGEIVRN 224

cbiO

PRK13636

cobalt transporter ATP-binding subunit; Provisional

1-231

3.95e-27

cobalt transporter ATP-binding subunit; Provisional

Pssm-ID: 184196 [Multi-domain] Cd Length: 283 Bit Score: 108.78 E-value: 3.95e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqKNGTpfNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGE--DTSALDTVSL 78
Cdd:PRK13636   5 ILKVEELNYNY--SDGT--HALKGININIKKGEVTAILGGNGAGKSTLFQNLNGILKPSSGRILFDGKpiDYSRKGLMKL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  79 RRKIGYVIQQIG--LFpNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIGVIRALA 156
Cdd:PRK13636  81 RESVGMVFQDPDnqLF-SASVYQDVSFGAVNLKLPEDEVRKRVDNALKRTGIEHLK--DKPTHCLSFGQKKRVAIAGVLV 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727180512 157 ADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLAR 231
Cdd:PRK13636 158 MEPKVLVLDEPTAGLDPMGVSEIMKLLVEMQKELGLTIIIATHDIDIVPLYCDNVFVMKEGRVILQGNPKEVFAE 232

lolD

PRK11629

lipoprotein-releasing ABC transporter ATP-binding protein LolD;

6-216

5.35e-27

lipoprotein-releasing ABC transporter ATP-binding protein LolD;

Pssm-ID: 183244 [Multi-domain] Cd Length: 233 Bit Score: 107.21 E-value: 5.35e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   6 NLTKQFmQKNGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVS---LR-RK 81
Cdd:PRK11629  10 NLCKRY-QEGSVQTDVLHNVSFSIGEGEMMAIVGSSGSGKSTLLHLLGGLDTPTSGDVIFNGQPMSKLSSAAkaeLRnQK 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPNMTIEENITVvPRMLGWDK-KRCHARAEELMSMVALDpKRFLHRyPKEMSGGQQQRIGVIRALAADPP 160
Cdd:PRK11629  89 LGFIYQFHHLLPDFTALENVAM-PLLIGKKKpAEINSRALEMLAAVGLE-HRANHR-PSELSGGERQRVAIARALVNNPR 165

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 727180512 161 VLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDideaLKLGDRIAvfRQ 216
Cdd:PRK11629 166 LVLADEPTGNLDARNADSIFQLLGELNRLQGTAFLVVTHD----LQLAKRMS--RQ 215

CydC

TIGR02868

thiol reductant ABC exporter, CydC subunit; The gene pair cydCD encodes an ABC-family ...

21-200

7.57e-27

thiol reductant ABC exporter, CydC subunit; The gene pair cydCD encodes an ABC-family transporter in which each gene contains an N-terminal membrane-spanning domain (pfam00664) and a C-terminal ATP-binding domain (pfam00005). In E. coli these genes were discovered as mutants which caused the terminal heme-copper oxidase complex cytochrome bd to fail to assemble. Recent work has shown that the transporter is involved in export of redox-active thiol compounds such as cysteine and glutathione. The linkage to assembly of the cytochrome bd complex is further supported by the conserved operon structure found outside the gammaproteobacteria (cydABCD) containing both the transporter and oxidase genes components. The genes used as the seed members for this model are all either found in the gammproteobacterial context or the CydABCD context. All members of this family scoring above trusted at the time of its creation were from genomes which encode a cytochrome bd complex.

Pssm-ID: 274331 [Multi-domain] Cd Length: 530 Bit Score: 111.68 E-value: 7.57e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   21 AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRKIGYVIQQIGLFpNMTIEEN 100
Cdd:TIGR02868 350 VLDGVSLDLPPGERVAILGPSGSGKSTLLATLAGLLDPLQGEVTLDGVPVSSLDQDEVRRRVSVCAQDAHLF-DTTVREN 428

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  101 ItvvprMLGwdkkRCHARAEELMSMVAldpKRFLHRYPKEM---------------SGGQQQRIGVIRALAADPPVLLMD 165
Cdd:TIGR02868 429 L-----RLA----RPDATDEELWAALE---RVGLADWLRALpdgldtvlgeggarlSGGERQRLALARALLADAPILLLD 496

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 727180512  166 EPFGAVDPINRETIQNEFLDMQRQlkKTVMLVSHD 200
Cdd:TIGR02868 497 EPTEHLDAETADELLEDLLAALSG--RTVVLITHH 529

PRK11160

cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed

2-231

1.10e-26

cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed

Pssm-ID: 236865 [Multi-domain] Cd Length: 574 Bit Score: 111.46 E-value: 1.10e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFMQKngtPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRK 81
Cdd:PRK11160 339 LTLNNVSFTYPDQ---PQPVLKGLSLQIKAGEKVALLGRTGCGKSTLLQLLTRAWDPQQGEILLNGQPIADYSEAALRQA 415

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFpNMTIEENITvvprmLGWDKkrchARAEELMSM---VAL-----DPKR---FLHRYPKEMSGGQQQRIG 150
Cdd:PRK11160 416 ISVVSQRVHLF-SATLRDNLL-----LAAPN----ASDEALIEVlqqVGLeklleDDKGlnaWLGEGGRQLSGGEQRRLG 485

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 151 VIRALAADPPVLLMDEPFGAVDpinRETIQnEFLDMQRQL--KKTVMLVSHDIdEALKLGDRIAVFRQGKIVQNASADEL 228
Cdd:PRK11160 486 IARALLHDAPLLLLDEPTEGLD---AETER-QILELLAEHaqNKTVLMITHRL-TGLEQFDRICVMDNGQIIEQGTHQEL 560


                 ...
gi 727180512 229 LAR 231
Cdd:PRK11160 561 LAQ 563

3a01208

TIGR00958

Conjugate Transporter-2 (CT2) Family protein; [Transport and binding proteins, Other]

24-232

1.15e-26

Conjugate Transporter-2 (CT2) Family protein; [Transport and binding proteins, Other]

Pssm-ID: 273363 [Multi-domain] Cd Length: 711 Bit Score: 111.74 E-value: 1.15e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   24 NINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRKIGYVIQQIGLFpNMTIEENITV 103
Cdd:TIGR00958 499 GLTFTLHPGEVVALVGPSGSGKSTVAALLQNLYQPTGGQVLLDGVPLVQYDHHYLHRQVALVGQEPVLF-SGSVRENIAY 577

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  104 VPRMLGWDKKRCHARAEELMSMVALDPKRF---LHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRETIQ 180
Cdd:TIGR00958 578 GLTDTPDEEIMAAAKAANAHDFIMEFPNGYdteVGEKGSQLSGGQKQRIAIARALVRKPRVLILDEATSALDAECEQLLQ 657

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 727180512  181 NeflDMQRQlKKTVMLVSHDIDEALKlGDRIAVFRQGKIVQNASADELLARP 232
Cdd:TIGR00958 658 E---SRSRA-SRTVLLIAHRLSTVER-ADQILVLKKGSVVEMGTHKQLMEDQ 704

ArpD

COG4618

ABC-type protease/lipase transport system, ATPase and permease components [Intracellular ...

22-231

2.25e-26

ABC-type protease/lipase transport system, ATPase and permease components [Intracellular trafficking, secretion, and vesicular transport];

Pssm-ID: 443660 [Multi-domain] Cd Length: 563 Bit Score: 110.22 E-value: 2.25e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  22 VDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRKIGYVIQQIGLFPNmTIEENI 101
Cdd:COG4618  348 LRGVSFSLEPGEVLGVIGPSGSGKSTLARLLVGVWPPTAGSVRLDGADLSQWDREELGRHIGYLPQDVELFDG-TIAENI 426

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 102 TvvpRMLGWDKKRCH--ARAEELMSMVAldpkRFLHRYPKE-------MSGGQQQRIGVIRALAADPPVLLMDEPfgavd 172
Cdd:COG4618  427 A---RFGDADPEKVVaaAKLAGVHEMIL----RLPDGYDTRigeggarLSGGQRQRIGLARALYGDPRLVVLDEP----- 494

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727180512 173 pinretiqNEFLDMQ---------RQLKK---TVMLVSHDIdEALKLGDRIAVFRQGKIVQNASADELLAR 231
Cdd:COG4618  495 --------NSNLDDEgeaalaaaiRALKArgaTVVVITHRP-SLLAAVDKLLVLRDGRVQAFGPRDEVLAR 556

nikD

PRK10418

nickel transporter ATP-binding protein NikD; Provisional

2-253

1.02e-25

nickel transporter ATP-binding protein NikD; Provisional

Pssm-ID: 236688 [Multi-domain] Cd Length: 254 Bit Score: 104.01 E-value: 1.02e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQfmqkngTPFNAVDNINLDVPEGEICVLLGPSGCGKTTT----LKMINRLIEPTGGTILINGEDTSAldtVS 77
Cdd:PRK10418   5 IELRNIALQ------AAQPLVHGVSLTLQRGRVLALVGGSGSGKSLTcaaaLGILPAGVRQTAGRVLLDGKPVAP---CA 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  78 LR-RKIGYVIQ--QIGLFPNMTIEENITVVPRMLGwdKKRCHARAEELMSMVAL-DPKRFLHRYPKEMSGGQQQRIGVIR 153
Cdd:PRK10418  76 LRgRKIATIMQnpRSAFNPLHTMHTHARETCLALG--KPADDATLTAALEAVGLeNAARVLKLYPFEMSGGMLQRMMIAL 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 154 ALAADPPVLLMDEPFGAVDPInretIQNEFLDMQRQLKKT----VMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELL 229
Cdd:PRK10418 154 ALLCEAPFIIADEPTTDLDVV----AQARILDLLESIVQKralgMLLVTHDMGVVARLADDVAVMSHGRIVEQGDVETLF 229

                        250       260
                 ....*....|....*....|....
gi 727180512 230 ARPANEFVASFVGQDRTLKRLLLV 253
Cdd:PRK10418 230 NAPKHAVTRSLVSAHLALYGMELA 253

hmuV

PRK13548

hemin importer ATP-binding subunit; Provisional

1-229

1.03e-25

hemin importer ATP-binding subunit; Provisional

Pssm-ID: 237422 [Multi-domain] Cd Length: 258 Bit Score: 104.08 E-value: 1.03e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQKNgtpfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRR 80
Cdd:PRK13548   2 MLEARNLSVRLGGRT-----LLDDVSLTLRPGEVVAILGPNGAGKSTLLRALSGELSPDSGEVRLNGRPLADWSPAELAR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQQIGL-FPnMTIEEnitVVpRM----LGWDKKRCHARAEELMSMVALDPkrFLHRYPKEMSGGQQQRIGVIRAL 155
Cdd:PRK13548  77 RRAVLPQHSSLsFP-FTVEE---VV-AMgrapHGLSRAEDDALVAAALAQVDLAH--LAGRDYPQLSGGEQQRVQLARVL 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 156 A------ADPPVLLMDEPFGAVDPINRETIqnefLDMQRQLKK----TVMLVSHDIDEALKLGDRIAVFRQGKIVQNASA 225
Cdd:PRK13548 150 AqlwepdGPPRWLLLDEPTSALDLAHQHHV----LRLARQLAHerglAVIVVLHDLNLAARYADRIVLLHQGRLVADGTP 225


                 ....
gi 727180512 226 DELL 229
Cdd:PRK13548 226 AEVL 229

MglA

COG1129

ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism];

21-228

1.31e-25

ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism];

Pssm-ID: 440745 [Multi-domain] Cd Length: 497 Bit Score: 107.80 E-value: 1.31e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  21 AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTV-SLRRKIGYVI---QQIGLFPNMT 96
Cdd:COG1129  267 VVRDVSFSVRAGEILGIAGLVGAGRTELARALFGADPADSGEIRLDGKPVRIRSPRdAIRAGIAYVPedrKGEGLVLDLS 346

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  97 IEENIT--VVPRM--LGW-DKKRCHARAEELMSMVALDPKRfLHRYPKEMSGGQQQRIgVI-RALAADPPVLLMDEPF-- 168
Cdd:COG1129  347 IRENITlaSLDRLsrGGLlDRRRERALAEEYIKRLRIKTPS-PEQPVGNLSGGNQQKV-VLaKWLATDPKVLILDEPTrg 424

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727180512 169 ---GAvdpinretiQNEFLDMQRQLK---KTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADEL 228
Cdd:COG1129  425 idvGA---------KAEIYRLIRELAaegKAVIVISSELPELLGLSDRILVMREGRIVGELDREEA 481

PRK10908

cell division ATP-binding protein FtsE;

1-220

1.42e-25

cell division ATP-binding protein FtsE;

Pssm-ID: 182829 [Multi-domain] Cd Length: 222 Bit Score: 103.03 E-value: 1.42e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQKNgtpfNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVS--- 77
Cdd:PRK10908   1 MIRFEHVSKAYLGGR----QALQGVTFHMRPGEMAFLTGHSGAGKSTLLKLICGIERPSAGKIWFSGHDITRLKNREvpf 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  78 LRRKIGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIGVIRALAA 157
Cdd:PRK10908  77 LRRQIGMIFQDHHLLMDRTVYDNVAIPLIIAGASGDDIRRRVSAALDKVGLLDKA--KNFPIQLSGGEQQRVGIARAVVN 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727180512 158 DPPVLLMDEPFGAVDPINRETIQNEFLDMQRqLKKTVMLVSHDIDEALKLGDRIAVFRQGKIV 220
Cdd:PRK10908 155 KPAVLLADEPTGNLDDALSEGILRLFEEFNR-VGVTVLMATHDIGLISRRSYRMLTLSDGHLH 216

AztA

NF040873

zinc ABC transporter ATP-binding protein AztA;

21-205

1.53e-25

zinc ABC transporter ATP-binding protein AztA;

Pssm-ID: 468810 [Multi-domain] Cd Length: 191 Bit Score: 101.93 E-value: 1.53e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  21 AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTIlingedtsaldTVSLRRKIGYVIQQIGL---FPnMTI 97
Cdd:NF040873   7 VLHGVDLTIPAGSLTAVVGPNGSGKSTLLKVLAGVLRPTSGTV-----------RRAGGARVAYVPQRSEVpdsLP-LTV 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  98 EENITV--VPRMLGWDKKRCHARAEELMSMVALDPKRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPIN 175
Cdd:NF040873  75 RDLVAMgrWARRGLWRRLTRDDRAAVDDALERVGLADLAGRQLGELSGGQRQRALLAQGLAQEADLLLLDEPTTGLDAES 154

                        170       180       190
                 ....*....|....*....|....*....|
gi 727180512 176 RETIqNEFLDMQRQLKKTVMLVSHDIDEAL 205
Cdd:NF040873 155 RERI-IALLAEEHARGATVVVVTHDLELVR 183

livF

PRK11614

high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF;

1-233

2.36e-25

high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF;

Pssm-ID: 183231 [Multi-domain] Cd Length: 237 Bit Score: 102.65 E-value: 2.36e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQkngtpFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVS-LR 79
Cdd:PRK11614   5 MLSFDKVSAHYGK-----IQALHEVSLHINQGEIVTLIGANGAGKTTLLGTLCGDPRATSGRIVFDGKDITDWQTAKiMR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  80 RKIGYVIQQIGLFPNMTIEENITvvprMLGW--DKKRCHARAEELMsmvALDPKRFLHRYPKE--MSGGQQQRIGVIRAL 155
Cdd:PRK11614  80 EAVAIVPEGRRVFSRMTVEENLA----MGGFfaERDQFQERIKWVY---ELFPRLHERRIQRAgtMSGGEQQMLAIGRAL 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 156 AADPPVLLMDEPFGAVDPInretIQNEFLDMQRQLKK---TVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARP 232
Cdd:PRK11614 153 MSQPRLLLLDEPSLGLAPI----IIQQIFDTIEQLREqgmTIFLVEQNANQALKLADRGYVLENGHVVLEDTGDALLANE 228


                 .
gi 727180512 233 A 233
Cdd:PRK11614 229 A 229

livG

PRK11300

leucine/isoleucine/valine transporter ATP-binding subunit; Provisional

21-228

3.35e-25

leucine/isoleucine/valine transporter ATP-binding subunit; Provisional

Pssm-ID: 183080 [Multi-domain] Cd Length: 255 Bit Score: 102.76 E-value: 3.35e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  21 AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRKiGYV--IQQIGLFPNMTIE 98
Cdd:PRK11300  20 AVNNVNLEVREQEIVSLIGPNGAGKTTVFNCLTGFYKPTGGTILLRGQHIEGLPGHQIARM-GVVrtFQHVRLFREMTVI 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  99 ENITVVP-RML------GWDKKRCHARAE-ELMSMVA--LDP---KRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMD 165
Cdd:PRK11300  99 ENLLVAQhQQLktglfsGLLKTPAFRRAEsEALDRAAtwLERvglLEHANRQAGNLAYGQQRRLEIARCMVTQPEILMLD 178

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727180512 166 EPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADEL 228
Cdd:PRK11300 179 EPAAGLNPKETKELDELIAELRNEHNVTVLLIEHDMKLVMGISDRIYVVNQGTPLANGTPEEI 241

type_I_sec_PrtD

TIGR01842

type I secretion system ABC transporter, PrtD family; Type I protein secretion is a system in ...

22-230

5.07e-25

type I secretion system ABC transporter, PrtD family; Type I protein secretion is a system in some Gram-negative bacteria to export proteins (often proteases) across both inner and outer membranes to the extracellular medium. This is one of three proteins of the type I secretion apparatus. Targeted proteins are not cleaved at the N-terminus, but rather carry signals located toward the extreme C-terminus to direct type I secretion. [Protein fate, Protein and peptide secretion and trafficking]

Pssm-ID: 200134 [Multi-domain] Cd Length: 544 Bit Score: 106.28 E-value: 5.07e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   22 VDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRKIGYVIQQIGLFPNmTIEENI 101
Cdd:TIGR01842 334 LRGISFSLQAGEALAIIGPSGSGKSTLARLIVGIWPPTSGSVRLDGADLKQWDRETFGKHIGYLPQDVELFPG-TVAENI 412

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  102 TVVPRMLGWDKKRCHARAEELMSMVAldpkRFLHRYPKE-------MSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPI 174
Cdd:TIGR01842 413 ARFGENADPEKIIEAAKLAGVHELIL----RLPDGYDTVigpggatLSGGQRQRIALARALYGDPKLVVLDEPNSNLDEE 488

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 727180512  175 NRETIQNEFLDMQRQlKKTVMLVSHDIdEALKLGDRIAVFRQGKIVQNASADELLA 230
Cdd:TIGR01842 489 GEQALANAIKALKAR-GITVVVITHRP-SLLGCVDKILVLQDGRIARFGERDEVLA 542

PRK11176

lipid A ABC transporter ATP-binding protein/permease MsbA;

2-231

6.72e-25

lipid A ABC transporter ATP-binding protein/permease MsbA;

Pssm-ID: 183016 [Multi-domain] Cd Length: 582 Bit Score: 106.26 E-value: 6.72e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFMQKNgTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRK 81
Cdd:PRK11176 342 IEFRNVTFTYPGKE-VP--ALRNINFKIPAGKTVALVGRSGSGKSTIANLLTRFYDIDEGEILLDGHDLRDYTLASLRNQ 418

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFpNMTIEENITvvprmlgWDKKRCHARA--EELMSMV-ALDpkrFLHRYPK-----------EMSGGQQQ 147
Cdd:PRK11176 419 VALVSQNVHLF-NDTIANNIA-------YARTEQYSREqiEEAARMAyAMD---FINKMDNgldtvigengvLLSGGQRQ 487

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 148 RIGVIRALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQlkKTVMLVSH---DIDEAlklgDRIAVFRQGKIVQNAS 224
Cdd:PRK11176 488 RIAIARALLRDSPILILDEATSALDTESERAIQAALDELQKN--RTSLVIAHrlsTIEKA----DEILVVEDGEIVERGT 561


                 ....*..
gi 727180512 225 ADELLAR 231
Cdd:PRK11176 562 HAELLAQ 568

PRK13536

nodulation factor ABC transporter ATP-binding protein NodI;

2-229

9.27e-25

nodulation factor ABC transporter ATP-binding protein NodI;

Pssm-ID: 237419 [Multi-domain] Cd Length: 340 Bit Score: 103.37 E-value: 9.27e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFMQKNgtpfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSlRRK 81
Cdd:PRK13536  42 IDLAGVSKSYGDKA-----VVNGLSFTVASGECFGLLGPNGAGKSTIARMILGMTSPDAGKITVLGVPVPARARLA-RAR 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKrfLHRYPKEMSGGQQQRIGVIRALAADPPV 161
Cdd:PRK13536 116 IGVVPQFDNLDLEFTVRENLLVFGRYFGMSTREIEAVIPSLLEFARLESK--ADARVSDLSGGMKRRLTLARALINDPQL 193

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727180512 162 LLMDEPFGAVDPINRETIQnEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELL 229
Cdd:PRK13536 194 LILDEPTTGLDPHARHLIW-ERLRSLLARGKTILLTTHFMEEAERLCDRLCVLEAGRKIAEGRPHALI 260

ABCC_MRP_domain1

cd03250

ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This ...

2-218

3.12e-24

ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This subfamily is also known as MRP (multidrug resistance-associated protein). Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resisting lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions, such as glutathione, glucuronate, and sulfate.

Pssm-ID: 213217 [Multi-domain] Cd Length: 204 Bit Score: 98.70 E-value: 3.12e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFMQKNGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGedtsaldtvslrrK 81
Cdd:cd03250    1 ISVEDASFTWDSGEQETSFTLKDINLEVPKGELVAIVGPVGSGKSSLLSALLGELEKLSGSVSVPG-------------S 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFpNMTIEENITvvprmlgWDKKRCHARAEELMSMVALDPKrfLHRYPK-------E----MSGGQQQRIG 150
Cdd:cd03250   68 IAYVSQEPWIQ-NGTIRENIL-------FGKPFDEERYEKVIKACALEPD--LEILPDgdlteigEkginLSGGQKQRIS 137

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727180512 151 VIRALAADPPVLLMDEPFGAVDP-----INRETIQNEFLDmqrqlKKTVMLVSHDIdEALKLGDRIAVFRQGK 218
Cdd:cd03250  138 LARAVYSDADIYLLDDPLSAVDAhvgrhIFENCILGLLLN-----NKTRILVTHQL-QLLPHADQIVVLDNGR 204

dppD

PRK11022

dipeptide transporter ATP-binding subunit; Provisional

1-232

5.63e-24

dipeptide transporter ATP-binding subunit; Provisional

Pssm-ID: 182906 [Multi-domain] Cd Length: 326 Bit Score: 100.97 E-value: 5.63e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQKnGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTG----GTILINGEDTSALDTV 76
Cdd:PRK11022   3 LLNVDKLSVHFGDE-SAPFRAVDRISYSVKQGEVVGIVGESGSGKSVSSLAIMGLIDYPGrvmaEKLEFNGQDLQRISEK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  77 SLRRKIGYVIQQIGLFPNMTIEENITVVPRML-------GWDKKRCHARAEELMSMVAL-DPKRFLHRYPKEMSGGQQQR 148
Cdd:PRK11022  82 ERRNLVGAEVAMIFQDPMTSLNPCYTVGFQIMeaikvhqGGNKKTRRQRAIDLLNQVGIpDPASRLDVYPHQLSGGMSQR 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 149 IGVIRALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADEL 228
Cdd:PRK11022 162 VMIAMAIACRPKLLIADEPTTALDVTIQAQIIELLLELQQKENMALVLITHDLALVAEAAHKIIVMYAGQVVETGKAHDI 241


                 ....
gi 727180512 229 LARP 232
Cdd:PRK11022 242 FRAP 245

ATM1

COG5265

ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components ...

23-231

9.92e-24

ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 444078 [Multi-domain] Cd Length: 605 Bit Score: 102.59 E-value: 9.92e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  23 DNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRKIGYVIQQIGLFpNMTIEENIT 102
Cdd:COG5265  375 KGVSFEVPAGKTVAIVGPSGAGKSTLARLLFRFYDVTSGRILIDGQDIRDVTQASLRAAIGIVPQDTVLF-NDTIAYNIA 453

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 103 vvprmLGwdkkRCHARAEELMS---MVALDPkrFLHRYPK-----------EMSGGQQQRIGVIRALAADPPVLLMDEPF 168
Cdd:COG5265  454 -----YG----RPDASEEEVEAaarAAQIHD--FIESLPDgydtrvgerglKLSGGEKQRVAIARTLLKNPPILIFDEAT 522

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727180512 169 GAVDPINRETIQNEFLDMQRQlkKTVMLVSH---DIDEAlklgDRIAVFRQGKIVQNASADELLAR 231
Cdd:COG5265  523 SALDSRTERAIQAALREVARG--RTTLVIAHrlsTIVDA----DEILVLEAGRIVERGTHAELLAQ 582

PRK15093

peptide ABC transporter ATP-binding protein SapD;

1-232

1.34e-23

peptide ABC transporter ATP-binding protein SapD;

Pssm-ID: 185049 [Multi-domain] Cd Length: 330 Bit Score: 99.88 E-value: 1.34e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQKNGtPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMI----NRLIEPTGGTILINGEDTSALDTV 76
Cdd:PRK15093   3 LLDIRNLTIEFKTSDG-WVKAVDRVSMTLTEGEIRGLVGESGSGKSLIAKAIcgvtKDNWRVTADRMRFDDIDLLRLSPR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  77 SLRRKIGYVIQQI------GLFPNMTIEEN-ITVVP---------RMLGWDKKrchaRAEELMSMVAL-DPKRFLHRYPK 139
Cdd:PRK15093  82 ERRKLVGHNVSMIfqepqsCLDPSERVGRQlMQNIPgwtykgrwwQRFGWRKR----RAIELLHRVGIkDHKDAMRSFPY 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 140 EMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKI 219
Cdd:PRK15093 158 ELTEGECQKVMIAIALANQPRLLIADEPTNAMEPTTQAQIFRLLTRLNQNNNTTILLISHDLQMLSQWADKINVLYCGQT 237

                        250
                 ....*....|...
gi 727180512 220 VQNASADELLARP 232
Cdd:PRK15093 238 VETAPSKELVTTP 250

SapD

COG4170

ABC-type antimicrobial peptide export system, ATPase component SapD [Defense mechanisms];

6-232

3.44e-23

ABC-type antimicrobial peptide export system, ATPase component SapD [Defense mechanisms];

Pssm-ID: 443330 [Multi-domain] Cd Length: 331 Bit Score: 98.82 E-value: 3.44e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   6 NLTKQFMQKNGtPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEP----TGGTILINGEDTSALdTVSLRRK 81
Cdd:COG4170    8 NLTIEIDTPQG-RVKAVDRVSLTLNEGEIRGLVGESGSGKSLIAKAICGITKDnwhvTADRFRWNGIDLLKL-SPRERRK 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 -----IGYVIQ--QIGLFPNMTIEENIT-VVP---------RMLGWDKKrchaRAEELMSMVAL-DPKRFLHRYPKEMSG 143
Cdd:COG4170   86 iigreIAMIFQepSSCLDPSAKIGDQLIeAIPswtfkgkwwQRFKWRKK----RAIELLHRVGIkDHKDIMNSYPHELTE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 144 GQQQRIGVIRALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNA 223
Cdd:COG4170  162 GECQKVMIAMAIANQPRLLIADEPTNAMESTTQAQIFRLLARLNQLQGTSILLISHDLESISQWADTITVLYCGQTVESG 241


                 ....*....
gi 727180512 224 SADELLARP 232
Cdd:COG4170  242 PTEQILKSP 250

PRK15134

microcin C ABC transporter ATP-binding protein YejF; Provisional

21-236

4.20e-23

microcin C ABC transporter ATP-binding protein YejF; Provisional

Pssm-ID: 237917 [Multi-domain] Cd Length: 529 Bit Score: 100.55 E-value: 4.20e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  21 AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIePTGGTILINGEDTSALD---TVSLRRKIGYVIQ--QIGLFPNM 95
Cdd:PRK15134 301 VVKNISFTLRPGETLGLVGESGSGKSTTGLALLRLI-NSQGEIWFDGQPLHNLNrrqLLPVRHRIQVVFQdpNSSLNPRL 379

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  96 T----IEENITVVPRMLgwDKKRCHARAEELMSMVALDPKRfLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAV 171
Cdd:PRK15134 380 NvlqiIEEGLRVHQPTL--SAAQREQQVIAVMEEVGLDPET-RHRYPAEFSGGQRQRIAIARALILKPSLIILDEPTSSL 456

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 727180512 172 DpinrETIQNEFLDMQRQLKKTVML----VSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPANEF 236
Cdd:PRK15134 457 D----KTVQAQILALLKSLQQKHQLaylfISHDLHVVRALCHQVIVLRQGEVVEQGDCERVFAAPQQEY 521

NHLM_micro_ABC1

TIGR03796

NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; This protein describes ...

22-232

5.10e-23

NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; This protein describes a multidomain ABC transporter subunit that is one of three protein families associated with some regularity with a distinctive family of putative bacteriocins. It includes a bacteriocin-processing peptidase domain at the N-terminus. Model TIGR03793 describes a conserved propeptide region for this bacteriocin family, unusual because it shows obvious homology a region of the enzyme nitrile hydratase up to the classic Gly-Gly cleavage motif. This family is therefore predicted to be a subunit of a bacteriocin processing and export system characteristic to this system that we designate NHLM, Nitrile Hydratase Leader Microcin. [Transport and binding proteins, Amino acids, peptides and amines, Cellular processes, Biosynthesis of natural products]

Pssm-ID: 274788 [Multi-domain] Cd Length: 710 Bit Score: 100.79 E-value: 5.10e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   22 VDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRKIGYVIQQIGLFPNmTIEENI 101
Cdd:TIGR03796 495 IENFSLTLQPGQRVALVGGSGSGKSTIAKLVAGLYQPWSGEILFDGIPREEIPREVLANSVAMVDQDIFLFEG-TVRDNL 573

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  102 TV----VP--RMLGWDKKRC-H----ARAEELMSMVALDPKRFlhrypkemSGGQQQRIGVIRALAADPPVLLMDEPFGA 170
Cdd:TIGR03796 574 TLwdptIPdaDLVRACKDAAiHdvitSRPGGYDAELAEGGANL--------SGGQRQRLEIARALVRNPSILILDEATSA 645

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727180512  171 VDPINRETIqnefLDMQRQLKKTVMLVSH------DIDEalklgdrIAVFRQGKIVQNASADELLARP 232
Cdd:TIGR03796 646 LDPETEKII----DDNLRRRGCTCIIVAHrlstirDCDE-------IIVLERGKVVQRGTHEELWAVG 702

met_CoM_red_A2

TIGR03269

methyl coenzyme M reductase system, component A2; The enzyme that catalyzes the final step in ...

2-231

6.36e-23

Pssm-ID: 132313 [Multi-domain] Cd Length: 520 Bit Score: 99.88 E-value: 6.36e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512    2 IKLENLTKQFmqkngTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRL--IEPTGGTILIN------------- 66
Cdd:TIGR03269   1 IEVKNLTKKF-----DGKEVLKNISFTIEEGEVLGILGRSGAGKSVLMHVLRGMdqYEPTSGRIIYHvalcekcgyverp 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   67 ---GE-----------------DTSALDTVSLRRKIGYVIQQ-IGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSM 125
Cdd:TIGR03269  76 skvGEpcpvcggtlepeevdfwNLSDKLRRRIRKRIAIMLQRtFALYGDDTVLDNVLEALEEIGYEGKEAVGRAVDLIEM 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  126 VALDpKRFLHrYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEAL 205
Cdd:TIGR03269 156 VQLS-HRITH-IARDLSGGEKQRVVLARQLAKEPFLFLADEPTGTLDPQTAKLVHNALEEAVKASGISMVLTSHWPEVIE 233

                         250       260
                  ....*....|....*....|....*.
gi 727180512  206 KLGDRIAVFRQGKIVQNASADELLAR 231
Cdd:TIGR03269 234 DLSDKAIWLENGEIKEEGTPDEVVAV 259

phnK

PRK11701

phosphonate C-P lyase system protein PhnK; Provisional

5-232

6.39e-23

phosphonate C-P lyase system protein PhnK; Provisional

Pssm-ID: 183280 [Multi-domain] Cd Length: 258 Bit Score: 96.53 E-value: 6.39e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   5 ENLTKQFmqkngTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSL----RR 80
Cdd:PRK11701  10 RGLTKLY-----GPRKGCRDVSFDLYPGEVLGIVGESGSGKTTLLNALSARLAPDAGEVHYRMRDGQLRDLYALseaeRR 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KI-----GYVIQQI--GLFPNMTIEENITVVPRMLGWDK-KRCHARAEELMSMVALDPKRfLHRYPKEMSGGQQQRIGVI 152
Cdd:PRK11701  85 RLlrtewGFVHQHPrdGLRMQVSAGGNIGERLMAVGARHyGDIRATAGDWLERVEIDAAR-IDDLPTTFSGGMQQRLQIA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 153 RALAADPPVLLMDEPFGAVDPinreTIQNEFLDMQRQLKKT----VMLVSHDIDEALKLGDRIAVFRQGKIVQNASADEL 228
Cdd:PRK11701 164 RNLVTHPRLVFMDEPTGGLDV----SVQARLLDLLRGLVRElglaVVIVTHDLAVARLLAHRLLVMKQGRVVESGLTDQV 239


                 ....
gi 727180512 229 LARP 232
Cdd:PRK11701 240 LDDP 243

PRK11174

cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed

22-228

7.99e-23

cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed

Pssm-ID: 236870 [Multi-domain] Cd Length: 588 Bit Score: 99.92 E-value: 7.99e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  22 VDNINLDVPEGEICVLLGPSGCGKTTtlkMINRLIE--PTGGTILINGEDTSALDTVSLRRKIGYVIQQIGLFPNmTIEE 99
Cdd:PRK11174 366 AGPLNFTLPAGQRIALVGPSGAGKTS---LLNALLGflPYQGSLKINGIELRELDPESWRKHLSWVGQNPQLPHG-TLRD 441

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 100 NITvvprmLGwdkkRCHARAEELMSMVAL-DPKRFLHRYPK-----------EMSGGQQQRIGVIRALAADPPVLLMDEP 167
Cdd:PRK11174 442 NVL-----LG----NPDASDEQLQQALENaWVSEFLPLLPQgldtpigdqaaGLSVGQAQRLALARALLQPCQLLLLDEP 512

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727180512 168 FGAVDPINRETIQNEFLDMQRQlkKTVMLVSHDIDEaLKLGDRIAVFRQGKIVQNASADEL 228
Cdd:PRK11174 513 TASLDAHSEQLVMQALNAASRR--QTTLMVTHQLED-LAQWDQIWVMQDGQIVQQGDYAEL 570

ABC2_perm_RbbA

NF033858

ribosome-associated ATPase/putative transporter RbbA;

2-231

1.53e-22

ribosome-associated ATPase/putative transporter RbbA;

Pssm-ID: 468210 [Multi-domain] Cd Length: 907 Bit Score: 99.43 E-value: 1.53e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFmqknGTpFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDtVSLRRK 81
Cdd:NF033858 267 IEARGLTMRF----GD-FTAVDHVSFRIRRGEIFGFLGSNGCGKSTTMKMLTGLLPASEGEAWLFGQPVDAGD-IATRRR 340

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPkrFLHRYPKEMSGGQQQRIgvirALAA---- 157
Cdd:NF033858 341 VGYMSQAFSLYGELTVRQNLELHARLFHLPAAEIAARVAEMLERFDLAD--VADALPDSLPLGIRQRL----SLAVavih 414

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 727180512 158 DPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLgDRIAVFRQGKIVQNASADELLAR 231
Cdd:NF033858 415 KPELLILDEPTSGVDPVARDMFWRLLIELSREDGVTIFISTHFMNEAERC-DRISLMHAGRVLASDTPAALVAA 487

PRK15134

microcin C ABC transporter ATP-binding protein YejF; Provisional

1-236

1.68e-22

microcin C ABC transporter ATP-binding protein YejF; Provisional

Pssm-ID: 237917 [Multi-domain] Cd Length: 529 Bit Score: 99.01 E-value: 1.68e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQKnGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRL-----IEPTGGTILINGEDTSALDT 75
Cdd:PRK15134   5 LLAIENLSVAFRQQ-QTVRTVVNDVSLQIEAGETLALVGESGSGKSVTALSILRLlpsppVVYPSGDIRFHGESLLHASE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  76 VSLRR----KIGYVIQQ--IGLFPNMTIEENITVVpRMLGWDKKRCHARAEEL--MSMVAL-DPKRFLHRYPKEMSGGQQ 146
Cdd:PRK15134  84 QTLRGvrgnKIAMIFQEpmVSLNPLHTLEKQLYEV-LSLHRGMRREAARGEILncLDRVGIrQAAKRLTDYPHQLSGGER 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 147 QRIGVIRALAADPPVLLMDEPFGAVDPinreTIQNEFLDMQRQLKK----TVMLVSHDIDEALKLGDRIAVFRQGKIVQN 222
Cdd:PRK15134 163 QRVMIAMALLTRPELLIADEPTTALDV----SVQAQILQLLRELQQelnmGLLFITHNLSIVRKLADRVAVMQNGRCVEQ 238

                        250
                 ....*....|....
gi 727180512 223 ASADELLARPANEF 236
Cdd:PRK15134 239 NRAATLFSAPTHPY 252

PRK10584

putative ABC transporter ATP-binding protein YbbA; Provisional

25-223

1.74e-22

putative ABC transporter ATP-binding protein YbbA; Provisional

Pssm-ID: 182569 [Multi-domain] Cd Length: 228 Bit Score: 94.46 E-value: 1.74e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  25 INLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDT---VSLR-RKIGYVIQQIGLFPNMTIEEN 100
Cdd:PRK10584  29 VELVVKRGETIALIGESGSGKSTLLAILAGLDDGSSGEVSLVGQPLHQMDEearAKLRaKHVGFVFQSFMLIPTLNALEN 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 101 ITVVPRMLGWDKKRCHARAEELMSMVALDpKRfLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRETIQ 180
Cdd:PRK10584 109 VELPALLRGESSRQSRNGAKALLEQLGLG-KR-LDHLPAQLSGGEQQRVALARAFNGRPDVLFADEPTGNLDRQTGDKIA 186

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 727180512 181 NEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVfRQGKIVQNA 223
Cdd:PRK10584 187 DLLFSLNREHGTTLILVTHDLQLAARCDRRLRL-VNGQLQEEA 228

ABCG_White

cd03234

White pigment protein homolog of ABCG transporter subfamily; The White subfamily represents ...

24-220

2.62e-22

White pigment protein homolog of ABCG transporter subfamily; The White subfamily represents ABC transporters homologous to the Drosophila white gene, which acts as a dimeric importer for eye pigment precursors. The eye pigmentation of Drosophila is developed from the synthesis and deposition in the cells of red pigments, which are synthesized from guanine, and brown pigments, which are synthesized from tryptophan. The pigment precursors are encoded by the white, brown, and scarlet genes, respectively. Evidence from genetic and biochemical studies suggest that the White and Brown proteins function as heterodimers to import guanine, while the White and Scarlet proteins function to import tryptophan. However, a recent study also suggests that White may be involved in the transport of a metabolite, such as 3-hydroxykynurenine, across intracellular membranes. Mammalian ABC transporters belonging to the White subfamily (ABCG1, ABCG5, and ABCG8) have been shown to be involved in the regulation of lipid-trafficking mechanisms in macrophages, hepatocytes, and intestinal mucosa cells. ABCG1 (ABC8), the human homolog of the Drosophila white gene is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density lipoprotein. It is possible that human ABCG1 forms heterodimers with several heterologous partners.

Pssm-ID: 213201 [Multi-domain] Cd Length: 226 Bit Score: 93.87 E-value: 2.62e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  24 NINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEP---TGGTILINGEDTSAlDTVslRRKIGYVIQQIGLFPNMTIEEN 100
Cdd:cd03234   25 DVSLHVESGQVMAILGSSGSGKTTLLDAISGRVEGggtTSGQILFNGQPRKP-DQF--QKCVAYVRQDDILLPGLTVRET 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 101 ITVVPRMLGWDKKRCHARAEE----LMSMVALDPKRflHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPInr 176
Cdd:cd03234  102 LTYTAILRLPRKSSDAIRKKRvedvLLRDLALTRIG--GNLVKGISGGERRRVSIAVQLLWDPKVLILDEPTSGLDSF-- 177

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 727180512 177 etIQNEFLDMQRQL---KKTVMLVSHDI-DEALKLGDRIAVFRQGKIV 220
Cdd:cd03234  178 --TALNLVSTLSQLarrNRIVILTIHQPrSDLFRLFDRILLLSSGEIV 223

araG

PRK11288

L-arabinose ABC transporter ATP-binding protein AraG;

21-244

2.67e-22

L-arabinose ABC transporter ATP-binding protein AraG;

Pssm-ID: 183077 [Multi-domain] Cd Length: 501 Bit Score: 98.06 E-value: 2.67e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  21 AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGED---TSALDtvSLRRKIGYVIQQIGLFPNMTI 97
Cdd:PRK11288  19 ALDDISFDCRAGQVHALMGENGAGKSTLLKILSGNYQPDAGSILIDGQEmrfASTTA--ALAAGVAIIYQELHLVPEMTV 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  98 EENITV--VPRMLGW-DKKRCHARA-EELMSM-VALDPKRFLhrypKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVD 172
Cdd:PRK11288  97 AENLYLgqLPHKGGIvNRRLLNYEArEQLEHLgVDIDPDTPL----KYLSIGQRQMVEIAKALARNARVIAFDEPTSSLS 172

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727180512 173 piNRETIQneFLDMQRQLK---KTVMLVSHDIDEALKLGDRIAVFRQGKIVqnASADELLARPANEFVASFVGQD 244
Cdd:PRK11288 173 --AREIEQ--LFRVIRELRaegRVILYVSHRMEEIFALCDAITVFKDGRYV--ATFDDMAQVDRDQLVQAMVGRE 241

PRK10253

iron-enterobactin ABC transporter ATP-binding protein;

23-229

4.23e-22

iron-enterobactin ABC transporter ATP-binding protein;

Pssm-ID: 182336 [Multi-domain] Cd Length: 265 Bit Score: 94.28 E-value: 4.23e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  23 DNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRKIGYVIQQIGLFPNMTIEENIT 102
Cdd:PRK10253  24 ENLTVEIPDGHFTAIIGPNGCGKSTLLRTLSRLMTPAHGHVWLDGEHIQHYASKEVARRIGLLAQNATTPGDITVQELVA 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 103 V-----VPRMLGWDKKRCHARAEelmSMVALDPKRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDpINRE 177
Cdd:PRK10253 104 RgryphQPLFTRWRKEDEEAVTK---AMQATGITHLADQSVDTLSGGQRQRAWIAMVLAQETAIMLLDEPTTWLD-ISHQ 179

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 727180512 178 TIQNEFL-DMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELL 229
Cdd:PRK10253 180 IDLLELLsELNREKGYTLAAVLHDLNQACRYASHLIALREGKIVAQGAPKEIV 232

PRK10261

glutathione transporter ATP-binding protein; Provisional

1-241

1.04e-21

glutathione transporter ATP-binding protein; Provisional

Pssm-ID: 182342 [Multi-domain] Cd Length: 623 Bit Score: 96.85 E-value: 1.04e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQKNGtPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGE----------DT 70
Cdd:PRK10261  12 VLAVENLNIAFMQEQQ-KIAAVRNLSFSLQRGETLAIVGESGSGKSVTALALMRLLEQAGGLVQCDKMllrrrsrqviEL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  71 SALDTVSLRRKIGYVIQQI------GLFPNMTIEENITVVPRM-LGWDKKRCHARAEELMSMVAL-DPKRFLHRYPKEMS 142
Cdd:PRK10261  91 SEQSAAQMRHVRGADMAMIfqepmtSLNPVFTVGEQIAESIRLhQGASREEAMVEAKRMLDQVRIpEAQTILSRYPHQLS 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 143 GGQQQRIGVIRALAADPPVLLMDEPFGAVDPinreTIQNEFLD----MQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGK 218
Cdd:PRK10261 171 GGMRQRVMIAMALSCRPAVLIADEPTTALDV----TIQAQILQlikvLQKEMSMGVIFITHDMGVVAEIADRVLVMYQGE 246

                        250       260
                 ....*....|....*....|...
gi 727180512 219 IVQNASADELLARPANEFVASFV 241
Cdd:PRK10261 247 AVETGSVEQIFHAPQHPYTRALL 269

ABCC_TAP

cd03248

ATP-binding cassette domain of the Transporter Associated with Antigen Processing, subfamily C; ...

2-219

1.05e-21

ATP-binding cassette domain of the Transporter Associated with Antigen Processing, subfamily C; TAP (Transporter Associated with Antigen Processing) is essential for peptide delivery from the cytosol into the lumen of the endoplasmic reticulum (ER), where these peptides are loaded on major histocompatibility complex (MHC) I molecules. Loaded MHC I leave the ER and display their antigenic cargo on the cell surface to cytotoxic T cells. Subsequently, virus-infected or malignantly transformed cells can be eliminated. TAP belongs to the large family of ATP-binding cassette (ABC) transporters, which translocate a vast variety of solutes across membranes.

Pssm-ID: 213215 [Multi-domain] Cd Length: 226 Bit Score: 92.53 E-value: 1.05e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTkqFMQKNGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRK 81
Cdd:cd03248   12 VKFQNVT--FAYPTRPDTLVLQDVSFTLHPGEVTALVGPSGSGKSTVVALLENFYQPQGGQVLLDGKPISQYEHKYLHSK 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPNmTIEENI----TVVPRMLGWDKKRcHARAEELMSMVALDPKRFLHRYPKEMSGGQQQRIGVIRALAA 157
Cdd:cd03248   90 VSLVGQEPVLFAR-SLQDNIayglQSCSFECVKEAAQ-KAHAHSFISELASGYDTEVGEKGSQLSGGQKQRVAIARALIR 167

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727180512 158 DPPVLLMDEPFGAVDPINRETIQNEFLDMQRqlKKTVMLVSHDIdEALKLGDRIAVFRQGKI 219
Cdd:cd03248  168 NPQVLILDEATSALDAESEQQVQQALYDWPE--RRTVLVIAHRL-STVERADQILVLDGGRI 226

cbiO

PRK13638

energy-coupling factor ABC transporter ATP-binding protein;

25-231

5.49e-21

energy-coupling factor ABC transporter ATP-binding protein;

Pssm-ID: 184198 [Multi-domain] Cd Length: 271 Bit Score: 91.61 E-value: 5.49e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  25 INLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGE--DTSALDTVSLRRKIGYVIQQiglfPNMTI----- 97
Cdd:PRK13638  20 LNLDFSLSPVTGLVGANGCGKSTLFMNLSGLLRPQKGAVLWQGKplDYSKRGLLALRQQVATVFQD----PEQQIfytdi 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  98 EENITVVPRMLGWDKKRCHARAEELMSMValDPKRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRE 177
Cdd:PRK13638  96 DSDIAFSLRNLGVPEAEITRRVDEALTLV--DAQHFRHQPIQCLSHGQKKRVAIAGALVLQARYLLLDEPTAGLDPAGRT 173

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 727180512 178 TIQNEFLDMQRQlKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLAR 231
Cdd:PRK13638 174 QMIAIIRRIVAQ-GNHVIISSHDIDLIYEISDAVYVLRQGQILTHGAPGEVFAC 226

ABCG_EPDR

cd03213

Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette ...

5-220

7.13e-21

Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with processes in bacteria and higher eukaryotes. Compared to other members of the ABC transporter subfamilies, the ABCG transporter family is composed of proteins that have an ATP-binding cassette domain at the N-terminus and a TM (transmembrane) domain at the C-terminus.

Pssm-ID: 213180 [Multi-domain] Cd Length: 194 Bit Score: 89.15 E-value: 7.13e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   5 ENLTKQFMQKNGTPFNAV-DNINLDVPEGEICVLLGPSGCGKTTTLKMI-NRLIEP-TGGTILINGEDtsaLDTVSLRRK 81
Cdd:cd03213    7 RNLTVTVKSSPSKSGKQLlKNVSGKAKPGELTAIMGPSGAGKSTLLNALaGRRTGLgVSGEVLINGRP---LDKRSFRKI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPNMTIEENITVVPRMLGwdkkrcharaeelmsmvaldpkrflhrypkeMSGGQQQRIGVIRALAADPPV 161
Cdd:cd03213   84 IGYVPQDDILHPTLTVRETLMFAAKLRG-------------------------------LSGGERKRVSIALELVSNPSL 132

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727180512 162 LLMDEPFGAVDPINRETIqnefLDMQRQLK---KTVMLVSHDI-DEALKLGDRIAVFRQGKIV 220
Cdd:cd03213  133 LFLDEPTSGLDSSSALQV----MSLLRRLAdtgRTIICSIHQPsSEIFELFDKLLLLSQGRVI 191

CP_lyasePhnK

TIGR02323

phosphonate C-P lyase system protein PhnK; Members of this family are the PhnK protein of C-P ...

24-232

7.83e-21

phosphonate C-P lyase system protein PhnK; Members of this family are the PhnK protein of C-P lyase systems for utilization of phosphonates. These systems resemble phosphonatase-based systems in having a three component ABC transporter, where TIGR01097 is the permease, TIGR01098 is the phosphonates binding protein, and TIGR02315 is the ATP-binding cassette (ABC) protein. They differ, however, in having, typically, ten or more additional genes, many of which are believed to form a membrane-associated complex. This protein (PhnK) and the adjacent-encoded PhnL resemble transporter ATP-binding proteins but are suggested, based on mutatgenesis studies, to be part of this complex rather than part of a transporter per se. [Central intermediary metabolism, Phosphorus compounds]

Pssm-ID: 188208 [Multi-domain] Cd Length: 253 Bit Score: 90.66 E-value: 7.83e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   24 NINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSL----RRKI-----GYVIQQIGLFPN 94
Cdd:TIGR02323  21 DVSFDLYPGEVLGIVGESGSGKSTLLGCLAGRLAPDHGTATYIMRSGAELELYQLseaeRRRLmrtewGFVHQNPRDGLR 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   95 MTIEENITVVPRMLGWDKK---RCHARAEELMSMVALDPKRfLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAV 171
Cdd:TIGR02323 101 MRVSAGANIGERLMAIGARhygNIRATAQDWLEEVEIDPTR-IDDLPRAFSGGMQQRLQIARNLVTRPRLVFMDEPTGGL 179

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727180512  172 DPinreTIQNEFLDMQRQLKK----TVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARP 232
Cdd:TIGR02323 180 DV----SVQARLLDLLRGLVRdlglAVIIVTHDLGVARLLAQRLLVMQQGRVVESGLTDQVLDDP 240

Uup

COG0488

ATPase components of ABC transporters with duplicated ATPase domains [General function ...

4-200

2.07e-20

ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only];

Pssm-ID: 440254 [Multi-domain] Cd Length: 520 Bit Score: 92.44 E-value: 2.07e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   4 LENLTKQFmqknGTP--FnavDNINLDVPEGE-ICvLLGPSGCGKTTTLKMINRLIEPTGGTILINGedtsaldtvslRR 80
Cdd:COG0488    1 LENLSKSF----GGRplL---DDVSLSINPGDrIG-LVGRNGAGKSTLLKILAGELEPDSGEVSIPK-----------GL 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQQIGLFPNMTIEENI-TVVPRMlgWDKKRCHARAEELMSMVALDPKRF-------------------------- 133
Cdd:COG0488   62 RIGYLPQEPPLDDDLTVLDTVlDGDAEL--RALEAELEELEAKLAEPDEDLERLaelqeefealggweaearaeeilsgl 139

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727180512 134 ------LHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEpfgavdPIN---RETIQ--NEFLdmqRQLKKTVMLVSHD 200
Cdd:COG0488  140 gfpeedLDRPVSELSGGWRRRVALARALLSEPDLLLLDE------PTNhldLESIEwlEEFL---KNYPGTVLVVSHD 208

cbiO

PRK13640

energy-coupling factor transporter ATPase;

17-232

2.61e-20

energy-coupling factor transporter ATPase;

Pssm-ID: 184200 [Multi-domain] Cd Length: 282 Bit Score: 89.86 E-value: 2.61e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  17 TPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEP---TGGTILINGEDTSALDTVSLRRKIGYVIQQI-GLF 92
Cdd:PRK13640  18 SKKPALNDISFSIPRGSWTALIGHNGSGKSTISKLINGLLLPddnPNSKITVDGITLTAKTVWDIREKVGIVFQNPdNQF 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  93 PNMTIEENITV------VPRmlgwdkkrcharaEELMSMVA-----LDPKRFLHRYPKEMSGGQQQRIGVIRALAADPPV 161
Cdd:PRK13640  98 VGATVGDDVAFglenraVPR-------------PEMIKIVRdvladVGMLDYIDSEPANLSGGQKQRVAIAGILAVEPKI 164

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727180512 162 LLMDEPFGAVDPINRETIqnefLDMQRQLKK----TVMLVSHDIDEAlKLGDRIAVFRQGKIVQNASADELLARP 232
Cdd:PRK13640 165 IILDESTSMLDPAGKEQI----LKLIRKLKKknnlTVISITHDIDEA-NMADQVLVLDDGKLLAQGSPVEIFSKV 234

PRK15112

peptide ABC transporter ATP-binding protein SapF;

1-246

3.19e-20

peptide ABC transporter ATP-binding protein SapF;

Pssm-ID: 185067 [Multi-domain] Cd Length: 267 Bit Score: 89.08 E-value: 3.19e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQKNG----TPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTV 76
Cdd:PRK15112   4 LLEVRNLSKTFRYRTGwfrrQTVEAVKPLSFTLREGQTLAIIGENGSGKSTLAKMLAGMIEPTSGELLIDDHPLHFGDYS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  77 SLRRKIGYVIQ--QIGLFPNMTIEEnITVVPRML--GWDKKRCHARAEELMSMVALDPKRFLHrYPKEMSGGQQQRIGVI 152
Cdd:PRK15112  84 YRSQRIRMIFQdpSTSLNPRQRISQ-ILDFPLRLntDLEPEQREKQIIETLRQVGLLPDHASY-YPHMLAPGQKQRLGLA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 153 RALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARP 232
Cdd:PRK15112 162 RALILRPKVIIADEALASLDMSMRSQLINLMLELQEKQGISYIYVTQHLGMMKHISDQVLVMHQGEVVERGSTADVLASP 241

                        250
                 ....*....|....*...
gi 727180512 233 ANE----FVASFVGQDRT 246
Cdd:PRK15112 242 LHEltkrLIAGHFGEALT 259

PRK15439

autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional

1-228

6.06e-20

autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional

Pssm-ID: 185336 [Multi-domain] Cd Length: 510 Bit Score: 91.27 E-value: 6.06e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqkNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALdTVSLRR 80
Cdd:PRK15439  11 LLCARSISKQY---SGVE--VLKGIDFTLHAGEVHALLGGNGAGKSTLMKIIAGIVPPDSGTLEIGGNPCARL-TPAKAH 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIG-YVI-QQIGLFPNMTIEENITV-VPRMLGwDKKRCHARAEELMSMVALDpkrflhrypkeMSGG-----QQQRIGVI 152
Cdd:PRK15439  85 QLGiYLVpQEPLLFPNLSVKENILFgLPKRQA-SMQKMKQLLAALGCQLDLD-----------SSAGslevaDRQIVEIL 152

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727180512 153 RALAADPPVLLMDEPFGAVDPINRETIqneFLDMQRQLKKTVMLV--SHDIDEALKLGDRIAVFRQGKIVQNASADEL 228
Cdd:PRK15439 153 RGLMRDSRILILDEPTASLTPAETERL---FSRIRELLAQGVGIVfiSHKLPEIRQLADRISVMRDGTIALSGKTADL 227

ABCC_MRP_domain2

cd03244

ATP-binding cassette domain 2 of multidrug resistance-associated protein; The ABC subfamily C ...

2-221

1.43e-19

ATP-binding cassette domain 2 of multidrug resistance-associated protein; The ABC subfamily C is also known as MRP (multidrug resistance-associated protein). Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resistance lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions, such as glutathione, glucuronate, and sulfate.

Pssm-ID: 213211 [Multi-domain] Cd Length: 221 Bit Score: 86.39 E-value: 1.43e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTkqFMQKNGTPfNAVDNINLDVPEGE---ICvllGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSL 78
Cdd:cd03244    3 IEFKNVS--LRYRPNLP-PVLKNISFSIKPGEkvgIV---GRTGSGKSSLLLALFRLVELSSGSILIDGVDISKIGLHDL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  79 RRKIGYVIQQIGLFPNmTIEENITvvPrmLG-------WD-------KKRCHARAEELMSMVALDPKRFlhrypkemSGG 144
Cdd:cd03244   77 RSRISIIPQDPVLFSG-TIRSNLD--P--FGeysdeelWQalervglKEFVESLPGGLDTVVEEGGENL--------SVG 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 145 QQQRIGVIRALAADPPVLLMDEPFGAVDPIN----RETIQNEFLDmqrqlkKTVMLVSHDIDEALKLgDRIAVFRQGKIV 220
Cdd:cd03244  144 QRQLLCLARALLRKSKILVLDEATASVDPETdaliQKTIREAFKD------CTVLTIAHRLDTIIDS-DRILVLDKGRVV 216


                 .
gi 727180512 221 Q 221
Cdd:cd03244  217 E 217

Uup

COG0488

ATPase components of ABC transporters with duplicated ATPase domains [General function ...

1-220

3.88e-19

ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only];

Pssm-ID: 440254 [Multi-domain] Cd Length: 520 Bit Score: 88.58 E-value: 3.88e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqkNGTPFnaVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILInGEdtsaldTVslrr 80
Cdd:COG0488  315 VLELEGLSKSY---GDKTL--LDDLSLRIDRGDRIGLIGPNGAGKSTLLKLLAGELEPDSGTVKL-GE------TV---- 378

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQ-QIGLFPNMTIEENItvvpRMLGWDKKRCHARaeelmSMVAldpkRFL------HRYPKEMSGGQQQRIGVIR 153
Cdd:COG0488  379 KIGYFDQhQEELDPDKTVLDEL----RDGAPGGTEQEVR-----GYLG----RFLfsgddaFKPVGVLSGGEKARLALAK 445

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727180512 154 ALAADPPVLLMDEPFGAVDPinrETIQ--NEFLDmqrQLKKTVMLVSHD---IDealKLGDRIAVFRQGKIV 220
Cdd:COG0488  446 LLLSPPNVLLLDEPTNHLDI---ETLEalEEALD---DFPGTVLLVSHDryfLD---RVATRILEFEDGGVR 508

PRK09700

D-allose ABC transporter ATP-binding protein AlsA;

22-227

5.08e-19

D-allose ABC transporter ATP-binding protein AlsA;

Pssm-ID: 182036 [Multi-domain] Cd Length: 510 Bit Score: 88.30 E-value: 5.08e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  22 VDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGED---TSALDtvSLRRKIGYVIQ---QIGLFPNM 95
Cdd:PRK09700 279 VRDISFSVCRGEILGFAGLVGSGRTELMNCLFGVDKRAGGEIRLNGKDispRSPLD--AVKKGMAYITEsrrDNGFFPNF 356

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  96 TIEENITVVP--RMLGW----------DKKRCHARAEELMSMVALDpkrfLHRYPKEMSGGQQQRIGVIRALAADPPVLL 163
Cdd:PRK09700 357 SIAQNMAISRslKDGGYkgamglfhevDEQRTAENQRELLALKCHS----VNQNITELSGGNQQKVLISKWLCCCPEVII 432

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 727180512 164 MDEPFGAVDpINRETiqnEFLDMQRQLK---KTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADE 227
Cdd:PRK09700 433 FDEPTRGID-VGAKA---EIYKVMRQLAddgKVILMVSSELPEIITVCDRIAVFCEGRLTQILTNRD 495

PRK13549

xylose transporter ATP-binding subunit; Provisional

1-250

1.10e-18

xylose transporter ATP-binding subunit; Provisional

Pssm-ID: 184134 [Multi-domain] Cd Length: 506 Bit Score: 87.29 E-value: 1.10e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqkNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRlIEPTG---GTILINGEDTSAlDTVS 77
Cdd:PRK13549   5 LLEMKNITKTF---GGVK--ALDNVSLKVRAGEIVSLCGENGAGKSTLMKVLSG-VYPHGtyeGEIIFEGEELQA-SNIR 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  78 LRRKIGYVI--QQIGLFPNMTIEENItvvprMLG----------WDKkrCHARAEELMSMVALD--PkrflHRYPKEMSG 143
Cdd:PRK13549  78 DTERAGIAIihQELALVKELSVLENI-----FLGneitpggimdYDA--MYLRAQKLLAQLKLDinP----ATPVGNLGL 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 144 GQQQRIGVIRALAADPPVLLMDEPFGAVdpINRETIQneFLDMQRQLKK---TVMLVSHDIDEALKLGDRIAVFRQGKIV 220
Cdd:PRK13549 147 GQQQLVEIAKALNKQARLLILDEPTASL--TESETAV--LLDIIRDLKAhgiACIYISHKLNEVKAISDTICVIRDGRHI 222

                        250       260       270
                 ....*....|....*....|....*....|
gi 727180512 221 QNASADELlarPANEFVASFVGqdRTLKRL 250
Cdd:PRK13549 223 GTRPAAGM---TEDDIITMMVG--RELTAL 247

ccmA

TIGR01189

heme ABC exporter, ATP-binding protein CcmA; This model describes the cyt c biogenesis protein ...

13-173

1.11e-18

heme ABC exporter, ATP-binding protein CcmA; This model describes the cyt c biogenesis protein encoded by ccmA in bacteria. An exception is, an arabidopsis protein. Quite likely this is encoded by an organelle. Bacterial c-type cytocromes are located on the periplasmic side of the cytoplasmic membrane. Several gene products encoded in a locus designated as 'ccm' are implicated in the transport and assembly of the functional cytochrome C. This cluster includes genes: ccmA;B;C;D;E;F;G and H. The posttranslational pathway includes the transport of heme moiety, the secretion of the apoprotein and the covalent attachment of the heme with the apoprotein. The proteins ccmA and B represent an ABC transporter; ccmC and D participate in heme transfer to ccmE, which function as a periplasmic heme chaperone. The presence of ccmF, G and H is suggested to be obligatory for the final functional assembly of cytochrome c. [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Other]

Pssm-ID: 273491 [Multi-domain] Cd Length: 198 Bit Score: 83.18 E-value: 1.11e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   13 QKNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALdTVSLRRKIGYVIQQIGLF 92
Cdd:TIGR01189   9 SRGERM--LFEGLSFTLNAGEALQVTGPNGIGKTTLLRILAGLLRPDSGEVRWNGTPLAEQ-RDEPHENILYLGHLPGLK 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   93 PNMTIEENITVVPRMLGWDKKRCHArAEELMSMVALDpkrflHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVD 172
Cdd:TIGR01189  86 PELSALENLHFWAAIHGGAQRTIED-ALAAVGLTGFE-----DLPAAQLSAGQQRRLALARLWLSRRPLWILDEPTTALD 159


                  .
gi 727180512  173 P 173
Cdd:TIGR01189 160 K 160

ABCF_EF-3

cd03221

ATP-binding cassette domain of elongation factor 3, subfamily F; Elongation factor 3 (EF-3) is ...

2-218

1.28e-18

ATP-binding cassette domain of elongation factor 3, subfamily F; Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated release of the deacylated tRNA from the E site. The reaction requires ATP hydrolysis. EF-3 contains two ATP nucleotide binding sequence (NBS) motifs. NBSI is sufficient for the intrinsic ATPase activity. NBSII is essential for the ribosome-stimulated functions.

Pssm-ID: 213188 [Multi-domain] Cd Length: 144 Bit Score: 81.34 E-value: 1.28e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFmqKNGTPFNavdNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTIlingedtsaldTVSLRRK 81
Cdd:cd03221    1 IELENLSKTY--GGKLLLK---DISLTINPGDRIGLVGRNGAGKSTLLKLIAGELEPDEGIV-----------TWGSTVK 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQqiglfpnmtieenitvvprmlgwdkkrcharaeelmsmvaldpkrflhrypkeMSGGQQQRIGVIRALAADPPV 161
Cdd:cd03221   65 IGYFEQ-----------------------------------------------------LSGGEKMRLALAKLLLENPNL 91

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 162 LLMDEPFGAVDPINRETIQNEFldmqRQLKKTVMLVSHD---IDealKLGDRIAVFRQGK 218
Cdd:cd03221   92 LLLDEPTNHLDLESIEALEEAL----KEYPGTVILVSHDryfLD---QVATKIIELEDGK 144

rim_protein

TIGR01257

retinal-specific rim ABC transporter; This model describes the photoreceptor protein (rim ...

1-217

1.89e-18

Pssm-ID: 130324 [Multi-domain] Cd Length: 2272 Bit Score: 87.38 E-value: 1.89e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512     1 MIKLENLTKQFmqkNGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMInrliepTGGTILINGEDT----SALDTV 76
Cdd:TIGR01257 1937 ILRLNELTKVY---SGTSSPAVDRLCVGVRPGECFGLLGVNGAGKTTTFKML------TGDTTVTSGDATvagkSILTNI 2007

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512    77 S-LRRKIGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEelMSMVALDPKRFLHRYPKEMSGGQQQRIGVIRAL 155
Cdd:TIGR01257 2008 SdVHQNMGYCPQFDAIDDLLTGREHLYLYARLRGVPAEEIEKVAN--WSIQSLGLSLYADRLAGTYSGGNKRKLSTAIAL 2085

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727180512   156 AADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQlKKTVMLVSHDIDEALKLGDRIAVFRQG 217
Cdd:TIGR01257 2086 IGCPPLVLLDEPTTGMDPQARRMLWNTIVSIIRE-GRAVVLTSHSMEECEALCTRLAIMVKG 2146

ABC2_perm_RbbA

NF033858

ribosome-associated ATPase/putative transporter RbbA;

21-231

2.17e-18

ribosome-associated ATPase/putative transporter RbbA;

Pssm-ID: 468210 [Multi-domain] Cd Length: 907 Bit Score: 87.10 E-value: 2.17e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  21 AVDNINLDVPEGEICVLLGPSGCGKTTTLKMIN--RLIEptGGTILINGED-TSALDTVSLRRKIGYVIQQIG--LFPNM 95
Cdd:NF033858  16 ALDDVSLDIPAGCMVGLIGPDGVGKSSLLSLIAgaRKIQ--QGRVEVLGGDmADARHRRAVCPRIAYMPQGLGknLYPTL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  96 TIEENITVVPRMLGWDKKRCHARAEELMSMVALDPkrFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPIN 175
Cdd:NF033858  94 SVFENLDFFGRLFGQDAAERRRRIDELLRATGLAP--FADRPAGKLSGGMKQKLGLCCALIHDPDLLILDEPTTGVDPLS 171

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727180512 176 R-------ETIQNEFLDMqrqlkkTVMLVSHDIDEALKLgDRIAVFRQGKIVQNASADELLAR 231
Cdd:NF033858 172 RrqfweliDRIRAERPGM------SVLVATAYMEEAERF-DWLVAMDAGRVLATGTPAELLAR 227

PRK13539

cytochrome c biogenesis protein CcmA; Provisional

24-172

2.75e-18

cytochrome c biogenesis protein CcmA; Provisional

Pssm-ID: 237421 [Multi-domain] Cd Length: 207 Bit Score: 82.23 E-value: 2.75e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  24 NINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTsalDTVSLRRKIGYVIQQIGLFPNMTIEENITV 103
Cdd:PRK13539  20 GLSFTLAAGEALVLTGPNGSGKTTLLRLIAGLLPPAAGTIKLDGGDI---DDPDVAEACHYLGHRNAMKPALTVAENLEF 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 727180512 104 VPRMLGWDKKRCHARAEelmsMVALDPkrFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVD 172
Cdd:PRK13539  97 WAAFLGGEELDIAAALE----AVGLAP--LAHLPFGYLSAGQKRRVALARLLVSNRPIWILDEPTAALD 159

znuC

PRK09544

high-affinity zinc transporter ATPase; Reviewed

1-211

2.37e-17

high-affinity zinc transporter ATPase; Reviewed

Pssm-ID: 181939 [Multi-domain] Cd Length: 251 Bit Score: 80.93 E-value: 2.37e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQKNgtpfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTIlingEDTSALdtvslrr 80
Cdd:PRK09544   4 LVSLENVSVSFGQRR-----VLSDVSLELKPGKILTLLGPNGAGKSTLVRVVLGLVAPDEGVI----KRNGKL------- 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQQIGLFPNMTIeenitVVPRMLgwdKKRCHARAEELMSMVALDPKRFLHRYP-KEMSGGQQQRIGVIRALAADP 159
Cdd:PRK09544  68 RIGYVPQKLYLDTTLPL-----TVNRFL---RLRPGTKKEDILPALKRVQAGHLIDAPmQKLSGGETQRVLLARALLNRP 139

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 160 PVLLMDEPFGAVDpINRETIQNEFLD-MQRQLKKTVMLVSHDI-------DEALKLGDRI 211
Cdd:PRK09544 140 QLLVLDEPTQGVD-VNGQVALYDLIDqLRRELDCAVLMVSHDLhlvmaktDEVLCLNHHI 198

40850658_otr

NF000106

oxytetracycline efflux ABC transporter Otr(C) ATP-binding subunit;

2-228

3.72e-17

oxytetracycline efflux ABC transporter Otr(C) ATP-binding subunit;

Pssm-ID: 411078 [Multi-domain] Cd Length: 351 Bit Score: 81.71 E-value: 3.72e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFMQkngtpFNAVDNINLDVPEGEICVLLGPSGCGKTTTlKMINRLIEPTGGTILINGEdTSALDTVSLRRK 81
Cdd:NF000106  14 VEVRGLVKHFGE-----VKAVDGVDLDVREGTVLGVLGP*GAA**RG-ALPAHV*GPDAGRRPWRF*-TWCANRRALRRT 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IG-YVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIGVIRALAADPP 160
Cdd:NF000106  87 IG*HRPVR*GRRESFSGRENLYMIGR*LDLSRKDARARADELLERFSLTEAA--GRAAAKYSGGMRRRLDLAASMIGRPA 164

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727180512 161 VLLMDEPFGAVDPINRETIQNEFLDMQRQlKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADEL 228
Cdd:NF000106 165 VLYLDEPTTGLDPRTRNEVWDEVRSMVRD-GATVLLTTQYMEEAEQLAHELTVIDRGRVIADGKVDEL 231

cbiO

PRK13648

cobalt transporter ATP-binding subunit; Provisional

1-228

4.05e-17

cobalt transporter ATP-binding subunit; Provisional

Pssm-ID: 184207 [Multi-domain] Cd Length: 269 Bit Score: 80.57 E-value: 4.05e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqKNGTPFnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRR 80
Cdd:PRK13648   7 IIVFKNVSFQY--QSDASF-TLKDVSFNIPKGQWTSIVGHNGSGKSTIAKLMIGIEKVKSGEIFYNNQAITDDNFEKLRK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQQI-GLFPNMTIE-------ENITVvprmlgwDKKRCHARAEELMSMVALDPKRflHRYPKEMSGGQQQRIGVI 152
Cdd:PRK13648  84 HIGIVFQNPdNQFVGSIVKydvafglENHAV-------PYDEMHRRVSEALKQVDMLERA--DYEPNALSGGQKQRVAIA 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 153 RALAADPPVLLMDEPFGAVDPINREtiqnEFLDMQRQLKK----TVMLVSHDIDEALKlGDRIAVFRQGKIVQNASADEL 228
Cdd:PRK13648 155 GVLALNPSVIILDEATSMLDPDARQ----NLLDLVRKVKSehniTIISITHDLSEAME-ADHVIVMNKGTVYKEGTPTEI 229

ABC_RNaseL_inhibitor_domain2

cd03237

The ATP-binding cassette domain 2 of RNase L inhibitor; The ABC ATPase, RNase L inhibitor (RLI) ...

28-249

4.40e-17

The ATP-binding cassette domain 2 of RNase L inhibitor; The ABC ATPase, RNase L inhibitor (RLI), is a key enzyme in ribosomal biogenesis, formation of translation preinitiation complexes, and assembly of HIV capsids. RLI's are not transport proteins and thus cluster with a group of soluble proteins that lack the transmembrane components commonly found in other members of the family. Structurally, RLI's have an N-terminal Fe-S domain and two nucleotide-binding domains which are arranged to form two composite active sites in their interface cleft. RLI is one of the most conserved enzymes between archaea and eukaryotes with a sequence identity of more than 48%. The high degree of evolutionary conservation suggests that RLI performs a central role in archaeal and eukaryotic physiology.

Pssm-ID: 213204 [Multi-domain] Cd Length: 246 Bit Score: 79.76 E-value: 4.40e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  28 DVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILIngedtsALDTVSlrrkigYVIQQIGLFPNMTIEENI-TVVPR 106
Cdd:cd03237   21 SISESEVIGILGPNGIGKTTFIKMLAGVLKPDEGDIEI------ELDTVS------YKPQYIKADYEGTVRDLLsSITKD 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 107 MLGWDKKRcharaEELMSMVALDPkrFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINR---ETIQNEF 183
Cdd:cd03237   89 FYTHPYFK-----TEIAKPLQIEQ--ILDREVPELSGGELQRVAIAACLSKDADIYLLDEPSAYLDVEQRlmaSKVIRRF 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727180512 184 LDMQrqlKKTVMLVSHDIDEALKLGDRIAVFrQGKIVQN--ASADELLARPANEFVASFvgqDRTLKR 249
Cdd:cd03237  162 AENN---EKTAFVVEHDIIMIDYLADRLIVF-EGEPSVNgvANPPQSLRSGMNRFLKNL---DITFRR 222

PvdE

COG4615

ABC-type siderophore export system, fused ATPase and permease components [Inorganic ion ...

2-231

6.85e-17

ABC-type siderophore export system, fused ATPase and permease components [Inorganic ion transport and metabolism];

Pssm-ID: 443659 [Multi-domain] Cd Length: 547 Bit Score: 82.15 E-value: 6.85e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFMQKNGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRK 81
Cdd:COG4615  328 LELRGVTYRYPGEDGDEGFTLGPIDLTIRRGELVFIVGGNGSGKSTLAKLLTGLYRPESGEILLDGQPVTADNREAYRQL 407

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFpnmtieenitvvPRMLGWDKKRCHARAEELMSMVALDPK------RFLHRypkEMSGGQQQRIGVIRAL 155
Cdd:COG4615  408 FSAVFSDFHLF------------DRLLGLDGEADPARARELLERLELDHKvsvedgRFSTT---DLSQGQRKRLALLVAL 472

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 727180512 156 AADPPVLLMDEpFGA-VDPINRETIQNEFLDMQRQLKKTVMLVSHDiDEALKLGDRIAVFRQGKIVQNASADELLAR 231
Cdd:COG4615  473 LEDRPILVFDE-WAAdQDPEFRRVFYTELLPELKARGKTVIAISHD-DRYFDLADRVLKMDYGKLVELTGPAALAAS 547

GguA

NF040905

sugar ABC transporter ATP-binding protein;

21-221

1.13e-16

sugar ABC transporter ATP-binding protein;

Pssm-ID: 468840 [Multi-domain] Cd Length: 500 Bit Score: 81.37 E-value: 1.13e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  21 AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRlIEPTG---GTILINGEdTSALDTVSLRRKIGYVI--QQIGLFPNM 95
Cdd:NF040905  16 ALDDVNLSVREGEIHALCGENGAGKSTLMKVLSG-VYPHGsyeGEILFDGE-VCRFKDIRDSEALGIVIihQELALIPYL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  96 TIEENItvvprMLG----------WDkkRCHARAEELMSMVALD--PKRFLhrypKEMSGGQQQRIGVIRALAADPPVLL 163
Cdd:NF040905  94 SIAENI-----FLGnerakrgvidWN--ETNRRARELLAKVGLDesPDTLV----TDIGVGKQQLVEIAKALSKDVKLLI 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727180512 164 MDEPFGAvdpINRETIQNeFLDMQRQLKK---TVMLVSHDIDEALKLGDRIAVFRQGKIVQ 221
Cdd:NF040905 163 LDEPTAA---LNEEDSAA-LLDLLLELKAqgiTSIIISHKLNEIRRVADSITVLRDGRTIE 219

ABCC_SUR1_N

cd03290

ATP-binding cassette domain of the sulfonylurea receptor, subfamily C; The SUR domain 1. The ...

16-217

1.86e-16

ATP-binding cassette domain of the sulfonylurea receptor, subfamily C; The SUR domain 1. The sulfonylurea receptor SUR is an ATP transporter of the ABCC/MRP family with tandem ATPase binding domains. Unlike other ABC proteins, it has no intrinsic transport function, neither active nor passive, but associates with the potassium channel proteins Kir6.1 or Kir6.2 to form the ATP-sensitive potassium (K(ATP)) channel. Within the channel complex, SUR serves as a regulatory subunit that fine-tunes the gating of Kir6.x in response to alterations in cellular metabolism. It constitutes a major pharmaceutical target as it binds numerous drugs, K(ATP) channel openers and blockers, capable of up- or down-regulating channel activity.

Pssm-ID: 213257 [Multi-domain] Cd Length: 218 Bit Score: 77.37 E-value: 1.86e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  16 GTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTIL---INGEDTSALDTVSLRR-KIGYVIQQIGL 91
Cdd:cd03290   11 GSGLATLSNINIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHwsnKNESEPSFEATRSRNRySVAYAAQKPWL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  92 FpNMTIEENITV-VPrmlgWDKKRCHAraeeLMSMVALDPKRFLHRYPKE---------MSGGQQQRIGVIRALAADPPV 161
Cdd:cd03290   91 L-NATVEENITFgSP----FNKQRYKA----VTDACSLQPDIDLLPFGDQteigerginLSGGQRQRICVARALYQNTNI 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 727180512 162 LLMDEPFGAVD-PINRETIQNEFLDMQRQLKKTVMLVSHDIdEALKLGDRIAVFRQG 217
Cdd:cd03290  162 VFLDDPFSALDiHLSDHLMQEGILKFLQDDKRTLVLVTHKL-QYLPHADWIIAMKDG 217

PRK10789

SmdA family multidrug ABC transporter permease/ATP-binding protein;

21-232

5.40e-16

SmdA family multidrug ABC transporter permease/ATP-binding protein;

Pssm-ID: 182732 [Multi-domain] Cd Length: 569 Bit Score: 79.37 E-value: 5.40e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  21 AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRKIGYVIQQIGLFPNmTIEEN 100
Cdd:PRK10789 330 ALENVNFTLKPGQMLGICGPTGSGKSTLLSLIQRHFDVSEGDIRFHDIPLTKLQLDSWRSRLAVVSQTPFLFSD-TVANN 408

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 101 ITvvprmLGwdkkRCHARAEEL-----MSMVALDPKRFLHRYPKE-------MSGGQQQRIGVIRALAADPPVLLMDEPF 168
Cdd:PRK10789 409 IA-----LG----RPDATQQEIehvarLASVHDDILRLPQGYDTEvgergvmLSGGQKQRISIARALLLNAEILILDDAL 479

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727180512 169 GAVD-PINRETIQNefLDMQRQlKKTVMLVSHDIdEALKLGDRIAVFRQGKIVQNASADELLARP 232
Cdd:PRK10789 480 SAVDgRTEHQILHN--LRQWGE-GRTVIISAHRL-SALTEASEILVMQHGHIAQRGNHDQLAQQS 540

xylG

TIGR02633

D-xylose ABC transporter, ATP-binding protein; Several bacterial species have enzymes xylose ...

1-220

7.68e-16

D-xylose ABC transporter, ATP-binding protein; Several bacterial species have enzymes xylose isomerase and xylulokinase enzymes for xylose utilization. Members of this protein family are the ATP-binding cassette (ABC) subunit of the known or predicted high-affinity xylose ABC transporter for xylose import. These genes, which closely resemble other sugar transport ABC transporter genes, typically are encoded near xylose utilization enzymes and regulatory proteins. Note that this form of the transporter contains two copies of the ABC transporter domain (pfam00005). [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 131681 [Multi-domain] Cd Length: 500 Bit Score: 78.71 E-value: 7.68e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512    1 MIKLENLTKQFmqkngTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRlIEPTG---GTILINGEDTSALDTVS 77
Cdd:TIGR02633   1 LLEMKGIVKTF-----GGVKALDGIDLEVRPGECVGLCGENGAGKSTLMKILSG-VYPHGtwdGEIYWSGSPLKASNIRD 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   78 LRRKiGYVI--QQIGLFPNMTIEENI-----TVVPRMLGWDKKRCHaRAEELMSMVALDPKRfLHRYPKEMSGGQQQRIG 150
Cdd:TIGR02633  75 TERA-GIVIihQELTLVPELSVAENIflgneITLPGGRMAYNAMYL-RAKNLLRELQLDADN-VTRPVGDYGGGQQQLVE 151

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727180512  151 VIRALAADPPVLLMDEPFGAVDPINRETIqnefLDMQRQLKK---TVMLVSHDIDEALKLGDRIAVFRQGKIV 220
Cdd:TIGR02633 152 IAKALNKQARLLILDEPSSSLTEKETEIL----LDIIRDLKAhgvACVYISHKLNEVKAVCDTICVIRDGQHV 220

PTZ00265

multidrug resistance protein (mdr1); Provisional

61-230

8.26e-16

multidrug resistance protein (mdr1); Provisional

Pssm-ID: 240339 [Multi-domain] Cd Length: 1466 Bit Score: 79.30 E-value: 8.26e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   61 GTILINGEDTSALDTVSLRRKIGYVIQQIGLFpNMTIEENITVVPRMLGWD--KKRCH-ARAEELMSMValdPKRF---L 134
Cdd:PTZ00265 1277 GKILLDGVDICDYNLKDLRNLFSIVSQEPMLF-NMSIYENIKFGKEDATREdvKRACKfAAIDEFIESL---PNKYdtnV 1352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  135 HRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIdEALKLGDRIAVF 214
Cdd:PTZ00265 1353 GPYGKSLSGGQKQRIAIARALLREPKILLLDEATSSLDSNSEKLIEKTIVDIKDKADKTIITIAHRI-ASIKRSDKIVVF 1431

                         170       180
                  ....*....|....*....|.
gi 727180512  215 ----RQGKIVQ-NASADELLA 230
Cdd:PTZ00265 1432 nnpdRTGSFVQaHGTHEELLS 1452

PRK15439

autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional

24-219

1.61e-15

autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional

Pssm-ID: 185336 [Multi-domain] Cd Length: 510 Bit Score: 77.78 E-value: 1.61e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  24 NINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVS-LRRKIGYVI---QQIGLFPNMTIEE 99
Cdd:PRK15439 281 NISLEVRAGEILGLAGVVGAGRTELAETLYGLRPARGGRIMLNGKEINALSTAQrLARGLVYLPedrQSSGLYLDAPLAW 360

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 100 NIT--VVPRMLGW-DKKRCHARAEELMSMVALdpkRFLH--RYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPI 174
Cdd:PRK15439 361 NVCalTHNRRGFWiKPARENAVLERYRRALNI---KFNHaeQAARTLSGGNQQKVLIAKCLEASPQLLIVDEPTRGVDVS 437

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 727180512 175 NRETIQNEFLDMQRQlKKTVMLVSHDIDEALKLGDRIAVFRQGKI 219
Cdd:PRK15439 438 ARNDIYQLIRSIAAQ-NVAVLFISSDLEEIEQMADRVLVMHQGEI 481

BtuD

COG4138

ABC-type cobalamin transport system, ATPase component BtuD [Coenzyme transport and metabolism]; ...

22-234

1.94e-15

ABC-type cobalamin transport system, ATPase component BtuD [Coenzyme transport and metabolism];

Pssm-ID: 443313 [Multi-domain] Cd Length: 248 Bit Score: 75.26 E-value: 1.94e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  22 VDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIePTGGTILINGEDTSALDTVSLRRKIGYVIQQIGLFPNMTIEENI 101
Cdd:COG4138   12 LGPISAQVNAGELIHLIGPNGAGKSTLLARMAGLL-PGQGEILLNGRPLSDWSAAELARHRAYLSQQQSPPFAMPVFQYL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 102 TvvprmLGWDKKRCHARAEELMSMVA----LDPKrfLHRYPKEMSGGQQQRIGVIRAL-----AADPP--VLLMDEPFGA 170
Cdd:COG4138   91 A-----LHQPAGASSEAVEQLLAQLAealgLEDK--LSRPLTQLSGGEWQRVRLAAVLlqvwpTINPEgqLLLLDEPMNS 163

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 727180512 171 VDpINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLaRPAN 234
Cdd:COG4138  164 LD-VAQQAALDRLLRELCQQGITVVMSSHDLNHTLRHADRVWLLKQGKLVASGETAEVM-TPEN 225

ABCC_NFT1

cd03369

ATP-binding cassette domain 2 of NFT1, subfamily C; Domain 2 of NFT1 (New full-length MRP-type ...

2-224

2.48e-15

ATP-binding cassette domain 2 of NFT1, subfamily C; Domain 2 of NFT1 (New full-length MRP-type transporter 1). NFT1 belongs to the MRP (multidrug resistance-associated protein) family of ABC transporters. Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resisting lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions such as glutathione, glucuronate, and sulfate.

Pssm-ID: 213269 [Multi-domain] Cd Length: 207 Bit Score: 73.99 E-value: 2.48e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFmQKNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRK 81
Cdd:cd03369    7 IEVENLSVRY-APDLPP--VLKNVSFKVKAGEKIGIVGRTGAGKSTLILALFRFLEAEEGKIEIDGIDISTIPLEDLRSS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPNmTIEENITVVPrmlgwdkkrcHARAEELMSMVALdpkrflhrypKE----MSGGQQQRIGVIRALAA 157
Cdd:cd03369   84 LTIIPQDPTLFSG-TIRSNLDPFD----------EYSDEEIYGALRV----------SEgglnLSQGQRQLLCLARALLK 142

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727180512 158 DPPVLLMDEPFGAVDPIN----RETIQNEFLDmqrqlkKTVMLVSHDIDEALKLgDRIAVFRQGKIVQNAS 224
Cdd:cd03369  143 RPRVLVLDEATASIDYATdaliQKTIREEFTN------STILTIAHRLRTIIDY-DKILVMDAGEVKEYDH 206

PRK10762

D-ribose transporter ATP binding protein; Provisional

1-226

3.80e-15

D-ribose transporter ATP binding protein; Provisional

Pssm-ID: 236755 [Multi-domain] Cd Length: 501 Bit Score: 76.58 E-value: 3.80e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFmqkngtP-FNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTS-ALDTVSL 78
Cdd:PRK10762   4 LLQLKGIDKAF------PgVKALSGAALNVYPGRVMALVGENGAGKSTMMKVLTGIYTRDAGSILYLGKEVTfNGPKSSQ 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  79 RRKIGYVIQQIGLFPNMTIEENI----TVVPRMLGWDKKRCHARAEELMSmvALDPKRFLHRYPKEMSGGQQQRIGVIRA 154
Cdd:PRK10762  78 EAGIGIIHQELNLIPQLTIAENIflgrEFVNRFGRIDWKKMYAEADKLLA--RLNLRFSSDKLVGELSIGEQQMVEIAKV 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727180512 155 LAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQlKKTVMLVSHDIDEALKLGDRIAVFRQGK-IVQNASAD 226
Cdd:PRK10762 156 LSFESKVIIMDEPTDALTDTETESLFRVIRELKSQ-GRGIVYISHRLKEIFEICDDVTVFRDGQfIAEREVAD 227

PRK03695

vitamin B12-transporter ATPase; Provisional

32-229

5.49e-15

vitamin B12-transporter ATPase; Provisional

Pssm-ID: 235150 [Multi-domain] Cd Length: 248 Bit Score: 73.81 E-value: 5.49e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  32 GEICVLLGPSGCGKTTTLKMINRLIePTGGTILINGEDTSALDTVSLRRKIGYVIQQIGLFPNMTieenitvVPRML--- 108
Cdd:PRK03695  22 GEILHLVGPNGAGKSTLLARMAGLL-PGSGSIQFAGQPLEAWSAAELARHRAYLSQQQTPPFAMP-------VFQYLtlh 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 109 ---GWDKKRCHARAEELMSMVALDPKrfLHRYPKEMSGGQQQRI---GVI----RALAADPPVLLMDEPFGAVDpINRET 178
Cdd:PRK03695  94 qpdKTRTEAVASALNEVAEALGLDDK--LGRSVNQLSGGEWQRVrlaAVVlqvwPDINPAGQLLLLDEPMNSLD-VAQQA 170

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 727180512 179 IQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELL 229
Cdd:PRK03695 171 ALDRLLSELCQQGIAVVMSSHDLNHTLRHADRVWLLKQGKLLASGRRDEVL 221

PTZ00265

multidrug resistance protein (mdr1); Provisional

24-199

1.02e-14

multidrug resistance protein (mdr1); Provisional

Pssm-ID: 240339 [Multi-domain] Cd Length: 1466 Bit Score: 75.84 E-value: 1.02e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   24 NINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINgeDTSALDTVSL---RRKIGYVIQQIGLFPNmTIEEN 100
Cdd:PTZ00265  403 DLNFTLTEGKTYAFVGESGCGKSTILKLIERLYDPTEGDIIIN--DSHNLKDINLkwwRSKIGVVSQDPLLFSN-SIKNN 479

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  101 ITVVPRML-------------------GWDKKR-CHAR-------------AEELMSM------------VALDPKRFLH 135
Cdd:PTZ00265  480 IKYSLYSLkdlealsnyynedgndsqeNKNKRNsCRAKcagdlndmsnttdSNELIEMrknyqtikdsevVDVSKKVLIH 559

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 727180512  136 RY---------------PKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSH 199
Cdd:PTZ00265  560 DFvsalpdkyetlvgsnASKLSGGQKQRISIARAIIRNPKILILDEATSSLDNKSEYLVQKTINNLKGNENRITIIIAH 638

PRK13546

teichoic acids export ABC transporter ATP-binding subunit TagH;

2-240

2.55e-14

teichoic acids export ABC transporter ATP-binding subunit TagH;

Pssm-ID: 184131 [Multi-domain] Cd Length: 264 Bit Score: 72.16 E-value: 2.55e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFM----------------QKNGTpFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILI 65
Cdd:PRK13546   5 VNIKNVTKEYRiyrtnkermkdalipkHKNKT-FFALDDISLKAYEGDVIGLVGINGSGKSTLSNIIGGSLSPTVGKVDR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  66 NGEdtsaldtvslrrkIGYVIQQIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMVALDpkRFLHRYPKEMSGGQ 145
Cdd:PRK13546  84 NGE-------------VSVIAISAGLSGQLTGIENIEFKMLCMGFKRKEIKAMTPKIIEFSELG--EFIYQPVKKYSSGM 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 146 QQRIGVIRALAADPPVLLMDEPFGAVDpinrETIQNEFLDMQRQLK---KTVMLVSHDIDEALKLGDRIAVFRQGKIVQN 222
Cdd:PRK13546 149 RAKLGFSINITVNPDILVIDEALSVGD----QTFAQKCLDKIYEFKeqnKTIFFVSHNLGQVRQFCTKIAWIEGGKLKDY 224

                        250
                 ....*....|....*...
gi 727180512 223 ASADELLARpANEFVASF 240
Cdd:PRK13546 225 GELDDVLPK-YEAFLNDF 241

tagH

PRK13545

teichoic acids export protein ATP-binding subunit; Provisional

2-203

2.80e-14

teichoic acids export protein ATP-binding subunit; Provisional

Pssm-ID: 184130 [Multi-domain] Cd Length: 549 Bit Score: 74.16 E-value: 2.80e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQ---------------FMQKNGTPFNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILIN 66
Cdd:PRK13545   5 VKFEHVTKKykmynkpfdklkdlfFRSKDGEYHYALNNISFEVPEGEIVGIIGLNGSGKSTLSNLIAGVTMPNKGTVDIK 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  67 GedTSALDTVSlrrkigyviqqIGLFPNMTIEENITVVPRMLGWDKKRCHARAEELMSMValDPKRFLHRYPKEMSGGQQ 146
Cdd:PRK13545  85 G--SAALIAIS-----------SGLNGQLTGIENIELKGLMMGLTKEKIKEIIPEIIEFA--DIGKFIYQPVKTYSSGMK 149

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 147 QRIGVIRALAADPPVLLMDEPFGAVDpinrETIQNEFLDMQRQLK---KTVMLVSHDIDE 203
Cdd:PRK13545 150 SRLGFAISVHINPDILVIDEALSVGD----QTFTKKCLDKMNEFKeqgKTIFFISHSLSQ 205

ABC_CcmA_heme_exporter

cd03231

Cytochrome c biogenesis ATP-binding export protein; CcmA, the ATP-binding component of the ...

32-172

3.31e-14

Cytochrome c biogenesis ATP-binding export protein; CcmA, the ATP-binding component of the bacterial CcmAB transporter. The CCM family is involved in bacterial cytochrome c biogenesis. Cytochrome c maturation in E. coli requires the ccm operon, which encodes eight membrane proteins (CcmABCDEFGH). CcmE is a periplasmic heme chaperon that binds heme covalently and transfers it onto apocytochrome c in the presence of CcmF, CcmG, and CcmH. The CcmAB proteins represent an ABC transporter and the CcmCD proteins participate in heme transfer to CcmE.

Pssm-ID: 213198 [Multi-domain] Cd Length: 201 Bit Score: 70.60 E-value: 3.31e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  32 GEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGedtSALDTV--SLRRKIGYVIQQIGLFPNMTIEENITVvprmlg 109
Cdd:cd03231   26 GEALQVTGPNGSGKTTLLRILAGLSPPLAGRVLLNG---GPLDFQrdSIARGLLYLGHAPGIKTTLSVLENLRF------ 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727180512 110 WdkKRCHARAEELMSMVALDPKRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVD 172
Cdd:cd03231   97 W--HADHSDEQVEEALARVGLNGFEDRPVAQLSAGQQRRVALARLLLSGRPLWILDEPTTALD 157

ABCD_peroxisomal_ALDP

cd03223

ATP-binding cassette domain of peroxisomal transporter, subfamily D; Peroxisomal ATP-binding ...

2-199

3.71e-14

ATP-binding cassette domain of peroxisomal transporter, subfamily D; Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed during fatty acid beta-oxidation. To communicate with the cytoplasm and mitochondria, peroxisomes need dedicated proteins to transport such hydrophilic molecules across their membranes. X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ALD gene, which encodes ALDP (adrenoleukodystrophy protein ), a peroxisomal integral membrane protein that is a member of the ATP-binding cassette (ABC) transporter protein family. The disease is characterized by a striking and unpredictable variation in phenotypic expression. Phenotypes include the rapidly progressive childhood cerebral form (CCALD), the milder adult form, adrenomyeloneuropathy (AMN), and variants without neurologic involvement (i.e. asymptomatic).

Pssm-ID: 213190 [Multi-domain] Cd Length: 166 Bit Score: 69.49 E-value: 3.71e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTkqFMQKNGTPFnaVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGedtsaldtvslRRK 81
Cdd:cd03223    1 IELENLS--LATPDGRVL--LKDLSFEIKPGDRLLITGPSGTGKSSLFRALAGLWPWGSGRIGMPE-----------GED 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQiGLFPNMTIEENITvvprmlgwdkkrcharaeelmsmvaldpkrflhrYP--KEMSGGQQQRIGVIRALAADP 159
Cdd:cd03223   66 LLFLPQR-PYLPLGTLREQLI----------------------------------YPwdDVLSGGEQQRLAFARLLLHKP 110

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 727180512 160 PVLLMDEPFGAVDpinrETIQNEFLDMQRQLKKTVMLVSH 199
Cdd:cd03223  111 KFVFLDEATSALD----EESEDRLYQLLKELGITVISVGH 146

PRK13540

cytochrome c biogenesis protein CcmA; Provisional

22-199

3.88e-14

cytochrome c biogenesis protein CcmA; Provisional

Pssm-ID: 184127 [Multi-domain] Cd Length: 200 Bit Score: 70.36 E-value: 3.88e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  22 VDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSAlDTVSLRRKIGYVIQQIGLFPNMTIEEN- 100
Cdd:PRK13540  17 LQQISFHLPAGGLLHLKGSNGAGKTTLLKLIAGLLNPEKGEILFERQSIKK-DLCTYQKQLCFVGHRSGINPYLTLRENc 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 101 ---ITVVPRMLGWDkkrcharaeELMSMVALDpkrFLHRYP-KEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINR 176
Cdd:PRK13540  96 lydIHFSPGAVGIT---------ELCRLFSLE---HLIDYPcGLLSSGQKRQVALLRLWMSKAKLWLLDEPLVALDELSL 163

                        170       180
                 ....*....|....*....|...
gi 727180512 177 ETIQNEfLDMQRQLKKTVMLVSH 199
Cdd:PRK13540 164 LTIITK-IQEHRAKGGAVLLTSH 185

MK0520

COG2401

ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction ...

19-221

5.62e-14

ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction only];

Pssm-ID: 441957 [Multi-domain] Cd Length: 222 Bit Score: 70.37 E-value: 5.62e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  19 FNAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIE--PTGGTIlingedtsaldtvslrrkigyVIQQIGLFPNMT 96
Cdd:COG2401   43 RYVLRDLNLEIEPGEIVLIVGASGSGKSTLLRLLAGALKgtPVAGCV---------------------DVPDNQFGREAS 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  97 IEENItvvprmlgwDKKRCHARAEELMSMVAL-DPKRFLHRYpKEMSGGQQQRIGVIRALAADPPVLLMDEpFGAVdpIN 175
Cdd:COG2401  102 LIDAI---------GRKGDFKDAVELLNAVGLsDAVLWLRRF-KELSTGQKFRFRLALLLAERPKLLVIDE-FCSH--LD 168

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 727180512 176 RETIQ---NEFLDMQRQLKKTVMLVSH--DIDEALKlGDRIAVFRQGKIVQ 221
Cdd:COG2401  169 RQTAKrvaRNLQKLARRAGITLVVATHhyDVIDDLQ-PDLLIFVGYGGVPE 218

PRK15056

manganese/iron ABC transporter ATP-binding protein;

21-201

6.26e-14

manganese/iron ABC transporter ATP-binding protein;

Pssm-ID: 185016 [Multi-domain] Cd Length: 272 Bit Score: 71.07 E-value: 6.26e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  21 AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSAldtvSLRRK-IGYVIQQIGL---FPNMT 96
Cdd:PRK15056  22 ALRDASFTVPGGSIAALVGVNGSGKSTLFKALMGFVRLASGKISILGQPTRQ----ALQKNlVAYVPQSEEVdwsFPVLV 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  97 ieENITVVPRM--LGW---DKKRCHARAEELMSMValDPKRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAV 171
Cdd:PRK15056  98 --EDVVMMGRYghMGWlrrAKKRDRQIVTAALARV--DMVEFRHRQIGELSGGQKKRVFLARAIAQQGQVILLDEPFTGV 173

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 727180512 172 DpinretIQNE--FLDMQRQLK---KTVMLVSHDI 201
Cdd:PRK15056 174 D------VKTEarIISLLRELRdegKTMLVSTHNL 202

oppD

PRK09473

oligopeptide transporter ATP-binding component; Provisional

21-233

9.54e-14

oligopeptide transporter ATP-binding component; Provisional

Pssm-ID: 181888 [Multi-domain] Cd Length: 330 Bit Score: 71.29 E-value: 9.54e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  21 AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTG---GTILINGEDTSALDTVSLRR----KIGYVIQQ--IGL 91
Cdd:PRK09473  31 AVNDLNFSLRAGETLGIVGESGSGKSQTAFALMGLLAANGrigGSATFNGREILNLPEKELNKlraeQISMIFQDpmTSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  92 FPNMTIEENITVVpRMLgwDKKRCHARA-EELMSMvaLDP-------KRfLHRYPKEMSGGQQQRIGVIRALAADPPVLL 163
Cdd:PRK09473 111 NPYMRVGEQLMEV-LML--HKGMSKAEAfEESVRM--LDAvkmpearKR-MKMYPHEFSGGMRQRVMIAMALLCRPKLLI 184

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 727180512 164 MDEPFGAVDPinreTIQNEFLDMQRQLKK----TVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLARPA 233
Cdd:PRK09473 185 ADEPTTALDV----TVQAQIMTLLNELKRefntAIIMITHDLGVVAGICDKVLVMYAGRTMEYGNARDVFYQPS 254

CBS_pair_SF

cd02205

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily; The CBS ...

262-363

9.73e-14

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).

Pssm-ID: 341358 [Multi-domain] Cd Length: 113 Bit Score: 66.88 E-value: 9.73e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 262 QETVTVRRETPLVEAFGLMDDIDARSVTVVDADGKPLGYVKRREARGAPG--------VCADSLHRFRVTARAEENLRVV 333
Cdd:cd02205    2 RDVVTVDPDTTVREALELMAENGIGALPVVDDDGKLVGIVTERDILRALVegglaldtPVAEVMTPDVITVSPDTDLEEA 81

                         90       100       110
                 ....*....|....*....|....*....|
gi 727180512 334 LSKLYEHNTSWMPIVDEDGRYSGEISQDYI 363
Cdd:cd02205   82 LELMLEHGIRRLPVVDDDGKLVGIVTRRDI 111

SufC

COG0396

Fe-S cluster assembly ATPase SufC [Posttranslational modification, protein turnover, ...

23-221

1.05e-13

Fe-S cluster assembly ATPase SufC [Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 440165 [Multi-domain] Cd Length: 245 Bit Score: 70.10 E-value: 1.05e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  23 DNINLDVPEGEICVLLGPSGCGKTTTLKMI--NRLIEPTGGTILINGEDTSALDtVSLRRK--IGYVIQQIGLFPNMTIE 98
Cdd:COG0396   17 KGVNLTIKPGEVHAIMGPNGSGKSTLAKVLmgHPKYEVTSGSILLDGEDILELS-PDERARagIFLAFQYPVEIPGVSVS 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  99 E------NITVVPRMlgwDKKRCHARAEELMSMVALDPKrFLHRYPKE-MSGGQQQRIGVIRALAADPPVLLMDEP---- 167
Cdd:COG0396   96 NflrtalNARRGEEL---SAREFLKLLKEKMKELGLDED-FLDRYVNEgFSGGEKKRNEILQMLLLEPKLAILDETdsgl 171

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727180512 168 ----FGAVdpinRETIqNEFldmqRQLKKTVMLVSH-----DIDEAlklgDRIAVFRQGKIVQ 221
Cdd:COG0396  172 didaLRIV----AEGV-NKL----RSPDRGILIITHyqrilDYIKP----DFVHVLVDGRIVK 221

3a01204

TIGR00955

The Eye Pigment Precursor Transporter (EPP) Family protein; [Transport and binding proteins, ...

31-229

1.10e-13

The Eye Pigment Precursor Transporter (EPP) Family protein; [Transport and binding proteins, Other]

Pssm-ID: 273361 [Multi-domain] Cd Length: 617 Bit Score: 72.39 E-value: 1.10e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   31 EGEICVLLGPSGCGKTTTLKMINRLIEP---TGGTILINGEdtsALDTVSLRRKIGYVIQQIGLFPNMTIEENITV---- 103
Cdd:TIGR00955  50 PGELLAVMGSSGAGKTTLMNALAFRSPKgvkGSGSVLLNGM---PIDAKEMRAISAYVQQDDLFIPTLTVREHLMFqahl 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  104 -VPRMLGWDKKRchARAEELMSMVAL---------DPKRFlhrypKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDP 173
Cdd:TIGR00955 127 rMPRRVTKKEKR--ERVDEVLQALGLrkcantrigVPGRV-----KGLSGGERKRLAFASELLTDPPLLFCDEPTSGLDS 199

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 727180512  174 INRETIQNEFLDMQrQLKKTVMLVSHD-IDEALKLGDRIAVFRQGKIVQNASADELL 229
Cdd:TIGR00955 200 FMAYSVVQVLKGLA-QKGKTIICTIHQpSSELFELFDKIILMAEGRVAYLGSPDQAV 255

MRP_assoc_pro

TIGR00957

multi drug resistance-associated protein (MRP); This model describes multi drug ...

22-231

1.46e-13

multi drug resistance-associated protein (MRP); This model describes multi drug resistance-associated protein (MRP) in eukaryotes. The multidrug resistance-associated protein is an integral membrane protein that causes multidrug resistance when overexpressed in mammalian cells. It belongs to ABC transporter superfamily. The protein topology and function was experimentally demonstrated by epitope tagging and immunofluorescence. Insertion of tags in the critical regions associated with drug efflux, abrogated its function. The C-terminal domain seem to highly conserved. [Transport and binding proteins, Other]

Pssm-ID: 188098 [Multi-domain] Cd Length: 1522 Bit Score: 72.29 E-value: 1.46e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512    22 VDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEdtsaldtvslrrkIGYVIQQiGLFPNMTIEENI 101
Cdd:TIGR00957  654 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVHMKGS-------------VAYVPQQ-AWIQNDSLRENI 719

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   102 tvvprMLGwdKKRCHARAEELMSMVALDPKrfLHRYPK-----------EMSGGQQQRIGVIRALAADPPVLLMDEPFGA 170
Cdd:TIGR00957  720 -----LFG--KALNEKYYQQVLEACALLPD--LEILPSgdrteigekgvNLSGGQKQRVSLARAVYSNADIYLFDDPLSA 790

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727180512   171 VDPINRETIQNEFLDMQRQLK-KTVMLVSHDIdEALKLGDRIAVFRQGKIVQNASADELLAR 231
Cdd:TIGR00957  791 VDAHVGKHIFEHVIGPEGVLKnKTRILVTHGI-SYLPQVDVIIVMSGGKISEMGSYQELLQR 851

PRK10522

multidrug transporter membrane component/ATP-binding component; Provisional

2-219

3.95e-13

multidrug transporter membrane component/ATP-binding component; Provisional

Pssm-ID: 236707 [Multi-domain] Cd Length: 547 Bit Score: 70.39 E-value: 3.95e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFmQKNGtpFnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRK 81
Cdd:PRK10522 323 LELRNVTFAY-QDNG--F-SVGPINLTIKRGELLFLIGGNGSGKSTLAMLLTGLYQPQSGEILLDGKPVTAEQPEDYRKL 398

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPNMTIEENITVVPRMLG-WDKKRcharaeELMSMVALDPKRFLHrypKEMSGGQQQRIGVIRALAADPP 160
Cdd:PRK10522 399 FSAVFTDFHLFDQLLGPEGKPANPALVEkWLERL------KMAHKLELEDGRISN---LKLSKGQKKRLALLLALAEERD 469

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 727180512 161 VLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDiDEALKLGDRIAVFRQGKI 219
Cdd:PRK10522 470 ILLLDEWAADQDPHFRREFYQVLLPLLQEMGKTIFAISHD-DHYFIHADRLLEMRNGQL 527

ABCG_PDR_domain1

cd03233

First domain of the pleiotropic drug resistance-like subfamily G of ATP-binding cassette ...

22-220

4.95e-13

First domain of the pleiotropic drug resistance-like subfamily G of ATP-binding cassette transporters; The pleiotropic drug resistance (PDR) is a well-described phenomenon occurring in fungi and shares several similarities with processes in bacteria and higher eukaryotes. This PDR subfamily represents domain I of its (ABC-IM)2 organization. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213200 [Multi-domain] Cd Length: 202 Bit Score: 67.29 E-value: 4.95e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  22 VDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTG---GTILINGEDtSALDTVSLRRKIGYVIQQIGLFPNMTIE 98
Cdd:cd03233   23 LKDFSGVVKPGEMVLVLGRPGSGCSTLLKALANRTEGNVsveGDIHYNGIP-YKEFAEKYPGEIIYVSEEDVHFPTLTVR 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  99 ENITVVPRMLGwdkkrcharaeelmsmvaldpkrflHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRET 178
Cdd:cd03233  102 ETLDFALRCKG-------------------------NEFVRGISGGERKRVSIAEALVSRASVLCWDNSTRGLDSSTALE 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 727180512 179 IQNEFLDMQRQLKKTVML-VSHDIDEALKLGDRIAVFRQGKIV 220
Cdd:cd03233  157 ILKCIRTMADVLKTTTFVsLYQASDEIYDLFDKVLVLYEGRQI 199

PRK13538

cytochrome c biogenesis heme-transporting ATPase CcmA;

23-172

5.80e-13

cytochrome c biogenesis heme-transporting ATPase CcmA;

Pssm-ID: 184125 [Multi-domain] Cd Length: 204 Bit Score: 67.14 E-value: 5.80e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  23 DNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTvSLRRKIGYVIQQIGLFPNMTIEENIT 102
Cdd:PRK13538  18 SGLSFTLNAGELVQIEGPNGAGKTSLLRILAGLARPDAGEVLWQGEPIRRQRD-EYHQDLLYLGHQPGIKTELTALENLR 96

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727180512 103 VVPRMlgwdkkrcHARAEELMSMVALDP---KRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVD 172
Cdd:PRK13538  97 FYQRL--------HGPGDDEALWEALAQvglAGFEDVPVRQLSAGQQRRVALARLWLTRAPLWILDEPFTAID 161

YddA

COG4178

ABC-type uncharacterized transport system, permease and ATPase components [General function ...

1-199

9.30e-13

ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only];

Pssm-ID: 443337 [Multi-domain] Cd Length: 571 Bit Score: 69.45 E-value: 9.30e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTkqFMQKNGTPFnaVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSA-------L 73
Cdd:COG4178  362 ALALEDLT--LRTPDGRPL--LEDLSLSLKPGERLLITGPSGSGKSTLLRAIAGLWPYGSGRIARPAGARVLflpqrpyL 437

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  74 DTVSLRrkigyviQQIgLFPNmtIEENITvvprmlgwdkkrcHARAEELMSMVALDpkRFLHRY------PKEMSGGQQQ 147
Cdd:COG4178  438 PLGTLR-------EAL-LYPA--TAEAFS-------------DAELREALEAVGLG--HLAERLdeeadwDQVLSLGEQQ 492

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 727180512 148 RIGVIRALAADPPVLLMDEPFGAVDPINretiQNEFLDM-QRQLKK-TVMLVSH 199
Cdd:COG4178  493 RLAFARLLLHKPDWLFLDEATSALDEEN----EAALYQLlREELPGtTVISVGH 542

CFTR_protein

TIGR01271

cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis ...

16-244

1.09e-12

cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis fibrosis transmembrane conductor regulator (CFTR) in eukaryotes. The principal role of this protein is chloride ion conductance. The protein is predicted to consist of 12 transmembrane domains. Mutations or lesions in the genetic loci have been linked to the aetiology of asthma, bronchiectasis, chronic obstructive pulmonary disease etc. Disease-causing mutations have been studied by 36Cl efflux assays in vitro cell cultures and electrophysiology, all of which point to the impairment of chloride channel stability and not the biosynthetic processing per se. [Transport and binding proteins, Anions]

Pssm-ID: 273530 [Multi-domain] Cd Length: 1490 Bit Score: 69.55 E-value: 1.09e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512    16 GTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGedtsaldtvslrrKIGYVIQQIGLFPNm 95
Cdd:TIGR01271  438 VTP--VLKNISFKLEKGQLLAVAGSTGSGKSSLLMMIMGELEPSEGKIKHSG-------------RISFSPQTSWIMPG- 501

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512    96 TIEENITVvprMLGWDKKRCHA-----RAEELMSMVALDPKRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGA 170
Cdd:TIGR01271  502 TIKDNIIF---GLSYDEYRYTSvikacQLEEDIALFPEKDKTVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFTH 578

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727180512   171 VDPINRETIQNEFLdMQRQLKKTVMLVSHDIdEALKLGDRIAVFRQGKIVQNASADELLA-RPanEFVASFVGQD 244
Cdd:TIGR01271  579 LDVVTEKEIFESCL-CKLMSNKTRILVTSKL-EHLKKADKILLLHEGVCYFYGTFSELQAkRP--DFSSLLLGLE 649

hmuV

PRK13547

heme ABC transporter ATP-binding protein;

22-233

1.33e-12

heme ABC transporter ATP-binding protein;

Pssm-ID: 184132 [Multi-domain] Cd Length: 272 Bit Score: 67.16 E-value: 1.33e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  22 VDNINLDVPEGEICVLLGPSGCGKTTTLKMI-NRLIEPTG-------GTILINGEDTSALDTVSLRRKIGYVIQQ----- 88
Cdd:PRK13547  17 LRDLSLRIEPGRVTALLGRNGAGKSTLLKALaGDLTGGGAprgarvtGDVTLNGEPLAAIDAPRLARLRAVLPQAaqpaf 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  89 ---------IGLFPNMTIEENITVVPRMLGWdkkrchaRAEELMSMVALDpkrflHRYPKEMSGGQQQRIGVIRALA--- 156
Cdd:PRK13547  97 afsareivlLGRYPHARRAGALTHRDGEIAW-------QALALAGATALV-----GRDVTTLSGGELARVQFARVLAqlw 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 157 ------ADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLa 230
Cdd:PRK13547 165 pphdaaQPPRYLLLDEPTAALDLAHQHRLLDTVRRLARDWNLGVLAIVHDPNLAARHADRIAMLADGAIVAHGAPADVL- 243


                 ...
gi 727180512 231 RPA 233
Cdd:PRK13547 244 TPA 246

ABCC_CFTR1

cd03291

ATP-binding cassette domain of the cystic fibrosis transmembrane regulator, subfamily C; The ...

24-244

1.68e-12

ATP-binding cassette domain of the cystic fibrosis transmembrane regulator, subfamily C; The CFTR subfamily domain 1. The cystic fibrosis transmembrane regulator (CFTR), the product of the gene mutated in patients with cystic fibrosis, has adapted the ABC transporter structural motif to form a tightly regulated anion channel at the apical surface of many epithelia. Use of the term assembly of a functional ion channel implies the coming together of subunits, or at least smaller not-yet functional components of the active whole. In fact, on the basis of current knowledge only the CFTR polypeptide itself is required to form an ATP- and protein kinase A-dependent low-conductance chloride channel of the type present in the apical membrane of many epithelial cells. CFTR displays the typical organization (IM-ABC)2 and carries a characteristic hydrophilic R-domain that separates IM1-ABC1 from IM2-ABC2.

Pssm-ID: 213258 [Multi-domain] Cd Length: 282 Bit Score: 67.19 E-value: 1.68e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  24 NINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGedtsaldtvslrrKIGYVIQQIGLFPNmTIEENITV 103
Cdd:cd03291   55 NINLKIEKGEMLAITGSTGSGKTSLLMLILGELEPSEGKIKHSG-------------RISFSSQFSWIMPG-TIKENIIF 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 104 vprMLGWDKKRCHA-----RAEELMSMVALDPKRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRET 178
Cdd:cd03291  121 ---GVSYDEYRYKSvvkacQLEEDITKFPEKDNTVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVFTEKE 197

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 727180512 179 IQNEFLdMQRQLKKTVMLVSHDIdEALKLGDRIAVFRQGKIVQNASADELLA-RPanEFVASFVGQD 244
Cdd:cd03291  198 IFESCV-CKLMANKTRILVTSKM-EHLKKADKILILHEGSSYFYGTFSELQSlRP--DFSSKLMGYD 260

araG

PRK11288

L-arabinose ABC transporter ATP-binding protein AraG;

25-235

2.42e-12

L-arabinose ABC transporter ATP-binding protein AraG;

Pssm-ID: 183077 [Multi-domain] Cd Length: 501 Bit Score: 68.01 E-value: 2.42e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  25 INLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEdtsaldTVSLRRKIGYVIQQI----------GLFPN 94
Cdd:PRK11288 272 ISFSVRAGEIVGLFGLVGAGRSELMKLLYGATRRTAGQVYLDGK------PIDIRSPRDAIRAGImlcpedrkaeGIIPV 345

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  95 MTIEENITVVPRmlgwdkkRCHARAEELmsmvaLDPKR---FLHRYPKEM--------------SGGQQQRIGVIRALAA 157
Cdd:PRK11288 346 HSVADNINISAR-------RHHLRAGCL-----INNRWeaeNADRFIRSLniktpsreqlimnlSGGNQQKAILGRWLSE 413

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727180512 158 DPPVLLMDEPFGAVDPINRETIQNEFLDMQRQlKKTVMLVSHDIDEALKLGDRIAVFRQGKIvqnasADELLARPANE 235
Cdd:PRK11288 414 DMKVILLDEPTRGIDVGAKHEIYNVIYELAAQ-GVAVLFVSSDLPEVLGVADRIVVMREGRI-----AGELAREQATE 485

PRK10762

D-ribose transporter ATP binding protein; Provisional

22-230

5.37e-12

D-ribose transporter ATP binding protein; Provisional

Pssm-ID: 236755 [Multi-domain] Cd Length: 501 Bit Score: 66.95 E-value: 5.37e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  22 VDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDtsaLDTVS----LRRKIGYVIQQI---GLFPN 94
Cdd:PRK10762 268 VNDVSFTLRKGEILGVSGLMGAGRTELMKVLYGALPRTSGYVTLDGHE---VVTRSpqdgLANGIVYISEDRkrdGLVLG 344

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  95 MTIEENITVvPRMLGWDKKRCHARAEELMSMVALDPKRFLHRYP------KEMSGGQQQRIGVIRALAADPPVLLMDEPF 168
Cdd:PRK10762 345 MSVKENMSL-TALRYFSRAGGSLKHADEQQAVSDFIRLFNIKTPsmeqaiGLLSGGNQQKVAIARGLMTRPKVLILDEPT 423

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 169 GAVD-PINRETIQ--NEFldmqRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKI-----VQNASADELLA 230
Cdd:PRK10762 424 RGVDvGAKKEIYQliNQF----KAEGLSIILVSSEMPEVLGMSDRILVMHEGRIsgeftREQATQEKLMA 489

ABC_FeS_Assembly

cd03217

ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Biosynthesis of ...

22-229

6.26e-12

ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Biosynthesis of iron-sulfur clusters (Fe-S) depends on multi-protein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under stressful conditions. The SUF system is made of six proteins: SufC is an atypical cytoplasmic ABC-ATPase, which forms a complex with SufB and SufD; SufA plays the role of a scaffold protein for assembly of iron-sulfur clusters and delivery to target proteins; SufS is a cysteine desulfurase which mobilizes the sulfur atom from cysteine and provides it to the cluster; SufE has no associated function yet.

Pssm-ID: 213184 [Multi-domain] Cd Length: 200 Bit Score: 64.09 E-value: 6.26e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  22 VDNINLDVPEGEICVLLGPSGCGKTTTLKMI--NRLIEPTGGTILINGEDTSALdTVSLRRKIGyviqqIGLFPNMTIEe 99
Cdd:cd03217   16 LKGVNLTIKKGEVHALMGPNGSGKSTLAKTImgHPKYEVTEGEILFKGEDITDL-PPEERARLG-----IFLAFQYPPE- 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 100 nitvvprmlgwdkkrcharaeelMSMVALdpKRFLhRYPKE-MSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRET 178
Cdd:cd03217   89 -----------------------IPGVKN--ADFL-RYVNEgFSGGEKKRNEILQLLLLEPDLAILDEPDSGLDIDALRL 142

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 727180512 179 IQNEFLDMqRQLKKTVMLVSH--DIDEALKlGDRIAVFRQGKIVQNASADELL 229
Cdd:cd03217  143 VAEVINKL-REEGKSVLIITHyqRLLDYIK-PDRVHVLYDGRIVKSGDKELAL 193

PLN03211

ABC transporter G-25; Provisional

32-172

2.88e-11

ABC transporter G-25; Provisional

Pssm-ID: 215634 [Multi-domain] Cd Length: 659 Bit Score: 64.90 E-value: 2.88e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  32 GEICVLLGPSGCGKTTTLKMINRLIEPTG--GTILINGEDTsaldTVSLRRKIGYVIQQIGLFPNMTIEENITVV----- 104
Cdd:PLN03211  94 GEILAVLGPSGSGKSTLLNALAGRIQGNNftGTILANNRKP----TKQILKRTGFVTQDDILYPHLTVRETLVFCsllrl 169

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727180512 105 PRMLGWDKKRchARAEELMSMVAL---DPKRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVD 172
Cdd:PLN03211 170 PKSLTKQEKI--LVAESVISELGLtkcENTIIGNSFIRGISGGERKRVSIAHEMLINPSLLILDEPTSGLD 238

PRK13409

ribosome biogenesis/translation initiation ATPase RLI;

31-214

6.46e-11

ribosome biogenesis/translation initiation ATPase RLI;

Pssm-ID: 184037 [Multi-domain] Cd Length: 590 Bit Score: 63.67 E-value: 6.46e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  31 EGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINgedtsaldtvslrRKIGYVIQQIGLFPNMTIEENITVVPRMLG- 109
Cdd:PRK13409 364 EGEVIGIVGPNGIGKTTFAKLLAGVLKPDEGEVDPE-------------LKISYKPQYIKPDYDGTVEDLLRSITDDLGs 430

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 110 -WDKkrcharaEELMSMVALDpkRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPfgavdpinretiqNEFLDMQR 188
Cdd:PRK13409 431 sYYK-------SEIIKPLQLE--RLLDKNVKDLSGGELQRVAIAACLSRDADLYLLDEP-------------SAHLDVEQ 488

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 727180512 189 QL-------------KKTVMLVSHDI---DealKLGDRIAVF 214
Cdd:PRK13409 489 RLavakairriaeerEATALVVDHDIymiD---YISDRLMVF 527

PLN03130

ABC transporter C family member; Provisional

24-230

7.30e-11

ABC transporter C family member; Provisional

Pssm-ID: 215595 [Multi-domain] Cd Length: 1622 Bit Score: 63.99 E-value: 7.30e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   24 NINLDVPEGEICVLLGPSGCGKTTTLK-MINRLIEPTGGTILINGedtsaldtvslrrKIGYVIQQIGLFpNMTIEENIt 102
Cdd:PLN03130  635 NINLDVPVGSLVAIVGSTGEGKTSLISaMLGELPPRSDASVVIRG-------------TVAYVPQVSWIF-NATVRDNI- 699

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  103 vvprMLGWDKKRchARAEELMSMVALDpkRFLHRYPK-----------EMSGGQQQRIGVIRALAADPPVLLMDEPFGAV 171
Cdd:PLN03130  700 ----LFGSPFDP--ERYERAIDVTALQ--HDLDLLPGgdlteigergvNISGGQKQRVSMARAVYSNSDVYIFDDPLSAL 771

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  172 DP-INRETIQNEFLDMQRQlkKTVMLVSHDIdEALKLGDRIAVFRQGKIVQNASADELLA 230
Cdd:PLN03130  772 DAhVGRQVFDKCIKDELRG--KTRVLVTNQL-HFLSQVDRIILVHEGMIKEEGTYEELSN 828

CBS_pair_arch

cd09836

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains; The CBS domain, ...

265-368

8.37e-11

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).

Pssm-ID: 341405 [Multi-domain] Cd Length: 116 Bit Score: 58.69 E-value: 8.37e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 265 VTVRRETPLVEAFGLMDDIDARSVTVVDADGKPLGYVKRRE-----ARGAPGVCADSLHRFR--VTARAEENLRVVLSKL 337
Cdd:cd09836    6 VTVPPETTIREAAKLMAENNIGSVVVVDDDGKPVGIVTERDivravAEGIDLDTPVEEIMTKnlVTVSPDESIYEAAELM 85

                         90       100       110
                 ....*....|....*....|....*....|.
gi 727180512 338 YEHNTSWMPIVDEDGRYSGEISQDYIADYLS 368
Cdd:cd09836   86 REHNIRHLPVVDGGGKLVGVISIRDLARELS 116

PLN03232

ABC transporter C family member; Provisional

37-236

9.51e-11

ABC transporter C family member; Provisional

Pssm-ID: 215640 [Multi-domain] Cd Length: 1495 Bit Score: 63.84 E-value: 9.51e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   37 LLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRKIGYVIQQIGLFPNmTIEENITVVPRMLG---WDK- 112
Cdd:PLN03232 1267 VVGRTGAGKSSMLNALFRIVELEKGRIMIDDCDVAKFGLTDLRRVLSIIPQSPVLFSG-TVRFNIDPFSEHNDadlWEAl 1345

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  113 KRCHARAEELMSMVALDPKRFlhRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAV----DPINRETIQNEFLDMqr 188
Cdd:PLN03232 1346 ERAHIKDVIDRNPFGLDAEVS--EGGENFSVGQRQLLSLARALLRRSKILVLDEATASVdvrtDSLIQRTIREEFKSC-- 1421

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 727180512  189 qlkkTVMLVSHDIDEALKLgDRIAVFRQGKIVQNASADELLARPANEF 236
Cdd:PLN03232 1422 ----TMLVIAHRLNTIIDC-DKILVLSSGQVLEYDSPQELLSRDTSAF 1464

COG3448

CBS-domain-containing membrane protein [Signal transduction mechanisms];

265-367

1.66e-10

CBS-domain-containing membrane protein [Signal transduction mechanisms];

Pssm-ID: 442671 [Multi-domain] Cd Length: 136 Bit Score: 58.34 E-value: 1.66e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 265 VTVRRETPLVEAFGLMDDIDARSVTVVDADGKPLGYV-----KRREARGAPGVCADSLHRFRV---------TARAEENL 330
Cdd:COG3448   13 VTVSPDTTLREALELMREHGIRGLPVVDEDGRLVGIVterdlLRALLPDRLDELEERLLDLPVedvmtrpvvTVTPDTPL 92

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 727180512 331 RVVLSKLYEHNTSWMPIVDEDGRYSGEISQDYIADYL 367
Cdd:COG3448   93 EEAAELMLEHGIHRLPVVDDDGRLVGIVTRTDLLRAL 129

PLN03232

ABC transporter C family member; Provisional

24-266

1.66e-10

ABC transporter C family member; Provisional

Pssm-ID: 215640 [Multi-domain] Cd Length: 1495 Bit Score: 63.07 E-value: 1.66e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   24 NINLDVPEGEICVLLGPSGCGKTTtlkminrLIEPTGGTiLINGEDTSaldtVSLRRKIGYVIQQIGLFpNMTIEENItv 103
Cdd:PLN03232  635 DINLEIPVGSLVAIVGGTGEGKTS-------LISAMLGE-LSHAETSS----VVIRGSVAYVPQVSWIF-NATVRENI-- 699

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  104 vprMLGWD-KKRCHARAEELMSM---VALDPKRFLHRYPKE---MSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPinr 176
Cdd:PLN03232  700 ---LFGSDfESERYWRAIDVTALqhdLDLLPGRDLTEIGERgvnISGGQKQRVSMARAVYSNSDIYIFDDPLSALDA--- 773

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  177 eTIQNEFLD--MQRQLK-KTVMLVSHDIdEALKLGDRIAVFRQGKIVQNASADELlarpanefvasfvGQDRTLKRLLLV 253
Cdd:PLN03232  774 -HVAHQVFDscMKDELKgKTRVLVTNQL-HFLPLMDRIILVSEGMIKEEGTFAEL-------------SKSGSLFKKLME 838

                         250
                  ....*....|...
gi 727180512  254 QAGDVAGQQETVT 266
Cdd:PLN03232  839 NAGKMDATQEVNT 851

xylG

TIGR02633

D-xylose ABC transporter, ATP-binding protein; Several bacterial species have enzymes xylose ...

22-228

1.99e-10

Pssm-ID: 131681 [Multi-domain] Cd Length: 500 Bit Score: 62.15 E-value: 1.99e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   22 VDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPT-GGTILINGEDTSALDTV-SLRRKIGYVIQ---QIGLFPNMT 96
Cdd:TIGR02633 276 VDDVSFSLRRGEILGVAGLVGAGRTELVQALFGAYPGKfEGNVFINGKPVDIRNPAqAIRAGIAMVPEdrkRHGIVPILG 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   97 IEENITVVPRMLGWDKKRCHARAEE---LMSMVALDPKRFLHRYP-KEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVD 172
Cdd:TIGR02633 356 VGKNITLSVLKSFCFKMRIDAAAELqiiGSAIQRLKVKTASPFLPiGRLSGGNQQKAVLAKMLLTNPRVLILDEPTRGVD 435

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 727180512  173 PINRETIQnEFLDMQRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADEL 228
Cdd:TIGR02633 436 VGAKYEIY-KLINQLAQEGVAIIVVSSELAEVLGLSDRVLVIGEGKLKGDFVNHAL 490

AAA

smart00382

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...

32-216

3.18e-10

Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 58.15 E-value: 3.18e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512    32 GEICVLLGPSGCGKTTTLKMINRLIEPTGGT-ILINGEDTSALDTVSLRRKIGyviqqiglfpnmtieenitvvprmlgw 110
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPGGGvIYIDGEDILEEVLDQLLLIIV--------------------------- 54

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   111 dkkrcharaeelmsmvaldpkrflHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRETIQ-----NEFLD 185
Cdd:smart00382  55 ------------------------GGKKASGSGELRLRLALALARKLKPDVLILDEITSLLDAEQEALLLlleelRLLLL 110

                          170       180       190
                   ....*....|....*....|....*....|.
gi 727180512   186 MQRQLKKTVMLVSHDIDEALKLGDRIAVFRQ 216
Cdd:smart00382 111 LKSEKNLTVILTTNDEKDLGPALLRRRFDRR 141

CBS

COG0517

CBS domain [Signal transduction mechanisms];

265-367

3.82e-10

CBS domain [Signal transduction mechanisms];

Pssm-ID: 440283 [Multi-domain] Cd Length: 128 Bit Score: 57.18 E-value: 3.82e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 265 VTVRRETPLVEAFGLMDDIDARSVTVVDADGKPLGYVKRREARGAPGVCADSLHRFRV---------TARAEENLRVVLS 335
Cdd:COG0517   12 VTVSPDATVREALELMSEKRIGGLPVVDEDGKLVGIVTDRDLRRALAAEGKDLLDTPVsevmtrppvTVSPDTSLEEAAE 91

                         90       100       110
                 ....*....|....*....|....*....|..
gi 727180512 336 KLYEHNTSWMPIVDEDGRYSGEISQDYIADYL 367
Cdd:COG0517   92 LMEEHKIRRLPVVDDDGRLVGIITIKDLLKAL 123

PRK13543

heme ABC exporter ATP-binding protein CcmA;

32-173

3.82e-10

heme ABC exporter ATP-binding protein CcmA;

Pssm-ID: 184129 [Multi-domain] Cd Length: 214 Bit Score: 59.09 E-value: 3.82e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  32 GEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVslrRKIGYVIQQIGLFPNMTIEENITVVPRMLGWD 111
Cdd:PRK13543  37 GEALLVQGDNGAGKTTLLRVLAGLLHVESGQIQIDGKTATRGDRS---RFMAYLGHLPGLKADLSTLENLHFLCGLHGRR 113

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727180512 112 KKRCHARAeelMSMVAL-DPKRFLHRypkEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDP 173
Cdd:PRK13543 114 AKQMPGSA---LAIVGLaGYEDTLVR---QLSAGQKKRLALARLWLSPAPLWLLDEPYANLDL 170

PRK10790

SmdB family multidrug efflux ABC transporter permease/ATP-binding protein;

2-231

8.09e-10

SmdB family multidrug efflux ABC transporter permease/ATP-binding protein;

Pssm-ID: 182733 [Multi-domain] Cd Length: 592 Bit Score: 60.50 E-value: 8.09e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTkqFMQKNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRK 81
Cdd:PRK10790 341 IDIDNVS--FAYRDDNL--VLQNINLSVPSRGFVALVGHTGSGKSTLASLLMGYYPLTEGEIRLDGRPLSSLSHSVLRQG 416

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQI-----GLFPNMTIEENITvvprmlgwdkkrcHARAEELMSMVALDPkrFLHRYPK-----------EMSGGQ 145
Cdd:PRK10790 417 VAMVQQDPvvladTFLANVTLGRDIS-------------EEQVWQALETVQLAE--LARSLPDglytplgeqgnNLSVGQ 481

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 146 QQRIGVIRALAADPPVLLMDEPFGAVDPINRETIQNEfLDMQRQlKKTVMLVSH---DIDEAlklgDRIAVFRQGKIVQN 222
Cdd:PRK10790 482 KQLLALARVLVQTPQILILDEATANIDSGTEQAIQQA-LAAVRE-HTTLVVIAHrlsTIVEA----DTILVLHRGQAVEQ 555


                 ....*....
gi 727180512 223 ASADELLAR 231
Cdd:PRK10790 556 GTHQQLLAA 564

CBS_pair_bact_arch

cd17775

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in bacteria ...

262-367

1.02e-09

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in bacteria and archaea; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).

Pssm-ID: 341411 [Multi-domain] Cd Length: 117 Bit Score: 55.63 E-value: 1.02e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 262 QETVTVRRETPLVEAFGLMDDIDARSVTVVDADGKPLGYVKRRE---ARGAPGVCADSL------HRFRVTARAEENLRV 332
Cdd:cd17775    3 REVVTASPDTSVLEAARLMRDHHVGSVVVVEEDGKPVGIVTDRDivvEVVAKGLDPKDVtvgdimSADLITAREDDGLFE 82

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 727180512 333 VLSKLYEHNTSWMPIVDEDGRYSGEISQDYIADYL 367
Cdd:cd17775   83 ALERMREKGVRRLPVVDDDGELVGIVTLDDILELL 117

Rli1

COG1245

Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ...

31-214

1.15e-09

Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis];

Pssm-ID: 440858 [Multi-domain] Cd Length: 592 Bit Score: 59.80 E-value: 1.15e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  31 EGEICVLLGPSGCGKTTTLKMINRLIEPTGGtilingedtsaldTVSLRRKIGYVIQQIGLFPNMTIEENI-TVVPRMLG 109
Cdd:COG1245  365 EGEVLGIVGPNGIGKTTFAKILAGVLKPDEG-------------EVDEDLKISYKPQYISPDYDGTVEEFLrSANTDDFG 431

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 110 --WDKkrcharaEELMSMVALDpkRFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINR----ETIQNef 183
Cdd:COG1245  432 ssYYK-------TEIIKPLGLE--KLLDKNVKDLSGGELQRVAIAACLSRDADLYLLDEPSAHLDVEQRlavaKAIRR-- 500

                        170       180       190
                 ....*....|....*....|....*....|....
gi 727180512 184 ldMQRQLKKTVMLVSHDI---DealKLGDRIAVF 214
Cdd:COG1245  501 --FAENRGKTAMVVDHDIyliD---YISDRLMVF 529

ABC_ABC_ChvD

TIGR03719

ATP-binding cassette protein, ChvD family; Members of this protein family have two copies of ...

2-167

1.19e-09

ATP-binding cassette protein, ChvD family; Members of this protein family have two copies of the ABC transporter ATP-binding cassette, but are found outside the common ABC transporter operon structure that features integral membrane permease proteins and substrate-binding proteins encoded next to the ATP-binding cassette (ABC domain) protein. The member protein ChvD from Agrobacterium tumefaciens was identified as both a candidate to interact with VirB8, based on yeast two-hybrid analysis, and as an apparent regulator of VirG. The general function of this protein family is unknown.

Pssm-ID: 274744 [Multi-domain] Cd Length: 552 Bit Score: 59.56 E-value: 1.19e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512    2 IKLENLTKQFMQKNgtpfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINgedtsalDTVslrrK 81
Cdd:TIGR03719 323 IEAENLTKAFGDKL-----LIDDLSFKLPPGGIVGVIGPNGAGKSTLFRMITGQEQPDSGTIEIG-------ETV----K 386

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   82 IGYVIQQ-IGLFPNMTIEENITVVPRMLGWDKKRCHARAeelmsMVAldpkRF------LHRYPKEMSGGQQQRIGVIRA 154
Cdd:TIGR03719 387 LAYVDQSrDALDPNKTVWEEISGGLDIIKLGKREIPSRA-----YVG----RFnfkgsdQQKKVGQLSGGERNRVHLAKT 457

                         170
                  ....*....|...
gi 727180512  155 LAADPPVLLMDEP 167
Cdd:TIGR03719 458 LKSGGNVLLLDEP 470

ABCC_CFTR2

cd03289

ATP-binding cassette domain 2 of CFTR,subfamily C; The cystic fibrosis transmembrane regulator ...

2-229

1.88e-09

ATP-binding cassette domain 2 of CFTR,subfamily C; The cystic fibrosis transmembrane regulator (CFTR), the product of the gene mutated in patients with cystic fibrosis, has adapted the ABC transporter structural motif to form a tightly regulated anion channel at the apical surface of many epithelia. Use of the term assembly of a functional ion channel implies the coming together of subunits or at least smaller not-yet functional components of the active whole. In fact, on the basis of current knowledge only the CFTR polypeptide itself is required to form an ATP- and protein kinase A-dependent low-conductance chloride channel of the type present in the apical membrane of many epithelial cells. CFTR displays the typical organization (IM-ABC)2 and carries a characteristic hydrophilic R-domain that separates IM1-ABC1 from IM2-ABC2.

Pssm-ID: 213256 [Multi-domain] Cd Length: 275 Bit Score: 57.94 E-value: 1.88e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFMQKNgtpfNAV-DNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEpTGGTILINGEDTSALDTVSLRR 80
Cdd:cd03289    3 MTVKDLTAKYTEGG----NAVlENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEGDIQIDGVSWNSVPLQKWRK 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQQIGLFPNmTIEENItvvprmlgwDKKRCHARAEELMSMVALDPKRFLHRYPKEM-----------SGGQQQRI 149
Cdd:cd03289   78 AFGVIPQKVFIFSG-TFRKNL---------DPYGKWSDEEIWKVAEEVGLKSVIEQFPGQLdfvlvdggcvlSHGHKQLM 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 150 GVIRALAADPPVLLMDEPFGAVDPIN----RETIQNEFLDMqrqlkkTVMLVSHDIdEALKLGDRIAVFRQGKIVQNASA 225
Cdd:cd03289  148 CLARSVLSKAKILLLDEPSAHLDPITyqviRKTLKQAFADC------TVILSEHRI-EAMLECQRFLVIEENKVRQYDSI 220


                 ....
gi 727180512 226 DELL 229
Cdd:cd03289  221 QKLL 224

ABCG_PDR_domain2

cd03232

Second domain of the pleiotropic drug resistance-like (PDR) subfamily G of ATP-binding ...

23-167

2.09e-09

Second domain of the pleiotropic drug resistance-like (PDR) subfamily G of ATP-binding cassette transporters; The pleiotropic drug resistance (PDR) is a well-described phenomenon occurring in fungi and shares several similarities with processes in bacteria and higher eukaryotes. This PDR subfamily represents domain I of its (ABC-IM)2 organization. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213199 [Multi-domain] Cd Length: 192 Bit Score: 56.48 E-value: 2.09e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  23 DNINLDVPEGEICVLLGPSGCGKTTTLKMI-NRLIEPT-GGTILINGEdtsaLDTVSLRRKIGYVIQQIGLFPNMTIEEN 100
Cdd:cd03232   24 NNISGYVKPGTLTALMGESGAGKTTLLDVLaGRKTAGViTGEILINGR----PLDKNFQRSTGYVEQQDVHSPNLTVREA 99

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 727180512 101 ItvvprmlgwdkkrcharaeelmsmvaldpkRFlHRYPKEMSGGQQQR--IGVirALAADPPVLLMDEP 167
Cdd:cd03232  100 L------------------------------RF-SALLRGLSVEQRKRltIGV--ELAAKPSILFLDEP 135

ycf16

CHL00131

sulfate ABC transporter protein; Validated

24-226

3.70e-09

sulfate ABC transporter protein; Validated

Pssm-ID: 214372 [Multi-domain] Cd Length: 252 Bit Score: 56.96 E-value: 3.70e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  24 NINLDVPEGEICVLLGPSGCGKTTTLKMI--NRLIEPTGGTILINGEDTSALDTvSLRRKIG------YVIQqiglFPNM 95
Cdd:CHL00131  25 GLNLSINKGEIHAIMGPNGSGKSTLSKVIagHPAYKILEGDILFKGESILDLEP-EERAHLGiflafqYPIE----IPGV 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  96 TIEENItvvprMLGWDKKRCHARAEEL------------MSMVALDPKrFLHRYPKE-MSGGQQQRIGVIRALAADPPVL 162
Cdd:CHL00131 100 SNADFL-----RLAYNSKRKFQGLPELdplefleiinekLKLVGMDPS-FLSRNVNEgFSGGEKKRNEILQMALLDSELA 173

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727180512 163 LMDEPFGAVDpINRETIQNEFLDMQRQLKKTVMLVSH--DIDEALKlGDRIAVFRQGKIVQNASAD 226
Cdd:CHL00131 174 ILDETDSGLD-IDALKIIAEGINKLMTSENSIILITHyqRLLDYIK-PDYVHVMQNGKIIKTGDAE 237

PRK10982

galactose/methyl galaxtoside transporter ATP-binding protein; Provisional

21-246

6.87e-09

galactose/methyl galaxtoside transporter ATP-binding protein; Provisional

Pssm-ID: 182880 [Multi-domain] Cd Length: 491 Bit Score: 57.43 E-value: 6.87e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  21 AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTV-SLRRKIGYVIQQIGLFPNMTIEE 99
Cdd:PRK10982  13 ALDNVNLKVRPHSIHALMGENGAGKSTLLKCLFGIYQKDSGSILFQGKEIDFKSSKeALENGISMVHQELNLVLQRSVMD 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 100 NITV--VPRMlGW--DKKRCHARAEELMSM--VALDPKRFLhrypKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDp 173
Cdd:PRK10982  93 NMWLgrYPTK-GMfvDQDKMYRDTKAIFDEldIDIDPRAKV----ATLSVSQMQMIEIAKAFSYNAKIVIMDEPTSSLT- 166

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727180512 174 inrETIQNEFLDMQRQLKKT---VMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELlarPANEFVASFVGQDRT 246
Cdd:PRK10982 167 ---EKEVNHLFTIIRKLKERgcgIVYISHKMEEIFQLCDEITILRDGQWIATQPLAGL---TMDKIIAMMVGRSLT 236

PLN03130

ABC transporter C family member; Provisional

37-236

8.74e-09

ABC transporter C family member; Provisional

Pssm-ID: 215595 [Multi-domain] Cd Length: 1622 Bit Score: 57.44 E-value: 8.74e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   37 LLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRKIGYVIQQIGLFPNmTIEENItvvprmlgwDKKRCH 116
Cdd:PLN03130 1270 IVGRTGAGKSSMLNALFRIVELERGRILIDGCDISKFGLMDLRKVLGIIPQAPVLFSG-TVRFNL---------DPFNEH 1339

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  117 ARAEELMSMVALDPKRFLHRYPKEM-----------SGGQQQRIGVIRALAADPPVLLMDEPFGAV----DPINRETIQN 181
Cdd:PLN03130 1340 NDADLWESLERAHLKDVIRRNSLGLdaevseagenfSVGQRQLLSLARALLRRSKILVLDEATAAVdvrtDALIQKTIRE 1419

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 727180512  182 EFldmqrqlKKTVMLV-SHDIDEALKLgDRIAVFRQGKIVQNASADELLARPANEF 236
Cdd:PLN03130 1420 EF-------KSCTMLIiAHRLNTIIDC-DRILVLDAGRVVEFDTPENLLSNEGSAF 1467

CFTR_protein

TIGR01271

cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis ...

4-229

1.16e-08

Pssm-ID: 273530 [Multi-domain] Cd Length: 1490 Bit Score: 57.23 E-value: 1.16e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512     4 LENLTKQFMQKNgtpfNAV-DNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEpTGGTILINGEDTSALDTVSLRRKI 82
Cdd:TIGR01271 1220 VQGLTAKYTEAG----RAVlQDLSFSVEGGQRVGLLGRTGSGKSTLLSALLRLLS-TEGEIQIDGVSWNSVTLQTWRKAF 1294

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512    83 GYVIQQIGLFPNmTIEENITVVPRmlgWDKKRCHARAEE--LMSMVALDPKRF---LHRYPKEMSGGQQQRIGVIRALAA 157
Cdd:TIGR01271 1295 GVIPQKVFIFSG-TFRKNLDPYEQ---WSDEEIWKVAEEvgLKSVIEQFPDKLdfvLVDGGYVLSNGHKQLMCLARSILS 1370

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727180512   158 DPPVLLMDEPFGAVDPIN----RETIQNEFLDMqrqlkkTVMLVSHDIdEALKLGDRIAVFRQGKIVQNASADELL 229
Cdd:TIGR01271 1371 KAKILLLDEPSAHLDPVTlqiiRKTLKQSFSNC------TVILSEHRV-EALLECQQFLVIEGSSVKQYDSIQKLL 1439

PRK15064

ABC transporter ATP-binding protein; Provisional

1-200

1.28e-08

ABC transporter ATP-binding protein; Provisional

Pssm-ID: 237894 [Multi-domain] Cd Length: 530 Bit Score: 56.44 E-value: 1.28e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQKngtPFnaVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILING------------- 67
Cdd:PRK15064   1 MLSTANITMQFGAK---PL--FENISVKFGGGNRYGLIGANGCGKSTFMKILGGDLEPSAGNVSLDPnerlgklrqdqfa 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  68 -EDTSALDTVSL-RRKIGYVIQQ---IGLFPNMTIEENITV------VPRMLGWDKKrchARAEELMSMVALDPKrfLHR 136
Cdd:PRK15064  76 fEEFTVLDTVIMgHTELWEVKQErdrIYALPEMSEEDGMKVadlevkFAEMDGYTAE---ARAGELLLGVGIPEE--QHY 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727180512 137 YP-KEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDpINreTIQneFL-DMQRQLKKTVMLVSHD 200
Cdd:PRK15064 151 GLmSEVAPGWKLRVLLAQALFSNPDILLLDEPTNNLD-IN--TIR--WLeDVLNERNSTMIIISHD 211

ABCC_SUR2

cd03288

ATP-binding cassette domain 2 of the sulfonylurea receptor SUR; The SUR domain 2. The ...

2-245

1.92e-08

ATP-binding cassette domain 2 of the sulfonylurea receptor SUR; The SUR domain 2. The sulfonylurea receptor SUR is an ATP binding cassette (ABC) protein of the ABCC/MRP family. Unlike other ABC proteins, it has no intrinsic transport function, neither active nor passive, but associates with the potassium channel proteins Kir6.1 or Kir6.2 to form the ATP-sensitive potassium (K(ATP)) channel. Within the channel complex, SUR serves as a regulatory subunit that fine-tunes the gating of Kir6.x in response to alterations in cellular metabolism. It constitutes a major pharmaceutical target as it binds numerous drugs, K(ATP) channel openers and blockers, capable of up- or down-regulating channel activity.

Pssm-ID: 213255 [Multi-domain] Cd Length: 257 Bit Score: 54.91 E-value: 1.92e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFmQKNGTPfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRK 81
Cdd:cd03288   20 IKIHDLCVRY-ENNLKP--VLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSR 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQIGLFPNmTIEENITvvPRMLGWDKKRCHA-RAEELMSMVALDP---KRFLHRYPKEMSGGQQQRIGVIRALAA 157
Cdd:cd03288   97 LSIILQDPILFSG-SIRFNLD--PECKCTDDRLWEAlEIAQLKNMVKSLPgglDAVVTEGGENFSVGQRQLFCLARAFVR 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 158 DPPVLLMDEPFGAVDPINRETIQNefLDMQRQLKKTVMLVSHDIDEALKlGDRIAVFRQGKIVQNASADELLARPANEFv 237
Cdd:cd03288  174 KSSILIMDEATASIDMATENILQK--VVMTAFADRTVVTIAHRVSTILD-ADLVLVLSRGILVECDTPENLLAQEDGVF- 249


                 ....*...
gi 727180512 238 ASFVGQDR 245
Cdd:cd03288  250 ASLVRTDK 257

PTZ00243

ABC transporter; Provisional

24-248

2.16e-08

ABC transporter; Provisional

Pssm-ID: 240327 [Multi-domain] Cd Length: 1560 Bit Score: 56.33 E-value: 2.16e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   24 NINLDVPEGEICVLLGPSGCGKTTTLkminrlieptgGTILINGEDTSAldTVSLRRKIGYVIQQIGLFpNMTIEENItv 103
Cdd:PTZ00243  678 DVSVSVPRGKLTVVLGATGSGKSTLL-----------QSLLSQFEISEG--RVWAERSIAYVPQQAWIM-NATVRGNI-- 741

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  104 vprmLGWDKKRCH-----ARAEELMSMVALDPKRfLHRYPKEM----SGGQQQRIGVIRALAADPPVLLMDEPFGAVDPI 174
Cdd:PTZ00243  742 ----LFFDEEDAArladaVRVSQLEADLAQLGGG-LETEIGEKgvnlSGGQKARVSLARAVYANRDVYLLDDPLSALDAH 816

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 727180512  175 NRETIQNEFLdMQRQLKKTVMLVSHDIdEALKLGDRIAVFRQGKIVQNASADELLARPANEFVASFVGQDRTLK 248
Cdd:PTZ00243  817 VGERVVEECF-LGALAGKTRVLATHQV-HVVPRADYVVALGDGRVEFSGSSADFMRTSLYATLAAELKENKDSK 888

ABC_RNaseL_inhibitor

cd03222

ATP-binding cassette domain of RNase L inhibitor; The ABC ATPase RNase L inhibitor (RLI) is a ...

28-240

2.89e-08

ATP-binding cassette domain of RNase L inhibitor; The ABC ATPase RNase L inhibitor (RLI) is a key enzyme in ribosomal biogenesis, formation of translation preinitiation complexes, and assembly of HIV capsids. RLI's are not transport proteins, and thus cluster with a group of soluble proteins that lack the transmembrane components commonly found in other members of the family. Structurally, RLI's have an N-terminal Fe-S domain and two nucleotide-binding domains, which are arranged to form two composite active sites in their interface cleft. RLI is one of the most conserved enzymes between archaea and eukaryotes with a sequence identity more than 48%. The high degree of evolutionary conservation suggests that RLI performs a central role in archaeal and eukaryotic physiology.

Pssm-ID: 213189 [Multi-domain] Cd Length: 177 Bit Score: 52.96 E-value: 2.89e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  28 DVPEGEICVLLGPSGCGKTTTLKMINRLIEPtggtiliNGEDTSaldtvslrrkigyviqqiglfpnmtieenitvvprm 107
Cdd:cd03222   21 VVKEGEVIGIVGPNGTGKTTAVKILAGQLIP-------NGDNDE------------------------------------ 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 108 lgWDKKRcharaeelmsmVALDPKRFlhrypkEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQ 187
Cdd:cd03222   58 --WDGIT-----------PVYKPQYI------DLSGGELQRVAIAAALLRNATFYLFDEPSAYLDIEQRLNAARAIRRLS 118

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 727180512 188 RQLKKTVMLVSHDIDEALKLGDRIAVFR-QGKIVQNASADELLARPANEFVASF 240
Cdd:cd03222  119 EEGKKTALVVEHDLAVLDYLSDRIHVFEgEPGVYGIASQPKGTREGINRFLRGY 172

PRK13541

cytochrome c biogenesis protein CcmA; Provisional

1-199

3.48e-08

cytochrome c biogenesis protein CcmA; Provisional

Pssm-ID: 184128 [Multi-domain] Cd Length: 195 Bit Score: 52.95 E-value: 3.48e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   1 MIKLENLTKQFMQKNgtpfnaVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLrr 80
Cdd:PRK13541   1 MLSLHQLQFNIEQKN------LFDLSITFLPSAITYIKGANGCGKSSLLRMIAGIMQPSSGNIYYKNCNINNIAKPYC-- 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 kiGYVIQQIGLFPNMTIEENITVvprmlgWDKkrCHARAEELMSMVA-LDPKRFLHRYPKEMSGGQQQRIGVIRALAADP 159
Cdd:PRK13541  73 --TYIGHNLGLKLEMTVFENLKF------WSE--IYNSAETLYAAIHyFKLHDLLDEKCYSLSSGMQKIVAIARLIACQS 142

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 727180512 160 PVLLMDEPFGAVDPINRETIQNeFLDMQRQLKKTVMLVSH 199
Cdd:PRK13541 143 DLWLLDEVETNLSKENRDLLNN-LIVMKANSGGIVLLSSH 181

PRK11819

putative ABC transporter ATP-binding protein; Reviewed

2-167

7.93e-08

putative ABC transporter ATP-binding protein; Reviewed

Pssm-ID: 236992 [Multi-domain] Cd Length: 556 Bit Score: 53.97 E-value: 7.93e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   2 IKLENLTKQFMQKNgtpfnAVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILInGEdtsaldTVslrrK 81
Cdd:PRK11819 325 IEAENLSKSFGDRL-----LIDDLSFSLPPGGIVGIIGPNGAGKSTLFKMITGQEQPDSGTIKI-GE------TV----K 388

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  82 IGYVIQQ-IGLFPNMTIEENIT----VVprMLGwdKKRCHARAeelmsMVAldpkRFLHRYP------KEMSGGQQQRIG 150
Cdd:PRK11819 389 LAYVDQSrDALDPNKTVWEEISggldII--KVG--NREIPSRA-----YVG----RFNFKGGdqqkkvGVLSGGERNRLH 455

                        170
                 ....*....|....*..
gi 727180512 151 VIRALAADPPVLLMDEP 167
Cdd:PRK11819 456 LAKTLKQGGNVLLLDEP 472

PRK15064

ABC transporter ATP-binding protein; Provisional

4-220

1.07e-07

ABC transporter ATP-binding protein; Provisional

Pssm-ID: 237894 [Multi-domain] Cd Length: 530 Bit Score: 53.74 E-value: 1.07e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   4 LENLTKQFmqKNGTPFNavdNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTIlingedtsaldTVSLRRKIG 83
Cdd:PRK15064 322 VENLTKGF--DNGPLFK---NLNLLLEAGERLAIIGENGVGKTTLLRTLVGELEPDSGTV-----------KWSENANIG 385

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  84 YVIQ--------QIGLFPNM----TIEENITVVPRMLGwdkkRCHARAEELMSMValdpkrflhrypKEMSGGQQQRIGV 151
Cdd:PRK15064 386 YYAQdhaydfenDLTLFDWMsqwrQEGDDEQAVRGTLG----RLLFSQDDIKKSV------------KVLSGGEKGRMLF 449

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727180512 152 IRALAADPPVLLMDEPFGAVDpinRETIQ--NEFLDMqrqLKKTVMLVSHDIDEALKLGDRIAVFRQGKIV 220
Cdd:PRK15064 450 GKLMMQKPNVLVMDEPTNHMD---MESIEslNMALEK---YEGTLIFVSHDREFVSSLATRIIEITPDGVV 514

COG2524

Predicted transcriptional regulator, contains C-terminal CBS domains [Transcription];

235-367

1.66e-07

Predicted transcriptional regulator, contains C-terminal CBS domains [Transcription];

Pssm-ID: 442013 [Multi-domain] Cd Length: 206 Bit Score: 51.42 E-value: 1.66e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 235 EFVASFVGQDRTLKRLLLVQAGDVAgQQETVTVRRETPLVEAFGLMDDIDARSVTVVDaDGKPLGYVKRREARGAPGVCA 314
Cdd:COG2524   68 QAAAVRVVAEKELGLVLKMKVKDIM-TKDVITVSPDTTLEEALELMLEKGISGLPVVD-DGKLVGIITERDLLKALAEGR 145

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727180512 315 DSLH--------RFRVTARAEENLRVVLSKLYEHNTSWMPIVDEDGRYSGEISQDYIADYL 367
Cdd:COG2524  146 DLLDapvsdimtRDVVTVSEDDSLEEALRLMLEHGIGRLPVVDDDGKLVGIITRTDILRAL 206

MRP_assoc_pro

TIGR00957

multi drug resistance-associated protein (MRP); This model describes multi drug ...

24-230

1.74e-07

Pssm-ID: 188098 [Multi-domain] Cd Length: 1522 Bit Score: 53.41 E-value: 1.74e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512    24 NINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGEDTSALDTVSLRRKIGYVIQQIGLFP---NMTIEEN 100
Cdd:TIGR00957 1304 HINVTIHGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGLNIAKIGLHDLRFKITIIPQDPVLFSgslRMNLDPF 1383

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   101 ITVVPRMLGWDKKRCHaraeeLMSMVALDPKRFLHRYP---KEMSGGQQQRIGVIRALAADPPVLLMDEPFGAV----DP 173
Cdd:TIGR00957 1384 SQYSDEEVWWALELAH-----LKTFVSALPDKLDHECAeggENLSVGQRQLVCLARALLRKTKILVLDEATAAVdletDN 1458

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 727180512   174 INRETIQNEFLDMqrqlkkTVMLVSHDIDEALKLgDRIAVFRQGKIVQNASADELLA 230
Cdd:TIGR00957 1459 LIQSTIRTQFEDC------TVLTIAHRLNTIMDY-TRVIVLDKGEVAEFGAPSNLLQ 1508

PRK13549

xylose transporter ATP-binding subunit; Provisional

22-228

2.47e-07

xylose transporter ATP-binding subunit; Provisional

Pssm-ID: 184134 [Multi-domain] Cd Length: 506 Bit Score: 52.24 E-value: 2.47e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  22 VDNINLDVPEGEICVLLGPSGCGKTTTLKMInrliepTG-------GTILINGEDT---SALDtvSLRRKIGYVIQ---Q 88
Cdd:PRK13549 278 VDDVSFSLRRGEILGIAGLVGAGRTELVQCL------FGaypgrweGEIFIDGKPVkirNPQQ--AIAQGIAMVPEdrkR 349

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  89 IGLFPNMTIEENIT--VVPRMLGWdkKRCHARAEE---LMSMVALDPKRFLHRYP-KEMSGGQQQRIGVIRALAADPPVL 162
Cdd:PRK13549 350 DGIVPVMGVGKNITlaALDRFTGG--SRIDDAAELktiLESIQRLKVKTASPELAiARLSGGNQQKAVLAKCLLLNPKIL 427

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 727180512 163 LMDEPFGAVDPINRETIQNefldMQRQLKK---TVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADEL 228
Cdd:PRK13549 428 ILDEPTRGIDVGAKYEIYK----LINQLVQqgvAIIVISSELPEVLGLSDRVLVMHEGKLKGDLINHNL 492

COG2905

Signal-transduction protein containing cAMP-binding, CBS, and nucleotidyltransferase domains ...

265-369

3.06e-07

Signal-transduction protein containing cAMP-binding, CBS, and nucleotidyltransferase domains [Signal transduction mechanisms];

Pssm-ID: 442149 [Multi-domain] Cd Length: 124 Bit Score: 48.67 E-value: 3.06e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 265 VTVRRETPLVEAFGLMDDIDARSVTVVDADGKPLGYVKRREARGApgVCADSLHRFR-----------VTARAEENLRVV 333
Cdd:COG2905   10 VTVSPDATVREAARLMTEKGVGSLVVVDDDGRLVGIITDRDLRRR--VLAEGLDPLDtpvsevmtrppITVSPDDSLAEA 87

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 727180512 334 LSKLYEHNTSWMPIVDeDGRYSGEISQDYIADYLSS 369
Cdd:COG2905   88 LELMEEHRIRHLPVVD-DGKLVGIVSITDLLRALSE 122

PRK10938

putative molybdenum transport ATP-binding protein ModF; Provisional

23-204

3.52e-07

putative molybdenum transport ATP-binding protein ModF; Provisional

Pssm-ID: 182852 [Multi-domain] Cd Length: 490 Bit Score: 51.94 E-value: 3.52e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  23 DNINLDVPEGEICVLLGPSGCGKTTTLKMI---------NRLI-----EPTGGTILingedtsaldtvSLRRKIGYVIQQ 88
Cdd:PRK10938 277 HNLSWQVNPGEHWQIVGPNGAGKSTLLSLItgdhpqgysNDLTlfgrrRGSGETIW------------DIKKHIGYVSSS 344

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  89 I----------------GLFPNMTIEENITVVPRMLgwdkkrcharAEELMSMVALDPKrfLHRYP-KEMSGGQQQRIGV 151
Cdd:PRK10938 345 LhldyrvstsvrnvilsGFFDSIGIYQAVSDRQQKL----------AQQWLDILGIDKR--TADAPfHSLSWGQQRLALI 412

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 727180512 152 IRALAADPPVLLMDEPFGAVDPINRETIQnEFLD-MQRQLKKTVMLVSHDIDEA 204
Cdd:PRK10938 413 VRALVKHPTLLILDEPLQGLDPLNRQLVR-RFVDvLISEGETQLLFVSHHAEDA 465

PRK11147

ABC transporter ATPase component; Reviewed

4-200

1.75e-06

ABC transporter ATPase component; Reviewed

Pssm-ID: 236861 [Multi-domain] Cd Length: 635 Bit Score: 49.95 E-value: 1.75e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   4 LENLTKQFMQKNgtpfnAVDNINLDVPEGEICVLLGPSGCGKTTTLK-MINRLiEPTGGTIlingedtsaldTVSLRRKI 82
Cdd:PRK11147 322 MENVNYQIDGKQ-----LVKDFSAQVQRGDKIALIGPNGCGKTTLLKlMLGQL-QADSGRI-----------HCGTKLEV 384

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  83 GYVIQ-QIGLFPNMTIEEN-------ITV--VPR-MLGWDKkrcharaEELMSmvaldPKRflHRYP-KEMSGGQQQRIG 150
Cdd:PRK11147 385 AYFDQhRAELDPEKTVMDNlaegkqeVMVngRPRhVLGYLQ-------DFLFH-----PKR--AMTPvKALSGGERNRLL 450

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 727180512 151 VIRALAADPPVLLMDEPFGAVDPinrETIQ--NEFLDmqrQLKKTVMLVSHD 200
Cdd:PRK11147 451 LARLFLKPSNLLILDEPTNDLDV---ETLEllEELLD---SYQGTVLLVSHD 496

YtoI

COG4109

Predicted transcriptional regulator containing CBS domains [Transcription];

245-361

1.80e-06

Predicted transcriptional regulator containing CBS domains [Transcription];

Pssm-ID: 443285 [Multi-domain] Cd Length: 135 Bit Score: 46.83 E-value: 1.80e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 245 RTLKRLLLVqaGDVAGQQETVTVRRETPLVEAFGLMDDIDARSVTVVDADGKPLGYVKRREARGA-PGVCADSLHRFR-V 322
Cdd:COG4109   10 DTFKEILLV--EDIMTLEDVATLSEDDTVEDALELLEKTGHSRFPVVDENGRLVGIVTSKDILGKdDDTPIEDVMTKNpI 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 727180512 323 TARAEENLRVVLSKLYEHNTSWMPIVDEDGRYSGEIS-QD 361
Cdd:COG4109   88 TVTPDTSLASAAHKMIWEGIELLPVVDDDGRLLGIISrQD 127

GguA

NF040905

sugar ABC transporter ATP-binding protein;

22-227

8.41e-06

sugar ABC transporter ATP-binding protein;

Pssm-ID: 468840 [Multi-domain] Cd Length: 500 Bit Score: 47.48 E-value: 8.41e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  22 VDNINLDVPEGEICVLLGPSGCGKTTtLKM------INRLIeptGGTILINGEDTSaLDTVS--LRRKIGYVIQ---QIG 90
Cdd:NF040905 276 VDDVSLNVRRGEIVGIAGLMGAGRTE-LAMsvfgrsYGRNI---SGTVFKDGKEVD-VSTVSdaIDAGLAYVTEdrkGYG 350

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  91 LFPNMTIEENITVvPRMLGWDKKRCHARAEELMsmVAldpkrflHRYPKEM--------------SGGQQQRIGVIRALA 156
Cdd:NF040905 351 LNLIDDIKRNITL-ANLGKVSRRGVIDENEEIK--VA-------EEYRKKMniktpsvfqkvgnlSGGNQQKVVLSKWLF 420

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727180512 157 ADPPVLLMDEP-----FGAVDPInrETIQNEFLDMqrqlKKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADE 227
Cdd:NF040905 421 TDPDVLILDEPtrgidVGAKYEI--YTIINELAAE----GKGVIVISSELPELLGMCDRIYVMNEGRITGELPREE 490

CBS_pair_arch_MET2_assoc

cd04605

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the ...

265-363

1.85e-05

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the MET2 domain; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the MET2 domain. Met2 is a key enzyme in the biosynthesis of methionine. It encodes a homoserine transacetylase involved in converting homoserine to O-acetyl homoserine. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).

Pssm-ID: 341379 [Multi-domain] Cd Length: 116 Bit Score: 43.38 E-value: 1.85e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 265 VTVRRETPLVEAFGLMDDIDARSVTVVDADGKPLGYVKRREARGAPGVCADSLH----RFRVTARAEENLRVVLSKLYEH 340
Cdd:cd04605   11 ATIREDISIEEAAKIMIDKNVTHLPVVSEDGKLIGIVTSWDISKAVALKKDSLEeimtRNVITARPDEPIELAARKMEKH 90

                         90       100
                 ....*....|....*....|...
gi 727180512 341 NTSWMPIVDEDGRYSGEISQDYI 363
Cdd:cd04605   91 NISALPVVDDDRRVIGIITSDDI 113

PRK10982

galactose/methyl galaxtoside transporter ATP-binding protein; Provisional

7-219

2.01e-05

galactose/methyl galaxtoside transporter ATP-binding protein; Provisional

Pssm-ID: 182880 [Multi-domain] Cd Length: 491 Bit Score: 46.26 E-value: 2.01e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   7 LTKQFMQKNGTPFN--------------AVDNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILINGE---D 69
Cdd:PRK10982 235 LTQRFPDKENKPGEvilevrnltslrqpSIRDVSFDLHKGEILGIAGLVGAKRTDIVETLFGIREKSAGTITLHGKkinN 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  70 TSALDTVslrrKIGYVI-----QQIGLFPNMTIEEN--ITVVPRMLG----WDKKRCHARAEELM-SMVALDPKRflHRY 137
Cdd:PRK10982 315 HNANEAI----NHGFALvteerRSTGIYAYLDIGFNslISNIRNYKNkvglLDNSRMKSDTQWVIdSMRVKTPGH--RTQ 388

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 138 PKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQlKKTVMLVSHDIDEALKLGDRIAVFRQG 217
Cdd:PRK10982 389 IGSLSGGNQQKVIIGRWLLTQPEILMLDEPTRGIDVGAKFEIYQLIAELAKK-DKGIIIISSEMPELLGITDRILVMSNG 467


                 ..
gi 727180512 218 KI 219
Cdd:PRK10982 468 LV 469

PRK14869

putative manganese-dependent inorganic diphosphatase;

262-301

2.55e-05

putative manganese-dependent inorganic diphosphatase;

Pssm-ID: 237843 [Multi-domain] Cd Length: 546 Bit Score: 45.98 E-value: 2.55e-05

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 727180512 262 QETVTVRRETPLVEAFGLMDDIDARSVTVVDADGKPLGYV 301
Cdd:PRK14869  76 DKPVTVSPDTSLKEAWNLMDENNVKTLPVVDEEGKLLGLV 115

3a01205

TIGR00956

Pleiotropic Drug Resistance (PDR) Family protein; [Transport and binding proteins, Other]

23-99

5.40e-05

Pleiotropic Drug Resistance (PDR) Family protein; [Transport and binding proteins, Other]

Pssm-ID: 273362 [Multi-domain] Cd Length: 1394 Bit Score: 45.48 E-value: 5.40e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512    23 DNINLDVPEGEICVLLGPSGCGKTTTLkmiNRLIEP------TGGTILINGEdtsALDTvSLRRKIGYVIQQIGLFPNMT 96
Cdd:TIGR00956  780 NNVDGWVKPGTLTALMGASGAGKTTLL---NVLAERvttgviTGGDRLVNGR---PLDS-SFQRSIGYVQQQDLHLPTST 852


                   ...
gi 727180512    97 IEE 99
Cdd:TIGR00956  853 VRE 855

Rli1

COG1245

Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ...

18-201

6.36e-05

Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis];

Pssm-ID: 440858 [Multi-domain] Cd Length: 592 Bit Score: 44.78 E-value: 6.36e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  18 PFNAVDNINLD----------------------VP-EGEICVLLGPSGCGKTTTLKMINRLIEPTGGtiliNGEDTSALD 74
Cdd:COG1245   62 PFDAISIVNLPeeleedpvhrygengfrlyglpVPkKGKVTGILGPNGIGKSTALKILSGELKPNLG----DYDEEPSWD 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  75 TVsLRRKIGYVIQQiglFPNMTIEENITVV---------PRML---------GWDKKrchARAEELMSMVALDPkrFLHR 136
Cdd:COG1245  138 EV-LKRFRGTELQD---YFKKLANGEIKVAhkpqyvdliPKVFkgtvrelleKVDER---GKLDELAEKLGLEN--ILDR 208

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 727180512 137 YPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINR----ETIQnEFLDMqrqlKKTVMLVSHDI 201
Cdd:COG1245  209 DISELSGGELQRVAIAAALLRDADFYFFDEPSSYLDIYQRlnvaRLIR-ELAEE----GKYVLVVEHDL 272

PRK11147

ABC transporter ATPase component; Reviewed

23-220

7.17e-05

ABC transporter ATPase component; Reviewed

Pssm-ID: 236861 [Multi-domain] Cd Length: 635 Bit Score: 44.94 E-value: 7.17e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  23 DNINLDVPEGEICVLLGPSGCGKTTTLKMINRLIEPTGGTILING--------------EDTSALDTVS--------LRR 80
Cdd:PRK11147  20 DNAELHIEDNERVCLVGRNGAGKSTLMKILNGEVLLDDGRIIYEQdlivarlqqdpprnVEGTVYDFVAegieeqaeYLK 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  81 KIGYVIQQIGLFPNmtiEENITVVPRML-------GWdkkRCHARAEELMSMVALDPKRFLhrypKEMSGGQQQRIGVIR 153
Cdd:PRK11147 100 RYHDISHLVETDPS---EKNLNELAKLQeqldhhnLW---QLENRINEVLAQLGLDPDAAL----SSLSGGWLRKAALGR 169

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 727180512 154 ALAADPPVLLMDEPFGAVDPinrETIQ--NEFLdmqRQLKKTVMLVSHDIDEALKLGDRIAVFRQGKIV 220
Cdd:PRK11147 170 ALVSNPDVLLLDEPTNHLDI---ETIEwlEGFL---KTFQGSIIFISHDRSFIRNMATRIVDLDRGKLV 232

CBS

pfam00571

CBS domain; CBS domains are small intracellular modules that pair together to form a stable ...

322-369

8.34e-05

Pssm-ID: 425756 [Multi-domain] Cd Length: 57 Bit Score: 39.89 E-value: 8.34e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 727180512  322 VTARAEENLRVVLSKLYEHNTSWMPIVDEDGRYSGEISQDYIADYLSS 369
Cdd:pfam00571  10 VTVSPDTTLEEALELMREHGISRLPVVDEDGKLVGIVTLKDLLRALLG 57

PLN03073

ABC transporter F family; Provisional

37-172

1.13e-04

ABC transporter F family; Provisional

Pssm-ID: 215558 [Multi-domain] Cd Length: 718 Bit Score: 44.08 E-value: 1.13e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  37 LLGPSGCGKTTTLK-MINRLIE--PTGGTIL-----INGEDTSALDTVS---------LRRKIGYVIQQIGL-----FPN 94
Cdd:PLN03073 208 LVGRNGTGKTTFLRyMAMHAIDgiPKNCQILhveqeVVGDDTTALQCVLntdiertqlLEEEAQLVAQQRELefeteTGK 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  95 MTIEENITV------------VPRMLGWDKKRCHARAEELMSMVALDPKrFLHRYPKEMSGGQQQRIGVIRALAADPPVL 162
Cdd:PLN03073 288 GKGANKDGVdkdavsqrleeiYKRLELIDAYTAEARAASILAGLSFTPE-MQVKATKTFSGGWRMRIALARALFIEPDLL 366

                        170
                 ....*....|
gi 727180512 163 LMDEPFGAVD 172
Cdd:PLN03073 367 LLDEPTNHLD 376

CBS

pfam00571

CBS domain; CBS domains are small intracellular modules that pair together to form a stable ...

265-309

1.25e-04

Pssm-ID: 425756 [Multi-domain] Cd Length: 57 Bit Score: 39.50 E-value: 1.25e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 727180512  265 VTVRRETPLVEAFGLMDDIDARSVTVVDADGKPLGYVKRREARGA 309
Cdd:pfam00571  10 VTVSPDTTLEEALELMREHGISRLPVVDEDGKLVGIVTLKDLLRA 54

CBS_pair_inorgPPase

cd04597

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with ...

263-359

2.00e-04

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with family II inorganic pyrophosphatase; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a subgroup of family II inorganic pyrophosphatases (PPases) that also contain a DRTGG domain. The homolog from Clostridium has been shown to be inhibited by AMP and activated by a novel effector, diadenosine 5',5-P1,P4-tetraphosphate (AP(4)A), which has been shown to bind to the CBS domain. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here.

Pssm-ID: 341372 [Multi-domain] Cd Length: 106 Bit Score: 40.41 E-value: 2.00e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 263 ETVTVRRETPLVEAFGLMDDIDARSVTVVDADGKPLGYVKRRE-ARGAPGVCADSlhrFRVTARAEENLRVVLSKLYEHN 341
Cdd:cd04597    6 KVEPLSPETSIKDAWNLMDENNLKTLPVTDDNGKLIGLLSISDiARTVDYIMTKD---NLIVFKEDDYLDEVKEIMLNTN 82

                         90
                 ....*....|....*...
gi 727180512 342 TSWMPIVDEDGRYSGEIS 359
Cdd:cd04597   83 FRNYPVVDENNKFLGTIS 100

COG3448

CBS-domain-containing membrane protein [Signal transduction mechanisms];

322-375

2.02e-04

CBS-domain-containing membrane protein [Signal transduction mechanisms];

Pssm-ID: 442671 [Multi-domain] Cd Length: 136 Bit Score: 41.00 E-value: 2.02e-04

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 727180512 322 VTARAEENLRVVLSKLYEHNTSWMPIVDEDGRYSGEISQDYIADYLSSGRTRRV 375
Cdd:COG3448   13 VTVSPDTTLREALELMREHGIRGLPVVDEDGRLVGIVTERDLLRALLPDRLDEL 66

PRK10938

putative molybdenum transport ATP-binding protein ModF; Provisional

111-231

4.11e-04

putative molybdenum transport ATP-binding protein ModF; Provisional

Pssm-ID: 182852 [Multi-domain] Cd Length: 490 Bit Score: 42.31 E-value: 4.11e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 111 DKKRCHARAEELMSMVALDpKRFlhrypKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRETIQNEFLDMQRQl 190
Cdd:PRK10938 112 DPARCEQLAQQFGITALLD-RRF-----KYLSTGETRKTLLCQALMSEPDLLILDEPFDGLDVASRQQLAELLASLHQS- 184

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 727180512 191 KKTVMLVSHDIDEALKLGDRIAVFRQGKIVQNASADELLAR 231
Cdd:PRK10938 185 GITLVLVLNRFDEIPDFVQFAGVLADCTLAETGEREEILQQ 225

CBS

smart00116

Domain in cystathionine beta-synthase and other proteins; Domain present in all 3 forms of ...

263-304

5.23e-04

Domain in cystathionine beta-synthase and other proteins; Domain present in all 3 forms of cellular life. Present in two copies in inosine monophosphate dehydrogenase, of which one is disordered in the crystal structure. A number of disease states are associated with CBS-containing proteins including homocystinuria, Becker's and Thomsen disease.

Pssm-ID: 214522 [Multi-domain] Cd Length: 49 Bit Score: 37.49 E-value: 5.23e-04

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 727180512   263 ETVTVRRETPLVEAFGLMDDIDARSVTVVDADGKPLGYVKRR 304
Cdd:smart00116   1 DVVTVSPDTTLEEALELLRENGIRRLPVVDEEGRLVGIVTRR 42

COG3448

CBS-domain-containing membrane protein [Signal transduction mechanisms];

244-305

2.07e-03

CBS-domain-containing membrane protein [Signal transduction mechanisms];

Pssm-ID: 442671 [Multi-domain] Cd Length: 136 Bit Score: 37.92 E-value: 2.07e-03

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727180512 244 DRTLKRLLLVQAGDVAgQQETVTVRRETPLVEAFGLMDDIDARSVTVVDADGKPLGYVKRRE 305
Cdd:COG3448   64 DELEERLLDLPVEDVM-TRPVVTVTPDTPLEEAAELMLEHGIHRLPVVDDDGRLVGIVTRTD 124

PRK07807

GuaB1 family IMP dehydrogenase-related protein;

265-356

2.24e-03

GuaB1 family IMP dehydrogenase-related protein;

Pssm-ID: 181127 [Multi-domain] Cd Length: 479 Bit Score: 39.89 E-value: 2.24e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 265 VTVRRETPLVEAFGLMDDIDARSVTVVDADGKPLGYVKRREARGAPGV--CADSLHRFRVTARAEENLRVVLSKLYEHNT 342
Cdd:PRK07807 100 VTLSPDDTVGDALALLPKRAHGAVVVVDEEGRPVGVVTEADCAGVDRFtqVRDVMSTDLVTLPAGTDPREAFDLLEAARV 179

                         90
                 ....*....|....
gi 727180512 343 SWMPIVDEDGRYSG 356
Cdd:PRK07807 180 KLAPVVDADGRLVG 193

CBS_pair_plant_CBSX

cd17789

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains from plant CBSX ...

201-303

2.51e-03

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains from plant CBSX proteins; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains of plant single cystathionine beta-synthase (CBS) pair proteins (CBSX). CBSX1 and CBSX2 have been identified as redox regulators of the thioredoxin (Trx) system. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).

Pssm-ID: 341425 [Multi-domain] Cd Length: 141 Bit Score: 37.84 E-value: 2.51e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 201 IDEALKL--GDRIAVF----RQGKIVQNASADELLARPA----NEFVASFVGQDRT------LKRLLLVQAGDVAGQQET 264
Cdd:cd17789   14 VDEALELlvENRITGLpvidEDWRLVGVVSDYDLLALDSisgrSQTDNNFPPADSTwktfneVQKLLSKTNGKVVGDVMT 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 727180512 265 ---VTVRRETPLVEAFGLMDDIDARSVTVVDADGKPLGYVKR 303
Cdd:cd17789   94 pspLVVREKTNLEDAARILLETKFRRLPVVDSDGKLVGIITR 135

CBS_pair_arch1_repeat1

cd17780

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in archaea, ...

262-365

3.34e-03

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in archaea, repeat 1; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).

Pssm-ID: 341416 [Multi-domain] Cd Length: 106 Bit Score: 36.94 E-value: 3.34e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 262 QETVTVRRETPLVEAFGLMDDIDARSVTVVDaDGKPLGYVKRREARGA---PGVCADSLHRFRVTARAEENLRVVLSKLY 338
Cdd:cd17780    2 TEFVEVDADTRLGKVRGLFEDENPKGVVVTD-DGEYEGVVTERQLLQShveDDAKVGALVRAAPKVDRTEDVREVARLLV 80

                         90       100
                 ....*....|....*....|....*..
gi 727180512 339 EHNTSWMPIVdEDGRYSGEISQDYIAD 365
Cdd:cd17780   81 EGGTKVAPVF-EGGSLWGVVTADAILE 106

CBS_pair_ABC_OpuCA_assoc

cd04583

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found associated with ...

265-356

3.69e-03

Pssm-ID: 341360 [Multi-domain] Cd Length: 110 Bit Score: 36.73 E-value: 3.69e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 265 VTVRRETPLVEAFGLMDDIDARSVTVVDADGKPLGYVK----RREARGAPGVcADSLHRFRVTARAEENLRVVLSKLYEH 340
Cdd:cd04583    5 VTITPERTLAQAIEIMREKRVDSLLVVDKDNVLLGIVDiediNRNYRKAKKV-GEIMERDVFTVKEDSLLRDTVDRILKR 83

                         90
                 ....*....|....*.
gi 727180512 341 NTSWMPIVDEDGRYSG 356
Cdd:cd04583   84 GLKYVPVVDEQGRLVG 99

CBS_pair_IMPDH

cd04601

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' ...

265-353

3.78e-03

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key role in the regulation of cell proliferation and differentiation. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).

Pssm-ID: 341376 [Multi-domain] Cd Length: 110 Bit Score: 36.62 E-value: 3.78e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 265 VTVRRETPLVEAFGLMDDIDARSVTVVDADGKPLGYVKRREARGAPgvcaDSLHRFR---------VTARAEENLRVVLS 335
Cdd:cd04601    5 VTLSPDATVADVLELKAEYGISGVPVTEDGGKLVGIVTSRDIRFET----DLSTPVSevmtpderlVTAPEGITLEEAKE 80

                         90
                 ....*....|....*...
gi 727180512 336 KLYEHNTSWMPIVDEDGR 353
Cdd:cd04601   81 ILHKHKIEKLPIVDDNGE 98

PLN03140

ABC transporter G family member; Provisional

32-204

4.86e-03

ABC transporter G family member; Provisional

Pssm-ID: 215599 [Multi-domain] Cd Length: 1470 Bit Score: 39.06 E-value: 4.86e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512   32 GEICVLLGPSGCGKTTTLKMINRliEPTGGTI----LING----EDTSAldtvslrRKIGYVIQQIGLFPNMTIEENITV 103
Cdd:PLN03140  906 GVLTALMGVSGAGKTTLMDVLAG--RKTGGYIegdiRISGfpkkQETFA-------RISGYCEQNDIHSPQVTVRESLIY 976

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512  104 -----VPRMLGWDKKRCHAraEELMSMVALDP-KRFLHRYP--KEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVD--- 172
Cdd:PLN03140  977 saflrLPKEVSKEEKMMFV--DEVMELVELDNlKDAIVGLPgvTGLSTEQRKRLTIAVELVANPSIIFMDEPTSGLDara 1054

                         170       180       190
                  ....*....|....*....|....*....|...
gi 727180512  173 -PINRETIQNEfLDMQRQLKKTVMLVSHDIDEA 204
Cdd:PLN03140 1055 aAIVMRTVRNT-VDTGRTVVCTIHQPSIDIFEA 1086

CBS_pair_ParBc_assoc

cd04610

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a ...

262-359

6.33e-03

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a ParBc (ParB-like nuclease) domain; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a ParBc (ParB-like nuclease) domain downstream. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).

Pssm-ID: 341383 [Multi-domain] Cd Length: 108 Bit Score: 36.14 E-value: 6.33e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180512 262 QETVTVRRETPLVEAFGLMDDIDARSVTVVDaDGKPLGYVKRREARGA---PGVcADSLHRFRVTARAEENLRVVLSKLY 338
Cdd:cd04610    3 RDVITVSPDDTVKDVIKLIKETGHDGFPVVD-DGKVVGYVTAKDLLGKdddEKV-SEIMSRDTVVADPDMDITDAARVIF 80

                         90       100
                 ....*....|....*....|.
gi 727180512 339 EHNTSWMPIVDEDGRYSGEIS 359
Cdd:cd04610   81 RSGISKLPVVDDEGNLVGIIT 101

CBS_pair_CAP-ED_NT_Pol-beta-like_DUF294_assoc

cd17771

CBS domain protein; This cd contains two tandem repeats of the cystathionine beta-synthase ...

260-307

9.17e-03

CBS domain protein; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the bacterial CAP_ED (cAMP receptor protein effector domain) family of transcription factors, the NT_Pol-beta-like domain, and the DUF294 domain. Members of CAP_ED, include CAP which binds cAMP, FNR (fumarate and nitrate reductase) which uses an iron-sulfur cluster to sense oxygen, and CooA a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. The NT_Pol-beta-like domain includes the Nucleotidyltransferase (NT) domains of DNA polymerase beta and other family X DNA polymerases, as well as the NT domains of class I and class II CCA-adding enzymes, RelA- and SpoT-like ppGpp synthetases and hydrolases, 2'5'-oligoadenylate (2-5A)synthetases, Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), poly (A) polymerases, terminal uridylyl transferases, Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins. DUF294 is a putative nucleotidyltransferase with a conserved DxD motif. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide range of different proteins. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).

Pssm-ID: 341407 [Multi-domain] Cd Length: 115 Bit Score: 35.76 E-value: 9.17e-03

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 727180512 260 GQQETVTVRRETPLVEAFGLMDDIDARSVTVVDADGKPLGYVKRREAR 307
Cdd:cd17771    2 IRREPVTCSPDTPLRAALETMHERRVGSMVVVDANRRPVGIFTLRDLL 49

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01