NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|727187696|ref|WP_033649532|]
View 

MULTISPECIES: formate dehydrogenase subunit beta [Enterobacterales]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FDH-beta super family cl36936
formate dehydrogenase, beta subunit, Fe-S containing; This model represents the beta subunit ...
 7-290 1.31e-164

formate dehydrogenase, beta subunit, Fe-S containing; This model represents the beta subunit of the gamma-proteobacterial formate dehydrogenase. This subunit contains four 4Fe-4S clusters and is involved in transmitting electrons from the alpha subunit (TIGR01553) at the periplasmic space to the gamma subunit which spans the cytoplasmic membrane. In addition to the gamma proteobacteria, a sequence from Aquifex aolicus falls within the scope of this model. This appears to be the case for the alpha, gamma and epsilon (accessory protein TIGR01562) chains as well. [Energy metabolism, Anaerobic, Energy metabolism, Electron transport]


The actual alignment was detected with superfamily member TIGR01582:

Pssm-ID: 273705 [Multi-domain]  Cd Length: 283  Bit Score: 458.60  E-value: 1.31e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696    7 DIIRKSATNGftPAPRARDHQEEVAKLIDVTTCIGCKACQVACSEWNDIRDEVG-HNVGVYDNPADLTAKSWTVMRFSEV 85
Cdd:TIGR01582   1 DIKRLSATKE--PDPSVKTYPTELAKLIDVSSCIGCKACQAACQEWNDTTPPILsRKVGGYQNPPDLLPETFTLMRFKEG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696   86 EENGKLEWLIRKDGCMHCADPGCLKACPSEGAIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYKCTLCVD 165
Cdd:TIGR01582  79 EESDGLEWLIRKDGCMHCREPGCLKACPAPGAIIQYQNGIVDFDHSKCIGCGYCIVGCPFNIPRYDKVDNRPYKCTLCID 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  166 RVDVGQEPACVKTCPTGAIHFGTKEAMKQVAADRVSELNTRGYQNAGLYDPAGVGGTHVMYVLHHADKPQLYHGLPDNPS 245
Cdd:TIGR01582 159 RVSVGQEPACVKTCPTNAISFGFKEDMKERAEKRVADLKSRGYPNAGLYDPPGVGGTHVMYVLHHGDKPKDYQDLPEDPR 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 727187696  246 ISPAVTFWKGVWKPLAAIGFAATFAASVFHYVGVGPNRVDDEDEH 290
Cdd:TIGR01582 239 IDASVGLWKGVLKTIGSIAMGGTALGVFLHLILWGPNKVLGGKEE 283
 
Name Accession Description Interval E-value
FDH-beta TIGR01582
formate dehydrogenase, beta subunit, Fe-S containing; This model represents the beta subunit ...
 7-290 1.31e-164

formate dehydrogenase, beta subunit, Fe-S containing; This model represents the beta subunit of the gamma-proteobacterial formate dehydrogenase. This subunit contains four 4Fe-4S clusters and is involved in transmitting electrons from the alpha subunit (TIGR01553) at the periplasmic space to the gamma subunit which spans the cytoplasmic membrane. In addition to the gamma proteobacteria, a sequence from Aquifex aolicus falls within the scope of this model. This appears to be the case for the alpha, gamma and epsilon (accessory protein TIGR01562) chains as well. [Energy metabolism, Anaerobic, Energy metabolism, Electron transport]


Pssm-ID: 273705 [Multi-domain]  Cd Length: 283  Bit Score: 458.60  E-value: 1.31e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696    7 DIIRKSATNGftPAPRARDHQEEVAKLIDVTTCIGCKACQVACSEWNDIRDEVG-HNVGVYDNPADLTAKSWTVMRFSEV 85
Cdd:TIGR01582   1 DIKRLSATKE--PDPSVKTYPTELAKLIDVSSCIGCKACQAACQEWNDTTPPILsRKVGGYQNPPDLLPETFTLMRFKEG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696   86 EENGKLEWLIRKDGCMHCADPGCLKACPSEGAIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYKCTLCVD 165
Cdd:TIGR01582  79 EESDGLEWLIRKDGCMHCREPGCLKACPAPGAIIQYQNGIVDFDHSKCIGCGYCIVGCPFNIPRYDKVDNRPYKCTLCID 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  166 RVDVGQEPACVKTCPTGAIHFGTKEAMKQVAADRVSELNTRGYQNAGLYDPAGVGGTHVMYVLHHADKPQLYHGLPDNPS 245
Cdd:TIGR01582 159 RVSVGQEPACVKTCPTNAISFGFKEDMKERAEKRVADLKSRGYPNAGLYDPPGVGGTHVMYVLHHGDKPKDYQDLPEDPR 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 727187696  246 ISPAVTFWKGVWKPLAAIGFAATFAASVFHYVGVGPNRVDDEDEH 290
Cdd:TIGR01582 239 IDASVGLWKGVLKTIGSIAMGGTALGVFLHLILWGPNKVLGGKEE 283
FDH-N cd10558
The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS ...
 31-238 4.53e-148

The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS subunit of formate dehydrogenase-N (FDH-N), a member of the DMSO reductase family. FDH-N is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. Thus, FDH-N is a major component of nitrate respiration of Escherichia coli. This integral membrane enzyme forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups.


Pssm-ID: 319880 [Multi-domain]  Cd Length: 208  Bit Score: 413.71  E-value: 4.53e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  31 AKLIDVTTCIGCKACQVACSEWNDIRDEVGHNVGVYDNPADLTAKSWTVMRFSEVEENGKLEWLIRKDGCMHCADPGCLK 110
Cdd:cd10558    1 AKLIDVSKCIGCKACQVACKEWNDLRAEVGHNVGTYQNPADLSPETWTLMKFREVEDNGKLEWLIRKDGCMHCADPGCLK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696 111 ACPSEGAIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYKCTLCVDRVDVGQEPACVKTCPTGAIHFGTKE 190
Cdd:cd10558   81 ACPSPGAIVQYANGIVDFQSDKCIGCGYCIKGCPFDIPRISKDDNKMYKCTLCSDRVSVGLEPACVKTCPTGALHFGTKE 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 727187696 191 AMKQVAADRVSELNTRGYQNAGLYDPAGVGGTHVMYVLHHADKPQLYH 238
Cdd:cd10558  161 DMLALAEKRVAALKERGYTNAGLYDPKGVGGTHVMYVLHHADKPEGYP 208
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 25-227 8.00e-70

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 214.43  E-value: 8.00e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  25 DHQEEVAKLIDVTTCIGCKACQVACSEWNDIRDEVghnvgvydnpadltakSWTVMRFSEVEENGKLEWLIRKDGCMHCA 104
Cdd:COG0437    1 LSMKRYGMVIDLTKCIGCRACVVACKEENNLPVGV----------------TWRRVRRYEEGEFPNVEWLFVPVLCNHCD 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696 105 DPGCLKACPSeGAIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYKCTLCVDRVDVGQEPACVKTCPTGAI 184
Cdd:COG0437   65 DPPCVKVCPT-GATYKREDGIVLVDYDKCIGCRYCVAACPYGAPRFNPETGVVEKCTFCADRLDEGLLPACVEACPTGAL 143

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 727187696 185 HFGTKEAMKQVAADRVSELNTRgyqnaGLYDPAGvGGTHVMYV 227
Cdd:COG0437  144 VFGDLDDPESEVSKRLAELPAY-----RLLPELG-TKPSVYYL 180
PRK10882 PRK10882
hydrogenase 2 operon protein HybA;
27-296 4.82e-47

hydrogenase 2 operon protein HybA;


Pssm-ID: 236786 [Multi-domain]  Cd Length: 328  Bit Score: 160.60  E-value: 4.82e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  27 QEEVAKLIDVTTCIGCKACQVACSEWNDIRDEVGHNvGVYDNPADLTAKSWTV--------MRFSEVEENGkleWLIRKD 98
Cdd:PRK10882  35 PGALGMLYDSTLCVGCQACVTKCQEINFPERNPQGE-QTWDNPDKLSPYTNNIikvwksgtGVNKDQEENG---YAYIKK 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  99 GCMHCADPGCLKACPSEGAIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDD--NRVYKCTLC----VDRVDVGQE 172
Cdd:PRK10882 111 QCMHCVDPNCVSVCPVSALTKDPKTGIVHYDKDVCTGCRYCMVACPFNVPKYDYNNpfGAIHKCELCnqkgVERLDKGGL 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696 173 PACVKTCPTGAIHFGTKEAMKQVAADRVSE-------------------LNTRGYQNAGLYDPAGVGGTHVMYvLHHADK 233
Cdd:PRK10882 191 PGCVEVCPTGAVIFGTREELLAEAKRRLALkpgseyhyprqtlksgdtyLHTVPKYYPHVYGEKEGGGTQVLV-LSGVPF 269

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696 234 PQLyhGLPDNPSISPAV-------TFWKGVWKPLAAIGFAATFAASvfhyvgvgpNRVDDEDEHDESHDE 296
Cdd:PRK10882 270 ENL--GLPKLDDLSTGArsehiqhTLYKGMILPLAVLAGLTVLVRR---------NTKNDHHDGGDDHES 328
Fer4_11 pfam13247
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 91-187 2.79e-29

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 404184 [Multi-domain]  Cd Length: 99  Bit Score: 107.33  E-value: 2.79e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696   91 LEWLIRKDGCMHCADPGCLKACPSeGAIIQ-YANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYKCTLCVDRVDV 169
Cdd:pfam13247   1 VDWLFFPEQCRHCLNPPCKASCPV-GAIYKdEETGAVLLDEKTCRGWRECVSACPYNIPRYNDETGKAEKCDMCYDRVEA 79

                          90
                  ....*....|....*...
gi 727187696  170 GQEPACVKTCPTGAIHFG 187
Cdd:pfam13247  80 GLLPACVQTCPTGAMNFG 97
FDH3_beta NF038355
formate dehydrogenase FDH3 subunit beta; Members of this family are the beta subunit of the ...
 33-208 3.47e-20

formate dehydrogenase FDH3 subunit beta; Members of this family are the beta subunit of the FDH3 type of formate dehydrogenase as found in Methylorubrum (Methylobacterium) extorquens.


Pssm-ID: 439648 [Multi-domain]  Cd Length: 180  Bit Score: 85.89  E-value: 3.47e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  33 LIDVTTCIGCKACQVACSEWNDIrdEVGHN----VGVYDNPADltAKSWTVmrfseveengklewlirkdGCMHCADPGC 108
Cdd:NF038355   6 LCDTERCIECNGCVVACKNAHEL--PWGINrrrvVTLNDGVPG--EKSISV-------------------ACMHCTDAPC 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696 109 LKACPSEgAIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDN-----RVYKCTLC-----------------VDR 166
Cdd:NF038355  63 AAVCPVD-CFYIRADGIVLHDKDKCIGCGYCLYACPFGAPQFPKDGAfgargKMDKCTFCaggpeetnseaerekygQNR 141

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 727187696 167 VDVGQEPACVKTCPTGAIHFGTKEAMKQVAADRVSelnTRGY 208
Cdd:NF038355 142 IAEGKLPLCAEMCSTKALLAGDAEVVADIYRERVV---ARGA 180
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 130-189 5.17e-06

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 46.78  E-value: 5.17e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727187696 130 SEHCIGCGYCIAGCPFDVPRMnkDDNRVY---KCTLCVdrvdvgqepACVKTCPTGAIHFGTK 189
Cdd:NF038196 184 TDKCIGCGICAKVCPVNNIEM--EDGKPVwghNCTHCL---------ACIHRCPKEAIEYGKK 235
 
Name Accession Description Interval E-value
FDH-beta TIGR01582
formate dehydrogenase, beta subunit, Fe-S containing; This model represents the beta subunit ...
 7-290 1.31e-164

formate dehydrogenase, beta subunit, Fe-S containing; This model represents the beta subunit of the gamma-proteobacterial formate dehydrogenase. This subunit contains four 4Fe-4S clusters and is involved in transmitting electrons from the alpha subunit (TIGR01553) at the periplasmic space to the gamma subunit which spans the cytoplasmic membrane. In addition to the gamma proteobacteria, a sequence from Aquifex aolicus falls within the scope of this model. This appears to be the case for the alpha, gamma and epsilon (accessory protein TIGR01562) chains as well. [Energy metabolism, Anaerobic, Energy metabolism, Electron transport]


Pssm-ID: 273705 [Multi-domain]  Cd Length: 283  Bit Score: 458.60  E-value: 1.31e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696    7 DIIRKSATNGftPAPRARDHQEEVAKLIDVTTCIGCKACQVACSEWNDIRDEVG-HNVGVYDNPADLTAKSWTVMRFSEV 85
Cdd:TIGR01582   1 DIKRLSATKE--PDPSVKTYPTELAKLIDVSSCIGCKACQAACQEWNDTTPPILsRKVGGYQNPPDLLPETFTLMRFKEG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696   86 EENGKLEWLIRKDGCMHCADPGCLKACPSEGAIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYKCTLCVD 165
Cdd:TIGR01582  79 EESDGLEWLIRKDGCMHCREPGCLKACPAPGAIIQYQNGIVDFDHSKCIGCGYCIVGCPFNIPRYDKVDNRPYKCTLCID 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  166 RVDVGQEPACVKTCPTGAIHFGTKEAMKQVAADRVSELNTRGYQNAGLYDPAGVGGTHVMYVLHHADKPQLYHGLPDNPS 245
Cdd:TIGR01582 159 RVSVGQEPACVKTCPTNAISFGFKEDMKERAEKRVADLKSRGYPNAGLYDPPGVGGTHVMYVLHHGDKPKDYQDLPEDPR 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 727187696  246 ISPAVTFWKGVWKPLAAIGFAATFAASVFHYVGVGPNRVDDEDEH 290
Cdd:TIGR01582 239 IDASVGLWKGVLKTIGSIAMGGTALGVFLHLILWGPNKVLGGKEE 283
FDH-N cd10558
The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS ...
 31-238 4.53e-148

The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS subunit of formate dehydrogenase-N (FDH-N), a member of the DMSO reductase family. FDH-N is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. Thus, FDH-N is a major component of nitrate respiration of Escherichia coli. This integral membrane enzyme forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups.


Pssm-ID: 319880 [Multi-domain]  Cd Length: 208  Bit Score: 413.71  E-value: 4.53e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  31 AKLIDVTTCIGCKACQVACSEWNDIRDEVGHNVGVYDNPADLTAKSWTVMRFSEVEENGKLEWLIRKDGCMHCADPGCLK 110
Cdd:cd10558    1 AKLIDVSKCIGCKACQVACKEWNDLRAEVGHNVGTYQNPADLSPETWTLMKFREVEDNGKLEWLIRKDGCMHCADPGCLK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696 111 ACPSEGAIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYKCTLCVDRVDVGQEPACVKTCPTGAIHFGTKE 190
Cdd:cd10558   81 ACPSPGAIVQYANGIVDFQSDKCIGCGYCIKGCPFDIPRISKDDNKMYKCTLCSDRVSVGLEPACVKTCPTGALHFGTKE 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 727187696 191 AMKQVAADRVSELNTRGYQNAGLYDPAGVGGTHVMYVLHHADKPQLYH 238
Cdd:cd10558  161 DMLALAEKRVAALKERGYTNAGLYDPKGVGGTHVMYVLHHADKPEGYP 208
FDH_beta_like cd16366
beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family ...
 32-187 4.55e-87

beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family contains beta FeS subunits of several dehydrogenases in the DMSO reductase superfamily, including formate dehydrogenase N (FDH-N), tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N is a major component of nitrate respiration of Escherichia coli; it catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate to a cytochrome. W-FDH contains a tungsten instead of molybdenum at the catalytic center and seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate.


Pssm-ID: 319888 [Multi-domain]  Cd Length: 156  Bit Score: 257.33  E-value: 4.55e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  32 KLIDVTTCIGCKACQVACSEWNDIRDEVGHNVGVYDNPADLTAKSWTVMRFSEVEEN-GKLEWLIRKDGCMHCADPGCLK 110
Cdd:cd16366    1 FLVDTSRCTGCRACQVACKQWNGLPAEKTEFTGSYQNPPDLTAHTWTLVRFYEVEKPgGDLSWLFRKDQCMHCTDAGCLA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 727187696 111 ACPSeGAIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYKCTLCVDRVDVGQEPACVKTCPTGAIHFG 187
Cdd:cd16366   81 ACPT-GAIIRTETGTVVVDPETCIGCGYCVNACPFDIPRFDEETGRVAKCTLCYDRISNGLQPACVKTCPTGALTFG 156
FDH-O_like cd10560
beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes ...
 33-244 8.87e-81

beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes beta subunit of formate dehydrogenase family O (FDH-O), which is highly homologous to formate dehydrogenase N (FDH-N), a member of the DMSO reductase family. In E. coli three formate dehydrogenases are synthesized that are capable of oxidizing formate; Fdh-H, couples formate disproportionation to hydrogen and CO2, and is part of the cytoplasmically oriented formate hydrogenlyase complex, while FDH-N and FDH-O indicate their respective induction after growth with nitrate and oxygen. Little is known about FDH-O, although it shows formate oxidase activity during aerobic growth and is also synthesized during nitrate respiration, similar to FDH-N.


Pssm-ID: 319882 [Multi-domain]  Cd Length: 225  Bit Score: 243.83  E-value: 8.87e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  33 LIDVTTCIGCKACQVACSEWNDIRDEVGHNVG-VYDNPADLTAKSWTVMRFSEV-------EENGKLEWLIRKDGCMHCA 104
Cdd:cd10560    3 FTDTSICIGCKACEVACKQWNQLPADGYDFSGmSYDNTGDLSASTWRHVKFIERptedgpaNEGGDLQWLFMSDVCKHCT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696 105 DPGCLKACPSeGAIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYKCTLCVDRVDVGQEPACVKTCPTGAI 184
Cdd:cd10560   83 DAGCLEACPT-GAIFRTEFGTVYIQPDICNGCGYCVAACPFGVIDRNEETGRAHKCTLCYDRLKDGLEPACAKACPTGSI 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727187696 185 HFGTKEAMKQVAADRVSELNTRGYQNAGLY--DP-AGVGGTHVMYVLhhADKPQLYhGLPDNP 244
Cdd:cd10560  162 QFGPLEELRERARARVEQLHEQGVVEAYLYgaDPtEGYGGLNAFFLL--LDKPEVY-GLPADP 221
FDH_b_like cd10562
uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes ...
 32-192 3.12e-75

uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319884 [Multi-domain]  Cd Length: 161  Bit Score: 227.19  E-value: 3.12e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  32 KLIDVTTCIGCKACQVACSEWNDIRDEVGHNVGVYDNPADLTAKSWTVMRFSEVEE-NGKLEWLIRKDGCMHCADPGCLK 110
Cdd:cd10562    1 MLVDTSKCTACRGCQVACKQWNQLPAEKTPFTGSYQNPPDLTPNTWTLIRFYEHEEdNGGIRWLFRKRQCMHCTDAACVK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696 111 ACPsEGAIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYKCTLCVDRVDVGQEPACVKTCPTGAIHFGTKE 190
Cdd:cd10562   81 VCP-TGALYKTENGAVVVDEDKCIGCGYCVAACPFDVPRYDETTNKITKCTLCFDRIENGMQPACVKTCPTGALTFGDRD 159


                 ..
gi 727187696 191 AM 192
Cdd:cd10562  160 EL 161
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 25-227 8.00e-70

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 214.43  E-value: 8.00e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  25 DHQEEVAKLIDVTTCIGCKACQVACSEWNDIRDEVghnvgvydnpadltakSWTVMRFSEVEENGKLEWLIRKDGCMHCA 104
Cdd:COG0437    1 LSMKRYGMVIDLTKCIGCRACVVACKEENNLPVGV----------------TWRRVRRYEEGEFPNVEWLFVPVLCNHCD 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696 105 DPGCLKACPSeGAIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYKCTLCVDRVDVGQEPACVKTCPTGAI 184
Cdd:COG0437   65 DPPCVKVCPT-GATYKREDGIVLVDYDKCIGCRYCVAACPYGAPRFNPETGVVEKCTFCADRLDEGLLPACVEACPTGAL 143

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 727187696 185 HFGTKEAMKQVAADRVSELNTRgyqnaGLYDPAGvGGTHVMYV 227
Cdd:COG0437  144 VFGDLDDPESEVSKRLAELPAY-----RLLPELG-TKPSVYYL 180
HybA_like cd10561
the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 ...
 31-226 8.55e-67

the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 (Hyd-2), an enzyme that catalyzes the reversible oxidation of H2 to protons and electrons. Hyd-2 is membrane-associated and forms an unusual heterotetrameric [NiFe]-hydrogenase in that it lacks the typical cytochrome b membrane anchor subunit that transfers electrons to the quinone pool. The electron transfer subunit of Hyd-2 (HybA) which is predicted to contain four iron-sulfur clusters, is essential for electron transfer from Hyd-2 to menaquinone/demethylmenaquinone (MQ/DMQ) to couple hydrogen oxidation to fumarate reduction.


Pssm-ID: 319883 [Multi-domain]  Cd Length: 196  Bit Score: 207.06  E-value: 8.55e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  31 AKLIDVTTCIGCKACQVACSEWNDIRDEVGHNVGVYDNPADLTAKSWTVMRFSEVeENGKLEWLIRKDGCMHCADPGCLK 110
Cdd:cd10561    1 GVLYDTTRCIGCRACEVACKEWNGLPAEDTAFGPGWDNPRDLSAKTYTVIKRYEV-ETGGKGFVFVKRQCMHCLDPACVS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696 111 ACPSeGAIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRM--NKDDNRVYKCTLCVDRVDVGQEPACVKTCPTGAIHFGT 188
Cdd:cd10561   80 ACPV-GALRKTPEGPVTYDEDKCIGCRYCMVACPFNIPKYewDSANPKIRKCTMCYDRLKEGKQPACVEACPTGALLFGK 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 727187696 189 KEAMKQVAADRVsELNTRGYQNA--GLYDpagVGGTHVMY 226
Cdd:cd10561  159 REELLAEAKRRI-AANPGRYVDHvyGEKE---AGGTSVLY 194
W-FDH cd10559
tungsten-containing formate dehydrogenase, small subunit; This subfamily contains beta subunit ...
 33-230 1.95e-61

tungsten-containing formate dehydrogenase, small subunit; This subfamily contains beta subunit of Tungsten-containing formate dehydrogenase (W-FDH), a member of the DMSO reductase family. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319881 [Multi-domain]  Cd Length: 200  Bit Score: 193.42  E-value: 1.95e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  33 LIDVTTCIGCKACQVACSEWNDIRDEVGHNVGVYDNPADLTAKSWTVMRFSEVE-ENGKLEWLIRKDGCMHCADPGCLKA 111
Cdd:cd10559    3 LIDTTRCTACRGCQVACKQWNQLPAEQTKNTGSHQNPPDLSANTYKLVRFNEVRnENGKPDWLFFPDQCRHCVTPPCKDA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696 112 CPS-EGAIIQ-YANGIVDFQSEHCIGC-GYCIAGCPFDVPRMNKDDNRVYKCTLCVDRVDVGQEPACVKTCPTGAIHFGT 188
Cdd:cd10559   83 ADMvPGAVIQdEATGAVVFTEKTAELDfDDVLSACPYNIPRKNEATGRIVKCDMCIDRVSNGLQPACVKACPTGAMNFGD 162

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 727187696 189 KEAMKQVAADRVSELNTRgYQNAGLYDPAGVggtHVMYVLHH 230
Cdd:cd10559  163 RDEMLAMASKRLEELKKR-YPKANLYDPDDV---RVIWLLAE 200
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 33-187 3.01e-50

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 162.56  E-value: 3.01e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  33 LIDVTTCIGCKACQVACSEWNDIRdevghnvgvydnpadlTAKSWTVMRfseVEENGKLEWLIRKDGCMHCADPGCLKAC 112
Cdd:cd04410    2 VVDLDRCIGCGTCEVACKQEHGLR----------------PGPDWSRIK---VIEGGGLERAFLPVSCMHCEDPPCVKAC 62

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727187696 113 PSeGAIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYKCTLCVDRVDVGQEPACVKTCPTGAIHFG 187
Cdd:cd04410   63 PT-GAIYKDEDGIVLIDEDKCIGCGSCVEACPYGAIVFDPEPGKAVKCDLCGDRLDEGLEPACVKACPTGALTFG 136
DMSOR_beta_like cd16371
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 33-187 5.36e-50

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319893 [Multi-domain]  Cd Length: 140  Bit Score: 161.96  E-value: 5.36e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  33 LIDVTTCIGCKACQVACSEWNDIRDEVghnvgvydnpadltakswtvmRFSEVEENGKLEWLIRKD-----GCMHCADPG 107
Cdd:cd16371    3 YFDQERCIGCKACEIACKDKNDLPPGV---------------------NWRRVYEYEGGEFPEVFAyflsmSCNHCENPA 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696 108 CLKACPsEGAIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYKCTLCVDRVDVGQEPACVKTCPTGAIHFG 187
Cdd:cd16371   62 CVKVCP-TGAITKREDGIVVVDQDKCIGCGYCVWACPYGAPQYNPETGKMDKCDMCVDRLDEGEKPACVAACPTRALDFG 140
PRK10882 PRK10882
hydrogenase 2 operon protein HybA;
27-296 4.82e-47

hydrogenase 2 operon protein HybA;


Pssm-ID: 236786 [Multi-domain]  Cd Length: 328  Bit Score: 160.60  E-value: 4.82e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  27 QEEVAKLIDVTTCIGCKACQVACSEWNDIRDEVGHNvGVYDNPADLTAKSWTV--------MRFSEVEENGkleWLIRKD 98
Cdd:PRK10882  35 PGALGMLYDSTLCVGCQACVTKCQEINFPERNPQGE-QTWDNPDKLSPYTNNIikvwksgtGVNKDQEENG---YAYIKK 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  99 GCMHCADPGCLKACPSEGAIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDD--NRVYKCTLC----VDRVDVGQE 172
Cdd:PRK10882 111 QCMHCVDPNCVSVCPVSALTKDPKTGIVHYDKDVCTGCRYCMVACPFNVPKYDYNNpfGAIHKCELCnqkgVERLDKGGL 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696 173 PACVKTCPTGAIHFGTKEAMKQVAADRVSE-------------------LNTRGYQNAGLYDPAGVGGTHVMYvLHHADK 233
Cdd:PRK10882 191 PGCVEVCPTGAVIFGTREELLAEAKRRLALkpgseyhyprqtlksgdtyLHTVPKYYPHVYGEKEGGGTQVLV-LSGVPF 269

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696 234 PQLyhGLPDNPSISPAV-------TFWKGVWKPLAAIGFAATFAASvfhyvgvgpNRVDDEDEHDESHDE 296
Cdd:PRK10882 270 ENL--GLPKLDDLSTGArsehiqhTLYKGMILPLAVLAGLTVLVRR---------NTKNDHHDGGDDHES 328
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
 33-187 7.17e-45

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 150.38  E-value: 7.17e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  33 LIDVTTCIGCKACQVACSEWNDIRDEVGHNvgvydnpadltaksWTVMRFSEVEENGKLEWLIRkdGCMHCADPGCLKAC 112
Cdd:cd10551    2 VIDLRKCIGCGACVVACKAENNVPPGVFRN--------------RVLEYEVGEYPNVKRTFLPV--LCNHCENPPCVKVC 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696 113 PSeGAIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVY------------KCTLCVDRVDVGQEPACVKTCP 180
Cdd:cd10551   66 PT-GATYKREDGIVLVDYDKCIGCRYCMAACPYGARYFNPEEPHEFgevpvrpkgvveKCTFCYHRLDEGLLPACVEACP 144


                 ....*..
gi 727187696 181 TGAIHFG 187
Cdd:cd10551  145 TGARIFG 151
DMSOR_beta_like cd16369
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 34-194 1.67e-33

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319891 [Multi-domain]  Cd Length: 172  Bit Score: 120.57  E-value: 1.67e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  34 IDVTTCIGCKACQVACSEWNDIRDEVGHNVGvYDNPADLTAKSWTVmrfseveengklewlirkdgCMHCADPGCLKACP 113
Cdd:cd16369    6 IDPSRCIGCRACVAACRECGTHRGKSMIHVD-YIDRGESTQTAPTV--------------------CMHCEDPTCAEVCP 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696 114 SEgAIIQYANGIV-DFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYKCTLCVDRVDVGQEPACVKTCPTGAIHFGTKEAM 192
Cdd:cd16369   65 AD-AIKVTEDGVVqSALKPRCIGCSNCVNACPFGVPKYDEERNLMMKCDMCYDRTSVGKAPMCASVCPSGALFYGTREEI 143


                 ..
gi 727187696 193 KQ 194
Cdd:cd16369  144 QA 145
PhsB_like cd10553
uncharacterized beta subfamily of DMSO Reductase similar to Desulfonauticus sp PhsB; This ...
 35-188 4.74e-33

uncharacterized beta subfamily of DMSO Reductase similar to Desulfonauticus sp PhsB; This family includes beta FeS subunits of anaerobic DMSO reductase (DMSOR) superfamily that have yet to be characterized. DMSOR consists of a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and the tungsten-containing formate dehydrogenase (FDH-T). Examples of heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319875 [Multi-domain]  Cd Length: 146  Bit Score: 118.62  E-value: 4.74e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  35 DVTTCIGCKACQVACSEWNdirdevghNVGVYDNPADLTAkswtvmrFSEVEENGKLEWLIRKDGCMHCADPGCLKACPS 114
Cdd:cd10553    8 DSKRCIGCLACEVHCKVKN--------NLPVGPRLCRIFA-------VGPKMVGGKPRLKFVYMSCFHCENPWCVKACPT 72

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727187696 115 eGAIIQY-ANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYKCTLCVDRVDVGQEPACVKTCPTGAIHFGT 188
Cdd:cd10553   73 -GAMQKReKDGIVYVDQELCIGCKACIEACPWGIPQWNPATGKVVKCDYCMDRIDQGLKPACVTGCTTHALSFVR 146
DMSOR_beta_like cd16374
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 33-194 5.15e-33

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319896 [Multi-domain]  Cd Length: 139  Bit Score: 118.15  E-value: 5.15e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  33 LIDVTTCIGCKACQVACSEWNDIRDEVghNVGVYDnpaDLTAKSWTvmrfseveengklewlirkdgCMHCADPGCLKAC 112
Cdd:cd16374    2 YVDPERCIGCRACEIACAREHSGKPRI--SVEVVE---DLASVPVR---------------------CRHCEDAPCMEVC 55

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696 113 PSeGAIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYKCTLCVDRVDVGQEPACVKTCPTGAIHFGT-KEA 191
Cdd:cd16374   56 PT-GAIYRDEDGAVLVDPDKCIGCGMCAMACPFGVPRFDPSLKVAVKCDLCIDRRREGKLPACVEACPTGALKFGDiEEL 134


                 ...
gi 727187696 192 MKQ 194
Cdd:cd16374  135 LKE 137
Fer4_11 pfam13247
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 91-187 2.79e-29

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 404184 [Multi-domain]  Cd Length: 99  Bit Score: 107.33  E-value: 2.79e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696   91 LEWLIRKDGCMHCADPGCLKACPSeGAIIQ-YANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYKCTLCVDRVDV 169
Cdd:pfam13247   1 VDWLFFPEQCRHCLNPPCKASCPV-GAIYKdEETGAVLLDEKTCRGWRECVSACPYNIPRYNDETGKAEKCDMCYDRVEA 79

                          90
                  ....*....|....*...
gi 727187696  170 GQEPACVKTCPTGAIHFG 187
Cdd:pfam13247  80 GLLPACVQTCPTGAMNFG 97
CooF_like cd10563
CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the ...
 33-187 1.33e-28

CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the iron-sulfur subunit of carbon monoxide dehydrogenase (CODH), found in anaerobic bacteria and archaea. Carbon monoxide dehydrogenase is a key enzyme for carbon monoxide (CO) metabolism, where CooF is the proposed mediator of electron transfer between CODH and the CO-induced hydrogenase, catalyzing the reaction that uses CO as a single carbon and energy source, and producing only H2 and CO2. The ion-sulfur subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons in the protein complex during reaction.


Pssm-ID: 319885 [Multi-domain]  Cd Length: 140  Bit Score: 106.96  E-value: 1.33e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  33 LIDVTTCIGCKACQVACSewndirdeVGHNVgvYDNPADLTAKSWTVMRFSEVEENGKLEWLIRkdgCMHCADPGCLKAC 112
Cdd:cd10563    3 FIDEEKCLGCKLCEVACA--------VAHSK--SKDLIKAKLEKERPRPRIRVEESGGRSFPLQ---CRHCDEPPCVKAC 69

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727187696 113 PSeGAIIQY-ANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYKCTLCVDRvdvgQEPACVKTCPTGAIHFG 187
Cdd:cd10563   70 MS-GAMHKDpETGIVIHDEEKCVGCWMCVMVCPYGAIRPDKERKVALKCDLCPDR----ETPACVEACPTGALVLE 140
DMSOR_beta_like cd16368
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 30-197 1.79e-28

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319890 [Multi-domain]  Cd Length: 200  Bit Score: 108.28  E-value: 1.79e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  30 VAKLIDVTTCIGCK-----ACQVACSEWNDIR--DEVGHNVGVY-------------DNPADLTAKSWTVMRFSEVEENG 89
Cdd:cd16368    1 LATLIDLTKCDGCPgesipACVRACREKNQARfpEPVSKPIQPYwprkriedwsdkrDVTDRLTPYNWLYVQKLTVDTAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  90 KLEWLIRKDGCMHCADPGCLKACPSeGAIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKD-------------DNR 156
Cdd:cd16368   81 GEKEVFIPRRCMHCDNPPCAKLCPF-GAARKTPEGAVYIDDDLCFGGAKCRDVCPWHIPQRQAGvgiylhlapeyagGGV 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 727187696 157 VYKCTLCVDRVDVGQEPACVKTCPTGAIHFGTKEAMKQVAA 197
Cdd:cd16368  160 MYKCDLCKDLLAQGKPPACIEACPKGAQYFGPRKEMVALAR 200
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 33-186 5.13e-28

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 104.97  E-value: 5.13e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  33 LIDVTTCIGCKACQVACSEwndirdevgHNVGVYdNPAdltaKS-WTVMRFsevEENGklewLIRKDGCMHCADPGCLKA 111
Cdd:cd10550    2 VVDPEKCTGCRTCELACSL---------KHEGVF-NPS----LSrIRVVRF---EPEG----LDVPVVCRQCEDAPCVEA 60

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727187696 112 CPsEGAIIQ-YANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYKCTLCvdrvdvGQEPACVKTCPTGAIHF 186
Cdd:cd10550   61 CP-VGAISRdEETGAVVVDEDKCIGCGMCVEACPFGAIRVDPETGKAIKCDLC------GGDPACVKVCPTGALEF 129
PRK14993 PRK14993
tetrathionate reductase subunit TtrB;
13-183 6.04e-27

tetrathionate reductase subunit TtrB;


Pssm-ID: 184955 [Multi-domain]  Cd Length: 244  Bit Score: 105.73  E-value: 6.04e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  13 ATNGFTPAPRARDHQEEVAKLIDVTTCIGCKACQVACSEWNDI-RDEVGHNVGVYDnpadltakswTVMRFSEVEENGKL 91
Cdd:PRK14993  27 AKFPFSPERHEGSPRHRYAMLIDLRRCIGCQSCTVSCTIENQTpQGAFRTTVNQYQ----------VQREGSQEVTNVLL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  92 EWLirkdgCMHCADPGCLKACPSEgAIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYKCTLCVDRVDVGQ 171
Cdd:PRK14993  97 PRL-----CNHCDNPPCVPVCPVQ-ATFQREDGIVVVDNKRCVGCAYCVQACPYDARFINHETQTADKCTFCVHRLEAGL 170

                        170
                 ....*....|..
gi 727187696 172 EPACVKTCPTGA 183
Cdd:PRK14993 171 LPACVESCVGGA 182
TH_beta_N cd10552
N-terminal FeS domain of pyrogallol-phloroglucinol transhydroxylase (TH), beta subunit; This ...
 33-203 2.16e-24

N-terminal FeS domain of pyrogallol-phloroglucinol transhydroxylase (TH), beta subunit; This family includes the beta subunit of pyrogallol-phloroglucinol transhydroxylase (TH), a cytoplasmic molybdenum (Mo) enzyme from anaerobic microorganisms like Pelobacter acidigallici and Desulfitobacterium hafniense which catalyzes the conversion of pyrogallol to phloroglucinol, an important building block of plant polymers. TH belongs to the DMSO reductase (DMSOR) family; it is a heterodimer consisting of a large alpha catalytic subunit and a small beta FeS subunit. The beta subunit has two domains with the N-terminal domain containing three [4Fe-4S] centers and a seven-stranded, mainly antiparallel beta-barrel domain. In the anaerobic bacterium Pelobacter acidigallici, gallic acid, pyrogallol, phloroglucinol, or phloroglucinol carboxylic acid are fermented to three molecules of acetate (plus CO2), and TH is the key enzyme in the fermentation pathway, which converts pyrogallol to phloroglucinol in the absence of O2.


Pssm-ID: 319874 [Multi-domain]  Cd Length: 186  Bit Score: 97.01  E-value: 2.16e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  33 LIDVTTCIGCKACQVACsewndiRDE-VGHNVGVYDNPADLTAKSWtvMRFSEvEENG---KLEWLIRKDGCMHCADPGC 108
Cdd:cd10552    2 VIDVAKCNGCYNCFLAC------KDEhVGNDWPGYAAPQPRHGHFW--MRILR-RERGqypKVDVAYLPVPCNHCDNAPC 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696 109 LKACPSeGAIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYKCTLCVDRVDVG-QEPACVKTCPTGAIHFG 187
Cdd:cd10552   73 IKAAKD-GAVYKRDDGIVIIDPEKAKGQKQLVDACPYGAIYWNEELQVPQKCTFCAHLLDDGwKEPRCVQACPTGALRFG 151

                        170
                 ....*....|....*...
gi 727187696 188 --TKEAMKQVAADRVSEL 203
Cdd:cd10552  152 klEDEEMAAKAAEEGLEV 169
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
33-186 4.14e-23

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 92.41  E-value: 4.14e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  33 LIDVTTCIGCKACQVACSewndirdeVGHNVGVYDNPADltakswtvmRFSeVEENGKLEWLIRkdgCMHCADPGCLKAC 112
Cdd:COG1142    6 IADPEKCIGCRTCEAACA--------VAHEGEEGEPFLP---------RIR-VVRKAGVSAPVQ---CRHCEDAPCAEVC 64

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727187696 113 PsEGAIIQyANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNR--VYKCTLCVDRVDVgqePACVKTCPTGAIHF 186
Cdd:COG1142   65 P-VGAITR-DDGAVVVDEEKCIGCGLCVLACPFGAITMVGEKSRavAVKCDLCGGREGG---PACVEACPTGALRL 135
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 39-186 6.62e-23

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 91.94  E-value: 6.62e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  39 CIGCKACQVACSEWNdirdEVGHNVGVYDNPADLTAKSWtvmrfseveengklewLIRKDG------CMHCADPGCLKAC 112
Cdd:cd10554    9 CIGCRTCEVACAAAH----SGKGIFEAGTDGLPFLPRLR----------------VVKTGEvtapvqCRQCEDAPCANVC 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696 113 PSeGAIIQyANGIVDFQSEHCIGCGYCIAGCPFDVPRM---------NKDDNR--VYKCTLCVDRVDvgqEPACVKTCPT 181
Cdd:cd10554   69 PV-GAISQ-EDGVVQVDEERCIGCKLCVLACPFGAIEMapttvpgvdWERGPRavAVKCDLCAGREG---GPACVEACPT 143


                 ....*
gi 727187696 182 GAIHF 186
Cdd:cd10554  144 KALTL 148
Form-deh_trans pfam09163
Formate dehydrogenase N, transmembrane; Members of this family are predominantly found in the ...
 246-288 2.30e-20

Formate dehydrogenase N, transmembrane; Members of this family are predominantly found in the beta subunit of formate dehydrogenase, and consist of a single transmembrane helix. They act as a transmembrane anchor, and allow for conduction of electrons within the protein.


Pssm-ID: 430440  Cd Length: 43  Bit Score: 82.28  E-value: 2.30e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 727187696  246 ISPAVTFWKGVWKPLAAIGFAATFAASVFHYVGVGPNRVDDED 288
Cdd:pfam09163   1 ISPSVELWKGVLKPLGAAGMGAAALAGFFHYITVGPNKVEEEE 43
FDH3_beta NF038355
formate dehydrogenase FDH3 subunit beta; Members of this family are the beta subunit of the ...
 33-208 3.47e-20

formate dehydrogenase FDH3 subunit beta; Members of this family are the beta subunit of the FDH3 type of formate dehydrogenase as found in Methylorubrum (Methylobacterium) extorquens.


Pssm-ID: 439648 [Multi-domain]  Cd Length: 180  Bit Score: 85.89  E-value: 3.47e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  33 LIDVTTCIGCKACQVACSEWNDIrdEVGHN----VGVYDNPADltAKSWTVmrfseveengklewlirkdGCMHCADPGC 108
Cdd:NF038355   6 LCDTERCIECNGCVVACKNAHEL--PWGINrrrvVTLNDGVPG--EKSISV-------------------ACMHCTDAPC 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696 109 LKACPSEgAIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDN-----RVYKCTLC-----------------VDR 166
Cdd:NF038355  63 AAVCPVD-CFYIRADGIVLHDKDKCIGCGYCLYACPFGAPQFPKDGAfgargKMDKCTFCaggpeetnseaerekygQNR 141

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 727187696 167 VDVGQEPACVKTCPTGAIHFGTKEAMKQVAADRVSelnTRGY 208
Cdd:NF038355 142 IAEGKLPLCAEMCSTKALLAGDAEVVADIYRERVV---ARGA 180
NarH_like cd16365
beta FeS subunits DMSOR NarH-like family; This subfamily contains beta FeS subunits of several ...
 29-180 1.39e-19

beta FeS subunits DMSOR NarH-like family; This subfamily contains beta FeS subunits of several DMSO reductase superfamily, including nitrate reductase A, ethylbenzene dehydrogenase and selenate reductase. DMSO Reductase (DMSOR) family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. . The beta subunits of DMSOR contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system. Nitrate reductase A contains three subunits (the catalytic subunit NarG, the catalytic subunit NarH with four [Fe-S] clusters, and integral membrane subunit NarI) and often forms a respiratory chain with the formate dehydrogenase via the lipid soluble quinol pool. Ethylbenzene dehydrogenase oxidizes the hydrocarbon ethylbenzene to (S)-1-phenylethanol. Selenate reductase catalyzes reduction of selenate to selenite in bacterial species that can obtain energy by respiring anaerobically with selenate as the terminal electron acceptor.


Pssm-ID: 319887 [Multi-domain]  Cd Length: 201  Bit Score: 84.56  E-value: 1.39e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  29 EVAKLIDVTTCIGCKACQVACSEWNDIRDEVGH----NVGVYdnPADLTAKSWTVmrfSEVEENGKLEWLIR-KDGCMHC 103
Cdd:cd16365    2 QFAAVFNLNKCIGCQTCTVACKNAWTYRKGQEYmwwnNVETK--PGGGYPQDWEV---KTIDNGGNTRFFFYlQRLCNHC 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 727187696 104 ADPGCLKACPSEGAIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYKCTLCVDRVDVGQEPACVKTCP 180
Cdd:cd16365   77 TNPACLAACPRGAIYKREEDGIVLIDQKRCRGYRKCVEQCPYKKIYFNGLSRVSEKCIACYPRIEGGDPTRCMSACV 153
DMSOR_beta_like cd16367
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 33-185 4.86e-19

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319889 [Multi-domain]  Cd Length: 138  Bit Score: 81.58  E-value: 4.86e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  33 LIDVTTCIGCKACQVACSEWNDIRDEVGHNVGVYDNpadltakswtvmrfseveengkleWLIrKDGCMHCADPGCLKAC 112
Cdd:cd16367   15 VIDLDRCIRCDNCEKACADTHDGHSRLDRNGLRFGN------------------------LLV-PTACRHCVDPVCMIGC 69

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727187696 113 PsEGAIIQYANGIVdFQSEHCIGCGYCIAGCPFDVPRMNKDDnrvyKCTLCVDRVDvgqePACVKTCPTGAIH 185
Cdd:cd16367   70 P-TGAIHRDDGGEV-VISDACCGCGNCASACPYGAIQMVRAV----KCDLCAGYAG----PACVSACPTGAAI 132
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 39-199 6.42e-19

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 86.72  E-value: 6.42e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  39 CIGCKACQVACSewndirdeVGHNVGVY-DNPADLTAKswtVMRFSEVEENGKLEwlirkdgCMHCADPGCLKACPSeGA 117
Cdd:PRK12769  12 CLGCHACEIACV--------MAHNDEQHvLSQHHFHPR---ITVIKHQQQRSAVT-------CHHCEDAPCARSCPN-GA 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696 118 IIQYANGIVDFQsEHCIGCGYCIAGCPFDVPRM-------NKDDNRVYKCTLCVDRvdvGQEPACVKTCPTGAIHFGTKE 190
Cdd:PRK12769  73 ISHVDDSIQVNQ-QKCIGCKSCVVACPFGTMQIvltpvaaGKVKATAHKCDLCAGR---ENGPACVENCPADALQLVTEQ 148


                 ....*....
gi 727187696 191 AMKQVAADR 199
Cdd:PRK12769 149 ALSGMAKSR 157
EBDH_beta cd10555
beta subunit of ethylbenzene-dehydrogenase (EBDH); This subfamily includes ethylbenzene ...
 100-187 7.04e-18

beta subunit of ethylbenzene-dehydrogenase (EBDH); This subfamily includes ethylbenzene dehydrogenase (EBDH, EC 1.17.99.2), a member of the DMSO reductase family. EBDH oxidizes the hydrocarbon ethylbenzene to (S)-1-phenylethanol. It is a heterotrimer, with the alpha subunit containing the catalytic center with a molybdenum held by two molybdopterin-guanine dinucleotides, the beta subunit containing four iron-sulfur clusters (the electron transfer subunit) and the gamma subunit containing a methionine and a lysine as axial heme ligands. During catalysis, electrons produced by substrate oxidation are transferred to a heme in the gamma subunit and then presumably to a separate cytochrome involved in nitrate respiration.


Pssm-ID: 319877 [Multi-domain]  Cd Length: 316  Bit Score: 81.97  E-value: 7.04e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696 100 CMHCADPGCLKACPSeGAIIQYA-NGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYKCTLCVDRVDVGQEPACVKT 178
Cdd:cd10555  133 CNHCTNPACLAACPR-KAIYKREeDGIVLVDQDRCRGYRYCVEACPYKKIYFNPVEQKSEKCIFCYPRIEKGVAPACARQ 211


                 ....*....
gi 727187696 179 CPTGAIHFG 187
Cdd:cd10555  212 CVGRIRFVG 220
PRK09898 PRK09898
ferredoxin-like protein;
39-185 1.27e-16

ferredoxin-like protein;


Pssm-ID: 182135 [Multi-domain]  Cd Length: 208  Bit Score: 76.80  E-value: 1.27e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  39 CIGCKACQVACSEWND-------IRDEVGHNVGVYDNpadltakswtvmrfsEVEENGKL--EWLIRKDGCMHCADPGCL 109
Cdd:PRK09898  68 CTGCHRCEISCTNFNDgsvgtffSRIKIHRNYFFGDN---------------GVGSGGGLygDLNYTADTCRQCKEPQCM 132

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727187696 110 KACPSEGAIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYKCTLCvdrvdvgqePACVKTCPTGAIH 185
Cdd:PRK09898 133 NVCPIGAITWQQKEGCITVDHKRCIGCSACTTACPWMMATVNTESKKSSKCVLC---------GECANACPTGALK 199
PRK12809 PRK12809
putative oxidoreductase Fe-S binding subunit; Reviewed
 35-199 1.63e-16

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183762 [Multi-domain]  Cd Length: 639  Bit Score: 79.68  E-value: 1.63e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  35 DVTTCIGCKACQVACS------EW----NDIRDEVgHNVGvYDNPADLTAkswtvmrfseveengklewlirkdgCMHCA 104
Cdd:PRK12809   8 EAAECIGCHACEIACAvahnqeNWplshSDFRPRI-HVVG-KGQAANPVA-------------------------CHHCN 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696 105 DPGCLKACPSEGAIiqYANGIVDFQSEHCIGCGYCIAGCPFDVPRMNkdDNRVYKCTLCVDRVDvGQEpACVKTCPTGAI 184
Cdd:PRK12809  61 NAPCVTACPVNALT--FQSDSVQLDEQKCIGCKRCAIACPFGVVEMV--DTIAQKCDLCNQRSS-GTQ-ACIEVCPTQAL 134

                        170
                 ....*....|....*
gi 727187696 185 HFGTKEAMKQVAADR 199
Cdd:PRK12809 135 RLMDDKGLQQIKVAR 149
NarH_beta-like cd10557
beta subunit of nitrate reductase A (NarH) and similar proteins; This subfamily includes ...
 100-179 2.53e-16

beta subunit of nitrate reductase A (NarH) and similar proteins; This subfamily includes nitrate reductase A, a member of the DMSO reductase family. The respiratory nitrate reductase complex (NarGHI) from E. coli is a heterotrimer, with the catalytic subunit (NarG) with a molybdo-bis (molybdopterin guanine dinucleotide) cofactor and an [Fe-S] cluster, the electron transfer subunit (NarH) with four [Fe-S] clusters, and the integral membrane subunit (NarI) with two b-type hemes. Nitrate reductase A often forms a respiratory chain with the formate dehydrogenase via the lipid soluble quinol pool. Electron transfer from formate to nitrate is coupled to proton translocation across the cytoplasmic membrane generating proton motive force by a redox loop mechanism. Demethylmenaquinol (DMKH2) has been shown to be a good substrate for NarGHI in nitrate respiration in E. coli.


Pssm-ID: 319879 [Multi-domain]  Cd Length: 363  Bit Score: 78.17  E-value: 2.53e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696 100 CMHCADPGCLKACPSeGAIIQYA-NGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYKCTLCVDRVDVGQEPACVKT 178
Cdd:cd10557  179 CNHCLNPACVAACPS-GAIYKREeDGIVLIDQDRCRGWRMCVSACPYKKVYYNWKTGKSEKCIFCYPRLEAGQPTVCSET 257


                 .
gi 727187696 179 C 179
Cdd:cd10557  258 C 258
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 32-184 1.19e-13

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 66.53  E-value: 1.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  32 KLIDVTTCIGCKACQVACSEwndirdEVGHNVGVydnpadltAKSwtVMRfseVEENGKLEWLIRKDGCMHCADPGCLKA 111
Cdd:cd16370    4 RVKDMERCIGCYSCMLACSR------RVHKSASL--------SKS--AIR---VRTRGGLEGGFTVVVCRACEDPPCAEA 64

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727187696 112 CPsEGAIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYKCTLCvdrvdvgqePACVKTCPTGAI 184
Cdd:cd16370   65 CP-TGALEPRKGGGVVLDKEKCIGCGNCVKACIVGAIFWDEETNKPIICIHC---------GYCARYCPHDVL 127
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 34-184 2.14e-13

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 65.82  E-value: 2.14e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  34 IDVTTCIGCKACQVACSE-WNDIRDevghnvgvydnpadlTAKSwtVMRFSEVEENGKLewlirkDGCMHCADpgCLKAC 112
Cdd:cd16372    5 TDPEKCIGCLQCEEACSKtFFKEED---------------REKS--CIRITETEGGYAI------NVCNQCGE--CIDVC 59

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727187696 113 PsEGAIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYKCTLCvdrvdvgqePACVKTCPTGAI 184
Cdd:cd16372   60 P-TGAITRDANGVVMINKKLCVGCLMCVGFCPEGAMFKHEDYPEPFKCIAC---------GICVKACPTGAL 121
NarY COG1140
Nitrate reductase beta subunit [Energy production and conversion, Inorganic ion transport and ...
 100-179 7.02e-13

Nitrate reductase beta subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440755 [Multi-domain]  Cd Length: 485  Bit Score: 68.68  E-value: 7.02e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696 100 CMHCADPGCLKACPSeGAIIQYA-NGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYKCTLCVDRVDVGQEPACVKT 178
Cdd:COG1140  182 CEHCLNPACVASCPS-GAIYKREeDGIVLVDQDKCRGWRMCVSGCPYKKVYFNWKTGKAEKCIFCYPRIEAGQPTVCSET 260


                 .
gi 727187696 179 C 179
Cdd:COG1140  261 C 261
PRK10330 PRK10330
electron transport protein HydN;
33-199 6.83e-12

electron transport protein HydN;


Pssm-ID: 182382 [Multi-domain]  Cd Length: 181  Bit Score: 62.99  E-value: 6.83e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  33 LIDVTTCIGCKACQVACSewndirdeVGHNVGvyDNPADLTAKSWT----VMRFSEVEENGKlewlirkdgCMHCADPGC 108
Cdd:PRK10330   6 IADASKCIGCRTCEVACV--------VSHQEN--QDCASLTPETFLprihVIKGVNVSTATV---------CRQCEDAPC 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696 109 LKACPSeGAIIQyANGIVDFQSEHCIGCGYCIAGCPFDV------PRMNK---------DDNRVYKCTLCVDRVDvgqEP 173
Cdd:PRK10330  67 ANVCPN-GAISR-DKGFVHVMQERCIGCKTCVVACPYGAmevvvrPVIRNsgaglnvraEKAEANKCDLCNHRED---GP 141

                        170       180
                 ....*....|....*....|....*.
gi 727187696 174 ACVKTCPTGAIHFGTKEAMKQVAADR 199
Cdd:PRK10330 142 ACMAACPTHALICVDRNKLEQLSAEK 167
SER_beta cd10556
Beta subunit of selenate reductase; This subfamily includes beta FeS subunit of selenate ...
 21-180 3.21e-11

Beta subunit of selenate reductase; This subfamily includes beta FeS subunit of selenate reductase (SER), a member of the DMSO reductase family. SER catalyzes the reduction of selenate to selenite in bacterial species that can obtain energy by respiring anaerobically with selenate as the terminal electron acceptor. The enzyme comprises three subunits SerABC, forming a heterotrimer, with the catalytic component (alpha-subunit), iron-sulfur protein (beta-subunit) and monomeric b-type heme-containing gamma subunit. Beta subunit contains coordinating one [3Fe-4S] cluster and three [4Fe-4S] clusters and functions as electron carrier.


Pssm-ID: 319878 [Multi-domain]  Cd Length: 287  Bit Score: 62.48  E-value: 3.21e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  21 PRARDHQeeVAKLIDVTTCIGCKACQVACSE------------WNDIRDE------VGHNVGVYDNPADLT---AKSWTV 79
Cdd:cd10556    5 ESRPDKQ--FAMVFDTNKCIACQTCTMACKStwtsgkgqeymwWNNVETKpyggypLGWDVRLLDEEGGQTwaeGGVYEG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  80 MRFSEVEENGK---------LEW---LIRKDG--------------------------CMHCADPGCLKACPSEGAIIQY 121
Cdd:cd10556   83 KTIFEAAAAGEqvlgyrpedEDWrypNIGEDEvngertpdtgsslpphpiwffylpriCNHCTYPACLAACPRKAIYKRE 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 727187696 122 ANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYKCTLCVDRVDVGQEPACVKTCP 180
Cdd:cd10556  163 EDGIVLIDQERCRGYRECVEACPYKKPMYNPTTRVSEKCIGCYPRIEEGDQTQCVSACI 221
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 121-191 2.45e-08

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 50.11  E-value: 2.45e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 727187696 121 YANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRV---YKCTLCVdrvdvgqepACVKTCPTGAIHFGTKEA 191
Cdd:COG1149    1 VKRKIPVIDEEKCIGCGLCVEVCPEGAIKLDDGGAPVvdpDLCTGCG---------ACVGVCPTGAITLEEREA 65
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 96-185 7.43e-08

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 52.30  E-value: 7.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  96 RKDGCMHCADpgCLKACPSeGAIIQYANGI--VDfqSEHCIGCGYCIAGCPFDVPRMNKDDNRVYKCTL---CVDRVDVG 170
Cdd:COG2878  135 CEYGCIGCGD--CIKACPF-DAIVGAAKGMhtVD--EDKCTGCGLCVEACPVDCIEMVPVSPTVVVSSWdkgKAVRKVVG 209

                         90
                 ....*....|....*
gi 727187696 171 QEPACVKTCPTGAIH 185
Cdd:COG2878  210 CIGLCCKKCCPAAAI 224
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
95-185 7.90e-08

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 53.11  E-value: 7.90e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  95 IRKDGCMHCADPGCLKACPSEG----AIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVY--KCTLCvdrvd 168
Cdd:COG4624   51 CPRCCLCCCCCCRCCVAISCIQvrgiIIIDKRGPSIIRDKEKCKNCYPCVRACPVKAIKVDDGKAEIDeeKCISC----- 125

                         90
                 ....*....|....*..
gi 727187696 169 vGQepaCVKTCPTGAIH 185
Cdd:COG4624  126 -GQ---CVAVCPFGAIT 138
NapF COG1145
Ferredoxin [Energy production and conversion];
84-191 2.26e-07

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 50.88  E-value: 2.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  84 EVEENGKLEWLIRKDGCMHCADPGCLKACPSEGAIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVY----K 159
Cdd:COG1145  135 IAAALAEAGLAILGAAAPVDALAISGGKKIEEELKIAIKKAKAVIDAEKCIGCGLCVKVCPTGAIRLKDGKPQIVvdpdK 214

                         90       100       110
                 ....*....|....*....|....*....|..
gi 727187696 160 CTLCvdrvdvgqePACVKTCPTGAIHFGTKEA 191
Cdd:COG1145  215 CIGC---------GACVKVCPVGAISLEPKEI 237
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 127-188 5.13e-07

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 47.78  E-value: 5.13e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 727187696 127 DFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVY-------KCTLCvdrvdvGqepACVKTCPTGAIHFGT 188
Cdd:cd10549    2 KYDPEKCIGCGICVKACPTDAIELGPNGAIARgpeidedKCVFC------G---ACVEVCPTGAIELTP 61
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
131-192 7.24e-07

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 45.88  E-value: 7.24e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 727187696 131 EHCIGCGYCIAGCPFDVPRMNKDDNRV--YKCTLCvdrvdvgqePACVKTCPTGAIHFGTKEAM 192
Cdd:COG2768   11 EKCIGCGACVKVCPVGAISIEDGKAVIdpEKCIGC---------GACIEVCPVGAIKIEWEEDE 65
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 131-194 8.60e-07

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 45.47  E-value: 8.60e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 727187696 131 EHCIGCGYCIAGCPFDVPRMNKDDNRVY-----KCTLCvdrvdvgqePACVKTCPTGAIHFGTKEAMKQ 194
Cdd:COG1146    8 DKCIGCGACVEVCPVDVLELDEEGKKALvinpeECIGC---------GACELVCPVGAITVEDDEPEEQ 67
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 97-185 1.32e-06

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 46.62  E-value: 1.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  97 KDGCMHCADpgCLKACPSeGAIIQYANGIV----DFQSEHCIGCGYCIAGCPFDVPRMNKDdnrvYKCTLCVDRVDVGQE 172
Cdd:cd10549    5 PEKCIGCGI--CVKACPT-DAIELGPNGAIargpEIDEDKCVFCGACVEVCPTGAIELTPE----GKEYVPKEKEAEIDE 77

                         90
                 ....*....|....*....
gi 727187696 173 P------ACVKTCPTGAIH 185
Cdd:cd10549   78 EkcigcgLCVKVCPVDAIT 96
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
99-185 1.45e-06

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 48.78  E-value: 1.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  99 GCMHCADpgCLKACPSEGAIIQyaNGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYkcTLCVDRvDVGQE------ 172
Cdd:PRK07118 140 GCLGLGS--CVAACPFDAIHIE--NGLPVVDEDKCTGCGACVKACPRNVIELIPKSARVF--VACNSK-DKGKAvkkvce 212

                         90
                 ....*....|....*....
gi 727187696 173 ------PACVKTCPTGAIH 185
Cdd:PRK07118 213 vgcigcGKCVKACPAGAIT 231
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
125-189 2.40e-06

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 47.75  E-value: 2.40e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727187696 125 IVDFQSEHCIGCGYCIAGCPFD-VPRMNKDDNrvYKCTLCVDrvdvgqepaCVKTCPTGAIHFGTK 189
Cdd:COG0348  204 RVRYDRGDCIDCGLCVKVCPMGiDIRKGEINQ--SECINCGR---------CIDACPKDAIRFSSR 258
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 131-190 2.83e-06

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 43.97  E-value: 2.83e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727187696 131 EHCIGCGYCIAGCPFDVPRMNKDDNRVY------KCTLCVdrvdvgqepACVKTCPTGAIHFGTKE 190
Cdd:COG1143    2 DKCIGCGLCVRVCPVDAITIEDGEPGKVyvidpdKCIGCG---------LCVEVCPTGAISMTPFE 58
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
94-154 4.46e-06

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 43.95  E-value: 4.46e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727187696  94 LIRKDGCMHCADpgCLKACPsEGAIIQyANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDD 154
Cdd:COG2768    7 YVDEEKCIGCGA--CVKVCP-VGAISI-EDGKAVIDPEKCIGCGACIEVCPVGAIKIEWEE 63
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
131-197 4.91e-06

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 47.55  E-value: 4.91e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727187696 131 EHCIGCGYCIAGCPFDVPRMNKDDNRVY---KCTLCvdrvdvGqepACVKTCPTGAI---HFGTKEAMKQVAA 197
Cdd:COG1148  496 EKCTGCGRCVEVCPYGAISIDEKGVAEVnpaLCKGC------G---TCAAACPSGAIslkGFTDDQILAQIDA 559
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 130-189 5.17e-06

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 46.78  E-value: 5.17e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727187696 130 SEHCIGCGYCIAGCPFDVPRMnkDDNRVY---KCTLCVdrvdvgqepACVKTCPTGAIHFGTK 189
Cdd:NF038196 184 TDKCIGCGICAKVCPVNNIEM--EDGKPVwghNCTHCL---------ACIHRCPKEAIEYGKK 235
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 93-144 6.52e-06

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 43.01  E-value: 6.52e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 727187696   93 WLIRKDGCMHCADpgCLKACPSEGAI-----IQYANGIVDFQSEHCIGCGYCIAGCP 144
Cdd:pfam13237   2 VVIDPDKCIGCGR--CTAACPAGLTRvgaivERLEGEAVRIGVWKCIGCGACVEACP 56
Fer4_9 pfam13187
4Fe-4S dicluster domain;
133-184 8.15e-06

4Fe-4S dicluster domain;


Pssm-ID: 463801 [Multi-domain]  Cd Length: 50  Bit Score: 42.54  E-value: 8.15e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 727187696  133 CIGCGYCIAGCPFDV------PRMNKDDNRVYKCTLCVdrvdvgqepACVKTCPTGAI 184
Cdd:pfam13187   2 CTGCGACVAACPAGAivpdlvGQTIRGDIAGLACIGCG---------ACVDACPRGAI 50
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 34-147 1.01e-05

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 44.31  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  34 IDVTTCIGCKACQVACsewndirdevghnvgvydnPADltAKSWTVMRFSEVEENGKLEwlIRKDGCMHCADpgCLKACP 113
Cdd:cd10549   37 IDEDKCVFCGACVEVC-------------------PTG--AIELTPEGKEYVPKEKEAE--IDEEKCIGCGL--CVKVCP 91

                         90       100       110
                 ....*....|....*....|....*....|....
gi 727187696 114 sEGAIIQYANGIVDFQSEHCIGCGYCIAGCPFDV 147
Cdd:cd10549   92 -VDAITLEDELEIVIDKEKCIGCGICAEVCPVNA 124
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 89-147 1.35e-05

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 42.35  E-value: 1.35e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 727187696  89 GKLEWLIRKDGCMHCADpgCLKACPsEGAIiQYANGIVDFQSEHCIGCGYCIAGCPFDV 147
Cdd:COG2221    6 GTWPPKIDEEKCIGCGL--CVAVCP-TGAI-SLDDGKLVIDEEKCIGCGACIRVCPTGA 60
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
133-202 3.44e-05

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 44.54  E-value: 3.44e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 727187696 133 CIGCGYCIAGCPFDVPRMnkDDNRVY----KCTLCvdrvdvgqePACVKTCPTGAIHFGTKEAMKQVAADRVSE 202
Cdd:PRK07118 215 CIGCGKCVKACPAGAITM--ENNLAVidqeKCTSC---------GKCVEKCPTKAIRILNKPPKVKEPKKAAAE 277
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 95-146 3.47e-05

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 41.25  E-value: 3.47e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 727187696  95 IRKDGCMHCADpgCLKACPsEGAIIQYANGIVDFQSEHCIGCGYCIAGCPFD 146
Cdd:COG1149    8 IDEEKCIGCGL--CVEVCP-EGAIKLDDGGAPVVDPDLCTGCGACVGVCPTG 56
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 117-185 4.65e-05

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 40.80  E-value: 4.65e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727187696 117 AIIQYANGIVDfqSEHCIGCGYCIAGCPFDVPRMnkDDNRVY----KCTLCvdrvdvgqePACVKTCPTGAIH 185
Cdd:COG2221    3 GIIGTWPPKID--EEKCIGCGLCVAVCPTGAISL--DDGKLVideeKCIGC---------GACIRVCPTGAIK 62
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
91-147 4.96e-05

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 43.90  E-value: 4.96e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 727187696  91 LEWLIRKDGCMHCADpgCLKACPsEGAIIqyANGIVDfQSEhCIGCGYCIAGCPFDV 147
Cdd:COG0348  203 LRVRYDRGDCIDCGL--CVKVCP-MGIDI--RKGEIN-QSE-CINCGRCIDACPKDA 252
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
133-191 7.44e-05

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 43.38  E-value: 7.44e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727187696 133 CIGCGYCIAGCPFD-------VPRMNKDdnrvyKCTLCvdrvdvgqePACVKTCPTGAIHFGTKEA 191
Cdd:PRK07118 141 CLGLGSCVAACPFDaihiengLPVVDED-----KCTGC---------GACVKACPRNVIELIPKSA 192
Fer COG1141
Ferredoxin [Energy production and conversion];
133-185 1.28e-04

Ferredoxin [Energy production and conversion];


Pssm-ID: 440756 [Multi-domain]  Cd Length: 63  Bit Score: 39.48  E-value: 1.28e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 727187696 133 CIGCGYCIAGCPfDVPRMNKDDnrvyKCTLCVDRVDVGQEPAC---VKTCPTGAIH 185
Cdd:COG1141   10 CIGCGLCVALAP-EVFELDDDG----KAVVLDEEVPEELEEDVreaADACPVGAIT 60
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 95-146 1.91e-04

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 39.26  E-value: 1.91e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 727187696  95 IRKDGCMHCADpgCLKACPsEGAIIQYANGIVDFQSEHCIGCGYCIAGCPFD 146
Cdd:COG1144   27 VDEDKCIGCGL--CWIVCP-DGAIRVDDGKYYGIDYDYCKGCGICAEVCPVK 75
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
84-145 1.93e-04

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 42.71  E-value: 1.93e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 727187696  84 EVEENGKLEWLIRKDGCMHCADPG-------CLKACPSEgaIIQYANGIVDFQSEHCIGCGYCIAGCPF 145
Cdd:COG4624   68 ISCIQVRGIIIIDKRGPSIIRDKEkckncypCVRACPVK--AIKVDDGKAEIDEEKCISCGQCVAVCPF 134
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 131-184 2.03e-04

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 39.26  E-value: 2.03e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 727187696 131 EHCIGCGYCIAGCPFDVPRMNKDDNRV--YKCTLCVdrvdvgqepACVKTCPTGAI 184
Cdd:COG4231   22 DKCTGCGACVKVCPADAIEEGDGKAVIdpDLCIGCG---------SCVQVCPVDAI 68
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 133-183 2.48e-04

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 38.28  E-value: 2.48e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 727187696  133 CIGCGYCIAGCPFDVPRMNKDDNRVYKCTLCVDRVDVGQEPACVKTCPTGA 183
Cdd:pfam12838   1 CIGCGACVAACPVGAITLDEVGEKKGTKTVVIDPERCVGCGACVAVCPTGA 51
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 127-193 2.75e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 40.70  E-value: 2.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696 127 DFQSeHCIGCGYCIAGCPFDV---------------PRMnkdDNRVYKCTLCVDrvdvgqepACVKTCPTGAIHFGTKEA 191
Cdd:cd16373   11 EFLA-LCIRCGLCVEACPTGViqpagledgleggrtPYL---DPREGPCDLCCD--------ACVEVCPTGALRPLDLEE 78


                 ..
gi 727187696 192 MK 193
Cdd:cd16373   79 QK 80
flavo_MJ0208 TIGR02700
archaeoflavoprotein, MJ0208 family; This model describes one of two paralogous families of ...
 90-146 6.14e-04

archaeoflavoprotein, MJ0208 family; This model describes one of two paralogous families of archaealflavoprotein. The other, described by TIGR02699 and typified by the partially characterized AF1518 of Archaeoglobus fulgidus, is a homodimeric FMN-containing flavoprotein that accepts electrons from ferredoxin and can transfer them to various oxidoreductases. The function of this protein family is unknown. [Unknown function, General]


Pssm-ID: 131747 [Multi-domain]  Cd Length: 234  Bit Score: 40.63  E-value: 6.14e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 727187696   90 KLEWLIRKDGCMHCADpgCLKACPSEGaiIQYANGIVDFQSEHCIGCGYCIAGCPFD 146
Cdd:TIGR02700 140 ITPYMIDRKRCKGCGI--CVDACPRSA--IDMVDGKAFIRLLKCVGCGKCKEACPYN 192
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 100-147 6.46e-04

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 37.12  E-value: 6.46e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 727187696  100 CMHCADpgCLKACPS-----EGAIIQYANGIVDFQSEHCIGCGYCIAGCPFDV 147
Cdd:pfam12838   1 CIGCGA--CVAACPVgaitlDEVGEKKGTKTVVIDPERCVGCGACVAVCPTGA 51
rnfB TIGR01944
electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in ...
 94-146 1.58e-03

electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the B subunit. [Energy metabolism, Electron transport]


Pssm-ID: 273887 [Multi-domain]  Cd Length: 165  Bit Score: 38.63  E-value: 1.58e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 727187696   94 LIRKDGCMHCADpgCLKACPSEgAIIQYANGIVDFQSEHCIGCGYCIAGCPFD 146
Cdd:TIGR01944 109 LIDEDNCIGCTK--CIQACPVD-AIVGAAKAMHTVIADECTGCDLCVEPCPTD 158
PRK13795 PRK13795
hypothetical protein; Provisional
 94-144 1.69e-03

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 39.98  E-value: 1.69e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 727187696  94 LIRKDGCMHCadpG-CLKACPsEGAI-IQYANGIVDFQSEHCIGCGYCIAGCP 144
Cdd:PRK13795 577 LRRAAECVGC---GvCVGACP-TGAIrIEEGKRKISVDEEKCIHCGKCTEVCP 625
Fer4_13 pfam13370
4Fe-4S single cluster domain of Ferredoxin I; Fer4_13 is a ferredoxin I from sulfate-reducing ...
 126-185 1.80e-03

4Fe-4S single cluster domain of Ferredoxin I; Fer4_13 is a ferredoxin I from sulfate-reducing bacteria. Chemical sequence analysis suggests that this characteriztic [4Fe-4S] cluster sulfur environment is widely distributed among ferredoxins.


Pssm-ID: 433153 [Multi-domain]  Cd Length: 58  Bit Score: 36.13  E-value: 1.80e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727187696  126 VDFQSehCIGCGYCIAGCPfDVPRMNKDDNRVYkctlcVDRVDVGQ-EPACVK----TCPTGAIH 185
Cdd:pfam13370   1 VDEDT--CIDCGTCRELAP-EVFKYDDDGGASF-----VHDQPVNEeEEDLAEealdSCPVEAIG 57
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 98-186 2.04e-03

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 37.61  E-value: 2.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  98 DGCMHCADpgCLKACPsEGAIIQYANGI--VDFQSEHCIGCGYCIAGCPFDVPRMNKDD---------------NRVYkC 160
Cdd:cd10564   13 DLCTRCGD--CVEACP-EGIIVRGDGGFpeLDFSRGECTFCGACAEACPEGALDPAREApwplraeigdsclalQGVE-C 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 727187696 161 TLCVD-----------RVDVGQEP-----------ACVKTCPTGAIHF 186
Cdd:cd10564   89 RSCQDacptqairfrpRLGGIALPeldadactgcgACVSVCPVGAITL 136
PRK08348 PRK08348
NADH-plastoquinone oxidoreductase subunit; Provisional
 124-185 3.13e-03

NADH-plastoquinone oxidoreductase subunit; Provisional


Pssm-ID: 181399 [Multi-domain]  Cd Length: 120  Bit Score: 36.74  E-value: 3.13e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727187696 124 GIVDFQSEHCIGCGYCIAGCPFDV----PRMNKDDNRVYKCTLCvdrvdvGQepaCVKTCPTGAIH 185
Cdd:PRK08348  35 GKILYDVDKCVGCRMCVTVCPAGVfvylPEIRKVALWTGRCVFC------GQ---CVDVCPTGALQ 91
PorD_KorD TIGR02179
2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; A number ...
 95-150 3.20e-03

2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; A number of anaerobic and microaerophilic species lack pyruvate dehydrogenase and have instead a four subunit, oxygen-sensitive pyruvate oxidoreductase, with either ferredoxins or flavodoxins used as the acceptor. Several related four-subunit enzymes may exist in the same species. This model describes a subfamily of delta subunits, representing mostly pyruvate, 2-ketoisovalerate, and 2-oxoglutarate specific enzymes. The delta subunit is the smallest and resembles ferredoxins.


Pssm-ID: 131234 [Multi-domain]  Cd Length: 78  Bit Score: 35.77  E-value: 3.20e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 727187696   95 IRKDGCMHCADpgCLKACPsEGAIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRM 150
Cdd:TIGR02179  22 VDKEKCIKCKN--CWLYCP-EGAIQEDEGGFVGIDYDYCKGCGICANVCPVKAIEM 74
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 97-159 3.79e-03

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 35.49  E-value: 3.79e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727187696  97 KDGCMHCADpgCLKACPSeGAIIQYANG---IVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNRVYK 159
Cdd:COG1143    1 EDKCIGCGL--CVRVCPV-DAITIEDGEpgkVYVIDPDKCIGCGLCVEVCPTGAISMTPFELAVED 63
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 95-156 4.62e-03

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 35.40  E-value: 4.62e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727187696  95 IRKDGCMHCADpgCLKACPSEgaIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDDNR 156
Cdd:COG4231   19 IDEDKCTGCGA--CVKVCPAD--AIEEGDGKAVIDPDLCIGCGSCVQVCPVDAIKLEKRVPE 76
vorD PRK09623
3-methyl-2-oxobutanoate dehydrogenase subunit delta;
94-154 5.60e-03

3-methyl-2-oxobutanoate dehydrogenase subunit delta;


Pssm-ID: 170016 [Multi-domain]  Cd Length: 105  Bit Score: 35.69  E-value: 5.60e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727187696  94 LIRKDGCMHCADpgCLKACPsEGAIIQYANGIVDFQSEHCIGCGYCIAGCPFDVPRMNKDD 154
Cdd:PRK09623  47 VVDESKCVKCYI--CWKFCP-EPAIYIKEDGYVAIDYDYCKGCGICANECPTKAITMVKEE 104
PRK00783 PRK00783
DNA-directed RNA polymerase subunit D; Provisional
 130-185 7.59e-03

DNA-directed RNA polymerase subunit D; Provisional


Pssm-ID: 234837 [Multi-domain]  Cd Length: 263  Bit Score: 37.17  E-value: 7.59e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 727187696 130 SEHCIGCGYCIAGCPFDVPRMNKDDNRV---YKCTLCvdrvdvgqePACVKTCPTGAIH 185
Cdd:PRK00783 168 SEDCDECEKCVEACPRGVLELKEGKLVVtdlLNCSLC---------KLCERACPGKAIR 217
porD PRK09625
pyruvate flavodoxin oxidoreductase subunit delta; Reviewed
 97-144 8.01e-03

pyruvate flavodoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 236596 [Multi-domain]  Cd Length: 133  Bit Score: 35.88  E-value: 8.01e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 727187696  97 KDGCMHCADpgCLKACPsEGAIIQYANGIVDFQSEHCIGCGYCIAGCP 144
Cdd:PRK09625  58 NEICINCFN--CWVYCP-DAAILSRDKKLKGVDYSHCKGCGVCVEVCP 102
PRK13409 PRK13409
ribosome biogenesis/translation initiation ATPase RLI;
108-146 8.74e-03

ribosome biogenesis/translation initiation ATPase RLI;


Pssm-ID: 184037 [Multi-domain]  Cd Length: 590  Bit Score: 37.48  E-value: 8.74e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 727187696 108 CLKACP-----SEGAIIQYANGIVDFQSEHCIGCGYCIAGCPFD 146
Cdd:PRK13409  21 CIKYCPvvrtgEETIEIDEDDGKPVISEELCIGCGICVKKCPFD 64
COG1453 COG1453
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
57-148 9.08e-03

Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];


Pssm-ID: 441062 [Multi-domain]  Cd Length: 365  Bit Score: 37.11  E-value: 9.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187696  57 DEVGHNVGVYDNPADLTAKSWTVMRfSEVEENGKLEwlirKDGCMHCAdpGCLKaCPSE---GAIIQYAN-----GIVDF 128
Cdd:COG1453  245 EQLDENLKTADNLEPLTEEELAILE-RLAEELGELL----KDFCTGCG--YCMP-CPQGiniPEVFRLYNlarayGMREY 316

                         90       100       110
                 ....*....|....*....|....*....|..
gi 727187696 129 QSEH------------CIGCGYCIAGCPFDVP 148
Cdd:COG1453  317 AKERynalgpgakasaCIECGACEERCPQGLD 348
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH