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Conserved domains on  [gi|727187860|ref|WP_033649693|]
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MULTISPECIES: UTRA domain-containing protein [Serratia]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
phnR super family cl31335
phosphonate utilization transcriptional regulator PhnR; This family of proteins are members of ...
 11-236 2.60e-90

phosphonate utilization transcriptional regulator PhnR; This family of proteins are members of the GntR family (pfam00392) containing an N-terminal helix-turn-helix (HTH) motif. This clade is found adjacent to or inside of operons for the degradation of 2-aminoethylphosphonate (AEP) in Salmonella, Vibrio Aeromonas hydrophila, Hahella chejuensis and Psychromonas ingrahamii. [Regulatory functions, DNA interactions]


The actual alignment was detected with superfamily member TIGR03337:

Pssm-ID: 132380 [Multi-domain]  Cd Length: 231  Bit Score: 265.53  E-value: 2.60e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187860   11 ICQTLNARIAAGEFAVGGKLPSERALSEQFATTRITLQEALGQLEAQGVIYRQVRRGWFISPPRLIYNPLQRSHFHAMAQ 90
Cdd:TIGR03337   6 IKDHLSYQIRAGALLPGDKLPSERDLGERFNTTRVTIREALQQLEAEGLIYREDRRGWFVSPPRLRYNPTRTQNFHEYVR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187860   91 QQGRAAHTEAIDSAVVTLDAPLAGRLALPPGAEAYRIRRLRYIDGRAVLYCEHYLNPAYFPGILDEDLTQSLTALYAARY 170
Cdd:TIGR03337  86 EQGREPKTELIGVTVTPAPARMAELLQLQPFDRLFLLQRLRYADGRPVCYCENYILPARVPGLLKEDLNGSLTEIYRNHY 165

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727187860  171 GIHYGRVRFDMLPTLLPQQAAAMLKVTYGSPALFITRVNRDQHDRVIDCDLEYWRYDALHIDVEAQ 236
Cdd:TIGR03337 166 GLVYHSMNLRFKPTALLEEAAQALGATAGLPALHLERTNYDQHGRVLDLDIEYWRHDALTIEVDTN 231
 
Name Accession Description Interval E-value
phnR TIGR03337
phosphonate utilization transcriptional regulator PhnR; This family of proteins are members of ...
 11-236 2.60e-90

phosphonate utilization transcriptional regulator PhnR; This family of proteins are members of the GntR family (pfam00392) containing an N-terminal helix-turn-helix (HTH) motif. This clade is found adjacent to or inside of operons for the degradation of 2-aminoethylphosphonate (AEP) in Salmonella, Vibrio Aeromonas hydrophila, Hahella chejuensis and Psychromonas ingrahamii. [Regulatory functions, DNA interactions]


Pssm-ID: 132380 [Multi-domain]  Cd Length: 231  Bit Score: 265.53  E-value: 2.60e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187860   11 ICQTLNARIAAGEFAVGGKLPSERALSEQFATTRITLQEALGQLEAQGVIYRQVRRGWFISPPRLIYNPLQRSHFHAMAQ 90
Cdd:TIGR03337   6 IKDHLSYQIRAGALLPGDKLPSERDLGERFNTTRVTIREALQQLEAEGLIYREDRRGWFVSPPRLRYNPTRTQNFHEYVR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187860   91 QQGRAAHTEAIDSAVVTLDAPLAGRLALPPGAEAYRIRRLRYIDGRAVLYCEHYLNPAYFPGILDEDLTQSLTALYAARY 170
Cdd:TIGR03337  86 EQGREPKTELIGVTVTPAPARMAELLQLQPFDRLFLLQRLRYADGRPVCYCENYILPARVPGLLKEDLNGSLTEIYRNHY 165

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727187860  171 GIHYGRVRFDMLPTLLPQQAAAMLKVTYGSPALFITRVNRDQHDRVIDCDLEYWRYDALHIDVEAQ 236
Cdd:TIGR03337 166 GLVYHSMNLRFKPTALLEEAAQALGATAGLPALHLERTNYDQHGRVLDLDIEYWRHDALTIEVDTN 231
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
11-234 7.07e-71

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 216.65  E-value: 7.07e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187860  11 ICQTLNARIAAGEFAVGGKLPSERALSEQFATTRITLQEALGQLEAQGVIYRQVRRGWFISPPRLIYNPLQRSHFHAMAQ 90
Cdd:COG2188   10 IADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTSFTEELR 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187860  91 QQGRAAHTEAIDSAVVTLDAPLAGRLALPPGAEAYRIRRLRYIDGRAVLYCEHYLNPAYFPGILDEDL-TQSLTALYAAR 169
Cdd:COG2188   90 ARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLeTGSLYELLEER 169

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727187860 170 YGIHYGRVRFDMLPTLLPQQAAAMLKVTYGSPALFITRVNRDQHDRVIDCDLEYWRYDALHIDVE 234
Cdd:COG2188  170 YGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVE 234
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 91-230 1.57e-38

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 130.79  E-value: 1.57e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187860   91 QQGRAAHTEAIDSAVVTLDAPLAGRLALPPGAEAYRIRRLRYIDGRAVLYCEHYLNPAYFPGILDEDLTQ-SLTALYAAR 169
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLEEgSLYDYLEER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727187860  170 YGIHYGRVRFDMLPTLLPQQAAAMLKVTYGSPALFITRVNRDQHDRVIDCDLEYWRYDALH 230
Cdd:pfam07702  81 YGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 91-228 3.57e-34

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 119.71  E-value: 3.57e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187860    91 QQGRAAHTEAIDSAVVTLDAPLAGRLALPPGAEAYRIRRLRYIDGRAVLYCEHYLNPAYFPGILDEDLTQSLTALYAARY 170
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEERL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727187860   171 GIH---YGRVRFDMLPTLLPQQAAAMLKVTYGSPALFITRVNRDQHDRVIDCDLEYWRYDA 228
Cdd:smart00866  81 GLKivrSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDR 141
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 11-71 6.52e-18

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 74.79  E-value: 6.52e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727187860  11 ICQTLNARIAAGEFAVGGKLPSERALSEQFATTRITLQEALGQLEAQGVIYRQVRRGWFIS 71
Cdd:cd07377    6 IADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
PRK11402 PRK11402
transcriptional regulator PhoB;
9-227 1.23e-17

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 78.72  E-value: 1.23e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187860   9 ATICQTLNARIAAGEFAVGGKLPSERALSEQFATTRITLQEALGQLEAQGVIYRQVRRGWFISPPRLIYNPLQRSHFHAM 88
Cdd:PRK11402  12 ATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLTVSGFTDF 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187860  89 AQQQGRAAHTEAIDSAVVTlDAPLAGRLALPPGAEAYRIRRLRYIDGRAVLYCEHYLNPAYFPGIlDEDLTQSltalyAA 168
Cdd:PRK11402  92 GVSQGKATKEKVIEQERVS-AAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDF-DEIYVEG-----SS 164

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727187860 169 RYGIHygRVRFDMLPT----LL-----PQQAAAMLKVTYGSPALFITRVNRDQHDRVIDCDLEYWRYD 227
Cdd:PRK11402 165 TYQLF--QERFDTRVVsdkkTIdifaaTRPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRAN 230
 
Name Accession Description Interval E-value
phnR TIGR03337
phosphonate utilization transcriptional regulator PhnR; This family of proteins are members of ...
 11-236 2.60e-90

phosphonate utilization transcriptional regulator PhnR; This family of proteins are members of the GntR family (pfam00392) containing an N-terminal helix-turn-helix (HTH) motif. This clade is found adjacent to or inside of operons for the degradation of 2-aminoethylphosphonate (AEP) in Salmonella, Vibrio Aeromonas hydrophila, Hahella chejuensis and Psychromonas ingrahamii. [Regulatory functions, DNA interactions]


Pssm-ID: 132380 [Multi-domain]  Cd Length: 231  Bit Score: 265.53  E-value: 2.60e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187860   11 ICQTLNARIAAGEFAVGGKLPSERALSEQFATTRITLQEALGQLEAQGVIYRQVRRGWFISPPRLIYNPLQRSHFHAMAQ 90
Cdd:TIGR03337   6 IKDHLSYQIRAGALLPGDKLPSERDLGERFNTTRVTIREALQQLEAEGLIYREDRRGWFVSPPRLRYNPTRTQNFHEYVR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187860   91 QQGRAAHTEAIDSAVVTLDAPLAGRLALPPGAEAYRIRRLRYIDGRAVLYCEHYLNPAYFPGILDEDLTQSLTALYAARY 170
Cdd:TIGR03337  86 EQGREPKTELIGVTVTPAPARMAELLQLQPFDRLFLLQRLRYADGRPVCYCENYILPARVPGLLKEDLNGSLTEIYRNHY 165

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727187860  171 GIHYGRVRFDMLPTLLPQQAAAMLKVTYGSPALFITRVNRDQHDRVIDCDLEYWRYDALHIDVEAQ 236
Cdd:TIGR03337 166 GLVYHSMNLRFKPTALLEEAAQALGATAGLPALHLERTNYDQHGRVLDLDIEYWRHDALTIEVDTN 231
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
11-234 7.07e-71

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 216.65  E-value: 7.07e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187860  11 ICQTLNARIAAGEFAVGGKLPSERALSEQFATTRITLQEALGQLEAQGVIYRQVRRGWFISPPRLIYNPLQRSHFHAMAQ 90
Cdd:COG2188   10 IADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTSFTEELR 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187860  91 QQGRAAHTEAIDSAVVTLDAPLAGRLALPPGAEAYRIRRLRYIDGRAVLYCEHYLNPAYFPGILDEDL-TQSLTALYAAR 169
Cdd:COG2188   90 ARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLeTGSLYELLEER 169

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727187860 170 YGIHYGRVRFDMLPTLLPQQAAAMLKVTYGSPALFITRVNRDQHDRVIDCDLEYWRYDALHIDVE 234
Cdd:COG2188  170 YGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVE 234
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 91-230 1.57e-38

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 130.79  E-value: 1.57e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187860   91 QQGRAAHTEAIDSAVVTLDAPLAGRLALPPGAEAYRIRRLRYIDGRAVLYCEHYLNPAYFPGILDEDLTQ-SLTALYAAR 169
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLEEgSLYDYLEER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727187860  170 YGIHYGRVRFDMLPTLLPQQAAAMLKVTYGSPALFITRVNRDQHDRVIDCDLEYWRYDALH 230
Cdd:pfam07702  81 YGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 91-228 3.57e-34

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 119.71  E-value: 3.57e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187860    91 QQGRAAHTEAIDSAVVTLDAPLAGRLALPPGAEAYRIRRLRYIDGRAVLYCEHYLNPAYFPGILDEDLTQSLTALYAARY 170
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEERL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727187860   171 GIH---YGRVRFDMLPTLLPQQAAAMLKVTYGSPALFITRVNRDQHDRVIDCDLEYWRYDA 228
Cdd:smart00866  81 GLKivrSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDR 141
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 11-71 6.52e-18

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 74.79  E-value: 6.52e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727187860  11 ICQTLNARIAAGEFAVGGKLPSERALSEQFATTRITLQEALGQLEAQGVIYRQVRRGWFIS 71
Cdd:cd07377    6 IADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
PRK11402 PRK11402
transcriptional regulator PhoB;
9-227 1.23e-17

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 78.72  E-value: 1.23e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187860   9 ATICQTLNARIAAGEFAVGGKLPSERALSEQFATTRITLQEALGQLEAQGVIYRQVRRGWFISPPRLIYNPLQRSHFHAM 88
Cdd:PRK11402  12 ATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLTVSGFTDF 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187860  89 AQQQGRAAHTEAIDSAVVTlDAPLAGRLALPPGAEAYRIRRLRYIDGRAVLYCEHYLNPAYFPGIlDEDLTQSltalyAA 168
Cdd:PRK11402  92 GVSQGKATKEKVIEQERVS-AAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDF-DEIYVEG-----SS 164

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727187860 169 RYGIHygRVRFDMLPT----LL-----PQQAAAMLKVTYGSPALFITRVNRDQHDRVIDCDLEYWRYD 227
Cdd:PRK11402 165 TYQLF--QERFDTRVVsdkkTIdifaaTRPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRAN 230
PRK09764 PRK09764
GntR family transcriptional regulator;
11-203 6.02e-16

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 74.09  E-value: 6.02e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187860  11 ICQTLNARIAAGEFAVGGKLPSERALSEQFATTRITLQEALGQLEAQGVIYRQVRRGWFISPPRLIYNPLQRSHFHAMAQ 90
Cdd:PRK09764  10 IADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQLTSFDEKLS 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187860  91 QQGRAAHTEAIDSAVVTLDAPLAGRLALPPGAEAYRIRRLRYIDGRAVLYCEHYLNPAYFPGILDEDLTQSLTALYAARY 170
Cdd:PRK09764  90 DRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENSKYHFIEEVK 169

                        170       180       190
                 ....*....|....*....|....*....|...
gi 727187860 171 GIHYGRVRFDMLPTLLPQQAAAMLKVTYGSPAL 203
Cdd:PRK09764 170 KMVIDRSEQEIIPLMPTEEMSRLLNISQTKPIL 202
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 7-70 5.98e-15

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 67.25  E-value: 5.98e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 727187860    7 TVATICQTLNARIAAGEFAVGGKLPSERALSEQFATTRITLQEALGQLEAQGVIYRQVRRGWFI 70
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
11-70 8.20e-15

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 66.44  E-value: 8.20e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187860    11 ICQTLNARIAAGEFAVGGKLPSERALSEQFATTRITLQEALGQLEAQGVIYRQVRRGWFI 70
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
3-74 6.16e-14

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 68.42  E-value: 6.16e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727187860   3 EAPTTVATICQTLNARIAAGEFAVGGKLPSERALSEQFATTRITLQEALGQLEAQGVIYRQVRRGWFISPPR 74
Cdd:COG2186    4 RRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPS 75
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 11-173 1.87e-12

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 66.01  E-value: 1.87e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187860  11 ICQTLNARIAAGEFAVGGKLPSERALSEQFATTRITLQEALGQLEAQGVIYRQVRRGWFISP--PRLIYNPLQRSHFHAM 88
Cdd:COG1167   17 LADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAArlPAPAPAPRAAAAVAAP 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187860  89 AQQQGRAAHTEAIDSAVVTLDAPLAGRLALppgAEAYRiRRLRYIDGRAVLYCEHylnpayfPGilDEDLTQSLtALYAA 168
Cdd:COG1167   97 ALRRLLEAAPGVIDLGSGAPDPDLFPLAAL---RRALR-RALRRLPPALLGYGDP-------QG--LPELREAI-ARYLA 162


                 ....*
gi 727187860 169 RYGIH 173
Cdd:COG1167  163 RRGVP 167
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
11-72 1.45e-10

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 56.73  E-value: 1.45e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727187860  11 ICQTLNARIAAGEFAVGGKLPSERALSEQFATTRITLQEALGQLEAQGVIYRQVRRGWFISP 72
Cdd:COG1725   15 IADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAE 76
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
1-73 4.47e-08

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 51.85  E-value: 4.47e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727187860   1 MSEAPTTVATICQTLNARIAAGEFAVGGKLpSERALSEQFATTRITLQEALGQLEAQGVIYRQVRRGWFISPP 73
Cdd:COG1802    6 PLRRESLAEQVYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPL 77
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 1-145 6.19e-07

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 48.62  E-value: 6.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187860   1 MSEAPTTVATICQTLNARIAA---GEFAVGGKLPSERALSEQFATTRITLQEALGQLEAQGVIYRqvRRGWFISPPRLIY 77
Cdd:PRK10079   3 LSRHPTSYPTRYQEIAAKLEQelrQHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQR--RQGVGVLVLMRPY 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187860  78 N-PLQ-RSHFHAMAQQQGRAAHTEAIDSAVVTLDAPLAGRLALPPGAEAYRIRRLRYIDGRAVLYCEHYL 145
Cdd:PRK10079  81 DyPLNaQARFSQNLLDQGSHPTSEKLLSVLRPASGHVADALGITEGENVIHLRTLRRVNGVALCLIDHYF 150
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
10-71 3.76e-06

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 46.55  E-value: 3.76e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727187860  10 TICQTLNARIAAGEFAVGGKLPSERALSEQFATTRITLQEALGQLEAQGVIYRQVRRGWFIS 71
Cdd:PRK09464  14 VIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQ 75
PRK11523 PRK11523
transcriptional regulator ExuR;
15-67 4.65e-06

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 46.38  E-value: 4.65e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 727187860  15 LNARIAAGEFAVGGKLPSERALSEQFATTRITLQEALGQLEAQGviYRQVRRG 67
Cdd:PRK11523  17 LKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEG--YVEVRKG 67
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 11-80 1.38e-05

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 44.76  E-value: 1.38e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727187860  11 ICQTLNARIAAGEFAVGGKLPSERALSEQFATTRITLQEALGQLEAQGVIYRQVRRGWFISPP------RLIYNPL 80
Cdd:PRK10421   7 VADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWRhetwseQNIVQPL 82
PRK14999 PRK14999
histidine utilization repressor; Provisional
 10-169 8.84e-05

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 42.61  E-value: 8.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187860  10 TICQTLNARIAAGEFAVGGKLPSERALSEQFATTRITLQEALGQLEAQGVIYRQVRRGWFISPP---------RLIYNPL 80
Cdd:PRK14999  16 TVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPkgqsalfevRSIAEEI 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727187860  81 -QRSHFHamaqqqgraaHTEAIDSAVVTLDAPLAGRLALPPGAEAYRIRRLRYIDGRAVLYCEHYLNPAYFPGILDEDLT 159
Cdd:PRK14999  96 aARRHQH----------RCEVLTLERVRANAIQASALNVNESDVIFHSIMVHYENDLPVQIEDRCVNADIAVDYLTQDYR 165

                        170
                 ....*....|
gi 727187860 160 QSLTALYAAR 169
Cdd:PRK14999 166 QTTPHAYLSR 175
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 15-60 1.77e-04

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 41.55  E-value: 1.77e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 727187860  15 LNARIAAGEFAVGGKLPSERALSEQFATTRITLQEALGQLEAQGVI 60
Cdd:PRK03837  22 LEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLV 67
PRK10225 PRK10225
Uxu operon transcriptional regulator;
19-67 8.89e-04

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 39.62  E-value: 8.89e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 727187860  19 IAAGEFAVGGKLPSERALSEQFATTRITLQEALGQLEAQGVIyrQVRRG 67
Cdd:PRK10225  22 IIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLV--EVRRG 68
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 1-72 4.35e-03

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 37.44  E-value: 4.35e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727187860   1 MSEAPTTVA-TICQTLNARIAAGEFAVGGKLPSERALSEQFATTRITLQEALGQLEAQGVIYRQVRRGWFISP 72
Cdd:PRK09990   1 MKDERRPIAdVVAERIERLIVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVAR 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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