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Conserved domains on  [gi|727192479|ref|WP_033654243|]
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CD3337/EF1877 family mobilome membrane protein, partial [Enterococcus sp. HMSC063C12]

Protein Classification

SLC5/6 family protein( domain architecture ID 124)

SLC5/6 (solute carrier 5/6) family protein may function as a transporter

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SLC5-6-like_sbd super family cl00456
Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the ...
 6-156 7.86e-05

Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporters or solute sodium symporters), SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporters or Na+/Cl--dependent transporters), and nucleobase-cation-symport-1 (NCS1) transporters. SLC5s co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. SLC6s include Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin, dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. Members of this superfamily are important in human physiology and disease. They contain a functional core of 10 transmembrane helices (TMs): an inverted structural repeat, TMs1-5 and TMs6-10; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT.


The actual alignment was detected with superfamily member pfam01490:

Pssm-ID: 444915  Cd Length: 410  Bit Score: 44.60  E-value: 7.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727192479    6 TKTMNRLGTVVFLV-----LFNIGISFFVFllTGIML------------FSQILFIIfaMFLPISFLLSMLPTYESLGkk 68
Cdd:pfam01490  76 YRLLGPKGRLLILFaillnLFGVCISYLIF--AGDNLpaifdsffdtcpISLVYFII--IFGLIFIPLSFIPNLSALS-- 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727192479   69 aIIRLFNTIMMRAGVTLVITTAFSIST---MFFNISATYPFFMVAflQIVTFAG-IYFKLGDIMNMFNLQSNdsqsmgrr 144
Cdd:pfam01490 150 -ILSLLAAVSSLYYIVILVLSVAEGIVltaQGVGHLGSKTNIKLA--GTFLAIGiIVFAFEGHAVLLPIQNE-------- 218

                         170
                  ....*....|..
gi 727192479  145 vMRKPQMLMNRT 156
Cdd:pfam01490 219 -MKNPSKFKAMT 229
 
Name Accession Description Interval E-value
Aa_trans pfam01490
Transmembrane amino acid transporter protein; This transmembrane region is found in many amino ...
 6-156 7.86e-05

Transmembrane amino acid transporter protein; This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.


Pssm-ID: 279788  Cd Length: 410  Bit Score: 44.60  E-value: 7.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727192479    6 TKTMNRLGTVVFLV-----LFNIGISFFVFllTGIML------------FSQILFIIfaMFLPISFLLSMLPTYESLGkk 68
Cdd:pfam01490  76 YRLLGPKGRLLILFaillnLFGVCISYLIF--AGDNLpaifdsffdtcpISLVYFII--IFGLIFIPLSFIPNLSALS-- 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727192479   69 aIIRLFNTIMMRAGVTLVITTAFSIST---MFFNISATYPFFMVAflQIVTFAG-IYFKLGDIMNMFNLQSNdsqsmgrr 144
Cdd:pfam01490 150 -ILSLLAAVSSLYYIVILVLSVAEGIVltaQGVGHLGSKTNIKLA--GTFLAIGiIVFAFEGHAVLLPIQNE-------- 218

                         170
                  ....*....|..
gi 727192479  145 vMRKPQMLMNRT 156
Cdd:pfam01490 219 -MKNPSKFKAMT 229
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
6-112 3.15e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 39.45  E-value: 3.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727192479   6 TKTMNRLGTVVFLVLFNIGisfFVFLLTGIML----------FSQILFIIFAMFlpISFLLSMLPTyeslGKkaIIRLFN 75
Cdd:COG0738    3 KKNYRRALIAIYLLFFLWG---FATALWGPLIpalkdafglsDAQAGLLLFAFF--LGYLLASLPA----GR--LIDRFG 71

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 727192479  76 T-IMMRAGVTLVITTAFSIStmffnISATYPFFMVAFL 112
Cdd:COG0738   72 YkRGLLLGLLLMALGLLLFA-----LAPSYPLLLLALF 104
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 9-124 4.32e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 38.95  E-value: 4.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727192479   9 MNRLGTVVFLVLFNIGISFFVFLLTGIMLFSQILF--IIFAMFLPISFLLSMLPTYESLGKKAIIRLFNTIMMRAGVTLV 86
Cdd:cd06174   55 ADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLgrFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGI 134

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 727192479  87 ITTAF-SISTMFFNISATYPFFMVAFLQIVTFAGIYFKL 124
Cdd:cd06174  135 LGPLLgGILASSLGFGWRAVFLIAAALALLAAILLLLVV 173
 
Name Accession Description Interval E-value
Aa_trans pfam01490
Transmembrane amino acid transporter protein; This transmembrane region is found in many amino ...
 6-156 7.86e-05

Transmembrane amino acid transporter protein; This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.


Pssm-ID: 279788  Cd Length: 410  Bit Score: 44.60  E-value: 7.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727192479    6 TKTMNRLGTVVFLV-----LFNIGISFFVFllTGIML------------FSQILFIIfaMFLPISFLLSMLPTYESLGkk 68
Cdd:pfam01490  76 YRLLGPKGRLLILFaillnLFGVCISYLIF--AGDNLpaifdsffdtcpISLVYFII--IFGLIFIPLSFIPNLSALS-- 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727192479   69 aIIRLFNTIMMRAGVTLVITTAFSIST---MFFNISATYPFFMVAflQIVTFAG-IYFKLGDIMNMFNLQSNdsqsmgrr 144
Cdd:pfam01490 150 -ILSLLAAVSSLYYIVILVLSVAEGIVltaQGVGHLGSKTNIKLA--GTFLAIGiIVFAFEGHAVLLPIQNE-------- 218

                         170
                  ....*....|..
gi 727192479  145 vMRKPQMLMNRT 156
Cdd:pfam01490 219 -MKNPSKFKAMT 229
FUSC_2 pfam13515
Fusaric acid resistance protein-like;
36-130 1.37e-03

Fusaric acid resistance protein-like;


Pssm-ID: 433273 [Multi-domain]  Cd Length: 126  Bit Score: 38.38  E-value: 1.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727192479   36 MLFSQILFIIFAMFLPISFLLSMLPTYESLGKKAIIRLFNTImmrAGV--------------TLVITTAFSISTMFFNIS 101
Cdd:pfam13515   3 ALIAELLGLPRGYWAPIAAAIVLQPTLGATLRRAVQRILGTV---LGVllgllllallpgplQLILVVALLGFLAEYLIG 79

                          90       100
                  ....*....|....*....|....*....
gi 727192479  102 ATYPFFMVAFLQIVTFAGIYFKLGDIMNM 130
Cdd:pfam13515  80 RNYALAQVFVTPLALLLASLAGGGGPPEL 108
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
6-112 3.15e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 39.45  E-value: 3.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727192479   6 TKTMNRLGTVVFLVLFNIGisfFVFLLTGIML----------FSQILFIIFAMFlpISFLLSMLPTyeslGKkaIIRLFN 75
Cdd:COG0738    3 KKNYRRALIAIYLLFFLWG---FATALWGPLIpalkdafglsDAQAGLLLFAFF--LGYLLASLPA----GR--LIDRFG 71

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 727192479  76 T-IMMRAGVTLVITTAFSIStmffnISATYPFFMVAFL 112
Cdd:COG0738   72 YkRGLLLGLLLMALGLLLFA-----LAPSYPLLLLALF 104
7TMR-DISM_7TM pfam07695
7TM diverse intracellular signalling; This entry represents the transmembrane region of the ...
 17-121 4.27e-03

7TM diverse intracellular signalling; This entry represents the transmembrane region of the 7TM-DISM (7TM Receptors with Diverse Intracellular Signalling Modules).


Pssm-ID: 429600 [Multi-domain]  Cd Length: 207  Bit Score: 38.41  E-value: 4.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727192479   17 FLVLFNIGISFFVFLLTGIML----------FSQILFIIFAMFLPISFLL----SMLPTYESLGKkaIIRLFNtIMMRAG 82
Cdd:pfam07695  33 YYVLYLLSFLLYQLSLNGLGFqylwpnappwLNNKLLYLSLLLLLPFFALlfarSFLELKKYLPR--LLRLLL-GLALLL 109

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 727192479   83 VTLVITTAFSISTMFFNIsatYPFFMVAFLQIVTFAGIY 121
Cdd:pfam07695 110 ALLLLLLPLFPYTLSLPL---AQLLALLFILFLLLLGII 145
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 9-124 4.32e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 38.95  E-value: 4.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727192479   9 MNRLGTVVFLVLFNIGISFFVFLLTGIMLFSQILF--IIFAMFLPISFLLSMLPTYESLGKKAIIRLFNTIMMRAGVTLV 86
Cdd:cd06174   55 ADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLgrFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGI 134

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 727192479  87 ITTAF-SISTMFFNISATYPFFMVAFLQIVTFAGIYFKL 124
Cdd:cd06174  135 LGPLLgGILASSLGFGWRAVFLIAAALALLAAILLLLVV 173
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 15-120 6.03e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 38.69  E-value: 6.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727192479  15 VVFLVLFNIGISFFVFLLtgimlfsqILFIIFAMFLpiSFLLSMLPTYESLGKKAIIRLFNTIMMRAGVTLVITTAFSIS 94
Cdd:cd17478  139 AAALVALFGGLGLLILLI--------IPGLAVALLL--LRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRS 208

                         90       100
                 ....*....|....*....|....*.
gi 727192479  95 TMFFNISATYPFFMVAFLQIVTFAGI 120
Cdd:cd17478  209 WVLSSLTTFLPFYLVQRGYSLVFAGL 234
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
10-122 7.03e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 38.34  E-value: 7.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727192479  10 NRLGTV--VFLVLFNIGISFFVFLLTGIMLFS-----QILFIIFAMFLPISFLLSML-------PTYESLGKKAIIRLF- 74
Cdd:COG2211  146 TRLSSWrfAFAGLGGLLASVLPPPLVAAFGGDaalgyRLTALIFAVLGLLAFLLTFFgtkerpvPEEEKVSLKESLKALl 225

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 727192479  75 -NTIMMR-AGVTLVITTAFSISTMFFNISATY---------PFFMVAFlQIVTFAGIYF 122
Cdd:COG2211  226 kNRPFLLlLLAYLLFFLALALVAALLLYYFKYvlglsaalvGLLLALY-FLAALLGAPL 283
ABC-2_lan_permease cd21503
lantibiotic immunity ABC transporter permease (also called ABC-2 transporter permease) subunit; ...
 9-132 9.88e-03

lantibiotic immunity ABC transporter permease (also called ABC-2 transporter permease) subunit; This family contains lantibiotic ABC transporter permease subunits which are highly hydrophobic, integral membrane proteins, and part of the bacitracin ABC transport system that confers resistance to the Gram-positive bacteria in which this system operates, particularly to type-A lantibiotics. Lantibiotics are small peptides, produced by Gram-positive bacteria, which are ribosomally-synthesized as pre-peptides and act by disrupting membrane integrity. Genes encoding the lantibiotic ABC transporter subunits are highly organized in operons containing all the genes required for maturation, transport, immunity, and synthesis. For example, in Lactococcus lactis, the lantibiotic nisin is active against other Gram-positive bacteria via various modes of actions; however, its self-protection against the pore-forming nisin is mediated by the ABC transporter composed of NisF, NisE and NisG subunits. This family includes the Lactococcus lactis NisG permease subunit that transports nisin to the surface and expels it from the membrane. This family also includes the lantibiotic ABC transporter permease subunits EpiE, MutE, MutG, and SlvE. Self-protection of the epidermin-producing strain Staphylococcus epidermidis Tu3298 against the pore-forming lantibiotic epidermin is mediated by an ABC transporter composed of the EpiF, EpiE, and EpiG proteins. In the mutacin I-producing strain Streptococcus mutans CH43, self-immunity against mutacin I is mediated by proteins MutF, MutE, and MutG, while in salivaricin D-producing strain Streptococcus salivarius 5M6c, mediation is via ABC transporter proteins SlvF, SlvE, and SlvG.


Pssm-ID: 409631  Cd Length: 221  Bit Score: 37.28  E-value: 9.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727192479   9 MNRLGTVVFLVLFNIGISFFVFL--LTGIMLFSQILFI---IFAMFLP--ISFLLSMLPTYESL-GKKAIIRLF----NT 76
Cdd:cd21503    6 TKRTPFRVLLILFPILFALILSLyiGFTNSLKGVSIFSfftIYNILLPflISLLIPLLYEQEEQaGNFQNILRSghsrKK 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727192479  77 IMMRAGVTLVITTAFSIstmFFNISATYPFFMVAFLQIVTFAG-----IYFKLGDIMNMFN 132
Cdd:cd21503   86 IFLSKFLFITLLLLLVI---LLLSLPFILIWLITGIGNITIILflltlIGTITSLPIIPLY 143
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 12-109 9.90e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 37.98  E-value: 9.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727192479  12 LGTVVFLVLFNIGISFfVFLLTGIMLFsqILFIIFAMFLPISFllsmlPTYESLGKKAIIRLFNTIMMRAGVTLVITTAF 91
Cdd:cd17329  139 IGPLLGGLLLLYSFRL-LFLAAAVLFL--LAALVLLFLLPETR-----PKRRAAEKTEILRGYKIVLRDRAFLLFLLASF 210

                         90
                 ....*....|....*...
gi 727192479  92 SISTMFFNISATYPFFMV 109
Cdd:cd17329  211 LISLIYFQLESTLPVYVV 228
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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