sigma-E factor negative regulatory protein [Stenotrophomonas maltophilia]
Protein Classification
sigma-E factor negative regulatory protein( domain architecture ID 11611353)
sigma-E factor negative regulatory protein similar to anti-sigma-E factor RseA that functions as the anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE); ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| RseA_N | cd16328 | N-terminal domain of RseA; This family contains the cytoplasmic (N-terminal) domain of RseA, ... |
25-82 | 1.41e-18 | ||
N-terminal domain of RseA; This family contains the cytoplasmic (N-terminal) domain of RseA, the transmembrane anti-sigma-E factor. RseA is degraded during sigma-E-dependent transcription caused by bacterial envelope stress such as heat shock. It is an inner membrane protein with an N-terminal cytoplasmic domain that binds sigma-E and blocks its transcriptional activity, and a C-terminal periplasmic domain that binds RseB, an auxiliary negative regulator. Under inducing conditions, RseA is rapidly degraded and sigma-E is released into the cytoplasm, where it can bind core RNAP and induce its regulon. It has been shown that just the N-terminal domain is sufficient to bind and inhibit sigma-E. The C-terminal domain may interact with other proteins that signal periplasmic stress. : Pssm-ID: 319992 Cd Length: 65 Bit Score: 77.62 E-value: 1.41e-18
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| Name | Accession | Description | Interval | E-value | ||
| RseA_N | cd16328 | N-terminal domain of RseA; This family contains the cytoplasmic (N-terminal) domain of RseA, ... |
25-82 | 1.41e-18 | ||
N-terminal domain of RseA; This family contains the cytoplasmic (N-terminal) domain of RseA, the transmembrane anti-sigma-E factor. RseA is degraded during sigma-E-dependent transcription caused by bacterial envelope stress such as heat shock. It is an inner membrane protein with an N-terminal cytoplasmic domain that binds sigma-E and blocks its transcriptional activity, and a C-terminal periplasmic domain that binds RseB, an auxiliary negative regulator. Under inducing conditions, RseA is rapidly degraded and sigma-E is released into the cytoplasm, where it can bind core RNAP and induce its regulon. It has been shown that just the N-terminal domain is sufficient to bind and inhibit sigma-E. The C-terminal domain may interact with other proteins that signal periplasmic stress. Pssm-ID: 319992 Cd Length: 65 Bit Score: 77.62 E-value: 1.41e-18
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| RseA | COG3073 | RseA, negative regulator of sigma E activity [Signal transduction mechanisms]; |
21-82 | 6.24e-15 | ||
RseA, negative regulator of sigma E activity [Signal transduction mechanisms]; Pssm-ID: 442307 Cd Length: 166 Bit Score: 70.78 E-value: 6.24e-15
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| RseA_N | pfam03872 | Anti sigma-E protein RseA, N-terminal domain; Sigma-E is important for the induction of ... |
25-82 | 1.25e-08 | ||
Anti sigma-E protein RseA, N-terminal domain; Sigma-E is important for the induction of proteins involved in heat shock response. RseA binds sigma-E via its N-terminal domain, sequestering sigma-E and preventing transcription from heat-shock promoters. The C-terminal domain is located in the periplasm, and may interact with other protein that signal periplasmic stress. Pssm-ID: 427557 Cd Length: 87 Bit Score: 51.11 E-value: 1.25e-08
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| Name | Accession | Description | Interval | E-value | ||
| RseA_N | cd16328 | N-terminal domain of RseA; This family contains the cytoplasmic (N-terminal) domain of RseA, ... |
25-82 | 1.41e-18 | ||
N-terminal domain of RseA; This family contains the cytoplasmic (N-terminal) domain of RseA, the transmembrane anti-sigma-E factor. RseA is degraded during sigma-E-dependent transcription caused by bacterial envelope stress such as heat shock. It is an inner membrane protein with an N-terminal cytoplasmic domain that binds sigma-E and blocks its transcriptional activity, and a C-terminal periplasmic domain that binds RseB, an auxiliary negative regulator. Under inducing conditions, RseA is rapidly degraded and sigma-E is released into the cytoplasm, where it can bind core RNAP and induce its regulon. It has been shown that just the N-terminal domain is sufficient to bind and inhibit sigma-E. The C-terminal domain may interact with other proteins that signal periplasmic stress. Pssm-ID: 319992 Cd Length: 65 Bit Score: 77.62 E-value: 1.41e-18
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| RseA | COG3073 | RseA, negative regulator of sigma E activity [Signal transduction mechanisms]; |
21-82 | 6.24e-15 | ||
RseA, negative regulator of sigma E activity [Signal transduction mechanisms]; Pssm-ID: 442307 Cd Length: 166 Bit Score: 70.78 E-value: 6.24e-15
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| RseA_N | pfam03872 | Anti sigma-E protein RseA, N-terminal domain; Sigma-E is important for the induction of ... |
25-82 | 1.25e-08 | ||
Anti sigma-E protein RseA, N-terminal domain; Sigma-E is important for the induction of proteins involved in heat shock response. RseA binds sigma-E via its N-terminal domain, sequestering sigma-E and preventing transcription from heat-shock promoters. The C-terminal domain is located in the periplasm, and may interact with other protein that signal periplasmic stress. Pssm-ID: 427557 Cd Length: 87 Bit Score: 51.11 E-value: 1.25e-08
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| RsiW | COG5662 | Transmembrane transcriptional regulator RsiW (anti-sigma-W factor) [Transcription]; |
21-78 | 7.98e-04 | ||
Transmembrane transcriptional regulator RsiW (anti-sigma-W factor) [Transcription]; Pssm-ID: 444381 [Multi-domain] Cd Length: 155 Bit Score: 39.06 E-value: 7.98e-04
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