|
Name |
Accession |
Description |
Interval |
E-value |
| CusA |
COG3696 |
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism]; |
1-1047 |
0e+00 |
|
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 1494.91 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 1 MIARIIRFSIANRVFVLLAALILAAWGTWAVKNTPVDALPDLSDVQVIIRTNFSGQAPQIVENQVTYPLTTTMLSVPGVK 80
Cdd:COG3696 1 MLNRIIRFSLRNRLLVLLLTLLLAAAGIYSLRRLPIDAFPDITNVQVQVITEAPGLSPEEVEQQVTYPIETALNGLPGVK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 81 TVRGYSFFGDSFVYVIFDEHTDLYWARSRVLEYLNQIQGKMPANAKSSLGPDATGVGWVYEYALVDPTGQHDLSELRSIQ 160
Cdd:COG3696 81 EVRSISRFGLSVVTVIFEDGTDIYWARQLVLERLQQVREQLPAGVTPELGPISTGLGEIYQYTLESDPGKYSLMELRTLQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 161 DWFLKYELKTLPNVAEVATIGGMVKQYQVVLDPSKMATLGVTQNNVIEAIQKANQETGGSVLEMAETEYMVRASGYLKTL 240
Cdd:COG3696 161 DWVIRPQLRSVPGVAEVNSFGGFVKQYQVLVDPAKLRAYGLTLDDVIEALERNNANVGGGYIERGGQEYLVRGIGLIRSL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 241 DDFRQIPLRTNSfGVPVSLGDVATIQLGPEMRRGISELNGQGETVGGVVILRAGKNARETITAVKAKLAELQQSLPKGVQ 320
Cdd:COG3696 241 EDIENIVVKTRN-GTPVLLRDVAEVRIGPAPRRGAATLNGEGEVVGGIVLMLKGENALEVIEAVKAKLAELKPSLPEGVK 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 321 VVPVYDRSQLIDRAVENLSHKLIEEFIVVALVCGLFLWHLRSAMVAIVSLPLGILSAFLVMHYQGLNANIMSLGGIAIAI 400
Cdd:COG3696 320 IVPFYDRSDLIDRAIHTVTKNLLEGALLVILVLFLFLGNLRAALIVALAIPLSLLFAFIVMRLFGISANLMSLGGLAIDF 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 401 GAMVDAAIVMVENAHKHIETWQHEHpeqvlEAQVRWNIITRSASEVGPTLFFCLLIITLSFIPIFTLQAQEGRLFSPLAF 480
Cdd:COG3696 400 GIIVDGAVVMVENILRRLEENRAAG-----TPRERLEVVLEAAREVRRPIFFATLIIILVFLPIFTLEGVEGKLFRPMAL 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 481 TKTYAMAAAAGLSITLIPVLMGYWIRGKLPsEQRNPLNRFLIKIYSPMLDKVLAHPKTILLGALLIFLISLFPLTRLGGE 560
Cdd:COG3696 475 TVIFALLGALLLSLTLVPVLASLLLRGKVP-EKENPLVRWLKRLYRPLLRWALRHPKLVLAVALVLLVLALALFPRLGSE 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 561 FLPNMDEGDLLYMPSALPGLSAAKASELLQQTDRMIKTVPEVATVFGKAGRAESATDSAPLEMFETTIQFKPRSEWRSGM 640
Cdd:COG3696 554 FLPELDEGDLLVMATLPPGISLEESVELGQQVERILKSFPEVESVVSRTGRAEDATDPMGVNMSETFVILKPRSEWRSGR 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 641 TPDKLIKELDKAV-QVPGLTNIWVPPIRNRIDMLATGVKSPIGIKVSANDLQDIDRVAQQIEQVAKQVPGVSSALSERLT 719
Cdd:COG3696 634 TKEELIAEMREALeQIPGVNFNFSQPIQMRVDELLSGVRADVAVKIFGDDLDVLRRLAEQIEAVLKTVPGAADVQVERVT 713
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 720 GGRYVDVDINRMQAARYGLNIKDVQQIVSSAIGGENIGETVEGLARDPINVRYPREIRDSLEALRNLPILTESGQQIVLS 799
Cdd:COG3696 714 GLPQLDIRIDRDAAARYGLNVADVQDVVETAIGGKAVGQVYEGERRFDIVVRLPEELRDDPEAIRNLPIPTPSGAQVPLS 793
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 800 SVANIQITDGPPMLKSENARPSGWIYVDVQGRDLASVVQDLKQAIDQKVKRSSAMSISYSGQFEFMERANARLKVVIPIT 879
Cdd:COG3696 794 QVADIEVVEGPNQISRENGRRRIVVQANVRGRDLGSFVAEAQAKVAEQVKLPPGYYIEWGGQFENLQRATARLAIVVPLA 873
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 880 LMIIFLLLYLIFRQVQDAVLIMATLPFALIGGIWAMYLSDYHFSVAIAVGFIALAGVAAEFGVVMLFYLKQAIEHAqqsl 959
Cdd:COG3696 874 LLLIFLLLYLAFGSVRDALLILLNVPFALIGGVLALWLRGMPLSVSAGVGFIALFGVAVLNGVVLVSYINQLRAEG---- 949
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 960 ssstaslteQQLNKAIHTGAVLRVRPKAMTVAVILAGLIPILLGTGTGSELMSRIALPMVGGMISAPLLSMFVIPAAYQL 1039
Cdd:COG3696 950 ---------LDLREAIIEGALERLRPVLMTALVAALGLLPMALSTGPGSEVQRPLATVVIGGLITSTLLTLLVLPALYLL 1020
|
....*...
gi 727723773 1040 LIKRKLSK 1047
Cdd:COG3696 1021 FGRRRLRR 1028
|
|
| 2A0601 |
TIGR00914 |
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ... |
1-1044 |
0e+00 |
|
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 129992 [Multi-domain] Cd Length: 1051 Bit Score: 1314.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 1 MIARIIRFSIANRVFVLLAALILAAWGTWAVKNTPVDALPDLSDVQVIIRTNFSGQAPQIVENQVTYPLTTTMLSVPGVK 80
Cdd:TIGR00914 1 MIERIISFSVAQRWLVLLATLVMAILGIWSYNRLPIDAVPDITNVQVQINTSAPGYSPLEVEQRVTYPIETAMAGLPGLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 81 TVRGYSFFGDSFVYVIFDEHTDLYWARSRVLEYLNQIQGKMPANAKSSLGPDATGVGWVYEYALVDPTG-------QHDL 153
Cdd:TIGR00914 81 TTRSLSRYGLSQVTVIFKDGTDLYFARQLVNERLQQARDNLPEGVSPEMGPISTGLGEIFLYTVEAEEGarkkdggAYTL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 154 SELRSIQDWFLKYELKTLPNVAEVATIGGMVKQYQVVLDPSKMATLGVTQNNVIEAIQKANQETGGSVLEMAETEYMVRA 233
Cdd:TIGR00914 161 TDLRTIQDWIIRPQLRTVPGVAEVNSIGGYVKQFLVAPDPEKLAAYGLSLADVVNALERNNQNVGAGYIERRGEQYLVRA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 234 SGYLKTLDDFRQIPLRTnSFGVPVSLGDVATIQLGPEMRRGISELNGQgETVGGVVILRAGKNARETITAVKAKLAELQQ 313
Cdd:TIGR00914 241 PGQVQSMDDIRNIVIAT-GEGVPIRIRDVARVQIGKELRTGAATENGK-EVVLGTVFMLIGENSRTVAQAVGDKLETINK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 314 SLPKGVQVVPVYDRSQLIDRAVENLSHKLIEEFIVVALVCGLFLWHLRSAMVAIVSLPLGILSAFLVMHYQGLNANIMSL 393
Cdd:TIGR00914 319 TLPEGVEIVTTYDRSQLVDAAIATVKKNLLEGALLVIVILFLFLGNIRAALIAATVIPLSLLITFIGMVFQGISANLMSL 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 394 GgiAIAIGAMVDAAIVMVENAHKHIETWQHEHPEQvLEAQVRWNIITRSASEVGPTLFFCLLIITLSFIPIFTLQAQEGR 473
Cdd:TIGR00914 399 G--ALDFGLIVDGAVVIVENAHRRLAEAQHHHGRQ-LTLKERLHEVFAASREVRRPLIFGQLIITLVFLPIFTLTGVEGK 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 474 LFSPLAFTKTYAMAAAAGLSITLIPVLMGYWIRGKLPsEQRNPLNRFLIKIYSPMLDKVLAHPKTILLGALLIFLISLFP 553
Cdd:TIGR00914 476 MFHPMAFTVVLALAGAMILSLTFVPAAVALFIRGKVA-EKENRLMRVLKRRYEPLLERVLAWPAVVLGAAAVSIVLVVWI 554
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 554 LTRLGGEFLPNMDEGDLLYMPSALPGLSAAKASELLQQTDRMIKTVPEVATVFGKAGRAESATDSAPLEMFETTIQFKPR 633
Cdd:TIGR00914 555 ASRVGGEFIPSLNEGDLAYQALRIPGTSLAQSVAMQQTLEKLIKSFPEVARVFAKTGTAEIATDPMPPNASDTYIILKPE 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 634 SEWRSG--MTPDKLIKELDKAVQVPGLTNIWVPPIRNRIDMLATGVKSPIGIKVSANDLQDIDRVAQQIEQVAKQVPGVS 711
Cdd:TIGR00914 635 SQWPEGkkTKEDLIEEIQEATVRIPGNNYEFTQPIQMRFNELISGVRSDVAVKVFGDDLDDLDATAEKISAVLKGVPGAA 714
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 712 SALSERLTGGRYVDVDINRMQAARYGLNIKDVQQIVSSAIGGENIGETVEGLARDPINVRYPREIRDSLEALRNLPILTE 791
Cdd:TIGR00914 715 DVKVEQTTGLPYLTVEIDREKAARYGLTVGDVQDTVATAVGGRMSGETFEGDRRFDIVIRLPESLRESPQALRQLPIPLP 794
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 792 SG-----QQIVLSSVANIQITDGPPMLKSENARPSGWIYVDVQGRDLASVVQDLKQAIDQKVKRSSAMSISYSGQFEFME 866
Cdd:TIGR00914 795 LSedarkQFIPLSDVADLRVSPGPNQISRENGKRRVVVSANVRGRDLGSFVDDAKKAIAEQVKLPPGYWITWGGQFEQLQ 874
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 867 RANARLKVVIPITLMIIFLLLYLIFRQVQDAVLIMATLPFALIGGIWAMYLSDYHFSVAIAVGFIALAGVAAEFGVVMLF 946
Cdd:TIGR00914 875 SATKRLQIVVPVTLLLIFVLLYAAFGNVKDALLVFTGIPFALTGGVFALWLRGIPLSISAAVGFIALSGVAVLNGLVMIS 954
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 947 YLKQAIEHAQQslssstaslteqqLNKAIHTGAVLRVRPKAMTVAVILAGLIPILLGTGTGSELMSRIALPMVGGMISAP 1026
Cdd:TIGR00914 955 FIRKLLEEGPS-------------LDEAVYEGALTRVRPVLMTALVASLGFVPMAIATGTGAEVQRPLATVVIGGIITAT 1021
|
1050
....*....|....*...
gi 727723773 1027 LLSMFVIPAAYQLLIKRK 1044
Cdd:TIGR00914 1022 LLTLFVLPALYRLVHRRR 1039
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
5-1040 |
0e+00 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 720.23 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 5 IIRFSIANRVFVLLAALILAAWGTWAVKNTPVDALPDLSDVQVIIRTNFSGQAPQIVENQVTYPLTTTMLSVPGVKTVRG 84
Cdd:pfam00873 1 MSKFFIRRPIFTLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 85 YSFFGDSFVYVIFDEHTDLYWARSRVLEYLNQIQGKMPANAKS-SLGPDATGVGWVYEYALVDPTGQHDLSELRSIQDWF 163
Cdd:pfam00873 81 QSSYGLSSITLTFELGTDIDIARQDVQNRLQLATPLLPEGVQRpGISVIKTSLGPIMVLAVTSPDGSYTQTDLRDYADTN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 164 LKYELKTLPNVAEVATIGGMVKQYQVVLDPSKMATLGVTQNNVIEAIQKANQETGGSVLEMAETEYMVRASGYLKTLDDF 243
Cdd:pfam00873 161 IKPQLSRVPGVGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQSAEDF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 244 RQIPLRTNSfGVPVSLGDVATIQLGPEMRRGISELNGQgETVGGVVILRAGKNARETITAVKAKLAELQQSLPKGVQVVP 323
Cdd:pfam00873 241 EKIIVKNQD-GSPVRLRDVATVELGSELYRGFATFNGK-PAVGLGVQKLPGANAIETADAVRAKLAELKPTFPQGVEIVV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 324 VYDRSQLIDRAVENLSHKLIEEFIVVALVCGLFLWHLRSAMVAIVSLPLGILSAFLVMHYQGLNANIMSLGGIAIAIGAM 403
Cdd:pfam00873 319 VYDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVLAIGLV 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 404 VDAAIVMVENAHKHIETwQHEHPeqvLEAqvrwniITRSASEVGPTLFFCLLIITLSFIPIFTLQAQEGRLFSPLAFTKT 483
Cdd:pfam00873 399 VDDAIVVVENIERVLEE-NGLKP---LEA------AYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFAITIV 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 484 YAMAAAAGLSITLIPVLMGYWIRGKLPSEQR------NPLNRFLIKIYSPMLDKVLAHPKTILLGALLIFLISLFPLTRL 557
Cdd:pfam00873 469 LAILLSVLVALTLTPALCATLLKPRREPKHGgffrwfNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVGSVWLFVRI 548
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 558 GGEFLPNMDEGDLLYMPSALPGLSAAKASELLQQTDRMIKTVPEVATVFGKAGRAESAtDSAPLEMFETTIQFKPRSEWR 637
Cdd:pfam00873 549 PTEFLPEEDEGVFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTGFAFSG-DNNGPNSGDAFISLKPWKERP 627
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 638 SGM-TPDKLIKELDKAV-QVPGLTNIWVPPIRNRIDMLATGVKSPIGIKVSANDLQDIDRVAQQIEQVAKQVPGVSSALS 715
Cdd:pfam00873 628 GPEkSVQALIERLRKALkQIPGANVFLFQPIQLRGLGTISGFRSDLQVKIFGDDLDALDEARNQILAALAQLPGLSDVRS 707
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 716 ERLTGGRYVDVDINRMQAARYGLNIKDVQQIVSSAIGGENIGETVEGLARDPINVRYPREIRDSLEALRNLPILTESGQQ 795
Cdd:pfam00873 708 DGQEDQPQLQVNIDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQLYVRNPYGKM 787
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 796 IVLSSVANIQITDGPPMLKSENARPSGWIYVDVQGRDLASVVQDLKQAIDQKVKRSSAMSISYSGQFEFMERANARLKVV 875
Cdd:pfam00873 788 IPLSAFAKIEWGYGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQVKLPPGYGYTWTGQFEQEQLAGNSLPIL 867
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 876 IPITLMIIFLLLYLIFRQVQDAVLIMATLPFALIGGIWAMYLSDYHFSVAIAVGFIALAGVAAEFGVVMLFYLKQAIEHA 955
Cdd:pfam00873 868 IALALLVVFLVLAALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVEFANELREQE 947
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 956 QQSlssstaslteqqLNKAIHTGAVLRVRPKAMTVAVILAGLIPILLGTGTGSELMSRIALPMVGGMISAPLLSMFVIPA 1035
Cdd:pfam00873 948 GKS------------LEEAILEACRLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVVPV 1015
|
....*
gi 727723773 1036 AYQLL 1040
Cdd:pfam00873 1016 FYVLF 1020
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
27-1043 |
3.33e-116 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 382.83 E-value: 3.33e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 27 GTWAVKNTPVDALPDLSDVQVIIRTNFSGQAPQIVENQVTYPLTTTMLSVPGVKTVRGYSFFGDSFVYVIFDEHTDLYWA 106
Cdd:NF033617 22 GLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQSSLGYSTITLQFRLGTDLDVA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 107 RSRVLEYLNQIQGKMPANAKS-----SLGPDATGVGWVYEYALVDPTGQ-HDLSELRsiqdwfLKYELKTLPNVAEVATI 180
Cdd:NF033617 102 LSEVQAAINAAQSLLPSEAPDppvyrKANSADTPIMYIGLTSEEMPRGQlTDYAERV------LAPKLSQINGVGSVDVS 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 181 GGMVKQYQVVLDPSKMATLGVTQNNVIEAIQKANQETGGSVLEMAETEYMVRASGYLKTLDDFRQIPLRTNSFGVPVSLG 260
Cdd:NF033617 176 GGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQLKTAEDYEDLVIKYADNGAPVRLG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 261 DVATIQLGPEMRRGISELNGQGETVggVVILRA-GKNARETITAVKAKLAELQQSLPKGVQVVPVYDRSQLIDRAVENLS 339
Cdd:NF033617 256 DVATVELGAENVRNRAWANGVPAVV--LGINRQpGANPIEVADEIRALLPELQETLPKNIKVNVLYDRTRFIRASIDEVE 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 340 HKLIEEFIVVALVCGLFLWHLRSAMVAIVSLPLGILSAFLVMHYQGLNANIMSLGGIAIAIGAMVDAAIVMVENAHKHIE 419
Cdd:NF033617 334 STLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIGLVVDDAIVVVENIHRHIE 413
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 420 twQHEHPeqvLEAQVrwniitRSASEVGptlfFCLLIITLS----FIPIFTLQAQEGRLFSPLAFTKTYAMAAAAGLSIT 495
Cdd:NF033617 414 --EGESP---LEAAL------KGAREIG----FTVIAMTLTlvavYLPILFMGGLTGRLFREFAVTLAGAVIISGIVALT 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 496 LIPVlMGYWIRGKLPSEQR--NPLNRFLIKI---YSPMLDKVLAHPKTILLGALLIFLISLFPLTRLGGEFLPNMDEGDL 570
Cdd:NF033617 479 LTPM-MCSRLLKANEKPGRfaRAVDRFFDGLtarYGRGLKWVLKHRPLTLVVALATLALLPLLYVFIPKELAPSEDRGVI 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 571 LYMPSALPGLSAAKASELLQQTDRMIKTVPEVATVFGKAGRAESATDSAPLEMfettIQFKPRSEwRSgMTPDKLIKELD 650
Cdd:NF033617 558 FGMIQAPQSISLDYMSAKMRDVEKILSSDPEVQSLTSFNGVGGNPGDNTGFGI----INLKPWDE-RD-VSAQEIIDRLR 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 651 KAVQ-VPG--LTNIWVPPIRnridmLATGVKSPIGIKV-SANDLQDIDRVAQQIEQVAKQVPGVSSALSERLTGGRYVDV 726
Cdd:NF033617 632 PKLAkVPGmdLFLFPLQDLP-----GGAGSSLPQYQVTlTPSDYDSLFTWAEKLKEKLRKSPQFADVDSDLQDKGPELNV 706
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 727 DINRMQAARYGLNIKDVQQIVSSAIGGENIGETVEGLARDPINVRYPREIRDSLEALRNLPILTESGQQIVLSSVANIQI 806
Cdd:NF033617 707 DIDRDKAARLGISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDRRYRLNPEALNQIYVRSNDGKLVPLSTLAKIEE 786
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 807 TDGPPMLKSENARPSGWIYVDV-QGRDLASVVQDLKQAIDQKVKRSsaMSISYSGQFEFMERANARLKVVIPITLMIIFL 885
Cdd:NF033617 787 RAAPLSLNHFNQFNSATLSFNLaPGVSLGEAIEALDQAAKELLPSG--ISGSFQGAARAFQEEGSSLLFLFLLALAAIYL 864
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 886 LLYLIFRQVQDAVLIMATLPFALIGGIWAMYLSDYHFSVAIAVGFIALAGVAAEFGVVMLFYLKQAIEHAQQslssstas 965
Cdd:NF033617 865 VLAIQYESFVDPLTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLVKKNGILMVEFANELQRHQGL-------- 936
|
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727723773 966 lteqQLNKAIHTGAVLRVRPKAMTVAVILAGLIPILLGTGTGSELMSRIALPMVGGMISAPLLSMFVIPAAYqLLIKR 1043
Cdd:NF033617 937 ----SRREAIYQAAALRLRPILMTTLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGTLFTLFVLPVVY-LLLAR 1009
|
|
| PRK09579 |
PRK09579 |
multidrug efflux RND transporter permease subunit; |
27-1043 |
1.20e-66 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169983 [Multi-domain] Cd Length: 1017 Bit Score: 243.59 E-value: 1.20e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 27 GTWAVKNTPVDALPDLSDVQVIIRTNFSGQAPQIVENQVTYPLTTTMLSVPGVKTVRGYSF--FGDSFVYVIFDEHTDLY 104
Cdd:PRK09579 25 GFQAWSKLQIRQYPQMENALITVTTAYPGANAETIQGYITQPLQQSLASAEGIDYMTSVSRqnFSIISIYARIGADSDRL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 105 WarSRVLEYLNQIQGKMPANAK----SSLGPDATGVGWV--YEYALVDPTGQHDLSelRSIQDwflkyELKTLPNVAEVA 178
Cdd:PRK09579 105 F--TELLAKANEVKNQLPQDAEdpvlSKEAADASALMYIsfYSEEMSNPQITDYLS--RVIQP-----KLATLPGMAEAE 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 179 TIGGMVKQYQVVLDPSKMATLGVTQNNVIEAIQKAN-QETGGSVlemaETEYMV---RASGYLKTLDDFRQIPLRTNSfG 254
Cdd:PRK09579 176 ILGNQVFAMRLWLDPVKLAGFGLSAGDVTQAVRRYNfLSAAGEV----KGEYVVtsiNASTELKSAEAFAAIPVKTSG-D 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 255 VPVSLGDVATIQLGPEMRRGISELNGQGETVGGVVILRAGkNARETITAVKAKLAELQQSLPKGVQVVPVYDRSQLIDRA 334
Cdd:PRK09579 251 SRVLLGDVARVEMGAENYDSISSFDGIPSVYIGIKATPSA-NPLDVIKEVRAIMPELESQLPPNLKVSIAYDATLFIQAS 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 335 VENLSHKLIEEFIVVALVCGLFLWHLRSAMVAIVSLPLGILSAFLVMHYQGLNANIMSLGGIAIAIGAMVDAAIVMVENA 414
Cdd:PRK09579 330 IDEVVKTLGEAVLIVIVVVFLFLGALRSVLIPVVTIPLSMIGVLFFMQMMGYSINLLTLLAMVLAIGLVVDDAIVVVENI 409
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 415 HKHIEtwqhehpeqvlEAQVRWNIITRSASEVGPTLFFCLLIITLSFIPIFTLQAQEGRLFSPLAFTKTYAMAAAAGLSI 494
Cdd:PRK09579 410 HRHIE-----------EGKSPFDAALEGAREIAMPVVSMTITLAAVYAPIGFLTGLTGALFKEFALTLAGAVIISGIVAL 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 495 TLIPVLMGYWIR-GKLPSEQRNPLNRF---LIKIYSPMLDKVL-AHPKTILLGALLIFLISLFpLTRLGGEFLPNMDEGD 569
Cdd:PRK09579 479 TLSPMMCALLLRhEENPSGLAHRLDRLferLKQRYQRALHGTLnTRPVVLVFAVIVLALIPVL-LKFTQSELAPEEDQGI 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 570 LLYMPSALPGLSAAKASELLQQTDRMIKTVPEVATVFGKAGraesatdsapLEMFETTIQ---FKPRSEW-RSGMTPDKL 645
Cdd:PRK09579 558 IFMMSSSPQPANLDYLNAYTDEFTPIFKSFPEYYSSFQING----------FNGVQSGIGgflLKPWNEReRTQMELLPL 627
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 646 IKEldKAVQVPGLTNIWVppirNRIDMLATGVKSPIGIKV-SANDLQDIDRVAQQIEQVAkQVPGVSSALSERLTGGR-Y 723
Cdd:PRK09579 628 VQA--KLEEIPGLQIFGF----NLPSLPGTGEGLPFQFVInTANDYESLLQVAQRVKQRA-QESGKFAFLDIDLAFDKpE 700
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 724 VDVDINRMQAARYGLNIKDVQQIVSSAIGGENIGE-TVEGLARDPInVRYPREIRDSLEALRNLPILTESGQQIVLSSVA 802
Cdd:PRK09579 701 VVVDIDRAKAAQMGVSMQDLGGTLATLLGEGEINRfTIDGRSYKVI-AQVERPYRDNPGWLNNYYVKNEQGQLLPLSTLI 779
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 803 NIQITDGPPMLKSENARPSGWIyvdvQGRDLASvvqdLKQAID--QKVKRSSA---MSISYSG-QFEFMERANArLKVVI 876
Cdd:PRK09579 780 TLSDRARPRQLNQFQQLNSAII----SGFPIVS----MGEAIEtvQQIAREEApegFAFDYAGaSRQYVQEGSA-LWVTF 850
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 877 PITLMIIFLLLYLIFRQVQDAVLIMATLPFALIGGIWAMYLSDYHFSVAIAVGFIALAGVAAEFGVVMLFYLKQAIEhaq 956
Cdd:PRK09579 851 GLALAIIFLVLAAQFESFRDPLVILVTVPLSICGALIPLFLGVSSMNIYTQVGLVTLIGLISKHGILIVEFANQLRH--- 927
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 957 qslssstasltEQQLN--KAIHTGAVLRVRPKAMTVAVILAGLIPILLGTGTGSELMSRIALPMVGGMISAPLLSMFVIP 1034
Cdd:PRK09579 928 -----------EQGLSrrEAIEEAAAIRLRPVLMTTAAMVFGMVPLILATGAGAVSRFDIGLVIATGMSIGTLFTLFVLP 996
|
....*....
gi 727723773 1035 AAYQLLIKR 1043
Cdd:PRK09579 997 CIYTLLAKP 1005
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
535-931 |
4.93e-08 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 57.33 E-value: 4.93e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 535 HPKTILLGALLIFLISLFPLTRLGGEFLPNMDEgDLLYMPSALPGLSAakasELLQQTdrmIKTVPEVAtvFGKAGRAES 614
Cdd:NF033617 7 RPVATLLLSLLILLLGLLAFRKLPVREYPEVDF-PTITVSTSYPGASP----ELMQSS---ITQPLEQQ--LAQIEGIDE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 615 ATDSAPLEMFETTIQFkprsewRSGMTPDKLIKELDKAVQV------PGLTNiwvPPIRNRIDMLATGVkspIGIKVSAN 688
Cdd:NF033617 77 MTSQSSLGYSTITLQF------RLGTDLDVALSEVQAAINAaqsllpSEAPD---PPVYRKANSADTPI---MYIGLTSE 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 689 DL---QDIDRVAQQIEQVAKQVPGVSSAlseRLTGGRY--VDVDINRMQAARYGLNIKDVQQIVSSA----IGGENIGET 759
Cdd:NF033617 145 EMprgQLTDYAERVLAPKLSQINGVGSV---DVSGGQRpaMRVWLDPEKMAARGLTADDVRSALNSNnvnsPKGAVRGDS 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 760 VEglardpINVRYPREIRdSLEALRNLPI-LTESGQQIVLSSVANiqITDGPpmlksENARPSGW------IYVDVQGRD 832
Cdd:NF033617 222 VV------STVRANDQLK-TAEDYEDLVIkYADNGAPVRLGDVAT--VELGA-----ENVRNRAWangvpaVVLGINRQP 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 833 LA---SVVQDLKQAIDQKVK---RSSAMSISYSgQFEFMERANARLKVVIPITLMIIFLLLYLIFRQVQdAVLIMA-TLP 905
Cdd:NF033617 288 GAnpiEVADEIRALLPELQEtlpKNIKVNVLYD-RTRFIRASIDEVESTLLEAVALVILVVFLFLRNLR-ATLIPAvTVP 365
|
410 420 430
....*....|....*....|....*....|....
gi 727723773 906 FALIGGIWAMYLSDyhFSV--------AIAVGFI 931
Cdd:NF033617 366 LSLIGTFAVMYLFG--FSInlltlmalVLAIGLV 397
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| CusA |
COG3696 |
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism]; |
1-1047 |
0e+00 |
|
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 1494.91 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 1 MIARIIRFSIANRVFVLLAALILAAWGTWAVKNTPVDALPDLSDVQVIIRTNFSGQAPQIVENQVTYPLTTTMLSVPGVK 80
Cdd:COG3696 1 MLNRIIRFSLRNRLLVLLLTLLLAAAGIYSLRRLPIDAFPDITNVQVQVITEAPGLSPEEVEQQVTYPIETALNGLPGVK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 81 TVRGYSFFGDSFVYVIFDEHTDLYWARSRVLEYLNQIQGKMPANAKSSLGPDATGVGWVYEYALVDPTGQHDLSELRSIQ 160
Cdd:COG3696 81 EVRSISRFGLSVVTVIFEDGTDIYWARQLVLERLQQVREQLPAGVTPELGPISTGLGEIYQYTLESDPGKYSLMELRTLQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 161 DWFLKYELKTLPNVAEVATIGGMVKQYQVVLDPSKMATLGVTQNNVIEAIQKANQETGGSVLEMAETEYMVRASGYLKTL 240
Cdd:COG3696 161 DWVIRPQLRSVPGVAEVNSFGGFVKQYQVLVDPAKLRAYGLTLDDVIEALERNNANVGGGYIERGGQEYLVRGIGLIRSL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 241 DDFRQIPLRTNSfGVPVSLGDVATIQLGPEMRRGISELNGQGETVGGVVILRAGKNARETITAVKAKLAELQQSLPKGVQ 320
Cdd:COG3696 241 EDIENIVVKTRN-GTPVLLRDVAEVRIGPAPRRGAATLNGEGEVVGGIVLMLKGENALEVIEAVKAKLAELKPSLPEGVK 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 321 VVPVYDRSQLIDRAVENLSHKLIEEFIVVALVCGLFLWHLRSAMVAIVSLPLGILSAFLVMHYQGLNANIMSLGGIAIAI 400
Cdd:COG3696 320 IVPFYDRSDLIDRAIHTVTKNLLEGALLVILVLFLFLGNLRAALIVALAIPLSLLFAFIVMRLFGISANLMSLGGLAIDF 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 401 GAMVDAAIVMVENAHKHIETWQHEHpeqvlEAQVRWNIITRSASEVGPTLFFCLLIITLSFIPIFTLQAQEGRLFSPLAF 480
Cdd:COG3696 400 GIIVDGAVVMVENILRRLEENRAAG-----TPRERLEVVLEAAREVRRPIFFATLIIILVFLPIFTLEGVEGKLFRPMAL 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 481 TKTYAMAAAAGLSITLIPVLMGYWIRGKLPsEQRNPLNRFLIKIYSPMLDKVLAHPKTILLGALLIFLISLFPLTRLGGE 560
Cdd:COG3696 475 TVIFALLGALLLSLTLVPVLASLLLRGKVP-EKENPLVRWLKRLYRPLLRWALRHPKLVLAVALVLLVLALALFPRLGSE 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 561 FLPNMDEGDLLYMPSALPGLSAAKASELLQQTDRMIKTVPEVATVFGKAGRAESATDSAPLEMFETTIQFKPRSEWRSGM 640
Cdd:COG3696 554 FLPELDEGDLLVMATLPPGISLEESVELGQQVERILKSFPEVESVVSRTGRAEDATDPMGVNMSETFVILKPRSEWRSGR 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 641 TPDKLIKELDKAV-QVPGLTNIWVPPIRNRIDMLATGVKSPIGIKVSANDLQDIDRVAQQIEQVAKQVPGVSSALSERLT 719
Cdd:COG3696 634 TKEELIAEMREALeQIPGVNFNFSQPIQMRVDELLSGVRADVAVKIFGDDLDVLRRLAEQIEAVLKTVPGAADVQVERVT 713
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 720 GGRYVDVDINRMQAARYGLNIKDVQQIVSSAIGGENIGETVEGLARDPINVRYPREIRDSLEALRNLPILTESGQQIVLS 799
Cdd:COG3696 714 GLPQLDIRIDRDAAARYGLNVADVQDVVETAIGGKAVGQVYEGERRFDIVVRLPEELRDDPEAIRNLPIPTPSGAQVPLS 793
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 800 SVANIQITDGPPMLKSENARPSGWIYVDVQGRDLASVVQDLKQAIDQKVKRSSAMSISYSGQFEFMERANARLKVVIPIT 879
Cdd:COG3696 794 QVADIEVVEGPNQISRENGRRRIVVQANVRGRDLGSFVAEAQAKVAEQVKLPPGYYIEWGGQFENLQRATARLAIVVPLA 873
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 880 LMIIFLLLYLIFRQVQDAVLIMATLPFALIGGIWAMYLSDYHFSVAIAVGFIALAGVAAEFGVVMLFYLKQAIEHAqqsl 959
Cdd:COG3696 874 LLLIFLLLYLAFGSVRDALLILLNVPFALIGGVLALWLRGMPLSVSAGVGFIALFGVAVLNGVVLVSYINQLRAEG---- 949
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 960 ssstaslteQQLNKAIHTGAVLRVRPKAMTVAVILAGLIPILLGTGTGSELMSRIALPMVGGMISAPLLSMFVIPAAYQL 1039
Cdd:COG3696 950 ---------LDLREAIIEGALERLRPVLMTALVAALGLLPMALSTGPGSEVQRPLATVVIGGLITSTLLTLLVLPALYLL 1020
|
....*...
gi 727723773 1040 LIKRKLSK 1047
Cdd:COG3696 1021 FGRRRLRR 1028
|
|
| 2A0601 |
TIGR00914 |
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ... |
1-1044 |
0e+00 |
|
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 129992 [Multi-domain] Cd Length: 1051 Bit Score: 1314.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 1 MIARIIRFSIANRVFVLLAALILAAWGTWAVKNTPVDALPDLSDVQVIIRTNFSGQAPQIVENQVTYPLTTTMLSVPGVK 80
Cdd:TIGR00914 1 MIERIISFSVAQRWLVLLATLVMAILGIWSYNRLPIDAVPDITNVQVQINTSAPGYSPLEVEQRVTYPIETAMAGLPGLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 81 TVRGYSFFGDSFVYVIFDEHTDLYWARSRVLEYLNQIQGKMPANAKSSLGPDATGVGWVYEYALVDPTG-------QHDL 153
Cdd:TIGR00914 81 TTRSLSRYGLSQVTVIFKDGTDLYFARQLVNERLQQARDNLPEGVSPEMGPISTGLGEIFLYTVEAEEGarkkdggAYTL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 154 SELRSIQDWFLKYELKTLPNVAEVATIGGMVKQYQVVLDPSKMATLGVTQNNVIEAIQKANQETGGSVLEMAETEYMVRA 233
Cdd:TIGR00914 161 TDLRTIQDWIIRPQLRTVPGVAEVNSIGGYVKQFLVAPDPEKLAAYGLSLADVVNALERNNQNVGAGYIERRGEQYLVRA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 234 SGYLKTLDDFRQIPLRTnSFGVPVSLGDVATIQLGPEMRRGISELNGQgETVGGVVILRAGKNARETITAVKAKLAELQQ 313
Cdd:TIGR00914 241 PGQVQSMDDIRNIVIAT-GEGVPIRIRDVARVQIGKELRTGAATENGK-EVVLGTVFMLIGENSRTVAQAVGDKLETINK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 314 SLPKGVQVVPVYDRSQLIDRAVENLSHKLIEEFIVVALVCGLFLWHLRSAMVAIVSLPLGILSAFLVMHYQGLNANIMSL 393
Cdd:TIGR00914 319 TLPEGVEIVTTYDRSQLVDAAIATVKKNLLEGALLVIVILFLFLGNIRAALIAATVIPLSLLITFIGMVFQGISANLMSL 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 394 GgiAIAIGAMVDAAIVMVENAHKHIETWQHEHPEQvLEAQVRWNIITRSASEVGPTLFFCLLIITLSFIPIFTLQAQEGR 473
Cdd:TIGR00914 399 G--ALDFGLIVDGAVVIVENAHRRLAEAQHHHGRQ-LTLKERLHEVFAASREVRRPLIFGQLIITLVFLPIFTLTGVEGK 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 474 LFSPLAFTKTYAMAAAAGLSITLIPVLMGYWIRGKLPsEQRNPLNRFLIKIYSPMLDKVLAHPKTILLGALLIFLISLFP 553
Cdd:TIGR00914 476 MFHPMAFTVVLALAGAMILSLTFVPAAVALFIRGKVA-EKENRLMRVLKRRYEPLLERVLAWPAVVLGAAAVSIVLVVWI 554
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 554 LTRLGGEFLPNMDEGDLLYMPSALPGLSAAKASELLQQTDRMIKTVPEVATVFGKAGRAESATDSAPLEMFETTIQFKPR 633
Cdd:TIGR00914 555 ASRVGGEFIPSLNEGDLAYQALRIPGTSLAQSVAMQQTLEKLIKSFPEVARVFAKTGTAEIATDPMPPNASDTYIILKPE 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 634 SEWRSG--MTPDKLIKELDKAVQVPGLTNIWVPPIRNRIDMLATGVKSPIGIKVSANDLQDIDRVAQQIEQVAKQVPGVS 711
Cdd:TIGR00914 635 SQWPEGkkTKEDLIEEIQEATVRIPGNNYEFTQPIQMRFNELISGVRSDVAVKVFGDDLDDLDATAEKISAVLKGVPGAA 714
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 712 SALSERLTGGRYVDVDINRMQAARYGLNIKDVQQIVSSAIGGENIGETVEGLARDPINVRYPREIRDSLEALRNLPILTE 791
Cdd:TIGR00914 715 DVKVEQTTGLPYLTVEIDREKAARYGLTVGDVQDTVATAVGGRMSGETFEGDRRFDIVIRLPESLRESPQALRQLPIPLP 794
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 792 SG-----QQIVLSSVANIQITDGPPMLKSENARPSGWIYVDVQGRDLASVVQDLKQAIDQKVKRSSAMSISYSGQFEFME 866
Cdd:TIGR00914 795 LSedarkQFIPLSDVADLRVSPGPNQISRENGKRRVVVSANVRGRDLGSFVDDAKKAIAEQVKLPPGYWITWGGQFEQLQ 874
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 867 RANARLKVVIPITLMIIFLLLYLIFRQVQDAVLIMATLPFALIGGIWAMYLSDYHFSVAIAVGFIALAGVAAEFGVVMLF 946
Cdd:TIGR00914 875 SATKRLQIVVPVTLLLIFVLLYAAFGNVKDALLVFTGIPFALTGGVFALWLRGIPLSISAAVGFIALSGVAVLNGLVMIS 954
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 947 YLKQAIEHAQQslssstaslteqqLNKAIHTGAVLRVRPKAMTVAVILAGLIPILLGTGTGSELMSRIALPMVGGMISAP 1026
Cdd:TIGR00914 955 FIRKLLEEGPS-------------LDEAVYEGALTRVRPVLMTALVASLGFVPMAIATGTGAEVQRPLATVVIGGIITAT 1021
|
1050
....*....|....*...
gi 727723773 1027 LLSMFVIPAAYQLLIKRK 1044
Cdd:TIGR00914 1022 LLTLFVLPALYRLVHRRR 1039
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
5-1040 |
0e+00 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 720.23 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 5 IIRFSIANRVFVLLAALILAAWGTWAVKNTPVDALPDLSDVQVIIRTNFSGQAPQIVENQVTYPLTTTMLSVPGVKTVRG 84
Cdd:pfam00873 1 MSKFFIRRPIFTLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 85 YSFFGDSFVYVIFDEHTDLYWARSRVLEYLNQIQGKMPANAKS-SLGPDATGVGWVYEYALVDPTGQHDLSELRSIQDWF 163
Cdd:pfam00873 81 QSSYGLSSITLTFELGTDIDIARQDVQNRLQLATPLLPEGVQRpGISVIKTSLGPIMVLAVTSPDGSYTQTDLRDYADTN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 164 LKYELKTLPNVAEVATIGGMVKQYQVVLDPSKMATLGVTQNNVIEAIQKANQETGGSVLEMAETEYMVRASGYLKTLDDF 243
Cdd:pfam00873 161 IKPQLSRVPGVGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQSAEDF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 244 RQIPLRTNSfGVPVSLGDVATIQLGPEMRRGISELNGQgETVGGVVILRAGKNARETITAVKAKLAELQQSLPKGVQVVP 323
Cdd:pfam00873 241 EKIIVKNQD-GSPVRLRDVATVELGSELYRGFATFNGK-PAVGLGVQKLPGANAIETADAVRAKLAELKPTFPQGVEIVV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 324 VYDRSQLIDRAVENLSHKLIEEFIVVALVCGLFLWHLRSAMVAIVSLPLGILSAFLVMHYQGLNANIMSLGGIAIAIGAM 403
Cdd:pfam00873 319 VYDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVLAIGLV 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 404 VDAAIVMVENAHKHIETwQHEHPeqvLEAqvrwniITRSASEVGPTLFFCLLIITLSFIPIFTLQAQEGRLFSPLAFTKT 483
Cdd:pfam00873 399 VDDAIVVVENIERVLEE-NGLKP---LEA------AYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFAITIV 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 484 YAMAAAAGLSITLIPVLMGYWIRGKLPSEQR------NPLNRFLIKIYSPMLDKVLAHPKTILLGALLIFLISLFPLTRL 557
Cdd:pfam00873 469 LAILLSVLVALTLTPALCATLLKPRREPKHGgffrwfNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVGSVWLFVRI 548
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 558 GGEFLPNMDEGDLLYMPSALPGLSAAKASELLQQTDRMIKTVPEVATVFGKAGRAESAtDSAPLEMFETTIQFKPRSEWR 637
Cdd:pfam00873 549 PTEFLPEEDEGVFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTGFAFSG-DNNGPNSGDAFISLKPWKERP 627
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 638 SGM-TPDKLIKELDKAV-QVPGLTNIWVPPIRNRIDMLATGVKSPIGIKVSANDLQDIDRVAQQIEQVAKQVPGVSSALS 715
Cdd:pfam00873 628 GPEkSVQALIERLRKALkQIPGANVFLFQPIQLRGLGTISGFRSDLQVKIFGDDLDALDEARNQILAALAQLPGLSDVRS 707
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 716 ERLTGGRYVDVDINRMQAARYGLNIKDVQQIVSSAIGGENIGETVEGLARDPINVRYPREIRDSLEALRNLPILTESGQQ 795
Cdd:pfam00873 708 DGQEDQPQLQVNIDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQLYVRNPYGKM 787
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 796 IVLSSVANIQITDGPPMLKSENARPSGWIYVDVQGRDLASVVQDLKQAIDQKVKRSSAMSISYSGQFEFMERANARLKVV 875
Cdd:pfam00873 788 IPLSAFAKIEWGYGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQVKLPPGYGYTWTGQFEQEQLAGNSLPIL 867
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 876 IPITLMIIFLLLYLIFRQVQDAVLIMATLPFALIGGIWAMYLSDYHFSVAIAVGFIALAGVAAEFGVVMLFYLKQAIEHA 955
Cdd:pfam00873 868 IALALLVVFLVLAALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVEFANELREQE 947
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 956 QQSlssstaslteqqLNKAIHTGAVLRVRPKAMTVAVILAGLIPILLGTGTGSELMSRIALPMVGGMISAPLLSMFVIPA 1035
Cdd:pfam00873 948 GKS------------LEEAILEACRLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVVPV 1015
|
....*
gi 727723773 1036 AYQLL 1040
Cdd:pfam00873 1016 FYVLF 1020
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
4-1044 |
0e+00 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 630.98 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 4 RIIRFSIANRVFVLLAALILAAWGTWAVKNTPVDALPDLSDVQVIIRTNFSGQAPQIVENQVTYPLTTTMLSVPGVKTVR 83
Cdd:COG0841 2 NLSRFFIRRPVAAIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYIT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 84 GYSFFGDSFVYVIFDEHTDLYWARSRVLEYLNQIQGKMPANAK----SSLGPDATGVGWVyeyALVDPTgqHDLSELRSI 159
Cdd:COG0841 82 STSSEGSSSITVEFELGTDIDEALVDVQNAVDRARSDLPEDVEppgvTKVNPSDFPVMVL---ALSSDD--LDELELSDY 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 160 QDWFLKYELKTLPNVAEVATIGGMVKQYQVVLDPSKMATLGVTQNNVIEAIQKANQETGGSVLEMAETEYMVRASGYLKT 239
Cdd:COG0841 157 AERNIKDRLERVPGVGQVQIFGGREREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGGGDREYTVRTNGRLKT 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 240 LDDFRQIPLRTNSfGVPVSLGDVATIQLGPEMRRGISELNGQgETVGGVVILRAGKNARETITAVKAKLAELQQSLPKGV 319
Cdd:COG0841 237 PEEFENIVIRTND-GSVVRLGDVARVEDGAEDYRSIARLNGK-PAVGLAIQKQPGANALEVADAVRAKLEELQASLPEGV 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 320 QVVPVYDRSQLIDRAVENLSHKLIEEFIVVALVCGLFLWHLRSAMVAIVSLPLGILSAFLVMHYQGLNANIMSLGGIAIA 399
Cdd:COG0841 315 ELTIVYDQSEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFALVLA 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 400 IGAMVDAAIVMVENAHKHIEtwQHEHPeqvLEAqvrwniITRSASEVGPTLFFclliITLS----FIPIFTLQAQEGRLF 475
Cdd:COG0841 395 IGIVVDDAIVVVENIERHME--EGLSP---LEA------AIKGAREVAGAVIA----STLTlvavFLPLAFMGGITGQLF 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 476 SPLAFTKTYAMAAAAGLSITLIPVLMGYWIRGKLPSEQRNPLNRF------LIKIYSPMLDKVLAHPKTILLGALLIFLI 549
Cdd:COG0841 460 RQFALTVAIALLISLFVALTLTPALCARLLKPHPKGKKGRFFRAFnrgfdrLTRGYGRLLRWALRHRKLTLLVALALLAL 539
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 550 SLFPLTRLGGEFLPNMDEGDLLYMPSALPGLSAAKASELLQQTDRMIKTVPEVATVFGKAGRAESATDSAPLEMFettIQ 629
Cdd:COG0841 540 SVLLFGRLPTEFFPEEDQGQIIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVGFSGGGSGSNSGTIF---VT 616
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 630 FKPRSEwRSgMTPDKLIKELDKAV-QVPGLTN-IWVPPIRNRidmlatGVKSPIGIKVSANDLQDIDRVAQQIEQVAKQV 707
Cdd:COG0841 617 LKPWDE-RD-RSADEIIARLREKLaKIPGARVfVFQPPAGGL------GSGAPIEVQLQGDDLEELAAAAEKLLAALRQI 688
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 708 PGVSSALSERLTGGRYVDVDINRMQAARYGLNIKDVQQIVSSAIGGENIGETVEGLARDPINVRYPREIRDSLEALRNLP 787
Cdd:COG0841 689 PGLVDVRSDLQLGKPELQLDIDREKAAALGVTVADVASTLRAALGGRYVNDFNRGGREYDVRVQAPEEDRNSPEDLENLY 768
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 788 ILTESGQQIVLSSVANIQITDGPPMLKSENARPSGWIYVDV-QGRDLASVVQDLKQAIDQKVKRSSaMSISYSGQFEFME 866
Cdd:COG0841 769 VRTPDGEMVPLSSVATIEEGTGPSSINRYNGQRSVTVSANLaPGVSLGEALAAIEELAAELKLPPG-VSIEFTGQAEEEQ 847
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 867 RANARLKVVIPITLMIIFLLLYLIFRQVQDAVLIMATLPFALIGGIWAMYLSDYHFSVAIAVGFIALAGVAAEFGVVMLF 946
Cdd:COG0841 848 ESFSSLGLAFLLALLLVYLVLAAQFESFIQPLIILLTVPLALIGALLGLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVD 927
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 947 YLKQAIEHAQQslssstaslteqqLNKAIHTGAVLRVRPKAMTVAVILAGLIPILLGTGTGSELMSRIALPMVGGMISAP 1026
Cdd:COG0841 928 FANQLREEGMS-------------LREAILEAARLRLRPILMTSLATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFST 994
|
1050
....*....|....*...
gi 727723773 1027 LLSMFVIPAAYQLLIKRK 1044
Cdd:COG0841 995 LLTLFVVPVLYVLLDRLR 1012
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
27-1043 |
3.33e-116 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 382.83 E-value: 3.33e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 27 GTWAVKNTPVDALPDLSDVQVIIRTNFSGQAPQIVENQVTYPLTTTMLSVPGVKTVRGYSFFGDSFVYVIFDEHTDLYWA 106
Cdd:NF033617 22 GLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQSSLGYSTITLQFRLGTDLDVA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 107 RSRVLEYLNQIQGKMPANAKS-----SLGPDATGVGWVYEYALVDPTGQ-HDLSELRsiqdwfLKYELKTLPNVAEVATI 180
Cdd:NF033617 102 LSEVQAAINAAQSLLPSEAPDppvyrKANSADTPIMYIGLTSEEMPRGQlTDYAERV------LAPKLSQINGVGSVDVS 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 181 GGMVKQYQVVLDPSKMATLGVTQNNVIEAIQKANQETGGSVLEMAETEYMVRASGYLKTLDDFRQIPLRTNSFGVPVSLG 260
Cdd:NF033617 176 GGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQLKTAEDYEDLVIKYADNGAPVRLG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 261 DVATIQLGPEMRRGISELNGQGETVggVVILRA-GKNARETITAVKAKLAELQQSLPKGVQVVPVYDRSQLIDRAVENLS 339
Cdd:NF033617 256 DVATVELGAENVRNRAWANGVPAVV--LGINRQpGANPIEVADEIRALLPELQETLPKNIKVNVLYDRTRFIRASIDEVE 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 340 HKLIEEFIVVALVCGLFLWHLRSAMVAIVSLPLGILSAFLVMHYQGLNANIMSLGGIAIAIGAMVDAAIVMVENAHKHIE 419
Cdd:NF033617 334 STLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIGLVVDDAIVVVENIHRHIE 413
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 420 twQHEHPeqvLEAQVrwniitRSASEVGptlfFCLLIITLS----FIPIFTLQAQEGRLFSPLAFTKTYAMAAAAGLSIT 495
Cdd:NF033617 414 --EGESP---LEAAL------KGAREIG----FTVIAMTLTlvavYLPILFMGGLTGRLFREFAVTLAGAVIISGIVALT 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 496 LIPVlMGYWIRGKLPSEQR--NPLNRFLIKI---YSPMLDKVLAHPKTILLGALLIFLISLFPLTRLGGEFLPNMDEGDL 570
Cdd:NF033617 479 LTPM-MCSRLLKANEKPGRfaRAVDRFFDGLtarYGRGLKWVLKHRPLTLVVALATLALLPLLYVFIPKELAPSEDRGVI 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 571 LYMPSALPGLSAAKASELLQQTDRMIKTVPEVATVFGKAGRAESATDSAPLEMfettIQFKPRSEwRSgMTPDKLIKELD 650
Cdd:NF033617 558 FGMIQAPQSISLDYMSAKMRDVEKILSSDPEVQSLTSFNGVGGNPGDNTGFGI----INLKPWDE-RD-VSAQEIIDRLR 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 651 KAVQ-VPG--LTNIWVPPIRnridmLATGVKSPIGIKV-SANDLQDIDRVAQQIEQVAKQVPGVSSALSERLTGGRYVDV 726
Cdd:NF033617 632 PKLAkVPGmdLFLFPLQDLP-----GGAGSSLPQYQVTlTPSDYDSLFTWAEKLKEKLRKSPQFADVDSDLQDKGPELNV 706
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 727 DINRMQAARYGLNIKDVQQIVSSAIGGENIGETVEGLARDPINVRYPREIRDSLEALRNLPILTESGQQIVLSSVANIQI 806
Cdd:NF033617 707 DIDRDKAARLGISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDRRYRLNPEALNQIYVRSNDGKLVPLSTLAKIEE 786
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 807 TDGPPMLKSENARPSGWIYVDV-QGRDLASVVQDLKQAIDQKVKRSsaMSISYSGQFEFMERANARLKVVIPITLMIIFL 885
Cdd:NF033617 787 RAAPLSLNHFNQFNSATLSFNLaPGVSLGEAIEALDQAAKELLPSG--ISGSFQGAARAFQEEGSSLLFLFLLALAAIYL 864
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 886 LLYLIFRQVQDAVLIMATLPFALIGGIWAMYLSDYHFSVAIAVGFIALAGVAAEFGVVMLFYLKQAIEHAQQslssstas 965
Cdd:NF033617 865 VLAIQYESFVDPLTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLVKKNGILMVEFANELQRHQGL-------- 936
|
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727723773 966 lteqQLNKAIHTGAVLRVRPKAMTVAVILAGLIPILLGTGTGSELMSRIALPMVGGMISAPLLSMFVIPAAYqLLIKR 1043
Cdd:NF033617 937 ----SRREAIYQAAALRLRPILMTTLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGTLFTLFVLPVVY-LLLAR 1009
|
|
| 2A0602 |
TIGR00915 |
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ... |
7-1046 |
7.44e-73 |
|
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]
Pssm-ID: 273335 [Multi-domain] Cd Length: 1044 Bit Score: 261.97 E-value: 7.44e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 7 RFSIANRVFVLLAALILAAWGTWAVKNTPVDALPDLSDVQVIIRTNFSGQAPQIVENQVTYPLTTTMLSVPGVKTVRGYS 86
Cdd:TIGR00915 3 KFFIDRPIFAWVIAIIIMLAGTLSILSLPVSQYPSIAPPAITVSASYPGASAQTVQDTVTQVIEQNMNGIDGLRYMSSSS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 87 -FFGDSFVYVIFDEHTDLYWARSRVLEYLNQIQGKMPANA-KSSLGPDATGVGWVYEYALVDPTGQHDLSELRSIQDWFL 164
Cdd:TIGR00915 83 dSDGSMTITLTFEQGTDPDIAQVQVQNKLQLATPLLPQEVqRQGVRVEKASSNFLMVIGLVSDDGSMTKEDLSDYAASNM 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 165 KYELKTLPNVAEVATIGgmvKQY--QVVLDPSKMATLGVTQNNVIEAIQKAN-QETGGSV-----LEMAETEYMVRASGY 236
Cdd:TIGR00915 163 VDPLSRLEGVGDVQLFG---SQYamRIWLDPAKLNSYQLTPADVISAISAQNaQISAGQLgglpaVPGQQLNATIIAQTR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 237 LKTLDDFRQIPLRTNSFGVPVSLGDVATIQLGPEMRRGISELNGQgETVGGVVILRAGKNARETITAVKAKLAELQQSLP 316
Cdd:TIGR00915 240 LQTPEQFENILLKVNTDGSQVRLKDVARVELGGENYSISARFNGK-PASGLAIKLATGANALDTAKAVKAELAVLEPFFP 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 317 KGVQVVPVYDRSQLIDRAVENLSHKLIEEFIVVALVCGLFLWHLRSAMVAIVSLPLGILSAFLVMHYQGLNANIMSLGGI 396
Cdd:TIGR00915 319 QGMKYVYPYDTTPFVEASIEEVVHTLIEAIVLVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFAM 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 397 AIAIGAMVDAAIVMVENahkhIETWQHEHPEQVLEA-QVRWNIItrSASEVGPTlffclLIITLSFIPIFTLQAQEGRLF 475
Cdd:TIGR00915 399 VLAIGLLVDDAIVVVEN----VERVMAEEGLPPKEAtRKSMGQI--QGALVGIA-----MVLSAVFVPMAFFGGSTGAIY 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 476 SPLAFTKTYAMAAAAGLSITLIPVL---MGYWIRGKLPSEQR----NPLNRFLIKI---YSPMLDKVLAHPKTILLGALL 545
Cdd:TIGR00915 468 RQFSITIVSAMALSVLVALILTPALcatMLKPIEKGEHHEKKggffGWFNRMFDSSthgYENGVGKILRRRGRYLLVYVL 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 546 IFLISLFPLTRLGGEFLPNMDEGDLLYMPSALPGLSAAKASELLQQTDR--MIKTVPEVATV-----FGKAGRAESATds 618
Cdd:TIGR00915 548 LVGGMVFLFVRLPTSFLPDEDQGVFMTIVQLPAGATAERTQAVLAQVTKylLAKEKANVESVftvngFSFAGRGQNMG-- 625
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 619 aplEMFettIQFKPRSEwRSGMTPDklikeldkavqvpgltniwVPPIRNRIDMLATGVKSPIGIKV-----------SA 687
Cdd:TIGR00915 626 ---MAF---IRLKDWEE-RTGKENS-------------------VFAIAGRATGHFMQIKDAMVIAFvppailelgnaTG 679
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 688 NDLQDIDRVAQ----------QIEQVAKQVPGVSSALSERLTGGRYVDVDINRMQAARYGLNIKDVQQIVSSAIGGENIG 757
Cdd:TIGR00915 680 FDFFLQDRAGLgheallqarnQLLGLAAQNPALTRVRPNGLEDEPQLKIDIDREKAQALGVSIADINTTLSTAWGSSYVN 759
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 758 ETVEGLARDPINVRYPREIRDSLEALRNLPILTESGQQIVLSSVANIQITDGPPMLKSENARPSgwiyVDVQGRDLASV- 836
Cdd:TIGR00915 760 DFIDRGRVKRVYVQAEEDARMSPEDINKWYVRNASGEMVPFSAFATVRWEYGSPQLERYNGLPS----MEILGSAAPGVs 835
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 837 ---VQDLKQAIDQKVkrSSAMSISYSGQfEFMER-ANARLKVVIPITLMIIFLLLYLIFRQVQDAVLIMATLPFALIGGI 912
Cdd:TIGR00915 836 tgqAMAAMEAIAQKL--PPGFGFSWTGM-SYEERlSGSQAPALYALSLLVVFLCLAALYESWSIPVSVMLVVPLGIIGAL 912
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 913 WAMYLSDYHFSVAIAVGFIALAGVAAEFGVVMLFYLKQAIEHAqqslssstaslteQQLNKAIHTGAVLRVRPKAMTVAV 992
Cdd:TIGR00915 913 LATTLRGLSNDVYFQVGLLTTIGLSAKNAILIVEFAKELMAQG-------------KSIVEAALEAARLRLRPILMTSLA 979
|
1050 1060 1070 1080 1090
....*....|....*....|....*....|....*....|....*....|....
gi 727723773 993 ILAGLIPILLGTGTGSELMSRIALPMVGGMISAPLLSMFVIPAAYqLLIKRKLS 1046
Cdd:TIGR00915 980 FILGVVPLAISTGAGSGSQHAIGTGVFGGMVTATVLAIFFVPLFY-VVVRRLFK 1032
|
|
| PRK09579 |
PRK09579 |
multidrug efflux RND transporter permease subunit; |
27-1043 |
1.20e-66 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169983 [Multi-domain] Cd Length: 1017 Bit Score: 243.59 E-value: 1.20e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 27 GTWAVKNTPVDALPDLSDVQVIIRTNFSGQAPQIVENQVTYPLTTTMLSVPGVKTVRGYSF--FGDSFVYVIFDEHTDLY 104
Cdd:PRK09579 25 GFQAWSKLQIRQYPQMENALITVTTAYPGANAETIQGYITQPLQQSLASAEGIDYMTSVSRqnFSIISIYARIGADSDRL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 105 WarSRVLEYLNQIQGKMPANAK----SSLGPDATGVGWV--YEYALVDPTGQHDLSelRSIQDwflkyELKTLPNVAEVA 178
Cdd:PRK09579 105 F--TELLAKANEVKNQLPQDAEdpvlSKEAADASALMYIsfYSEEMSNPQITDYLS--RVIQP-----KLATLPGMAEAE 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 179 TIGGMVKQYQVVLDPSKMATLGVTQNNVIEAIQKAN-QETGGSVlemaETEYMV---RASGYLKTLDDFRQIPLRTNSfG 254
Cdd:PRK09579 176 ILGNQVFAMRLWLDPVKLAGFGLSAGDVTQAVRRYNfLSAAGEV----KGEYVVtsiNASTELKSAEAFAAIPVKTSG-D 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 255 VPVSLGDVATIQLGPEMRRGISELNGQGETVGGVVILRAGkNARETITAVKAKLAELQQSLPKGVQVVPVYDRSQLIDRA 334
Cdd:PRK09579 251 SRVLLGDVARVEMGAENYDSISSFDGIPSVYIGIKATPSA-NPLDVIKEVRAIMPELESQLPPNLKVSIAYDATLFIQAS 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 335 VENLSHKLIEEFIVVALVCGLFLWHLRSAMVAIVSLPLGILSAFLVMHYQGLNANIMSLGGIAIAIGAMVDAAIVMVENA 414
Cdd:PRK09579 330 IDEVVKTLGEAVLIVIVVVFLFLGALRSVLIPVVTIPLSMIGVLFFMQMMGYSINLLTLLAMVLAIGLVVDDAIVVVENI 409
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 415 HKHIEtwqhehpeqvlEAQVRWNIITRSASEVGPTLFFCLLIITLSFIPIFTLQAQEGRLFSPLAFTKTYAMAAAAGLSI 494
Cdd:PRK09579 410 HRHIE-----------EGKSPFDAALEGAREIAMPVVSMTITLAAVYAPIGFLTGLTGALFKEFALTLAGAVIISGIVAL 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 495 TLIPVLMGYWIR-GKLPSEQRNPLNRF---LIKIYSPMLDKVL-AHPKTILLGALLIFLISLFpLTRLGGEFLPNMDEGD 569
Cdd:PRK09579 479 TLSPMMCALLLRhEENPSGLAHRLDRLferLKQRYQRALHGTLnTRPVVLVFAVIVLALIPVL-LKFTQSELAPEEDQGI 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 570 LLYMPSALPGLSAAKASELLQQTDRMIKTVPEVATVFGKAGraesatdsapLEMFETTIQ---FKPRSEW-RSGMTPDKL 645
Cdd:PRK09579 558 IFMMSSSPQPANLDYLNAYTDEFTPIFKSFPEYYSSFQING----------FNGVQSGIGgflLKPWNEReRTQMELLPL 627
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 646 IKEldKAVQVPGLTNIWVppirNRIDMLATGVKSPIGIKV-SANDLQDIDRVAQQIEQVAkQVPGVSSALSERLTGGR-Y 723
Cdd:PRK09579 628 VQA--KLEEIPGLQIFGF----NLPSLPGTGEGLPFQFVInTANDYESLLQVAQRVKQRA-QESGKFAFLDIDLAFDKpE 700
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 724 VDVDINRMQAARYGLNIKDVQQIVSSAIGGENIGE-TVEGLARDPInVRYPREIRDSLEALRNLPILTESGQQIVLSSVA 802
Cdd:PRK09579 701 VVVDIDRAKAAQMGVSMQDLGGTLATLLGEGEINRfTIDGRSYKVI-AQVERPYRDNPGWLNNYYVKNEQGQLLPLSTLI 779
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 803 NIQITDGPPMLKSENARPSGWIyvdvQGRDLASvvqdLKQAID--QKVKRSSA---MSISYSG-QFEFMERANArLKVVI 876
Cdd:PRK09579 780 TLSDRARPRQLNQFQQLNSAII----SGFPIVS----MGEAIEtvQQIAREEApegFAFDYAGaSRQYVQEGSA-LWVTF 850
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 877 PITLMIIFLLLYLIFRQVQDAVLIMATLPFALIGGIWAMYLSDYHFSVAIAVGFIALAGVAAEFGVVMLFYLKQAIEhaq 956
Cdd:PRK09579 851 GLALAIIFLVLAAQFESFRDPLVILVTVPLSICGALIPLFLGVSSMNIYTQVGLVTLIGLISKHGILIVEFANQLRH--- 927
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 957 qslssstasltEQQLN--KAIHTGAVLRVRPKAMTVAVILAGLIPILLGTGTGSELMSRIALPMVGGMISAPLLSMFVIP 1034
Cdd:PRK09579 928 -----------EQGLSrrEAIEEAAAIRLRPVLMTTAAMVFGMVPLILATGAGAVSRFDIGLVIATGMSIGTLFTLFVLP 996
|
....*....
gi 727723773 1035 AAYQLLIKR 1043
Cdd:PRK09579 997 CIYTLLAKP 1005
|
|
| PRK09577 |
PRK09577 |
multidrug efflux RND transporter permease subunit; |
7-1034 |
1.75e-62 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169981 [Multi-domain] Cd Length: 1032 Bit Score: 231.28 E-value: 1.75e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 7 RFSIANRVFVLLAALILAAWGTWAVKNTPVDALPDLSDVQVIIRTNFSGQAPQIVENQVTYPLTTTMLSVPGVKTVRGYS 86
Cdd:PRK09577 3 RFFIDRPVFAWVISLFIMLGGIFAIRALPVAQYPDIAPPVVSIYATYPGASAQVVEESVTALIEREMNGAPGLLYTSATS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 87 FFGDSFVYVIFDEHTDLYWARSRVLEYLNQIQGKMPANAKS---SLGPDATGVGWVYeyALVDPTGQHDLSELRSIQDWF 163
Cdd:PRK09577 83 SAGQASLSLTFKQGVNADLAAVEVQNRLKTVEARLPEPVRRdgiQVEKAADNIQLIV--SLTSDDGRLTGVELGEYASAN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 164 LKYELKTLPNVAEVATIGGmvkQYQVVL--DPSKMATLGVTQNNVIEAIQKANQE-TGG-----SVLEMAETEYMVRASG 235
Cdd:PRK09577 161 VLQALRRVEGVGKVQFWGA---EYAMRIwpDPVKLAALGLTASDIASAVRAHNARvTIGdigrsAVPDSAPIAATVFADA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 236 YLKTLDDFRQIPLRTNSFGVPVSLGDVATIQLGPEMRRGISELNGQGETvGGVVILRAGKNARETITAVKAKLAELQQSL 315
Cdd:PRK09577 238 PLKTPEDFGAIALRARADGSALYLRDVARIEFGGNDYNYPSYVNGKTAT-GMGIKLAPGSNAVATEKRVRATMDELSRYF 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 316 PKGVQVVPVYDRSQLIDRAVENLSHKLIEEFIVVALVCGLFLWHLRSAMVAIVSLPLGILSAFLVMHYQGLNANIMSLGG 395
Cdd:PRK09577 317 PPGVKYQIPYETSSFVRVSMNKVVTTLIEAGVLVFLVMFLFMQNFRATLIPTLVVPVALLGTFGVMLAAGFSINVLTMFG 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 396 IAIAIGAMVDAAIVMVENahkhIETWQHEHPEQVLEAQVRwNIITRSASEVGPTlffclLIITLSFIPIFTLQAQEGRLF 475
Cdd:PRK09577 397 MVLAIGILVDDAIVVVEN----VERLMVEEGLSPYDATVK-AMKQISGAIVGIT-----VVLTSVFVPMAFFGGAVGNIY 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 476 SPLAFTKTYAMAAAAGLSITLIPVLMGYWIRgklPSEQRNP--------LNRFLIKI---YSPMLDKVLAHPKTILLGAL 544
Cdd:PRK09577 467 RQFALSLAVSIGFSAFLALSLTPALCATLLK---PVDGDHHekrgffgwFNRFVARStqrYATRVGAILKRPLRWLVVYG 543
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 545 LIFLISLFPLTRLGGEFLPNMDEGDLLYMPSALPGLSAAKASELLQQTDRMIKTVPEVATVFGKAGRAESATDSAPLEMF 624
Cdd:PRK09577 544 ALTAAAALLFTRLPTAFLPDEDQGNFMVMVIRPQGTPLAETMQSVREVESYLRRHEPVAYTFALGGFNLYGEGPNGGMIF 623
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 625 ETTIQFKPRSEWRSGMtpDKLIKELDKavQVPGLTNIWV-----PPIRnriDMLATGvkspiGIKVSANDLQDIDRVA-- 697
Cdd:PRK09577 624 VTLKDWKERKAARDHV--QAIVARINE--RFAGTPNTTVfamnsPALP---DLGSTS-----GFDFRLQDRGGLGYAAfv 691
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 698 ---QQIEQVAKQVPGVSSALSERLTGGRYVDVDINRMQAARYGLNIKDVQQIVSSAIGGENIGETVEGLARDPINVRYPR 774
Cdd:PRK09577 692 aarEQLLAEGAKDPALTDLMFAGTQDAPQLKLDIDRAKASALGVSMDEINTTLAVMFGSDYIGDFMHGSQVRRVIVQADG 771
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 775 EIRDSLEALRNLPILTESGQQIVLSSVANIQITDGPPMLKSENARPSGWIYVDVQ-GRDLASVVQDLKQaIDQKVKRSSA 853
Cdd:PRK09577 772 RHRLDPDDVKKLRVRNAQGEMVPLAAFATLHWTLGPPQLTRYNGYPSFTINGSAApGHSSGEAMAAIER-IAATLPAGIG 850
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 854 MsiSYSGQfEFMER-ANARLKVVIPITLMIIFLLLYLIFRQVQDAVLIMATLPFALIGGIWAMYLSDYHFSVAIAVGFIA 932
Cdd:PRK09577 851 Y--AWSGQ-SFEERlSGAQAPMLFALSVLVVFLALAALYESWSIPFAVMLVVPLGVIGAVLGVTLRGMPNDIYFKVGLIA 927
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 933 LAGVAAEFGVVMLFYLKQAIEHAQqslssstaslteqQLNKAIHTGAVLRVRPKAMTVAVILAGLIPILLGTGTGSELMS 1012
Cdd:PRK09577 928 TIGLSAKNAILIVEVAKDLVAQRM-------------SLADAALEAARLRLRPIVMTSLAFGVGVLPLAFASGAASGAQI 994
|
1050 1060
....*....|....*....|..
gi 727723773 1013 RIALPMVGGMISAPLLSMFVIP 1034
Cdd:PRK09577 995 AIGTGVLGGVITATVLAVFLVP 1016
|
|
| PRK10614 |
PRK10614 |
multidrug efflux system subunit MdtC; Provisional |
35-1037 |
1.80e-62 |
|
multidrug efflux system subunit MdtC; Provisional
Pssm-ID: 182589 [Multi-domain] Cd Length: 1025 Bit Score: 231.15 E-value: 1.80e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 35 PVDALPDLSDVQVIIRTNFSGQAPQIVENQVTYPLTTTMLSVPGVKTVRGYSFFGDSFVYVIFDEHTDLYWARSRVLEYL 114
Cdd:PRK10614 33 PVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVNEMTSSSSLGSTRIILQFDFDRDINGAARDVQAAI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 115 NQIQGKMPANAKS-----------------SLGPDATGVGWVYEYAlvdptgqhdlselrSIQdwfLKYELKTLPNVAEV 177
Cdd:PRK10614 113 NAAQSLLPSGMPSrptyrkanpsdapimilTLTSDTYSQGQLYDFA--------------STQ---LAQTISQIDGVGDV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 178 ATIGGMVKQYQVVLDPSKMATLGVTQNNVIEAIQKANQETGGSVLEMAETEYMVRASGYLKTLDDFRQIPLRTNSfGVPV 257
Cdd:PRK10614 176 DVGGSSLPAVRVGLNPQALFNQGVSLDDVRQAISNANVRRPQGAVEDGTHRWQIQTNDELKTAAEYQPLIIHYNN-GAAV 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 258 SLGDVATIQLGPEMRRGISELNGQGETVggVVILR-AGKNARETITAVKAKLAELQQSLPKGVQVVPVYDRSQLIDRAVE 336
Cdd:PRK10614 255 RLGDVATVTDSVQDVRNAGMTNAKPAIL--LMIRKlPEANIIQTVDRIRAKLPELRETIPAAIDLQIAQDRSPTIRASLE 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 337 NLSHKLIEEFIVVALVCGLFLWHLRSAMVAIVSLPLGILSAFLVMHYQGLNANIMSLGGIAIAIGAMVDAAIVMVENAHK 416
Cdd:PRK10614 333 EVEQTLAISVALVILVVFLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENISR 412
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 417 HIETWQheHPEQVLEAQVRwniitrsasEVGPTLFFCLLIITLSFIPIFTLQAQEGRLFSPLAFTKTYAMAAAAGLSITL 496
Cdd:PRK10614 413 HLEAGM--KPLQAALQGVR---------EVGFTVLSMSLSLVAVFLPLLLMGGLPGRLFREFAVTLSVAIGISLLVSLTL 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 497 IPVLMGYWIRGKLPSEQRNP--LNRFLIKI---YSPMLDKVLAHPKTILLGALLIFLISLFPLTRLGGEFLPNMDEGDLL 571
Cdd:PRK10614 482 TPMMCAWLLKSSKPREQKRLrgFGRMLVALqqgYGRSLKWVLNHTRWVGVVLLGTIALNVWLYISIPKTFFPEQDTGRLM 561
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 572 YMPSALPGLSAAKASELLQQTDRMIKTVPEVATVFGKAGRAESATDSapleMFettIQFKPRSEwRSgMTPDKLIKEL-D 650
Cdd:PRK10614 562 GFIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGSRVNSGM----MF---ITLKPLSE-RS-ETAQQVIDRLrV 632
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 651 KAVQVPGlTNIWVPPIRnriDMLATGVKSPIGIKVS--ANDLQDIDRVAQQIEQVAKQVPGVSSALSERLTGGRYVDVDI 728
Cdd:PRK10614 633 KLAKEPG-ANLFLMAVQ---DIRVGGRQSNASYQYTllSDDLAALREWEPKIRKALAALPELADVNSDQQDKGAEMALTY 708
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 729 NRMQAARYGLNIKDVQQIVSSAIGGENIGETVEGLAR-------DPinvRYPREIRdsleALRNLPILTESGQQIVLSSV 801
Cdd:PRK10614 709 DRDTMARLGIDVQAANSLLNNAFGQRQISTIYQPLNQykvvmevDP---RYTQDIS----ALEKMFVINNEGKAIPLSYF 781
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 802 ANIQITDGPpmlksenarpsgwIYVDVQGRDLASVVQ-------DLKQAIDQKVKRSSAMSI--SYSGQFE-----FMER 867
Cdd:PRK10614 782 AKWQPANAP-------------LSVNHQGLSAASTISfnlptgkSLSDASAAIERAMTQLGVpsTVRGSFAgtaqvFQET 848
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 868 ANARLkVVIPITLMIIFLLLYLIFRQVQDAVLIMATLPFALIGGIWAMYLSDYHFSVAIAVGFIALAGVAAEFGVVMLFY 947
Cdd:PRK10614 849 MNSQL-ILILAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDF 927
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 948 LKQAIEHAQQSLssstaslteqqlNKAIHTGAVLRVRPKAMTVAVILAGLIPILLGTGTGSELMSRIALPMVGGMISAPL 1027
Cdd:PRK10614 928 ALEAQRNGNLTA------------QEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGAELRQPLGITIVGGLVMSQL 995
|
1050
....*....|
gi 727723773 1028 LSMFVIPAAY 1037
Cdd:PRK10614 996 LTLYTTPVVY 1005
|
|
| PRK10503 |
PRK10503 |
MdtB/MuxB family multidrug efflux RND transporter permease subunit; |
35-1039 |
1.45e-58 |
|
MdtB/MuxB family multidrug efflux RND transporter permease subunit;
Pssm-ID: 182501 [Multi-domain] Cd Length: 1040 Bit Score: 219.22 E-value: 1.45e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 35 PVDALP--DLSDVQVIirTNFSGQAPQIVENQVTYPLTTTMLSVPGVKTVRGYSFFGDSFVYVIFDEHTDLYWARSRVle 112
Cdd:PRK10503 42 PVSALPevDYPTIQVV--TLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEV-- 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 113 ylnqiqgKMPANAKSSLGPDATGVGWVYeyALVDP-----------------TGQHDLSELRSIQdwflkyELKTLPNVA 175
Cdd:PRK10503 118 -------QAAINAATNLLPSDLPNPPVY--SKVNPadppimtlavtstampmTQVEDMVETRVAQ------KISQVSGVG 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 176 EVATIGGMVKQYQVVLDPSKMATLGVTQNNVIEAIQKANQETGGSVLEMAETEYMVRASGYLKTLDDFRQIPLRTNSfGV 255
Cdd:PRK10503 183 LVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPTRAVTLSANDQMQSAEEYRQLIIAYQN-GA 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 256 PVSLGDVATIQLGPEMRRGISELNGQGETVGGVViLRAGKNARETITAVKAKLAELQQSLPKGVQVVPVYDRSQLIDRAV 335
Cdd:PRK10503 262 PIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQ-RQPGANIIATADSIRQMLPQLTESLPKSVKVTVLSDRTTNIRASV 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 336 ENLSHKLIEEFIVVALVCGLFLWHLRSAMVAIVSLPLGILSAFLVMHYQGLNANIMSLGGIAIAIGAMVDAAIVMVENAH 415
Cdd:PRK10503 341 DDTQFELMLAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENIS 420
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 416 KHIEtwQHEHPeqvLEAQVrwniitRSASEVGPTlffcllIITLSF------IPIFTLQAQEGRLFSPLAFTKTYAMAAA 489
Cdd:PRK10503 421 RYIE--KGEKP---LAAAL------KGAGEIGFT------IISLTFsliavlIPLLFMGDIVGRLFREFAVTLAVAILIS 483
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 490 AGLSITLIPVLMGYWirgkLPSEQRNPLNRF----------LIKIYSPMLDKVLAHPKTILLGALLIFLISLFPLTRLGG 559
Cdd:PRK10503 484 AVVSLTLTPMMCARM----LSQESLRKQNRFsrasermfdrVIAAYGRGLAKVLNHPWLTLSVALSTLLLTVLLWIFIPK 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 560 EFLPNMDEGDLLYMPSALPGLSAAKASELLQQTDRMIKTVPEVA--TVFGKAGRAESATDSAPLEmfettIQFKPRSEWR 637
Cdd:PRK10503 560 GFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQslTSFVGVDGTNPSLNSARLQ-----INLKPLDERD 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 638 SGMtpDKLIKELDKAV-QVPGLTnIWVPPIRN-RIDMLATgvKSPIGIKVSANDLQDIDRVAQQIEQVAKQVPGVSSALS 715
Cdd:PRK10503 635 DRV--QKVIARLQTAVaKVPGVD-LYLQPTQDlTIDTQVS--RTQYQFTLQATSLDALSTWVPKLMEKLQQLPQLSDVSS 709
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 716 ERLTGGRYVDVDINRMQAARYGLNIKDVQQIVSSAIGGENIGETVEGLARDPINVRYPREIRDSLEALRNLPILTESGQQ 795
Cdd:PRK10503 710 DWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGV 789
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 796 IVLSSVANIQITDGPPMLKSENARPSGWIYVDV-QGRDLASVVQDLKQAiDQKVKRSSAMSISYSGQFEFMERA--NARL 872
Cdd:PRK10503 790 VPLSSIATIEQRFGPLSINHLDQFPSTTISFNVpDGYSLGDAVQAIMDT-EKTLNLPADITTQFQGSTLAFQSAlgSTVW 868
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 873 KVVIPITLMIIFL-LLYLIFRQvqdAVLIMATLPFALIGGIWAMYLSDYHFSVAIAVGFIALAGVAAEFGVVML-FYLKQ 950
Cdd:PRK10503 869 LIVAAVVAMYIVLgVLYESFIH---PITILSTLPTAGVGALLALMIAGSELDVIAIIGIILLIGIVKKNAIMMIdFALAA 945
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 951 AIEHAQQSLssstaslteqqlnKAIHTGAVLRVRPKAMTVAVILAGLIPILLGTGTGSELMSRIALPMVGGMISAPLLSM 1030
Cdd:PRK10503 946 EREQGMSPR-------------DAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGICMVGGLIVSQVLTL 1012
|
....*....
gi 727723773 1031 FVIPAAYQL 1039
Cdd:PRK10503 1013 FTTPVIYLL 1021
|
|
| PRK15127 |
PRK15127 |
multidrug efflux RND transporter permease subunit AcrB; |
7-1048 |
9.75e-56 |
|
multidrug efflux RND transporter permease subunit AcrB;
Pssm-ID: 185081 [Multi-domain] Cd Length: 1049 Bit Score: 210.53 E-value: 9.75e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 7 RFSIANRVFVLLAALILAAWGTWAVKNTPVDALPDLSDVQVIIRTNFSGQAPQIVENQVTYPLTTTMLSVPGVKTVRGYS 86
Cdd:PRK15127 3 NFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 87 -FFGDSFVYVIFDEHTDLYWARSRVLeylNQIQGKMPANAKS------SLGPDATGVGWVYEYALVDPT-GQHDLSELRS 158
Cdd:PRK15127 83 dSTGTVQITLTFESGTDADIAQVQVQ---NKLQLAMPLLPQEvqqqgvSVEKSSSSFLMVVGVINTDGTmTQEDISDYVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 159 IQdwfLKYELKTLPNVAEVATIGGmvkQY--QVVLDPSKMATLGVTQNNVIEAIQKAN------QETGGSVLEMAETEYM 230
Cdd:PRK15127 160 AN---MKDPISRTSGVGDVQLFGS---QYamRIWMNPNELNKFQLTPVDVINAIKAQNaqvaagQLGGTPPVKGQQLNAS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 231 VRASGYLKTLDDFRQIPLRTNSFGVPVSLGDVATIQLGPEMRRGISELNGQGETVGGVViLRAGKNARETITAVKAKLAE 310
Cdd:PRK15127 234 IIAQTRLTSTEEFGKILLKVNQDGSRVRLRDVAKIELGGENYDIIAEFNGQPASGLGIK-LATGANALDTAAAIRAELAK 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 311 LQQSLPKGVQVVPVYDRSQLIDRAVENLSHKLIEEFIVVALVCGLFLWHLRSAMVAIVSLPLGILSAFLVMHYQGLNANI 390
Cdd:PRK15127 313 MEPFFPSGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINT 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 391 MSLGGIAIAIGAMVDAAIVMVENahkhIETWQHEHPEQVLEAQvrwniiTRSASEVGPTLFFCLLIITLSFIPIFTLQAQ 470
Cdd:PRK15127 393 LTMFGMVLAIGLLVDDAIVVVEN----VERVMAEEGLPPKEAT------RKSMGQIQGALVGIAMVLSAVFVPMAFFGGS 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 471 EGRLFSPLAFTKTYAMAAAAGLSITLIPVLMGYWIR-------GKLPSEQRNPLNRFLIKI---YSPMLDKVLAHPKTIL 540
Cdd:PRK15127 463 TGAIYRQFSITIVSAMALSVLVALILTPALCATMLKpiakgdhGEGKKGFFGWFNRMFEKSthhYTDSVGNILRSTGRYL 542
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 541 LGALLIFLISLFPLTRLGGEFLPNMDEGDLLYMPSALPGLSAAKASELLQQ-TDRMI----KTVPEVATV--FGKAGRAE 613
Cdd:PRK15127 543 VLYLIIVVGMAYLFVRLPSSFLPDEDQGVFLTMVQLPAGATQERTQKVLNEvTDYYLtkekNNVESVFAVngFGFAGRGQ 622
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 614 SatdsaplemfeTTIQFKPRSEW--RSGmtpdklikeldKAVQVPGLTNIWVPPIRNRIDMLATGVKSPIGIKV---SAN 688
Cdd:PRK15127 623 N-----------TGIAFVSLKDWadRPG-----------EENKVEAITMRATRAFSQIKDAMVFAFNLPAIVELgtaTGF 680
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 689 DLQDIDRVA---QQIEQVAKQVPGVSSALSERLTGGR--------YVDVDINRMQAARYGLNIKDVQQIVSSAIGGENIG 757
Cdd:PRK15127 681 DFELIDQAGlghEKLTQARNQLLGEAAKHPDMLVGVRpngledtpQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYVN 760
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 758 ETVEGLARDPINVRYPREIRDSLEALRNLPILTESGQQIVLSSVANIQITDGPPMLKSENARPSGWIYVDVQGRDLASVV 837
Cdd:PRK15127 761 DFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEA 840
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 838 QDLKQAIDQKVkrSSAMSISYSGqFEFMERANA-RLKVVIPITLMIIFLLLYLIFRQVQDAVLIMATLPFALIGGIWAMY 916
Cdd:PRK15127 841 MELMEELASKL--PTGVGYDWTG-MSYQERLSGnQAPALYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAAT 917
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 917 LSDYHFSVAIAVGFIALAGVAAEFGVVMLFYLKQAIEHAQqslssstaslteQQLNKAIHTGAVLRVRPKAMTVAVILAG 996
Cdd:PRK15127 918 FRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEG------------KGLIEATLEAVRMRLRPILMTSLAFILG 985
|
1050 1060 1070 1080 1090
....*....|....*....|....*....|....*....|....*....|..
gi 727723773 997 LIPILLGTGTGSELMSRIALPMVGGMISAPLLSMFVIPAAYqLLIKRKLSKN 1048
Cdd:PRK15127 986 VMPLVISSGAGSGAQNAVGTGVMGGMVTATVLAIFFVPVFF-VVVRRRFSRK 1036
|
|
| PRK10555 |
PRK10555 |
multidrug efflux RND transporter permease AcrD; |
27-1043 |
1.54e-51 |
|
multidrug efflux RND transporter permease AcrD;
Pssm-ID: 182544 [Multi-domain] Cd Length: 1037 Bit Score: 197.36 E-value: 1.54e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 27 GTWAVKNTPVDALPDLSDVQVIIRTNFSGQAPQIVENQVTYPLTTTMLSVPGVKTVRGYSF-FGDSFVYVIFDEHTDLYW 105
Cdd:PRK10555 23 GTLAIFSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQSSgTGQASVTLSFKAGTDPDE 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 106 ARSRVLEYLNQIQGKMPANAKSS-LGPDATGVGWVYEYALVDPTGQHDLSElrsIQDWFLKYELKTLPNVAEVATIGGMV 184
Cdd:PRK10555 103 AVQQVQNQLQSAMRKLPQAVQNQgVTVRKTGDTNILTIAFVSTDGSMDKQD---IADYVASNIQDPLSRVNGVGDIDAYG 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 185 KQY--QVVLDPSKMATLGVTQNNVIEAIQKANQET-----GG--SVLEMAeTEYMVRASGYLKTLDDFRQIPLRTNSFGV 255
Cdd:PRK10555 180 SQYsmRIWLDPAKLNSFQMTTKDVTDAIESQNAQIavgqlGGtpSVDKQA-LNATINAQSLLQTPEQFRDITLRVNQDGS 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 256 PVSLGDVATIQLGPEMRRGISELNGQGETvGGVVILRAGKNARETITAVKAKLAELQQSLPKGVQVVPVYDRSQLIDRAV 335
Cdd:PRK10555 259 EVTLGDVATVELGAEKYDYLSRFNGKPAS-GLGVKLASGANEMATAKLVLNRLDELAQYFPHGLEYKVAYETTSFVKASI 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 336 ENLSHKLIEEFIVVALVCGLFLWHLRSAMVAIVSLPLGILSAFLVMHYQGLNANIMSLGGIAIAIGAMVDAAIVMVENAH 415
Cdd:PRK10555 338 EDVVKTLLEAIALVFLVMYLFLQNFRATLIPTIAVPVVLMGTFSVLYAFGYSINTLTMFAMVLAIGLLVDDAIVVVENVE 417
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 416 KhIETWQHEHPEQVleaqvrwniiTR-SASEVGPTLFFCLLIITLSFIPIFTLQAQEGRLFSPLAFTKTYAMAAAAGLSI 494
Cdd:PRK10555 418 R-IMSEEGLTPREA----------TRkSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVSAMVLSVLVAM 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 495 TLIPVLMGYWIRGKLPSEQRNP------LNRFLIKI---YSPMLDKVLAHPKTILLGALLIFLISLFPLTRLGGEFLPNM 565
Cdd:PRK10555 487 ILTPALCATLLKPLKKGEHHGQkgffgwFNRMFNRNaerYEKGVAKILHRSLRWILIYVLLLGGMVFLFLRLPTSFLPLE 566
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 566 DEGDLLYMPSALPGLSAAKASELLQQTDR--MIKTVPEVATVFGKAGRAESATDSAPLEMFettIQFKPRSEwRSGM--T 641
Cdd:PRK10555 567 DRGMFTTSVQLPSGSTQQQTLKVVEKVEKyyFTHEKDNVMSVFATVGSGPGGNGQNVARMF---IRLKDWDE-RDSKtgT 642
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 642 PDKLIKELDKAvqvpgLTNIwvppirNRIDMLATGVKSPIGIKVSAN---DLQD--------IDRVAQQIEQVAKQVPGV 710
Cdd:PRK10555 643 SFAIIERATKA-----FNKI------KEARVIASSPPAISGLGSSAGfdmELQDhagaghdaLMAARNQLLALAAKNPEL 711
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 711 SSALSERLTGGRYVDVDINRMQAARYGLNIKDVQQIVSSAIGGENIGETVEglaRDPINVRYPReirdSLEALRNLP--- 787
Cdd:PRK10555 712 TRVRHNGLDDSPQLQIDIDQRKAQALGVSIDDINDTLQTAWGSSYVNDFMD---RGRVKKVYVQ----AAAPYRMLPddi 784
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 788 ----ILTESGQQIVLSSVANIQITDGPPMLKsenaRPSGWIYVDVQGRDLASVVQDLKQAIDQKVKRS--SAMSISYSGQ 861
Cdd:PRK10555 785 nlwyVRNKDGGMVPFSAFATSRWETGSPRLE----RYNGYSAVEIVGEAAPGVSTGTAMDIMESLVKQlpNGFGLEWTAM 860
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 862 fEFMER-ANARLKVVIPITLMIIFLLLYLIFRQVQDAVLIMATLPFALIGGIWAMYLSDYHFSVAIAVGFIALAGVAAEF 940
Cdd:PRK10555 861 -SYQERlSGAQAPALYAISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKN 939
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 941 GVVMLFYLKQAIEHAqqslssstaslteQQLNKAIHTGAVLRVRPKAMTVAVILAGLIPILLGTGTGSELMSRIALPMVG 1020
Cdd:PRK10555 940 AILIVEFANEMNQKG-------------HDLFEATLHASRQRLRPILMTSLAFIFGVLPMATSTGAGSGSQHAVGTGVMG 1006
|
1050 1060
....*....|....*....|...
gi 727723773 1021 GMISAPLLSMFVIPAAYQLLIKR 1043
Cdd:PRK10555 1007 GMISATILAIFFVPLFFVLVRRR 1029
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
3-414 |
1.23e-15 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 82.07 E-value: 1.23e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 3 ARIIRFSIANRVFVLLAALILAAWGTWAVKNTPVDALP--DLSDVQVIIRTNfSGQAPQIVEnQVTYPLTTTMLSVPGVK 80
Cdd:COG0841 516 GRLLRWALRHRKLTLLVALALLALSVLLFGRLPTEFFPeeDQGQIIVSVQLP-PGTSLERTE-AVVRQVEEILLEVPEVE 593
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 81 TVR---GYSFFGDS----FVYVIFDEHTDlywaRSR-VLEYLNQIQGKMP--ANAKSSL---GPDATGVGWVYEYALVDP 147
Cdd:COG0841 594 SVFsvvGFSGGGSGsnsgTIFVTLKPWDE----RDRsADEIIARLREKLAkiPGARVFVfqpPAGGLGSGAPIEVQLQGD 669
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 148 tgqhDLSELRSIQDWFLKyELKTLPNVAEVATIGGMVK-QYQVVLDPSKMATLGVTQNNVIEAIQKAnqeTGGSV---LE 223
Cdd:COG0841 670 ----DLEELAAAAEKLLA-ALRQIPGLVDVRSDLQLGKpELQLDIDREKAAALGVTVADVASTLRAA---LGGRYvndFN 741
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 224 MAETEY--MVRA-SGYLKTLDDFRQIPLRTNSfGVPVSLGDVATIQLGPEMRRgISELNGQGE-TVGGVVilRAGKNARE 299
Cdd:COG0841 742 RGGREYdvRVQApEEDRNSPEDLENLYVRTPD-GEMVPLSSVATIEEGTGPSS-INRYNGQRSvTVSANL--APGVSLGE 817
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 300 TITAVKAKLAELQqsLPKGVQVVPVYDrSQLIDRAVENLSHKLIEEFIVVALVCGLFLWHLRSAMVAIVSLPLGILSAFL 379
Cdd:COG0841 818 ALAAIEELAAELK--LPPGVSIEFTGQ-AEEEQESFSSLGLAFLLALLLVYLVLAAQFESFIQPLIILLTVPLALIGALL 894
|
410 420 430
....*....|....*....|....*....|....*
gi 727723773 380 VMHYQGLNANIMSLGGIAIAIGAMVDAAIVMVENA 414
Cdd:COG0841 895 GLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVDFA 929
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
3-432 |
1.69e-09 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 61.93 E-value: 1.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 3 ARIIRFSIANRVFVLLAALILAAWGTWAVKNTPVDALPDLsDVQVIIrtnFSGQAPQIVE----NQVTYPLTTTMLSVPG 78
Cdd:pfam00873 517 AKLLAKVLRHTAVVLLVALLLVVGSVWLFVRIPTEFLPEE-DEGVFV---TSAQLPPGVSldqtQRVMKQVEKILKEKPE 592
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 79 VK---TVRGYSFFGD--------SFVYVI-FDEHTDLYWARSRVLEYLNQIQGKMPANAKSSLGPDA---TGVGWVYEYA 143
Cdd:pfam00873 593 VEsvfAVTGFAFSGDnngpnsgdAFISLKpWKERPGPEKSVQALIERLRKALKQIPGANVFLFQPIQlrgLGTISGFRSD 672
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 144 LVDPTGQHDLSELRSIQDWFLKyELKTLPNVAEVATIGGM-VKQYQVVLDPSKMATLGVTQNNVIEAIQKAnqeTGGSV- 221
Cdd:pfam00873 673 LQVKIFGDDLDALDEARNQILA-ALAQLPGLSDVRSDGQEdQPQLQVNIDREKAARLGVSIQDINDTLSTA---LGGSYv 748
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 222 ----LEMAETEYMVRA-SGYLKTLDDFRQIPLRTNSfGVPVSLGDVATIQLGPEMRRgISELNGQGEtvggVVIL---RA 293
Cdd:pfam00873 749 ndfpEGGRVYDVVVQLpEDFRSSPEDIGQLYVRNPY-GKMIPLSAFAKIEWGYGPPS-INRYNGFRS----IVISgnvAA 822
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 294 GKNARETITAVKAKLAELQqsLPKGVQVVPVYDRSQLIdRAVENLSHKLIEEFIVVALVCGLFLWHLRSAMVAIVSLPLG 373
Cdd:pfam00873 823 GDSLGDAMEAMAQIAKQVK--LPPGYGYTWTGQFEQEQ-LAGNSLPILIALALLVVFLVLAALYESWSDPLSIMLTVPLA 899
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 727723773 374 ILSAFLVMHYQGLNANIMSLGGIAIAIGAMVDAAIVMVENAHKHIETWQHEHPEQVLEA 432
Cdd:pfam00873 900 LVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVEFANELREQEGKSLEEAILEA 958
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
346-501 |
2.77e-08 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 57.95 E-value: 2.77e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 346 FIVVALVCGLFLWHLRSAMVAIVSLPLGILSAFLVMHYQGLNANIMSLGGIAIAIGAMVDAAIVMVenaHKHIETWQHEH 425
Cdd:COG1033 615 LLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFL---SRYREERRKGG 691
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 426 PeqVLEAqvrwniITRSASEVGPTLFFCLLIITLSFIP----IFTLQAQEGRLfspLAFTKTYAMAAAaglsITLIPVLM 501
Cdd:COG1033 692 D--LEEA------IRRALRTTGKAILFTSLTLAAGFGVllfsSFPPLADFGLL---LALGLLVALLAA----LLLLPALL 756
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
535-931 |
4.93e-08 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 57.33 E-value: 4.93e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 535 HPKTILLGALLIFLISLFPLTRLGGEFLPNMDEgDLLYMPSALPGLSAakasELLQQTdrmIKTVPEVAtvFGKAGRAES 614
Cdd:NF033617 7 RPVATLLLSLLILLLGLLAFRKLPVREYPEVDF-PTITVSTSYPGASP----ELMQSS---ITQPLEQQ--LAQIEGIDE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 615 ATDSAPLEMFETTIQFkprsewRSGMTPDKLIKELDKAVQV------PGLTNiwvPPIRNRIDMLATGVkspIGIKVSAN 688
Cdd:NF033617 77 MTSQSSLGYSTITLQF------RLGTDLDVALSEVQAAINAaqsllpSEAPD---PPVYRKANSADTPI---MYIGLTSE 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 689 DL---QDIDRVAQQIEQVAKQVPGVSSAlseRLTGGRY--VDVDINRMQAARYGLNIKDVQQIVSSA----IGGENIGET 759
Cdd:NF033617 145 EMprgQLTDYAERVLAPKLSQINGVGSV---DVSGGQRpaMRVWLDPEKMAARGLTADDVRSALNSNnvnsPKGAVRGDS 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 760 VEglardpINVRYPREIRdSLEALRNLPI-LTESGQQIVLSSVANiqITDGPpmlksENARPSGW------IYVDVQGRD 832
Cdd:NF033617 222 VV------STVRANDQLK-TAEDYEDLVIkYADNGAPVRLGDVAT--VELGA-----ENVRNRAWangvpaVVLGINRQP 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 833 LA---SVVQDLKQAIDQKVK---RSSAMSISYSgQFEFMERANARLKVVIPITLMIIFLLLYLIFRQVQdAVLIMA-TLP 905
Cdd:NF033617 288 GAnpiEVADEIRALLPELQEtlpKNIKVNVLYD-RTRFIRASIDEVESTLLEAVALVILVVFLFLRNLR-ATLIPAvTVP 365
|
410 420 430
....*....|....*....|....*....|....
gi 727723773 906 FALIGGIWAMYLSDyhFSV--------AIAVGFI 931
Cdd:NF033617 366 LSLIGTFAVMYLFG--FSInlltlmalVLAIGLV 397
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
346-1047 |
2.58e-07 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 54.87 E-value: 2.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 346 FIVVALVCGLFLWHLRSAMVAIVSLPLGILSAFLVMHYQGLNANIMS--LGGIAIAIGamVDAAIVMVENAHKHIEtwQH 423
Cdd:COG1033 228 LLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTilVPPLLLAIG--IDYGIHLLNRYREERR--KG 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 424 EHPEQvleaqvrwnIITRSASEVGPTLFFCLLIITLSFipiFTLqaqegrLFSPLAFTKTYAMAAAAG------LSITLI 497
Cdd:COG1033 304 LDKRE---------ALREALRKLGPPVLLTSLTTAIGF---LSL------LFSDIPPIRDFGIVAAIGvllaflTSLTLL 365
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 498 PVLMGY---WIRGKLPSEQRNPLNRFLIKIyspmLDKVLAHPKTILLGALLIFLISLFPLTRlggeflpnmdegdllymp 574
Cdd:COG1033 366 PALLSLlprPKPKTRRLKKPPELGRLLAKL----ARFVLRRPKVILVVALVLAVVSLYGISR------------------ 423
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 575 salpglsaakaselLQQTDRMIKTVPEvatvfgkagraesatdsaplemfettiqfkpRSEWRSGMtpDKLIKELDKAVQ 654
Cdd:COG1033 424 --------------LKVEYDFEDYLPE-------------------------------DSPIRQDL--DFIEENFGGSDP 456
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 655 VpgltNIWVPPIRNRidmlatGVKSPigikvsaNDLQDIDRVAQQIEqvakQVPGVSSALSerltggrYVDVdINRMQAA 734
Cdd:COG1033 457 L----EVVVDTGEPD------GLKDP-------EVLKEIDRLQDYLE----SLPEVGKVLS-------LADL-VKELNQA 507
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 735 RYGLNIKDvqqivssaiggenigetveglardpinvrypREIRDSLEALRNLPILTESGQQIVLSSVANIQITDGPPMLK 814
Cdd:COG1033 508 LNEGDPKY-------------------------------YALPESRELLAQLLLLLSSPPGDDLSRFVDEDYSAARVTVR 556
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 815 senarpsgwiYVDVQGRDLASVVQDLKQAIDQKVKrSSAMSISYSGQFEFMERANARL----KVVIPITLMIIFLLLYLI 890
Cdd:COG1033 557 ----------LKDLDSEEIKALVEEVRAFLAENFP-PDGVEVTLTGSAVLFAAINESViesqIRSLLLALLLIFLLLLLA 625
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 891 FRQVQDAVLIMATLPFALIGGIWAMYLSDYHFSVAIAVGF-IALaGVAAEFGVVMLFYLKQAIEHaqqslssstASLTEQ 969
Cdd:COG1033 626 FRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVAsIAL-GIGVDYTIHFLSRYREERRK---------GGDLEE 695
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 970 QLNKAIHT--GAVLrvrpkaMTVAVILAGLIPILLgtgtgSEL--MSRIALPMVGGMISAPLLSMFVIPAAYQLLIKRKL 1045
Cdd:COG1033 696 AIRRALRTtgKAIL------FTSLTLAAGFGVLLF-----SSFppLADFGLLLALGLLVALLAALLLLPALLLLLDPRIA 764
|
..
gi 727723773 1046 SK 1047
Cdd:COG1033 765 KK 766
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
831-1044 |
2.72e-07 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 54.87 E-value: 2.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 831 RDLASVVQDLKQAIDQKvkRSSAMSISYSGQF----EFMERANARLKVVIPITLMIIFLLLYLIFRQVQDAVLIMATLpf 906
Cdd:COG1033 177 LDRKEVVAEIRAIIAKY--EDPGVEVYLTGFPvlrgDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVV-- 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 907 aLIGGIWA---MYLSDYHFSVAIAVGFIALAGVAAEFGVVMLFYLKQAIEHaqqslssstaslteqQLNKAihtgavlrv 983
Cdd:COG1033 253 -LLAVIWTlglMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLNRYREERRK---------------GLDKR--------- 307
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727723773 984 rpKAMTVAVILAGlIPILLGTGT-----------GSELMSRIALPMVGGMISAPLLSMFVIPAAYQLLIKRK 1044
Cdd:COG1033 308 --EALREALRKLG-PPVLLTSLTtaigflsllfsDIPPIRDFGIVAAIGVLLAFLTSLTLLPALLSLLPRPK 376
|
|
| actII |
TIGR00833 |
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ... |
269-954 |
3.44e-07 |
|
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 129913 [Multi-domain] Cd Length: 910 Bit Score: 54.59 E-value: 3.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 269 PEMRRGISelNGQGETVGGVVILRAGKNARETITAVKAKLAELQQ-SLPKGVQVV------PVYDRSQLIDRAVenlshK 341
Cdd:TIGR00833 104 PEAAEGLR--SDDGKATIIIVNLAGEKGQKEAQEAINAVRRIVEQtNAPDGLTVHvtgplaTIADILESGDKDM-----N 176
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 342 LIEEFIVVALVCGLFLWHlRSAMVAIVSL-PLGILSA------FLVMHYQGLNANIMSLGGI-AIAIGAMVDAAIVMVEN 413
Cdd:TIGR00833 177 RITATTGIIVLIILLLVY-RSPITMLVPLvSVGFSVVvaqgivSLLGIPGLIGVNAQTTVLLtALVIGAGTDYAVFLTGR 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 414 AHKhiETWQHEHPEQVLEAQVR--WNIITRSASEVGPTlFFCLLiitLSFIPIFTlqaqegRLFSPLAFTKTYAMAAAag 491
Cdd:TIGR00833 256 YHE--ERRKGESLEEAAAEALRgtGKAILGSALTVAVA-FLALS---LARLPSFK------TLGVSCAVGVLVALLNA-- 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 492 lsITLIPVLMGYWIRGKLPSEQRNPLNRFLIKiyspMLDKVLAH-PKTILLGALLIFLISLFPLTRLGGEFlpnmdeGDL 570
Cdd:TIGR00833 322 --VTLTPALLTLEGREGLMKPGRKSKIRFIWR----RLGTAVVRrPWPILVTTLIISGVSLLALPLIRTGY------DDE 389
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 571 LYMPSALP---GLSAA---------KASELLQQTD----------------RMIKTVPEVATVFGKAGRAESATDSAPL- 621
Cdd:TIGR00833 390 KMIPTDLEsvqGYEAAdrhfpgnsmDPMVVMIKSDhdvrnpalladidrfeREIKAVPGINMVQETQRPDGVVIKKTYLt 469
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 622 --------EMFETTIQFKPRSEWRSGMTPD--KLIKELDKAVQVPGLTNIWVPPIRNRIDMLATGVKSPIGIKVSANDLQ 691
Cdd:TIGR00833 470 fqagnlgdQLDEFSDQLTSRQAYLLQDAEKiaEAIAGLRLVQAGMRLDGENLGQVSLAVRLMQQAISKLQGSAGDVFDIF 549
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 692 DIDRVAQQIEQVAKQVPGVSSALSERLTGGRYVDVDINrmQAARYGLNIKDVQQIVSSAIGGENIGETVEGLardPINVR 771
Cdd:TIGR00833 550 DPLRRFVAAIPECRANPVCSVAREIVQAADTVVSSAAK--LADAAGQLARGIADVASALSQVSGLPNALDGI---GTQLA 624
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 772 YPREIRDSLEALRNLPILTESGQQIVLSSVANIQITDGPPMLKSENARPSGWIYVDVQGRDLASVVQ-DLKQAIDQKVKR 850
Cdd:TIGR00833 625 QMRESAAGVQDLLNELSDYSMTMGKLKGNAMGVDFYAPPRIFTDPNFKAVLDYFLSPDGHAARLLVYgDGSPAGDQGAQE 704
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 851 SSAM----------------SISYSGQ----FEFMERANARLKVVIPITLMIIFLLLYLIFRQVQDAVLIMATLPFALIG 910
Cdd:TIGR00833 705 FNAIrtvaeeaiqradlepaKVELAGVsavnRDLRDLVNSDLGLISIITLAIVFMILALLLRAPVAPIVLIGSVALSYLW 784
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|
gi 727723773 911 GIWAMYLSDYHFSVA------IAVGFIALAGVAAEFGVVMLFYLKQAIEH 954
Cdd:TIGR00833 785 ALGLSVLAFQHILGAelhwsvLAGVFVLLVALGVDYNMLLVSRIKEESPA 834
|
|
| 2A0601 |
TIGR00914 |
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ... |
705-1047 |
2.12e-05 |
|
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 129992 [Multi-domain] Cd Length: 1051 Bit Score: 48.60 E-value: 2.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 705 KQVPGVSsalsERLTGGRYVD---VDINRMQAARYGLNIKDVQQIVSSAigGENIGETVEGLARDPINVRYPREIRdSLE 781
Cdd:TIGR00914 176 RTVPGVA----EVNSIGGYVKqflVAPDPEKLAAYGLSLADVVNALERN--NQNVGAGYIERRGEQYLVRAPGQVQ-SMD 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 782 ALRNLPILTESGQQIVLSSVANIQItdGPPM---LKSENARP----SGWIYVDVQGRDLASVVQDLKQAIDQKVKRSSAM 854
Cdd:TIGR00914 249 DIRNIVIATGEGVPIRIRDVARVQI--GKELrtgAATENGKEvvlgTVFMLIGENSRTVAQAVGDKLETINKTLPEGVEI 326
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 855 SISYSgQFEFMERANARLKVVIPITLMIIFLLLYLIFRQVQDAVLIMATLPFALIggIWAMYLSDYHFSVAI-AVGFIAL 933
Cdd:TIGR00914 327 VTTYD-RSQLVDAAIATVKKNLLEGALLVIVILFLFLGNIRAALIAATVIPLSLL--ITFIGMVFQGISANLmSLGALDF 403
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 934 aGVAAEFGVVMLfylKQAIEHAQQSLSSSTASLTEQQLNKAIHTGAVLRVRPKAMTVAVILAGLIPILLGTGTGSELMSR 1013
Cdd:TIGR00914 404 -GLIVDGAVVIV---ENAHRRLAEAQHHHGRQLTLKERLHEVFAASREVRRPLIFGQLIITLVFLPIFTLTGVEGKMFHP 479
|
330 340 350
....*....|....*....|....*....|....
gi 727723773 1014 IALPMVGGMISAPLLSMFVIPAAYQLLIKRKLSK 1047
Cdd:TIGR00914 480 MAFTVVLALAGAMILSLTFVPAAVALFIRGKVAE 513
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
293-557 |
3.74e-03 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 41.29 E-value: 3.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 293 AGKNARETITAVKAKLAELQQSLPKGVQVV---PVYDRSQLIDRAVENLShklIEEFIVVALVCGLFLWHLRSA------ 363
Cdd:COG2409 123 DGDAGDEAAEAVDALRDAVAAAPAPGLTVYvtgPAALAADLNEAFEEDLG---RAELITLPVALVVLLLVFRSLvaallp 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 364 -MVAIVSLPLGILSAFLVMHYQGLNA---NIMSLGGIAIAIgamvDAAIVMVeNAHKhietwqhehpEQVLEAQVRWNII 439
Cdd:COG2409 200 lLTAGLAVGVALGLLALLAAFTDVSSfapNLLTMLGLGVGI----DYALFLV-SRYR----------EELRAGEDREEAV 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 440 TRSASEVGPTLFFCLLIITLSFIpiftlqaqeGRLFSPLAFTKTYAMAAAAG------LSITLIPVLMG------YWIRG 507
Cdd:COG2409 265 ARAVATAGRAVLFSGLTVAIALL---------GLLLAGLPFLRSMGPAAAIGvavavlAALTLLPALLAllgrrvFWPRR 335
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 727723773 508 KLPSEQRNPLNRFLIKIyspmLDKVLAHPKTILLGALLIFLISLFPLTRL 557
Cdd:COG2409 336 PRRRRAAAPESGFWRRL----ARAVVRRPVPVLVAAVAVLLALALPALGL 381
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
862-1039 |
6.90e-03 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 40.59 E-value: 6.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 862 FEFMERANARLKVVIPITLMIIFLLLYLIFRQVQDAVLIMATLPFALIGGIWAMYLSDYHFSVAIAVGFIALAGVAAEFG 941
Cdd:TIGR00921 185 YDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYG 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 942 VVMLFYLKQAIEhaqqslsssTASLTEQQLNKAIHTGAVLRVRPKAMTVAVILAGLIPILlgtgtgsELMSRIALPMVGG 1021
Cdd:TIGR00921 265 IQTLNRYEEERD---------IGRAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEF-------PMVSEFGLGLVAG 328
|
170
....*....|....*...
gi 727723773 1022 MISAPLLSMFVIPAAYQL 1039
Cdd:TIGR00921 329 LITAYLLTLLVLPALLQS 346
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
275-417 |
7.30e-03 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 40.22 E-value: 7.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727723773 275 ISELNGQgetVGGVVILRAGKNARetitAVKAKLAELQqslpkGVQVVpvyDRSQLIDRAVENLSHKLIE-EFIVVALVC 353
Cdd:COG4258 589 LGRKDGQ---WAALVPLRGVDDAA----ALRAAAAGLP-----GVRLV---DRKAESSSLFGRYRNDALWlLLLALLLIL 653
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727723773 354 GLFLWHLRSAM-VAIVSLPLgILSAFLV---MHYQGLNANIMSLGGIAIAIGAMVDAAIVMVENAHKH 417
Cdd:COG4258 654 LLLLLRLRSLRrALRVLLPP-LLAVLLTlaiLGLLGIPLNLFHLIALLLVLGIGIDYALFFTEGLLDK 720
|
|
| |
