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Conserved domains on  [gi|730422557|ref|WP_034011925|]
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MULTISPECIES: P-type DNA transfer ATPase VirB11 [Pseudomonadaceae]

Protein Classification

P-loop NTPase family protein( domain architecture ID 1562424)

P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 26-341 5.81e-120

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member TIGR02788:

Pssm-ID: 476819  Cd Length: 308  Bit Score: 348.57  E-value: 5.81e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557   26 LERGDVVEVTINRPGELWAKTFQGWEPVKVPELTMPYLKSLANAIAVFNGISLAS---ITSVVLPGGQRGQIVLPPACID 102
Cdd:TIGR02788   2 LDDEDVTEICINRPGEVWVEGPGGWQRFDVPDLTFSHLMRLARAIASFSKQSISEenpILSATLPGGERVQIVIPPACEN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557  103 DTLSLSIRKHSLVVKTLDELDAEGAFesfddvsfnkptaAEAAALVLKrdftrLTPAEAELLALKREGRMRDFLDLCVQS 182
Cdd:TIGR02788  82 DTVSITIRKPSLVDFSLDDYEEKGFF-------------DTVRAQSGT-----LSDNDEQLLELLDAGDIKEFLRLAIAS 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557  183 HRNIIIAGKTGSGKTTFARSLIERVPNSERLVTIEDVHELFLeNHPNRVHMIYGYGKG---RVSAVEALRSCMRQSPDRI 259
Cdd:TIGR02788 144 RKNIIISGGTGSGKTTFLKSLVDEIPKDERIITIEDTREIFL-PHPNYVHLFYSKGGQglaKVTPKDLLQSCLRMRPDRI 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557  260 FLAELRGDEAWEYLGSLNTAHPGSITTTHANNAIQTFQRVGTLIKQSEVGRVLDLDMINRTLFSTIDVVLYF----SDRK 335
Cdd:TIGR02788 223 ILGELRGDEAFDFIRAVNTGHPGSITTLHAGSPEEAFEQLALMVKSSQAGLGLDFAYIVKLVREVIDIVVQInrrgGGRK 302


                  ....*.
gi 730422557  336 LCEVFY 341
Cdd:TIGR02788 303 ITEVYF 308
 
Name Accession Description Interval E-value
VirB11 TIGR02788
P-type DNA transfer ATPase VirB11; The VirB11 protein is found in the vir locus of ...
 26-341 5.81e-120

P-type DNA transfer ATPase VirB11; The VirB11 protein is found in the vir locus of Agrobacterium Ti plasmids where it is involved in the type IV secretion system for DNA transfer. VirB11 is believed to be an ATPase. VirB11 is a homolog of the P-like conjugation system TrbB protein and the Flp pilus sytem protein TadA.


Pssm-ID: 274301  Cd Length: 308  Bit Score: 348.57  E-value: 5.81e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557   26 LERGDVVEVTINRPGELWAKTFQGWEPVKVPELTMPYLKSLANAIAVFNGISLAS---ITSVVLPGGQRGQIVLPPACID 102
Cdd:TIGR02788   2 LDDEDVTEICINRPGEVWVEGPGGWQRFDVPDLTFSHLMRLARAIASFSKQSISEenpILSATLPGGERVQIVIPPACEN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557  103 DTLSLSIRKHSLVVKTLDELDAEGAFesfddvsfnkptaAEAAALVLKrdftrLTPAEAELLALKREGRMRDFLDLCVQS 182
Cdd:TIGR02788  82 DTVSITIRKPSLVDFSLDDYEEKGFF-------------DTVRAQSGT-----LSDNDEQLLELLDAGDIKEFLRLAIAS 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557  183 HRNIIIAGKTGSGKTTFARSLIERVPNSERLVTIEDVHELFLeNHPNRVHMIYGYGKG---RVSAVEALRSCMRQSPDRI 259
Cdd:TIGR02788 144 RKNIIISGGTGSGKTTFLKSLVDEIPKDERIITIEDTREIFL-PHPNYVHLFYSKGGQglaKVTPKDLLQSCLRMRPDRI 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557  260 FLAELRGDEAWEYLGSLNTAHPGSITTTHANNAIQTFQRVGTLIKQSEVGRVLDLDMINRTLFSTIDVVLYF----SDRK 335
Cdd:TIGR02788 223 ILGELRGDEAFDFIRAVNTGHPGSITTLHAGSPEEAFEQLALMVKSSQAGLGLDFAYIVKLVREVIDIVVQInrrgGGRK 302


                  ....*.
gi 730422557  336 LCEVFY 341
Cdd:TIGR02788 303 ITEVYF 308
VirB11-like_ATPase cd01130
Type IV secretory pathway component VirB11-like; Type IV secretory pathway component VirB11, ...
 172-343 1.98e-66

Type IV secretory pathway component VirB11-like; Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir (virulence) proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the bacterial Ti (tumor-inducing)-plasmid into plant cells. The pilus is a fibrous cell surface organelle, which mediates adhesion between bacteria during conjugative transfer or between bacteria and host eukaryotic cells during infection. VirB11-related ATPases include Sulfolobus acidocaldarius FlaI, which plays key roles in archaellum (archaeal flagellum) assembly and motility functions, and the pilus assembly proteins CpaF/TadA and TrbB. This alignment contains the C-terminal domain, which is the ATPase.


Pssm-ID: 410874 [Multi-domain]  Cd Length: 177  Bit Score: 207.39  E-value: 1.98e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557 172 MRDFLDLCVQSHRNIIIAGKTGSGKTTFARSLIERVPNSERLVTIEDVHELFLeNHPNRVHMIY---GYGKGRVSAVEAL 248
Cdd:cd01130    1 MAAFLRLAVRARKNILISGGTGSGKTTLLNALLSFIPPDERIVTIEDTRELQL-PHPNVVHLLTrpgGGEKGEVTMADLL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557 249 RSCMRQSPDRIFLAELRGDEAWEYLGSLNTAHPGSITTTHANNAIQTFQRVGTLIKQSEVGrvLDLDMINRTLFSTIDVV 328
Cdd:cd01130   80 KAALRMRPDRIIVGEVRGGEAYDMLQAMNTGHPGSITTIHANSAEDAIDRLATLVLEAGVN--LDEEALRRLIASAIDVI 157

                        170       180
                 ....*....|....*....|
gi 730422557 329 LYFS-----DRKLCEVFYDP 343
Cdd:cd01130  158 VHVKrlgdgVRRVTEIYEVP 177
PRK13900 PRK13900
type IV secretion system ATPase VirB11; Provisional
 30-329 4.31e-63

type IV secretion system ATPase VirB11; Provisional


Pssm-ID: 184381  Cd Length: 332  Bit Score: 203.84  E-value: 4.31e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557  30 DVVEVTINRPGELWAKTFQGWEPVKVPELTMPYLKSLANAIAVFNGISLAS---ITSVVLPGGQRGQIVLPPACIDDTLS 106
Cdd:PRK13900  23 GVNEISINKPGEVWVEKKGDIRCEQIPELDLSHLKALGRLVAQATEQKISEekpLLSATLPNGYRIQIVFPPACEIGQIV 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557 107 LSIRKHSLVVKTLDELDAEGAFESfddvsfnkpTAAEaaalvlkrdfTRLTPAEAELLALKREGRMRDFLDLCVQSHRNI 186
Cdd:PRK13900 103 YSIRKPSGMQLTLDDYEKMGAFDE---------TATE----------SLVDEDDVILNELLAEKKIKEFLEHAVISKKNI 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557 187 IIAGKTGSGKTTFARSLIERVPNSERLVTIEDVHELFLENHPNRVHMIY---GYGKGRVSAVEALRSCMRQSPDRIFLAE 263
Cdd:PRK13900 164 IISGGTSTGKTTFTNAALREIPAIERLITVEDAREIVLSNHPNRVHLLAskgGQGRAKVTTQDLIEACLRLRPDRIIVGE 243

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 730422557 264 LRGDEAWEYLGSLNTAHPGSITTTHANNAIQTFQRVGTLIKQSEVGrvLDLDMINRTLFSTIDVVL 329
Cdd:PRK13900 244 LRGAEAFSFLRAINTGHPGSISTLHADSPAMAIEQLKLMVMQAGLG--MPPDQIKKYILNVVDIVV 307
CpaF COG4962
Pilus assembly protein, ATPase of CpaF family [Intracellular trafficking, secretion, and ...
 21-339 1.48e-59

Pilus assembly protein, ATPase of CpaF family [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 443988 [Multi-domain]  Cd Length: 386  Bit Score: 196.54  E-value: 1.48e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557  21 PIVPHLERGDVVEVTINRPGELWAKTFQGWEPVKVPELTMPYLKSLANAIAVFNG--ISLAS-ITSVVLPGGQRGQIVLP 97
Cdd:COG4962   58 PLEPLLDDPDVTDIMVNGPDEVFVERGGRLERTDVRFDSEEELRRLIERIAARVGrrLDESSpIVDARLPDGSRVNAVIP 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557  98 PACIDDTlSLSIRKHSLVVKTLDELDAEGAFesfddvsfnkptaaeaaalvlkrdftrlTPAeaellalkregrMRDFLD 177
Cdd:COG4962  138 PVARDGP-SLSIRKFRKRPLTLEDLVALGSL----------------------------TPE------------MAEFLR 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557 178 LCVQSHRNIIIAGKTGSGKTTFARSLIERVPNSERLVTIEDVHELFLeNHPNRVHMI----YGYGKGRVSAVEALRSCMR 253
Cdd:COG4962  177 AAVRARLNILVSGGTGSGKTTLLNALSGFIPPDERIVTIEDAAELQL-QHPHVVRLEtrppNVEGAGEVTLRDLVRNALR 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557 254 QSPDRIFLAELRGDEAWEYLGSLNTAHPGSITTTHANNAIQTFQRVGTLIKQSevGRVLDLDMINRTLFSTIDVVLY--- 330
Cdd:COG4962  256 MRPDRIIVGEVRGAEALDMLQAMNTGHDGSMSTLHANSARDALARLETLALMA--GENLPREAVRRQIASAIDLVVHler 333

                        330
                 ....*....|.
gi 730422557 331 FSD--RKLCEV 339
Cdd:COG4962  334 LRDgrRRVTEI 344
T2SSE pfam00437
Type II/IV secretion system protein; This family contains components of both the Type II ...
 28-298 3.03e-30

Type II/IV secretion system protein; This family contains components of both the Type II protein secretion system (T2SS), including Type 4 pilus (T4P), and Type IV protein secretion system (T4SS) from Gram-negative bacteria. VirB11 ATPase is a subunit of the Agrobacterium tumefaciens transfer DNA (T-DNA) transfer system, a type IV secretion pathway required for delivery of T-DNA and effector proteins to plant cells during infection. The cytoplasmic T2S E ATPase is a Zn-containing protein thought to provide the mechanical force for the secretion process. T2S-E contains Walker A and B motifs, that are essential for secretion and ATPase activity. ATPase PulE and XcpR from Klebsiella oxytoca and Pseudomonas aeruginosa respectively are required for protein secretion via the T2SS. ATPase PilB is required for T4P extension.


Pssm-ID: 425681 [Multi-domain]  Cd Length: 269  Bit Score: 116.23  E-value: 3.03e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557   28 RGDVVEVTINRPGE-LWAKTFQGWEPVKVPELTMPYLKSLANAIAVFNGISL--------ASITSVVLPGGQRGQIVLPP 98
Cdd:pfam00437   9 DEGASDIHVEPPERiVWIRFRVDGVLREIPFPDADALARLISRIKVMARLDIserrppqdGRLPLRIGGKGVRVRVSTLP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557   99 ACIDDTLSLSIRKHSLVVKTLDELdaeGAFESFDDvsfnkptaaeaaalvlkrdftrltpaeaellalkregrmrDFLDL 178
Cdd:pfam00437  89 TAGGEKLVIRLLDPSNVALSLDEL---GMTGAQDE----------------------------------------ALLEF 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557  179 CVQSHRNIIIAGKTGSGKTTFARSLIERVPNS-ERLVTIEDVHELFLEnHPNRVHMIygyGKGRVSAVEALRSCMRQSPD 257
Cdd:pfam00437 126 LRQPRGNILVTGPTGSGKTTTLYAALGELNTRdENIVTVEDPVEIQLE-GINQVQLN---ARAGVTFADLLRAILRQDPD 201

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 730422557  258 RIFLAELRGDEAWE-YLGSLNTAHPGsITTTHANNAIQTFQR 298
Cdd:pfam00437 202 RIMVGEIRDLETAEiALQAANTGHLV-LSTLHTNSAAGALTR 242
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 182-331 1.08e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 41.98  E-value: 1.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557   182 SHRNIIIAGKTGSGKTTFARSLIERVPNSER---LVTIEDVHELFLENHPNRVHMIYGYGKGRVSAVEALRSCMRQSPDR 258
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPGGgviYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPD 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 730422557   259 IFLAelrgDEAWEYLGSLNTAHPGSITTTHANNAIQTFQRVgTLIKQSEVGRVLDLDMINRTLFSTIDVVLYF 331
Cdd:smart00382  81 VLIL----DEITSLLDAEQEALLLLLEELRLLLLLKSEKNL-TVILTTNDEKDLGPALLRRRFDRRIVLLLIL 148
 
Name Accession Description Interval E-value
VirB11 TIGR02788
P-type DNA transfer ATPase VirB11; The VirB11 protein is found in the vir locus of ...
 26-341 5.81e-120

P-type DNA transfer ATPase VirB11; The VirB11 protein is found in the vir locus of Agrobacterium Ti plasmids where it is involved in the type IV secretion system for DNA transfer. VirB11 is believed to be an ATPase. VirB11 is a homolog of the P-like conjugation system TrbB protein and the Flp pilus sytem protein TadA.


Pssm-ID: 274301  Cd Length: 308  Bit Score: 348.57  E-value: 5.81e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557   26 LERGDVVEVTINRPGELWAKTFQGWEPVKVPELTMPYLKSLANAIAVFNGISLAS---ITSVVLPGGQRGQIVLPPACID 102
Cdd:TIGR02788   2 LDDEDVTEICINRPGEVWVEGPGGWQRFDVPDLTFSHLMRLARAIASFSKQSISEenpILSATLPGGERVQIVIPPACEN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557  103 DTLSLSIRKHSLVVKTLDELDAEGAFesfddvsfnkptaAEAAALVLKrdftrLTPAEAELLALKREGRMRDFLDLCVQS 182
Cdd:TIGR02788  82 DTVSITIRKPSLVDFSLDDYEEKGFF-------------DTVRAQSGT-----LSDNDEQLLELLDAGDIKEFLRLAIAS 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557  183 HRNIIIAGKTGSGKTTFARSLIERVPNSERLVTIEDVHELFLeNHPNRVHMIYGYGKG---RVSAVEALRSCMRQSPDRI 259
Cdd:TIGR02788 144 RKNIIISGGTGSGKTTFLKSLVDEIPKDERIITIEDTREIFL-PHPNYVHLFYSKGGQglaKVTPKDLLQSCLRMRPDRI 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557  260 FLAELRGDEAWEYLGSLNTAHPGSITTTHANNAIQTFQRVGTLIKQSEVGRVLDLDMINRTLFSTIDVVLYF----SDRK 335
Cdd:TIGR02788 223 ILGELRGDEAFDFIRAVNTGHPGSITTLHAGSPEEAFEQLALMVKSSQAGLGLDFAYIVKLVREVIDIVVQInrrgGGRK 302


                  ....*.
gi 730422557  336 LCEVFY 341
Cdd:TIGR02788 303 ITEVYF 308
VirB11-like_ATPase cd01130
Type IV secretory pathway component VirB11-like; Type IV secretory pathway component VirB11, ...
 172-343 1.98e-66

Type IV secretory pathway component VirB11-like; Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir (virulence) proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the bacterial Ti (tumor-inducing)-plasmid into plant cells. The pilus is a fibrous cell surface organelle, which mediates adhesion between bacteria during conjugative transfer or between bacteria and host eukaryotic cells during infection. VirB11-related ATPases include Sulfolobus acidocaldarius FlaI, which plays key roles in archaellum (archaeal flagellum) assembly and motility functions, and the pilus assembly proteins CpaF/TadA and TrbB. This alignment contains the C-terminal domain, which is the ATPase.


Pssm-ID: 410874 [Multi-domain]  Cd Length: 177  Bit Score: 207.39  E-value: 1.98e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557 172 MRDFLDLCVQSHRNIIIAGKTGSGKTTFARSLIERVPNSERLVTIEDVHELFLeNHPNRVHMIY---GYGKGRVSAVEAL 248
Cdd:cd01130    1 MAAFLRLAVRARKNILISGGTGSGKTTLLNALLSFIPPDERIVTIEDTRELQL-PHPNVVHLLTrpgGGEKGEVTMADLL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557 249 RSCMRQSPDRIFLAELRGDEAWEYLGSLNTAHPGSITTTHANNAIQTFQRVGTLIKQSEVGrvLDLDMINRTLFSTIDVV 328
Cdd:cd01130   80 KAALRMRPDRIIVGEVRGGEAYDMLQAMNTGHPGSITTIHANSAEDAIDRLATLVLEAGVN--LDEEALRRLIASAIDVI 157

                        170       180
                 ....*....|....*....|
gi 730422557 329 LYFS-----DRKLCEVFYDP 343
Cdd:cd01130  158 VHVKrlgdgVRRVTEIYEVP 177
PRK13900 PRK13900
type IV secretion system ATPase VirB11; Provisional
 30-329 4.31e-63

type IV secretion system ATPase VirB11; Provisional


Pssm-ID: 184381  Cd Length: 332  Bit Score: 203.84  E-value: 4.31e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557  30 DVVEVTINRPGELWAKTFQGWEPVKVPELTMPYLKSLANAIAVFNGISLAS---ITSVVLPGGQRGQIVLPPACIDDTLS 106
Cdd:PRK13900  23 GVNEISINKPGEVWVEKKGDIRCEQIPELDLSHLKALGRLVAQATEQKISEekpLLSATLPNGYRIQIVFPPACEIGQIV 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557 107 LSIRKHSLVVKTLDELDAEGAFESfddvsfnkpTAAEaaalvlkrdfTRLTPAEAELLALKREGRMRDFLDLCVQSHRNI 186
Cdd:PRK13900 103 YSIRKPSGMQLTLDDYEKMGAFDE---------TATE----------SLVDEDDVILNELLAEKKIKEFLEHAVISKKNI 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557 187 IIAGKTGSGKTTFARSLIERVPNSERLVTIEDVHELFLENHPNRVHMIY---GYGKGRVSAVEALRSCMRQSPDRIFLAE 263
Cdd:PRK13900 164 IISGGTSTGKTTFTNAALREIPAIERLITVEDAREIVLSNHPNRVHLLAskgGQGRAKVTTQDLIEACLRLRPDRIIVGE 243

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 730422557 264 LRGDEAWEYLGSLNTAHPGSITTTHANNAIQTFQRVGTLIKQSEVGrvLDLDMINRTLFSTIDVVL 329
Cdd:PRK13900 244 LRGAEAFSFLRAINTGHPGSISTLHADSPAMAIEQLKLMVMQAGLG--MPPDQIKKYILNVVDIVV 307
CpaF COG4962
Pilus assembly protein, ATPase of CpaF family [Intracellular trafficking, secretion, and ...
 21-339 1.48e-59

Pilus assembly protein, ATPase of CpaF family [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 443988 [Multi-domain]  Cd Length: 386  Bit Score: 196.54  E-value: 1.48e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557  21 PIVPHLERGDVVEVTINRPGELWAKTFQGWEPVKVPELTMPYLKSLANAIAVFNG--ISLAS-ITSVVLPGGQRGQIVLP 97
Cdd:COG4962   58 PLEPLLDDPDVTDIMVNGPDEVFVERGGRLERTDVRFDSEEELRRLIERIAARVGrrLDESSpIVDARLPDGSRVNAVIP 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557  98 PACIDDTlSLSIRKHSLVVKTLDELDAEGAFesfddvsfnkptaaeaaalvlkrdftrlTPAeaellalkregrMRDFLD 177
Cdd:COG4962  138 PVARDGP-SLSIRKFRKRPLTLEDLVALGSL----------------------------TPE------------MAEFLR 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557 178 LCVQSHRNIIIAGKTGSGKTTFARSLIERVPNSERLVTIEDVHELFLeNHPNRVHMI----YGYGKGRVSAVEALRSCMR 253
Cdd:COG4962  177 AAVRARLNILVSGGTGSGKTTLLNALSGFIPPDERIVTIEDAAELQL-QHPHVVRLEtrppNVEGAGEVTLRDLVRNALR 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557 254 QSPDRIFLAELRGDEAWEYLGSLNTAHPGSITTTHANNAIQTFQRVGTLIKQSevGRVLDLDMINRTLFSTIDVVLY--- 330
Cdd:COG4962  256 MRPDRIIVGEVRGAEALDMLQAMNTGHDGSMSTLHANSARDALARLETLALMA--GENLPREAVRRQIASAIDLVVHler 333

                        330
                 ....*....|.
gi 730422557 331 FSD--RKLCEV 339
Cdd:COG4962  334 LRDgrRRVTEI 344
PRK13851 PRK13851
type IV secretion system protein VirB11; Provisional
 18-331 1.22e-58

type IV secretion system protein VirB11; Provisional


Pssm-ID: 172375  Cd Length: 344  Bit Score: 192.81  E-value: 1.22e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557  18 LMRPIVPHLERGDVVEVTINRPGELWAKTFQGWEPVKVPeLTMPYLKS---LANAIAVFNGISLASITSVVLPGGQRGQI 94
Cdd:PRK13851  10 LLKPVLEWLDDPRTEEVAINRPGEAFVRQAGVFTKFPLP-LSYDDLEDiaiLAGALRKQDVGPRNPLCATELPGGERLQI 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557  95 VLPPACIDDTLSLSIRKHSLVVKTLDELDAEGAFESFDDVSFNKPTaaeaaalvlkRDFtrltpAEAELLALKREGRMRD 174
Cdd:PRK13851  89 CLPPTVPSGTVSLTIRRPSSRVSELKEVSSRYDASRWNQWQERRKR----------RDQ-----LDEAILRHYDNGDLEA 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557 175 FLDLCVQSHRNIIIAGKTGSGKTTFARSLIERVPNSERLVTIEDVHELFLEnHPNRVHMIY---GYGKGRVSAVEALRSC 251
Cdd:PRK13851 154 FLHACVVGRLTMLLCGPTGSGKTTMSKTLISAIPPQERLITIEDTLELVIP-HENHVRLLYsknGAGLGAVTAEHLLQAS 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557 252 MRQSPDRIFLAELRGDEAWEYLGSLNTAHPGSITTTHANNAIQTFQRVGTLIKQSEVGRVLDLDMINRTLFSTIDVVLYF 331
Cdd:PRK13851 233 LRMRPDRILLGEMRDDAAWAYLSEVVSGHPGSISTIHGANPVQGFKKLFSLVKSSAQGASLEDRTLIDMLATAIDVIVPF 312
heli_sec_ATPase TIGR03819
helicase/secretion neighborhood ATPase; Members of this protein family comprise a distinct ...
 21-292 4.02e-32

helicase/secretion neighborhood ATPase; Members of this protein family comprise a distinct clade of putative ATPase associated with an integral membrane complex likely to act in pilus formation, secretion, or conjugal transfer. The association of most members with a nearby gene for a DEAH-box helicase suggests a role in conjugal transfer.


Pssm-ID: 200328  Cd Length: 340  Bit Score: 122.83  E-value: 4.02e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557   21 PIVPHLERGDVVEVTINRPGELWAKTFQGWEPVKVPELTMPYLKSLANAIAVFNGISLASITSVV---LPGGQRGQIVLP 97
Cdd:TIGR03819  54 PLEPLLADPGVTDVLVNGPDEVWVDRGRGLERTDVRFPDEAAVRRLAQRLAAAAGRRLDDAQPWVdarLPDGTRLHAVLP 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557   98 PACIDDTLsLSIRKHSLVVKTLDELDAEGAFesfddvsfnkptAAEAAALvlkrdftrltpaeaellalkregrmrdfLD 177
Cdd:TIGR03819 134 PVATDGTC-LSLRVPRRRTFTLDELVAAGTI------------PPGVARL----------------------------LR 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557  178 LCVQSHRNIIIAGKTGSGKTTFARSLIERVPNSERLVTIEDVHELfLENHPNRVHMIY----GYGKGRVSAVEALRSCMR 253
Cdd:TIGR03819 173 ALVAARLAFLVSGGTGSGKTTLLSALLALVPPDERIVLVEDAAEL-RPDHPHVVRLEArpanVEGAGAVTLTDLVRQALR 251

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 730422557  254 QSPDRIFLAELRGDEAWEYLGSLNTAHPGSITTTHANNA 292
Cdd:TIGR03819 252 MRPDRIVVGEVRGAEVVDLLAALNTGHDGGAGTLHANSP 290
TrbB_P TIGR02782
P-type conjugative transfer ATPase TrbB; The TrbB protein is found in the trb locus of ...
 22-339 2.09e-30

P-type conjugative transfer ATPase TrbB; The TrbB protein is found in the trb locus of Agrobacterium Ti plasmids where it is involved in the type IV secretion system for plasmid conjugative transfer. TrbB is a homolog of the vir system VirB11 ATPase, and the Flp pilus sytem ATPase TadA. [Cellular processes, Conjugation]


Pssm-ID: 274297  Cd Length: 299  Bit Score: 117.54  E-value: 2.09e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557   22 IVPHLERGDVVEVTINRPGELWAKTF-QGWEPVKvpELTMPYLKSLANAIAVFNGISLAS---ITSVVLP-GGQRGQIVL 96
Cdd:TIGR02782  10 IAAALDDPGVVEIMLNPDGRLWVERLgSGMSPLG--EMSPADAQRIIGLVADYLGTEVDRdkpIVEGELPlDGSRFEGLI 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557   97 PPacIDDTLSLSIRKHSLVVKTLDELDAEGAFesfddvsfnkpTAAEAAALVlkrdftrltpaEAellalkregrmrdfl 176
Cdd:TIGR02782  88 PP--VVAAPSFAIRKKAVAVFTLDDYVEAGIM-----------TAAQRDVLR-----------EA--------------- 128

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557  177 dlcVQSHRNIIIAGKTGSGKTTFARSLIERVPNS---ERLVTIEDVHELFLENhPNrvHMIYGYGKGRVSAVEALRSCMR 253
Cdd:TIGR02782 129 ---VLARKNILVVGGTGSGKTTLANALLAEIAKNdptDRVVIIEDTRELQCAA-PN--VVQLRTSDDAISMTRLLKATLR 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557  254 QSPDRIFLAELRGDEAWEYLGSLNTAHPGSITTTHANNAIQTFQRVGTLIkqSEVGrvldlDMINRTLF-STIDVVLYF- 331
Cdd:TIGR02782 203 LRPDRIIVGEVRGGEALDLLKAWNTGHPGGIATIHANNAKAALDRLEQLI--QEVS-----VTPMQTLIaEAVDLVIFIa 275

                         330
                  ....*....|.
gi 730422557  332 ---SDRKLCEV 339
Cdd:TIGR02782 276 rtpAGRRVQEI 286
T2SSE pfam00437
Type II/IV secretion system protein; This family contains components of both the Type II ...
 28-298 3.03e-30

Type II/IV secretion system protein; This family contains components of both the Type II protein secretion system (T2SS), including Type 4 pilus (T4P), and Type IV protein secretion system (T4SS) from Gram-negative bacteria. VirB11 ATPase is a subunit of the Agrobacterium tumefaciens transfer DNA (T-DNA) transfer system, a type IV secretion pathway required for delivery of T-DNA and effector proteins to plant cells during infection. The cytoplasmic T2S E ATPase is a Zn-containing protein thought to provide the mechanical force for the secretion process. T2S-E contains Walker A and B motifs, that are essential for secretion and ATPase activity. ATPase PulE and XcpR from Klebsiella oxytoca and Pseudomonas aeruginosa respectively are required for protein secretion via the T2SS. ATPase PilB is required for T4P extension.


Pssm-ID: 425681 [Multi-domain]  Cd Length: 269  Bit Score: 116.23  E-value: 3.03e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557   28 RGDVVEVTINRPGE-LWAKTFQGWEPVKVPELTMPYLKSLANAIAVFNGISL--------ASITSVVLPGGQRGQIVLPP 98
Cdd:pfam00437   9 DEGASDIHVEPPERiVWIRFRVDGVLREIPFPDADALARLISRIKVMARLDIserrppqdGRLPLRIGGKGVRVRVSTLP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557   99 ACIDDTLSLSIRKHSLVVKTLDELdaeGAFESFDDvsfnkptaaeaaalvlkrdftrltpaeaellalkregrmrDFLDL 178
Cdd:pfam00437  89 TAGGEKLVIRLLDPSNVALSLDEL---GMTGAQDE----------------------------------------ALLEF 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557  179 CVQSHRNIIIAGKTGSGKTTFARSLIERVPNS-ERLVTIEDVHELFLEnHPNRVHMIygyGKGRVSAVEALRSCMRQSPD 257
Cdd:pfam00437 126 LRQPRGNILVTGPTGSGKTTTLYAALGELNTRdENIVTVEDPVEIQLE-GINQVQLN---ARAGVTFADLLRAILRQDPD 201

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 730422557  258 RIFLAELRGDEAWE-YLGSLNTAHPGsITTTHANNAIQTFQR 298
Cdd:pfam00437 202 RIMVGEIRDLETAEiALQAANTGHLV-LSTLHTNSAAGALTR 242
VirB11 COG0630
Type IV secretory pathway ATPase VirB11/Archaellum biosynthesis ATPase ArlI/FlaI [Cell ...
 76-329 2.95e-29

Type IV secretory pathway ATPase VirB11/Archaellum biosynthesis ATPase ArlI/FlaI [Cell motility, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440395 [Multi-domain]  Cd Length: 462  Bit Score: 117.10  E-value: 2.95e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557  76 ISLAS-ITSVVLPGGQRGQIVLPPaciDDTL---SLSIRKHSLVVKTLDELDAEGAFesfddvsfnkpTAAEAAalvlkr 151
Cdd:COG0630  222 ISVARpIVDATLPDGSRIALTLGP---EVSRrgsSFTIRKFREVPLTPIDLIEWGTL-----------SPELAA------ 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557 152 dftrltpaeaellalkregrmrdFLDLCVQSHRNIIIAGKTGSGKTTFARSLIERVPNSERLVTIEDVHELFLEnHPNRV 231
Cdd:COG0630  282 -----------------------YLWLLLENGKSVLVAGGTASGKTTLLNALLSFIPPDAKIVTIEDTRELNLP-HENWI 337

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557 232 HMI----YGYGKGRVSAVEALRSCMRQSPDRIFLAELRGDEAWEYLGSLNTAHPGsITTTHANNaiqtfqrVGTLIKqse 307
Cdd:COG0630  338 SLVtresFGGEEGDVTMFDLLKAALRQRPDYIVVGEVRGEEAYTLFQAMATGHGV-LSTFHADS-------VESAIN--- 406

                        250       260
                 ....*....|....*....|...
gi 730422557 308 vgRVLDLDM-INRTLFSTIDVVL 329
Cdd:COG0630  407 --RLTSPPInVPRTLLQALDLVV 427
type_II_IV_secretion_ATPases cd19477
type II/type IV hexameric secretion ATPases; RecA-like NTPases. This family includes the NTP ...
 184-341 8.67e-29

type II/type IV hexameric secretion ATPases; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410885 [Multi-domain]  Cd Length: 168  Bit Score: 109.41  E-value: 8.67e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557 184 RNIIIAGKTGSGKTTFARSLIERVPNSERLVTIEDVHELFLENHPNRVHMIYGygkGRVSAVEALRSCMRQSPDRIFLAE 263
Cdd:cd19477   11 KNVIVCGGTGSGKTTYIKSILEFIPKEERIISIEDTEEIVFKHHKNYTQLFFG---GNITSADCLKSCLRQRPDRIILGE 87

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 730422557 264 LRGDEAWEYLGSLNTAHPGSITTTHANNAIQTFQRVGTLIKQSEVGRVLDLDMINRTLFSTIDVVLYFSDRKLCEVFY 341
Cdd:cd19477   88 LRSSEAYDFYNVLCSGHKGTLTTLHAGSSEEAFIRLAN*SSSNSAARNIKFESLIEGFKDLIDGIVHINHHKQCDEFY 165
PRK13894 PRK13894
conjugal transfer ATPase TrbB; Provisional
 32-303 1.05e-22

conjugal transfer ATPase TrbB; Provisional


Pssm-ID: 184377  Cd Length: 319  Bit Score: 96.73  E-value: 1.05e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557  32 VEVTINRPGELWAKTFQgwEPVK-VPELTMPYLKSLANAIAVFNGISLASITSVV---LP-GGQR--GQivLPPACIDDT 104
Cdd:PRK13894  36 VEIMLNADGKLWQERLG--EPMRcIGTLRVAQAQAIIETIAGYHGKEVTRSKPILegeLPlDGSRfaGQ--LPPVVPAPT 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557 105 LSlsIRKHSLVVKTLDELDAEGAFesfddvsfnkpTAAEAAALVLkrdftrltpaeaellalkregrmrdfldlCVQSHR 184
Cdd:PRK13894 112 FA--IRKKAVAIFTLDQYVERGIM-----------TAAQREAIIA-----------------------------AVRAHR 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557 185 NIIIAGKTGSGKTTFARSLI-ERVPN--SERLVTIEDVHEL------FLENHPNRvhmiygygkgRVSAVEALRSCMRQS 255
Cdd:PRK13894 150 NILVIGGTGSGKTTLVNAIInEMVIQdpTERVFIIEDTGEIqcaaenYVQYHTSI----------DVNMTALLKTTLRMR 219

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 730422557 256 PDRIFLAELRGDEAWEYLGSLNTAHPGSITTTHANNAIQTFQRVGTLI 303
Cdd:PRK13894 220 PDRILVGEVRGPEALDLLMAWNTGHEGGAATLHANNAKAGLDRLKSLI 267
PRK13833 PRK13833
conjugal transfer protein TrbB; Provisional
 139-320 3.62e-17

conjugal transfer protein TrbB; Provisional


Pssm-ID: 172360 [Multi-domain]  Cd Length: 323  Bit Score: 81.00  E-value: 3.62e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557 139 PTAAEAAALVLKRDFTRLTPAEAELlalkREGRMRD----FLDLCVQSHRNIIIAGKTGSGKTTFARSLIERVPNS---E 211
Cdd:PRK13833 100 PPVVSGPAFTIRRRASRLIPLDDYV----TSKIMTEaqasVIRSAIDSRLNIVISGGTGSGKTTLANAVIAEIVASapeD 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557 212 RLVTIEDVHELFLENHpNRVHMiygYGKGRVSAVEALRSCMRQSPDRIFLAELRGDEAWEYLGSLNTAHPGSITTTHANN 291
Cdd:PRK13833 176 RLVILEDTAEIQCAAE-NAVAL---HTSDTVDMARLLKSTMRLRPDRIIVGEVRDGAALTLLKAWNTGHPGGVTTIHSNT 251

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 730422557 292 AIQTFQRVGTLIK-------QSEVGRVLDLDM-INRT 320
Cdd:PRK13833 252 AMSALRRLEQLTAeasqqpmQEVIGEAVDLIVsIERT 288
PilT cd01131
Pilus retraction ATPase PilT; Pilus retraction ATPase PilT is a nucleotide-binding protein ...
 186-299 2.72e-11

Pilus retraction ATPase PilT; Pilus retraction ATPase PilT is a nucleotide-binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism known as twitching motility.


Pssm-ID: 410875 [Multi-domain]  Cd Length: 223  Bit Score: 62.55  E-value: 2.72e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557 186 IIIAGKTGSGKTTFARSLIERVpNSER---LVTIEDVHElFLenHPNRVHMIYGYGKGR--VSAVEALRSCMRQSPDRIF 260
Cdd:cd01131   24 VLVTGPTGSGKSTTLAAMIDYI-NETRskhIITIEDPIE-FV--HKHKKSLINQREVGRdtESFAAALRAALREDPDVIL 99

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 730422557 261 LAELRGDEAWEYlgSLNTAHPGS--ITTTHANNAIQTFQRV 299
Cdd:cd01131  100 VGEMRDLETIEL--ALTAAETGHlvFSTLHTNSAAQTIDRI 138
DotB_TraJ cd19516
dot/icm secretion system protein DotB-like; Defect in organelle trafficking (Dot)B is part of ...
 186-326 9.11e-11

dot/icm secretion system protein DotB-like; Defect in organelle trafficking (Dot)B is part of the type IVb secretion (T4bS) system, also known as the dot/icm system, and is the main energy supplier of the secretion system. It is an ATPase, similar to the VirB11 component of the T4aS systems. This family also includes Escherichia coli IncI plasmid-encoded conjugative transfer ATPase TraJ encoded on the tra (transfer) operon.


Pssm-ID: 410924 [Multi-domain]  Cd Length: 179  Bit Score: 60.08  E-value: 9.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557 186 IIIAGKTGSGKTTFA----RSLIERVPNSERLVTIEDVHELFLENHPNRVHMIYGYGKGR--VSAVEALRSCMRQSPDRI 259
Cdd:cd19516   14 VYVAGATGSGKSTLLaaiyRYILENDPPDRKIITYEDPIEFVYDGIKSKHSIIVQSQIPRhfKSFAKAVREALRRKPSLI 93

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 730422557 260 FLAELRGDEAWE-YLGSLNTAHPgSITTTHANN-------AIQTF---QRVGTLIKQSEVGRVldldMINRTLFSTID 326
Cdd:cd19516   94 GVGELRDQETISaAVEASLTGHP-VYSTVHTKSvaetirrLISLFppeERDAAAYDLLSTLRF----IIVQRLVRTTD 166
PulE-GspE-like cd01129
PulE-GspE family; PulE and General secretory pathway protein GspE are ATPases of the type II ...
 174-298 2.05e-10

PulE-GspE family; PulE and General secretory pathway protein GspE are ATPases of the type II secretory pathway, the main terminal branch of the general secretory pathway (GSP). PulE is a cytoplasmic protein of the GSP, which contains an ATP binding site and a tetracysteine motif. This subgroup also includes PilB, a type IV pilus assembly ATPase, DotB, an ATPase of the type IVb secretion system, also known as the dot/icm system, Escherichia coli IncI plasmid-encoded conjugative transfer ATPase TraJ, and HofB.


Pssm-ID: 410873 [Multi-domain]  Cd Length: 159  Bit Score: 58.65  E-value: 2.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557 174 DFLDLCVQSHRNIIIAGKTGSGKTTFARSLIERVPNSER-LVTIEDVHELfleNHPNRVHMIYGYGKGRVSAvEALRSCM 252
Cdd:cd01129    2 RLRRLIKRPHGLILVTGPTGSGKTTTLYAMLRELNGPERnIITIEDPVEY---QIPGINQSQVNEKIGLTFA-DALRAIL 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 730422557 253 RQSPDRIFLAELR-GDEAWEYLGSLNTAHPgSITTTHANNAIQTFQR 298
Cdd:cd01129   78 RQDPDIIMVGEIRdAETAEIAIRAALTGHL-VLSTLHTNDALGAITR 123
PilT COG2805
Type IV pilus assembly protein PilT, pilus retraction ATPase [Cell motility, Extracellular ...
 186-299 1.87e-08

Type IV pilus assembly protein PilT, pilus retraction ATPase [Cell motility, Extracellular structures];


Pssm-ID: 442056  Cd Length: 342  Bit Score: 55.10  E-value: 1.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557 186 IIIAGKTGSGKTTFARSLIERVpNSER---LVTIEDVHElFLenHPNRvhmiygygKGRVSAVE----------ALRSCM 252
Cdd:COG2805  128 VLVTGPTGSGKSTTLAAMIDYI-NETRakhIITIEDPIE-FV--HKHK--------KSLINQREvgrdtpsfanALRAAL 195

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 730422557 253 RQSPDRIFLAELRGDEaweylgSLNTA-------HPgSITTTHANNAIQTFQRV 299
Cdd:COG2805  196 REDPDVILVGEMRDLE------TIEAAltaaetgHL-VFATLHTNSAAQTIDRI 242
PRK06696 PRK06696
uridine kinase; Validated
 161-244 8.62e-05

uridine kinase; Validated


Pssm-ID: 180660  Cd Length: 223  Bit Score: 43.04  E-value: 8.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557 161 AELLALKREGRMRdfldlcvqshrnIIIAGKTGSGKTTFARSLIERVPNSERLVT---IEDVHelflenHPNRVHmiygY 237
Cdd:PRK06696  12 EHILTLNLTRPLR------------VAIDGITASGKTTFADELAEEIKKRGRPVIrasIDDFH------NPRVIR----Y 69


                 ....*..
gi 730422557 238 GKGRVSA 244
Cdd:PRK06696  70 RRGRESA 76
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 182-331 1.08e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 41.98  E-value: 1.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557   182 SHRNIIIAGKTGSGKTTFARSLIERVPNSER---LVTIEDVHELFLENHPNRVHMIYGYGKGRVSAVEALRSCMRQSPDR 258
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPGGgviYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPD 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 730422557   259 IFLAelrgDEAWEYLGSLNTAHPGSITTTHANNAIQTFQRVgTLIKQSEVGRVLDLDMINRTLFSTIDVVLYF 331
Cdd:smart00382  81 VLIL----DEITSLLDAEQEALLLLLEELRLLLLLKSEKNL-TVILTTNDEKDLGPALLRRRFDRRIVLLLIL 148
PRK10436 PRK10436
hypothetical protein; Provisional
 186-302 5.54e-04

hypothetical protein; Provisional


Pssm-ID: 236694  Cd Length: 462  Bit Score: 41.45  E-value: 5.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730422557 186 IIIAGKTGSGKT-TFARSLIERVPNSERLVTIEDVHELFLE--NHpNRVHMIYGYGKGRVsaveaLRSCMRQSPDRIFLA 262
Cdd:PRK10436 221 ILVTGPTGSGKTvTLYSALQTLNTAQINICSVEDPVEIPLAgiNQ-TQIHPKAGLTFQRV-----LRALLRQDPDVIMVG 294

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 730422557 263 ELRGDEAWEYlgSLNTAHPGSI--TTTHANNAIQTFQRVGTL 302
Cdd:PRK10436 295 EIRDGETAEI--AIKAAQTGHLvlSTLHTNSTSETLVRLQQM 334
AAA_7 pfam12775
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 ...
 171-216 1.76e-03

P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the third nucleotide binding sites in the dynein motor. However, AAA3 has lost the catalytic residues necessary for ATP hydrolysis (the Walker B glutamate, the arginine finger, sensor-I and sensor-II motifs).


Pssm-ID: 463698 [Multi-domain]  Cd Length: 179  Bit Score: 38.91  E-value: 1.76e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 730422557  171 RMRDFLDLCVQSHRNIIIAGKTGSGKTTFARSLIERVPNSERLVTI 216
Cdd:pfam12775  19 RYTYLLDLLLKNGKPVLLVGPTGTGKTVIIQNLLRKLDKEKYLPLF 64
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 186-217 2.68e-03

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 38.67  E-value: 2.68e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 730422557 186 IIIAGKTGSGKTTFARSLIERVPNsERLVTIE 217
Cdd:COG0572   10 IGIAGPSGSGKTTFARRLAEQLGA-DKVVVIS 40
PRK05480 PRK05480
uridine/cytidine kinase; Provisional
 181-229 4.22e-03

uridine/cytidine kinase; Provisional


Pssm-ID: 235492 [Multi-domain]  Cd Length: 209  Bit Score: 37.83  E-value: 4.22e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 730422557 181 QSHRNIII--AGKTGSGKTTFARSLIERVPNsERLVTIE------DVHELFLEN-------HPN 229
Cdd:PRK05480   2 MMKKPIIIgiAGGSGSGKTTVASTIYEELGD-ESIAVIPqdsyykDQSHLSFEErvktnydHPD 64
HerA COG0433
Archaeal DNA helicase HerA or a related bacterial ATPase, contains HAS-barrel and ATPase ...
 184-206 4.45e-03

Archaeal DNA helicase HerA or a related bacterial ATPase, contains HAS-barrel and ATPase domains [Replication, recombination and repair];


Pssm-ID: 440202 [Multi-domain]  Cd Length: 388  Bit Score: 38.82  E-value: 4.45e-03
                         10        20
                 ....*....|....*....|...
gi 730422557 184 RNIIIAGKTGSGKTTFARSLIER 206
Cdd:COG0433   48 RHILILGATGSGKSNTLQVLLEE 70
PRK06547 PRK06547
hypothetical protein; Provisional
 159-220 5.77e-03

hypothetical protein; Provisional


Pssm-ID: 235825  Cd Length: 172  Bit Score: 37.03  E-value: 5.77e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 730422557 159 AEAELLALKREGRMRdfldlcvqshrNIIIAGKTGSGKTTFARSLIERVpnSERLVTIEDVH 220
Cdd:PRK06547   2 LVALIAARLCGGGMI-----------TVLIDGRSGSGKTTLAGALAART--GFQLVHLDDLY 50
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
186-208 5.93e-03

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 37.20  E-value: 5.93e-03
                         10        20
                 ....*....|....*....|...
gi 730422557 186 IIIAGKTGSGKTTFARSLIERVP 208
Cdd:COG0645    2 ILVCGLPGSGKSTLARALAERLG 24
UMPK cd02023
Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or ...
 186-217 7.96e-03

Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, this enzyme combined with nucleoside diphosphate kinases further phosphorylates UMP and CMP to form UTP and CTP. This kinase also catalyzes the phosphorylation of several cytotoxic ribonucleoside analogs such as 5-flurrouridine and cyclopentenyl-cytidine.


Pssm-ID: 238981 [Multi-domain]  Cd Length: 198  Bit Score: 37.15  E-value: 7.96e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 730422557 186 IIIAGKTGSGKTTFARSLIERVPNsERLVTIE 217
Cdd:cd02023    2 IGIAGGSGSGKTTVAEEIIEQLGN-PKVVIIS 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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